Open-angle Glaucoma (OAG)

Also known as: Open-angle glaucoma / Glaucoma, Open-angle / Open angle glaucoma NOS / Pigmentary glaucoma / Open angle glaucoma / Open-angle glaucoma NOS / Open-angle glaucoma, unspecified / Glaucoma simplex

DrugDrug NameDrug Description
DB00484BrimonidineAn alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea.
DB01194BrinzolamideA carbonic anhydrase inhibitor used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB00869DorzolamideA carbonic anhydrase inhibitor used to treat high intraocular pressure in ocular hypertension and open angle glaucoma.
DB01057EchothiophateAn acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.
DB00654LatanoprostAn isopropyl ester prodrug used to treat increased intraocular pressure.
DB01210LevobunololA beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB00703MethazolamideA carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma.
DB13931NetarsudilA rho kinase inhibitor used to reduce intraocular pressure in patients with open angle glaucoma or ocular hypertension.
DB01085PilocarpineA muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy.
DB08819TafluprostAn ophthalmic prostaglandin analog used to lower intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB00373TimololA non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma.
DB00287TravoprostA prostaglandin analog used in the treatment of elevated intraocular pressure due to open angle glaucoma or ocular hypertension.
DB06826UnoprostoneA prostaglandin analogue used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are clinically unresponsive to other ocular antihypertensive agents.
DrugDrug NameTargetType
DB00484BrimonidineAlpha-2A adrenergic receptortarget
DB00484BrimonidineAlpha-2B adrenergic receptortarget
DB00484BrimonidineAlpha-2C adrenergic receptortarget
DB00484BrimonidineAldehyde oxidaseenzyme
DB01194BrinzolamideCarbonic anhydrase 1target
DB01194BrinzolamideCarbonic anhydrase 2target
DB01194BrinzolamideCytochrome P450 3A4enzyme
DB01194BrinzolamideCarbonic anhydrase 5A, mitochondrialtarget
DB01194BrinzolamideCarbonic anhydrase 4target
DB01194BrinzolamideCarbonic anhydrase 3target
DB00869DorzolamideCarbonic anhydrase 2target
DB00869DorzolamideCarbonic anhydrase 1target
DB00869DorzolamideCarbonic anhydrase 4target
DB00869DorzolamideCytochrome P450 2C9enzyme
DB00869DorzolamideCarbonic anhydrase 3target
DB01057EchothiophateCholinesterasetarget
DB01057EchothiophateSerum albumincarrier
DB00654LatanoprostProstaglandin F2-alpha receptortarget
DB00654LatanoprostSolute carrier organic anion transporter family member 2A1transporter
DB00654LatanoprostSolute carrier family 22 member 6transporter
DB00654LatanoprostSolute carrier family 22 member 8transporter
DB00654LatanoprostCorneal esterasesenzyme
DB01210LevobunololBeta-1 adrenergic receptortarget
DB01210LevobunololBeta-2 adrenergic receptortarget
DB01210LevobunololCytochrome P450 2D6enzyme
DB00703MethazolamideCarbonic anhydrase 1target
DB00703MethazolamideSolute carrier family 22 member 6transporter
DB00703MethazolamideCarbonic anhydrase 4target
DB00703MethazolamideCarbonic anhydrase 2target
DB00703MethazolamideCarbonic anhydrase 7target
DB00703MethazolamideCarbonic anhydrase 3target
DB13931NetarsudilRho-associated protein kinase 1target
DB13931NetarsudilRho-associated protein kinase 2target
DB13931NetarsudilSodium-dependent noradrenaline transportertarget
DB01085PilocarpineMuscarinic acetylcholine receptor M1target
DB01085PilocarpineMuscarinic acetylcholine receptor M2target
DB01085PilocarpineCytochrome P450 2A6enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M3target
DB01085PilocarpineCytochrome P450 3A4enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M4target
DB08819TafluprostProstaglandin F2-alpha receptortarget
DB08819TafluprostProstaglandin G/H synthase 2enzyme
DB00373TimololBeta-1 adrenergic receptortarget
DB00373TimololBeta-2 adrenergic receptortarget
DB00373TimololCytochrome P450 2D6enzyme
DB00373TimololP-glycoprotein 1transporter
DB00373TimololCytochrome P450 2C19enzyme
DB00373TimololLysozymetarget
DB00287TravoprostProstaglandin F2-alpha receptortarget
DrugDrug NamePhaseStatusCount
DB00654Latanoprost1Completed1
DB01270Ranibizumab1Completed1
DB00373Timolol1Completed1
DB00905Bimatoprost1 / 2Completed2
DB12295Evodenoson1 / 2Completed1
DB00654Latanoprost1 / 2Completed1
DB00373Timolol1 / 2Completed3
DB05288Anecortave acetate2Completed3
DB05288Anecortave acetate2Terminated1
DB00905Bimatoprost2Completed3
DB00484Brimonidine2Completed2
DB00484Brimonidine2Terminated1
DB01194Brinzolamide2Completed3
DB01194Brinzolamide2Terminated1
DB01381Ginkgo biloba2Completed1
DB00654Latanoprost2Completed13
DB00654Latanoprost2Withdrawn1
DB15071Omidenepag isopropyl2Completed1
DB06195Seliciclib2Completed1
DB12977Simenepag isopropyl2Completed2
DB12623Taprenepag2Completed1
DB00373Timolol2Completed4
DB00287Travoprost2Completed5
DB00287Travoprost2Terminated1
DB05288Anecortave acetate2 / 3Completed1
DB05288Anecortave acetate2 / 3Withdrawn1
DB00869Dorzolamide2 / 3Completed1
DB00373Timolol2 / 3Completed1
DB00195Betaxolol3Unknown Status1
DB00905Bimatoprost3Active Not Recruiting1
DB00905Bimatoprost3Completed3
DB00905Bimatoprost3Enrolling by Invitation1
DB00905Bimatoprost3Recruiting2
DB00484Brimonidine3Completed8
DB01194Brinzolamide3Completed8
DB01194Brinzolamide3Recruiting1
DB00869Dorzolamide3Completed1
DB00654Latanoprost3Completed13
DB00654Latanoprost3Withdrawn1
DB11660Latanoprostene bunod3Completed2
DB01043Memantine3Completed2
DB13931Netarsudil3Completed5
DB08819Tafluprost3Completed5
DB00373Timolol3Active Not Recruiting1
DB00373Timolol3Completed25
DB00287Travoprost3Completed15
DB00287Travoprost3Recruiting2
DB00905Bimatoprost4Completed12
DB00484Brimonidine4Completed9
DB00484Brimonidine4Not Yet Recruiting1
DB00484Brimonidine4Terminated1
DB01194Brinzolamide4Completed6
DB01194Brinzolamide4Terminated1
DB01234Dexamethasone4Active Not Recruiting1
DB01234Dexamethasone4Completed1
DB00869Dorzolamide4Completed10
DB00869Dorzolamide4Terminated1
DB00544Fluorouracil4Recruiting1
DB00588Fluticasone propionate4Completed1
DB00654Latanoprost4Completed16
DB00654Latanoprost4Not Yet Recruiting1
DB00654Latanoprost4Recruiting1
DB11660Latanoprostene bunod4Recruiting1
DB14596Loteprednol etabonate4Completed1
DB00305Mitomycin4Recruiting1
DB13931Netarsudil4Completed1
DB01085Pilocarpine4Completed1
DB08819Tafluprost4Completed3
DB00373Timolol4Completed24
DB00373Timolol4Not Yet Recruiting1
DB00373Timolol4Terminated2
DB00373Timolol4Withdrawn1
DB00684Tobramycin4Active Not Recruiting1
DB00684Tobramycin4Completed1
DB00287Travoprost4Active Not Recruiting2
DB00287Travoprost4Completed15
DB00287Travoprost4Terminated4
DB00287Travoprost4Withdrawn1
DB00905BimatoprostNot AvailableCompleted10
DB00484BrimonidineNot AvailableCompleted1
DB00869DorzolamideNot AvailableWithdrawn1
DB00654LatanoprostNot AvailableCompleted2
DB00654LatanoprostNot AvailableUnknown Status1
DB00654LatanoprostNot AvailableWithdrawn1
DB00305MitomycinNot AvailableUnknown Status1
DB01085PilocarpineNot AvailableCompleted1
DB00373TimololNot AvailableCompleted5
DB00373TimololNot AvailableWithdrawn1
DB00287TravoprostNot AvailableCompleted1