Diphtheria

Also known as: Diphtheria, unspecified / Infection due to Corynebacterium diphtheriae / Corynebacterium diphtheriae infection

DrugDrug NameDrug Description
DB01053BenzylpenicillinBenzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as *Streptococcus pneumoniae*, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (*S. agalactiae*), *S. viridans*, and *Enterococcus faecalis*. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as *Bacillus anthracis*, *Corynebacterium diphtheriae*, and *Erysipelothrix rhusiopathiae*. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by *Neisseria meningitidis* and *Pasteurella*. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium sulfate filtration and precipation.
DB09877Corynebacterium diphtheriae*Corynebacterium diphtheriae* toxin is extracted from the pathogenic actinobacterium *C. diphtheriae* that causes diphtheria. The bacteria culture is grown in a medium and through purification, diphtheria toxin is detoxified with formaldehyde and diafiltered. The vaccine is intramuscularly administered to provide active immunization against diphtheria in infants and children.
DB00199ErythromycinErythromycin is an antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the _macrolide_ group of antibiotics [FDA label]. It was originally discovered in 1952. Erythromycin is widely used for treating a variety of infections, including those caused by gram-positive bacteria, gram-negative bacteria and many other organisms [L5245], [FDA label].
DB09320Procaine benzylpenicillinProcaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Procaine benzylpenicillin is administered by deep intramuscular injection. It is slowly absorbed and hydrolyzed to benzylpenicillin. This drug is used where prolonged exposure to benzylpenicillin at a low concentration is required. This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings. Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many infections.
DrugDrug NameTargetType
DB01053BenzylpenicillinSolute carrier family 22 member 5transporter
DB01053BenzylpenicillinSolute carrier family 15 member 1transporter
DB01053BenzylpenicillinSolute carrier family 15 member 2transporter
DB01053BenzylpenicillinSolute carrier family 22 member 6transporter
DB01053BenzylpenicillinSolute carrier family 22 member 8transporter
DB01053BenzylpenicillinSolute carrier family 22 member 4transporter
DB01053BenzylpenicillinSolute carrier family 22 member 11transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 2B1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 4A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 3A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 1B1transporter
DB01053BenzylpenicillinPenicillin-binding protein 3target
DB01053BenzylpenicillinBeta-lactamase TEMtarget
DB01053BenzylpenicillinSolute carrier family 22 member 8target
DB01053BenzylpenicillinSolute carrier family 15 member 1target
DB01053BenzylpenicillinSolute carrier family 15 member 2target
DB00199Erythromycin23S rRNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinMultidrug resistance protein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB00199ErythromycinBacterial 50S Ribosomal Subunittarget
DB00199ErythromycinCanalicular multispecific organic anion transporter 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DrugDrug NamePhaseStatusCount
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)1 / 2Active Not Recruiting1
DB10788Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)2Completed1
DB10790Bordetella pertussis fimbriae 2/3 antigen2Completed1
DB10789Bordetella pertussis pertactin antigen2Completed1
DB10787Bordetella pertussis toxoid antigen (glutaraldehyde inactivated)2Completed1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)2Completed2
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)2Recruiting1
DB10584Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)2Completed1
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen2Completed1
DB11627Hepatitis B Vaccine (Recombinant)2Completed2
DB13890Meningococcal polysaccharide vaccine group C2Completed1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen2Completed1
DB10795Poliovirus type 1 antigen (formaldehyde inactivated)2Completed2
DB10796Poliovirus type 2 antigen (formaldehyde inactivated)2Completed1
DB10797Poliovirus type 3 antigen (formaldehyde inactivated)2Completed1
DB10276Rotavirus Vaccine2Completed1
DB06361rsPSMA Vaccine2Completed1
DB10788Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)3Completed5
DB10790Bordetella pertussis fimbriae 2/3 antigen3Completed3
DB10789Bordetella pertussis pertactin antigen3Completed3
DB10787Bordetella pertussis toxoid antigen (glutaraldehyde inactivated)3Completed3
DB11121Chloroxylenol3Completed1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)3Completed16
DB10584Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)3Completed6
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen3Active Not Recruiting1
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen3Completed4
DB10990Haemophilus influenzae type b strain 20752 capsular polysaccharide tetanus toxoid conjugate antigen3Completed11
DB11627Hepatitis B Vaccine (Recombinant)3Completed3
DB10300Human papillomavirus type 11 L1 capsid protein antigen3Completed1
DB14618INFLUENZA A VIRUS A/BRISBANE/59/2007(H1N1) HEMAGGLUTININ ANTIGEN (FORMALDEHYDE INACTIVATED)3Completed1
DB14617INFLUENZA A VIRUS A/URUGUAY/716/2007(H3N2) HEMAGGLUTININ ANTIGEN (FORMALDEHYDE INACTIVATED)3Completed1
DB14385Influenza b virus b/brisbane/60/2008 hemagglutinin antigen (formaldehyde inactivated)3Completed1
DB10315Measles virus strain enders' attenuated edmonston live antigen3Completed1
DB13890Meningococcal polysaccharide vaccine group C3Completed1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen3Completed1
DB10795Poliovirus type 1 antigen (formaldehyde inactivated)3Completed5
DB10796Poliovirus type 2 antigen (formaldehyde inactivated)3Completed3
DB10797Poliovirus type 3 antigen (formaldehyde inactivated)3Completed3
DB10276Rotavirus Vaccine3Completed2
DB10286Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen3Completed2
DB10318Varicella Zoster Vaccine (Live/Attenuated)3Completed1
DB09145Water3Completed1
DB10788Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)4Completed1
DB10790Bordetella pertussis fimbriae 2/3 antigen4Completed1
DB10789Bordetella pertussis pertactin antigen4Completed1
DB10787Bordetella pertussis toxoid antigen (glutaraldehyde inactivated)4Completed1
DB01114Chlorphenamine4Completed1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)4Completed10
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)4Terminated1
DB00318Codeine4Completed1
DB10584Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)4Completed3
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen4Completed1
DB10989Hepatitis A Vaccine4Terminated1
DB10061Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine4Completed1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen4Completed2
DB15274Pertussis vaccine4Completed1
DB10795Poliovirus type 1 antigen (formaldehyde inactivated)4Completed1
DB10796Poliovirus type 2 antigen (formaldehyde inactivated)4Completed1
DB10797Poliovirus type 3 antigen (formaldehyde inactivated)4Completed1
DB10319Streptococcus pneumoniae type 1 capsular polysaccharide antigen4Completed1
DB10293Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen4Completed1
DB00656Trazodone4Completed1
DB10788Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)Not AvailableCompleted1
DB10790Bordetella pertussis fimbriae 2/3 antigenNot AvailableCompleted1
DB10789Bordetella pertussis pertactin antigenNot AvailableCompleted1
DB10787Bordetella pertussis toxoid antigen (glutaraldehyde inactivated)Not AvailableCompleted1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)Not AvailableCompleted4
DB10584Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)Not AvailableCompleted3
DB10342Haemophilus influenzae type b capsular polysaccharide meningococcal outer membrane protein conjugate antigenNot AvailableActive Not Recruiting1
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigenNot AvailableActive Not Recruiting1
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigenNot AvailableCompleted1
DB14007Pentetic acidNot AvailableCompleted1
DB10795Poliovirus type 1 antigen (formaldehyde inactivated)Not AvailableCompleted1
DB10796Poliovirus type 2 antigen (formaldehyde inactivated)Not AvailableCompleted1
DB10797Poliovirus type 3 antigen (formaldehyde inactivated)Not AvailableCompleted1