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Displaying drugs 51 - 75 of 8746 in total
Codeine
The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease...
Approved
Illicit
Matched Synonyms: … morphine 3-methyl ether ... morphine-3-methyl ether ... 7,8-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol …
Matched Mixtures name: … Acet 3 ... Phenaphen No 3 Cap ... Phenaphen No.3 Cap …
Matched Mixtures name: … Acet 3 ... Phenaphen No 3 Cap ... Phenaphen No.3 Cap …
Ciprofloxacin
Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics. It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493]
The first ciprofloxacin containing product was FDA approved on 22 October 1987.
Approved
Investigational
Matched Synonyms: … 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid ... 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid ... 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid …
Matched Iupac: … 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid …
Matched Mixtures name: … InfectoCiproCort 3 mg/ml + 0,25 mg/ml Ohrentropfen, Lösung …
Matched Products: … NOVAFLOX EYE DROPS 3 mg/ml ... CILOXAN STERILE OPHTHALMIC OINTMENT 3 mg/g …
Matched Iupac: … 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid …
Matched Mixtures name: … InfectoCiproCort 3 mg/ml + 0,25 mg/ml Ohrentropfen, Lösung …
Matched Products: … NOVAFLOX EYE DROPS 3 mg/ml ... CILOXAN STERILE OPHTHALMIC OINTMENT 3 mg/g …
Fluoxymesterone
An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women.
Approved
Illicit
Matched Synonyms: … 11β,17β-Dihydroxy-9α-fluoro-17α-methyl-4-androster-3-one ... 9-Fluoro-11β,17β-dihydroxy-17-methylandrost-4-en-3-one …
Matched Categories: … 3-Oxoandrosten (4) Derivatives …
Matched Categories: … 3-Oxoandrosten (4) Derivatives …
Rofecoxib
Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 )...
Approved
Investigational
Withdrawn
Matched Synonyms: … 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone ... 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone …
Matched Iupac: … 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one …
Matched Iupac: … 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one …
Nefazodone
Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with...
Approved
Withdrawn
Matched Synonyms: … 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one …
Matched Iupac: … 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol …
Matched Iupac: … 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol …
Lumacaftor
Lumacaftor is a drug used in combination with DB08820 as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic...
Approved
Matched Synonyms: … 3-(6-{[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]amino}-3-methylpyridin-2-yl)benzoic …
Matched Iupac: … 3-{6-[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropaneamido]-3-methylpyridin-2-yl}benzoic acid …
Matched Iupac: … 3-{6-[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropaneamido]-3-methylpyridin-2-yl}benzoic acid …
Amprenavir
Amprenavir is a protease inhibitor used to treat HIV infection.
Approved
Investigational
Matched Synonyms: … (3S)-Tetrahydro-3-furanyl ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl …
Matched Iupac: … (3S)-oxolan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)4-aminobenzenesulfonamido]-1-phenylbutan-2 …
Matched Iupac: … (3S)-oxolan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)4-aminobenzenesulfonamido]-1-phenylbutan-2 …
Berdazimer
Berdazimer is a polymeric substance consisting of a polysiloxane backbone (Si-O-Si bonds) with covalently bound N-diazeniumdiolate nitric oxide (NO) donors. It releases NO through exposure to proton donors like water, which will degrade the N-diazeniumdiolate entity. Berdazimer was previously investigated as a potential treatment for molluscum contagiosum, a viral cutaneous...
Approved
Matched Synonyms: … Silsesquioxanes, 3-(2-hydroxy-1-methyl-2-nitrosohydrazinyl)propyl 3-(methylamino)propyl, polymers with …
Matched Description: … This decision is based on positive results demonstrated in 2 Phase 3 trials, B-SIMPLE 4 and B-SIMPLE …
Matched Description: … This decision is based on positive results demonstrated in 2 Phase 3 trials, B-SIMPLE 4 and B-SIMPLE …
Dobutamine
A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Approved
Matched Synonyms: … (±)-4-(2-((3-(p-hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol ... 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenylethylamine ... 4-{2-[3-(4-Hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol …
Ofloxacin
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Approved
Matched Synonyms: … 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic …
Matched Products: … Floxal 3 mg/g Augensalbe ... VisioFlox 3 mg/g Augensalbe ... Ofloxa-Vision 3 mg/g Augensalbe …
Matched Products: … Floxal 3 mg/g Augensalbe ... VisioFlox 3 mg/g Augensalbe ... Ofloxa-Vision 3 mg/g Augensalbe …
Bisoprolol
Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor...
Approved
Matched Synonyms: … (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol ... (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol …
Matched Iupac: … 1-[(propan-2-yl)amino]-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol …
Matched Iupac: … 1-[(propan-2-yl)amino]-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol …
Scopolamine
Scopolamine is a tropane alkaloid isolated from members of the Solanaceae family of plants, similar to atropine and hyoscyamine, all of which structurally mimic the natural neurotransmitter acetylcholine.[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine...
Approved
Investigational
Matched Synonyms: … (1S,3S,5R,6R,7S)-6,7-Epoxytropan-3-yl (2S)-3-hydroxy-2-phenylpropanoate ... 6-beta,7-beta-Epoxy-3-alpha-tropanyl S-(-)-tropate ... alpha-(Hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester …
Matched Iupac: … (1R,2R,4S,5S,7S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate …
Matched Iupac: … (1R,2R,4S,5S,7S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate …
Dextromethorphan
Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]
Approved
Matched International brands: … Vicks Formula 44 …
Matched Description: … [A215412] Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] …
Matched Salts cas: … 7487-74-3 …
Matched Mixtures name: … 44 ... Vicks 44 D ... XL-3 Xtra …
Matched Products: … easybronchial STOP FORTE 3 mg/ml Sirup ... Vicks 44 Cough Relief ... Vicks Formula 44 Cough …
Matched Description: … [A215412] Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] …
Matched Salts cas: … 7487-74-3 …
Matched Mixtures name: … 44 ... Vicks 44 D ... XL-3 Xtra …
Matched Products: … easybronchial STOP FORTE 3 mg/ml Sirup ... Vicks 44 Cough Relief ... Vicks Formula 44 Cough …
Phenmetrazine
A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine.
Approved
Illicit
Matched Synonyms: … 2-phenyl-3-methylmorpholine …
Matched Iupac: … 3-methyl-2-phenylmorpholine …
Matched Iupac: … 3-methyl-2-phenylmorpholine …
Mupirocin
Mupirocin, formerly termed pseudomonic acid A, is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. Produced by fermentation using the organism Pseudomonas fluorescens, mupirocin is a naturally-occurring antibiotic that displays a broad-specturm activity against many gram-positive bacteria and certain gram-negative...
Approved
Investigational
Vet approved
Matched Synonyms: … 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3- [(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] ... oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid …
Matched Iupac: … 9-{[(2E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-{[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl ... }oxan-2-yl]-3-methylbut-2-enoyl]oxy}nonanoic acid …
Matched Iupac: … 9-{[(2E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-{[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl ... }oxan-2-yl]-3-methylbut-2-enoyl]oxy}nonanoic acid …
Chlorpheniramine
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
Approved
Matched Synonyms: … 3-(p-chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine ... 1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane ... 1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine …
Matched Iupac: … [3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine …
Matched Mixtures name: … Vicks 44 M ... XL-3 Cold ... XL-3 Xtra …
Matched Iupac: … [3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine …
Matched Mixtures name: … Vicks 44 M ... XL-3 Cold ... XL-3 Xtra …
PBT-434
Approved
Investigational
Matched Synonyms: … 5,7-dichloro-2-((ethylamino)methyl)-8-hydroxy-3-methylquinazolin-4(3h)-one …
Matched Iupac: … 5,7-dichloro-2-[(ethylamino)methyl]-8-hydroxy-3-methyl-3,4-dihydroquinazolin-4-one …
Matched Iupac: … 5,7-dichloro-2-[(ethylamino)methyl]-8-hydroxy-3-methyl-3,4-dihydroquinazolin-4-one …
Olaparib
Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Olaparib...
Approved
Matched Synonyms: … 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one …
Matched Iupac: … 4-{[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorophenyl]methyl}-1,2-dihydrophthalazin-1-one …
Matched Iupac: … 4-{[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorophenyl]methyl}-1,2-dihydrophthalazin-1-one …
Dienogest
Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not...
Approved
Matched Synonyms: … 17-alpha-Cyanomethyl-17-beta-hydroxy-estra-4,9(10)-dien-3-one ... 17alpha-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile …
Vorapaxar
Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expressed on platelets, vorapaxar prevents thrombin-related platelet aggregation.
Approved
Matched Synonyms: … [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-Fluorophényl)-2-pyridinyl]vinyl}-1-méthyl-3-oxododécahydronaphto ... Ethyl N-[(3R,3aS,4S,4aR,7R,8aR,9aR)-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridyl]vinyl]-3-methyl-1-oxo-3a,4,4a ... -1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester …
Matched Iupac: … ethyl N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-dodecahydronaphtho …
Matched Iupac: … ethyl N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-dodecahydronaphtho …
Dyclonine
Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It may also be found in some Cepacol sore throat spray products.
Approved
Matched Synonyms: … 3-piperidino-4'-butoxypropiophenone ... 4'-butoxy-3-piperidinopropiophenone ... 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone …
Matched Iupac: … 1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one …
Matched Iupac: … 1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one …
Temozolomide
Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alkylating agents, although they invariably develop resistance to these...
Approved
Investigational
Matched Synonyms: … 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one ... 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide ... 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide …
Matched Iupac: … 3-methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide …
Matched Iupac: … 3-methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide …
Perphenazine
An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.
Approved
Matched Synonyms: … 4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol ... 2-(4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol ... 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol …
Matched Iupac: … 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethan-1-ol …
Matched Mixtures name: … Apo Peram Tab 3-15 ... PMS-levazine 3/15 Tab …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Matched Iupac: … 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethan-1-ol …
Matched Mixtures name: … Apo Peram Tab 3-15 ... PMS-levazine 3/15 Tab …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Lotilaner
Lotilaner is an ectoparasiticide that is a member of the isoxazoline family of compounds. Lotilaner has largely been used for veterinary uses as an antiparasitic agent to treat flea and tick infestations in animals.[A260746, L47556] Lotilaner consists of two enantiomers: the S-enantiomer is active in vivo, while the R-enantiomer is...
Approved
Vet approved
Matched Synonyms: … )-4,5-dihydro-1,2-oxazol-3-yl)thiophene-2-carboxamide ... )-3-methyl-n-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)- ... 2-thiophenecarboxamide, 5-((5s)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl …
Matched Iupac: … 2-({3-methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophen …
Matched Iupac: … 2-({3-methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophen …
Methotrimeprazine
A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
Approved
Investigational
Matched Synonyms: … (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine ... (-)-(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine …
Matched Iupac: … [(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]dimethylamine …
Matched Salts cas: … 1236-99-3 ... 7104-38-3 …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Matched Iupac: … [(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]dimethylamine …
Matched Salts cas: … 1236-99-3 ... 7104-38-3 …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Displaying drugs 51 - 75 of 8746 in total