Thrombosis, Venous

Also known as: Venous thrombosis / Thrombosis of vein NOS / Embolism of vein NOS / Thrombosis venous / Phlebothrombosis / Venous thrombosis NOS

DrugDrug NameDrug Description
DB01418AcenocoumarolAcenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, IX and X, and interferes with coagulation. Hematocrit, hemoglobin, international normalized ratio and liver panel should be monitored. Patients on acenocoumarol are prohibited from giving blood.
DB09255DextranDextran is a polysaccharide that differs from others in that its glucose units are joined together 1:6 glucoside links. The main chain of glucose has short branches at frequent intervals which are probably joined by 1:3 and 1:4 glucoside links. The chains can be composed of about 200,000 glucose units.[A32011] Many bacteria, like _Leuconostoc_, can synthesize dextran from sucrose, and this activity is used commercially to obtain dextran.[T121] Dextran 40 is a sterile, nonpyrogenic preparation of low molecular weight dextran (average mol. wt. 40,000) in 5% Dextrose Injection or 0.9% Sodium Chloride Injection. It is administered by intravenous infusion. Dextran 75 is a complex branched glucan with an average molecular weight 75000 Daltons. It is produced from certain bacteria that with α-1,6 glycosidic linkages between glucose molecules and α-1,3 linkages between branches. When labelled with technetium Tc99m, dextran 75 is intravenously administered as an imaging agent to detect and diagnose conditions in the vascular compartment such as pericardial effusion or ventricular aneurysm.
DB01109HeparinUnfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
DB00682WarfarinWarfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross the placental barrier during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death. Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
DrugDrug NamePhaseStatusCount
DB01022Phylloquinone1Completed1
DB09528Phylloquinone1Completed1
DB06228Rivaroxaban1Completed2
DB00682Warfarin1Completed1
DB06695Dabigatran etexilate2Completed1
DB09075Edoxaban2Completed1
DB01225Enoxaparin2Completed1
DB00569Fondaparinux2Completed1
DB09353Octasulfur2Completed1
DB06228Rivaroxaban2Completed3
DB00682Warfarin2Completed2
DB06605Apixaban2 / 3Completed1
DB01225Enoxaparin2 / 3Completed2
DB00682Warfarin2 / 3Completed1
DB00945Acetylsalicylic acid3Completed1
DB04919Alfimeprase3Completed2
DB00009Alteplase3Completed1
DB00009Alteplase3Withdrawn1
DB06605Apixaban3Completed3
DB09075Edoxaban3Completed1
DB01225Enoxaparin3Completed3
DB00016Erythropoietin3Completed1
DB00569Fondaparinux3Completed3
DB11728Fondaparinux3Completed2
DB00569Fondaparinux3Terminated1
DB01109Heparin3Completed4
DB08813Nadroparin3Completed2
DB06228Rivaroxaban3Completed2
DB01098Rosuvastatin3Withdrawn1
DB09153Sodium chloride3Not Yet Recruiting1
DB00302Tranexamic acid3Not Yet Recruiting1
DB00682Warfarin3Completed3
DB00945Acetylsalicylic acid4Completed1
DB00945Acetylsalicylic acid4Recruiting2
DB06605Apixaban4Completed1
DB00975Dipyridamole4Completed1
DB00975Dipyridamole4Recruiting1
DB01225Enoxaparin4Completed4
DB01225Enoxaparin4Unknown Status1
DB13136Fluindione4Recruiting1
DB08813Nadroparin4Completed1
DB08813Nadroparin4Recruiting1
DB06228Rivaroxaban4Recruiting2
DB06228Rivaroxaban4Terminated1
DB06822Tinzaparin4Completed2
DB00682Warfarin4Completed1
DB00682Warfarin4Recruiting3
DB00682Warfarin4Terminated1
DB06605ApixabanNot AvailableRecruiting1
DB06695Dabigatran etexilateNot AvailableRecruiting1
DB06779DalteparinNot AvailableCompleted1
DB09075EdoxabanNot AvailableRecruiting1
DB01225EnoxaparinNot AvailableCompleted1
DB01225EnoxaparinNot AvailableRecruiting2
DB01225EnoxaparinNot AvailableTerminated1
DB00977EthinylestradiolNot AvailableCompleted1
DB00569FondaparinuxNot AvailableCompleted1
DB11728FondaparinuxNot AvailableCompleted2
DB11728FondaparinuxNot AvailableTerminated1
DB01109HeparinNot AvailableCompleted2
DB01109HeparinNot AvailableTerminated1
DB01115NifedipineNot AvailableCompleted1
DB06713NorelgestrominNot AvailableCompleted1
DB00957NorgestimateNot AvailableCompleted1
DB06815PyrithioneNot AvailableCompleted1
DB06228RivaroxabanNot AvailableActive Not Recruiting1
DB06228RivaroxabanNot AvailableCompleted3
DB06228RivaroxabanNot AvailableRecruiting4
DB09099SomatostatinNot AvailableRecruiting1
DB06822TinzaparinNot AvailableTerminated1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00013UrokinaseNot AvailableEnrolling by Invitation1
DB00682WarfarinNot AvailableCompleted1
DB00682WarfarinNot AvailableRecruiting2