Anti-Infective Agents, Local

Name
Anti-Infective Agents, Local
Accession Number
DBCAT000103
Description

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.

ATC Classification
Drugs
DrugDrug Description
CetylpyridiniumA compound used to reduce plaque and gingivitis, as well as whiten teeth.
BenzalkoniumAn antiseptic agent used as a preservative in medications or as a disinfectant in cleaning products.
HexachloropheneA chlorinated bisphenol antiseptic used as a surgical scrub and skin cleanser.
BenzethoniumA medication used as to clean hands and clean minor cuts and scrapes.
OctenidineOctenidine is under investigation in clinical trial NCT02697162 (Antiseptic-coated Intermittent Urinary Catheter).
Gramicidin DA bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections.
ClotrimazoleA topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.
Gentian violet cationAn antiseptic violet dye used to prevent various infections, including fungal and bacterial infections.
FurazolidoneFor the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.
BacitracinA cyclic polypeptide antibiotic used to prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections.
SulfacetamideA corticosteroid used to treat inflammatory ocular conditions and acne vulgaris.
NatamycinA macrolide antifungal used to treat fungal infections of the eye.
ChlorhexidineAn antiseptic used to sterilize for surgeries and in healthcare practice, to reduce pocket depth in periodontitis, and to treat gingivitis.
EthanolFor therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical...
ProflavineA topical antiseptic agent used in wound dressings to prevent infections.
CetrimoniumA compound that can be used as a topical antiseptic.
CamphorA compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.
ThymolAn essential oil found in various over-the-counter antibacterial and antifungal products.
PhenolAn antiseptic and disinfectant used in a variety of settings.
FormaldehydeA naturally occurring hazardous organic compound used as a preservative in animal feed, cosmetic products, laboratory procedures, disinfection, and home building products.
Malachite GreenNot Available
DequaliniumA quaternary ammonium cation antimicrobial agent used to treat common infections of the mouth and throat that has been studied in the treatment of vaginal candidiasis.
BithionolBithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the...
Silver sulfadiazineA topical sulfonamide antibiotic that acts on the bacterial cell wall and cell membrane; approved for the treatment of burns.
MafenideAn antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.
Povidone-iodineA topical antiseptic agent used for the treatment and prevention of infection in wounds.
TriclosanAn antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew.
HexetidineAn topical antiseptic agent used for disinfection and prevention of bacterial, fungal and yeast infections of the oral and vaginal mucosa.
Silver nitrateSilver nitrate is an inorganic compound with the chemical formula AgNO3. In its solid form, silver nitrate is coordinated in a trigonal planar arrangement. It is often used as a...
Hydrogen peroxideA compound used as a disinfectant and sterilizer.
ChloroxylenolAn antimicrobial used to treat cuts, bites, stings, abrasions, and used as an antiseptic hand cleaner.
TriclocarbanAn antibacterial agent used in liquid soaps and body washes.
Tea tree oilIndicated for topical use to help protect against infection in minor cuts, scrapes, and burns. No FDA-approved therapeutic indications.
Brilliant green cationAn ingredient used in topical medications to prevent infections of the umbilical cord.
PhenoxyethanolAn antiseptic used as a hand disinfectant or preservative in medications.
AminacrineA highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH...
CetalkoniumAn antiseptic used as a preservative or to treat certain topical infections.
TaurolidineTaurolidine has been investigated for the prevention of Central Venous Catheter, Home Parenteral Nutrition, and Catheter-Related Infections.
ParachlorophenolAn antibacterial agent used to prevent infections in root canals.
BenzododeciniumBenzododecinium is used as an antiseptic/disinfectant compound. It has been marketed as a tincture for antiseptic product for wounds in the Czech Republic.
TyrothricinA topical antibiotic with broad spectrum activity against Gram positive bacteria and some fungal infections.
DibrompropamidineNot Annotated
DecamethoxineNot Annotated
Mercuric chlorideMercury chloride (HgCl2) is a highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a...
NoxytiolinLocal antibacterial that probably acts by releasing formaldehyde in aqueous solutions. It is used for THERAPEUTIC IRRIGATION of infected body cavities - bladder, peritoneum, etc. and as a spray for...
BronopolAn antimicrobial compound used as a biocide and preservative.
Sodium bisulfiteSodium bisulfite has been used externally for parasitic skin diseases and as gastrointestinal antiseptic.
HexylresorcinolAn ingredient used to relieve irritation, pain, and prevent infection.
Dichlorobenzyl alcoholA medication used to treat a sore throat.
Acriflavinium chlorideNot Annotated
AmbazoneNot Annotated
MyristalkoniumNot Annotated
OxyquinolineA medication used in combination with other medications to restore vaginal pH.
ChlorquinaldolChlorquinaldol was used historically as a topical antiseptic agent for skin infections. It maintains use in European countries as a combination vaginal tablet with promestriene for use in the treatment...
IodineAn ingredient of nutritional supplements that is also used for disinfection.
TosylchloramideTosylchloramide, also known as chloramine-T, is a chlorinated and deprotonated sulfonamide used as a mild disinfectant. It is not stable in the water dissolved form.
Phenylethyl alcoholAn antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.
HexamidineNot Available
Carbamide peroxideA medication used to loosen ear wax, whiten teeth, and clean oral wounds.
Drugs & Drug Targets
DrugTargetType
HexachloropheneD-lactate dehydrogenasetarget
HexachloropheneGlutamate dehydrogenase 1, mitochondrialtarget
HexachloropheneSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialtarget
HexachloropheneEstrogen receptor alphatarget
Gramicidin DP-glycoprotein 1transporter
ClotrimazoleIntermediate conductance calcium-activated potassium channel protein 4target
ClotrimazoleCytochrome P450 2D6enzyme
ClotrimazoleCytochrome P450 2C8enzyme
ClotrimazoleCytochrome P450 3A4enzyme
ClotrimazoleCytochrome P450 2B6enzyme
ClotrimazoleP-glycoprotein 1transporter
ClotrimazoleCytochrome P450 2A6enzyme
ClotrimazoleCytochrome P450 2C9enzyme
ClotrimazoleCytochrome P450 2E1enzyme
ClotrimazoleCytochrome P450 3A7enzyme
ClotrimazoleCytochrome P450 51target
ClotrimazoleNuclear receptor subfamily 1 group I member 2target
ClotrimazoleHydroxycarboxylic acid receptor 2target
ClotrimazoleBile salt export pumptransporter
ClotrimazoleSolute carrier organic anion transporter family member 1B1transporter
ClotrimazoleSolute carrier organic anion transporter family member 1B3transporter
ClotrimazoleErgosteroltarget
Gentian violet cationDNAtarget
Gentian violet cationSolute carrier family 22 member 1transporter
FurazolidoneDNAtarget
FurazolidoneAmine oxidase [flavin-containing] Benzyme
FurazolidoneAmine oxidase [flavin-containing] Aenzyme
BacitracinAlpha-2-macroglobulintarget
BacitracinInsulin-degrading enzymetarget
BacitracinC55-isoprenyl pyrophosphatetarget
BacitracinBacitracin transport ATP-binding protein BcrAtransporter
BacitracinBacitracin transport permease protein BCRBtransporter
BacitracinBacitracin transport permease protein BcrCtransporter
SulfacetamideDihydropteroate synthasetarget
SulfacetamideDihydropteroate synthase type-1target
SulfacetamideFolic acid synthesis protein FOL1target
NatamycinErgosteroltarget
NatamycinCytochrome P450 3A4enzyme
ChlorhexidineBacterial outer membranetarget
ChlorhexidineSerum albumincarrier
EthanolGamma-aminobutyric acid receptor subunit alpha-1target
EthanolGlutamate receptor ionotropic, NMDA 3Atarget
EthanolGlycine receptor subunit alpha-1target
EthanolGlycine receptor subunit alpha-2target
EthanolCytochrome P450 2E1enzyme
EthanolCytochrome P450 1A1enzyme
EthanolCytochrome P450 1A2enzyme
EthanolCytochrome P450 2B6enzyme
EthanolCytochrome P450 2C19enzyme
EthanolCytochrome P450 2C9enzyme
EthanolCytochrome P450 3A4enzyme
EthanolCytochrome P450 4A11enzyme
EthanolAlcohol dehydrogenase 1Aenzyme
EthanolAlcohol dehydrogenase 1Benzyme
EthanolAlcohol dehydrogenase 1Cenzyme
EthanolAlcohol dehydrogenase class-3enzyme
EthanolVoltage-dependent L-type calcium channel subunit beta-1target
Ethanol5-hydroxytryptamine receptor 3Atarget
EthanolAlcohol dehydrogenase 4enzyme
EthanolGamma-aminobutyric acid receptor subunit alpha-2target
EthanolNeuronal acetylcholine receptor subunit alpha-10target
EthanolVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
EthanolGamma-aminobutyric acid receptor subunit alpha-5target
EthanolGamma-aminobutyric acid receptor subunit alpha-4target
EthanolAlcohol dehydrogenase class 4 mu/sigma chainenzyme
EthanolGamma-aminobutyric acid receptor subunit alpha-3target
EthanolGlutamate receptor 1target
EthanolVoltage-dependent calcium channel gamma-1 subunittarget
EthanolNeuronal acetylcholine receptor subunit alpha-2target
EthanolGamma-aminobutyric acid receptor subunit alpha-6target
EthanolGlutamate receptor 2target
EthanolGlutamate receptor 4target
EthanolGlutamate receptor 3target
EthanolNeuronal acetylcholine receptor subunit alpha-4target
EthanolNeuronal acetylcholine receptor subunit beta-2target
EthanolG protein-activated inward rectifier potassium channel 1target
EthanolG protein-activated inward rectifier potassium channel 2target
EthanolVascular cell adhesion protein 1target
EthanolEquilibrative nucleoside transporter 1target
EthanolG protein-activated inward rectifier potassium channel 4target
EthanolNeuronal acetylcholine receptor subunit alpha-7target
EthanolNeuronal acetylcholine receptor subunit alpha-9target
EthanolGamma-aminobutyric acid receptor subunit beta-1target
EthanolGamma-aminobutyric acid receptor subunit beta-3target
EthanolGamma-aminobutyric acid receptor subunit beta-2target
EthanolVoltage-dependent L-type calcium channel subunit alpha-1Starget
EthanolVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
EthanolAlcohol dehydrogenase 6enzyme
EthanolNeuronal acetylcholine receptor subunit beta-4target
EthanolNeuronal acetylcholine receptor subunit alpha-3target
EthanolNeuronal acetylcholine receptor subunit alpha-5target
EthanolNeuronal acetylcholine receptor subunit alpha-6target
EthanolNeuronal acetylcholine receptor subunit beta-3target
EthanolGamma-aminobutyric acid receptor subunit gamma-1target
EthanolGamma-aminobutyric acid receptor subunit gamma-3target
EthanolGamma-aminobutyric acid receptor subunit epsilontarget
EthanolGamma-aminobutyric acid receptor subunit pitarget
EthanolGamma-aminobutyric acid receptor subunit thetatarget
EthanolGamma-aminobutyric acid receptor subunit deltatarget
EthanolAlcohol dehydrogenase [NADP(+)]enzyme
EthanolEquilibrative nucleoside transporter 2target
Ethanol5-hydroxytryptamine receptor 3Etarget
Ethanol5-hydroxytryptamine receptor 3Btarget
Ethanol5-hydroxytryptamine receptor 3Dtarget
Ethanol5-hydroxytryptamine receptor 3Ctarget
EthanolVoltage-dependent calcium channel gamma-2 subunittarget
EthanolG protein-activated inward rectifier potassium channel 3target
EthanolNeural cell adhesion molecule L1target
ProflavineDNAtarget
ProflavineProthrombintarget
ProflavineHTH-type transcriptional regulator QacRtarget
ProflavineTetR family transcriptional repressor LfrRtarget
CetrimoniumCyclopropane mycolic acid synthase MmaA2target
CetrimoniumCyclopropane mycolic acid synthase 1target
CamphorCamphor 5-monooxygenasetarget
CamphorTransient receptor potential cation channel subfamily V member 1target
CamphorTransient receptor potential cation channel subfamily V member 3target
CamphorTransient receptor potential cation channel subfamily A member 1target
CamphorTransient receptor potential cation channel subfamily M member 8target
PhenolThermolysintarget
PhenolLysozymetarget
PhenolNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasetarget
PhenolSerum albumintarget
FormaldehydeD-alanyl-D-alanine carboxypeptidasetarget
Malachite GreenHTH-type transcriptional regulator QacRtarget
DequaliniumHTH-type transcriptional regulator QacRtarget
DequaliniumAcriflavine resistance protein Btarget
DequaliniumE3 ubiquitin-protein ligase XIAPtarget
DequaliniumcGMP-gated cation channel alpha-1target
DequaliniumCalcium-activated potassium channel subunit alpha-1target
Silver sulfadiazineDNAtarget
MafenideCarbonic anhydrase 6target
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH] FabItarget
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH]target
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH] FabItarget
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH]target
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADPH] FabItarget
TriclosanNuclear receptor subfamily 1 group I member 2target
TriclosanAndrogen receptortarget
TriclosanNuclear receptor subfamily 1 group I member 3target
TriclosanPeroxisome proliferator-activated receptor gammatarget
TriclosanThyroid peroxidasetarget
Hydrogen peroxideGlutathione peroxidase 1enzyme
Hydrogen peroxideCatalaseenzyme
Hydrogen peroxideAlkaline phosphatase, placental-likeenzyme
TriclocarbanEnoyl-[acyl-carrier-protein] reductase [NADPH] FabItarget
TriclocarbanCytochrome P450 1A1enzyme
TriclocarbanCytochrome P450 1B1enzyme
ParachlorophenolSolute carrier organic anion transporter family member 1B3transporter
ParachlorophenolSodium channel protein type 4 subunit alphatarget
TyrothricinAcetylcholinesterasetarget
TyrothricinBeta-galactosidasetarget
TyrothricinPhospholipid membranetarget
BronopolThiol groupstarget
HexylresorcinolDNA topoisomerase 1target
HexylresorcinolProtein-glutamine gamma-glutamyltransferase 2target
HexylresorcinolTyrosinasetarget
Dichlorobenzyl alcoholSodium channel proteintarget
IodineSodium/iodide cotransportertransporter
IodineSerum albumincarrier
IodineThyroglobulincarrier
IodineThyroid peroxidaseenzyme
IodineSodium/iodide cotransportertarget
IodinePendrintransporter
IodineMicrobial proteinstarget
Phenylethyl alcoholParathion hydrolasetarget
HexamidineHTH-type transcriptional regulator QacRtarget
HexamidineHTH-type transcriptional regulator QacRtarget