Cardiac Therapy

Name
Cardiac Therapy
Accession Number
DBCAT002210  (DBCAT003655)
Description
Not Available
ATC Classification
Drugs
DrugDrug Description
DofetilideA class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter.
MidodrineAn alpha-adrenergic antagonist used to treat orthostatic hypotension.
MilrinoneAn inotropic vasodilator agent used to treat acute, decompensated heart failure.
RanolazineAn anti-anginal drug used for the treatment of chronic angina.
DisopyramideA class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias.
IbutilideA class III antiarrhythmic agent used to correct atrial fibrillation and atrial flutter, which can be considered as an alternative to cardioversion.
IndomethacinA nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants.
NorepinephrineA sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest.
MexiletineA class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment.
DigoxinA cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation.
AcetyldigitoxinUsed for fast digitalization in congestive heart failure.
MetaraminolFor the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage
AdenosineA medication used in myocardial perfusion scintigraphy.
MoricizineAn antiarrhythmic used to treat arrhythmias.
MethoxamineAn alpha adrenergic agonist used to treat hypotension.
NitroglycerinA nitrate vasodilator used to treat or prevent angina, treat hypertension, control heart failure in myocardial infarction, and to induce hypotension intraoperatively.
FenoldopamA dopamine D1 receptor agonist used for the short term management of hypertension.
DobutamineA beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery.
Isosorbide dinitrateA vasodilator used to treat angina in coronary artery disease.
QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
LevosimendanFor short term treatment of acutely decompensated severe chronic heart failure (CHF). Also being investigated for use/treatment in heart disease.
DopamineA catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension.
Isosorbide mononitrateA nitrate used to prevent and treat angina and to treat angina caused by coronary artery disease.
ProcainamideA medication used to treat life threatening ventricular arrhythmias.
TocainideAn orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias.
DeslanosideFor the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure.
OuabainFor the treatment of atrial fibrillation and flutter and heart failure
ArbutamineUsed to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in...
AmiodaroneA class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation.
PropafenoneA Class 1C antiarrhythmic agent used in the management of paroxysmal atrial fibrillation/flutter and ventricular arrhythmias.
FlecainideA class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT).
EncainideA voltage-gated sodium channel blocker used for management of atrial or ventricular fibrillation, atrial flutter, and ventricular tachycardia, that is no longer used due to proarrhythmic adverse effects.
MephentermineA sympathomimetic agent used in the treatment of hypotension.
DigitoxinA cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
AjmalineFor use as an antiarrhythmic agent.
AmrinoneA positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure.
AprindineAprindine is a cardiac depressant used in arrhythmias.
Erythrityl tetranitrateFor the prevention of angina.
CamphorA compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.
PrenylaminePrenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
DronedaroneAn antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation.
EnoximoneFor the treatment of congestive heart failure.
NesiritideA recombinant natriuretic peptide used for the treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity.
AcadesineInvestigated for use/treatment in cardiac reperfusion injury, cardiovascular disorders, and coronary artery disease.
SerelaxinInvestigated for use/treatment in cardiovascular disorders, congestive heart failure, infertility, peripheral vascular disease, and scleroderma.
Pentaerythritol tetranitrateUsed for the treatment of angina pectoris .
TedisamilInvestigated for use/treatment in arrhythmia, atrial fibrillation, and angina.
RegadenosonA coronary vasodilator used in radionuclide myocardial perfusion imaging (MPI).
VernakalantAn antiarrhythmic medication used to treat patients with atrial fibrillation.
DroxidopaA medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Parkinson's disease.
SparteineSparteine is a plant alkaloid derived from Cytisus scoparius and Lupinus mutabilis which may chelate calcium and magnesium. It is a sodium channel blocker so it falls under the category...
EtilefrineEtilefrine is an adrenergic agonist that appears to interact with beta-2 and some alpha adrenergic receptors. It has been used as a vasoconstrictor agent.
TrimetazidineTrimetazidine is indicated for use in angina pectoris.
IvabradineA HCN channel blocker used to reduce the risk of hospitalization for worsening heart failure in adult patients and for treatment of stable symptomatic heart failure as a result of dilated cardiomyopathy in pediatric patients.
NicorandilIndicated for the prevention and treatment of chronic stable angina pectoris and reduction in the risk of acute coronary syndromes.
UbidecarenoneA cofactor found in various dietary supplements.
MolsidomineThe indications for use of molsidomine include ischemic heart disease, angina, chronic heart failure, and pulmonary hypertension [L1370, L1371].
TrapidilUsed in the treatment of chronic stable angina .
ImolamineImolamine is indicated for the treatment of angina pectoris. The hydrochloride form is used as a local anesthetic.
DopexamineDopexamine has been used in trials studying the diagnostic and treatment of Free Flap, Oral Cancer, Hypotension, Septic Shock, and Head and Neck Cancer.
CafedrineCafedrine is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation).
TheodrenalineTheodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation).
CreatinolfosfateCOP is under investigation for the treatment of Rheumatoid Arthritis, Mature B-Cell Lymphoma, and Noninflammatory Degenerative Joint Disease. COP has been investigated for the treatment of Diabetic Retinopathy.
PhosphocreatinePhosphocreatine is a naturally occuring substance that is found predominantly in the skeletal muscles of vertebrates. Its primary utility within the body is to serve in the maintanence and recycling...
FlosequinanFlosequinan was approved in the USA and the UK for a year prior to being withdrawn from the market due to increased mortality in chronic heart failure patients, found in...
CymarinNot Annotated
BucladesineNot Annotated
OctopamineOctopamine is structurally similar to norepinephrine. It has been used as a nootropic, and therefore it and all of its enantiomer are prohibited by the World Anti-doping Agency (WADA) as...
Propatyl nitrateNot Annotated
HexobendineHexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has...
BenziodaroneBenziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout . It was withdrawn from France...
CarbocromenCarbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development .
CloridarolCloridarol is an experimental medication in the treatment of heart disease, which acts through vasodilation. It was studied for the treatment of coronary insufficiency in Italy in the 1970s .
ProscillaridinProscillaridin is a cardiac glycoside that is derived from plants of the genus Scilla and in Drimia maritima (Scilla maritima). Studies suggest the potential cytotoxic and anticancer property of proscillaridin,...
Amezinium metilsulfateNot Annotated
EfloxateNot Annotated
CinepazetNot Annotated
CibenzolineNot Annotated
NorfenefrineNot Annotated
OxyfedrineNot Annotated
LinsidomineNot Annotated
MetildigoxinNot Annotated
Methylpropylpropanediol dinitrateNot Annotated
Lanatoside CNot Annotated
DimetofrineNot Annotated
AngiotensinamideNot Annotated
GitoformateNot Annotated
PrajmalineNot Annotated
HeptaminolNot Annotated
Aminoethyl nitrateNot Annotated
TiracizineNot Annotated
TenitramineNot Annotated
EthacizineNot Annotated
LorajmineNot Annotated
BunaftineNot Annotated
LorcainideNot Annotated
AcetyldigoxinNot Annotated
GepefrineNot Annotated
DilazepNot Annotated
TrolnitrateNot Annotated
MeldoniumNot Annotated
PeruvosideNot Annotated
PrenalterolNot Annotated
XamoterolXamoterol is a β1-adrenoceptor partial agonist that has shown to improve systolic and diastolic function in studies with heart failure patients. It modulates the sympathetic control of the heart but...
EtafenoneEtafenone is a vasodilator.
FosfructoseNot Annotated
LidocaineA local anesthetic used in a wide variety of superficial and invasive procedures.
PhenylephrineAn alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
EpinephrineA hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.
AlprostadilA medication used to treat erectile dysfunction.
IsoprenalineA non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block; it is structurally related to epinephrine.
EphedrineAn alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion.
SynephrineSynephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer...
IbopamineNot Annotated
BretyliumA norepinephrine release inhibitor used for the prophylaxis and therapy of ventricular fibrillation, as well as the treatment of life-threatening ventricular arrhythmias.
Angiotensin IIA peptide hormone of the RAAS system used to raise blood pressure in septic or other forms of shock.
HydroquinidineHydroquinidine is under investigation in clinical trial NCT00927732 (Hydroquinidine Versus Placebo in Patients With Brugada Syndrome).
Drugs & Drug Targets
DrugTargetType
DofetilidePotassium channel subfamily K member 2target
DofetilidePotassium voltage-gated channel subfamily H member 2target
DofetilideATP-sensitive inward rectifier potassium channel 12target
DofetilideCytochrome P450 3A4enzyme
DofetilideSolute carrier family 22 member 2transporter
MidodrineAlpha-1A adrenergic receptortarget
MidodrineAlpha-1B adrenergic receptortarget
MidodrineCytochrome P450 2D6enzyme
MidodrineSolute carrier family 15 member 1transporter
MidodrineAlpha-1D adrenergic receptortarget
MilrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
RanolazineCytochrome P450 3A4enzyme
RanolazineCytochrome P450 2D6enzyme
RanolazineBile salt export pumptransporter
RanolazineP-glycoprotein 1transporter
RanolazineSodium channel proteintarget
RanolazineInward rectifier potassium channeltarget
RanolazineVoltage gated L-type calcium channeltarget
RanolazineAlpha-1 adrenergic receptorstarget
RanolazineBeta-1 adrenergic receptortarget
RanolazineFatty acidtarget
RanolazineAlpha-1-acid glycoprotein 1carrier
RanolazineMultidrug and toxin extrusion protein 1transporter
RanolazineMultidrug and toxin extrusion protein 2transporter
DisopyramideSodium channel protein type 5 subunit alphatarget
DisopyramideAlpha-1-acid glycoprotein 1carrier
DisopyramideCytochrome P450 3A4enzyme
DisopyramideMuscarinic acetylcholine receptor M1target
DisopyramideMuscarinic acetylcholine receptor M2target
DisopyramideMuscarinic acetylcholine receptor M3target
DisopyramidePotassium voltage-gated channel subfamily D member 2target
DisopyramidePotassium voltage-gated channel subfamily D member 3target
DisopyramideSolute carrier family 22 member 2transporter
DisopyramideSolute carrier family 22 member 1transporter
DisopyramidePotassium voltage-gated channel subfamily H member 2target
DisopyramideAlpha-1-acid glycoprotein 2target
DisopyramideCytochrome P450 1A2enzyme
IbutilidePotassium voltage-gated channel subfamily H member 6target
IbutilideVoltage-dependent L-type calcium channel subunit beta-1target
IbutilideVoltage-dependent calcium channel gamma-1 subunittarget
IbutilideVoltage-dependent calcium channel subunit alpha-2/delta-1target
IbutilidePotassium voltage-gated channel subfamily H member 2target
IbutilideVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
IbutilidePotassium channel subfamily K member 1target
IbutilidePotassium channel subfamily K member 6target
IbutilideATP-sensitive inward rectifier potassium channel 11target
IbutilidePotassium voltage-gated channel subfamily H member 7target
IndomethacinProstaglandin G/H synthase 1target
IndomethacinProstaglandin G/H synthase 2target
IndomethacinCytochrome P450 2C19enzyme
IndomethacinUDP-glucuronosyltransferase 1-9enzyme
IndomethacinPhospholipase A2, membrane associatedtarget
IndomethacinProstaglandin reductase 2target
IndomethacinLactoylglutathione lyasetarget
IndomethacinProstaglandin D2 receptor 2target
IndomethacinPeroxisome proliferator-activated receptor gammatarget
IndomethacinSerum albumincarrier
IndomethacinCanalicular multispecific organic anion transporter 2transporter
IndomethacinMultidrug resistance-associated protein 4transporter
IndomethacinMultidrug resistance-associated protein 6transporter
IndomethacinP-glycoprotein 1transporter
IndomethacinMultidrug resistance-associated protein 1transporter
IndomethacinSolute carrier organic anion transporter family member 1A2transporter
IndomethacinSolute carrier family 22 member 6transporter
IndomethacinSolute carrier family 22 member 8transporter
IndomethacinCanalicular multispecific organic anion transporter 1transporter
IndomethacinATP-binding cassette sub-family C member 11transporter
IndomethacinSolute carrier family 22 member 11transporter
IndomethacinSodium/bile acid cotransportertransporter
IndomethacinSolute carrier family 22 member 7transporter
IndomethacinCytochrome P450 2C9enzyme
IndomethacinUDP-glucuronosyltransferase 1-1enzyme
IndomethacinLiver carboxylesterase 1enzyme
IndomethacinUDP-glucuronosyltransferase 2B7enzyme
IndomethacinPeroxisome proliferator-activated receptor alphatarget
IndomethacinAldo-keto reductase family 1 member C3target
IndomethacinSolute carrier organic anion transporter family member 1B1transporter
IndomethacinBile salt export pumptransporter
NorepinephrinePhenylalanine-4-hydroxylasetarget
NorepinephrineAlpha-1A adrenergic receptortarget
NorepinephrineAlpha-1B adrenergic receptortarget
NorepinephrineAlpha-1D adrenergic receptortarget
NorepinephrineAlpha-2A adrenergic receptortarget
NorepinephrineAlpha-2B adrenergic receptortarget
NorepinephrineAlpha-2C adrenergic receptortarget
NorepinephrineBeta-1 adrenergic receptortarget
NorepinephrineBeta-2 adrenergic receptortarget
NorepinephrineBeta-3 adrenergic receptortarget
NorepinephrineSolute carrier family 22 member 2transporter
NorepinephrineSolute carrier family 22 member 3transporter
NorepinephrineSolute carrier family 22 member 5transporter
NorepinephrineSolute carrier family 22 member 1transporter
NorepinephrinePOU domain, class 5, transcription factor 1transporter
NorepinephrineSodium-dependent noradrenaline transportertransporter
NorepinephrineSynaptic vesicular amine transportertarget
NorepinephrineChromaffin granule amine transportertarget
MexiletineSodium channel protein type 5 subunit alphatarget
MexiletineCytochrome P450 1A2enzyme
MexiletineCytochrome P450 2D6enzyme
MexiletineCytochrome P450 2B6enzyme
MexiletineCytochrome P450 2E1enzyme
MexiletineCytochrome P450 3A4enzyme
MexiletineAryl hydrocarbon receptortarget
DigoxinSodium/potassium-transporting ATPase subunit alpha-1target
DigoxinCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DigoxinP-glycoprotein 1transporter
DigoxinSolute carrier organic anion transporter family member 4C1transporter
DigoxinBile salt export pumptransporter
DigoxinSolute carrier organic anion transporter family member 1A2transporter
DigoxinOrganic solute transporter subunit alphatransporter
DigoxinOrganic solute transporter subunit betatransporter
DigoxinSolute carrier organic anion transporter family member 1B1transporter
AcetyldigitoxinSodium/potassium-transporting ATPase subunit alpha-1target
MetaraminolAlpha-1A adrenergic receptortarget
AdenosineAdenosine receptor A3target
AdenosineAdenosine deaminaseenzyme
AdenosineAdenosine kinaseenzyme
AdenosineAdenosine receptor A1target
AdenosineAdenosine receptor A2atarget
AdenosineAdenosine receptor A2btarget
AdenosineSolute carrier family 28 member 3transporter
MoricizineSodium channel protein type 5 subunit alphatarget
MethoxamineAlpha-1A adrenergic receptortarget
MethoxamineAlpha-1B adrenergic receptortarget
MethoxamineAlpha-1D adrenergic receptortarget
NitroglycerinAtrial natriuretic peptide receptor 1target
NitroglycerinAldehyde dehydrogenase, mitochondrialenzyme
FenoldopamDopamine D5 receptortarget
FenoldopamDopamine D1 receptortarget
FenoldopamAlpha-2B adrenergic receptortarget
FenoldopamAlpha-2C adrenergic receptortarget
FenoldopamAlpha-2A adrenergic receptortarget
FenoldopamAlpha-1B adrenergic receptortarget
FenoldopamAlpha-1D adrenergic receptortarget
FenoldopamAlpha-1A adrenergic receptortarget
DobutamineBeta-1 adrenergic receptortarget
DobutamineCatechol O-methyltransferaseenzyme
DobutamineBeta-2 adrenergic receptortarget
DobutamineAlpha-1 adrenergic receptorstarget
DobutamineEstrogen receptor alphatarget
Isosorbide dinitrateAtrial natriuretic peptide receptor 1target
Isosorbide dinitrateCytochrome P450 2E1enzyme
QuinidineSodium channel protein type 5 subunit alphatarget
QuinidineAlpha-1-acid glycoprotein 1carrier
QuinidinePotassium voltage-gated channel subfamily H member 2target
QuinidinePotassium channel subfamily K member 1target
QuinidinePotassium channel subfamily K member 6target
QuinidineCytochrome P450 1A2enzyme
QuinidineCytochrome P450 2E1enzyme
QuinidineCytochrome P450 1A1enzyme
QuinidineCytochrome P450 2D6enzyme
QuinidineCytochrome P450 3A4enzyme
QuinidineCytochrome P450 3A7enzyme
QuinidineSolute carrier family 22 member 2transporter
QuinidineSolute carrier family 22 member 1transporter
QuinidineSolute carrier family 22 member 5transporter
QuinidineP-glycoprotein 1transporter
QuinidineSolute carrier organic anion transporter family member 1A2transporter
QuinidineSolute carrier family 22 member 8transporter
QuinidineCanalicular multispecific organic anion transporter 1transporter
QuinidineSolute carrier family 22 member 4transporter
QuinidineSolute carrier organic anion transporter family member 1B1transporter
QuinidineCytochrome P450 2B6enzyme
QuinidineCytochrome P450 2C9enzyme
QuinidineAlpha-1A adrenergic receptortarget
QuinidineAlpha-1B adrenergic receptortarget
QuinidineAlpha-1D adrenergic receptortarget
QuinidineBile salt export pumptransporter
QuinidineCytochrome P450 2C8enzyme
LevosimendanTroponin C, slow skeletal and cardiac musclestarget
LevosimendanATP-sensitive inward rectifier potassium channel 11target
LevosimendanATP-sensitive inward rectifier potassium channel 8target
LevosimendancGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DopamineDopamine D1 receptortarget
DopamineDopamine beta-hydroxylasetarget
DopamineAmine oxidase [flavin-containing] Aenzyme
DopamineAmine oxidase [flavin-containing] Benzyme
DopamineCatechol O-methyltransferaseenzyme
DopamineSolute carrier family 22 member 2transporter
DopamineSolute carrier family 22 member 1transporter
DopamineSolute carrier family 22 member 3transporter
DopamineSolute carrier family 22 member 5transporter
DopaminePOU domain, class 5, transcription factor 1transporter
DopamineDopamine D5 receptortarget
DopamineDopamine D2 receptortarget
DopamineDopamine D3 receptortarget
DopamineDopamine D4 receptortarget
DopamineSodium-dependent dopamine transportertarget
DopamineDopamine beta-hydroxylaseenzyme
Dopamine5-hydroxytryptamine receptor 1Atarget
Dopamine5-hydroxytryptamine receptor 7target
DopamineD(1) dopamine receptortarget
DopamineSodium-dependent noradrenaline transportertarget
DopamineSodium-dependent serotonin transportertarget
Dopamine5-hydroxytryptamine receptor 3Atarget
Dopamine5-hydroxytryptamine receptor 3Btarget
DopamineSuperoxide dismutase [Cu-Zn]target
DopamineSynaptic vesicular amine transportertarget
Isosorbide mononitrateGuanylate cyclase soluble subunit alpha-2target
Isosorbide mononitrateGlutathione S-transferase Mu 1enzyme
Isosorbide mononitrateXanthine dehydrogenase/oxidaseenzyme
Isosorbide mononitrateAlcohol dehydrogenase class-3enzyme
ProcainamideSodium channel protein type 5 subunit alphatarget
ProcainamideDNA (cytosine-5)-methyltransferase 1target
ProcainamideCytochrome P450 2D6enzyme
ProcainamideCholinesteraseenzyme
ProcainamideSolute carrier family 22 member 2transporter
ProcainamideSolute carrier family 22 member 1transporter
ProcainamideSolute carrier family 22 member 3transporter
ProcainamideSolute carrier family 22 member 5transporter
ProcainamideSolute carrier family 22 member 4transporter
ProcainamidePotassium voltage-gated channel subfamily H member 2target
ProcainamideMultidrug and toxin extrusion protein 1transporter
ProcainamideMultidrug and toxin extrusion protein 2transporter
TocainideSodium channel protein type 5 subunit alphatarget
TocainideSerum albumincarrier
TocainideCytochrome P450 1A2enzyme
DeslanosideSodium/potassium-transporting ATPase subunit alpha-1target
OuabainSodium/potassium-transporting ATPase subunit alpha-1target
OuabainSolute carrier organic anion transporter family member 1A2transporter
OuabainSolute carrier family 22 member 8transporter
OuabainSolute carrier organic anion transporter family member 4C1transporter
OuabainSolute carrier organic anion transporter family member 1B3transporter
OuabainSolute carrier organic anion transporter family member 1C1transporter
OuabainSolute carrier organic anion transporter family member 1B1transporter
OuabainSodium/potassium-transporting ATPase subunit alpha-2target
OuabainSodium/potassium-transporting ATPase subunit alpha-3target
ArbutamineBeta-1 adrenergic receptortarget
ArbutamineBeta-2 adrenergic receptortarget
ArbutamineBeta-3 adrenergic receptortarget
AmiodaroneBeta adrenergic receptortarget
AmiodaroneHERG human cardiac K+ channeltarget
AmiodaroneCytochrome P450 2C8enzyme
AmiodaroneCytochrome P450 2C9enzyme
AmiodaroneCytochrome P450 2D6enzyme
AmiodaroneVoltage-dependent T-type calcium channel subunit alpha-1Itarget
AmiodaroneVoltage gated L-type calcium channeltarget
AmiodaroneCytochrome P450 3A4enzyme
AmiodaroneCytochrome P450 1A2enzyme
AmiodaroneCytochrome P450 1A1enzyme
AmiodaroneP-glycoprotein 1transporter
AmiodaroneCytochrome P450 2C19enzyme
AmiodaroneCytochrome P450 2A6enzyme
AmiodaroneThyroid hormone receptortarget
AmiodaronePeroxisome proliferator-activated receptor gammatarget
AmiodaroneBile salt export pumptransporter
AmiodaroneSolute carrier family 22 member 2transporter
AmiodaroneCytochrome P450 2J2enzyme
AmiodaronePeroxisome proliferator-activated receptor alphatarget
AmiodaronePeroxisome proliferator-activated receptor gamma coactivator 1-betatarget
AmiodaroneSerum albumincarrier
PropafenoneSodium channel protein type 5 subunit alphatarget
PropafenonePotassium voltage-gated channel subfamily H member 2target
PropafenoneCytochrome P450 1A2enzyme
PropafenoneCytochrome P450 2D6enzyme
PropafenoneCytochrome P450 3A4enzyme
PropafenoneP-glycoprotein 1transporter
PropafenoneBeta-1 adrenergic receptortarget
PropafenoneBeta-2 adrenergic receptortarget
FlecainideSodium channel protein type 5 subunit alphatarget
FlecainideCytochrome P450 2D6enzyme
FlecainideSodium channel protein type 4 subunit alphatarget
FlecainideCytochrome P450 2C9enzyme
FlecainidePotassium voltage-gated channel subfamily H member 2target
Flecainidealpha1-acid glycoproteincarrier
FlecainideSerum albumincarrier
FlecainideCytochrome P450 1A2enzyme
FlecainideP-glycoprotein 1transporter
FlecainideMultidrug and toxin extrusion protein 1transporter
FlecainideRyanodine receptor 2target
EncainideSodium channel protein type 5 subunit alphatarget
EncainideCytochrome P450 2D6enzyme
MephentermineAlpha adrenergic receptortarget
MephentermineBeta adrenergic receptortarget
DigitoxinSodium/potassium-transporting ATPase subunit alpha-1target
DigitoxinSerum albumincarrier
DigitoxinCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DigitoxinCytochrome P450 3A4enzyme
DigitoxinSolute carrier organic anion transporter family member 1A2transporter
DigitoxinSolute carrier organic anion transporter family member 4C1transporter
DigitoxinP-glycoprotein 1transporter
AjmalineAlpha-1-acid glycoprotein 1carrier
AjmalineSodium channel protein type 5 subunit alphatarget
AmrinoneTumor necrosis factortarget
AmrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AmrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Btarget
AmrinonecAMP-specific 3',5'-cyclic phosphodiesterase 4target
AmrinonecAMP-specific 3',5'-cyclic phosphodiesterase 3target
AprindineAlpha-1-acid glycoprotein 1carrier
AprindineCalmodulintarget
AprindineSodium channel protein type 5 subunit alphatarget
AprindineCytochrome P450 2D6enzyme
Erythrityl tetranitrateAtrial natriuretic peptide receptor 1target
Erythrityl tetranitrateAtrial natriuretic peptide receptor 2target
CamphorCamphor 5-monooxygenasetarget
CamphorTransient receptor potential cation channel subfamily V member 1target
CamphorTransient receptor potential cation channel subfamily V member 3target
CamphorTransient receptor potential cation channel subfamily A member 1target
CamphorTransient receptor potential cation channel subfamily M member 8target
PrenylamineCalmodulintarget
PrenylamineMyosin light chain kinase 2, skeletal/cardiac muscletarget
PrenylamineCytochrome P450 3A4enzyme
DronedaroneAlpha-1A adrenergic receptortarget
DronedaroneBeta-1 adrenergic receptortarget
DronedaroneAlpha-1B adrenergic receptortarget
DronedaroneAlpha-1D adrenergic receptortarget
DronedaroneAlpha-2A adrenergic receptortarget
DronedaroneAlpha-2B adrenergic receptortarget
DronedaroneAlpha-2C adrenergic receptortarget
DronedaronePotassium voltage-gated channel subfamily H member 2target
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Starget
DronedaroneVoltage-dependent L-type calcium channel subunit beta-1target
DronedaroneVoltage-dependent L-type calcium channel subunit beta-2target
DronedaroneVoltage-dependent L-type calcium channel subunit beta-3target
DronedaroneVoltage-dependent L-type calcium channel subunit beta-4target
DronedaroneCytochrome P450 2D6enzyme
DronedaroneCytochrome P450 3A4enzyme
DronedaroneP-glycoprotein 1transporter
DronedaronePotassium channel subfamily K member 2target
DronedaroneSerum albumincarrier
DronedaroneSolute carrier family 22 member 2transporter
DronedaroneSolute carrier family 22 member 1transporter
DronedaroneSolute carrier organic anion transporter family member 1B1transporter
DronedaroneSolute carrier organic anion transporter family member 1B3transporter
DronedaroneSolute carrier family 22 member 8transporter
DronedaroneCytochrome P450 3A5enzyme
DronedaroneCytochrome P450 2J2enzyme
DronedaroneThyroid hormone receptor alphatarget
DronedaroneSodium channel protein type 5 subunit alphatarget
DronedaroneG protein-activated inward rectifier potassium channel 1target
DronedaronePotassium voltage-gated channel subfamily KQT member 1target
DronedaroneInward rectifier potassium channeltarget
DronedaroneSodium/calcium exchanger 1target
DronedaronePotassium voltage-gated channel subfamily D member 3target
EnoximonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
NesiritideAtrial natriuretic peptide receptor 1target
NesiritideAtrial natriuretic peptide receptor 2target
NesiritideAtrial natriuretic peptide receptor 3target
Pentaerythritol tetranitrateHemoglobin subunit alphatarget
Pentaerythritol tetranitrateHemoglobin subunit betatarget
Pentaerythritol tetranitrateGuanylate cyclase soluble subunit alpha-2enzyme
Pentaerythritol tetranitrateFree radicalstarget
Pentaerythritol tetranitrateNitric oxide synthase, endothelialenzyme
Pentaerythritol tetranitrateAldehyde dehydrogenase, mitochondrialenzyme
RegadenosonAdenosine receptor A2atarget
VernakalantCytochrome P450 2D6enzyme
VernakalantSodium channel protein type 5 subunit alphatarget
VernakalantPotassium voltage-gated channel subfamily A member 5target
VernakalantPotassium voltage-gated channel subfamily D member 3target
VernakalantPotassium voltage-gated channel subfamily H member 2target
DroxidopaPhenylalanine-4-hydroxylasetarget
DroxidopaAlpha-1A adrenergic receptortarget
DroxidopaAlpha-1B adrenergic receptortarget
DroxidopaAlpha-1D adrenergic receptortarget
DroxidopaAlpha-2A adrenergic receptortarget
DroxidopaAlpha-2B adrenergic receptortarget
DroxidopaAlpha-2C adrenergic receptortarget
DroxidopaBeta-1 adrenergic receptortarget
DroxidopaBeta-2 adrenergic receptortarget
DroxidopaBeta-3 adrenergic receptortarget
DroxidopaAromatic-L-amino-acid decarboxylaseenzyme
DroxidopaMonocarboxylate transporter 10transporter
DroxidopaSodium-dependent noradrenaline transportertransporter
SparteineCytochrome P450 2D6enzyme
Trimetazidine3-ketoacyl-CoA thiolase, peroxisomaltarget
IvabradineCytochrome P450 3A4enzyme
IvabradinePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2target
NicorandilATP-binding cassette sub-family C member 9target
UbidecarenoneNADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialtarget
UbidecarenoneSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialtarget
UbidecarenoneLow-density lipoprotein receptorcarrier
UbidecarenoneVery low-density lipoprotein receptorcarrier
UbidecarenoneP-glycoprotein 1transporter
Ubidecarenone3-hydroxy-3-methylglutaryl-coenzyme A reductaseenzyme
MolsidomineGuanylate cyclase soluble subunit alpha-2target
MolsidomineGuanylate cyclase soluble subunit alpha-2enzyme
MolsidominecGMP-specific 3',5'-cyclic phosphodiesteraseenzyme
TrapidilPlatelet-derived growth factor receptor betatarget
TrapidilCyclic nucleotide phosphodiesterasetarget
PhosphocreatineGuanidinoacetate N-methyltransferasetarget
PhosphocreatineSodium- and chloride-dependent creatine transporter 1target
PhosphocreatineCreatine kinase M-typetarget
PhosphocreatineCreatine kinase U-type, mitochondrialtarget
PhosphocreatineCreatine kinase S-type, mitochondrialtarget
PhosphocreatineCreatine kinase B-typetarget
XamoterolBeta-1 adrenergic receptortarget
LidocaineSodium channel protein type 5 subunit alphatarget
LidocaineSodium channel protein type 10 subunit alphatarget
LidocaineEpidermal growth factor receptortarget
LidocaineSodium channel protein type 9 subunit alphatarget
LidocaineCytochrome P450 1A2enzyme
LidocaineCytochrome P450 2D6enzyme
LidocaineCytochrome P450 3A4enzyme
LidocaineCytochrome P450 3A5enzyme
LidocaineCytochrome P450 3A7enzyme
LidocaineSolute carrier family 22 member 5transporter
LidocaineP-glycoprotein 1transporter
LidocaineCytochrome P450 2A6enzyme
LidocaineCytochrome P450 2B6enzyme
LidocaineCytochrome P450 2C8enzyme
LidocaineCytochrome P450 2C9enzyme
LidocaineSodium channel protein type 4 subunit alphatarget
LidocaineAlpha-1-acid glycoprotein 1target
LidocaineAlpha-1-acid glycoprotein 2target
PhenylephrineAlpha-1A adrenergic receptortarget
PhenylephrineAlpha-1B adrenergic receptortarget
PhenylephrineAmine oxidase [flavin-containing] Aenzyme
PhenylephrineAlpha-1D adrenergic receptortarget
PhenylephrineCytochrome P450 1A2enzyme
PhenylephrineSulfotransferase 1A3/1A4enzyme
PhenylephrineAmine oxidase [flavin-containing] Benzyme
EpinephrineAlpha-1A adrenergic receptortarget
EpinephrineBeta-1 adrenergic receptortarget
EpinephrineBeta-2 adrenergic receptortarget
EpinephrineSolute carrier family 22 member 2transporter
EpinephrineSolute carrier family 22 member 1transporter
EpinephrineCytochrome P450 2C9enzyme
EpinephrineCytochrome P450 3A4enzyme
EpinephrineAlpha-1B adrenergic receptortarget
EpinephrineAlpha-1D adrenergic receptortarget
EpinephrineAlpha-2A adrenergic receptortarget
EpinephrineAlpha-2B adrenergic receptortarget
EpinephrineTumor necrosis factortarget
EpinephrineCatechol O-methyltransferaseenzyme
EpinephrineMonoamine oxidaseenzyme
AlprostadilProstaglandin E2 receptor EP2 subtypetarget
AlprostadilProstaglandin E2 receptor EP1 subtypetarget
AlprostadilMultidrug resistance-associated protein 5transporter
AlprostadilSolute carrier organic anion transporter family member 2B1transporter
AlprostadilSolute carrier organic anion transporter family member 3A1transporter
AlprostadilMultidrug resistance-associated protein 4transporter
AlprostadilSolute carrier organic anion transporter family member 2A1transporter
AlprostadilProstaglandin D2 receptor 2target
AlprostadilSolute carrier family 22 member 6transporter
IsoprenalineBeta-1 adrenergic receptortarget
IsoprenalineBeta-2 adrenergic receptortarget
IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit alphatarget
IsoprenalineBeta-3 adrenergic receptortarget
IsoprenalineMitogen-activated protein kinase 1target
IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit betatarget
IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit gammatarget
IsoprenalineCytochrome P450 1A1enzyme
IsoprenalineCAMP phosphodiesterasetarget
IsoprenalineSuperoxide dismutase [Cu-Zn]target
EphedrineAlpha-1A adrenergic receptortarget
EphedrineSodium-dependent noradrenaline transportertarget
EphedrineCholinesteraseenzyme
EphedrineSerum albumincarrier
EphedrineBeta-1 adrenergic receptortarget
EphedrineBeta-2 adrenergic receptortarget
EphedrineSynaptic vesicular amine transportertransporter
EphedrineAcetylcholinesteraseenzyme
SynephrineAlpha-1 adrenergic receptorstarget
BretyliumSodium/potassium-transporting ATPase subunit alpha-1target
Angiotensin IIType-1 angiotensin II receptortarget