Anti-Infective Agents, Local

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.
DrugDrug NameDrug Description
DB11073CetylpyridiniumA compound used to reduce plaque and gingivitis, as well as whiten teeth.
DB11105BenzalkoniumAn antiseptic agent used as a preservative in medications or as a disinfectant in cleaning products.
DB00756HexachloropheneA chlorinated bisphenol antiseptic used as a surgical scrub and skin cleanser.
DB11125BenzethoniumA medication used as to clean hands and clean minor cuts and scrapes.
DB12624OctenidineOctenidine is under investigation in clinical trial NCT02697162 (Antiseptic-coated Intermittent Urinary Catheter).
DB00027Gramicidin DA bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections.
DB00257ClotrimazoleA topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.
DB00406Gentian violet cationAn antiseptic violet dye used to prevent various infections, including fungal and bacterial infections.
DB00614FurazolidoneFor the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.
DB00626BacitracinA cyclic polypeptide antibiotic used to prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections.
DB00634SulfacetamideA corticosteroid used to treat inflammatory ocular conditions and acne vulgaris.
DB00826NatamycinA macrolide antifungal used to treat fungal infections of the eye.
DB00878ChlorhexidineAn antiseptic used to clean hands in surgery and healthcare practice, and to reduce pocket depth in periodontitis.
DB00898EthanolFor therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical...
DB01123ProflavineA topical antiseptic agent used in wound dressings to prevent infections.
DB01718CetrimoniumA compound that can be used as a topical antiseptic.
DB01744CamphorA compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.
DB02513ThymolAn essential oil found in various over-the-counter antibacterial and antifungal products.
DB03255PhenolAn antiseptic and disinfectant used in a variety of settings.
DB03843FormaldehydeA naturally occurring hazardous organic compound used as a preservative in animal feed, cosmetic products, laboratory procedures, disinfection, and home building products.
DB03895Malachite GreenNot Available
DB04209DequaliniumA quaternary ammonium cation antimicrobial agent used to treat common infections of the mouth and throat that has been studied in the treatment of vaginal candidiasis.
DB04813BithionolBithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the...
DB05245Silver sulfadiazineA topical sulfonamide antibiotic that acts on the bacterial cell wall and cell membrane; approved for the treatment of burns.
DB06795MafenideAn antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.
DB06812Povidone-iodineA topical antiseptic agent used for the treatment and prevention of infection in wounds.
DB08604TriclosanAn antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew.
DB08958HexetidineAn topical antiseptic agent used for disinfection and prevention of bacterial, fungal and yeast infections of the oral and vaginal mucosa.
DB11080Silver nitrateSilver nitrate is an inorganic compound with the chemical formula AgNO3. In its solid form, silver nitrate is coordinated in a trigonal planar arrangement. It is often used as a...
DB11091Hydrogen peroxideA compound used as a disinfectant and sterilizer.
DB11121ChloroxylenolAn antimicrobial used to treat cuts, bites, stings, abrasions, and used as an antiseptic hand cleaner.
DB11155TriclocarbanAn antibacterial agent used in liquid soaps and body washes.
DB11218Tea tree oilIndicated for topical use to help protect against infection in minor cuts, scrapes, and burns. No FDA-approved therapeutic indications.
DB11279Brilliant green cationAn ingredient used in topical medications to prevent infections of the umbilical cord.
DB11304PhenoxyethanolAn antiseptic used as a hand disinfectant or preservative in medications.
DB11561AminacrineA highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH...
DB11583CetalkoniumAn antiseptic used as a preservative or to treat certain topical infections.
DB12473TaurolidineTaurolidine has been investigated for the prevention of Central Venous Catheter, Home Parenteral Nutrition, and Catheter-Related Infections.
DB13154ParachlorophenolAn antibacterial agent used to prevent infections in root canals.
DB13282BenzododeciniumBenzododecinium is used as an antiseptic/disinfectant compound. It has been marketed as a tincture for antiseptic product for wounds in the Czech Republic.
DB13503TyrothricinA topical antibiotic with broad spectrum activity against Gram positive bacteria and some fungal infections.
DB13548DibrompropamidineNot Annotated
DB13705DecamethoxineNot Annotated
DB13765Mercuric chlorideMercury chloride (HgCl2) is a highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a...
DB13838NoxytiolinLocal antibacterial that probably acts by releasing formaldehyde in aqueous solutions. It is used for THERAPEUTIC IRRIGATION of infected body cavities - bladder, peritoneum, etc. and as a spray for...
DB13960BronopolAn antimicrobial compound used as a biocide and preservative.
DB14015Sodium bisulfiteSodium bisulfite has been used externally for parasitic skin diseases and as gastrointestinal antiseptic.
DB11254HexylresorcinolAn ingredient used to relieve irritation, pain, and prevent infection.
DB13269Dichlorobenzyl alcoholA medication used to treat a sore throat.
DB13373Acriflavinium chlorideNot Annotated
DB13697AmbazoneNot Annotated
DB13774MyristalkoniumNot Annotated
DB11145OxyquinolineA medication used in combination with other medications to restore vaginal pH.
DB13306ChlorquinaldolChlorquinaldol was used historically as a topical antiseptic agent for skin infections. It maintains use in European countries as a combination vaginal tablet with promestriene for use in the treatment...
DB05382IodineAn ingredient of nutritional supplements that is also used for disinfection.
DB14708TosylchloramideTosylchloramide, also known as chloramine-T, is a chlorinated and deprotonated sulfonamide used as a mild disinfectant. It is not stable in the water dissolved form.
DB02192Phenylethyl alcoholAn antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.
DB03808HexamidineNot Available
DB11129Carbamide peroxideA medication used to loosen ear wax, whiten teeth, and clean oral wounds.
DrugDrug NameTargetType
DB00756HexachloropheneD-lactate dehydrogenasetarget
DB00756HexachloropheneGlutamate dehydrogenase 1, mitochondrialtarget
DB00756HexachloropheneSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialtarget
DB00756HexachloropheneEstrogen receptor alphatarget
DB00027Gramicidin DP-glycoprotein 1transporter
DB00257ClotrimazoleIntermediate conductance calcium-activated potassium channel protein 4target
DB00257ClotrimazoleCytochrome P450 2D6enzyme
DB00257ClotrimazoleCytochrome P450 2C8enzyme
DB00257ClotrimazoleCytochrome P450 3A4enzyme
DB00257ClotrimazoleCytochrome P450 2B6enzyme
DB00257ClotrimazoleP-glycoprotein 1transporter
DB00257ClotrimazoleCytochrome P450 2A6enzyme
DB00257ClotrimazoleCytochrome P450 2C9enzyme
DB00257ClotrimazoleCytochrome P450 2E1enzyme
DB00257ClotrimazoleCytochrome P450 3A7enzyme
DB00257ClotrimazoleCytochrome P450 51target
DB00257ClotrimazoleNuclear receptor subfamily 1 group I member 2target
DB00257ClotrimazoleHydroxycarboxylic acid receptor 2target
DB00257ClotrimazoleBile salt export pumptransporter
DB00257ClotrimazoleSolute carrier organic anion transporter family member 1B1transporter
DB00257ClotrimazoleSolute carrier organic anion transporter family member 1B3transporter
DB00406Gentian violet cationDNAtarget
DB00406Gentian violet cationSolute carrier family 22 member 1transporter
DB00614FurazolidoneAmine oxidase [flavin-containing] Benzyme
DB00614FurazolidoneAmine oxidase [flavin-containing] Aenzyme
DB00626BacitracinInsulin-degrading enzymetarget
DB00626BacitracinC55-isoprenyl pyrophosphatetarget
DB00626BacitracinBacitracin transport ATP-binding protein BcrAtransporter
DB00626BacitracinBacitracin transport permease protein BCRBtransporter
DB00626BacitracinBacitracin transport permease protein BcrCtransporter
DB00634SulfacetamideDihydropteroate synthasetarget
DB00634SulfacetamideDihydropteroate synthase type-1target
DB00634SulfacetamideFolic acid synthesis protein FOL1target
DB00826NatamycinCytochrome P450 3A4enzyme
DB00878ChlorhexidineBacterial outer membranetarget
DB00878ChlorhexidineHistamine N-methyltransferasetarget
DB00878ChlorhexidineChloramphenicol acetyltransferasetarget
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-1target
DB00898EthanolGlutamate receptor ionotropic, NMDA 3Atarget
DB00898EthanolGlycine receptor subunit alpha-1target
DB00898EthanolGlycine receptor subunit alpha-2target
DB00898EthanolCytochrome P450 2E1enzyme
DB00898EthanolCytochrome P450 1A1enzyme
DB00898EthanolCytochrome P450 1A2enzyme
DB00898EthanolCytochrome P450 2B6enzyme
DB00898EthanolCytochrome P450 2C19enzyme
DB00898EthanolCytochrome P450 2C9enzyme
DB00898EthanolCytochrome P450 3A4enzyme
DB00898EthanolCytochrome P450 4A11enzyme
DB00898EthanolAlcohol dehydrogenase 1Aenzyme
DB00898EthanolAlcohol dehydrogenase 1Benzyme
DB00898EthanolAlcohol dehydrogenase 1Cenzyme
DB00898EthanolAlcohol dehydrogenase class-3enzyme
DB00898EthanolVoltage-dependent L-type calcium channel subunit beta-1target
DB00898Ethanol5-hydroxytryptamine receptor 3Atarget
DB00898EthanolAlcohol dehydrogenase 4enzyme
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-2target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-10target
DB00898EthanolVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-5target
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-4target
DB00898EthanolAlcohol dehydrogenase class 4 mu/sigma chainenzyme
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-3target
DB00898EthanolGlutamate receptor 1target
DB00898EthanolVoltage-dependent calcium channel gamma-1 subunittarget
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-2target
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-6target
DB00898EthanolGlutamate receptor 2target
DB00898EthanolGlutamate receptor 4target
DB00898EthanolGlutamate receptor 3target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-4target
DB00898EthanolNeuronal acetylcholine receptor subunit beta-2target
DB00898EthanolG protein-activated inward rectifier potassium channel 1target
DB00898EthanolG protein-activated inward rectifier potassium channel 2target
DB00898EthanolVascular cell adhesion protein 1target
DB00898EthanolEquilibrative nucleoside transporter 1target
DB00898EthanolG protein-activated inward rectifier potassium channel 4target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-7target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-9target
DB00898EthanolGamma-aminobutyric acid receptor subunit beta-1target
DB00898EthanolGamma-aminobutyric acid receptor subunit beta-3target
DB00898EthanolGamma-aminobutyric acid receptor subunit beta-2target
DB00898EthanolVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00898EthanolVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00898EthanolAlcohol dehydrogenase 6enzyme
DB00898EthanolNeuronal acetylcholine receptor subunit beta-4target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-3target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-5target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-6target
DB00898EthanolNeuronal acetylcholine receptor subunit beta-3target
DB00898EthanolGamma-aminobutyric acid receptor subunit gamma-1target
DB00898EthanolGamma-aminobutyric acid receptor subunit gamma-3target
DB00898EthanolGamma-aminobutyric acid receptor subunit epsilontarget
DB00898EthanolGamma-aminobutyric acid receptor subunit pitarget
DB00898EthanolGamma-aminobutyric acid receptor subunit thetatarget
DB00898EthanolGamma-aminobutyric acid receptor subunit deltatarget
DB00898EthanolAlcohol dehydrogenase [NADP(+)]enzyme
DB00898EthanolEquilibrative nucleoside transporter 2target
DB00898Ethanol5-hydroxytryptamine receptor 3Etarget
DB00898Ethanol5-hydroxytryptamine receptor 3Btarget
DB00898Ethanol5-hydroxytryptamine receptor 3Dtarget
DB00898Ethanol5-hydroxytryptamine receptor 3Ctarget
DB00898EthanolVoltage-dependent calcium channel gamma-2 subunittarget
DB00898EthanolG protein-activated inward rectifier potassium channel 3target
DB00898EthanolNeural cell adhesion molecule L1target
DB01123ProflavineHTH-type transcriptional regulator QacRtarget
DB01123ProflavineTetR family transcriptional repressor LfrRtarget
DB01718CetrimoniumCyclopropane mycolic acid synthase MmaA2target
DB01718CetrimoniumCyclopropane mycolic acid synthase 1target
DB01744CamphorCamphor 5-monooxygenasetarget
DB01744CamphorTransient receptor potential cation channel subfamily V member 1target
DB01744CamphorTransient receptor potential cation channel subfamily V member 3target
DB01744CamphorTransient receptor potential cation channel subfamily A member 1target
DB01744CamphorTransient receptor potential cation channel subfamily M member 8target
DB03255PhenolNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasetarget
DB03255PhenolSerum albumintarget
DB03843FormaldehydeD-alanyl-D-alanine carboxypeptidasetarget
DB03895Malachite GreenHTH-type transcriptional regulator QacRtarget
DB04209DequaliniumHTH-type transcriptional regulator QacRtarget
DB04209DequaliniumAcriflavine resistance protein Btarget
DB04209DequaliniumE3 ubiquitin-protein ligase XIAPtarget
DB04209DequaliniumcGMP-gated cation channel alpha-1target
DB04209DequaliniumCalcium-activated potassium channel subunit alpha-1target
DB05245Silver sulfadiazineDNAtarget
DB06795MafenideCarbonic anhydrase 6target
DB08604TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH] FabItarget
DB08604TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH]target
DB08604TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH] FabItarget
DB08604TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH]target
DB08604TriclosanEnoyl-[acyl-carrier-protein] reductase [NADPH] FabItarget
DB08604TriclosanNuclear receptor subfamily 1 group I member 2target
DB08604TriclosanAndrogen receptortarget
DB08604TriclosanNuclear receptor subfamily 1 group I member 3target
DB08604TriclosanPeroxisome proliferator-activated receptor gammatarget
DB08604TriclosanThyroid peroxidasetarget
DB11091Hydrogen peroxideGlutathione peroxidase 1enzyme
DB11091Hydrogen peroxideCatalaseenzyme
DB11091Hydrogen peroxideAlkaline phosphatase, placental-likeenzyme
DB11155TriclocarbanEnoyl-[acyl-carrier-protein] reductase [NADPH] FabItarget
DB11155TriclocarbanCytochrome P450 1A1enzyme
DB11155TriclocarbanCytochrome P450 1B1enzyme
DB13154ParachlorophenolSolute carrier organic anion transporter family member 1B3transporter
DB13154ParachlorophenolSodium channel protein type 4 subunit alphatarget
DB13503TyrothricinPhospholipid membranetarget
DB13960BronopolThiol groupstarget
DB11254HexylresorcinolDNA topoisomerase 1target
DB11254HexylresorcinolProtein-glutamine gamma-glutamyltransferase 2target
DB13269Dichlorobenzyl alcoholSodium channel proteintarget
DB05382IodineNADH-ubiquinone oxidoreductase chain 5target
DB02192Phenylethyl alcoholParathion hydrolasetarget
DB03808HexamidineHTH-type transcriptional regulator QacRtarget
DB03808HexamidineHTH-type transcriptional regulator QacRtarget