Tetanus

Also known as: Tetanus NOS

DrugDrug NameDrug Description
DB01053BenzylpenicillinBenzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as *Streptococcus pneumoniae*, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (*S. agalactiae*), *S. viridans*, and *Enterococcus faecalis*. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as *Bacillus anthracis*, *Corynebacterium diphtheriae*, and *Erysipelothrix rhusiopathiae*. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by *Neisseria meningitidis* and *Pasteurella*. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
DB00477ChlorpromazineThe prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium sulfate filtration and precipation.
DB09877Corynebacterium diphtheriae*Corynebacterium diphtheriae* toxin is extracted from the pathogenic actinobacterium *C. diphtheriae* that causes diphtheria. The bacteria culture is grown in a medium and through purification, diphtheria toxin is detoxified with formaldehyde and diafiltered. The vaccine is intramuscularly administered to provide active immunization against diphtheria in infants and children.
DB00829DiazepamA benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 [L5200]. Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect [L5200]. This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy [L5200].
DB00423MethocarbamolMethocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether.[A178450] Methocarbamol tablets and intramuscular injections are prescription medicines indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.[Label,L6268] In Canada, methocarbamol can be sold as an over the counter oral medicine at a lower dose that may be combined with [acetaminophen] or [ibuprofen].[L6295] A combination product with [acetylsalicylic acid] and [codeine] is available in Canada by prescription.[L6295] Methocarbamol was FDA approved on 16 July 1957.[L6265]
DB00916MetronidazoleA nitroimidazole used to treat amebiasis; vaginitis; trichomonas infections; giardiasis; anaerobic bacteria; and treponemal infections. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
DB11604Tetanus Immune GlobulinTetanus Immune Globulin is manufactured from human plasma [FDA Label]. It contains antibodies against tetanus toxoid and is primarily used as prophylaxis against tetanus in wounded patients.
DrugDrug NameTargetType
DB01053BenzylpenicillinSolute carrier family 22 member 5transporter
DB01053BenzylpenicillinSolute carrier family 15 member 1transporter
DB01053BenzylpenicillinSolute carrier family 15 member 2transporter
DB01053BenzylpenicillinSolute carrier family 22 member 6transporter
DB01053BenzylpenicillinSolute carrier family 22 member 8transporter
DB01053BenzylpenicillinSolute carrier family 22 member 4transporter
DB01053BenzylpenicillinSolute carrier family 22 member 11transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 2B1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 4A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 3A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 1B1transporter
DB01053BenzylpenicillinPenicillin-binding protein 3target
DB01053BenzylpenicillinBeta-lactamase TEMtarget
DB01053BenzylpenicillinSolute carrier family 22 member 8target
DB01053BenzylpenicillinSolute carrier family 15 member 1target
DB01053BenzylpenicillinSolute carrier family 15 member 2target
DB00477ChlorpromazineD(2) dopamine receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Atarget
DB00477ChlorpromazineCytochrome P450 2D6enzyme
DB00477ChlorpromazineCholinesteraseenzyme
DB00477ChlorpromazineCytochrome P450 1A2enzyme
DB00477ChlorpromazineSerum albumincarrier
DB00477ChlorpromazineMultidrug resistance protein 1transporter
DB00477ChlorpromazineD(1A) dopamine receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 1Atarget
DB00477ChlorpromazineAlpha-1A adrenergic receptortarget
DB00477ChlorpromazineAlpha-1B adrenergic receptortarget
DB00477ChlorpromazineCytochrome P450 2E1enzyme
DB00477ChlorpromazineCytochrome P450 3A4enzyme
DB00477ChlorpromazineHistamine H1 receptortarget
DB00477ChlorpromazinePotassium voltage-gated channel subfamily H member 2target
DB00477ChlorpromazineD(1) dopamine receptortarget
DB00477ChlorpromazineD(3) dopamine receptortarget
DB00477ChlorpromazineD(4) dopamine receptortarget
DB00477ChlorpromazineD(1B) dopamine receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Ctarget
DB00477Chlorpromazine5-hydroxytryptamine 2 receptortarget
DB00477ChlorpromazineAlpha-1 adrenergic receptorstarget
DB00477ChlorpromazineAlpha-2 adrenergic receptorstarget
DB00477ChlorpromazineMuscarinic acetylcholine receptor M1target
DB00477ChlorpromazineMuscarinic acetylcholine receptor M3target
DB00477ChlorpromazineSphingomyelin phosphodiesterasetarget
DB00477ChlorpromazineCalmodulintarget
DB00477Chlorpromazinealpha1-acid glycoproteintarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 6target
DB00477Chlorpromazine5-hydroxytryptamine receptor 7target
DB00477ChlorpromazineHistamine H4 receptortarget
DB00477ChlorpromazineBile salt export pumptransporter
DB00829DiazepamTranslocator proteintarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB00829DiazepamCytochrome P450 3A4enzyme
DB00829DiazepamSerum albumincarrier
DB00829DiazepamCytochrome P450 2C9enzyme
DB00829DiazepamCytochrome P450 2C19enzyme
DB00829DiazepamCytochrome P450 3A5enzyme
DB00829DiazepamCytochrome P450 3A7enzyme
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit deltatarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit pitarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit thetatarget
DB00829DiazepamMultidrug resistance protein 1transporter
DB00829DiazepamCytochrome P450 2B6enzyme
DB00829DiazepamProstaglandin G/H synthase 1enzyme
DB00829DiazepamCytochrome P450 2C18enzyme
DB00829DiazepamCytochrome P450 2C8enzyme
DB00829DiazepamCytochrome P450 2E1enzyme
DB00829DiazepamGABA-A receptor (anion channel)target
DB00423MethocarbamolCarbonic anhydrase 1target
DB00916MetronidazoleIron hydrogenase 1target
DB00916MetronidazoleDNAtarget
DB00916MetronidazoleOxygen-insensitive NADPH nitroreductasetarget
DB00916MetronidazoleCytochrome P450 2C9enzyme
DB00916MetronidazoleCytochrome P450 3A4enzyme
DB00916MetronidazoleCytochrome P450 2C8enzyme
DB00916MetronidazoleLanosterol 14-alpha demethylasetarget
DB00916MetronidazoleUDP-glucuronosyltransferase 1-1enzyme
DB11604Tetanus Immune GlobulinTetanus toxintarget
DrugDrug NamePhaseStatusCount
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)1 / 2Active Not Recruiting1
DB10788Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)2Completed1
DB10790Bordetella pertussis fimbriae 2/3 antigen2Completed1
DB10789Bordetella pertussis pertactin antigen2Completed1
DB10787Bordetella pertussis toxoid antigen (glutaraldehyde inactivated)2Completed1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)2Completed2
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)2Recruiting1
DB10584Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)2Completed1
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen2Completed1
DB11627Hepatitis B Vaccine (Recombinant)2Completed2
DB13890Meningococcal polysaccharide vaccine group C2Completed1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen2Completed1
DB10795Poliovirus type 1 antigen (formaldehyde inactivated)2Completed2
DB10796Poliovirus type 2 antigen (formaldehyde inactivated)2Completed1
DB10797Poliovirus type 3 antigen (formaldehyde inactivated)2Completed1
DB10276Rotavirus Vaccine2Completed1
DB06361rsPSMA Vaccine2Completed1
DB14618INFLUENZA A VIRUS A/BRISBANE/59/2007(H1N1) HEMAGGLUTININ ANTIGEN (FORMALDEHYDE INACTIVATED)2 / 3Withdrawn1
DB14617INFLUENZA A VIRUS A/URUGUAY/716/2007(H3N2) HEMAGGLUTININ ANTIGEN (FORMALDEHYDE INACTIVATED)2 / 3Withdrawn1
DB14385Influenza b virus b/brisbane/60/2008 hemagglutinin antigen (formaldehyde inactivated)2 / 3Withdrawn1
DB10788Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)3Completed4
DB10790Bordetella pertussis fimbriae 2/3 antigen3Completed2
DB10789Bordetella pertussis pertactin antigen3Completed2
DB10787Bordetella pertussis toxoid antigen (glutaraldehyde inactivated)3Completed2
DB11121Chloroxylenol3Completed1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)3Completed15
DB10584Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)3Completed5
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen3Active Not Recruiting1
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen3Completed3
DB10990Haemophilus influenzae type b strain 20752 capsular polysaccharide tetanus toxoid conjugate antigen3Completed11
DB11627Hepatitis B Vaccine (Recombinant)3Completed2
DB10300Human papillomavirus type 11 L1 capsid protein antigen3Completed1
DB14618INFLUENZA A VIRUS A/BRISBANE/59/2007(H1N1) HEMAGGLUTININ ANTIGEN (FORMALDEHYDE INACTIVATED)3Completed1
DB14617INFLUENZA A VIRUS A/URUGUAY/716/2007(H3N2) HEMAGGLUTININ ANTIGEN (FORMALDEHYDE INACTIVATED)3Completed1
DB14385Influenza b virus b/brisbane/60/2008 hemagglutinin antigen (formaldehyde inactivated)3Completed1
DB10315Measles virus strain enders' attenuated edmonston live antigen3Completed1
DB13890Meningococcal polysaccharide vaccine group C3Completed1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen3Completed1
DB10795Poliovirus type 1 antigen (formaldehyde inactivated)3Completed4
DB10796Poliovirus type 2 antigen (formaldehyde inactivated)3Completed2
DB10797Poliovirus type 3 antigen (formaldehyde inactivated)3Completed2
DB10276Rotavirus Vaccine3Completed2
DB10286Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen3Completed1
DB10318Varicella Zoster Vaccine (Live/Attenuated)3Completed1
DB09145Water3Completed1
DB10788Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)4Completed1
DB10790Bordetella pertussis fimbriae 2/3 antigen4Completed1
DB10789Bordetella pertussis pertactin antigen4Completed1
DB10787Bordetella pertussis toxoid antigen (glutaraldehyde inactivated)4Completed1
DB01114Chlorphenamine4Completed1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)4Completed10
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)4Terminated1
DB00318Codeine4Completed1
DB10584Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)4Completed3
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen4Completed1
DB10989Hepatitis A Vaccine4Terminated1
DB10061Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine4Completed1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen4Completed2
DB15274Pertussis vaccine4Completed1
DB10795Poliovirus type 1 antigen (formaldehyde inactivated)4Completed1
DB10796Poliovirus type 2 antigen (formaldehyde inactivated)4Completed1
DB10797Poliovirus type 3 antigen (formaldehyde inactivated)4Completed1
DB10319Streptococcus pneumoniae type 1 capsular polysaccharide antigen4Completed1
DB10293Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen4Completed1
DB11604Tetanus Immune Globulin4Terminated1
DB00656Trazodone4Completed1
DB10788Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)Not AvailableCompleted1
DB10790Bordetella pertussis fimbriae 2/3 antigenNot AvailableCompleted1
DB10789Bordetella pertussis pertactin antigenNot AvailableCompleted1
DB10787Bordetella pertussis toxoid antigen (glutaraldehyde inactivated)Not AvailableCompleted1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)Not AvailableCompleted4
DB10584Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)Not AvailableCompleted3
DB10342Haemophilus influenzae type b capsular polysaccharide meningococcal outer membrane protein conjugate antigenNot AvailableActive Not Recruiting1
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigenNot AvailableActive Not Recruiting1
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigenNot AvailableCompleted1
DB14007Pentetic acidNot AvailableCompleted1
DB10795Poliovirus type 1 antigen (formaldehyde inactivated)Not AvailableCompleted1
DB10796Poliovirus type 2 antigen (formaldehyde inactivated)Not AvailableCompleted1
DB10797Poliovirus type 3 antigen (formaldehyde inactivated)Not AvailableCompleted1