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Displaying drugs 51 - 75 of 11582 in total
Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is sold under the name "Colazal" in the US and "Colazide" in the UK. The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. It is usually administered as the disodium salt. Balsalazide works by deliverying mesalazine...
Approved
Investigational
Matched Synonyms: … (E)-5-({p-[(2-carboxyethyl)carbamoyl]phenyl}azo)-2-salicylic acid ... (E)-5-((4-(((2-carboxyethyl)amino)carbonyl)phenyl)azo)-2-hydroxybenzoic acid ... 5-[4-(2-carboxy-ethylcarbamoyl)-phenylazo]-2-hydroxy-benzoic acid …
Matched Iupac: … 5-[(1E)-2-{4-[(2-carboxyethyl)carbamoyl]phenyl}diazen-1-yl]-2-hydroxybenzoic acid …
Matched Description: … The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. …
Matched Categories: … Non COX-2 selective NSAIDS …
A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
Approved
Matched Synonyms: … 5-chloro-2-benzoxazolol ... 5-chloro-2-benzoxazolone ... 5-chloro-2-benzoxazolinone …
Matched Iupac: … 5-chloro-2,3-dihydro-1,3-benzoxazol-2-one …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is...
Approved
Investigational
Matched Synonyms: … 2',3'-Dideoxycytidine ... 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one …
Matched Iupac: … 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one …
Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds...
Approved
Matched Synonyms: … 10-(2-Dimethylaminopropyl)-2-propionylphenothiazine ... 2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazine …
Matched Iupac: … 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one …
Matched Description: … to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2
Povidone, also known as polyvinylpyrrolidone (PVP) or polyvidone, is a synthetic water-soluble polymer made from the monomer N-vinylpyrrolidone used as a binder in many pharmaceutical tablets and lubricant in eye drops. It is also used in many technical applications with various roles as an adhesive, additive, and emulsifier. When in...
Approved
Withdrawn
Matched Synonyms: … 1-vinyl-2-pyrrolidinone polymer ... 1-ethenyl-2-pyrrolidinone homopolymer …
Matched Products: … VIDISEPT 2% …
Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.
Approved
Investigational
Matched Synonyms: … 1-(2',6'-dimethylphenoxy)-2-aminopropane ... 1-methyl-2-(2,6-xylyloxy)ethanamine ... (±)-1-(2,6-dimethylphenoxy)propan-2-amine …
Matched Iupac: … 1-(2,6-dimethylphenoxy)propan-2-amine …
Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced.
Approved
Matched Synonyms: … (E)-3-[2-n-butyl-1-{(4-carboxyphenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid ... (E)-2-butyl-1-(p-carboxybenzyl)-α-2-thenylimidazole-5-acrylic acid ... (E)-α{[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazole-5-yl]methylene}-2-thiopheneproprionic acid …
Matched Iupac: … 4-({2-butyl-5-[(1E)-2-carboxy-2-[(thiophen-2-yl)methyl]eth-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic …
Matched Description: … It performs 2 actions on the renin angiotensin system. …
Matched Categories: … Angiotensin 2 Receptor Blocker …
Viloxazine is a selective norepinephrine reuptake inhibitor. For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant. It was first approved in the UK in 1974; however, the immediate-release formulation was discontinued due to business reasons unrelated to drug safety and efficacy. In the US,...
Approved
Investigational
Withdrawn
Matched Synonyms: … 2-((2-Ethoxyphenoxy)methyl)morpholine …
Matched Iupac: … 2-[(2-ethoxyphenoxy)methyl]morpholine …
Matched Salts cas: … 35604-67-2
Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver failure. New Zealand and Canada have also followed suit in recalling...
Approved
Investigational
Matched Synonyms: … 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid …
Matched Iupac: … 2-{2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid …
Matched Description: … Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). …
Matched Categories: … COX-2 Inhibitors ... Selective Cyclooxygenase 2 Inhibitors (NSAIDs) …
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Synonyms: … 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine ... 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine ... N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine …
Matched Iupac: … (Z)-N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine …
Matched Salts cas: … 70059-30-2
Matched Mixtures name: … Cimetidine 5% / Ibuprofen 2% / Salicylic Acid 17% …
Matched Categories: … MATE 2 Inhibitors ... MATE 2 Substrates …
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Approved
Matched Products: … Demerol 75 mg/ml ... ALDOLAN 100 MG/2 ML AMPUL, 5 ADET ... MEPERIDINA CLORHIDRATO 100 MG/2 ML …
Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available in its salt form, cisatracurium besylate.[A243416,A253592] Cisatracurium has an intermediate duration of action and is one of the most commonly used neuromuscular blocking agents in intensive care.[A253592,A253597]. Cisatracurium acts on cholinergic receptors, blocking neuromuscular transmission. This action is...
Approved
Investigational
Matched Synonyms: … -dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] ... (1r,2r,1'r,2'r)-2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7 …
Matched Iupac: … -2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium ... -2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl]propanoyl}oxy)pentyl]oxy}-3-oxopropyl)-6,7-dimethoxy ... (1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-2-(3-{[5-({3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Products: … Nimbex Injection 2 mg/ml ... นิมเบ็กซ์ (ชนิดฉีด 2 มก./มล.) ... Nimbex 2 mg/ml - Injektions-/Infusionslösung …
Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral alpha (α)-adrenergic properties. Available since the 1950s, tetryzoline is a selective α1-receptor agonist that is used as an ocular and nasal decongestant. Tetryzoline is found in a wide array of over-the-counter eye drops, including the most...
Approved
Matched Synonyms: … 2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline ... 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole ... (RS)-2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole …
Matched Iupac: … 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole …
Matched Products: … Murine Plus 2
Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times higher than that of the first generation...
Approved
Investigational
Matched Synonyms: … N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide …
Matched Iupac: … N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide …
Matched Description: … inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Approved
Investigational
Matched Synonyms: … 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)triethylamine ... 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine ... 2-(p-(β-chloro-α-phenylstyryl)phenoxy)triethylamine …
Matched Iupac: … {2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]ethyl}diethylamine …
Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the arylpropionic acid (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Approved
Matched Synonyms: … 2-(5-Benzyl-2-thienyl)propionsäure ... 2-(5-Benzoyl-thiophen-2-yl)-propionic acid ... 5-benzoyl-α-methyl-2-thiopheneacetic acid …
Matched Iupac: … 2-(5-benzoylthiophen-2-yl)propanoic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including DB00916 and DB00911, but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria as well as protozoa. Once...
Approved
Matched Synonyms: … 1-(2­ hydroxypropyl)-2-methyl-5-nitroimidazole ... 1-(2-methyl-5-nitro-1H-imidazol-1-yl) propan-2­ ol …
Matched Iupac: … 1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol …
Matched Products: … SECNIZOL® 2 G ... SECNIDOX 1000 MG FILM TABLET,2 ADET ... SECNIDOX 500 MG FILM TABLET ,2 FILM TABLET …
Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down into mesalazine and sulfapyridine, 2 compounds that carry out the main pharmacological...
Approved
Matched Synonyms: … 2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid ... 2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid ... 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid …
Matched Iupac: … 2-hydroxy-5-[(E)-2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl]benzoic acid …
Matched Description: … Metabolized by intestinal bacteria, sulfasalazine is broken down into [mesalazine] and [sulfapyridine], 2
Matched Categories: … Non COX-2 selective NSAIDS …
Antazoline is a 1st generation antihistamine with anticholinergic activity. It is used to relieve nasal congestion. It is also formulated as eye drops with naphazoline to relieve allergic conjunctivitis.
Approved
Matched Synonyms: … 2-(N-Benzylanilinomethyl)-2-imidazoline ... 2-(N-Phenyl-N-benzylaminomethyl)imidazoline ... 4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine …
Matched Iupac: … N-benzyl-N-[(4,5-dihydro-1H-imidazol-2-yl)methyl]aniline …
A semi-synthetic cephalosporin antibiotic.
Approved
Matched Synonyms: … oct-2-ene-2-carboxylic acid ... ]oct-2-ene-2-carboxylic acid ... 7-(D-2-Amino-2-(1,4-cyclohexadienyl)acetamide)desacetoxycephalosporanicacid …
Matched Iupac: … ]oct-2-ene-2-carboxylic acid ... (6R,7R)-7-[(2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0 …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Florbetapir (18F) is a radiopharmaceutical compound containing the radionuclide fluorine-18 bound to the compound florbetapir, a molecule that binds with high affinity to beta amyloid plaque, a peptide that plays a key role in Alzheimer's Disease pathogenesis. Marketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography...
Approved
Investigational
Matched Synonyms: … 4-{(E)-2-[6-(2-{2-[2-(18F)fluoroethoxy]ethoxy}ethoxy)pyridin-3-yl]ethenyl}-N-methylaniline …
Matched Iupac: … 4-[(E)-2-[6-(2-{2-[2-(¹⁸F)fluoroethoxy]ethoxy}ethoxy)pyridin-3-yl]ethenyl]-N-methylaniline …
Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved testing...
Approved
Matched Synonyms: … N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino ... }phenyl)prop-2-enamide …
Matched Iupac: … N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino ... }phenyl)prop-2-enamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to...
Approved
Investigational
Matched Synonyms: … 4'-((4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid ... 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid ... 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid …
Matched Iupac: … ]-2-carboxylic acid ... 4'-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}-[1,1'-biphenyl …
Matched Categories: … Angiotensin 2 Receptor Blocker ... Heterocyclic Compounds, 2-Ring ... Angiotensin II Type 2 Receptor Blockers …
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was generally well tolerated, with the majority of adverse effects being mild,...
Approved
Vet approved
Withdrawn
Matched Synonyms: … 2-(6-Chloro-9H-carbazol-2-yl)-propionic acid ... (±)-6-chloro-α-methylcarbazole-2-acetic acid ... (+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid …
Matched Iupac: … 2-(6-chloro-9H-carbazol-2-yl)propanoic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Selective Cyclooxygenase 2 Inhibitors (NSAIDs) …
Profenamine (also known as ethopropazine) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat Parkinsonism. It is sold under the trade name Parsitan in Canada. In the US, the marketing of profenamine has been discontinued.
Approved
Matched Synonyms: … 10-[2-(diethylamino)-2-methylethyl]phenothiazine ... 10-(2-diethylaminopropyl)phenothiazine ... 10-[2-(diethylamino)propyl]phenothiazine …
Matched Iupac: … diethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine …
Matched Salts cas: … 1094-08-2
Displaying drugs 51 - 75 of 11582 in total