Generalized Anxiety Disorder (GAD)

Also known as: Generalized anxiety disorder / Generalized Anxiety Disorders / Anxiety neurosis / Generalised anxiety disorder / GAD

DrugDrug NameDrug Description
DB00404AlprazolamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression.
DB00628Clorazepic acidA benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal.
DB00476DuloxetineA serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence.
DB01175EscitalopramA selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD).
DB00370MirtazapineA tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
DB00715ParoxetineA selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder.
DB01224QuetiapineA psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder.
DB01104SertralineA selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions.
DB00285VenlafaxineA selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression.
DrugDrug NameTargetType
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-1target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-6target
DB00404AlprazolamTranslocator proteintarget
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-3target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-4target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-5target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-2target
DB00404AlprazolamCytochrome P450 3A4enzyme
DB00404AlprazolamCytochrome P450 2C9enzyme
DB00404AlprazolamCytochrome P450 3A5enzyme
DB00404AlprazolamCytochrome P450 3A7enzyme
DB00404AlprazolamGABA-A receptor (anion channel)target
DB00404AlprazolamSerum albumincarrier
DB00404Alprazolamalpha1-acid glycoproteincarrier
DB00628Clorazepic acidTranslocator proteintarget
DB00628Clorazepic acidCytochrome P450 3A4enzyme
DB00628Clorazepic acidGABA-A receptor (anion channel)target
DB00476DuloxetineSodium-dependent serotonin transportertarget
DB00476DuloxetineSodium-dependent dopamine transportertarget
DB00476DuloxetineSodium-dependent noradrenaline transportertarget
DB00476DuloxetineCytochrome P450 1A2enzyme
DB00476DuloxetineCytochrome P450 2D6enzyme
DB00476DuloxetineCytochrome P450 2C9enzyme
DB00476DuloxetineSerum albumincarrier
DB00476Duloxetinealpha1-acid glycoproteincarrier
DB00476DuloxetineP-glycoprotein 1transporter
DB01175EscitalopramSodium-dependent serotonin transportertarget
DB01175EscitalopramCytochrome P450 3A4enzyme
DB01175EscitalopramCytochrome P450 2D6enzyme
DB01175EscitalopramSodium-dependent dopamine transportertarget
DB01175EscitalopramSodium-dependent noradrenaline transportertarget
DB01175EscitalopramMuscarinic acetylcholine receptor M1target
DB01175EscitalopramHistamine H1 receptortarget
DB01175EscitalopramCytochrome P450 2C19enzyme
DB01175EscitalopramMonoamine oxidaseenzyme
DB01175EscitalopramP-glycoprotein 1transporter
DB01175Escitalopram5-hydroxytryptamine receptor 1Atarget
DB01175Escitalopram5-hydroxytryptamine receptor 2Atarget
DB01175Escitalopram5-hydroxytryptamine receptor 2Ctarget
DB01175EscitalopramAlpha-1 adrenergic receptorstarget
DB01175EscitalopramAlpha-2 adrenergic receptorstarget
DB01175EscitalopramDopamine D2 receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Atarget
DB00370Mirtazapine5HT3 serotonin receptortarget
DB00370MirtazapineAlpha-2A adrenergic receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Ctarget
DB00370MirtazapineKappa-type opioid receptortarget
DB00370MirtazapineHistamine H1 receptortarget
DB00370MirtazapineCytochrome P450 1A2enzyme
DB00370MirtazapineCytochrome P450 3A4enzyme
DB00370MirtazapineCytochrome P450 2D6enzyme
DB00370MirtazapineAlpha-1 adrenergic receptorstarget
DB00370MirtazapineSodium-dependent serotonin transportertransporter
DB00715ParoxetineSodium-dependent serotonin transportertarget
DB00715ParoxetineSodium-dependent noradrenaline transportertarget
DB00715Paroxetine5-hydroxytryptamine receptor 2Atarget
DB00715ParoxetineCytochrome P450 2D6enzyme
DB00715ParoxetineCytochrome P450 2C9enzyme
DB00715ParoxetineP-glycoprotein 1transporter
DB00715ParoxetineCytochrome P450 2B6enzyme
DB00715ParoxetineCytochrome P450 1A2enzyme
DB00715ParoxetineCytochrome P450 3A4enzyme
DB00715ParoxetineAlpha-1 adrenergic receptorstarget
DB00715ParoxetineAlpha-2 adrenergic receptorstarget
DB00715ParoxetineBeta adrenergic receptortarget
DB00715ParoxetineDopamine D2 receptortarget
DB00715ParoxetineHistamine H1 receptortarget
DB00715ParoxetineSerotonin Receptorstarget
DB00715ParoxetineMuscarinic acetylcholine receptortarget
DB00715Paroxetine5-hydroxytryptamine receptor 2Btarget
DB00715ParoxetineD(1) dopamine receptortarget
DB00715ParoxetineCytochrome P450 2C19enzyme
DB01224Quetiapine5-hydroxytryptamine receptor 2Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 2Ctarget
DB01224QuetiapineDopamine D2 receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Atarget
DB01224QuetiapineHistamine H1 receptortarget
DB01224QuetiapineCytochrome P450 3A4enzyme
DB01224QuetiapineAlpha-1 adrenergic receptorstarget
DB01224QuetiapineAlpha-2A adrenergic receptortarget
DB01224QuetiapineAlpha-2B adrenergic receptortarget
DB01224QuetiapineAlpha-2C adrenergic receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Dtarget
DB01224QuetiapineMuscarinic acetylcholine receptor M1target
DB01224QuetiapineMuscarinic acetylcholine receptor M2target
DB01224QuetiapineMuscarinic acetylcholine receptor M3target
DB01224QuetiapineMuscarinic acetylcholine receptor M4target
DB01224QuetiapineMuscarinic acetylcholine receptor M5target
DB01224Quetiapine5-hydroxytryptamine receptor 1Btarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Etarget
DB01224Quetiapine5-hydroxytryptamine receptor 3Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 6target
DB01224Quetiapine5-hydroxytryptamine receptor 7target
DB01224QuetiapineDopamine D5 receptortarget
DB01224QuetiapineDopamine D1 receptortarget
DB01224QuetiapineDopamine D3 receptortarget
DB01224QuetiapineDopamine D4 receptortarget
DB01224QuetiapineCytochrome P450 3A5enzyme
DB01224QuetiapineP-glycoprotein 1transporter
DB01224QuetiapineCytochrome P450 2C19enzyme
DB01224QuetiapineCytochrome P450 2D6enzyme
DB01224QuetiapineCytochrome P450 3A7enzyme
DB01104SertralineSodium-dependent serotonin transportertarget
DB01104SertralineCytochrome P450 2B6enzyme
DB01104SertralineCytochrome P450 2C19enzyme
DB01104SertralineCytochrome P450 2C9enzyme
DB01104SertralineCytochrome P450 2D6enzyme
DB01104SertralineSodium-dependent dopamine transportertarget
DB01104SertralineCYP2B proteinenzyme
DB01104SertralineCytochrome P450 3A4enzyme
DB01104SertralineAmine oxidase [flavin-containing] Benzyme
DB01104SertralineAmine oxidase [flavin-containing] Aenzyme
DB01104SertralineP-glycoprotein 1transporter
DB01104SertralineSerum albumincarrier
DB01104SertralineSigma receptortarget
DB00285VenlafaxineSodium-dependent serotonin transportertarget
DB00285VenlafaxineSodium-dependent noradrenaline transportertarget
DB00285VenlafaxineCytochrome P450 2D6enzyme
DB00285VenlafaxineCytochrome P450 3A4enzyme
DB00285VenlafaxineSodium-dependent dopamine transportertarget
DB00285VenlafaxineP-glycoprotein 1transporter
DB00285VenlafaxineATP-binding cassette sub-family G member 2transporter
DrugDrug NamePhaseStatusCount
DB00501Cimetidine1Terminated1
DB12105Imagabalin1Completed1
DB12105Imagabalin1Terminated2
DB00331Metformin1Terminated1
DB00715Paroxetine1Completed1
DB00404Alprazolam2Completed1
DB00404Alprazolam2Recruiting1
DB00402Eszopiclone2Completed1
DB01018Guanfacine2Completed1
DB12105Imagabalin2Completed1
DB01202Levetiracetam2Completed1
DB12238MK-07772Completed2
DB06201Rufinamide2Completed1
DB00285Venlafaxine2Completed1
DB01175Escitalopram2 / 3Completed1
DB12572Pexacerfont2 / 3Completed1
DB09061Cannabidiol3Not Yet Recruiting1
DB14357Chamomile3Completed1
DB00476Duloxetine3Completed2
DB01175Escitalopram3Completed1
DB01175Escitalopram3Recruiting1
DB00176Fluvoxamine3Completed1
DB12105Imagabalin3Completed1
DB12105Imagabalin3Terminated4
DB12105Imagabalin3Withdrawn1
DB00186Lorazepam3Completed1
DB01043Memantine3Completed1
DB00715Paroxetine3Completed1
DB00715Paroxetine3Terminated3
DB00230Pregabalin3Completed2
DB01224Quetiapine3Completed3
DB01224Quetiapine3Terminated1
DB01104Sertraline3Unknown Status1
DB00906Tiagabine3Completed2
DB15079Troriluzole3Active Not Recruiting1
DB06684Vilazodone3Completed2
DB05700Vortioxetine3Completed5
DB09068Vortioxetine3Completed5
DB00659Acamprosate4Completed1
DB00404Alprazolam4Completed2
DB01238Aripiprazole4Completed1
DB06700Desvenlafaxine4Recruiting1
DB00476Duloxetine4Completed2
DB01175Escitalopram4Completed3
DB01175Escitalopram4Recruiting1
DB00402Eszopiclone4Completed1
DB00186Lorazepam4Completed2
DB00422Methylphenidate4Recruiting1
DB00230Pregabalin4Completed1
DB01224Quetiapine4Completed1
DB01224Quetiapine4Terminated2
DB01224Quetiapine4Unknown Status1
DB00734Risperidone4Completed1
DB01104Sertraline4Completed2
DB12833Tandospirone4Recruiting1
DB00313Valproic acid4Unknown Status1
DB00246Ziprasidone4Completed1
DB00246Ziprasidone4Terminated1
DB00476DuloxetineNot AvailableActive Not Recruiting1
DB00476DuloxetineNot AvailableNo Longer Available1
DB01175EscitalopramNot AvailableActive Not Recruiting1
DB01175EscitalopramNot AvailableCompleted2
DB00472FluoxetineNot AvailableActive Not Recruiting2
DB00472FluoxetineNot AvailableCompleted1
DB00176FluvoxamineNot AvailableCompleted1
DB01064IsoprenalineNot AvailableRecruiting1
DB00422MethylphenidateNot AvailableCompleted1
DB00715ParoxetineNot AvailableActive Not Recruiting1
DB01224QuetiapineNot AvailableCompleted2
DB01224QuetiapineNot AvailableTerminated1
DB01104SertralineNot AvailableActive Not Recruiting1
DB00285VenlafaxineNot AvailableActive Not Recruiting1