Meningitis

Also known as: Meningitis NOS / Meningitis due to other and unspecified causes / Meningitis of unspecified cause / Meningitis, unspecified

DrugDrug NameDrug Description
DB01053BenzylpenicillinBenzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as *Streptococcus pneumoniae*, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (*S. agalactiae*), *S. viridans*, and *Enterococcus faecalis*. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as *Bacillus anthracis*, *Corynebacterium diphtheriae*, and *Erysipelothrix rhusiopathiae*. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by *Neisseria meningitidis* and *Pasteurella*. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
DB01112CefuroximeBroad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
DB00916MetronidazoleA nitroimidazole used to treat amebiasis; vaginitis; trichomonas infections; giardiasis; anaerobic bacteria; and treponemal infections. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
DrugDrug NameTargetType
DB01053BenzylpenicillinSolute carrier family 22 member 5transporter
DB01053BenzylpenicillinSolute carrier family 15 member 1transporter
DB01053BenzylpenicillinSolute carrier family 15 member 2transporter
DB01053BenzylpenicillinSolute carrier family 22 member 6transporter
DB01053BenzylpenicillinSolute carrier family 22 member 8transporter
DB01053BenzylpenicillinSolute carrier family 22 member 4transporter
DB01053BenzylpenicillinSolute carrier family 22 member 11transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 2B1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 4A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 3A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 1B1transporter
DB01053BenzylpenicillinPenicillin-binding protein 3target
DB01053BenzylpenicillinBeta-lactamase TEMtarget
DB01053BenzylpenicillinSolute carrier family 22 member 8target
DB01053BenzylpenicillinSolute carrier family 15 member 1target
DB01053BenzylpenicillinSolute carrier family 15 member 2target
DB01112CefuroximePenicillin-binding protein 1Atarget
DB01112CefuroximeSolute carrier family 15 member 1transporter
DB01112CefuroximeSolute carrier family 15 member 2transporter
DB00916MetronidazoleIron hydrogenase 1target
DB00916MetronidazoleDNAtarget
DB00916MetronidazoleOxygen-insensitive NADPH nitroreductasetarget
DB00916MetronidazoleCytochrome P450 2C9enzyme
DB00916MetronidazoleCytochrome P450 3A4enzyme
DB00916MetronidazoleCytochrome P450 2C8enzyme
DB00916MetronidazoleLanosterol 14-alpha demethylasetarget
DB00916MetronidazoleUDP-glucuronosyltransferase 1-1enzyme
DrugDrug NamePhaseStatusCount
DB06590Ceftaroline fosamil1Recruiting1
DB00080Daptomycin1Terminated1
DB06211Doripenem1Terminated1
DB00441Gemcitabine1Terminated1
DB00760Meropenem1 / 2Completed1
DB00681Amphotericin B2Recruiting1
DB10788Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)2Completed1
DB10790Bordetella pertussis fimbriae 2/3 antigen2Completed1
DB10789Bordetella pertussis pertactin antigen2Completed1
DB10787Bordetella pertussis toxoid antigen (glutaraldehyde inactivated)2Completed1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)2Completed2
DB10584Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)2Completed1
DB00196Fluconazole2Recruiting1
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen2Completed1
DB10990Haemophilus influenzae type b strain 20752 capsular polysaccharide tetanus toxoid conjugate antigen2Completed1
DB11627Hepatitis B Vaccine (Recombinant)2Completed1
DB10300Human papillomavirus type 11 L1 capsid protein antigen2Completed1
DB10061Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine2Completed1
DB13889Meningococcal polysaccharide vaccine group A2Completed1
DB13890Meningococcal polysaccharide vaccine group C2Completed1
DB13887Meningococcal polysaccharide vaccine group W-1352Completed1
DB13888Meningococcal polysaccharide vaccine group Y2Completed1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen2Completed10
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen2Terminated1
DB10795Poliovirus type 1 antigen (formaldehyde inactivated)2Completed1
DB10796Poliovirus type 2 antigen (formaldehyde inactivated)2Completed1
DB10797Poliovirus type 3 antigen (formaldehyde inactivated)2Completed1
DB10303Rotavirus Vaccine2Completed1
DB09153Sodium chloride2Completed1
DB10286Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen2Completed1
DB00675Tamoxifen2Recruiting1
DB10318Varicella Zoster Vaccine (Live/Attenuated)2Completed1
DB00169Cholecalciferol2 / 3Completed1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)3Completed1
DB10300Human papillomavirus type 11 L1 capsid protein antigen3Completed1
DB10061Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine3Completed2
DB13889Meningococcal polysaccharide vaccine group A3Completed1
DB13890Meningococcal polysaccharide vaccine group C3Completed1
DB13887Meningococcal polysaccharide vaccine group W-1353Completed1
DB13888Meningococcal polysaccharide vaccine group Y3Completed1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen3Completed6
DB00512Vancomycin3Completed1
DB10318Varicella Zoster Vaccine (Live/Attenuated)3Completed1
DB11248Zinc gluconate3Completed1
DB10788Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)4Completed1
DB10790Bordetella pertussis fimbriae 2/3 antigen4Completed1
DB10789Bordetella pertussis pertactin antigen4Completed1
DB10787Bordetella pertussis toxoid antigen (glutaraldehyde inactivated)4Completed1
DB01212Ceftriaxone4Completed1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)4Completed2
DB10584Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)4Completed1
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen4Completed1
DB10061Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine4Completed2
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen4Active Not Recruiting1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen4Completed6
DB10783Neisseria meningitidis serogroup b nhba fusion protein antigen4Completed1
DB10795Poliovirus type 1 antigen (formaldehyde inactivated)4Completed1
DB10796Poliovirus type 2 antigen (formaldehyde inactivated)4Completed1
DB10797Poliovirus type 3 antigen (formaldehyde inactivated)4Completed1
DB10286Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen4Completed1
DB00080DaptomycinNot AvailableTerminated1
DB00196FluconazoleNot AvailableCompleted1
DB00281LidocaineNot AvailableTerminated1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigenNot AvailableCompleted3