Vitamin B Complex

A group of water-soluble vitamins, some of which are COENZYMES.
DrugDrug NameDrug Indication
DB00115CyanocobalaminFor treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.
DB00121BiotinFor nutritional supplementation, also for treating dietary shortage or imbalance.
DB00140RiboflavinFor the treatment of ariboflavinosis (vitamin B2 deficiency).
DB00152ThiamineFor the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.
DB00158Folic AcidFor treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood.
DB00165PyridoxineFor the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
DB00200HydroxocobalaminFor treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets or other restrictive diets. Also for the treatment of known or suspected cyanide poisoning.
DB00627NiacinFor the treatment of type IV and V hyperlipidemia. It is indicated as ajunctive therapy.
DB01783Pantothenic acidStudied for the treatment of many uses such as treatment of testicular torsion, diabetic ulceration, wound healing, acne, obesity, diabetic peripheral polyneuropathy. It has also been investigated for its hypolipidemic effects and as cholesterol lowering agent.
DB02701NicotinamideNot Available
DB00114Pyridoxal PhosphateFor nutritional supplementation and for treating dietary shortage or imbalance.
DB00147PyridoxalPyridoxal is one of the natural forms available of vitamin B6, therefore, it is used for nutritional supplementation and for treating dietary shortage or imbalances.
DB00166Lipoic AcidFor nutritional supplementation, also for treating dietary shortage or imbalance.
DB00650LeucovorinFor the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.
DB08842AcetylcarnitineAcetylcarnitine is not approved for any indication in the United states and Canada, but it is approved and indicated in Italy for cerebrovascular disorders, mental function disorders, peripheral nerve disorders, diabetic neuropathy, and nutritional supplementation; Portugal for mental function disorders; Argentina for cerebral vasculopathy, nutritional supplementation, and peripheral neuropathy; Chile for dementia; Philippines for cerebrovascular disorders and mental function disorders; Australia for nutritional supplementation; and India for nutritional supplementation to increase sperm count. Acetylcarnitine also has several potential therapeutic indications for which it is still being investigated: in Norway, acetylcarnitine is in a phase IV trial for prophylactic treatment of migraines; in Italy acetylcarnitine is in a phase II trial for use in patients with type 2 Diabetes Mellitus, a phase III trial for alleviating fatigue in patients with chronic hepatitis C, and for use in patients with Minimal Hepatic Encephalopathy; in the United States acetylcarnitine is in a phase II trial for the neurodegenerative disorder Progressive Supranuclear Palsy, a phase II and III trial for reducing peripheral neuropathy in cancer patients as an adjunct to chemotherapy, a phase I and II trial for treating patients in septic shock, a phase II trial for bipolar depression, a phase II trial to reduce oxidative stress in patients with Sickle Cell disease, a phase I and II trial for chronic fatigue syndrome, and a study for preventing nerve damage in HIV patients; in China acetylcarnitine is in a phase III trial for reducing peripheral neuropathy in cancer patients as an adjunct to chemotherapy; in the United Kingdom acetylcarnitine is being investigated for preventing nerve damage in HIV patients; and in Israel acetylcarnitine is being studied for the treatment of male infertility.
DB08966FursultiamineNot Available
DB09220NicorandilIndicated for the prevention and treatment of chronic stable angina pectoris and reduction in the risk of acute coronary syndromes.
DB09357DexpanthenolInjection: Prophylactic use immediately after major abdominal surgery to minimize the possibility of paralytic ileus. Intestinal atony causing abdominal distention; postoperative or postpartum retention of flatus, or postoperative delay in resumption of intestinal motility; paralytic ileus. Topical: This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy).
DB11596LevoleucovorinLevoleucovorin is indicated for use as rescue therapy following high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid antagonists. Levoleucovorin, as the product Fusilev (FDA, dosed at one-half the usual dose of racemic d,l-leucovorin), has an additional indication for use in combination chemotherapy with 5-fluorouracil in the palliative treatment of patients with advanced metastatic colorectal cancer (although they should not be mixed in the same infusion as a precipitate may form).
DB11673PyridoxamineNot Available
DB13178myo-inositolNot Available
DB00122CholineFor nutritional supplementation, also for treating dietary shortage or imbalance
DB08949Inositol nicotinateIndicated as a dietary supplement for the source of niacin. Has been investigated for potential beneficial effects on serum lipids. In Europe, inositol hexanicotinate is indicated as a patented drug known as Hexopal, which is therapeutically indicated for the symptomatic relief of severe intermittent claudication and Raynaud’s phenomenon.
DrugDrug NameTargetType
DB00115CyanocobalaminMethionine synthase reductasetarget
DB00115CyanocobalaminMethylmalonic aciduria type A protein, mitochondrialtarget
DB00115CyanocobalaminMethylmalonyl-CoA mutase, mitochondrialtarget
DB00115CyanocobalaminMethylmalonic aciduria and homocystinuria type C proteintarget
DB00115CyanocobalaminMethionine synthasetarget
DB00115CyanocobalaminMethylenetetrahydrofolate reductasetarget
DB00115CyanocobalaminProtein amnionlesstransporter
DB00115CyanocobalaminTranscobalamin-1transporter
DB00115CyanocobalaminTranscobalamin-2transporter
DB00115CyanocobalaminCob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialenzyme
DB00115CyanocobalaminGastric intrinsic factortransporter
DB00115CyanocobalaminCubilintransporter
DB00121BiotinPropionyl-CoA carboxylase beta chain, mitochondrialtarget
DB00121BiotinBiotin--protein ligasetarget
DB00121BiotinSodium-dependent multivitamin transportertarget
DB00121BiotinMethylcrotonoyl-CoA carboxylase beta chain, mitochondrialtarget
DB00121BiotinAcetyl-CoA carboxylase 2target
DB00121BiotinMethylcrotonoyl-CoA carboxylase subunit alpha, mitochondrialtarget
DB00121BiotinPyruvate carboxylase, mitochondrialtarget
DB00121BiotinPropionyl-CoA carboxylase alpha chain, mitochondrialtarget
DB00121BiotinAcetyl-CoA carboxylase 1target
DB00121BiotinCytochrome P450 1B1enzyme
DB00140RiboflavinFlavin reductase (NADPH)target
DB00140RiboflavinRiboflavin kinasetarget
DB00140RiboflavinRiboflavin synthasetarget
DB00140RiboflavinAmine oxidase [flavin-containing] Aenzyme
DB00140RiboflavinMethylenetetrahydrofolate reductaseenzyme
DB00140RiboflavinSolute carrier family 22 member 6transporter
DB00152ThiamineThiamin pyrophosphokinase 1target
DB00152ThiamineSolute carrier family 22 member 2transporter
DB00152ThiamineSolute carrier family 22 member 1transporter
DB00152ThiamineSolute carrier family 22 member 5transporter
DB00152ThiamineThiamine transporter 1target
DB00152ThiamineCytochrome P450 4B1enzyme
DB00158Folic AcidFolate receptor gammatarget
DB00158Folic AcidFolate receptor betatarget
DB00158Folic AcidMethylenetetrahydrofolate reductaseenzyme
DB00158Folic AcidMultidrug resistance-associated protein 4transporter
DB00158Folic AcidSolute carrier family 22 member 6transporter
DB00158Folic AcidCanalicular multispecific organic anion transporter 2transporter
DB00158Folic AcidATP-binding cassette sub-family C member 11transporter
DB00158Folic AcidATP-binding cassette sub-family G member 2transporter
DB00158Folic AcidCytochrome P450 2E1enzyme
DB00158Folic AcidProton-coupled folate transportertransporter
DB00158Folic AcidMitochondrial folate transporter/carriertransporter
DB00158Folic AcidGamma-glutamyl hydrolaseenzyme
DB00158Folic AcidSerum albumincarrier
DB00158Folic AcidFolate receptor alphatarget
DB00165PyridoxinePyridoxal kinasetarget
DB00165PyridoxineCytochrome P450 1A1enzyme
DB00200HydroxocobalaminMethylmalonic aciduria type A protein, mitochondrialtarget
DB00200HydroxocobalaminProtein amnionlesstarget
DB00200HydroxocobalaminTranscobalamin-1target
DB00200HydroxocobalaminMethylmalonyl-CoA mutase, mitochondrialtarget
DB00200HydroxocobalaminMethionine synthase reductasetarget
DB00200HydroxocobalaminCob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialtarget
DB00200HydroxocobalaminMethionine synthasetarget
DB00200HydroxocobalaminCubilintarget
DB00200HydroxocobalaminMethylmalonic aciduria and homocystinuria type C proteintarget
DB00200HydroxocobalaminTranscobalamin-2carrier
DB00627NiacinHydroxycarboxylic acid receptor 2target
DB00627NiacinNicotinamide N-methyltransferasetarget
DB00627NiacinNicotinate-nucleotide pyrophosphorylase [carboxylating]target
DB00627NiacinHydroxycarboxylic acid receptor 3target
DB00627NiacinSolute carrier family 22 member 5transporter
DB00627NiacinSolute carrier organic anion transporter family member 2B1transporter
DB00627NiacinMonocarboxylate transporter 1transporter
DB00627NiacinCytochrome P450 2D6enzyme
DB00627NiacinSodium-coupled monocarboxylate transporter 1transporter
DB00627NiacinMonocarboxylate transporter 4transporter
DB01783Pantothenic acidPantothenate kinasetarget
DB02701NicotinamideNAD-dependent protein deacylase sirtuin-5, mitochondrialtarget
DB02701NicotinamideADP-ribosyl cyclase 2target
DB02701NicotinamideExotoxin Atarget
DB02701NicotinamideL-lactate dehydrogenase A chaintarget
DB02701NicotinamidePoly [ADP-ribose] polymerase 1target
DB02701NicotinamideCytochrome P450 2D6enzyme
DB02701NicotinamideCytochrome P450 2E1enzyme
DB02701NicotinamideCytochrome P450 3A4enzyme
DB00114Pyridoxal PhosphateCystathionine beta-synthasetarget
DB00114Pyridoxal PhosphateAlanine--glyoxylate aminotransferase 2, mitochondrialtarget
DB00114Pyridoxal PhosphateGlutamate decarboxylase 1target
DB00114Pyridoxal PhosphateKynureninasetarget
DB00114Pyridoxal PhosphateSerine hydroxymethyltransferase, cytosolictarget
DB00114Pyridoxal PhosphateCysteine desulfurase, mitochondrialtarget
DB00114Pyridoxal PhosphateAspartate aminotransferase, cytoplasmictarget
DB00114Pyridoxal PhosphateOrnithine aminotransferase, mitochondrialtarget
DB00114Pyridoxal PhosphateOrnithine decarboxylasetarget
DB00114Pyridoxal PhosphateKynurenine/alpha-aminoadipate aminotransferase, mitochondrialtarget
DB00114Pyridoxal Phosphate4-aminobutyrate aminotransferase, mitochondrialtarget
DB00114Pyridoxal PhosphatePyridoxine-5'-phosphate oxidasetarget
DB00114Pyridoxal PhosphateSphingosine-1-phosphate lyase 1target
DB00114Pyridoxal PhosphateTyrosine aminotransferasetarget
DB00114Pyridoxal PhosphateKynurenine--oxoglutarate transaminase 1target
DB00114Pyridoxal PhosphateThreonine synthase-like 1target
DB00114Pyridoxal PhosphateGlycogen phosphorylase, liver formtarget
DB00114Pyridoxal PhosphateSerine palmitoyltransferase 2target
DB00114Pyridoxal PhosphateCysteine sulfinic acid decarboxylasetarget
DB00114Pyridoxal PhosphateHistidine decarboxylasetarget
DB00114Pyridoxal PhosphateArginine decarboxylasetarget
DB00114Pyridoxal PhosphateL-serine dehydratase/L-threonine deaminasetarget
DB00114Pyridoxal Phosphate2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialtarget
DB00114Pyridoxal PhosphateGlycine dehydrogenase [decarboxylating], mitochondrialtarget
DB00114Pyridoxal PhosphateAlanine aminotransferase 1target
DB00114Pyridoxal PhosphatePhosphoserine aminotransferasetarget
DB00114Pyridoxal Phosphate5-aminolevulinate synthase, nonspecific, mitochondrialtarget
DB00114Pyridoxal PhosphateSerine--pyruvate aminotransferasetarget
DB00114Pyridoxal PhosphatePyridoxal phosphate phosphatasetarget
DB00114Pyridoxal PhosphateSerine palmitoyltransferase 1target
DB00114Pyridoxal PhosphateCystathionine gamma-lyasetarget
DB00114Pyridoxal PhosphateBranched-chain-amino-acid aminotransferase, cytosolictarget
DB00114Pyridoxal PhosphateBranched-chain-amino-acid aminotransferase, mitochondrialtarget
DB00114Pyridoxal PhosphateProline synthase co-transcribed bacterial homolog proteintarget
DB00114Pyridoxal PhosphateFormimidoyltransferase-cyclodeaminasetarget
DB00114Pyridoxal PhosphateAspartate aminotransferase, mitochondrialtarget
DB00114Pyridoxal PhosphateGlycogen phosphorylase, brain formtarget
DB00114Pyridoxal PhosphateGlycogen phosphorylase, muscle formtarget
DB00114Pyridoxal PhosphateAromatic-L-amino-acid decarboxylasetarget
DB00114Pyridoxal PhosphateAspartate aminotransferasetarget
DB00114Pyridoxal PhosphateGAD1 proteintarget
DB00114Pyridoxal PhosphateSerine hydroxymethyltransferasetarget
DB00114Pyridoxal PhosphateSelenocysteine lyase varianttarget
DB00114Pyridoxal PhosphatePhosphorylasetarget
DB00114Pyridoxal PhosphateOrnithine aminotransferase varianttarget
DB00114Pyridoxal Phosphate5-aminolevulinate synthasetarget
DB00114Pyridoxal PhosphateGlutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)target
DB00114Pyridoxal PhosphateDDC proteintarget
DB00114Pyridoxal PhosphatePyridoxal-dependent decarboxylase domain-containing protein 1target
DB00114Pyridoxal PhosphateKynurenine--oxoglutarate transaminase 3target
DB00114Pyridoxal PhosphateGlutamate decarboxylase-like protein 1target
DB00114Pyridoxal PhosphateSelenocysteine lyasetarget
DB00114Pyridoxal PhosphateImmunoglobulin superfamily member 10target
DB00114Pyridoxal Phosphate5-phosphohydroxy-L-lysine phospho-lyasetarget
DB00114Pyridoxal PhosphateGlutamate decarboxylase 1 (Brain, 67kDa)target
DB00114Pyridoxal PhosphateSerine hydroxymethyltransferase, mitochondrialtarget
DB00114Pyridoxal Phosphate5-aminolevulinate synthase, erythroid-specific, mitochondrialtarget
DB00114Pyridoxal PhosphateAlanine aminotransferase 2target
DB00114Pyridoxal PhosphateMolybdenum cofactor sulfurasetarget
DB00114Pyridoxal PhosphateSerine dehydratase-liketarget
DB00114Pyridoxal PhosphateP-selectin cytoplasmic tail-associated protein (PCAP)target
DB00114Pyridoxal PhosphateHepatic peroxysomal alanine:glyoxylate aminotransferasetarget
DB00114Pyridoxal PhosphateSerine racemasetarget
DB00114Pyridoxal PhosphateO-phosphoseryl-tRNA(Sec) selenium transferasetarget
DB00114Pyridoxal PhosphateSerine palmitoyltransferase 3target
DB00114Pyridoxal PhosphateGlutamic acid decarboxylasetarget
DB00114Pyridoxal PhosphateAlanine-glyoxylate aminotransferase homologtarget
DB00147PyridoxalPyridoxal kinasetarget
DB00166Lipoic AcidLipoyltransferase 1, mitochondrialtarget
DB00166Lipoic AcidSodium-dependent multivitamin transportertarget
DB00166Lipoic AcidLipoyl synthase, mitochondrialtarget
DB00166Lipoic AcidNADPH--cytochrome P450 reductaseenzyme
DB08842AcetylcarnitineSolute carrier family 22 member 5transporter
DB08842AcetylcarnitineSolute carrier family 22 member 21transporter
DB09220NicorandilATP-binding cassette sub-family C member 9target
DB09357DexpanthenolMuscarinic acetylcholine receptor M3target
DB11596LevoleucovorinSerine hydroxymethyltransferasetarget
DB11596LevoleucovorinDihydrofolate reductasetarget
DB00122CholineCholine-phosphate cytidylyltransferase Btarget
DB00122CholineAcetylcholinesterasetarget
DB00122CholineCholine-phosphate cytidylyltransferase Atarget
DB00122CholinePhospholipase D2target
DB00122CholineCholinesterasetarget
DB00122CholinePhospholipase D1target
DB00122CholinePhosphoethanolamine/phosphocholine phosphatasetarget
DB00122CholineSolute carrier family 22 member 2transporter
DB00122CholineSolute carrier family 22 member 1transporter
DB00122CholineSolute carrier family 22 member 3transporter
DB00122CholineSolute carrier family 22 member 5transporter
DB00122CholineSolute carrier family 22 member 4transporter
DB00122CholineCholine/ethanolaminephosphotransferase 1enzyme
DB00122CholineCholine transporter-like protein 1transporter
DB00122CholineCholine transporter-like protein 4transporter
DB00122CholineCholine transporter-like protein 2transporter
DB00122CholineCholine transporter-like protein 3transporter
DB00122CholineCholine/ethanolamine kinaseenzyme
DB00122CholineCholine O-acetyltransferaseenzyme
DB00122CholineCholine kinase alphaenzyme
DB00122CholineCholine dehydrogenase, mitochondrialenzyme
DB00122CholineHigh affinity choline transporter 1transporter
DB00122CholineNeuronal acetylcholine receptor subunit alpha-7target
DB08949Inositol nicotinateSodium-coupled monocarboxylate transporter 1transporter
DB08949Inositol nicotinateATP synthase subunit beta, mitochondrialenzyme
DB08949Inositol nicotinateHydroxycarboxylic acid receptor 3target
DB08949Inositol nicotinateHydroxycarboxylic acid receptor 2target
DB08949Inositol nicotinateDiacylglycerol O-acyltransferase 2enzyme