Hepatoblastomas

Also known as: Hepatoblastoma / Hepatoblastoma NOS

DrugDrug NameDrug Description
DB00515CisplatinCisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
DB00541VincristineVincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
DrugDrug NameTargetType
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinMultidrug resistance protein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB00541VincristineTubulin beta chaintarget
DB00541VincristineCytochrome P450 3A4enzyme
DB00541VincristineCytochrome P450 3A5enzyme
DB00541VincristineCytochrome P450 3A7enzyme
DB00541VincristineMultidrug resistance protein 1transporter
DB00541VincristineCanalicular multispecific organic anion transporter 2transporter
DB00541VincristineSolute carrier family 22 member 3transporter
DB00541VincristineMultidrug resistance-associated protein 1transporter
DB00541VincristineMultidrug resistance-associated protein 7transporter
DB00541VincristineCanalicular multispecific organic anion transporter 1transporter
DB00541VincristineBile salt export pumptransporter
DB00541VincristineATP-binding cassette sub-family G member 2transporter
DB00541VincristineTubulin alpha-4A chaintarget
DB00541VincristineRalA-binding protein 1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B3transporter
DrugDrug NamePhaseStatusCount
DB00531Cyclophosphamide1Recruiting1
DB00641Simvastatin1Recruiting1
DB00877Sirolimus1Active Not Recruiting1
DB01030Topotecan1Recruiting1
DB09143Sonidegib1 / 2Completed1
DB05220Alisertib2Completed1
DB08875Cabozantinib2Recruiting1
DB05036Grn163l2Withdrawn1
DB08881Vemurafenib2Recruiting1
DB00958Carboplatin2 / 3Recruiting1
DB00515Cisplatin2 / 3Recruiting1
DB00997Doxorubicin2 / 3Recruiting1
DB00773Etoposide2 / 3Recruiting1
DB00544Fluorouracil2 / 3Recruiting1
DB00441Gemcitabine2 / 3Recruiting1
DB00762Irinotecan2 / 3Recruiting1
DB12117Mitometh2 / 3Recruiting1
DB00526Oxaliplatin2 / 3Recruiting1
DB00398Sorafenib2 / 3Recruiting1
DB00541Vincristine2 / 3Recruiting1
DB00958Carboplatin3Recruiting1
DB00515Cisplatin3Recruiting1
DB00997Doxorubicin3Recruiting1
DB00773Etoposide3Recruiting1
DB00441Gemcitabine3Recruiting1
DB00762Irinotecan3Recruiting1
DB00526Oxaliplatin3Recruiting1
DB00398Sorafenib3Recruiting1
DB00541Vincristine3Recruiting1
DB00020Sargramostim4Not Yet Recruiting1
DB01008BusulfanNot AvailableRecruiting1
DB00958CarboplatinNot AvailableRecruiting1
DB09110Coenzyme MNot AvailableRecruiting1
DB00773EtoposideNot AvailableRecruiting1
DB01181IfosfamideNot AvailableRecruiting1
DB01042MelphalanNot AvailableRecruiting1
DB01229PaclitaxelNot AvailableRecruiting1
DB04572ThiotepaNot AvailableRecruiting1
DB01586Ursodeoxycholic acidNot AvailableRecruiting1