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Displaying drugs 101 - 125 of 12440 in total
Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative. To this date,...
Approved
Investigational
Matched Synonyms: … 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol …
Matched Iupac: … 1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol …
Matched Salts cas: … 119637-66-0
Matched Products: … METOPROLOL ABZ 0.K. 50MG ... METOPROLOL ABZ 0.K. 100MG ... METOPROLOL ABZ 0.K. 200MG …
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as...
Approved
Investigational
Matched Synonyms: … (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol …
Matched Iupac: … 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol …
Matched Description: … ,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2
Matched Salts cas: … 610309-89-2
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, 3-Ring …
Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and apoptosis of cancer cells,...
Approved
Investigational
Matched Synonyms: … [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid ... N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide …
Matched Iupac: … [(1R)-3-methyl-1-[(2S)-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamido]butyl]boronic acid …
Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic exposure of coadministered agents that are metabolized...
Approved
Matched Synonyms: … 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl} ... amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate …
Matched Iupac: … (1,3-thiazol-5-yl)methyl N-[(2R,5R)-5-[(2S)-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl ... ]amino}-4-(morpholin-4-yl)butanamido]-1,6-diphenylhexan-2-yl]carbamate …
A pyrazine that is used therapeutically as an antitubercular agent.
Approved
Investigational
Matched Synonyms: … 2-carbamylpyrazine ... 2-pyrazinecarboxamide ... pyrazine-2-carboxamide …
Matched Iupac: … pyrazine-2-carboxamide …
Matched Mixtures name: … PRO TB 3 KID ... RINCURE ® 3 FDC TABLETAS CON PELICULA …
Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties. It is found within many commercially available cosmetics, lotions, and makeup removers. It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness,...
Approved
Experimental
Matched Synonyms: … 5-Chloro-2-methyl-3(2H)-isothiazolone ... 4-Isothiazolin-3-one, 5-chloro-2-methyl- ... 5-Chloro-N-methylisothiazolin-3-one …
Matched Iupac: … 5-chloro-2-methyl-2,3-dihydro-1,2-thiazol-3-one …
Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII)....
Approved
Matched Synonyms: … (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta ... (b)pyrrole-2-carboxylic acid …
Matched Iupac: … b]pyrrole-2-carboxylic acid ... (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[ …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
First synthesized in the early 1980s, itraconazole is a broad-spectrum triazole antifungal agent used to treat a variety of infections. It is a 1:1:1:1 racemic mixture of four diastereomers, made up of two enantiomeric pairs, each possessing three chiral centers. Itraconazole was first approved in the US in 1992 and...
Approved
Investigational
Matched Synonyms: … 3H-1,2,4-TRIAZOL-3-ONE, 4-(4-(4-(4-((2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN ... (SUP 2)-1,2,4-TRIAZOLIN-5-ONE ... (±)-1-SEC-BUTYL-4-(P-(4-(P-(((2R*,4S*)-2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN …
Matched Iupac: … 1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan …
Matched Mixtures name: … Ciclopirox 3% / Itraconazole 5% / Urea 20% ... Fluconazole 4% / Ibuprofen 2% / Itraconazole 1% / Terbinafine HCl 4% …
An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items...
Approved
Investigational
Matched Synonyms: … 2,4,4'-Trichloro-2'-hydroxydiphenyl ether ... 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol …
Matched Iupac: … 5-chloro-2-(2,4-dichlorophenoxy)phenol …
Matched Description: … An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy …
Matched Mixtures name: … PREVENT 2 EN 1 ... APRIL Bath and Shower Anti-bacterial Hand 3 Pack ... APRIL Bath and Shower Anti-bacterial Hand 3 Pack …
Matched Products: … Orasoft 3 ... DawnMist Deodorant Bar No. 1/2 ... DawnMist Deodorant Bar No. 1 1/2
Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric...
Approved
Investigational
Matched Synonyms: … N-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4,5-trimethoxybenzamide …
Matched Iupac: … N-({4-[2-(dimethylamino)ethoxy]phenyl}methyl)-3,4,5-trimethoxybenzamide …
Matched Products: … VOMET 2 ML 200 MG 6 AMPUL ... VOSELMIT 200 MG 2 ML 6 AMPUL ... EMEDUR 200 MG/2 ML IM ENJEKSİYONLUK ÇÖZELTİ, 50 ADET …
A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.
Approved
Investigational
Matched Synonyms: … 1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitroimidazole …
Matched Iupac: … 1-[2-(ethanesulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole …
Matched Mixtures name: … TRİVAG 300 MG / 200 MG/ 100 MG OVÜL, 3 ADET ... GYNOMAX XL 200 MG/ 300 MG/100 MG VAJINAL OVÜL, 3 ADET …
A benzodiazepine derivative used as an anticonvulsant and hypnotic.
Approved
Matched Synonyms: … 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one ... 2,3-dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one ... 7-nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one …
Matched Iupac: … 7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Approved
Investigational
Nutraceutical
Matched Synonyms: … 2-Oxopropansäure ... 2-Oxopropionsäure ... 2-ketopropionic acid …
Matched Iupac: … 2-oxopropanoic acid …
Gadoteridol is a macrocyclic nonionic gadolinium that provides contrast enhancement of the brain, spine, and surrounding tissues, resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to disrupt the normal blood-brain barrier.[A263076,A263081,L49871] It was 1 of the 3 macrocyclic gadolinium-based contrast agents (GBCAs)...
Approved
Investigational
Matched Synonyms: … gadolinium 2,2',2''-[10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl]triacetate …
Matched Iupac: … gadolinium(3+) 2-[4,7-bis(carboxylatomethyl)-10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecan-1-yl] …
Matched Description: … [A263076,A263081,L49871] It was 1 of the 3 macrocyclic gadolinium-based contrast agents (GBCAs) that ... FDA in 1992, gadoteridol received additional approval in 2020 for use in pediatric patients less than 2
A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Approved
Illicit
Matched Synonyms: … N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide …
Matched Iupac: … N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide …
Matched Products: … RAPIFEN 0,5 MG/ML 2 ML AMPUL, 5 ADET …
Naratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches.
Approved
Investigational
Matched Synonyms: … N-methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide ... N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide …
Matched Iupac: … N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethane-1-sulfonamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Products: … NARAMIG 2.5 MG FILM TABLET, 2 ADET …
A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Approved
Investigational
Matched Synonyms: … 17β-Estradiol 3-(bis(2-chloroethyl)carbamate) ... Estradiol 3-(N,N-bis(2-chloroethyl)carbamate) …
Matched Iupac: … -1-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl N,N-bis(2- …
Amprenavir is a protease inhibitor used to treat HIV infection.
Approved
Investigational
Matched Synonyms: … (3S)-Tetrahydro-3-furanyl ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl …
Matched Iupac: … (3S)-oxolan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)4-aminobenzenesulfonamido]-1-phenylbutan-2
Cephalexin is the first of the first generation cephalosporins.[A179071,A179074] This antibiotic contains a beta lactam and a dihydrothiazide. Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.[A179083,Label] Cephalexin was approved by the FDA on 4 January 1971.
Approved
Investigational
Vet approved
Matched Synonyms: … (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic ... 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid …
Matched Iupac: … (6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic …
Matched Salts cas: … 23325-78-2 ... 105879-42-3 ... 38932-40-0
Matched Categories: … Heterocyclic Compounds, 2-Ring …
One of the most common symptoms of advanced renal disease is anemia, caused primarily by the inability of the kidney to respond to anemic conditions with a corresponding increase in erythropoietin (EPO) production. The treatment of anemia associated with chronic kidney disease (CKD) has traditionally involved the administration of exogenous...
Approved
Investigational
Matched Synonyms: … N-(5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl)glycine ... Glycine, N-((5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl)carbonyl)- …
Matched Iupac: … 2-{[5-(3-chlorophenyl)-3-hydroxypyridin-2-yl]formamido}acetic acid …
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were...
Approved
Withdrawn
Matched Synonyms: … 2-amino-3-(4-bromobenzoyl)benzeneacetic acid ... [2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid …
Matched Iupac: … 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid …
Matched Salts cas: … 120638-55-3
Matched Categories: … Selective Cyclooxygenase 2 Inhibitors (NSAIDs) …
Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo...
Approved
Matched Synonyms: … (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol ... 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole …
Matched Iupac: … (2-butyl-4-chloro-1-{[2'-(2H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol …
Matched Categories: … Angiotensin 2 Receptor Blocker ... Angiotensin II Type 2 Receptor Blockers …
Matched Products: … ARA 2
Irbesartan is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy.[L7456,L7459] It can also be used as part of a combination product with hydrochlorothiazide for patients not well controlled or not expected to be well controlled on monotherapy. Unlike angiotensin converting enzyme inhibitors, ARBs are not associated...
Approved
Investigational
Matched Synonyms: … 2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one …
Matched Iupac: … 2-butyl-3-{[2'-(2H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4- …
Matched Categories: … Angiotensin 2 Receptor Blocker ... Angiotensin II Type 2 Receptor Blockers …
Nitrofural or nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Nitrofural has also been administered orally in the treatment of trypanosomiasis. Except for topical drug products formulated for dermatologic application, the FDA withdrew its approval...
Approved
Investigational
Vet approved
Withdrawn
Matched Synonyms: … 5-Nitro-2-furaldehyde semicarbazone …
Matched Iupac: … [(E)-[(5-nitrofuran-2-yl)methylidene]amino]urea …
Matched Products: … NITROCIN % 2 MERHEM, 56 G …
Desflurane, or I-653, a a volatile anesthetic that is more rapidly cleared and less metabolized than previous inhaled anesthetics such as methoxyflurane, sevoflurane, enflurane, or isoflurane.[A226390,A39015,A226893]. It was developed in the late 1980s out of a need for a more rapidly acting and rapidly cleared inhaled anesthetic.[A226883,A226888] Desflurane was granted...
Approved
Matched Synonyms: … 1,1,1,2-tetrafluoro-2-(difluoromethoxy)ethane ... (±)-2-difluoromethyl 1,2,2,2-tetrafluoroethyl ether …
Matched Iupac: … 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane …
Displaying drugs 101 - 125 of 12440 in total