Cholinergic Agents

Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of ACETYLCHOLINE, and drugs that affect the survival of cholinergic neurons. The term cholinergic agents is sometimes still used in the narrower sense of MUSCARINIC AGONISTS, although most modern texts discourage that usage.
DrugDrug NameDrug Description
DB00042Botulinum Toxin Type BA purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea.
DB00083Botulinum toxin type AA purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
DB00184NicotineA stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
DB00185CevimelineA muscarinic agonist with parasympathomimetic activities that is used for the symptomatic treatment of dry mouth in patients with Sjögren's Syndrome.
DB00209TrospiumAn antimuscarinic agent used to treat the symptoms of overactive bladder (OAB).
DB00219OxyphenoniumFor the treatment of visceral spasms
DB00245BenzatropineAn anticholinergic drug used to treat Parkinson's disease (PD) and extrapyramidal symptoms, except tardive dyskinesia.
DB00332IpratropiumAn anticholinergic drug used in the control of symptoms related to bronchospasm in chronic obstructive pulmonary disease (COPD).
DB00376TrihexyphenidylAn antispasmodic drug used as an adjunct drug in the management of parkinsonism and as a treatment for extrapyramidal symptoms caused by drugs affecting the central nervous system (CNS).
DB00382TacrineFor the palliative treatment of mild to moderate dementia of the Alzheimer's type.
DB00387ProcyclidineAn antispasmodic drug used to treat parkinsonism of various types and in the treatment of extrapyramidal symptoms.
DB00392ProfenamineAn antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease.
DB00411CarbamoylcholineA direct acting miotic agent administered ophthalmically to decrease intraocular pressure in glaucoma or after eye surgery, and to induce miosis during surgery.
DB00424HyoscyamineFor treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease...
DB00483Gallamine triethiodideA nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation.
DB00496DarifenacinAn M3 muscarinic receptor blocker used to treat urinary incontinence.
DB00517Anisotropine methylbromideFor use in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcer, to reduce further gastric acid secretion and delay gastric emptying.
DB00545PyridostigmineA cholinesterase inhibitor used to treat myasthenia gravis.
DB00572AtropineA muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.
DB00657MecamylamineA nicotine antagonist used to treat moderate to severe essential hypertension and uncomplicated malignant hypertension.
DB00670PirenzepineAn antimuscarinic agent used to treat peptic ulcers, gastric ulcers, and duodenal ulcers.
DB00674GalantamineA benzazepine derivative used to treat mild to moderate dementia associated with Alzheimer's Disease.
DB00677IsoflurophateFor use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
DB00732Atracurium besylateA non-depolarizing neuromuscular blocker used to facilitate endotracheal intubation and relax skeletal muscles during surgery.
DB00733PralidoximeA cholinesterase reactivator used to treat organophosphate poisoning.
DB00747ScopolamineAn anticholinergic used to treat excessive salivation, colicky abdominal pain, bradycardia, diverticulitis, IBS, and motion sickness.
DB00772MalathionA parasympathomimetic organophosphate used to treat head lice.
DB00782PropanthelineAn antimuscarinic agent used to treat urinary incontinence, hyperhidrosis, as well as cramps and spasms of the stomach, intestines, and bladder.
DB00804DicyclomineAn antimuscarinic agent used to treat IBS.
DB00809TropicamideA muscarinic receptor antagonist used to dilate the pupil.
DB00810BiperidenA muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs.
DB00843DonepezilAn acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia.
DB00908QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
DB00940MethanthelineFor the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
DB00944DemecariumFor the topical treatment of chronic open-angle glaucoma.
DB00967DesloratadineA second generation tricyclic antihistamine used to treat seasonal and non seasonal allergic rhinitis, pruritus, and urticaria.
DB00979CyclopentolateAn anticholinergic used to cause mydriasis and cycloplegia for diagnostic testing.
DB00981PhysostigmineA cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity.
DB00986GlycopyrroniumAn anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.
DB00989RivastigmineA cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's.
DB01010EdrophoniumA cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis.
DB01019BethanecholA muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention.
DB01036TolterodineA muscarinic receptor antagonist used to treat overactive bladder with urinary incontinence, urgency, and frequency.
DB01057EchothiophateAn acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.
DB01085PilocarpineA muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy.
DB01090PentoliniumUsed to produce controlled hypotension during surgical procedures and in hypertensive crises.
DB01116TrimethaphanFor the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies.
DB01122AmbenoniumA cholinesterase inhibitor that targets both muscarinic and nicotinic receptors indicated for the treatment of myasthenia gravis.
DB01173OrphenadrineA muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort.
DB01199TubocurarineA neuromuscular blocker used for the diagnosis of and facilitation of intubation after induction of anesthesia during surgical procedures.
DB01273VareniclineA partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation.
DB01337PancuroniumA neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DB01338PipecuroniumA nondepolarizing neuromuscular blocking agent used to relax muscles during anesthesia and surgical procedures.
DB01339VecuroniumA nondepolarizing neuromuscular blocking agent used to relax muscles or as an adjunct in general anesthesia during surgical procedures.
DB01400NeostigmineA cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone.
DB01409TiotropiumA long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD).
DB01591SolifenacinA muscarinic antagonist with antispasmodic properties used to treat urge urinary incontinence, urgency, and urinary frequency associated with an overactive bladder.
DB023651,10-PhenanthrolineNot Available
DB03128AcetylcholineA parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.
DB04365ArecolineAn alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the...
DB04864Huperzine AInvestigated for use/treatment in alzheimer's disease.
DB05137LobelineInvestigated for use/treatment in addictions.
DB05708GTS-21Investigated for use/treatment in alzheimer's disease and schizophrenia and schizoaffective disorders.
DB06702FesoterodineAn antimuscarinic agent used in the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.
DB06709MethacholineA parasympathomimetic bronchoconstrictor used during the bronchial challenge test for the diagnosis of bronchial hyperreactivity in subjects who do not have clinically apparent asthma.
DB07720EpibatidineNot Available
DB08960HexamethoniumA nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been...
DB08997DexetimideA muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
DB09007ChlorphenoxamineChlorphenoxamine is marketed under the name Phenoxene. It is an antihistamine and anticholinergic used to treat itching as well as for its antiparkinsonian effect.
DB09023BenactyzineBenactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety. Benactyzine is no longer widely used in medicine, although it is still a...
DB09300ButylscopolamineAn antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain.
DB11390CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
DB11397DichlorvosDichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products...
DB11412FenthionFenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is...
DB11421ImidaclopridImidacloprid is a neonicotinoid, which is a class of neuro-active insecticides modeled after nicotine. Imidacloprid is a patented chemical, Imidacloprid is manufactured by Bayer Cropscience (part of Bayer AG) and...
DB11473MetrifonateMetrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.
DB12278PropiverineAn antimuscarinic agent used to treat urinary incontinence or increased urinary frequency or urgency.
DB13058Methanesulfonyl FluorideMethanesulfonyl Fluoride has been used in trials studying the treatment of Safety.
DB13295AtracuriumNot Annotated
DB13413PhenglutarimideNot Annotated
DB13495ParaoxonNot Annotated
DB13500OtiloniumNot Annotated
DB13505EmeproniumNot Annotated
DB13584GallamineNot Annotated
DB13619BornaprineNot Annotated
DB13648AlcuroniumA non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.
DB13694DistigmineDistigmine is a parasympathomimetic agent with a longer duration of action and enhanced drug accumulation compared to DB00545 and DB01400. It is an anticholinergic drug and long-acting reversible carbamate cholinesterase...
DB13750ObidoximeNot Annotated
DB01226MivacuriumA short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation.
DB15357XanomelineXanomeline is under investigation in clinical trial NCT02831231 (Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium).
DB00941HexafluroniumUsed as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations.
DB04892PhenserineFor the treatment of Alzheimer's disease (AD).
DB05152NGX267Investigated for use/treatment in alzheimer's disease and schizophrenia and schizoaffective disorders.
DB12482AcotiamideAcotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia.
DB15317PosiphenPosiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease).
DrugDrug NameTargetType
DB00042Botulinum Toxin Type BVesicle-associated membrane protein 1target
DB00042Botulinum Toxin Type BVesicle-associated membrane protein 2target
DB00042Botulinum Toxin Type BSynaptotagmin-2target
DB00083Botulinum toxin type ASynaptosomal-associated protein 25target
DB00083Botulinum toxin type ARho-related GTP-binding protein RhoBtarget
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-2target
DB00184NicotineNeuronal acetylcholine receptor subunit beta-2target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-7target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-4target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-10target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-9target
DB00184NicotineCytochrome P450 2A6enzyme
DB00184NicotineCytochrome P450 2E1enzyme
DB00184NicotineCytochrome P450 2A13enzyme
DB00184NicotineCytochrome P450 2B6enzyme
DB00184NicotineNeuronal acetylcholine receptor subunit beta-4target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-3target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-5target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-6target
DB00184NicotineNeuronal acetylcholine receptor subunit beta-3target
DB00184NicotineSolute carrier family 22 member 2transporter
DB00184NicotineSolute carrier family 22 member 1transporter
DB00184NicotineSolute carrier family 22 member 3transporter
DB00184NicotineSolute carrier family 22 member 5transporter
DB00184NicotineSolute carrier family 22 member 4transporter
DB00184NicotineCytochrome P450 1A1enzyme
DB00184NicotineCytochrome P450 1A2enzyme
DB00184NicotineCytochrome P450 2C19enzyme
DB00184NicotineCytochrome P450 2C8enzyme
DB00184NicotineCytochrome P450 2C9enzyme
DB00184NicotineCytochrome P450 2D6enzyme
DB00184NicotineCytochrome P450 3A4enzyme
DB00184NicotineAmine oxidase [flavin-containing] Aenzyme
DB00184NicotineAmine oxidase [flavin-containing] Benzyme
DB00184NicotineCytochrome P450 19A1target
DB00184NicotineCholine O-acetyltransferasetarget
DB00185CevimelineMuscarinic acetylcholine receptor M1target
DB00185CevimelineMuscarinic acetylcholine receptor M3target
DB00185CevimelineCytochrome P450 3A4enzyme
DB00185CevimelineCytochrome P450 2D6enzyme
DB00185CevimelineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00209TrospiumMuscarinic acetylcholine receptor M1target
DB00209TrospiumCytochrome P450 2D6enzyme
DB00219OxyphenoniumMuscarinic acetylcholine receptor M1target
DB00245BenzatropineMuscarinic acetylcholine receptor M1target
DB00245BenzatropineSodium-dependent dopamine transportertarget
DB00245BenzatropineHistamine H1 receptortarget
DB00245BenzatropineSerum albumincarrier
DB00245BenzatropineSodium-dependent serotonin transportertarget
DB00245BenzatropineSodium-dependent noradrenaline transportertarget
DB00332IpratropiumMuscarinic acetylcholine receptor M1target
DB00332IpratropiumMuscarinic acetylcholine receptor M2target
DB00332IpratropiumMuscarinic acetylcholine receptor M3target
DB00332IpratropiumSolute carrier family 22 member 5transporter
DB00332IpratropiumSolute carrier family 22 member 4transporter
DB00332IpratropiumSerum albumincarrier
DB00332Ipratropiumalpha1-acid glycoproteincarrier
DB00376TrihexyphenidylMuscarinic acetylcholine receptor M1target
DB00376TrihexyphenidylMuscarinic acetylcholine receptor M2target
DB00376TrihexyphenidylMuscarinic acetylcholine receptor M3target
DB00376TrihexyphenidylMuscarinic acetylcholine receptor M4target
DB00376TrihexyphenidylMuscarinic acetylcholine receptor M5target
DB00382TacrineAcetylcholinesterasetarget
DB00382TacrineCytochrome P450 1A2enzyme
DB00382TacrineCholinesterasetarget
DB00382TacrineP-glycoprotein 1transporter
DB00382TacrineLiver carboxylesterase 1target
DB00387ProcyclidineMuscarinic acetylcholine receptor M1target
DB00387ProcyclidineMuscarinic acetylcholine receptor M2target
DB00387ProcyclidineMuscarinic acetylcholine receptor M4target
DB00387ProcyclidineMuscarinic acetylcholine receptor M3target
DB00392ProfenamineGlutamate receptor ionotropic, NMDA 3Atarget
DB00392ProfenamineMuscarinic acetylcholine receptor M1target
DB00392ProfenamineCholinesteraseenzyme
DB00392ProfenamineMuscarinic acetylcholine receptor M2target
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M1target
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M2target
DB00411CarbamoylcholineNeuronal acetylcholine receptor subunit alpha-2target
DB00411CarbamoylcholineCytosolic phospholipase A2enzyme
DB00411CarbamoylcholineAcetylcholinesterasetarget
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M3target
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M4target
DB00424HyoscyamineMuscarinic acetylcholine receptor M1target
DB00424HyoscyamineMuscarinic acetylcholine receptor M2target
DB00424HyoscyamineMuscarinic acetylcholine receptor M3target
DB00424HyoscyamineMuscarinic acetylcholine receptor M4target
DB00483Gallamine triethiodideNeuronal acetylcholine receptor subunit alpha-2target
DB00483Gallamine triethiodideMuscarinic acetylcholine receptor M2target
DB00483Gallamine triethiodideAcetylcholinesterasetarget
DB00483Gallamine triethiodideMuscarinic acetylcholine receptor M1target
DB00483Gallamine triethiodideMuscarinic acetylcholine receptor M5target
DB00496DarifenacinMuscarinic acetylcholine receptor M3target
DB00496DarifenacinCytochrome P450 3A4enzyme
DB00496DarifenacinCytochrome P450 2D6enzyme
DB00496DarifenacinMuscarinic acetylcholine receptor M1target
DB00496DarifenacinMuscarinic acetylcholine receptor M2target
DB00496DarifenacinMuscarinic acetylcholine receptor M4target
DB00496DarifenacinMuscarinic acetylcholine receptor M5target
DB00517Anisotropine methylbromideMuscarinic acetylcholine receptor M1target
DB00517Anisotropine methylbromideMuscarinic acetylcholine receptor M2target
DB00517Anisotropine methylbromideMuscarinic acetylcholine receptor M3target
DB00545PyridostigmineAcetylcholinesterasetarget
DB00545PyridostigmineCholinesterasetarget
DB00545PyridostigmineSerum albumintarget
DB00572AtropineMuscarinic acetylcholine receptor M2target
DB00572AtropineMuscarinic acetylcholine receptor M1target
DB00572AtropineMuscarinic acetylcholine receptor M4target
DB00572AtropineMuscarinic acetylcholine receptor M5target
DB00572AtropineMuscarinic acetylcholine receptor M3target
DB00572AtropineGlycine receptor subunit alpha-1target
DB00572AtropineNeuronal acetylcholine receptor subunit alpha-4target
DB00572AtropineNeuronal acetylcholine receptor subunit beta-2target
DB00572AtropineBile salt export pumptransporter
DB00657MecamylamineNeuronal acetylcholine receptor subunit alpha-2target
DB00657MecamylamineNeuronal acetylcholine receptor subunit alpha-7target
DB00657MecamylamineNeuronal acetylcholine receptor subunit alpha-4target
DB00657MecamylamineNeuronal acetylcholine receptor subunit beta-2target
DB00670PirenzepineMuscarinic acetylcholine receptor M1target
DB00674GalantamineAcetylcholinesterasetarget
DB00674GalantamineCytochrome P450 3A4enzyme
DB00674GalantamineCytochrome P450 2D6enzyme
DB00674GalantamineAcetylcholine receptor subunit alphatarget
DB00674GalantamineAcetylcholine receptor subunit betatarget
DB00674GalantamineAcetylcholine receptor subunit deltatarget
DB00674GalantamineAcetylcholine receptor subunit gammatarget
DB00674GalantamineAcetylcholine receptor subunit epsilontarget
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-2target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-3target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-4target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-5target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-6target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-7target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-9target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-10target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-2target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-3target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-4target
DB00674GalantamineCholinesterasetarget
DB00677IsoflurophateCholinesterasetarget
DB00677IsoflurophateAcetylcholinesterasetarget
DB00677IsoflurophateCholinesteraseenzyme
DB00677IsoflurophateSerum albumincarrier
DB00677IsoflurophateSerotransferrintarget
DB00732Atracurium besylateNeuronal acetylcholine receptor subunit alpha-2target
DB00733PralidoximeAcetylcholinesterasetarget
DB00733PralidoximeCholinesterasetarget
DB00747ScopolamineMuscarinic acetylcholine receptor M1target
DB00747ScopolamineSucrase-isomaltase, intestinaltarget
DB00747ScopolamineMuscarinic acetylcholine receptor M2target
DB00747ScopolamineMuscarinic acetylcholine receptor M3target
DB00747ScopolamineMuscarinic acetylcholine receptor M4target
DB00747ScopolamineMuscarinic acetylcholine receptor M5target
DB00747ScopolamineP-glycoprotein 1transporter
DB00747ScopolamineNeuronal acetylcholine receptor subunit alpha-4target
DB00747ScopolamineNeuronal acetylcholine receptor subunit beta-2target
DB00772MalathionCholinesterasetarget
DB00772MalathionCytochrome P450 1A2enzyme
DB00772MalathionCytochrome P450 2B6enzyme
DB00782PropanthelineMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M2target
DB00809TropicamideMuscarinic acetylcholine receptor M4target
DB00809TropicamideMuscarinic acetylcholine receptor M1target
DB00809TropicamideMuscarinic acetylcholine receptor M2target
DB00809TropicamideMuscarinic acetylcholine receptor M3target
DB00810BiperidenNeuronal acetylcholine receptor subunit alpha-2target
DB00810BiperidenMuscarinic acetylcholine receptor M1target
DB00810BiperidenCytochrome P450 2D6enzyme
DB00843DonepezilAcetylcholinesterasetarget
DB00843Donepezil5-hydroxytryptamine receptor 2Atarget
DB00843DonepezilCytochrome P450 3A4enzyme
DB00843DonepezilCytochrome P450 2D6enzyme
DB00843DonepezilCytochrome P450 2C9enzyme
DB00843DonepezilCholinesterasetarget
DB00843DonepezilNitric oxide synthase, braintarget
DB00843DonepezilTumor necrosis factor-inducible gene 6 proteintarget
DB00843DonepezilInterleukin-1 betatarget
DB00843DonepezilNuclear factor NF-kappa-Btarget
DB00843DonepezilATP-binding cassette sub-family G member 2transporter
DB00843DonepezilP-glycoprotein 1transporter
DB00843DonepezilNMDA receptortarget
DB00908QuinidineSodium channel protein type 5 subunit alphatarget
DB00908QuinidineAlpha-1-acid glycoprotein 1carrier
DB00908QuinidinePotassium voltage-gated channel subfamily H member 2target
DB00908QuinidinePotassium channel subfamily K member 1target
DB00908QuinidinePotassium channel subfamily K member 6target
DB00908QuinidineCytochrome P450 1A2enzyme
DB00908QuinidineCytochrome P450 2E1enzyme
DB00908QuinidineCytochrome P450 1A1enzyme
DB00908QuinidineCytochrome P450 2D6enzyme
DB00908QuinidineCytochrome P450 3A4enzyme
DB00908QuinidineCytochrome P450 3A7enzyme
DB00908QuinidineSolute carrier family 22 member 2transporter
DB00908QuinidineSolute carrier family 22 member 1transporter
DB00908QuinidineSolute carrier family 22 member 5transporter
DB00908QuinidineP-glycoprotein 1transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1A2transporter
DB00908QuinidineSolute carrier family 22 member 8transporter
DB00908QuinidineCanalicular multispecific organic anion transporter 1transporter
DB00908QuinidineSolute carrier family 22 member 4transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1B1transporter
DB00908QuinidineCytochrome P450 2B6enzyme
DB00908QuinidineCytochrome P450 2C9enzyme
DB00908QuinidineAlpha-1A adrenergic receptortarget
DB00908QuinidineAlpha-1B adrenergic receptortarget
DB00908QuinidineAlpha-1D adrenergic receptortarget
DB00908QuinidineBile salt export pumptransporter
DB00908QuinidineCytochrome P450 2C8enzyme
DB00940MethanthelineMuscarinic acetylcholine receptor M1target
DB00940MethanthelineHistamine H2 receptortarget
DB00944DemecariumAcetylcholinesterasetarget
DB00944DemecariumCholinesterasetarget
DB00967DesloratadineHistamine H1 receptortarget
DB00967DesloratadineP-glycoprotein 1transporter
DB00979CyclopentolateMuscarinic acetylcholine receptor M1target
DB00979CyclopentolateCholinesteraseenzyme
DB00981PhysostigmineAcetylcholinesterasetarget
DB00981PhysostigmineNeuronal acetylcholine receptor subunit alpha-4target
DB00981PhysostigmineNeuronal acetylcholine receptor subunit beta-2target
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M1target
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M3target
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M2target
DB00989RivastigmineAcetylcholinesterasetarget
DB00989RivastigmineCholinesterasetarget
DB01010EdrophoniumAcetylcholinesterasetarget
DB01010EdrophoniumCholinesterasetarget
DB01019BethanecholMuscarinic acetylcholine receptor M2target
DB01019BethanecholMuscarinic acetylcholine receptor M1target
DB01019BethanecholMuscarinic acetylcholine receptor M3target
DB01019BethanecholMuscarinic acetylcholine receptor M4target
DB01036TolterodineMuscarinic acetylcholine receptor M1target
DB01036TolterodineMuscarinic acetylcholine receptor M2target
DB01036TolterodineMuscarinic acetylcholine receptor M3target
DB01036TolterodineCytochrome P450 2D6enzyme
DB01036TolterodineCytochrome P450 3A4enzyme
DB01036TolterodineCytochrome P450 2C9enzyme
DB01036TolterodineCytochrome P450 2C19enzyme
DB01036TolterodineMuscarinic acetylcholine receptor M4target
DB01036TolterodineMuscarinic acetylcholine receptor M5target
DB01057EchothiophateCholinesterasetarget
DB01057EchothiophateSerum albumincarrier
DB01085PilocarpineMuscarinic acetylcholine receptor M1target
DB01085PilocarpineMuscarinic acetylcholine receptor M2target
DB01085PilocarpineCytochrome P450 2A6enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M3target
DB01085PilocarpineCytochrome P450 3A4enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M4target
DB01090PentoliniumNeuronal acetylcholine receptor subunit alpha-10target
DB01090PentoliniumNeuronal acetylcholine receptor subunit alpha-3target
DB01090PentoliniumNeuronal acetylcholine receptor subunit beta-4target
DB01116TrimethaphanNeuronal acetylcholine receptor subunit alpha-10target
DB01116TrimethaphanCholinesteraseenzyme
DB01122AmbenoniumAcetylcholinesterasetarget
DB01122AmbenoniumCholinesteraseenzyme
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 1target
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 2Dtarget
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 3Btarget
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 3Atarget
DB01173OrphenadrineHistamine H1 receptortarget
DB01173OrphenadrineCytochrome P450 2B6enzyme
DB01173OrphenadrineCytochrome P450 2E1enzyme
DB01173OrphenadrineCytochrome P450 3A4enzyme
DB01173OrphenadrineSodium-dependent noradrenaline transportertarget
DB01173OrphenadrineSodium channel protein type 10 subunit alphatarget
DB01173OrphenadrineCytochrome P450 1A2enzyme
DB01173OrphenadrineCytochrome P450 2D6enzyme
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
DB01199TubocurarineAcetylcholinesterasetarget
DB01199Tubocurarine5-hydroxytryptamine receptor 3Atarget
DB01199TubocurarineSolute carrier family 22 member 1transporter
DB01199TubocurarineSolute carrier family 22 member 2transporter
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
DB01199TubocurarineCholinesteraseenzyme
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-4target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-7target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-3target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-6target
DB01273VareniclineNeuronal acetylcholine receptor subunit beta-2target
DB01273VareniclineSolute carrier family 22 member 2transporter
DB01337PancuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01337PancuroniumCholinesteraseenzyme
DB01337PancuroniumMuscarinic acetylcholine receptor M2target
DB01337PancuroniumMuscarinic acetylcholine receptor M3target
DB01337PancuroniumSolute carrier family 22 member 1transporter
DB01337PancuroniumSolute carrier family 22 member 2transporter
DB01338PipecuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01338PipecuroniumMuscarinic acetylcholine receptor M2target
DB01338PipecuroniumMuscarinic acetylcholine receptor M3target
DB01338PipecuroniumCholinesteraseenzyme
DB01339VecuroniumP-glycoprotein 1transporter
DB01339VecuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01400NeostigmineAcetylcholinesterasetarget
DB01400NeostigmineCholinesteraseenzyme
DB01409TiotropiumMuscarinic acetylcholine receptor M3target
DB01409TiotropiumCytochrome P450 2D6enzyme
DB01409TiotropiumCytochrome P450 3A4enzyme
DB01409TiotropiumMuscarinic acetylcholine receptor M1target
DB01409TiotropiumMuscarinic acetylcholine receptor M2target
DB01409TiotropiumSolute carrier family 22 member 5transporter
DB01409TiotropiumSolute carrier family 22 member 4transporter
DB01409TiotropiumMuscarinic acetylcholine receptor M4target
DB01409TiotropiumMuscarinic acetylcholine receptor M5target
DB01591SolifenacinMuscarinic acetylcholine receptor M3target
DB01591SolifenacinMuscarinic acetylcholine receptor M1target
DB01591SolifenacinCytochrome P450 3A4enzyme
DB01591SolifenacinMuscarinic acetylcholine receptor M2target
DB01591SolifenacinMuscarinic acetylcholine receptor M4target
DB01591SolifenacinMuscarinic acetylcholine receptor M5target
DB01591Solifenacinalpha1-acid glycoproteincarrier
DB01591SolifenacinCytochrome P450 1A1enzyme
DB01591SolifenacinCytochrome P450 2D6enzyme
DB023651,10-PhenanthrolineMethyl-accepting chemotaxis protein IItarget
DB023651,10-PhenanthrolineMetallo-beta-lactamase L1target
DB03128AcetylcholineAcetylcholinesterasetarget
DB03128AcetylcholineSolute carrier family 22 member 5transporter
DB03128AcetylcholineSolute carrier family 22 member 1transporter
DB03128AcetylcholineMuscarinic acetylcholine receptor M1target
DB03128AcetylcholineMuscarinic acetylcholine receptor M2target
DB03128AcetylcholineMuscarinic acetylcholine receptor M3target
DB03128AcetylcholineMuscarinic acetylcholine receptor M4target
DB03128AcetylcholineNeuronal acetylcholine receptor subunit alpha-7target
DB04365ArecolineMuscarinic acetylcholine receptor M1target
DB04365ArecolineMuscarinic acetylcholine receptor M3target
DB04864Huperzine AAcetylcholinesterasetarget
DB05137LobelineNeuronal acetylcholine receptor subunit alpha-9target
DB05137LobelineNeuronal acetylcholine receptor subunit alpha-10target
DB05137LobelineNeuronal acetylcholine receptor subunit alpha-7target
DB05708GTS-21Neuronal acetylcholine receptor subunit alpha-7target
DB05708GTS-21Cytochrome P450 1A2enzyme
DB05708GTS-21Cytochrome P450 2E1enzyme
DB06702FesoterodineMuscarinic acetylcholine receptor M1target
DB06702FesoterodineMuscarinic acetylcholine receptor M3target
DB06702FesoterodineCytochrome P450 3A4enzyme
DB06702FesoterodineMuscarinic acetylcholine receptor M2target
DB06702FesoterodineMuscarinic acetylcholine receptor M4target
DB06702FesoterodineMuscarinic acetylcholine receptor M5target
DB06702FesoterodineCytochrome P450 2D6enzyme
DB06702FesoterodineP-glycoprotein 1transporter
DB06709MethacholineMuscarinic acetylcholine receptor M3target
DB07720EpibatidineCHRNA7-FAM7A fusion proteintarget
DB07720EpibatidineNeuronal acetylcholine receptor subunit alpha-7target
DB07720EpibatidineNeuronal acetylcholine receptor subunit beta-2target
DB07720EpibatidineNeuronal acetylcholine receptor subunit alpha-2target
DB07720EpibatidineNeuronal acetylcholine receptor subunit alpha-3target
DB07720EpibatidineNeuronal acetylcholine receptor subunit alpha-4target
DB07720EpibatidineNeuronal acetylcholine receptor subunit beta-4target
DB08960HexamethoniumNeuronal acetylcholine receptor subunit alpha-2target
DB09300ButylscopolamineMuscarinic acetylcholine receptor M3target
DB09300ButylscopolamineMuscarinic acetylcholine receptor M2target
DB11397DichlorvosSerum albumincarrier
DB11397DichlorvosSerotransferrintarget
DB11397DichlorvosCholinesterasetarget
DB11421ImidaclopridCHRNA7-FAM7A fusion proteintarget
DB12278PropiverineMuscarinic acetylcholine receptor M1target
DB12278PropiverineMuscarinic acetylcholine receptor M2target
DB12278PropiverineMuscarinic acetylcholine receptor M3target
DB12278PropiverineMuscarinic acetylcholine receptor M4target
DB12278PropiverineMuscarinic acetylcholine receptor M5target
DB12278PropiverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB12278PropiverineAlpha-1A adrenergic receptortarget
DB12278PropiverineCytochrome P450 3A4enzyme
DB12278PropiverineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB12278PropiverineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB13500OtiloniumCytochrome P450 3A4enzyme
DB01226MivacuriumNeuronal acetylcholine receptor subunit alpha-2target
DB01226MivacuriumMuscarinic acetylcholine receptor M2target
DB01226MivacuriumMuscarinic acetylcholine receptor M3target
DB01226MivacuriumCholinesterasetarget
DB00941HexafluroniumCholinesterasetarget
DB04892PhenserineAcetylcholinesterasetarget
DB04892PhenserineCholinesterasetarget
DB04892PhenserineAmyloid beta A4 proteintarget
DB05152NGX267Muscarinic acetylcholine receptor M1target