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Identification
NameLorazepam
Accession NumberDB00186  (APRD00116)
TypeSmall Molecule
GroupsApproved
DescriptionA benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. [PubChem]
Structure
Thumb
Synonyms
(±)-Lorazepam
Ativan
Lormetazepam
Methyllorazepam
N-Methyllorazepam
O-Chlorooxazepam
O-Chloroxazepam
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AtivanInjection4 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
AtivanTablet1 mg/1OralSTAT Rx USA LLC2010-03-16Not applicableUs
AtivanTablet2 mgOralPfizer Canada Inc1994-12-31Not applicableCanada
AtivanTablet1 mg/1OralValeant Pharmaceuticals North America LLC2013-05-01Not applicableUs
AtivanTablet1 mg/1OralCardinal Health2010-03-162016-10-13Us
AtivanInjection4 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
AtivanTablet.5 mg/1OralSTAT Rx USA LLC2010-03-16Not applicableUs
AtivanTablet2 mg/1OralValeant Pharmaceuticals North America LLC2013-05-01Not applicableUs
AtivanTablet1 mgOralPfizer Canada Inc1994-12-31Not applicableCanada
AtivanTablet1 mgSublingualPfizer Canada Inc1994-12-31Not applicableCanada
AtivanTablet1 mg/1OralA S Medication Solutions Llc2013-05-01Not applicableUs
AtivanTablet0.5 mgOralPfizer Canada Inc1994-12-31Not applicableCanada
AtivanInjection2 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
AtivanTablet1 mg/1OralRx Pak Division Of Mc Kesson Corporation2013-05-01Not applicableUs
AtivanTablet2 mgSublingualPfizer Canada Inc1994-12-31Not applicableCanada
AtivanTablet.5 mg/1OralValeant Pharmaceuticals North America LLC2013-05-01Not applicableUs
AtivanTablet1 mg/1OralA S Medication Solutions Llc2010-03-16Not applicableUs
AtivanTablet0.5 mgSublingualPfizer Canada Inc1995-12-31Not applicableCanada
AtivanInjection2 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
Ativan Inj 4mg/mlLiquid4 mgIntramuscular; IntravenousWyeth Ltd.1982-12-311996-09-10Canada
Ativan Injection Liq 4mg/mlSolution4 mgIntramuscular; IntravenousWyeth Canada1994-12-312005-01-19Canada
Ativan Subl Tab 0.5mgTablet0.5 mgSublingualWyeth Ltd.1987-12-311996-09-10Canada
Ativan Subl Tab 1mgTablet1 mgSublingualWyeth Ltd.1982-12-311996-09-10Canada
Ativan Tab 0.5mgTablet.5 mgOralWyeth Ltd.1983-12-311996-09-10Canada
Ativan Tab 1mgTablet1 mgOralWyeth Ltd.1977-12-311996-09-10Canada
Ativan Tab 2mgTablet2 mgOralWyeth Ltd.1977-12-311996-09-10Canada
Dom-lorazepamTablet1 mgOralDominion Pharmacal2002-04-25Not applicableCanada
Dom-lorazepamTablet2 mgOralDominion Pharmacal2002-04-25Not applicableCanada
Dom-lorazepamTablet.5 mgOralDominion Pharmacal2002-04-25Not applicableCanada
LorazepamInjection4 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
LorazepamInjection, solution2 mg/mLIntramuscular; IntravenousBaxter Healthcare Corporation2005-09-232015-12-29Us
LorazepamTablet2.0 mgOralSanis Health Inc2010-06-15Not applicableCanada
LorazepamInjection2 mg/mLIntramuscular; IntravenousREMEDYREPACK INC.2016-02-05Not applicableUs
LorazepamInjection2 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
LorazepamTablet2 mgOralSivem Pharmaceuticals Ulc2015-03-12Not applicableCanada
LorazepamInjection2 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
LorazepamInjection, solution4 mg/mLIntramuscular; IntravenousBaxter Healthcare Corporation2005-09-232015-12-29Us
LorazepamTablet0.5 mgOralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
LorazepamTablet.5 mg/1OralOceanside Pharmaceuticals2013-05-01Not applicableUs
LorazepamInjection2 mg/mLIntramuscular; IntravenousTYA Pharmaceuticals1980-07-25Not applicableUs
LorazepamInjection4 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
LorazepamInjection4 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
LorazepamInjection2 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
LorazepamTablet0.5 mgOralSanis Health Inc2010-06-15Not applicableCanada
LorazepamTablet1 mg/1OralOceanside Pharmaceuticals2013-05-01Not applicableUs
LorazepamInjection2 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
LorazepamInjection2 mg/mLIntramuscular; IntravenousREMEDYREPACK INC.2015-05-19Not applicableUs
LorazepamInjection4 mg/mLIntramuscular; IntravenousWest Ward Pharmaceuticals Corp.1980-07-25Not applicableUs
LorazepamTablet1 mgOralSivem Pharmaceuticals Ulc2015-03-12Not applicableCanada
LorazepamTablet2 mg/1OralOceanside Pharmaceuticals2013-05-01Not applicableUs
LorazepamTablet1.0 mgOralSanis Health Inc2010-06-15Not applicableCanada
Lorazepam Injection USPSolution4 mgIntramuscular; IntravenousHospira Healthcare Corporation2014-06-10Not applicableCanada
Lorazepam Injection USPLiquid4 mgIntramuscular; IntravenousSandoz Canada Incorporated2001-06-06Not applicableCanada
Lorazepam Injection USPSolution2 mgIntramuscular; IntravenousSandoz Canada Incorporated2015-11-12Not applicableCanada
Ntp-lorazepamTablet2.0 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-lorazepamTablet0.5 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-lorazepamTablet1.0 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Nu-loraz Tab 0.5mgTablet.5 mgOralNu Pharm Inc1990-12-312012-09-04Canada
Nu-loraz Tab 1mgTablet1 mgOralNu Pharm Inc1990-12-312012-09-04Canada
Nu-loraz Tab 2mgTablet2 mgOralNu Pharm Inc1990-12-312012-09-04Canada
PHL-lorazepamTablet1 mgOralPharmel Inc2007-07-30Not applicableCanada
PHL-lorazepamTablet2 mgOralPharmel Inc2007-07-30Not applicableCanada
PHL-lorazepamTablet0.5 mgOralPharmel Inc2007-07-30Not applicableCanada
PMS-lorazepam Tab 0.5mgTablet0.5 mgOralPharmascience Inc1988-12-31Not applicableCanada
PMS-lorazepam Tab 1mgTablet1 mgOralPharmascience Inc1988-12-31Not applicableCanada
PMS-lorazepam Tab 2mgTablet2 mgOralPharmascience Inc1988-12-31Not applicableCanada
Pro-lorazepam Tab 0.5mgTablet0.5 mgOralPro Doc Limitee1986-12-31Not applicableCanada
Pro-lorazepam Tab 1.0mgTablet1 mgOralPro Doc Limitee1986-12-31Not applicableCanada
Pro-lorazepam Tab 2mgTablet2 mgOralPro Doc Limitee1986-12-31Not applicableCanada
Riva-lorazepam 0.5 Mg TabletsTablet0.5 mgOralLaboratoire Riva Inc1999-08-262003-07-28Canada
Riva-lorazepam 1 Mg TabletsTablet1 mgOralLaboratoire Riva Inc1999-08-262003-07-28Canada
Riva-lorazepam 2mg TabletsTablet2 mgOralLaboratoire Riva Inc1999-08-262003-07-28Canada
Teva-lorazepamTablet1 mgOralTeva Canada Limited1985-12-31Not applicableCanada
Teva-lorazepamTablet2 mgOralTeva Canada Limited1985-12-31Not applicableCanada
Teva-lorazepamTablet0.5 mgOralTeva Canada Limited1987-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-lorazepam SublingualTablet0.5 mgSublingualApotex Inc2013-10-16Not applicableCanada
Apo-lorazepam SublingualTablet1 mgSublingualApotex Inc2013-10-16Not applicableCanada
Apo-lorazepam SublingualTablet2 mgSublingualApotex Inc2013-10-16Not applicableCanada
Apo-lorazepam Tab 0.5mgTablet0.5 mgOralApotex Inc1985-12-31Not applicableCanada
Apo-lorazepam Tab 1mgTablet1 mgOralApotex Inc1985-12-31Not applicableCanada
Apo-lorazepam Tab 2mgTablet2 mgOralApotex Inc1985-12-31Not applicableCanada
LorazepamTablet.5 mg/1OralExcellium Pharmaceutical Inc.2007-10-01Not applicableUs
LorazepamTablet1 mg/1OralRed Pharm Drug Inc.1988-04-15Not applicableUs
LorazepamTablet1 mg/1OralActavis Pharma, Inc.1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralPreferred Pharmaceuticals, Inc2012-03-29Not applicableUs
LorazepamTablet2 mg/1OralREMEDYREPACK INC.2012-08-202016-10-15Us
LorazepamTablet1 mg/1OralBlenheim Pharmacal, Inc.2012-09-04Not applicableUs
LorazepamTablet1 mg/1OralKAISER FOUNDATION HOSPITALS2015-09-15Not applicableUs
LorazepamTablet1 mg/1OralCardinal Health2007-01-04Not applicableUs
LorazepamTablet1 mg/1OralLake Erie Medical DBA Quality Care Products LLC2007-01-04Not applicableUs
LorazepamTablet2 mg/1OralPd Rx Pharmaceuticals, Inc.1991-10-31Not applicableUs
LorazepamTablet.5 mg/1OralRanbaxy Pharmaceuticals Inc.2001-12-11Not applicableUs
LorazepamTablet1 mg/1OralA S Medication Solutions Llc1991-10-31Not applicableUs
LorazepamTablet.5 mg/1OralLeading Pharma, Llc2007-10-01Not applicableUs
LorazepamTablet2 mg/1OralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation1999-07-28Not applicableUs
LorazepamTablet2 mg/1OralRx Pak Division Of Mc Kesson Corporation2009-10-09Not applicableUs
LorazepamInjection, solution4 mg/mLIntramuscular; IntravenousHospira, Inc.2011-05-26Not applicableUs
LorazepamTablet2 mg/1OralAphena Pharma Solutions Tennessee, Llc2013-03-05Not applicableUs
LorazepamTablet2 mg/1OralUnit Dose Services2007-01-08Not applicableUs
LorazepamTablet2 mg/1OralSandoz Inc2007-01-08Not applicableUs
LorazepamTablet.5 mg/1OralTeva Pharmaceuticals USA Inc2007-02-012016-03-11Us
LorazepamTablet1 mg/1OralAmerican Health Packaging2008-05-012015-12-29Us
LorazepamTablet1 mg/1OralPhysicians Total Care, Inc.1993-07-23Not applicableUs
LorazepamTablet1 mg/1OralRebel Distributors Corp1988-04-15Not applicableUs
LorazepamTablet.5 mg/1OralMajor Pharmaceuticals2009-10-09Not applicableUs
LorazepamTablet2 mg/1OralCardinal Health2006-05-10Not applicableUs
LorazepamTablet2 mg/1OralSTAT Rx USA LLC1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-05-10Not applicableUs
LorazepamTablet.5 mg/1OralAidarex Pharmaceuticals LLC2007-10-01Not applicableUs
LorazepamTablet.5 mg/1OralTYA Pharmaceuticals2001-12-11Not applicableUs
LorazepamTablet.5 mg/1OralAphena Pharma Solutions Tennessee, Llc1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralSandoz Inc2007-01-04Not applicableUs
LorazepamTablet.5 mg/1OralMc Kesson Contract Packaging2012-08-28Not applicableUs
LorazepamTablet2 mg/1OralA S Medication Solutions Llc1991-10-31Not applicableUs
LorazepamTablet.5 mg/1OralSTAT Rx USA LLC1991-10-31Not applicableUs
LorazepamTablet2 mg/1OralActavis Elizabeth LLC2007-01-082016-10-13Us
LorazepamConcentrate2 mg/mLOralAmneal Pharmaceuticals of New York, LLC2010-02-01Not applicableUs
LorazepamTablet1 mg/1OralCardinal Health2010-12-17Not applicableUs
LorazepamTablet1 mg/1OralRebel Distributors Corp2009-10-09Not applicableUs
LorazepamTablet1 mg/1OralProficient Rx LP2007-01-04Not applicableUs
LorazepamTablet.5 mg/1Oralbryant ranch prepack1991-10-31Not applicableUs
LorazepamTablet.5 mg/1OralA S Medication Solutions Llc1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralQualitest Pharmaceuticals2006-05-102018-07-19Us
LorazepamTablet2 mg/1OralREMEDYREPACK INC.2016-10-05Not applicableUs
LorazepamTablet.5 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-07-01Not applicableUs
LorazepamTablet.5 mg/1OralContract Pharmacy Services Pa2011-03-29Not applicableUs
LorazepamInjection, solution2 mg/mLIntramuscular; IntravenousHospira, Inc.1994-05-27Not applicableUs
LorazepamTablet1 mg/1OralPreferred Pharmaceuticals, Inc.2013-08-27Not applicableUs
LorazepamTablet1 mg/1OralNorthwind Pharmaceuticals2014-06-01Not applicableUs
LorazepamTablet.5 mg/1OralMajor Pharmaceuticals2010-03-24Not applicableUs
LorazepamTablet.5 mg/1OralKAISER FOUNDATION HOSPITALS2013-03-11Not applicableUs
LorazepamTablet2 mg/1OralAmerican Health Packaging2013-06-192015-12-29Us
LorazepamTablet1 mg/1OralCardinal Health2006-05-10Not applicableUs
LorazepamTablet2 mg/1OralAidarex Pharmaceuticals LLC2007-10-01Not applicableUs
LorazepamTablet2 mg/1OralREMEDYREPACK INC.2014-04-18Not applicableUs
LorazepamTablet.5 mg/1OralProficient Rx LP2006-12-27Not applicableUs
LorazepamTablet1 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-01-31Not applicableUs
LorazepamTablet1 mg/1OralExcellium Pharmaceutical Inc.2007-10-01Not applicableUs
LorazepamTablet1 mg/1OralRed Pharm Drug Inc.1991-10-31Not applicableUs
LorazepamTablet2 mg/1OralActavis Pharma, Inc.1991-10-31Not applicableUs
LorazepamTablet.5 mg/1OralPreferred Pharmaceuticals, Inc2012-03-29Not applicableUs
LorazepamTablet.5 mg/1OralREMEDYREPACK INC.2013-05-132016-10-13Us
LorazepamTablet1 mg/1OralBlenheim Pharmacal, Inc.2011-01-12Not applicableUs
LorazepamTablet.5 mg/1OralKAISER FOUNDATION HOSPITALS2015-11-23Not applicableUs
LorazepamTablet.5 mg/1OralCardinal Health2007-01-03Not applicableUs
LorazepamTablet2 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2007-01-08Not applicableUs
LorazepamTablet.5 mg/1OralREMEDYREPACK INC.2015-05-12Not applicableUs
LorazepamTablet1 mg/1OralRanbaxy Pharmaceuticals Inc.2001-12-11Not applicableUs
LorazepamTablet1 mg/1OralA S Medication Solutions Llc1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralLeading Pharma, Llc2007-10-01Not applicableUs
LorazepamTablet.5 mg/1OralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-09-01Not applicableUs
LorazepamTablet1 mg/1OralDispensing Solutions, Inc.2007-01-04Not applicableUs
LorazepamInjection, solution2 mg/mLIntramuscular; IntravenousHospira, Inc.2011-04-25Not applicableUs
LorazepamTablet.5 mg/1OralAmerican Health Packaging2014-04-01Not applicableUs
LorazepamTablet1 mg/1OralMylan Institutional Inc.2006-12-29Not applicableUs
LorazepamTablet.5 mg/1OralUpsher Smith Laboratories, Inc.2007-01-032016-07-01Us
LorazepamTablet1 mg/1OralTeva Pharmaceuticals USA Inc2007-02-012016-03-11Us
LorazepamTablet2 mg/1OralAmerican Health Packaging2008-05-012015-12-29Us
LorazepamTablet.5 mg/1OralPhysicians Total Care, Inc.1993-06-29Not applicableUs
LorazepamTablet2 mg/1OralRebel Distributors Corp1988-04-15Not applicableUs
LorazepamTablet1 mg/1OralMajor Pharmaceuticals2009-10-09Not applicableUs
LorazepamTablet.5 mg/1OralPd Rx Pharmaceuticals, Inc.1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralSTAT Rx USA LLC1991-10-31Not applicableUs
LorazepamTablet2 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-05-10Not applicableUs
LorazepamTablet.5 mg/1OralRed Pharm Drug, Inc.2000-01-01Not applicableUs
LorazepamTablet.5 mg/1OralDirectrx2016-02-18Not applicableUs
LorazepamTablet2 mg/1Oralbryant ranch prepack1991-10-31Not applicableUs
LorazepamConcentrate2 mg/mLOralHi Tech Pharmacal Co., Inc.2012-01-30Not applicableUs
LorazepamTablet2 mg/1OralQualitest Pharmaceuticals2006-05-102018-05-31Us
LorazepamTablet1 mg/1OralTYA Pharmaceuticals2001-12-11Not applicableUs
LorazepamTablet1 mg/1OralAphena Pharma Solutions Tennessee, Llc1991-10-31Not applicableUs
LorazepamTablet2 mg/1OralSandoz Inc2007-01-08Not applicableUs
LorazepamTablet1 mg/1OralMc Kesson Contract Packaging2012-09-07Not applicableUs
LorazepamTablet.5 mg/1OralA S Medication Solutions Llc1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralSTAT Rx USA LLC1991-10-31Not applicableUs
LorazepamTablet.5 mg/1OralMylan Pharmaceuticals Inc.2006-12-27Not applicableUs
LorazepamTablet.5 mg/1OralAvera Mc Kennan Hospital2015-05-01Not applicableUs
LorazepamTablet2 mg/1OralCardinal Health2010-12-17Not applicableUs
LorazepamTablet2 mg/1OralRebel Distributors Corp2009-10-09Not applicableUs
LorazepamTablet.5 mg/1OralKAISER FOUNDATION HOSPITALS2014-04-28Not applicableUs
LorazepamTablet1 mg/1OralCardinal Health2010-09-01Not applicableUs
LorazepamTablet.5 mg/1OralAidarex Pharmaceuticals LLC2007-10-01Not applicableUs
LorazepamTablet.5 mg/1OralREMEDYREPACK INC.2014-05-07Not applicableUs
LorazepamTablet1 mg/1OralProficient Rx LP2006-12-27Not applicableUs
LorazepamTablet2 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-01-31Not applicableUs
LorazepamTablet1 mg/1OralREMEDYREPACK INC.2016-10-05Not applicableUs
LorazepamTablet1 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-07-01Not applicableUs
LorazepamTablet1 mg/1OralContract Pharmacy Services Pa2011-03-29Not applicableUs
LorazepamInjection, solution4 mg/mLIntramuscular; IntravenousHospira, Inc.1994-05-27Not applicableUs
LorazepamTablet.5 mg/1OralPreferred Pharmaceuticals Inc.2015-08-27Not applicableUs
LorazepamTablet1 mg/1OralREMEDYREPACK INC.2013-02-252016-10-13Us
LorazepamTablet1 mg/1OralMajor Pharmaceuticals2010-03-24Not applicableUs
LorazepamTablet2 mg/1OralExcellium Pharmaceutical Inc.2007-10-01Not applicableUs
LorazepamTablet.5 mg/1OralRed Pharm Inc.2010-05-18Not applicableUs
LorazepamTablet.5 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-27Not applicableUs
LorazepamTablet1 mg/1OralPreferred Pharmaceuticals, Inc.2015-04-16Not applicableUs
LorazepamTablet2 mg/1OralREMEDYREPACK INC.2013-05-082016-10-13Us
LorazepamTablet1 mg/1OralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
LorazepamTablet.5 mg/1OralActavis Elizabeth LLC2007-01-032016-10-13Us
LorazepamTablet1 mg/1OralCardinal Health2007-01-04Not applicableUs
LorazepamTablet1 mg/1OralLake Erie Medical DBA Quality Care Products LLC2013-03-05Not applicableUs
LorazepamTablet1 mg/1OralREMEDYREPACK INC.2015-06-23Not applicableUs
LorazepamTablet2 mg/1OralRanbaxy Pharmaceuticals Inc.2001-12-11Not applicableUs
LorazepamTablet1 mg/1OralA S Medication Solutions Llc2006-05-10Not applicableUs
LorazepamTablet2 mg/1OralLeading Pharma, Llc2007-10-01Not applicableUs
LorazepamTablet1 mg/1OralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-09-01Not applicableUs
LorazepamTablet.5 mg/1OralDispensing Solutions, Inc.2007-01-03Not applicableUs
LorazepamInjection, solution2 mg/mLIntramuscular; IntravenousHospira, Inc.1994-05-27Not applicableUs
LorazepamTablet1 mg/1OralAmerican Health Packaging2014-04-01Not applicableUs
LorazepamTablet2 mg/1OralMylan Institutional Inc.2006-12-28Not applicableUs
LorazepamTablet1 mg/1OralUpsher Smith Laboratories, Inc.2007-01-042016-07-01Us
LorazepamTablet2 mg/1OralTeva Pharmaceuticals USA Inc2007-02-012016-03-11Us
LorazepamTablet.5 mg/1OralAmerican Health Packaging2013-06-192015-12-29Us
LorazepamInjection, solution2 mg/mLIntramuscular; IntravenousPhysicians Total Care, Inc.2007-01-10Not applicableUs
LorazepamTablet.5 mg/1OralREMEDYREPACK INC.2013-05-212016-10-26Us
LorazepamTablet2 mg/1OralMajor Pharmaceuticals2009-10-09Not applicableUs
LorazepamTablet1 mg/1OralPd Rx Pharmaceuticals, Inc.1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralPd Rx Pharmaceuticals, Inc.1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralREMEDYREPACK INC.2016-05-27Not applicableUs
LorazepamTablet.5 mg/1OralSandoz Inc2007-01-03Not applicableUs
LorazepamTablet2 mg/1OralMc Kesson Contract Packaging2012-10-18Not applicableUs
LorazepamTablet1 mg/1OralA S Medication Solutions Llc1991-10-31Not applicableUs
LorazepamInjection2 mg/mLIntramuscularAkorn, Inc.1980-07-01Not applicableUs
LorazepamTablet1 mg/1OralMylan Pharmaceuticals Inc.2006-12-27Not applicableUs
LorazepamSolution, concentrate2 mg/mLOralWest Ward Pharmaceuticals Corp.1991-06-28Not applicableUs
LorazepamTablet1 mg/1OralCardinal Health2010-03-24Not applicableUs
LorazepamTablet.5 mg/1OralRebel Distributors Corp2009-10-09Not applicableUs
LorazepamTablet1 mg/1OralREMEDYREPACK INC.2016-03-04Not applicableUs
LorazepamTablet.5 mg/1OralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation1999-07-28Not applicableUs
LorazepamTablet.5 mg/1OralUnit Dose Services2007-01-03Not applicableUs
LorazepamTablet1 mg/1OralAidarex Pharmaceuticals LLC2007-10-01Not applicableUs
LorazepamTablet.5 mg/1OralRx Pak Division Of Mc Kesson Corporation2009-10-09Not applicableUs
LorazepamTablet.5 mg/1OralAphena Pharma Solutions Tennessee, Llc2013-03-05Not applicableUs
LorazepamTablet2 mg/1OralContract Pharmacy Services Pa2011-03-29Not applicableUs
LorazepamTablet.5 mg/1OralActavis Pharma, Inc.1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralPreferred Pharmaceuticals, Inc.2014-02-05Not applicableUs
LorazepamTablet.5 mg/1OralREMEDYREPACK INC.2012-08-202016-10-15Us
LorazepamTablet2 mg/1OralMajor Pharmaceuticals2010-03-24Not applicableUs
LorazepamTablet1 mg/1OralKAISER FOUNDATION HOSPITALS2014-11-07Not applicableUs
LorazepamTablet.5 mg/1OralCardinal Health2007-01-03Not applicableUs
LorazepamTablet2 mg/1OralRx Change Co.2014-11-12Not applicableUs
LorazepamTablet1 mg/1OralREMEDYREPACK INC.2014-05-23Not applicableUs
LorazepamTablet.5 mg/1OralProficient Rx LP2007-01-03Not applicableUs
LorazepamTablet.5 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-11-17Not applicableUs
LorazepamTablet.5 mg/1OralNu Care Pharmaceuticals, Inc.2007-01-03Not applicableUs
LorazepamTablet2 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-07-01Not applicableUs
LorazepamTablet2 mg/1OralTYA Pharmaceuticals1991-10-31Not applicableUs
LorazepamTablet2 mg/1OralAphena Pharma Solutions Tennessee, Llc1991-10-31Not applicableUs
LorazepamTablet.5 mg/1OralSandoz Inc2007-01-03Not applicableUs
LorazepamTablet1 mg/1OralLife Line Home Care Services, Inc.1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralA S Medication Solutions Llc1991-10-31Not applicableUs
LorazepamTablet1 mg/1OralApotheca, Inc2001-12-11Not applicableUs
LorazepamTablet1 mg/1OralActavis Elizabeth LLC2007-01-042016-10-13Us
LorazepamTablet.5 mg/1OralCardinal Health2010-12-17Not applicableUs
LorazepamTablet1 mg/1OralLake Erie Medical DBA Quality Care Products LLC2001-12-11Not applicableUs
LorazepamTablet.5 mg/1OralREMEDYREPACK INC.2015-10-08Not applicableUs
LorazepamTablet1 mg/1Oralbryant ranch prepack2009-08-06Not applicableUs
LorazepamTablet1 mg/1OralA S Medication Solutions Llc2006-05-10Not applicableUs
LorazepamTablet.5 mg/1OralQualitest Pharmaceuticals2006-05-102020-05-30Us
LorazepamTablet2 mg/1OralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-09-01Not applicableUs
LorazepamTablet2 mg/1OralDispensing Solutions, Inc.2007-01-08Not applicableUs
LorazepamInjection, solution4 mg/mLIntramuscular; IntravenousHospira, Inc.1994-05-27Not applicableUs
LorazepamTablet2 mg/1OralAmerican Health Packaging2014-04-01Not applicableUs
LorazepamTablet.5 mg/1OralMylan Institutional Inc.2004-03-15Not applicableUs
LorazepamTablet2 mg/1OralUpsher Smith Laboratories, Inc.2007-01-082016-07-01Us
LorazepamLiquid2 mg/mLOralPharmaceutical Associates, Inc.2010-11-01Not applicableUs
LorazepamTablet1 mg/1OralAmerican Health Packaging2013-06-192015-12-29Us
LorazepamTablet.5 mg/1OralCardinal Health2006-05-10Not applicableUs
LorazepamTablet1 mg/1OralAidarex Pharmaceuticals LLC2007-10-01Not applicableUs
LorazepamTablet2 mg/1OralREMEDYREPACK INC.2014-03-10Not applicableUs
LorazepamTablet1 mg/1OralDIRECT RX2014-01-01Not applicableUs
LorazepamTablet.5 mg/1OralPd Rx Pharmaceuticals, Inc.1991-10-31Not applicableUs
LorazepamTablet.5 mg/1OralREMEDYREPACK INC.2016-09-23Not applicableUs
LorazepamTablet1 mg/1OralRx Pak Division Of Mc Kesson Corporation2009-10-09Not applicableUs
LorazepamTablet1 mg/1OralAphena Pharma Solutions Tennessee, Llc2013-03-05Not applicableUs
LorazepamTablet1 mg/1OralSandoz Inc2007-01-04Not applicableUs
LorazepamTablet.5 mg/1OralAmerican Health Packaging2008-05-012015-12-29Us
LorazepamTablet2 mg/1OralPhysicians Total Care, Inc.1995-12-20Not applicableUs
LorazepamTablet.5 mg/1OralRebel Distributors Corp1988-04-15Not applicableUs
LorazepamTablet2 mg/1OralMylan Pharmaceuticals Inc.2006-12-27Not applicableUs
LorazepamSolution, concentrate2 mg/mLOralPaddock Laboratories, LLC2009-04-012017-02-28Us
LorazepamTablet.5 mg/1OralCardinal Health2010-03-24Not applicableUs
LorazepamTablet1 mg/1OralRebel Distributors Corp2007-01-04Not applicableUs
LorazepamTablet.5 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-05-10Not applicableUs
LorazepamTablet1 mg/1OralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation1999-07-28Not applicableUs
LorazepamTablet1 mg/1OralUnit Dose Services1991-10-31Not applicableUs
LorazepamInjection2 mg/mLIntramuscular; IntravenousInternational Medication Systems, Limited2012-12-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AlmazinePsyco Remedies
AnxiedinU-Liang
IdalpremNovartis
LorabenzNot Available
LorsilanBelupo
SomagerolNot Available
TemestaWyeth
WypaxWyeth KK
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIO26FZP769L
CAS number846-49-1
WeightAverage: 321.158
Monoisotopic: 320.011932988
Chemical FormulaC15H10Cl2N2O2
InChI KeyDIWRORZWFLOCLC-UHFFFAOYSA-N
InChI
InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
IUPAC Name
7-chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-1,4-benzodiazepin-2-one
SMILES
OC1N=C(C2=CC=CC=C2Cl)C2=C(NC1=O)C=CC(Cl)=C2
Pharmacology
IndicationFor the management of anxiety disorders, and for treatment of status epilepticus.
Structured Indications
PharmacodynamicsLorazepam, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia.
Mechanism of actionLorazepam binds to an allosteric site on GABA-A receptors, which are pentameric ionotropic receptors in the CNS. Binding potentiates the effects of the inhibitory neurotransmitter GABA, which upon binding opens the chloride channel in the receptor, allowing chloride influx and causing hyperpolerization of the neuron.
TargetKindPharmacological actionActionsOrganismUniProt ID
GABA-A receptor (anion channel)Protein groupyes
positive allosteric modulator
Humannot applicabledetails
Translocator proteinProteinunknown
other
HumanP30536 details
Related Articles
AbsorptionReadily absorbed with an absolute bioavailability of 90% when given orally. When intramuscularly administered, lorazepam is completely and rapidly absorbed. It achieves max serum concentration in 3 hours. The max serum concentration of a 4 mg dose is 48 ng/mL.
Volume of distribution

1.3 L/kg. Unbound lorazepam can cross the blood-brain-barrier via passive diffusion.

Protein binding91±2% bound to plasma proteins when given parenterally. When given orally, it is 85% bound to plasma proteins.
Metabolism

Lorazepam is hepatically metabolized and is extensively conjugated to the 3-0-phenolic glucuronide. This is an inactive metabolite and is eliminated mainly by the kidneys.

SubstrateEnzymesProduct
Lorazepam
Not Available
Lorazepam glucuronideDetails
Route of eliminationWhen a single 2 mg oral dose is give to healthy subjects, 88±4% of the administered dose was recovered in urine and 7±2% was recovered in feces. The percent of administered dose recovered in urine as lorazepam glucuronide was 74±4%. Only 0.3% of the dose was recovered as unchanged lorazepam, and the remainder of the radioactivity represented minor metabolites.
Half lifeParenteral administration = 14±5 hours; Oral administration = 2 hours.
Clearance

Total clearance, parenteral administration = 1.1±0.4 mL/min/kg.

ToxicityThe most important clinical adverse event caused by lorazepam is respiratory depression. LD50, mouse, oral = 1850 mg/kg.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Lorazepam is combined with 1,1,1,2 Tetrafluoroethane.Investigational
7-NitroindazoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with 7-Nitroindazole.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Aceprometazine.Approved
adipiplonThe risk or severity of adverse effects can be increased when Lorazepam is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Lorazepam is combined with Alfentanil.Approved, Illicit
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Alprazolam.Approved, Illicit, Investigational
Ambroxol acefyllinateThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Ambroxol acefyllinate.Experimental
AminophyllineThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Aminophylline.Approved
AmisulprideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Amobarbital.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Amperozide.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with Aripiprazole.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Asenapine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Azaperone.Vet Approved
AzelastineLorazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Lorazepam is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Barbital.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Benzocaine.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Lorazepam is combined with Benzyl alcohol.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved
BromazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Bromazepam.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Brotizolam.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Bupivacaine.Approved, Investigational
BuprenorphineLorazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Lorazepam is combined with Buspirone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butabarbital.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butethal.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butorphanol.Approved, Illicit, Vet Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Lorazepam is combined with Carfentanil.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlordiazepoxide.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlormezanone.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chloroprocaine.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorpromazine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorzoxazone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cinchocaine.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Lorazepam is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clorazepate.Approved, Illicit
ClozapineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clozapine.Approved
CocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Codeine.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cyclobenzaprine.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dapiprazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dapoxetine.Investigational
deramciclaneThe risk or severity of adverse effects can be increased when Lorazepam is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Desflurane.Approved
DesipramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dexmedetomidine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dezocine.Approved
DiazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Diazepam.Approved, Illicit, Vet Approved
DifenoxinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dihydrocodeine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Diphenhydramine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Diphenoxylate.Approved, Illicit
DoramectinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Lorazepam is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Drotebanol.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dyclonine.Approved
DyphyllineThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Dyphylline.Approved
EcgonineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Lorazepam is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Lorazepam is combined with Efavirenz.Approved, Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Enflurane.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Lorazepam is combined with Entacapone.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Lorazepam is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Estazolam.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Eszopiclone.Approved
EthanolLorazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethchlorvynol.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etomidate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etorphine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Flibanserin.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Flunitrazepam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fluphenazine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Flurazepam.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fluticasone Propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Lorazepam.Approved, Investigational
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Lorazepam.Approved
FospropofolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fospropofol.Approved, Illicit
GabapentinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Gabapentin.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Lorazepam is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Lorazepam is combined with Gamma Hydroxybutyric Acid.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Lorazepam is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Glutethimide.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Halazepam.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Halothane.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Heroin.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Hexobarbital.Approved
HyaluronidaseThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Hyaluronidase.Approved, Investigational
HydrocodoneLorazepam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Hydromorphone.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Indalpine.Investigational, Withdrawn
IsofluraneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Isoflurane.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ketamine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ketobemidone.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levobupivacaine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levomethadyl Acetate.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levorphanol.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lidocaine.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lofentanil.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Loratadine.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Lorazepam.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Lorazepam is combined with Lu AA21004.Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Medetomidine.Vet Approved
MefloquineThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Mefloquine.Approved
MelatoninThe risk or severity of adverse effects can be increased when Lorazepam is combined with Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Mepivacaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Meprobamate.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Mesoridazine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Metaxalone.Approved
MethadoneLorazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methadyl Acetate.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methohexital.Approved
MethotrimeprazineLorazepam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methoxyflurane.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methylphenobarbital.Approved
MetyrosineLorazepam may increase the sedative activities of Metyrosine.Approved
MianserinThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Mianserin.Approved
MidazolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Midazolam.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Lorazepam is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved, Investigational
MirtazapineLorazepam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Molindone.Approved
MorphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Morphine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nalbuphine.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nitrazepam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nitrous oxide.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Lorazepam.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Lorazepam is combined with Opium.Approved, Illicit
OrlistatThe serum concentration of Lorazepam can be decreased when it is combined with Orlistat.Approved, Investigational
OrphenadrineLorazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Lorazepam is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxazepam.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxybuprocaine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxymorphone.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Paliperidone.Approved
ParaldehydeLorazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Paroxetine.Approved, Investigational
PentazocineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pentazocine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved
PerazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Lorazepam is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Perphenazine.Approved
PethidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pethidine.Approved
PhenobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Phenoxyethanol.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Lorazepam.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pimozide.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pomalidomide.Approved
PramipexoleLorazepam may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pregabalin.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Prilocaine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Lorazepam can be increased when it is combined with Probenecid.Approved
ProcaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Procaine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Prochlorperazine.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Promethazine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Proparacaine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Propofol.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when Lorazepam is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Quetiapine.Approved
RacloprideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ramelteon.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Lorazepam is combined with Remifentanil.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Remoxipride.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Reserpine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Risperidone.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Romifidine.Vet Approved
RopiniroleLorazepam may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ropivacaine.Approved
RotigotineLorazepam may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Lorazepam.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Lorazepam is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Lorazepam is combined with Sage 547.Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Secobarbital.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with Sertindole.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Sevoflurane.Approved, Vet Approved
Sodium oxybateLorazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.Approved
StiripentolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Lorazepam is combined with Sufentanil.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Sulpiride.Approved
SuvorexantLorazepam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tasimelteon.Approved
TeduglutideThe serum concentration of Lorazepam can be increased when it is combined with Teduglutide.Approved
TemazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Temazepam.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tetrodotoxin.Investigational
ThalidomideLorazepam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Theophylline.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Thiopental.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Thioridazine.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tiapride.Investigational
TiletamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tiletamine.Vet Approved
TizanidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tramadol.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tranylcypromine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Trazodone.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Triazolam.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Trifluoperazine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Triflupromazine.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Triprolidine.Approved
Uc1010The risk or severity of adverse effects can be increased when Lorazepam is combined with Uc1010.Investigational
Valproic AcidThe serum concentration of Lorazepam can be increased when it is combined with Valproic Acid.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Vigabatrin.Approved
VortioxetineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Vortioxetine.Approved
XylazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Xylazine.Vet Approved
YohimbineThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Yohimbine.Approved, Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zaleplon.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zolazepam.Vet Approved
ZolpidemLorazepam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zopiclone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Take with food.
References
Synthesis Reference

Igor Lifshitz, “Process for preparing pure crystalline lorazepam.” U.S. Patent US20010039340, issued November 08, 2001.

US20010039340
General References
  1. Kemper N, Poser W, Poser S: [Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed (author's transl)]. Dtsch Med Wochenschr. 1980 Dec 5;105(49):1707-12. [PubMed:7439058 ]
  2. Lader M: Short-term versus long-term benzodiazepine therapy. Curr Med Res Opin. 1984;8 Suppl 4:120-6. [PubMed:6144459 ]
  3. Maltais F, Laberge F, Laviolette M: A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy. Chest. 1996 May;109(5):1195-8. [PubMed:8625666 ]
  4. Heisterkamp DV, Cohen PJ: The effect of intravenous premedication with lorazepam (ativan), pentobarbitone or diazepam on recall. Br J Anaesth. 1975 Jan;47(1):79-81. [PubMed:238548 ]
  5. Milligan DW, Howard MR, Judd A: Premedication with lorazepam before bone marrow biopsy. J Clin Pathol. 1987 Jun;40(6):696-8. [PubMed:3611398 ]
External Links
ATC CodesN05BA06N05CD06N05BA56
AHFS Codes
  • 28:24.08
PDB EntriesNot Available
FDA labelDownload (540 KB)
MSDSDownload (81.8 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9826
Blood Brain Barrier+0.9641
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.517
P-glycoprotein inhibitor INon-inhibitor0.8866
P-glycoprotein inhibitor IINon-inhibitor0.9167
Renal organic cation transporterNon-inhibitor0.8812
CYP450 2C9 substrateNon-substrate0.7692
CYP450 2D6 substrateNon-substrate0.8685
CYP450 3A4 substrateSubstrate0.5631
CYP450 1A2 substrateInhibitor0.8262
CYP450 2C9 inhibitorNon-inhibitor0.5063
CYP450 2D6 inhibitorNon-inhibitor0.8445
CYP450 2C19 inhibitorInhibitor0.5065
CYP450 3A4 inhibitorNon-inhibitor0.6563
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6407
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.7711
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.8229 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.999
hERG inhibition (predictor II)Non-inhibitor0.8734
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Amneal pharmaceuticals
  • Paddock laboratories inc
  • Pharmaceutical assoc inc
  • Roxane laboratories inc
  • Baxter healthcare corp anesthesia critical care
  • Akorn inc
  • Baxter healthcare corp anesthesia and critical care
  • Bedford laboratories div ben venue laboratories inc
  • Dava pharmaceuticals inc
  • Hospira inc
  • International medication systems ltd
  • Marsam pharmaceuticals llc
  • Taylor pharmaceuticals
  • Watson laboratories inc
  • Bedford laboratories
  • Biovail laboratories inc
  • Quantum pharmics ltd
  • Actavis elizabeth llc
  • American therapeutics inc
  • Excellium pharmaceutical inc
  • Halsey drug co inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Par pharmaceutical inc
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Superpharm corp
  • Usl pharma inc
  • Vintage pharmaceuticals inc
  • Warner chilcott div warner lambert co
Packagers
Dosage forms
FormRouteStrength
InjectionIntramuscular; Intravenous4 mg/mL
TabletOral0.5 mg
TabletOral1 mg
TabletOral2 mg
TabletSublingual0.5 mg
TabletSublingual1 mg
TabletSublingual2 mg
TabletOral.5 mg
ConcentrateOral2 mg/mL
InjectionIntramuscular2 mg/mL
InjectionIntramuscular; Intravenous2 mg/mL
Injection, solutionIntramuscular; Intravenous2 mg/mL
Injection, solutionIntramuscular; Intravenous4 mg/mL
LiquidOral2 mg/mL
Solution, concentrateOral2 mg/mL
TabletOral.5 mg/1
TabletOral1 mg/1
TabletOral1.0 mg
TabletOral2 mg/1
TabletOral2.0 mg
LiquidIntramuscular; Intravenous4 mg
SolutionIntramuscular; Intravenous2 mg
SolutionIntramuscular; Intravenous4 mg
Prices
Unit descriptionCostUnit
LORazepam Intensol 2 mg/ml Concentrate 30ml Bottle44.99USD bottle
Lorazepam powder20.81USD g
Lorazepam 4 mg/ml vial9.59USD ml
Lorazepam 2 mg/ml vial2.5USD ml
Ativan 2 mg tablet2.3USD tablet
Ativan 4 mg/ml vial2.16USD ml
Ativan 1 mg tablet1.96USD tablet
Lorazepam intensol 2 mg/ml1.6USD ml
Lorazepam-ns 60 mg/60 ml bag1.53USD ml
Ativan 0.5 mg tablet1.37USD tablet
Lorazepam-d5w 100 mg/100 ml1.16USD ml
Lorazepam-ns 100 mg/100 ml bag1.16USD ml
Lorazepam 2 mg tablet1.01USD tablet
Ativan 2 mg/ml vial0.9USD ml
Lorazepam 1 mg tablet0.69USD tablet
Lorazepam 0.5 mg tablet0.55USD tablet
Ativan 2 mg Sublingual Tablet0.24USD tablet
Ativan 1 mg Sublingual Tablet0.15USD tablet
Ativan 0.5 mg Sublingual Tablet0.12USD tablet
Apo-Lorazepam 2 mg Tablet0.07USD tablet
Novo-Lorazem 2 mg Tablet0.07USD tablet
Pms-Lorazepam 2 mg Tablet0.07USD tablet
Apo-Lorazepam 1 mg Tablet0.05USD tablet
Novo-Lorazem 1 mg Tablet0.05USD tablet
Pms-Lorazepam 1 mg Tablet0.05USD tablet
Apo-Lorazepam 0.5 mg Tablet0.04USD tablet
Novo-Lorazem 0.5 mg Tablet0.04USD tablet
Pms-Lorazepam 0.5 mg Tablet0.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point192-194British Patent 1,022,642.
water solubility80 mg/LMERCK INDEX (1996)
logP2.39HANSCH,C ET AL. (1995)
logS-3.6ADME Research, USCD
pKa13MERCK INDEX (1996); pK1
Predicted Properties
PropertyValueSource
Water Solubility0.0176 mg/mLALOGPS
logP2.98ALOGPS
logP3.53ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)10.61ChemAxon
pKa (Strongest Basic)-2.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area61.69 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity82.7 m3·mol-1ChemAxon
Polarizability30.33 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-002r-4981000000-a567f7beb26ee18d061cView in MoNA
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzodiazepines
Sub Class1,4-benzodiazepines
Direct Parent1,4-benzodiazepines
Alternative Parents
Substituents
  • 1,4-benzodiazepine
  • Halobenzene
  • Chlorobenzene
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Secondary carboxylic acid amide
  • Lactam
  • Ketimine
  • Carboxamide group
  • Azacycle
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Alkanolamine
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Imine
  • Carbonyl group
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
positive allosteric modulator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Components:
NameUniProt IDDetails
Gamma-aminobutyric acid receptor subunit alpha-1P14867 Details
Gamma-aminobutyric acid receptor subunit alpha-2P47869 Details
Gamma-aminobutyric acid receptor subunit alpha-3P34903 Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169 Details
Gamma-aminobutyric acid receptor subunit alpha-5P31644 Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445 Details
Gamma-aminobutyric acid receptor subunit beta-1P18505 Details
Gamma-aminobutyric acid receptor subunit beta-2P47870 Details
Gamma-aminobutyric acid receptor subunit beta-3P28472 Details
Gamma-aminobutyric acid receptor subunit deltaO14764 Details
Gamma-aminobutyric acid receptor subunit epsilonP78334 Details
Gamma-aminobutyric acid receptor subunit gamma-1Q8N1C3 Details
Gamma-aminobutyric acid receptor subunit gamma-2P18507 Details
Gamma-aminobutyric acid receptor subunit gamma-3Q99928 Details
Gamma-aminobutyric acid receptor subunit piO00591 Details
Gamma-aminobutyric acid receptor subunit thetaQ9UN88 Details
References
  1. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
  2. ChEMBL Compound Report Card [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other
General Function:
Cholesterol binding
Specific Function:
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benz...
Gene Name:
TSPO
Uniprot ID:
P30536
Molecular Weight:
18827.81 Da
References
  1. Venneti S, Lopresti BJ, Wiley CA: The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging. Prog Neurobiol. 2006 Dec;80(6):308-22. Epub 2006 Dec 6. [PubMed:17156911 ]
  2. Park CH, Carboni E, Wood PL, Gee KW: Characterization of peripheral benzodiazepine type sites in a cultured murine BV-2 microglial cell line. Glia. 1996 Jan;16(1):65-70. [PubMed:8787774 ]
  3. Uusi-Oukari M, Korpi ER: Specific alterations in the cerebellar GABA(A) receptors of an alcohol-sensitive ANT rat line. Alcohol Clin Exp Res. 1991 Mar;15(2):241-8. [PubMed:1647706 ]
  4. Miller EI, Wylie FM, Oliver JS: Detection of benzodiazepines in hair using ELISA and LC-ESI-MS-MS. J Anal Toxicol. 2006 Sep;30(7):441-8. [PubMed:16959136 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidatio...
Gene Name:
UGT2B15
Uniprot ID:
P54855
Molecular Weight:
61035.815 Da
References
  1. Chung JY, Cho JY, Yu KS, Kim JR, Jung HR, Lim KS, Jang IJ, Shin SG: Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers. Clin Pharmacol Ther. 2005 Jun;77(6):486-94. [PubMed:15961980 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23