Identification

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Name
Homosalate
Accession Number
DB11064
Type
Small Molecule
Groups
Approved, Investigational
Description

Homosalate is an organic compound that belongs to salicylates. It is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol. Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light. Homosalate specifically absorbs short-wave UVB rays, which are associated with DNA damage and increased risk of skin cancer.

It is a common ingredient in many commercially available sunscreens. There are no reported adverse effects from homosalate.

Synonyms
  • Homosalate
Active Moieties
NameKindUNIICASInChI Key
Salicylic acidunknownO414PZ4LPZ69-72-7YGSDEFSMJLZEOE-UHFFFAOYSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sei Bella Age Defying Foundation AlmondLiquid2.9313 g/30mLTopicalMelaleuca, Inc.2011-05-022013-02-01Us
Sei Bella Age Defying Foundation BeigeLiquid2.9313 g/30mLTopicalMelaleuca, Inc.2011-05-022013-02-01Us
Sei Bella Age Defying Foundation CashmereLiquid2.9313 g/30mLTopicalMelaleuca, Inc.2011-05-022013-02-01Us
Sei Bella Age Defying Foundation ChestnutLiquid2.9313 g/30mLTopicalMelaleuca, Inc.2011-05-022013-02-01Us
Sei Bella Age Defying Foundation Classic BeigeLiquid2.9313 g/30mLTopicalMelaleuca, Inc.2011-05-022013-02-01Us
Sei Bella Age Defying Foundation EspressoLiquid2.9313 g/30mLTopicalMelaleuca, Inc.2011-05-022013-02-01Us
Sei Bella Age Defying Foundation FawnLiquid2.9313 g/30mLTopicalMelaleuca, Inc.2011-05-022013-02-01Us
Sei Bella Age Defying Foundation GoldenLiquid2.9313 g/30mLTopicalMelaleuca, Inc.2011-05-022013-02-01Us
Sei Bella Age Defying Foundation IvoryLiquid2.9313 g/30mLTopicalMelaleuca, Inc.2011-05-022013-02-01Us
Sei Bella Age Defying Foundation NaturalLiquid2.9313 g/30mLTopicalMelaleuca, Inc.2011-05-022013-02-01Us
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
100 SPF CreamHomosalate (15 %) + Avobenzone (3 %) + Octisalate (5 %) + Octocrylene (10 %) + Oxybenzone (6 %)CreamTopicalVital Science A Div. Of/Une Div. De Valeant Canada Ltd/Ltee2010-06-032014-08-27Canada
14-day Skin Rescue SPF 30Homosalate (4 %) + Avobenzone (3 %) + Octisalate (5 %) + Octocrylene (2.35 %) + Oxybenzone (6 %)CreamTopicalJohnson & Johnson2009-02-162013-07-31Canada
15 Tanning CVSHomosalate (10 g/100mL) + Avobenzone (2 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (5 g/100mL)LotionTopicalProduct Quest Mff, Llc2014-11-062016-04-20Us
2 in 1 Sunscreen and Gradual Self-TannerHomosalate (15 g/100mL) + Avobenzone (3 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (8 g/100mL)Aerosol, sprayTopicalSunless, Inc2018-09-07Not applicableUs
21STAY A Thera Sun BlockHomosalate (20 mg/1mL) + Octinoxate (60 mg/1mL) + Octisalate (40 mg/1mL) + Titanium dioxide (54.6 mg/1mL) + Zinc oxide (58.2 mg/1mL)CreamTopicalOracle Cosmetic Co., Ltd.2017-11-21Not applicableUs
24K Bio-Brightening Skin Tone Moisturizer SPF 30Homosalate (6.2 g/100g) + Avobenzone (1.5 g/100g) + Octinoxate (7.4 g/100g) + Octisalate (5 g/100g) + Oxybenzone (3.1 g/100g)CreamTopicalVivo Per-lei, Inc.2014-10-032019-12-31Us
24K Skin Tone Moisturizer SPF 30Homosalate (6.2 g/100g) + Avobenzone (1.5 g/100g) + Octinoxate (7.4 g/100g) + Octisalate (5.0 g/100g) + Oxybenzone (3.1 g/100g)CreamTopicalVivo Per-lei, Inc.2019-07-29Not applicableUs
29 by LYDIA MONDAVI Napa Valley BROAD SPECTRUM SPF 30 D VINE DAYHomosalate (100 mg/1mL) + Avobenzone (30 mg/1mL) + Octisalate (50 mg/1mL) + Octocrylene (20 mg/1mL) + Oxybenzone (25 mg/1mL)CreamTopical29 Luxury Goods, Inc.2013-10-16Not applicableUs
2X Sunblock SPF 50Homosalate (15 mL/100mL) + Avobenzone (3 mL/100mL) + Octocrylene (6 mL/100mL) + Oxybenzone (6 mL/100mL)LiquidTopicalNupur Formulations Inc2011-04-22Not applicableUs
3-in-1 Face Moisturizer Broad Spectrum SPF 20Homosalate (10 g/100mL) + Avobenzone (3 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (10 g/100mL)JellyTopicalJafra cosmetics International2019-03-27Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
BEYOND THE SHAVE For MenHomosalate (2.5 g/100mL) + Allantoin (0.5 g/100mL) + Avobenzone (3.0 g/100mL) + Dimethicone (2.9 g/100mL) + Octasulfur (3.0 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (2.7 g/100mL)KitTopicalRodan & Fields2017-06-01Not applicableUs
REVERS Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Travel SizeHomosalate (10 g/100mL) + Avobenzone (3.0 g/100mL) + Hydroquinone (2 g/100mL) + Hydroquinone (2 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (2.6 g/100mL)KitTopicalRodan & Fields2017-07-24Not applicableUs
REVERSE Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age SpotsHomosalate (10 g/100mL) + Avobenzone (3.0 g/100mL) + Hydroquinone (2 g/100mL) + Hydroquinone (2 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (2.6 g/100mL)KitTopicalRodan & Fields2017-06-01Not applicableUs
Skinprint Ultra Sheer SPF 20Homosalate (15 g/100g) + Avobenzone (3 g/100g) + Ensulizole (4 g/100g) + Octisalate (5 g/100g) + Octocrylene (2.7 g/100g) + Oxybenzone (5 g/100g)LotionTopicalThe Skin Atelier, Inc.2010-10-06Not applicableUs
Categories
UNII
V06SV4M95S
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

As ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer.

Associated Conditions
Pharmacodynamics

Acts as UV filters.

Mechanism of action

Homosalate has the ability to convert incident ultraviolet radiation into less damaging infrared radiation (heat).

TargetActionsOrganism
UProgesterone receptor
antagonist
Humans
UAndrogen receptor
antagonist
Humans
UEstrogen receptor alphaNot AvailableHumans
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

For local use only, no systemic absorption.

Volume of distribution

For local use only, no systemic absorption.

Protein binding

For local use only, no systemic absorption.

Metabolism

For local use only, no systemic absorption.

Route of elimination

For local use only, no systemic absorption.

Half life

For local use only, no systemic absorption.

Clearance

For local use only, no systemic absorption.

Toxicity

LD50: Not available.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
  1. MSDS [Link]
  2. product info [Link]
External Links
PubChem Substance
347911103
Wikipedia
Homosalate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingOtherSystemic Exposure to Sunscreen Ingredients1
4TerminatedNot AvailableSkin Aging1
Not AvailableCompletedDiagnosticDermatitis, Photocontact1
Not AvailableCompletedPreventionSunscreening Agents1
Not AvailableCompletedTreatmentFoot Dryness in Patients With NIDDM / Foot Transepidermal Water Loss in Patients in NIDDM1
Not AvailableTerminatedTreatmentDiaper Rash1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Lotion; sprayTopical
OilTopical
Cream, augmentedTopical
KitTopical
StickTopical
JellyTopical
GelTopical
SalveTopical
Aerosol, foamTopical
AerosolTopical
LotionTopical
CreamTopical
LiquidTopical
Kit; stickTopical
PasteTopical
Kit
OintmentTopical
Lotion / shampooTopical
SolutionTopical
PowderTopical
SuspensionTopical
Kit; lotionTopical
Cream; kitTopical
LiquidTopical2.9313 g/30mL
SprayOral
EmulsionTopical
SprayTopical
LotionOral
ClothTopical
LipstickTopical
Aerosol, sprayTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Antagonist
General Function
Zinc ion binding
Specific Function
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor ...
Gene Name
PGR
Uniprot ID
P06401
Uniprot Name
Progesterone receptor
Molecular Weight
98979.96 Da
References
  1. Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B: Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005 Feb;83(2):264-72. Epub 2004 Nov 10. [PubMed:15537743]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Antagonist
General Function
Zinc ion binding
Specific Function
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription ...
Gene Name
AR
Uniprot ID
P10275
Uniprot Name
Androgen receptor
Molecular Weight
98987.9 Da
References
  1. Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B: Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005 Feb;83(2):264-72. Epub 2004 Nov 10. [PubMed:15537743]
  2. Jimenez-Diaz I, Molina-Molina JM, Zafra-Gomez A, Ballesteros O, Navalon A, Real M, Saenz JM, Fernandez MF, Olea N: Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Oct 1;936:80-7. doi: 10.1016/j.jchromb.2013.08.006. Epub 2013 Aug 8. [PubMed:24004914]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissu...
Gene Name
ESR1
Uniprot ID
P03372
Uniprot Name
Estrogen receptor
Molecular Weight
66215.45 Da
References
  1. Jimenez-Diaz I, Molina-Molina JM, Zafra-Gomez A, Ballesteros O, Navalon A, Real M, Saenz JM, Fernandez MF, Olea N: Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Oct 1;936:80-7. doi: 10.1016/j.jchromb.2013.08.006. Epub 2013 Aug 8. [PubMed:24004914]

Drug created on December 03, 2015 09:51 / Updated on September 02, 2019 19:19