Identification

Name
Meclizine
Accession Number
DB00737  (APRD00354)
Type
Small Molecule
Groups
Approved
Description

A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. [PubChem]

Structure
Thumb
Synonyms
  • Meclizine
  • Meclozine
  • Nevidoxine
Product Ingredients
IngredientUNIICASInChI Key
Meclizine HydrochlorideHDP7W44CIO31884-77-2BAAVORPTHSKWGJ-UHFFFAOYSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AntivertTablet12.5 mg/1OralRoerig1997-04-11Not applicableUs
AntivertTablet50 mg/1OralRoerig1997-04-11Not applicableUs
AntivertTablet25 mg/1OralRoerig1997-04-11Not applicableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
MeclizineTablet12.5 mg/1OralDirectrx2016-04-28Not applicableUs
Meclizine HydrochlorideTablet25 mg/1OralRemedy Repack2017-04-20Not applicableUs
Meclizine HydrochlorideTablet12.5 mg/1OralAmneal Pharmaceuticals2010-02-12Not applicableUs
Meclizine HydrochlorideTablet25 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs1981-06-03Not applicableUs
Meclizine HydrochlorideTablet12.5 mg/1OralPhysicians Total Care, Inc.1994-07-05Not applicableUs
Meclizine HydrochlorideTablet12.5 mg/1OralNucare Pharmaceuticals, Inc.2012-04-30Not applicableUs
Meclizine HydrochlorideTablet25 mg/1OralRemedy Repack2013-10-082016-11-03Us
Meclizine HydrochlorideTablet25 mg/1OralUnit Dose Services2012-04-30Not applicableUs
Meclizine HydrochlorideTablet25 mg/1OralSt. Marys Medical Park Pharmacy2012-04-30Not applicableUs
Meclizine HydrochlorideTablet25 mg/1OralRemedy Repack2015-01-142017-04-14Us
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BonamineTablet, multilayer, extended release25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Bonamine Tab 25mg ChewableTablet, chewable25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1954-12-312011-08-04Canada
BonineTablet, chewable25 mg/1OralInsight Pharmaceuticals2009-06-08Not applicableUs
BonineTablet, chewable25 mg/1OralWell Spring Pharmaceutical Corporation2017-04-18Not applicableUs
BonineTablet, chewable25 mg/1OralWell Spring Pharmaceutical Corporation2014-12-15Not applicableUs
CVS Motion Sickness Fast MeltingTablet, orally disintegrating25 mg/1OralCVS Health2015-08-27Not applicableUs
Dramamine Less DrowsyTablet25 mg/1OralMedtech Laboratories, Inc.2011-09-01Not applicableUs
Jet-Avert Motion Sickness AidTablet25 mg/1OralBell International Laboratories2017-10-07Not applicableUs
Less Drowsy Formula Motion Sickness ReliefTablet25 mg/1OralSalado Sales, Inc.2002-06-24Not applicableUs
Less Drowsy Motion Sickness ReliefTablet25 mg/1OralDiscount Drug Mart2014-12-01Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Antivert TabMeclizine Hydrochloride (12.5 mg) + Niacin (50 mg)TabletOralPfizer1956-12-312000-01-24Canada
International/Other Brands
Chiclida / Meclicot / Navicalm / Postafen / Sea-Legs
Categories
UNII
3L5TQ84570
CAS number
569-65-3
Weight
Average: 390.948
Monoisotopic: 390.186276581
Chemical Formula
C25H27ClN2
InChI Key
OCJYIGYOJCODJL-UHFFFAOYSA-N
InChI
InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3
IUPAC Name
1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
SMILES
CC1=CC(CN2CCN(CC2)C(C2=CC=CC=C2)C2=CC=C(Cl)C=C2)=CC=C1

Pharmacology

Indication

For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.

Associated Conditions
Pharmacodynamics

Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.

Mechanism of action

Along with its actions as an antagonist at H1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.

TargetActionsOrganism
AHistamine H1 receptor
antagonist
Human
UNuclear receptor subfamily 1 group I member 3
inverse agonist
Human
Absorption

Well absorbed

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Hepatic

Route of elimination
Not Available
Half life

6 hours

Clearance
Not Available
Toxicity

Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Meclizine H1-Antihistamine ActionDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative and stimulatory activities of Meclizine.Experimental, Illicit
2,5-Dimethoxy-4-ethylthioamphetamine2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative and stimulatory activities of Meclizine.Experimental
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative and stimulatory activities of Meclizine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative and stimulatory activities of Meclizine.Experimental, Illicit
4-MethoxyamphetamineThe risk or severity of adverse effects can be increased when Meclizine is combined with 4-Methoxyamphetamine.Experimental, Illicit
5-methoxy-N,N-dimethyltryptamineThe risk or severity of adverse effects can be increased when Meclizine is combined with 5-methoxy-N,N-dimethyltryptamine.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when Meclizine is combined with 7-Nitroindazole.Experimental
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe risk or severity of adverse effects can be increased when Meclizine is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Aceprometazine.Approved
AcetazolamideThe risk or severity of adverse effects can be increased when Meclizine is combined with Acetazolamide.Approved, Vet Approved
AcetophenazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Acetophenazine.Approved
Acetylglycinamide chloral hydrateThe risk or severity of adverse effects can be increased when Meclizine is combined with Acetylglycinamide chloral hydrate.Experimental
AdinazolamThe risk or severity of adverse effects can be increased when Meclizine is combined with Adinazolam.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Meclizine is combined with Adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Meclizine is combined with Agomelatine.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Meclizine is combined with Alaproclate.Experimental
AlcuroniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Alcuronium.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Meclizine is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Meclizine.Approved, Illicit
AlimemazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Alimemazine.Approved, Vet Approved
AllobarbitalThe risk or severity of adverse effects can be increased when Meclizine is combined with Allobarbital.Experimental
AllopregnanoloneThe risk or severity of adverse effects can be increased when Meclizine is combined with Allopregnanolone.Investigational
AlmotriptanThe risk or severity of adverse effects can be increased when Meclizine is combined with Almotriptan.Approved, Investigational
AlosetronThe risk or severity of adverse effects can be increased when Meclizine is combined with Alosetron.Approved, Withdrawn
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Meclizine is combined with Alphacetylmethadol.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Meclizine is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Meclizine.Approved, Illicit, Investigational
AlprenololThe risk or severity of adverse effects can be increased when Meclizine is combined with Alprenolol.Approved, Withdrawn
AlverineThe risk or severity of adverse effects can be increased when Meclizine is combined with Alverine.Approved, Investigational
AmikacinThe risk or severity of adverse effects can be increased when Meclizine is combined with Amikacin.Approved, Investigational, Vet Approved
AmineptineThe risk or severity of adverse effects can be increased when Meclizine is combined with Amineptine.Illicit, Withdrawn
AmisulprideThe risk or severity of adverse effects can be increased when Meclizine is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Meclizine.Approved
AmitriptylinoxideThe risk or severity of adverse effects can be increased when Meclizine is combined with Amitriptylinoxide.Approved, Investigational
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Meclizine.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Meclizine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Meclizine is combined with Amperozide.Experimental
AmphetamineAmphetamine may decrease the sedative and stimulatory activities of Meclizine.Approved, Illicit, Investigational
AniracetamThe risk or severity of adverse effects can be increased when Meclizine is combined with Aniracetam.Experimental
APD791The risk or severity of adverse effects can be increased when Meclizine is combined with APD791.Investigational
ApomorphineThe risk or severity of adverse effects can be increased when Meclizine is combined with Apomorphine.Approved, Investigational
ApramycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Apramycin.Experimental, Vet Approved
AprobarbitalThe risk or severity of adverse effects can be increased when Meclizine is combined with Aprobarbital.Approved, Illicit
ApronalideThe risk or severity of adverse effects can be increased when Meclizine is combined with Apronalide.Experimental
Arbaclofen PlacarbilThe risk or severity of adverse effects can be increased when Meclizine is combined with Arbaclofen Placarbil.Investigational
ArbekacinThe risk or severity of adverse effects can be increased when Meclizine is combined with Arbekacin.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Meclizine.Approved, Investigational
Aripiprazole lauroxilThe risk or severity of adverse effects can be increased when Meclizine is combined with Aripiprazole lauroxil.Approved, Investigational
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Meclizine.Approved
AtomoxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Atomoxetine.Approved
AtracuriumThe risk or severity of adverse effects can be increased when Meclizine is combined with Atracurium.Approved, Experimental, Investigational
Atracurium besylateThe risk or severity of adverse effects can be increased when Meclizine is combined with Atracurium besylate.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Azaperone.Investigational, Vet Approved
AZD-3043The risk or severity of adverse effects can be increased when Meclizine is combined with AZD-3043.Investigational
AzelastineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Meclizine.Approved
BarbexacloneThe risk or severity of adverse effects can be increased when Meclizine is combined with Barbexaclone.Experimental
BarbitalThe risk or severity of adverse effects can be increased when Meclizine is combined with Barbital.Illicit
BeclamideThe risk or severity of adverse effects can be increased when Meclizine is combined with Beclamide.Experimental
BekanamycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Bekanamycin.Experimental
BenactyzineThe risk or severity of adverse effects can be increased when Meclizine is combined with Benactyzine.Withdrawn
BenmoxinThe risk or severity of adverse effects can be increased when Meclizine is combined with Benmoxin.Withdrawn
BenperidolThe risk or severity of adverse effects can be increased when Meclizine is combined with Benperidol.Approved, Investigational
BenzoctamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Benzoctamine.Approved
BenzphetamineBenzphetamine may decrease the sedative and stimulatory activities of Meclizine.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Meclizine is combined with Benzyl alcohol.Approved
Benzylpenicilloyl PolylysineMeclizine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Meclizine.Approved, Investigational
BifemelaneThe risk or severity of adverse effects can be increased when Meclizine is combined with Bifemelane.Experimental
BifeprunoxThe risk or severity of adverse effects can be increased when Meclizine is combined with Bifeprunox.Investigational
BL-1020The risk or severity of adverse effects can be increased when Meclizine is combined with BL-1020.Investigational
BlonanserinThe risk or severity of adverse effects can be increased when Meclizine is combined with Blonanserin.Approved, Investigational
Botulinum Toxin Type AThe risk or severity of adverse effects can be increased when Meclizine is combined with Botulinum Toxin Type A.Approved, Investigational
Botulinum Toxin Type BThe risk or severity of adverse effects can be increased when Meclizine is combined with Botulinum Toxin Type B.Approved, Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Meclizine is combined with Brexpiprazole.Approved, Investigational
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved
BrivaracetamThe risk or severity of adverse effects can be increased when Meclizine is combined with Brivaracetam.Approved, Investigational
BrofaromineThe risk or severity of adverse effects can be increased when Meclizine is combined with Brofaromine.Experimental
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Meclizine.Approved, Illicit, Investigational
BromisovalThe risk or severity of adverse effects can be increased when Meclizine is combined with Bromisoval.Experimental
BromocriptineThe risk or severity of adverse effects can be increased when Meclizine is combined with Bromocriptine.Approved, Investigational
BromperidolThe risk or severity of adverse effects can be increased when Meclizine is combined with Bromperidol.Approved, Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Meclizine is combined with Brotizolam.Approved, Investigational, Withdrawn
BufotenineThe risk or severity of adverse effects can be increased when Meclizine is combined with Bufotenine.Experimental, Illicit
BuprenorphineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe risk or severity of adverse effects can be increased when Meclizine is combined with Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Meclizine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Meclizine.Approved, Illicit
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Meclizine.Approved, Illicit
ButaperazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Butaperazine.Experimental
ButethalThe risk or severity of adverse effects can be increased when Meclizine is combined with Butethal.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Meclizine.Approved, Illicit, Vet Approved
ButriptylineThe risk or severity of adverse effects can be increased when Meclizine is combined with Butriptyline.Approved
CabergolineThe risk or severity of adverse effects can be increased when Meclizine is combined with Cabergoline.Approved
CamazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Camazepam.Approved, Illicit
CannabidiolThe risk or severity of adverse effects can be increased when Meclizine is combined with Cannabidiol.Approved, Investigational
CannabidivarinThe risk or severity of adverse effects can be increased when Meclizine is combined with Cannabidivarin.Investigational
CapreomycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Capreomycin.Approved
CaptodiameThe risk or severity of adverse effects can be increased when Meclizine is combined with Captodiame.Approved, Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Meclizine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Carbinoxamine.Approved
CarbromalThe risk or severity of adverse effects can be increased when Meclizine is combined with Carbromal.Experimental
CarfentanilThe risk or severity of adverse effects can be increased when Meclizine is combined with Carfentanil.Illicit, Investigational, Vet Approved
CariprazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Cariprazine.Approved, Investigational
CarisbamateThe risk or severity of adverse effects can be increased when Meclizine is combined with Carisbamate.Investigational
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Meclizine.Approved
CaroxazoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Caroxazone.Withdrawn
CathinoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Cathinone.Illicit
CerlapirdineThe risk or severity of adverse effects can be increased when Meclizine is combined with Cerlapirdine.Investigational
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Meclizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Meclizine is combined with Chloral hydrate.Approved, Illicit, Investigational, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Meclizine.Approved, Illicit, Investigational
ChlormezanoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Chlormezanone.Approved, Investigational, Withdrawn
ChloroquineThe risk or severity of adverse effects can be increased when Meclizine is combined with Chloroquine.Approved, Investigational, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Chlorphenamine.Approved
ChlorphenesinThe risk or severity of adverse effects can be increased when Meclizine is combined with Chlorphenesin.Approved, Vet Approved, Withdrawn
ChlorphentermineChlorphentermine may decrease the sedative and stimulatory activities of Meclizine.Illicit, Withdrawn
ChlorproethazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Chlorproethazine.Experimental
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Meclizine.Approved, Investigational, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Meclizine is combined with Chlorprothixene.Approved, Investigational, Withdrawn
ChlortetracyclineThe risk or severity of adverse effects can be increased when Meclizine is combined with Chlortetracycline.Approved, Investigational, Vet Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Meclizine.Approved
CilansetronThe risk or severity of adverse effects can be increased when Meclizine is combined with Cilansetron.Investigational
CinitaprideThe risk or severity of adverse effects can be increased when Meclizine is combined with Cinitapride.Approved, Investigational
CinolazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Cinolazepam.Approved
CisaprideThe risk or severity of adverse effects can be increased when Meclizine is combined with Cisapride.Approved, Investigational, Withdrawn
CisatracuriumThe risk or severity of adverse effects can be increased when Meclizine is combined with Cisatracurium.Approved
CitalopramThe risk or severity of adverse effects can be increased when Meclizine is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Meclizine.Approved, Investigational
ClidiniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Clidinium.Approved
ClindamycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Clindamycin.Approved, Vet Approved
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Meclizine.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Meclizine is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Clomipramine.Approved, Investigational, Vet Approved
ClomocyclineThe risk or severity of adverse effects can be increased when Meclizine is combined with Clomocycline.Approved
ClonazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Meclizine.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Meclizine is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Meclizine.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Meclizine is combined with Clothiapine.Experimental
ClotiazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Clotiazepam.Approved, Illicit
CloxazolamThe risk or severity of adverse effects can be increased when Meclizine is combined with Cloxazolam.Approved, Investigational
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Meclizine.Approved
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Meclizine.Approved, Illicit
ColistimethateThe risk or severity of adverse effects can be increased when Meclizine is combined with Colistimethate.Approved, Vet Approved
ColistinThe risk or severity of adverse effects can be increased when Meclizine is combined with Colistin.Approved
CyamemazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Cyamemazine.Approved
CyclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Cyclizine.Approved
CyclobarbitalThe risk or severity of adverse effects can be increased when Meclizine is combined with Cyclobarbital.Experimental
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Meclizine.Approved
CyclopropaneThe risk or severity of adverse effects can be increased when Meclizine is combined with Cyclopropane.Experimental
CyclosporineThe risk or severity of adverse effects can be increased when Meclizine is combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Meclizine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Meclizine is combined with Dantrolene.Approved, Investigational
DapiprazoleThe risk or severity of adverse effects can be increased when Meclizine is combined with Dapiprazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dapoxetine.Investigational
DeanolThe risk or severity of adverse effects can be increased when Meclizine is combined with Deanol.Experimental
DecamethoniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Decamethonium.Approved
DelorazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Delorazepam.Approved, Illicit, Investigational
DemeclocyclineThe risk or severity of adverse effects can be increased when Meclizine is combined with Demeclocycline.Approved
DeramciclaneThe risk or severity of adverse effects can be increased when Meclizine is combined with Deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Meclizine.Approved
DesipramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Desipramine.Approved, Investigational
DesloratadineThe risk or severity of adverse effects can be increased when Meclizine is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Meclizine is combined with Desvenlafaxine.Approved, Investigational
DetomidineThe risk or severity of adverse effects can be increased when Meclizine is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Meclizine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dexmedetomidine.Approved, Vet Approved
DexmethylphenidateThe risk or severity of adverse effects can be increased when Meclizine is combined with Dexmethylphenidate.Approved, Investigational
DextofisopamThe risk or severity of adverse effects can be increased when Meclizine is combined with Dextofisopam.Investigational
DextroamphetamineDextroamphetamine may decrease the sedative and stimulatory activities of Meclizine.Approved, Illicit
DextromethorphanThe risk or severity of adverse effects can be increased when Meclizine is combined with Dextromethorphan.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Meclizine is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Meclizine is combined with Dextropropoxyphene.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dezocine.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Meclizine.Approved, Illicit, Investigational, Vet Approved
DibekacinThe risk or severity of adverse effects can be increased when Meclizine is combined with Dibekacin.Experimental
DibenzepinThe risk or severity of adverse effects can be increased when Meclizine is combined with Dibenzepin.Experimental
DichloralphenazoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Dichloralphenazone.Approved, Illicit
Diethyl etherThe risk or severity of adverse effects can be increased when Meclizine is combined with Diethyl ether.Experimental
DiethylpropionDiethylpropion may decrease the sedative and stimulatory activities of Meclizine.Approved, Illicit
DifenoxinThe risk or severity of adverse effects can be increased when Meclizine is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Meclizine.Approved, Illicit
DihydroergotamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dihydroergotamine.Approved, Investigational
DihydroetorphineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dihydromorphine.Experimental, Illicit
DihydrostreptomycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Dihydrostreptomycin.Investigational, Vet Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Meclizine is combined with Dimenhydrinate.Approved
DimetacrineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dimetacrine.Approved, Withdrawn
DimethyltryptamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dimethyltryptamine.Experimental, Illicit
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Meclizine.Approved, Investigational
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Meclizine.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dixyrazine.Experimental
DolasetronThe risk or severity of adverse effects can be increased when Meclizine is combined with Dolasetron.Approved, Investigational
Domoic AcidThe risk or severity of adverse effects can be increased when Meclizine is combined with Domoic Acid.Experimental
DonepezilThe risk or severity of adverse effects can be increased when Meclizine is combined with Donepezil.Approved
DopamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dopamine.Approved
DoramectinThe risk or severity of adverse effects can be increased when Meclizine is combined with Doramectin.Vet Approved
DosulepinThe risk or severity of adverse effects can be increased when Meclizine is combined with Dosulepin.Approved
DotarizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dotarizine.Investigational
DoxacuriumThe risk or severity of adverse effects can be increased when Meclizine is combined with Doxacurium.Approved
DoxefazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Doxefazepam.Experimental
DoxepinThe risk or severity of adverse effects can be increased when Meclizine is combined with Doxepin.Approved, Investigational
DoxycyclineThe risk or severity of adverse effects can be increased when Meclizine is combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Meclizine is combined with DPDPE.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Meclizine is combined with Drotebanol.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dyclonine.Approved
EcopipamThe risk or severity of adverse effects can be increased when Meclizine is combined with Ecopipam.Investigational
EdivoxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Edivoxetine.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Meclizine.Approved, Investigational
EletriptanThe risk or severity of adverse effects can be increased when Meclizine is combined with Eletriptan.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Meclizine is combined with Eltanolone.Investigational
EltoprazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Eltoprazine.Investigational
EmeproniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Emepronium.Experimental
EmylcamateThe risk or severity of adverse effects can be increased when Meclizine is combined with Emylcamate.Experimental
EnfluraneThe risk or severity of adverse effects can be increased when Meclizine is combined with Enflurane.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Meclizine.Approved, Investigational
EperisoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Eperisone.Approved, Investigational
EpinastineThe risk or severity of adverse effects can be increased when Meclizine is combined with Epinastine.Approved, Investigational
EplivanserinThe risk or severity of adverse effects can be increased when Meclizine is combined with Eplivanserin.Investigational
Ergoloid mesylateThe risk or severity of adverse effects can be increased when Meclizine is combined with Ergoloid mesylate.Approved
ErgonovineThe risk or severity of adverse effects can be increased when Meclizine is combined with Ergonovine.Approved
ErgotamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Ergotamine.Approved
EscitalopramThe risk or severity of adverse effects can be increased when Meclizine is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe risk or severity of adverse effects can be increased when Meclizine is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe risk or severity of adverse effects can be increased when Meclizine is combined with Esmirtazapine.Investigational
EsreboxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Esreboxetine.Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Meclizine.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Meclizine.Approved, Investigational
Etacrynic acidThe risk or severity of adverse effects can be increased when Meclizine is combined with Etacrynic acid.Approved, Investigational
EthadioneThe risk or severity of adverse effects can be increased when Meclizine is combined with Ethadione.Experimental
EthanolMeclizine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Meclizine is combined with Ethchlorvynol.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Meclizine.Approved
EthotoinThe risk or severity of adverse effects can be increased when Meclizine is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Meclizine is combined with Ethyl carbamate.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Meclizine is combined with Ethyl chloride.Approved, Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Meclizine is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Meclizine is combined with Ethylmorphine.Approved, Illicit
EtifoxineThe risk or severity of adverse effects can be increased when Meclizine is combined with Etifoxine.Investigational, Withdrawn
EtiracetamThe risk or severity of adverse effects can be increased when Meclizine is combined with Etiracetam.Investigational
EtizolamThe risk or severity of adverse effects can be increased when Meclizine is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Meclizine is combined with Etomidate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Meclizine is combined with Etorphine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Meclizine is combined with Ezogabine.Approved, Investigational
FabomotizoleThe risk or severity of adverse effects can be increased when Meclizine is combined with Fabomotizole.Experimental
Fazadinium bromideThe risk or severity of adverse effects can be increased when Meclizine is combined with Fazadinium bromide.Experimental
FebarbamateThe risk or severity of adverse effects can be increased when Meclizine is combined with Febarbamate.Experimental
FelbamateThe risk or severity of adverse effects can be increased when Meclizine is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Fencamfamine.Approved, Illicit, Withdrawn
FenfluramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Fenfluramine.Approved, Illicit, Investigational, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Meclizine.Approved, Illicit, Investigational, Vet Approved
FenyramidolThe risk or severity of adverse effects can be increased when Meclizine is combined with Fenyramidol.Experimental
FexofenadineThe risk or severity of adverse effects can be increased when Meclizine is combined with Fexofenadine.Approved, Investigational
FlibanserinThe risk or severity of adverse effects can be increased when Meclizine is combined with Flibanserin.Approved, Investigational
FluanisoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Flunitrazepam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Meclizine.Approved, Investigational, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Meclizine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Meclizine.Approved, Illicit, Investigational
FluspirileneThe risk or severity of adverse effects can be increased when Meclizine is combined with Fluspirilene.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Meclizine.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Fluvoxamine.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Meclizine is combined with Fosphenytoin.Approved, Investigational
FospropofolThe risk or severity of adverse effects can be increased when Meclizine is combined with Fospropofol.Approved, Illicit, Investigational
FramycetinThe risk or severity of adverse effects can be increased when Meclizine is combined with Framycetin.Approved
FrovatriptanThe risk or severity of adverse effects can be increased when Meclizine is combined with Frovatriptan.Approved, Investigational
FurazolidoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Furazolidone.Approved, Investigational, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Meclizine.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Meclizine is combined with Gabapentin Enacarbil.Approved, Investigational
GaboxadolThe risk or severity of adverse effects can be increased when Meclizine is combined with Gaboxadol.Investigational
GallamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Gallamine.Experimental
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Meclizine is combined with Gallamine Triethiodide.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Meclizine.Approved, Illicit, Investigational
Gantacurium ChlorideThe risk or severity of adverse effects can be increased when Meclizine is combined with Gantacurium Chloride.Investigational
GedocarnilThe risk or severity of adverse effects can be increased when Meclizine is combined with Gedocarnil.Experimental
GeneticinThe risk or severity of adverse effects can be increased when Meclizine is combined with Geneticin.Experimental
GentamicinThe risk or severity of adverse effects can be increased when Meclizine is combined with Gentamicin.Approved, Vet Approved
GENTAMICIN C1AThe risk or severity of adverse effects can be increased when Meclizine is combined with GENTAMICIN C1A.Experimental
GepefrineGepefrine may decrease the sedative and stimulatory activities of Meclizine.Experimental
GepironeThe risk or severity of adverse effects can be increased when Meclizine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Meclizine is combined with Glutethimide.Approved, Illicit
GranisetronThe risk or severity of adverse effects can be increased when Meclizine is combined with Granisetron.Approved, Investigational
GuanfacineThe risk or severity of adverse effects can be increased when Meclizine is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Halazepam.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Meclizine.Approved
HalothaneThe risk or severity of adverse effects can be increased when Meclizine is combined with Halothane.Approved, Vet Approved
HarmalineThe risk or severity of adverse effects can be increased when Meclizine is combined with Harmaline.Experimental
HeptabarbitalThe risk or severity of adverse effects can be increased when Meclizine is combined with Heptabarbital.Approved
HeroinThe risk or severity of adverse effects can be increased when Meclizine is combined with Heroin.Approved, Illicit, Investigational
HexafluroniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Hexafluronium.Approved
HexamethoniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Hexamethonium.Experimental
HexapropymateThe risk or severity of adverse effects can be increased when Meclizine is combined with Hexapropymate.Experimental
HexobarbitalThe risk or severity of adverse effects can be increased when Meclizine is combined with Hexobarbital.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Meclizine.Approved, Investigational
HydracarbazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Hydracarbazine.Experimental
HydrocodoneMeclizine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Meclizine.Approved, Illicit
HydroxyamphetamineHydroxyamphetamine may decrease the sedative and stimulatory activities of Meclizine.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved
Hygromycin BThe risk or severity of adverse effects can be increased when Meclizine is combined with Hygromycin B.Vet Approved
HypericinThe risk or severity of adverse effects can be increased when Meclizine is combined with Hypericin.Investigational
IdalopirdineThe risk or severity of adverse effects can be increased when Meclizine is combined with Idalopirdine.Investigational
IfenprodilThe risk or severity of adverse effects can be increased when Meclizine is combined with Ifenprodil.Approved, Investigational, Withdrawn
IferanserinThe risk or severity of adverse effects can be increased when Meclizine is combined with Iferanserin.Investigational
IloperidoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Iloperidone.Approved
ImagabalinThe risk or severity of adverse effects can be increased when Meclizine is combined with Imagabalin.Investigational
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Meclizine.Approved
Imipramine oxideThe risk or severity of adverse effects can be increased when Meclizine is combined with Imipramine oxide.Experimental
IndalpineThe risk or severity of adverse effects can be increased when Meclizine is combined with Indalpine.Investigational, Withdrawn
IndiplonThe risk or severity of adverse effects can be increased when Meclizine is combined with Indiplon.Investigational
Iofetamine I-123Iofetamine I-123 may decrease the sedative and stimulatory activities of Meclizine.Approved
IprazochromeThe risk or severity of adverse effects can be increased when Meclizine is combined with Iprazochrome.Experimental
IprindoleThe risk or severity of adverse effects can be increased when Meclizine is combined with Iprindole.Experimental
IproclozideThe risk or severity of adverse effects can be increased when Meclizine is combined with Iproclozide.Withdrawn
IproniazidThe risk or severity of adverse effects can be increased when Meclizine is combined with Iproniazid.Withdrawn
IsepamicinThe risk or severity of adverse effects can be increased when Meclizine is combined with Isepamicin.Experimental
IsocarboxazidThe risk or severity of adverse effects can be increased when Meclizine is combined with Isocarboxazid.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Meclizine.Approved, Vet Approved
KanamycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Kanamycin.Approved, Investigational, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Meclizine.Approved, Vet Approved
KetanserinThe risk or severity of adverse effects can be increased when Meclizine is combined with Ketanserin.Investigational
KetazolamThe risk or severity of adverse effects can be increased when Meclizine is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Ketobemidone.Approved, Investigational
L-TryptophanThe risk or severity of adverse effects can be increased when Meclizine is combined with L-Tryptophan.Approved, Nutraceutical, Withdrawn
LacosamideThe risk or severity of adverse effects can be increased when Meclizine is combined with Lacosamide.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Meclizine.Approved, Investigational
LanicemineThe risk or severity of adverse effects can be increased when Meclizine is combined with Lanicemine.Investigational
LasmiditanThe risk or severity of adverse effects can be increased when Meclizine is combined with Lasmiditan.Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Meclizine is combined with Levetiracetam.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Meclizine is combined with Levocabastine.Approved, Investigational
LevocetirizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Meclizine is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Meclizine is combined with Levomethadyl Acetate.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Meclizine is combined with Levomilnacipran.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Meclizine.Approved
LincomycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Lincomycin.Approved, Vet Approved
LinezolidThe risk or severity of adverse effects can be increased when Meclizine is combined with Linezolid.Approved, Investigational
LisdexamfetamineLisdexamfetamine may decrease the sedative and stimulatory activities of Meclizine.Approved, Investigational
LisurideThe risk or severity of adverse effects can be increased when Meclizine is combined with Lisuride.Approved, Investigational
Lithium carbonateThe risk or severity of adverse effects can be increased when Meclizine is combined with Lithium carbonate.Approved
Lithium cationThe risk or severity of adverse effects can be increased when Meclizine is combined with Lithium cation.Experimental
LofentanilThe risk or severity of adverse effects can be increased when Meclizine is combined with Lofentanil.Illicit
LofepramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Lofepramine.Experimental
LofexidineThe therapeutic efficacy of Meclizine can be increased when used in combination with Lofexidine.Approved, Investigational
LoprazolamThe risk or severity of adverse effects can be increased when Meclizine is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Meclizine.Approved, Investigational
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Meclizine.Approved
LorcaserinThe risk or severity of adverse effects can be increased when Meclizine is combined with Lorcaserin.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Lormetazepam.Approved
LorpiprazoleThe risk or severity of adverse effects can be increased when Meclizine is combined with Lorpiprazole.Approved
LortalamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Lortalamine.Experimental
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Meclizine.Approved
LumateperoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Lumateperone.Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Meclizine.Approved, Investigational
LymecyclineThe risk or severity of adverse effects can be increased when Meclizine is combined with Lymecycline.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Meclizine is combined with Lysergic Acid Diethylamide.Illicit, Investigational, Withdrawn
m-ChlorophenylpiperazineThe risk or severity of adverse effects can be increased when Meclizine is combined with m-Chlorophenylpiperazine.Investigational
Magnesium acetateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium acetate.Approved
Magnesium acetate tetrahydrateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium acetate tetrahydrate.Approved
Magnesium Aluminum SilicateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium Aluminum Silicate.Approved
Magnesium aspartateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium aspartate.Experimental
Magnesium carbonateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium carbonate.Approved, Investigational
Magnesium cationThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium cation.Approved, Nutraceutical
Magnesium chlorideThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium chloride.Approved
Magnesium citrateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium citrate.Approved
Magnesium gluconateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium gluconate.Approved, Investigational
Magnesium glycinateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium glycinate.Approved
Magnesium hydroxideThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium hydroxide.Approved, Investigational
Magnesium orotateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium orotate.Experimental
Magnesium oxideThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium oxide.Approved
Magnesium phosphateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium phosphate.Experimental
Magnesium silicateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium silicate.Approved
Magnesium stearateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium stearate.Investigational
Magnesium sulfateThe therapeutic efficacy of Meclizine can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
Magnesium TrisilicateThe risk or severity of adverse effects can be increased when Meclizine is combined with Magnesium Trisilicate.Approved
MaprotilineThe risk or severity of adverse effects can be increased when Meclizine is combined with Maprotiline.Approved, Investigational
MazindolThe risk or severity of adverse effects can be increased when Meclizine is combined with Mazindol.Approved, Investigational
MebanazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Mebanazine.Withdrawn
MebicarThe risk or severity of adverse effects can be increased when Meclizine is combined with Mebicar.Experimental
MebutamateThe risk or severity of adverse effects can be increased when Meclizine is combined with Mebutamate.Approved
MecamylamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Mecamylamine.Approved, Investigational
MedazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Meclizine is combined with Medetomidine.Vet Approved
MedifoxamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Medifoxamine.Experimental
MelatoninThe risk or severity of adverse effects can be increased when Meclizine is combined with Melatonin.Approved, Nutraceutical, Vet Approved
MelitracenThe risk or severity of adverse effects can be increased when Meclizine is combined with Melitracen.Experimental, Investigational
MelperoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Melperone.Approved, Investigational
MephedroneMephedrone may decrease the sedative and stimulatory activities of Meclizine.Investigational
MephenesinThe risk or severity of adverse effects can be increased when Meclizine is combined with Mephenesin.Approved
MephenoxaloneThe risk or severity of adverse effects can be increased when Meclizine is combined with Mephenoxalone.Experimental
MephentermineMephentermine may decrease the sedative and stimulatory activities of Meclizine.Approved
MephenytoinThe risk or severity of adverse effects can be increased when Meclizine is combined with Mephenytoin.Investigational, Withdrawn
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Meclizine.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Meclizine is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Mesoridazine.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Meclizine.Approved
MetergolineThe risk or severity of adverse effects can be increased when Meclizine is combined with Metergoline.Experimental
MethacyclineThe risk or severity of adverse effects can be increased when Meclizine is combined with Methacycline.Approved, Investigational
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Meclizine.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Meclizine is combined with Methadyl Acetate.Approved, Illicit
MethamphetamineMethamphetamine may decrease the sedative and stimulatory activities of Meclizine.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Meclizine is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Methaqualone.Illicit, Withdrawn
MetharbitalThe risk or severity of adverse effects can be increased when Meclizine is combined with Metharbital.Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Meclizine.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Meclizine.Approved
MethotrimeprazineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved, Investigational
MethoxyfluraneThe risk or severity of adverse effects can be increased when Meclizine is combined with Methoxyflurane.Approved, Investigational, Vet Approved
MethoxyphenamineMethoxyphenamine may decrease the sedative and stimulatory activities of Meclizine.Experimental
MethsuximideThe risk or severity of adverse effects can be increased when Meclizine is combined with Methsuximide.Approved
Methylene blueThe risk or severity of adverse effects can be increased when Meclizine is combined with Methylene blue.Approved, Investigational
MethylpentynolThe risk or severity of adverse effects can be increased when Meclizine is combined with Methylpentynol.Experimental
MethylphenidateThe risk or severity of adverse effects can be increased when Meclizine is combined with Methylphenidate.Approved, Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Meclizine is combined with Methylphenobarbital.Approved
MethyprylonThe risk or severity of adverse effects can be increased when Meclizine is combined with Methyprylon.Approved, Illicit, Withdrawn
MethysergideThe risk or severity of adverse effects can be increased when Meclizine is combined with Methysergide.Approved
MetocurineThe risk or severity of adverse effects can be increased when Meclizine is combined with Metocurine.Approved
Metocurine IodideThe risk or severity of adverse effects can be increased when Meclizine is combined with Metocurine Iodide.Approved, Withdrawn
MetyrosineMeclizine may increase the sedative activities of Metyrosine.Approved
MianserinThe risk or severity of adverse effects can be increased when Meclizine is combined with Mianserin.Approved, Investigational
MicronomicinThe risk or severity of adverse effects can be increased when Meclizine is combined with Micronomicin.Experimental
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Meclizine.Approved, Illicit
MidomafetamineMidomafetamine may decrease the sedative and stimulatory activities of Meclizine.Experimental, Illicit, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Meclizine is combined with Milnacipran.Approved, Investigational
MinaprineThe risk or severity of adverse effects can be increased when Meclizine is combined with Minaprine.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved, Investigational
MirtazapineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MivacuriumThe risk or severity of adverse effects can be increased when Meclizine is combined with Mivacurium.Approved
MK-212The risk or severity of adverse effects can be increased when Meclizine is combined with MK-212.Investigational
MMDAMMDA may decrease the sedative and stimulatory activities of Meclizine.Experimental, Illicit
MoclobemideThe risk or severity of adverse effects can be increased when Meclizine is combined with Moclobemide.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Molindone.Approved
MoperoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Moperone.Experimental
MoricizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Moricizine.Approved, Investigational, Withdrawn
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Meclizine.Approved, Investigational
MosapramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Mosapramine.Experimental
MosaprideThe risk or severity of adverse effects can be increased when Meclizine is combined with Mosapride.Investigational
MRK-409The risk or severity of adverse effects can be increased when Meclizine is combined with MRK-409.Experimental
N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamineThe risk or severity of adverse effects can be increased when Meclizine is combined with N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine.Experimental
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved, Investigational
NaftidrofurylThe risk or severity of adverse effects can be increased when Meclizine is combined with Naftidrofuryl.Experimental
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Meclizine.Approved
NaluzotanThe risk or severity of adverse effects can be increased when Meclizine is combined with Naluzotan.Investigational
NaratriptanThe risk or severity of adverse effects can be increased when Meclizine is combined with Naratriptan.Approved, Investigational
NaronaprideThe risk or severity of adverse effects can be increased when Meclizine is combined with Naronapride.Investigational
NeamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Neamine.Experimental
NefazodoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Nefazodone.Approved, Withdrawn
NefiracetamThe risk or severity of adverse effects can be increased when Meclizine is combined with Nefiracetam.Investigational
NeocitrullamonThe risk or severity of adverse effects can be increased when Meclizine is combined with Neocitrullamon.Experimental
NeomycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Neomycin.Approved, Vet Approved
NeosaxitoxinThe risk or severity of adverse effects can be increased when Meclizine is combined with Neosaxitoxin.Investigational
NetilmicinThe risk or severity of adverse effects can be increased when Meclizine is combined with Netilmicin.Approved, Investigational
NialamideThe risk or severity of adverse effects can be increased when Meclizine is combined with Nialamide.Withdrawn
NiaprazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Niaprazine.Experimental
NisoxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Nisoxetine.Experimental
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Meclizine.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Meclizine.Approved, Vet Approved
NomifensineThe risk or severity of adverse effects can be increased when Meclizine is combined with Nomifensine.Withdrawn
NordazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Nordazepam.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Meclizine.Approved
OctamoxinThe risk or severity of adverse effects can be increased when Meclizine is combined with Octamoxin.Withdrawn
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Meclizine.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Meclizine is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Meclizine is combined with Ondansetron.Approved
OpipramolThe risk or severity of adverse effects can be increased when Meclizine is combined with Opipramol.Investigational
OpiumThe risk or severity of adverse effects can be increased when Meclizine is combined with Opium.Approved, Illicit
OrphenadrineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OrvepitantThe risk or severity of adverse effects can be increased when Meclizine is combined with Orvepitant.Investigational
OsanetantThe risk or severity of adverse effects can be increased when Meclizine is combined with Osanetant.Investigational
OxaflozaneThe risk or severity of adverse effects can be increased when Meclizine is combined with Oxaflozane.Experimental
OxaprotilineThe risk or severity of adverse effects can be increased when Meclizine is combined with Oxaprotiline.Experimental
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Meclizine.Approved
OxcarbazepineThe risk or severity of adverse effects can be increased when Meclizine is combined with Oxcarbazepine.Approved
OxiracetamThe risk or severity of adverse effects can be increased when Meclizine is combined with Oxiracetam.Experimental
OxitriptanThe risk or severity of adverse effects can be increased when Meclizine is combined with Oxitriptan.Approved, Investigational, Nutraceutical
OxprenololThe risk or severity of adverse effects can be increased when Meclizine is combined with Oxprenolol.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Meclizine.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Meclizine.Approved, Investigational, Vet Approved
OxypertineThe risk or severity of adverse effects can be increased when Meclizine is combined with Oxypertine.Experimental
OxytetracyclineThe risk or severity of adverse effects can be increased when Meclizine is combined with Oxytetracycline.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Meclizine.Approved
PalonosetronThe risk or severity of adverse effects can be increased when Meclizine is combined with Palonosetron.Approved, Investigational
PancuroniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Pancuronium.Approved
ParaldehydeMeclizine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParamethadioneThe risk or severity of adverse effects can be increased when Meclizine is combined with Paramethadione.Approved
PargylineThe risk or severity of adverse effects can be increased when Meclizine is combined with Pargyline.Approved
ParomomycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Paromomycin.Approved, Investigational
ParoxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Paroxetine.Approved, Investigational
PenbutololThe risk or severity of adverse effects can be increased when Meclizine is combined with Penbutolol.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Meclizine is combined with Penfluridol.Experimental
PenimepicyclineThe risk or severity of adverse effects can be increased when Meclizine is combined with Penimepicycline.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Meclizine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Meclizine.Approved, Investigational, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved
PerazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Perazine.Approved, Investigational
PergolideThe risk or severity of adverse effects can be increased when Meclizine is combined with Pergolide.Approved, Investigational, Vet Approved, Withdrawn
PerospironeThe risk or severity of adverse effects can be increased when Meclizine is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Meclizine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Meclizine.Approved
PhenacemideThe risk or severity of adverse effects can be increased when Meclizine is combined with Phenacemide.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Meclizine is combined with Phenazocine.Experimental
PhencyclidineThe risk or severity of adverse effects can be increased when Meclizine is combined with Phencyclidine.Illicit
PhenelzineThe risk or severity of adverse effects can be increased when Meclizine is combined with Phenelzine.Approved
PhenethylamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Phenethylamine.Experimental
PheneturideThe risk or severity of adverse effects can be increased when Meclizine is combined with Pheneturide.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Meclizine is combined with Phenibut.Experimental
PheniprazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Pheniprazine.Withdrawn
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Meclizine.Approved, Investigational
PhenoperidineThe risk or severity of adverse effects can be increased when Meclizine is combined with Phenoperidine.Experimental
PhenoxypropazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Phenoxypropazine.Withdrawn
PhenprobamateThe risk or severity of adverse effects can be increased when Meclizine is combined with Phenprobamate.Experimental
PhensuximideThe risk or severity of adverse effects can be increased when Meclizine is combined with Phensuximide.Approved
PhenterminePhentermine may decrease the sedative and stimulatory activities of Meclizine.Approved, Illicit
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Meclizine.Approved, Vet Approved
PiclozotanThe risk or severity of adverse effects can be increased when Meclizine is combined with Piclozotan.Investigational
PimavanserinThe risk or severity of adverse effects can be increased when Meclizine is combined with Pimavanserin.Approved, Investigational
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Meclizine.Approved
PinazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Pinazepam.Experimental
PindololThe risk or severity of adverse effects can be increased when Meclizine is combined with Pindolol.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Pipamperone.Approved, Investigational
PipecuroniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Pipecuronium.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Pipotiazine.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Meclizine is combined with Piritramide.Approved, Investigational
PirlimycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Pirlimycin.Vet Approved
PirlindoleThe risk or severity of adverse effects can be increased when Meclizine is combined with Pirlindole.Approved
PitolisantThe therapeutic efficacy of Pitolisant can be decreased when used in combination with Meclizine.Approved, Investigational
PivagabineThe risk or severity of adverse effects can be increased when Meclizine is combined with Pivagabine.Investigational
PivhydrazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Pivhydrazine.Withdrawn
PizotifenThe risk or severity of adverse effects can be increased when Meclizine is combined with Pizotifen.Approved
PlazomicinThe risk or severity of adverse effects can be increased when Meclizine is combined with Plazomicin.Approved, Investigational
Polymyxin B SulfateThe risk or severity of adverse effects can be increased when Meclizine is combined with Polymyxin B Sulfate.Approved, Vet Approved
PomalidomideThe risk or severity of adverse effects can be increased when Meclizine is combined with Pomalidomide.Approved
PramipexoleMeclizine may increase the sedative activities of Pramipexole.Approved, Investigational
PrazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Prazepam.Approved, Illicit
PregabalinThe therapeutic efficacy of Meclizine can be increased when used in combination with Pregabalin.Approved, Illicit, Investigational
PridinolThe risk or severity of adverse effects can be increased when Meclizine is combined with Pridinol.Experimental
PrimidoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Primidone.Approved, Vet Approved
ProcainamideThe risk or severity of adverse effects can be increased when Meclizine is combined with Procainamide.Approved
ProcaineThe risk or severity of adverse effects can be increased when Meclizine is combined with Procaine.Approved, Investigational, Vet Approved
ProcarbazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Procarbazine.Approved, Investigational
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Meclizine.Approved, Vet Approved
ProgabideThe risk or severity of adverse effects can be increased when Meclizine is combined with Progabide.Approved, Investigational
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Meclizine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Promethazine.Approved, Investigational
PropanididThe risk or severity of adverse effects can be increased when Meclizine is combined with Propanidid.Experimental
PropericiazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Propericiazine.Approved, Investigational
PropiomazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Propiomazine.Approved
PropiopromazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Propiopromazine.Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Meclizine.Approved, Investigational, Vet Approved
ProthipendylThe risk or severity of adverse effects can be increased when Meclizine is combined with Prothipendyl.Investigational
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Meclizine.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Meclizine is combined with Proxibarbal.Experimental
PRX-08066The risk or severity of adverse effects can be increased when Meclizine is combined with PRX-08066.Investigational
PseudoephedrinePseudoephedrine may decrease the sedative and stimulatory activities of Meclizine.Approved
PsilocybineThe risk or severity of adverse effects can be increased when Meclizine is combined with Psilocybine.Investigational
PuromycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Puromycin.Experimental
PyrantelThe risk or severity of adverse effects can be increased when Meclizine is combined with Pyrantel.Approved, Vet Approved
PyrithyldioneThe risk or severity of adverse effects can be increased when Meclizine is combined with Pyrithyldione.Experimental
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Meclizine.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Meclizine.Approved
QuinidineThe risk or severity of adverse effects can be increased when Meclizine is combined with Quinidine.Approved, Investigational
QuinineThe risk or severity of adverse effects can be increased when Meclizine is combined with Quinine.Approved
QuinupramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Quinupramine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Meclizine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Meclizine is combined with Ramelteon.Approved, Investigational
RamosetronThe risk or severity of adverse effects can be increased when Meclizine is combined with Ramosetron.Approved, Investigational
RapacuroniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Rapacuronium.Withdrawn
RasagilineThe risk or severity of adverse effects can be increased when Meclizine is combined with Rasagiline.Approved
ReboxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Reboxetine.Approved, Investigational
RemacemideThe risk or severity of adverse effects can be increased when Meclizine is combined with Remacemide.Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Meclizine.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Meclizine is combined with Remoxipride.Approved, Withdrawn
RenzaprideThe risk or severity of adverse effects can be increased when Meclizine is combined with Renzapride.Investigational
RepinotanThe risk or severity of adverse effects can be increased when Meclizine is combined with Repinotan.Investigational
ReposalThe risk or severity of adverse effects can be increased when Meclizine is combined with Reposal.Approved
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Meclizine.Approved, Investigational
RibostamycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Ribostamycin.Approved, Investigational
RiluzoleThe risk or severity of adverse effects can be increased when Meclizine is combined with Riluzole.Approved, Investigational
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Meclizine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Meclizine is combined with Ritanserin.Investigational
RitobegronRitobegron may decrease the sedative and stimulatory activities of Meclizine.Investigational
RizatriptanThe risk or severity of adverse effects can be increased when Meclizine is combined with Rizatriptan.Approved
RocuroniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Rocuronium.Approved
RolipramThe risk or severity of adverse effects can be increased when Meclizine is combined with Rolipram.Investigational
RolitetracyclineThe risk or severity of adverse effects can be increased when Meclizine is combined with Rolitetracycline.Approved
RomifidineThe risk or severity of adverse effects can be increased when Meclizine is combined with Romifidine.Vet Approved
RopiniroleMeclizine may increase the sedative activities of Ropinirole.Approved, Investigational
RotigotineMeclizine may increase the sedative activities of Rotigotine.Approved
RP-5063The risk or severity of adverse effects can be increased when Meclizine is combined with RP-5063.Investigational
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Meclizine.Approved
SafinamideThe risk or severity of adverse effects can be increased when Meclizine is combined with Safinamide.Approved, Investigational
SafrazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Safrazine.Withdrawn
SaredutantThe risk or severity of adverse effects can be increased when Meclizine is combined with Saredutant.Investigational
SarpogrelateThe risk or severity of adverse effects can be increased when Meclizine is combined with Sarpogrelate.Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Scopolamine.Approved, Investigational
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Meclizine.Approved, Vet Approved
SelegilineThe risk or severity of adverse effects can be increased when Meclizine is combined with Selegiline.Approved, Investigational, Vet Approved
SerotoninThe risk or severity of adverse effects can be increased when Meclizine is combined with Serotonin.Investigational, Nutraceutical
SertindoleThe risk or severity of adverse effects can be increased when Meclizine is combined with Sertindole.Approved, Investigational, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Meclizine is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Meclizine.Approved, Vet Approved
SibutramineThe risk or severity of adverse effects can be increased when Meclizine is combined with Sibutramine.Approved, Illicit, Investigational, Withdrawn
SisomicinThe risk or severity of adverse effects can be increased when Meclizine is combined with Sisomicin.Investigational
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved
St. John's WortThe risk or severity of adverse effects can be increased when Meclizine is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StiripentolThe risk or severity of adverse effects can be increased when Meclizine is combined with Stiripentol.Approved
StreptomycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Streptomycin.Approved, Vet Approved
StyramateThe risk or severity of adverse effects can be increased when Meclizine is combined with Styramate.Experimental
SuccinylcholineThe risk or severity of adverse effects can be increased when Meclizine is combined with Succinylcholine.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Meclizine.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Meclizine is combined with Sulpiride.Approved, Investigational
SulthiameThe risk or severity of adverse effects can be increased when Meclizine is combined with Sulthiame.Experimental
SultoprideThe risk or severity of adverse effects can be increased when Meclizine is combined with Sultopride.Experimental
SumatriptanThe risk or severity of adverse effects can be increased when Meclizine is combined with Sumatriptan.Approved, Investigational
SuvorexantMeclizine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved, Investigational
TalbutalThe risk or severity of adverse effects can be increased when Meclizine is combined with Talbutal.Approved, Illicit
TalopramThe risk or severity of adverse effects can be increased when Meclizine is combined with Talopram.Experimental
TandospironeThe risk or severity of adverse effects can be increased when Meclizine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Meclizine is combined with Tasimelteon.Approved, Investigational
TD-8954The risk or severity of adverse effects can be increased when Meclizine is combined with TD-8954.Investigational
Tedizolid phosphateThe risk or severity of adverse effects can be increased when Meclizine is combined with Tedizolid phosphate.Approved
TegaserodThe risk or severity of adverse effects can be increased when Meclizine is combined with Tegaserod.Approved, Investigational, Withdrawn
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Meclizine.Approved, Investigational
TetracyclineThe risk or severity of adverse effects can be increased when Meclizine is combined with Tetracycline.Approved, Vet Approved
TetrahydrocannabivarinThe risk or severity of adverse effects can be increased when Meclizine is combined with Tetrahydrocannabivarin.Investigational
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Meclizine is combined with Tetrahydropalmatine.Investigational
TetrazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Tetrazepam.Experimental
TetrodotoxinThe risk or severity of adverse effects can be increased when Meclizine is combined with Tetrodotoxin.Investigational
ThalidomideMeclizine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Meclizine is combined with Thiamylal.Approved, Vet Approved
ThiazinamThe risk or severity of adverse effects can be increased when Meclizine is combined with Thiazinam.Experimental
ThiethylperazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Thiethylperazine.Withdrawn
ThiocolchicosideThe risk or severity of adverse effects can be increased when Meclizine is combined with Thiocolchicoside.Approved, Investigational
ThiopentalThe risk or severity of adverse effects can be increased when Meclizine is combined with Thiopental.Approved, Vet Approved
ThiopropazateThe risk or severity of adverse effects can be increased when Meclizine is combined with Thiopropazate.Experimental
ThioproperazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Thioproperazine.Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Meclizine.Approved, Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Meclizine.Approved
TiagabineThe risk or severity of adverse effects can be increased when Meclizine is combined with Tiagabine.Approved, Investigational
TianeptineThe risk or severity of adverse effects can be increased when Meclizine is combined with Tianeptine.Approved, Investigational
TiaprideThe risk or severity of adverse effects can be increased when Meclizine is combined with Tiapride.Approved, Investigational
TigecyclineThe risk or severity of adverse effects can be increased when Meclizine is combined with Tigecycline.Approved
TiletamineThe risk or severity of adverse effects can be increased when Meclizine is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Meclizine is combined with Tilidine.Experimental
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Meclizine.Approved, Investigational
TobramycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Tobramycin.Approved, Investigational
TofisopamThe risk or severity of adverse effects can be increased when Meclizine is combined with Tofisopam.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Meclizine.Approved, Withdrawn
ToloxatoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Toloxatone.Approved
TolperisoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Tolperisone.Approved, Investigational
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Meclizine.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Meclizine.Approved, Investigational
TramiprosateThe risk or severity of adverse effects can be increased when Meclizine is combined with Tramiprosate.Investigational
TranylcypromineThe risk or severity of adverse effects can be increased when Meclizine is combined with Tranylcypromine.Approved, Investigational
TrazodoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Trazodone.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Meclizine.Approved, Investigational
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Meclizine is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Meclizine is combined with Trichloroethylene.Approved
TriclofosThe risk or severity of adverse effects can be increased when Meclizine is combined with Triclofos.Withdrawn
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Meclizine.Approved, Investigational
TrifluperidolThe risk or severity of adverse effects can be increased when Meclizine is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe risk or severity of adverse effects can be increased when Meclizine is combined with Trimethadione.Approved
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Meclizine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Meclizine.Approved
TropisetronThe risk or severity of adverse effects can be increased when Meclizine is combined with Tropisetron.Approved, Investigational
TubocurarineThe risk or severity of adverse effects can be increased when Meclizine is combined with Tubocurarine.Approved
UrapidilThe risk or severity of adverse effects can be increased when Meclizine is combined with Urapidil.Investigational
VabicaserinThe risk or severity of adverse effects can be increased when Meclizine is combined with Vabicaserin.Investigational
ValerianThe risk or severity of adverse effects can be increased when Meclizine is combined with Valerian.Approved, Experimental, Investigational
ValnoctamideThe risk or severity of adverse effects can be increased when Meclizine is combined with Valnoctamide.Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Meclizine is combined with Valproic Acid.Approved, Investigational
ValpromideThe risk or severity of adverse effects can be increased when Meclizine is combined with Valpromide.Experimental
VancomycinThe risk or severity of adverse effects can be increased when Meclizine is combined with Vancomycin.Approved
VecuroniumThe risk or severity of adverse effects can be increased when Meclizine is combined with Vecuronium.Approved
VenlafaxineThe risk or severity of adverse effects can be increased when Meclizine is combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Meclizine is combined with Veralipride.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Meclizine is combined with Vigabatrin.Approved
VilazodoneThe risk or severity of adverse effects can be increased when Meclizine is combined with Vilazodone.Approved
ViloxazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Viloxazine.Approved, Investigational, Withdrawn
VinbarbitalThe risk or severity of adverse effects can be increased when Meclizine is combined with Vinbarbital.Experimental
VinpocetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Vinpocetine.Investigational
Vinyl etherThe risk or severity of adverse effects can be increased when Meclizine is combined with Vinyl ether.Experimental
VinylbitalThe risk or severity of adverse effects can be increased when Meclizine is combined with Vinylbital.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Meclizine is combined with Vortioxetine.Approved, Investigational
WortmanninThe risk or severity of adverse effects can be increased when Meclizine is combined with Wortmannin.Experimental
XP19986The risk or severity of adverse effects can be increased when Meclizine is combined with XP19986.Investigational
XylazineThe risk or severity of adverse effects can be increased when Meclizine is combined with Xylazine.Vet Approved
YKP-1358The risk or severity of adverse effects can be increased when Meclizine is combined with YKP-1358.Investigational
YohimbineThe risk or severity of adverse effects can be increased when Meclizine is combined with Yohimbine.Approved, Investigational, Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Meclizine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Meclizine is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Meclizine is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Meclizine.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Meclizine is combined with Zolazepam.Vet Approved
ZolmitriptanThe risk or severity of adverse effects can be increased when Meclizine is combined with Zolmitriptan.Approved, Investigational
ZolpidemMeclizine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Meclizine is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Meclizine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Meclizine is combined with Zotepine.Approved, Investigational, Withdrawn
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Meclizine.Approved, Investigational
Food Interactions
  • Take with food to reduce irritation. Avoid alcohol.

References

Synthesis Reference

U.S. Patent 2,709,169.

General References
Not Available
External Links
Human Metabolome Database
HMDB0014875
KEGG Compound
C07116
PubChem Compound
4034
PubChem Substance
46507782
ChemSpider
3894
BindingDB
81467
ChEBI
6709
ChEMBL
CHEMBL1623
Therapeutic Targets Database
DAP000795
PharmGKB
PA450338
IUPHAR
2757
Guide to Pharmacology
GtP Drug Page
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Meclizine
ATC Codes
R06AE55 — Meclozine, combinationsR06AE05 — Meclozine
AHFS Codes
  • 56:22.08 — Antihistamines

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentHealthy Volunteers1
1RecruitingTreatmentHepatocellular,Carcinoma1
2CompletedTreatmentCessation, Smoking1
3RecruitingTreatmentVertigo, Peripheral1
4RecruitingOtherDrug Reaction1
Not AvailableCompletedPreventionProphylaxis against postoperative nausea and vomiting1
Not AvailableCompletedTreatmentBenign Paroxysmal Positional Vertigo (BPPV)1

Pharmacoeconomics

Manufacturers
  • Pfizer inc
Packagers
  • Advanced Pharmaceutical Services Inc.
  • Aidarex Pharmacuticals LLC
  • AJ Bart
  • Apotheca Inc.
  • A-S Medication Solutions LLC
  • Blenheim Pharmacal
  • Bryant Ranch Prepack
  • Cadista Pharmaceuticals Inc.
  • Cardinal Health
  • Dept Health Central Pharmacy
  • Direct Dispensing Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • Group Health Cooperative
  • H and H Laboratories
  • H.J. Harkins Co. Inc.
  • Heartland Repack Services LLC
  • Innoviant Pharmacy Inc.
  • Kaiser Foundation Hospital
  • Kraft Pharmaceutical Co. Inc.
  • Lake Erie Medical and Surgical Supply
  • Liberty Pharmaceuticals
  • Major Pharmaceuticals
  • Mckesson Corp.
  • Med Tek Pharmaceuticals Inc.
  • Medique Products
  • Medisca Inc.
  • Murfreesboro Pharmaceutical Nursing Supply
  • Nexgen Pharma Inc.
  • Nucare Pharmaceuticals Inc.
  • Palmetto Pharmaceuticals Inc.
  • Par Pharmaceuticals
  • Patheon Inc.
  • Patient First Corp.
  • PCA LLC
  • PD-Rx Pharmaceuticals Inc.
  • Pfizer Inc.
  • Pharmaceutical Utilization Management Program VA Inc.
  • Pharmacia Inc.
  • Pharmedix
  • Pharmpak Inc.
  • Physicians Total Care Inc.
  • Preferred Pharmaceuticals Inc.
  • Prepackage Specialists
  • Prepak Systems Inc.
  • Prescript Pharmaceuticals
  • Qualitest
  • Rebel Distributors Corp.
  • Redpharm Drug
  • Remedy Repack
  • Sandoz
  • Stat Rx Usa
  • Stat Scripts LLC
  • Sunmark
  • Tya Pharmaceuticals
  • UDL Laboratories
  • United Research Laboratories Inc.
  • Vangard Labs Inc.
  • Veratex Corp.
  • Watson Pharmaceuticals
Dosage forms
FormRouteStrength
TabletOral
Tablet, multilayer, extended releaseOral25 mg
Tablet, chewableOral25 mg
Tablet, orally disintegratingOral25 mg/1
TabletOral25 mg/1
TabletOral12.5 mg/1
TabletOral50 mg/1
Tablet, film coatedOral25 mg/1
Tablet, chewableOral25 mg/251
Tablet, film coatedOral12.5 mg/1
Tablet, chewableOral25 mg/1
Film, solubleOral25 mg/1
Prices
Unit descriptionCostUnit
Meclizine HCl 100 25 mg tablet Box89.97USD box
Antivert 50 mg tablet2.12USD tablet
Antivert 25 mg tablet1.23USD tablet
Meclizine hcl powder1.04USD g
Vertin-32 tablet0.9USD tablet
Antivert 12.5 mg tablet0.82USD tablet
Meclizine HCl 25 mg tablet0.67USD tablet
Meclizine 12.5 mg tablet0.62USD tablet
Sm motion sicknes 25 mg tablet0.5USD tablet
Meclizine HCl 12.5 mg tablet0.43USD tablet
Dramamine less drowsy tablet0.42USD tablet
Bonamine 25 mg Chewable Tablet0.33USD tablet
Dramamine 50 mg tablet0.28USD tablet
Meclizine 25 mg tablet0.07USD tablet
Medi-meclizine 25 mg tablet0.06USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)217-224U.S. Patent 2,709,169.
water solubility0.1gm/100mlNot Available
logP5.8Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00103 mg/mLALOGPS
logP5.59ALOGPS
logP6.39ChemAxon
logS-5.6ALOGPS
pKa (Strongest Basic)8.16ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area6.48 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity119.39 m3·mol-1ChemAxon
Polarizability44.87 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9318
Blood Brain Barrier+0.9656
Caco-2 permeable+0.6369
P-glycoprotein substrateSubstrate0.7422
P-glycoprotein inhibitor IInhibitor0.8149
P-glycoprotein inhibitor IINon-inhibitor0.8042
Renal organic cation transporterInhibitor0.7859
CYP450 2C9 substrateNon-substrate0.8416
CYP450 2D6 substrateNon-substrate0.5134
CYP450 3A4 substrateNon-substrate0.6059
CYP450 1A2 substrateInhibitor0.806
CYP450 2C9 inhibitorNon-inhibitor0.9698
CYP450 2D6 inhibitorInhibitor0.9521
CYP450 2C19 inhibitorInhibitor0.5209
CYP450 3A4 inhibitorNon-inhibitor0.8896
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.7063
Ames testNon AMES toxic0.8536
CarcinogenicityNon-carcinogens0.9343
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.3803 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.6113
hERG inhibition (predictor II)Inhibitor0.8104
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-052r-1920000000-da1d25573308648315fa
Mass Spectrum (Electron Ionization)MSsplash10-0ap0-1910000000-a39cf62803f22b3df281
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0udi-0090000000-66c42b235873c2a66976
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0udi-0090000000-02a85fbc5761853f587f
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0uxr-0590000000-4633d1c1f89a98d9a694
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0gb9-0940000000-38b1d47fb87eb43db9bd
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-014i-0910000000-0787c462628db9403567
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-014i-0900000000-9b3d5063cf1e4fd0ecda
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0udi-0390000000-10b11855a2539537e5af

Taxonomy

Description
This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Diphenylmethanes
Direct Parent
Diphenylmethanes
Alternative Parents
Phenylmethylamines / Benzylamines / Toluenes / N-alkylpiperazines / Chlorobenzenes / Aralkylamines / Aryl chlorides / Trialkylamines / Azacyclic compounds / Organopnictogen compounds
show 2 more
Substituents
Diphenylmethane / Benzylamine / Phenylmethylamine / Chlorobenzene / Halobenzene / Aralkylamine / N-alkylpiperazine / Toluene / Aryl chloride / Aryl halide
show 14 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
diarylmethane (CHEBI:6709)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Histamine receptor activity
Specific Function
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamin...
Gene Name
HRH1
Uniprot ID
P35367
Uniprot Name
Histamine H1 receptor
Molecular Weight
55783.61 Da
References
  1. Oishi R, Shishido S, Yamori M, Saeki K: Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 1994 Feb;349(2):140-4. [PubMed:7513381]
  2. Martins MA, Pasquale CP, e Silva PM, Pires AL, Ruffie C, Rihoux JP, Cordeiro RS, Vargaftig BB: Interference of cetirizine with the late eosinophil accumulation induced by either PAF or compound 48/80. Br J Pharmacol. 1992 Jan;105(1):176-80. [PubMed:1350745]
  3. Pasquale CP, e Silva PM, Lima MC, Diaz BL, Rihoux JP, Vargaftig BB, Cordeiro RS, Martins MA: Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized rats. Eur J Pharmacol. 1992 Nov 13;223(1):9-14. [PubMed:1362160]
  4. Taniguchi K, Masuda Y, Takanaka K: Inhibitory effects of histamine H1 receptor blocking drugs on metabolic activations of neutrophils. J Pharmacobiodyn. 1991 Feb;14(2):87-93. [PubMed:1678430]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inverse agonist
General Function
Zinc ion binding
Specific Function
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital re...
Gene Name
NR1I3
Uniprot ID
Q14994
Uniprot Name
Nuclear receptor subfamily 1 group I member 3
Molecular Weight
39942.145 Da
References
  1. Huang W, Zhang J, Wei P, Schrader WT, Moore DD: Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol Endocrinol. 2004 Oct;18(10):2402-8. Epub 2004 Jul 22. [PubMed:15272053]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on June 13, 2005 07:24 / Updated on August 15, 2018 09:44