Phenoxyethanol

Identification

Name
Phenoxyethanol
Accession Number
DB11304
Type
Small Molecule
Groups
Approved
Description

Phenoxyethanol is a colorless liquid with a pleasant odor. It is a glycol ether used as a perfume fixative, insect repellent, antiseptic, solvent, preservative, and also as an anesthetic in fish aquaculture. Phenoxyethanol is an ether alcohol with aromatic properties. It is both naturally found and manufactured synthetically. Demonstrating antimicrobial ability, phenoxyethanol acts as an effective preservative in pharmaceuticals, cosmetics and lubricants [5].

Phenoxyethanol (EU), or PE, is the most commonly used globally-approved preservative in personal care formulations. It is very easy to use in various types of formulations and is chemically stable. Phenoxyethanol is a colorless, clear, oily liquid with a faint aromatic odor at room temperature and a low water solubility and evaporation rate. It is produced by reacting phenol (EU) and ethylene oxide (EU) at a high temperature and pressure. This substance occurs naturally in green tea (EU) [6].

According to the European Union Cosmetics Regulation (EC) n.1223/2009, phenoxyethanol is authorized as a preservative in cosmetic formulations at a maximum concentration of 1.0% [8].

Phenoxyethanol has been classified as an antimicrobial and preservative by Health Canada [7]. It has also been used in vaccines and shown to inactivate bacteria, and several types of yeast [2].

Structure
Thumb
Synonyms
  • 1-Hydroxy-2-phenoxyethane
  • 2-Hydroxyethyl phenyl ether
  • 2-phenoxyethanol
  • 2-Phenoxyethyl alcohol
  • beta-Hydroxyethyl phenyl ether
  • Ethylene glycol monophenyl ether
  • Phenoxytol
  • Phenyl cellosolve
  • Phenylmonoglycol ether
External IDs
FEMA NO. 4620
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Grime Eater Lotion Soap 2.5%Soap2.5 %TopicalGrime Eater Products Ltd.1988-12-312005-06-17Canada
Lanohex Nettoyeur Pour LA Peau 1.7%Liquid1.7 %TopicalRougier Pharma Division Of Ratiopharm Inc1960-12-312003-09-22Canada
Lanohex Shp 1.7%Shampoo1.7 %TopicalRougier Pharma Division Of Ratiopharm Inc1960-12-312000-09-07Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Acropole BleuPhenoxyethanol (.45 %) + Chloroxylenol (.15 %)JellyTopicalParall LtÉe1997-10-012001-07-23Canada
Cosmos HvPhenoxyethanol (.45 %) + Chloroxylenol (.15 %)LiquidTopicalParall LtÉe1996-12-182004-05-25Canada
Manugel 85Phenoxyethanol (.3 g/500mL) + Ethanol (400 mL/500mL)GelTopicalLaboratoires Anios2014-04-01Not applicableUs
MarcorodexPhenoxyethanol (1 g) + Benzethonium chloride (0.13 g)LiquidTopicalRougier Pharma Division Of Ratiopharm Inc1996-12-102009-08-04Canada
MicroPhenoxyethanol (.45 %) + Chloroxylenol (.15 %)GelTopicalParall LtÉe1997-10-152001-07-23Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
HydroGold 9Phenoxyethanol (.5 mg/100mg) + Acetyl hexapeptide-8 (.01 mg/100mg) + Adenosine (.04 mg/100mg) + Allantoin (.2 mg/100mg) + Sodium benzoate (.5 mg/100mg) + Butylene Glycol (2 mg/100mg) + Castor oil (.4 mg/100mg) + Dimethicone (.01 mg/100mg) + Glycerin (20 mg/100mg) + Gold (.0001 mg/100mg) + Nicotinamide (2 mg/100mg) + Potassium Chloride (.01 mg/100mg) + Titanium dioxide (.43 mg/100mg) + Xanthan gum (.5 mg/100mg)PatchTopicalBhmbg Global Branding Inc.2018-03-092019-12-31Us
Categories
UNII
HIE492ZZ3T
CAS number
122-99-6
Weight
Average: 138.166
Monoisotopic: 138.068079562
Chemical Formula
C8H10O2
InChI Key
QCDWFXQBSFUVSP-UHFFFAOYSA-N
InChI
InChI=1S/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H2
IUPAC Name
2-phenoxyethan-1-ol
SMILES

Pharmacology

Indication

Antimicrobial agent used as a preservative in cosmetics [4], [5], [8].

Pharmacodynamics

This substance has broad-spectrum antimicrobial activity against bacteria, yeasts, and mold [6].

Mechanism of action

Phenoxyethanol has antibacterial properties and is effective against strains of Pseudomonas aeruginosa even in the presence of 20% serum. It not as effective against Proteus vulgaris, other gram-negative organisms, and gram-positive organisms. Phenoxyethanol has been used as a preservative at a concentration of 1%. A wider spectrum of antimicrobial activity is achieved with preservative mixtures of phenoxyethanol and hydroxybenzoates. Phenoxyethanol may be used as a 2.2% solution or a 2% cream for the treatment of superficial wounds, burns, or abscesses infected by Pseudomonas aeruginosa. In skin infection, derivatives of phenoxyethanol are used in combination with either cyclic acid or zinc undecenoate [7].

Absorption
Not Available
Volume of distribution

A pharmacokinetic study of phenoxyethanol was performed using a mass spectrometry model for simultaneous analysis of phenoxyethanol (PE) and its major metabolite, phenoxyacetic acid (PAA), in rat plasma, urine, and 7 different tissues [10].

The absolute topical bioavailability of PE was 75.4% and 76.0% for emulsion and lotion, respectively. Conversion of PE to PAA was extensive, with the average AUCPAA-to-AUCPE ratio being 4.4 and 5.3 for emulsion and lotion, respectively. The steady-state tissue-to-plasma PE concentration ratio (Kp) was higher than unity for kidney, spleen, heart, brain, and testis and was lower (0.6) for lung and liver, while the metabolite Kp ratio was higher than unity for kidney, liver, lung, and testis and was lower (0.3) for other tissues [10].

Protein binding
Not Available
Metabolism

The fate of phenoxyethanol in rats and humans has been investigated [4]. The rate of intestinal absorption was rapid, with 60-70% of the excreted (14)C detected at 3 hours and > 95% of the total 4-day urinary (14)C detected within the first 24 hr. Trace amounts of radioactivity were detected in feces. Four days after dosing, only trace amounts of radioactivity remained in the carcass, primarily in the liver (< 0.2% of the dose), fat and muscle. At the 4 day point, the (14)C concentration in blood was measured to be only 0.001 [4].

The major metabolite of phenoxyethanol is phenoxyacetic acid [10].

Route of elimination

The fate of phenoxyethanol in rats and humans has been investigated. More than 90% of an oral dose of 16, 27 or 160 mg/kg body weight of (2-(14)C)phenoxyethanol administered to male Colworth rats by was excreted in the urine within 24 hours of administration. A female rat also excreted about 90% of a dose of 27 mg/kg body weight in the urine within 24 hours. About 2% and 1.3% of the ingested dose was recovered from the exhaled air of female and male rats, respectively [4].

Half life
Not Available
Clearance
Not Available
Toxicity

LC50 oral, rat; 1980 mg/kg [MSDS]. LD50 Rabbit dermal 2250 mg/kg [4].

2-Phenoxyethanol (PhE) has been shown to induce hepatotoxicity, renal toxicity, and hemolysis at dosages ≥ 400 mg/kg/day in subchronic and chronic studies in multiple species [3].

The major hazards encountered in the use and handling of 2-phenoxyethanol stem from its toxicologic properties. Toxic by all routes (inhalation, ingestion, and dermal contact), exposure to this very faintly aromatic, colorless, oily liquid may occur from its use as a fixative for cosmetics, perfumes, and soaps; as a bactericide and insect repellant; as a solvent for cellulose acetate,dyes, stamp pad, ball point, and specialty inks; as a chemical intermediate for carboxylic acid esters (eg, acrylate, maleate) and polymers (eg, formaldehyde, melamine); and as a preservative for human specimens used for dissection and demonstrations in anatomical studies. Effects resulting from exposure to this substance can include eye irritation, headache, tremors, and central nervous system depression. If contact with the eyes occurs, irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes, and wash exposed skin thoroughly with soap and water. 2-Phenoxyethanol must be preheated before ignition can occur [7].

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Phenoxyethanol.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Phenoxyethanol.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Phenoxyethanol.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Phenoxyethanol.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Phenoxyethanol.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Phenoxyethanol.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Phenoxyethanol.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Phenoxyethanol.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Phenoxyethanol.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Phenoxyethanol.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Phenoxyethanol.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Phenoxyethanol.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Phenoxyethanol.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Phenoxyethanol.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Phenoxyethanol.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Phenoxyethanol.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Azaperone.Investigational, Vet Approved
AzelastinePhenoxyethanol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Phenoxyethanol.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Phenoxyethanol.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Benperidol.Approved, Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Brexpiprazole is combined with Phenoxyethanol.Approved, Investigational
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Phenoxyethanol.Approved, Illicit, Investigational
BromisovalThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Bromperidol.Approved, Investigational
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Phenoxyethanol.Approved, Investigational, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Phenoxyethanol.Approved, Investigational
BuprenorphinePhenoxyethanol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Phenoxyethanol.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Phenoxyethanol.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Phenoxyethanol.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Phenoxyethanol.Approved, Withdrawn
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Phenoxyethanol.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Phenoxyethanol.Approved, Illicit, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Canertinib is combined with Phenoxyethanol.Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Phenoxyethanol.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenoxyethanol.Illicit, Investigational, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Phenoxyethanol.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Phenoxyethanol.Approved, Illicit, Investigational, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Phenoxyethanol.Approved, Illicit, Investigational
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Phenoxyethanol.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Phenoxyethanol.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Phenoxyethanol.Approved, Investigational, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Phenoxyethanol.Approved, Investigational, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Phenoxyethanol.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Phenoxyethanol.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Citalopram.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Phenoxyethanol.Approved
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Phenoxyethanol.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Phenoxyethanol.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Phenoxyethanol.Approved, Investigational, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Clonazepam is combined with Phenoxyethanol.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Phenoxyethanol.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Phenoxyethanol.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Clothiapine.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Phenoxyethanol.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Phenoxyethanol.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Cyclizine is combined with Phenoxyethanol.Approved
CyclopropaneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Cyclopropane.Experimental
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Phenoxyethanol.Approved
DantroleneThe risk or severity of adverse effects can be increased when Dantrolene is combined with Phenoxyethanol.Approved, Investigational
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Phenoxyethanol.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Dapoxetine.Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Deramciclane is combined with Phenoxyethanol.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Phenoxyethanol.Approved
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Phenoxyethanol.Approved, Investigational
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Phenoxyethanol.Approved, Investigational
DetomidineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Detomidine.Vet Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Phenoxyethanol.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Phenoxyethanol.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Phenoxyethanol.Approved, Illicit, Investigational, Withdrawn
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Phenoxyethanol.Approved, Illicit, Investigational, Vet Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Difenoxin is combined with Phenoxyethanol.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Phenoxyethanol.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Phenoxyethanol.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Phenoxyethanol.Experimental, Illicit
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Phenoxyethanol.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Phenoxyethanol.Approved, Investigational
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Phenoxyethanol.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Phenoxyethanol.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Phenoxyethanol.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Phenoxyethanol.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Phenoxyethanol.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Eltanolone.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Phenoxyethanol.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Phenoxyethanol.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Phenoxyethanol.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Phenoxyethanol.Approved, Investigational
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Phenoxyethanol.Approved, Illicit, Withdrawn
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Phenoxyethanol.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Phenoxyethanol.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Ethyl chloride.Approved, Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Phenoxyethanol.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Phenoxyethanol.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Phenoxyethanol.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Phenoxyethanol.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Phenoxyethanol.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Phenoxyethanol.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Ezogabine is combined with Phenoxyethanol.Approved, Investigational
FelbamateThe risk or severity of adverse effects can be increased when Felbamate is combined with Phenoxyethanol.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Phenoxyethanol.Approved, Illicit, Withdrawn
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Phenoxyethanol.Approved, Investigational
FlibanserinThe risk or severity of adverse effects can be increased when Flibanserin is combined with Phenoxyethanol.Approved, Investigational
FluanisoneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Phenoxyethanol.Approved, Illicit
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Phenoxyethanol.Approved, Illicit
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Phenoxyethanol.Approved, Investigational, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Phenoxyethanol.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Phenoxyethanol.Approved, Illicit, Investigational
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Phenoxyethanol.Approved, Illicit, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Gabapentin Enacarbil is combined with Phenoxyethanol.Approved, Investigational
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Phenoxyethanol.Approved, Illicit, Investigational
GepironeThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Phenoxyethanol.Approved, Illicit
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Phenoxyethanol.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Phenoxyethanol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Phenoxyethanol.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Phenoxyethanol.Approved, Illicit, Investigational
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Phenoxyethanol.Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Phenoxyethanol.Approved, Illicit
IloperidoneThe risk or severity of adverse effects can be increased when Iloperidone is combined with Phenoxyethanol.Approved
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Phenoxyethanol.Approved
IndalpineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Indalpine.Investigational, Withdrawn
IndiplonThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Indiplon.Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Phenoxyethanol.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Phenoxyethanol.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Phenoxyethanol.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Phenoxyethanol.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Phenoxyethanol.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Levocabastine.Approved, Investigational
LevocetirizineThe risk or severity of adverse effects can be increased when Levocetirizine is combined with Phenoxyethanol.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Phenoxyethanol.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Levomilnacipran.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Phenoxyethanol.Approved
Lithium cationThe risk or severity of adverse effects can be increased when Lithium is combined with Phenoxyethanol.Experimental
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Phenoxyethanol.Illicit
LofexidineThe therapeutic efficacy of Phenoxyethanol can be increased when used in combination with Lofexidine.Approved, Investigational
LoprazolamThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Loprazolam.Experimental
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Phenoxyethanol.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Lormetazepam.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Phenoxyethanol.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Phenoxyethanol.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Phenoxyethanol.Approved, Investigational
MebicarThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Mebicar.Experimental
MedazepamThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Phenoxyethanol.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Phenoxyethanol.Approved, Investigational
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Phenoxyethanol.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Phenoxyethanol.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Phenoxyethanol.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Phenoxyethanol.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Phenoxyethanol.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Phenoxyethanol.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Phenoxyethanol.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Phenoxyethanol.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Phenoxyethanol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Phenoxyethanol.Approved
MethotrimeprazinePhenoxyethanol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved, Investigational
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Phenoxyethanol.Approved, Investigational, Vet Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Phenoxyethanol.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Phenoxyethanol.Approved
MetyrosinePhenoxyethanol may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Phenoxyethanol.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Milnacipran.Approved, Investigational
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.Approved, Investigational
MirtazapinePhenoxyethanol may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Phenoxyethanol.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Phenoxyethanol.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Phenoxyethanol.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Phenoxyethanol.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Phenoxyethanol.Approved, Vet Approved
NordazepamThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Nordazepam.Approved
NorfluraneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Norflurane.Approved, Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Phenoxyethanol.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Phenoxyethanol.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Phenoxyethanol.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Phenoxyethanol.Approved, Illicit
OrphenadrinePhenoxyethanol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Phenoxyethanol.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Phenoxyethanol.Approved
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Phenoxyethanol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Phenoxyethanol.Approved, Investigational
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Phenoxyethanol.Approved
ParaldehydePhenoxyethanol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Phenoxyethanol.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Phenoxyethanol.Approved, Investigational, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.Approved
PerazineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Perazine.Approved, Investigational
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Phenoxyethanol.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Phenoxyethanol.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Phenoxyethanol.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Phenazocine.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Phenibut.Experimental
PhenoperidineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Phenoperidine.Experimental
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Phenoxyethanol.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Phenoxyethanol.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Phenoxyethanol.Approved, Investigational
PipotiazineThe risk or severity of adverse effects can be increased when Pipotiazine is combined with Phenoxyethanol.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Piritramide.Approved, Investigational
PizotifenThe risk or severity of adverse effects can be increased when Pizotifen is combined with Phenoxyethanol.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Phenoxyethanol.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Phenoxyethanol.Approved, Illicit
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Phenoxyethanol.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Primidone is combined with Phenoxyethanol.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Phenoxyethanol.Approved, Investigational, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Phenoxyethanol.Approved, Vet Approved
PropanididThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Phenoxyethanol.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Phenoxyethanol.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Phenoxyethanol.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Phenoxyethanol.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Phenoxyethanol.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Phenoxyethanol.Approved, Illicit
QuinisocaineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Ramelteon is combined with Phenoxyethanol.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Phenoxyethanol.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Phenoxyethanol.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Phenoxyethanol.Approved, Investigational
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Phenoxyethanol.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Romifidine.Vet Approved
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Phenoxyethanol.Approved
RotigotinePhenoxyethanol may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Phenoxyethanol.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Phenoxyethanol.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Phenoxyethanol.Approved, Investigational, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Phenoxyethanol.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.Approved
StiripentolThe risk or severity of adverse effects can be increased when Stiripentol is combined with Phenoxyethanol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Phenoxyethanol.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Phenoxyethanol.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Sultopride.Experimental
SuvorexantPhenoxyethanol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Tasimelteon is combined with Phenoxyethanol.Approved, Investigational
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Phenoxyethanol.Approved, Investigational
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Phenoxyethanol.Approved, Investigational
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Phenoxyethanol.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Phenoxyethanol.Investigational
ThalidomidePhenoxyethanol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Phenoxyethanol.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Phenoxyethanol.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Phenoxyethanol.Approved, Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Phenoxyethanol.Approved
TiagabineThe risk or severity of adverse effects can be increased when Tiagabine is combined with Phenoxyethanol.Approved, Investigational
TiaprideThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Tiapride.Approved, Investigational
TiletamineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Tilidine.Experimental
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Phenoxyethanol.Approved, Investigational
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Phenoxyethanol.Approved, Withdrawn
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Phenoxyethanol.Approved, Investigational
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Phenoxyethanol.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Phenoxyethanol.Approved, Investigational
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Trichloroethylene.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Phenoxyethanol.Approved, Investigational
TrifluperidolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Phenoxyethanol.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Phenoxyethanol.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Phenoxyethanol.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Veralipride.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Vigabatrin is combined with Phenoxyethanol.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Phenoxyethanol.Approved, Investigational
XenonThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Phenoxyethanol.Approved, Illicit, Investigational
ZimelidineThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Phenoxyethanol.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Zolazepam.Vet Approved
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Phenoxyethanol.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Phenoxyethanol.Approved, Investigational, Withdrawn
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Phenoxyethanol.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Morton WE: Occupational phenoxyethanol neurotoxicity: a report of three cases. J Occup Med. 1990 Jan;32(1):42-5. [PubMed:2324842]
  2. Lowe I, Southern J: The antimicrobial activity of phenoxyethanol in vaccines. Lett Appl Microbiol. 1994 Feb;18(2):115-6. [PubMed:7764595]
  3. Troutman JA, Rick DL, Stuard SB, Fisher J, Bartels MJ: Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment. Regul Toxicol Pharmacol. 2015 Nov;73(2):530-43. doi: 10.1016/j.yrtph.2015.07.012. Epub 2015 Jul 16. [PubMed:26188115]
  4. Phenoxyethanol [Link]
  5. Phenoxyethanol - Brumer [Link]
  6. Phenoxyethanol: A Globally-Approved Preservative [Link]
  7. Health Canada: Phenoxyethanol [Link]
  8. Opinion on Phenoxyethanol - EU Law and Publications [Link]
  9. pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment [Link]
  10. Simultaneous determination of phenoxyethanol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC–MS/MS with polarity switching: Application to ADME studies [Link]
External Links
Human Metabolome Database
HMDB0041607
PubChem Compound
31236
PubChem Substance
347827964
ChemSpider
13848467
ChEBI
64275
ChEMBL
CHEMBL1229846
HET
268
Wikipedia
Phenoxyethanol
PDB Entries
2rbr
MSDS
Download (37.8 KB)

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
JellyTopical
LiquidTopical
SoapTopical2.5 %
PatchTopical
LiquidTopical1.7 %
ShampooTopical1.7 %
GelTopical
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
PropertyValueSource
melting point (°C)13MSDS
boiling point (°C)245MSDS
water solubility24g/L at 20°CMSDS
Predicted Properties
PropertyValueSource
Water Solubility24.1 mg/mLALOGPS
logP1.22ALOGPS
logP1.13ChemAxon
logS-0.76ALOGPS
pKa (Strongest Acidic)15.1ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area29.46 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity38.81 m3·mol-1ChemAxon
Polarizability14.91 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-0006-9100000000-b40ca28428e0018311ea
GC-MS Spectrum - EI-BGC-MSsplash10-0006-9100000000-f8c06faa8eb8d23a95c1
GC-MS Spectrum - EI-BGC-MSsplash10-0006-9100000000-7b2a4d4d9b09c7b78741
GC-MS Spectrum - EI-BGC-MSsplash10-0006-9100000000-9bb41b75d1ad646b88f0
GC-MS Spectrum - CI-BGC-MSsplash10-000i-0900000000-9421e4830e44b3388570
GC-MS Spectrum - EI-BGC-MSsplash10-0006-9000000000-f53c3891b4914dd833e8
GC-MS Spectrum - EI-BGC-MSsplash10-0006-9200000000-b5db9ef1d198ca188c7c
GC-MS Spectrum - EI-BGC-MSsplash10-0006-9100000000-ab2d6abdcb42c8020070
GC-MS Spectrum - EI-BGC-MSsplash10-0006-9000000000-480278f55ce8ffc42edb
Mass Spectrum (Electron Ionization)MSsplash10-0006-9100000000-9c2de92b427cc8e30262
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Phenol ethers
Sub Class
Not Available
Direct Parent
Phenol ethers
Alternative Parents
Phenoxy compounds / Alkyl aryl ethers / Primary alcohols / Hydrocarbon derivatives
Substituents
Phenoxy compound / Phenol ether / Alkyl aryl ether / Monocyclic benzene moiety / Ether / Organic oxygen compound / Hydrocarbon derivative / Primary alcohol / Organooxygen compound / Alcohol
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
aromatic ether, primary alcohol, hydroxyether (CHEBI:64275)

Drug created on December 03, 2015 09:52 / Updated on August 02, 2018 06:23