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Identification
NameLoratadine
Accession NumberDB00455  (APRD00384)
TypeSmall Molecule
GroupsApproved
DescriptionLoratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. [PubChem]
Structure
Thumb
Synonyms
Claritin
Loratadina
Loratadinum
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
LoratadineTablet10 mg/1OralNorthwind Pharmaceuticals, LLC2014-10-27Not applicableUs
Loratadine Allergy ReliefTablet10 mg/1OralClinical Solutions Wholesale2003-08-28Not applicableUs
Loratadine AntihistamineTablet10 mg/1Oralbryant ranch prepack2008-10-15Not applicableUs
Loratadineantihistamine AntihistamineTablet10 mg/1OralREMEDYREPACK INC.2013-05-20Not applicableUs
Loratadineantihistamine AntihistamineTablet10 mg/1OralREMEDYREPACK INC.2014-02-06Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
24 Hour Allergy ReliefTablet10 mg/1OralMeijer Distribution Inc2014-12-30Not applicableUs
24 Hour Allergy RemedyTablet10 mgOralVita Health Products Inc2006-07-28Not applicableCanada
7 Select Allergy ReliefTablet10 mg/1Oral7 Eleven2014-05-14Not applicableUs
Alavert AllergyTablet, orally disintegrating10 mg/1OralPfizer Consumer Healthcare2002-12-19Not applicableUs
Alavert AllergyTablet, orally disintegrating10 mg/1OralPfizer Consumer Healthcare2002-12-19Not applicableUs
Allegy Relief 24 Hour Non DrowsyTablet10 mg/1OralHannaford Brothers Company2006-09-07Not applicableUs
AllergyTablet10 mg/1OralMajor Pharmaceuticals2005-02-21Not applicableUs
Allergy ReliefTablet10 mg/1OralSafeway2013-07-29Not applicableUs
Allergy ReliefSolution5 mg/5mLOralMedicine Shoppe International Inc2004-08-20Not applicableUs
Allergy ReliefTablet10 mg/1OralNovartis Consumer Health, Inc.2010-01-04Not applicableUs
Allergy ReliefTablet, orally disintegrating10 mg/1OralOhm Laboratories Inc.2007-08-31Not applicableUs
Allergy ReliefTablet10 mg/1OralGeri Care Pharmaceutical Corp2008-01-01Not applicableUs
Allergy ReliefTablet10 mg/1OralAllegiant Health2014-12-16Not applicableUs
Allergy ReliefTablet10 mg/1OralKroger Company2005-08-22Not applicableUs
Allergy ReliefTablet, orally disintegrating10 mg/1OralCardinal Health2007-08-31Not applicableUs
Allergy ReliefTablet10 mg/1OralInternational Laboratories, Inc.2016-05-27Not applicableUs
Allergy ReliefSolution5 mg/5mLOralKroger Company2004-08-20Not applicableUs
Allergy ReliefTablet10 mg/1OralShopko Stores Operating Co., LLC2013-09-12Not applicableUs
Allergy ReliefTablet10 mg/1OralMeijer Distribution Inc2007-04-18Not applicableUs
Allergy ReliefTablet10 mg/1OralCVS Pharmacy2005-01-04Not applicableUs
Allergy ReliefTablet10 mg/1OralHy Vee Inc2005-05-23Not applicableUs
Allergy ReliefTablet10 mg/1OralNovartsi Consumer Health, Inc.2010-01-11Not applicableUs
Allergy ReliefTablet10 mg/1OralRite Aid Corporation2004-10-21Not applicableUs
Allergy Relief 24 HourTablet10 mg/1OralWestern Family Foods Inc2005-04-04Not applicableUs
Allergy Relief ChildrensSolution5 mg/5mLOralH E B2004-08-20Not applicableUs
Allergy Relief ChildrensSolution5 mg/5mLOralH E B2010-02-27Not applicableUs
Allergy Relief MedicationTablet10 mg/1OralTarget Brands, Inc.2010-01-31Not applicableUs
Allergy Relief Non DrowsyTablet10 mg/1OralSelect Corporation2012-10-15Not applicableUs
Allergy RemedyTablet10 mgOralApotex Inc2013-05-23Not applicableCanada
AllertinCapsule10 mgOralApotex Inc2013-10-31Not applicableCanada
AllertinTablet10 mgOralApotex IncNot applicableNot applicableCanada
Allertin Tablets 10mgTablet10 mgOralVita Health Products Inc2002-01-012008-08-05Canada
Apo-loratadineTablet10 mgOralApotex Inc2001-06-27Not applicableCanada
Bactimicina AllergyTablet10 mg/1OralDLC Laboratories, Inc.2009-10-21Not applicableUs
Being Well Allergy ReliefTablet10 mg/1OralSave A Lot Food Stores Ltd2006-02-25Not applicableUs
Berkley and Jensen Allergy ReliefTablet10 mg/1OralBJWC2009-04-17Not applicableUs
Berkley and Jensen Loratadine Non DrowsyTablet10 mg/1OralBJWC2009-04-17Not applicableUs
Best Choice Childrens LoratadineSolution5 mg/5mLOralValu Merchandisers Company2004-08-20Not applicableUs
Best Choice Childrens Loratadine Sugar FreeSolution5 mg/5mLOralValu Merchandisers Company2010-02-27Not applicableUs
Care One Childrens LoratadineSolution5 mg/5mLOralAmerican Sales Company2010-02-27Not applicableUs
Careone Allergy Relief 24 HourTablet10 mg/1OralAmerican Sales Company2006-06-02Not applicableUs
Children Claritin AllergySolution5 mg/5mLOralBayer Health Care Consumer Care2015-05-26Not applicableUs
Childrens 24 Hour AllergySolution5 mg/5mLOralMeijer Distribution Inc2004-08-20Not applicableUs
Childrens AllergyLiquid5 mg/5mLOralDolgencorp, Inc. (Dollar General & Rexall)2016-02-29Not applicableUs
Childrens AllergySolution5 mg/5mLOralPublix Super Markets Inc2010-02-27Not applicableUs
Childrens Allergy Dye FreeLiquid5 mg/5mLOralTarget Corporation2014-10-31Not applicableUs
Childrens Allergy Dye FreeLiquid5 mg/5mLOralQUALITY CHOICE (Chain Drug Marketing Association)2015-01-31Not applicableUs
Childrens Allergy ReliefSolution5 mg/5mLOralCVS Pharmacy2004-08-20Not applicableUs
Childrens Allergy ReliefSolution5 mg/5mLOralWal Mart Stores Inc2004-08-20Not applicableUs
Childrens Allergy ReliefSolution5 mg/5mLOralRite Aid Corporation2010-02-27Not applicableUs
Childrens Allergy ReliefSolution5 mg/5mLOralSupervalu Inc2004-08-20Not applicableUs
Childrens Allergy ReliefSolution5 mg/5mLOralRite Aid Corporation2004-08-20Not applicableUs
Childrens Allergy ReliefSolution5 mg/5mLOralCVS Pharmacy2010-02-27Not applicableUs
Childrens LoratadineSolution5 mg/5mLOralTaro Pharmaceuticals U.S.A., Inc.2010-02-27Not applicableUs
Childrens LoratadineSolution5 mg/5mLOralRite Aid Corporation2004-08-20Not applicableUs
Childrens LoratadineSolution5 mg/5mLOralKinray, Inc.2004-08-20Not applicableUs
Childrens LoratadineSolution5 mg/5mLOralTarget Corporation2004-08-20Not applicableUs
Childrens LoratadineSolution5 mg/5mLOralTaro Pharmaceuticals U.S.A., Inc.2004-08-20Not applicableUs
Childrens LoratadineSolution5 mg/5mLOralAidarex Pharmaceuticals LLC2004-08-20Not applicableUs
Childrens LoratadineSolution5 mg/5mLOralTaro Pharmaceuticals U.S.A., Inc.2004-08-20Not applicableUs
Childrens LoratadineSolution5 mg/5mLOralTarget Corporation2010-02-27Not applicableUs
Childrens LoratadineSolution5 mg/5mLOralAmerican Sales Company2004-08-20Not applicableUs
Childrens Non-drowsy 24-hour Allergy ReliefSolution5 mg/5mLOralSafeway Inc.2010-02-27Not applicableUs
Childrens Non-drowsy 24-hour Allergy ReliefSolution5 mg/5mLOralSafeway Inc.2004-08-20Not applicableUs
Childrens Non-drowsy Allergy Relief 24-hourSolution5 mg/5mLOralKroger Company2010-02-27Not applicableUs
Childrens Wal-itinSolution5 mg/5mLOralWalgreen Company2010-02-27Not applicableUs
ClaritinSolution5 mg/5mLOralBayer Health Care Llc2011-03-01Not applicableUs
ClaritinTablet10 mg/1OralMSD Consumer Care, Inc.1993-04-12Not applicableUs
ClaritinTablet10 mg/1OralMSD Consumer Care, Inc.1993-04-12Not applicableUs
ClaritinTablet10 mgOralBayer Inc Consumer Care1988-12-18Not applicableCanada
ClaritinTablet, chewable5 mg/1OralMSD Consumer Care, Inc.2009-03-05Not applicableUs
ClaritinTablet10 mg/1OralNavajo Manufacturing Company Inc.2016-09-17Not applicableUs
ClaritinTablet10 mg/1OralMSD Consumer Care, Inc.1993-04-12Not applicableUs
ClaritinTablet10 mg/1OralMSD Consumer Care, Inc.1993-04-12Not applicableUs
ClaritinTablet, chewable5 mg/1OralMSD Consumer Care, Inc.2006-08-23Not applicableUs
ClaritinTablet, chewable5 mg/5mgOralBayer Health Care Llc2015-09-25Not applicableUs
ClaritinTablet10 mg/1OralMSD Consumer Care, Inc.1993-04-12Not applicableUs
Claritin AntihistamineTablet10 mg/1OralLil' Drug Store Products, Inc2004-11-23Not applicableUs
Claritin KidsSyrup1 mgOralBayer Inc Consumer Care2000-04-06Not applicableCanada
Claritin Liqui-gelsCapsule, liquid filled10 mg/1OralMSD Consumer Care, Inc.2008-06-16Not applicableUs
Claritin Liquid CapsulesCapsule10 mgOralBayer Inc Consumer Care2013-07-01Not applicableCanada
Claritin Rapid DissolveTablet, orally disintegrating5 mgOralBayer Inc Consumer CareNot applicableNot applicableCanada
Claritin Rapid DissolveTablet, orally disintegrating10 mgOralBayer Inc Consumer Care1998-05-05Not applicableCanada
Claritin ReditabsTablet, orally disintegrating10 mg/1OralBayer HealthCare LLC2002-11-27Not applicableUs
Claritin ReditabsTablet, orally disintegrating5 mg/1OralMSD Consumer Care, Inc.2006-12-12Not applicableUs
Claritin ReditabsTablet, orally disintegrating10 mg/1OralBayer HealthCare LLC2002-11-27Not applicableUs
Claritin Syrup 1mg/mlSyrup1 mgOralSchering Plough Canada Inc1993-12-312012-07-24Canada
CleartimeTablet10 mg/1OralHy Vee Inc2015-02-16Not applicableUs
CleartimeTablet10 mg/1OralWestern Family Foods Inc2015-03-04Not applicableUs
Counteract AllergyTablet10 mg/1OralMelaleuca, Inc.2008-06-28Not applicableUs
Dg Health Allergy ReliefTablet10 mg/1OralDolgencorp, LLC2012-04-13Not applicableUs
Equaline Allergy ReliefTablet10 mg/1OralSupervalu Inc2005-02-07Not applicableUs
Equaline Allergy Relief Non DrowsyTablet, orally disintegrating10 mg/1OralSupervalu Inc2004-08-05Not applicableUs
Equaline Childrens LoratadineSolution5 mg/5mLOralSupervalu Inc2010-02-27Not applicableUs
Equate Allergy ReliefTablet10 mg/1OralWal Mart Stores Inc2007-04-27Not applicableUs
Equate Childrens Allergy ReliefSolution5 mg/5mLOralWal Mart Stores Inc2010-02-27Not applicableUs
Exchange Select Allergy ReliefTablet10 mg/1OralArmy & Air Force Exchange Service2008-08-26Not applicableUs
Fad First Aid Direct Allergy ReliefTablet10 mg/1OralFirst Aid Direct2012-12-19Not applicableUs
Family Dollar Allergy ReliefTablet10 mg/1OralNovartis Consumer Health, Inc.2004-09-30Not applicableUs
Family Wellness Allergy ReliefTablet10 mg/1OralFamily Dollar Services Inc2016-06-14Not applicableUs
Formucare Allergy ReliefTablet10 mg/1OralAccess Business Group LLC2005-01-27Not applicableUs
Good Neighbor Pharmacy Allergy ReliefTablet, orally disintegrating10 mg/1OralAmerisource Bergen2004-03-15Not applicableUs
Good Neighbor Pharmacy Childrens LoratadineSolution5 mg/5mLOralAmerisource Bergen2010-02-27Not applicableUs
Good Neighbor Pharmacy Childrens LoratadineSolution5 mg/5mLOralAmerisource Bergen2004-08-20Not applicableUs
Good Neighbor Pharmacy Childrens LoratadineSolution5 mg/5mLOralAmerisource Bergen2004-08-20Not applicableUs
Good Neighbor Pharmacy CleartimeTablet10 mg/1OralAmerisource Bergen2015-03-25Not applicableUs
Good Neighbor Pharmacy LoratadineTablet10 mg/1OralAmerisource Bergen2008-11-10Not applicableUs
Good Sense Allergy ReliefTablet10 mg/1OralL. Perrigo Company2004-09-21Not applicableUs
Good Sense Childrens LoratadineSolution5 mg/5mLOralGeiss, Destin & Dunn, Inc.2010-02-27Not applicableUs
Handy Solutions 24 Hour AllergyTablet10 mg/1OralNavajo Manufacturing Company Inc.2016-09-22Not applicableUs
Harmon Face Values Allergy ReliefTablet10 mg/1OralHarmon Stores Inc.2011-12-18Not applicableUs
Harris Teeter Allergy ReliefTablet10 mg/1OralHarris Teeter, LLC2015-06-24Not applicableUs
Health Mart Allergy ReliefTablet10 mg/1OralMc Kesson2012-01-13Not applicableUs
Health Mart LoratadineTablet10 mg/1OralMc Kesson2014-10-02Not applicableUs
Health Mart Pharmacy Childrens LoratadineSolution5 mg/5mLOralHealth Mart2004-08-20Not applicableUs
Healthmart Childrens LoratadineSolution5 mg/5mLOralMc Kesson2010-02-27Not applicableUs
Healthmart Loratadine ODTTablet, orally disintegrating10 mg/1OralHealth Mart2007-08-31Not applicableUs
Healthy Accents Allergy ReliefTablet10 mg/1OralDZA Brands LLC2007-12-15Not applicableUs
Hy-vee Childrens LoratadineSolution5 mg/5mLOralHyVee Inc2010-02-27Not applicableUs
Kirkland Signature AllerclearTablet10 mg/1OralCostco Wholesale Company2007-05-22Not applicableUs
Leader Allergy ReliefTablet, orally disintegrating10 mg/1OralCardinal Health2004-02-25Not applicableUs
Leader Allergy ReliefTablet10 mg/1OralCardinal Health2014-07-02Not applicableUs
Leader Allergy ReliefTablet, orally disintegrating10 mg/1OralCardinal Health2004-02-25Not applicableUs
Leader Childrens Allergy ReliefSolution5 mg/5mLOralCardinal Health2004-08-20Not applicableUs
Leader LoratadineTablet10 mg/1OralCardinal Health2003-08-19Not applicableUs
Live Better LoratadineSolution5 mg/5mLOralThe Great Atlantic & Pacific Tea Company2010-02-27Not applicableUs
LoratadineTablet10 mg/1OralCardinal Health2003-01-212015-12-29Us
LoratadineTablet10 mg/1OralMajor Pharmaceuticals2016-06-22Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralWalgreen Company2007-08-31Not applicableUs
LoratadineTablet10 mg/1OralCardinal Health2011-06-03Not applicableUs
LoratadineTablet10 mg/1OralFamily Dollar Services, Inc.2003-08-19Not applicableUs
LoratadineTablet10 mg/1OralDIRECT RX2014-01-01Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralGood Neighbor Pharmacy2007-08-31Not applicableUs
LoratadineTablet10 mg/1OralHealth Mart2016-06-01Not applicableUs
LoratadineTablet10 mg/1OralShopko Stores Operating Co., LLC2003-08-19Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralSUPERVALU INC.2013-12-03Not applicableUs
LoratadineTablet10 mg/1OralMylan Institutional Inc.2013-04-30Not applicableUs
LoratadineTablet10 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-01-21Not applicableUs
LoratadineSolution5 mg/5mLOralSilarx Pharmaceuticals, Inc2010-11-24Not applicableUs
LoratadineTablet10 mg/1OralApotex Corp.2005-01-24Not applicableUs
LoratadineTablet10 mg/1OralChain Drug Marketing Association Inc.2003-08-19Not applicableUs
LoratadineTablet10 mg/1OralPremier Value2003-08-19Not applicableUs
LoratadineTablet10 mg/1OralDLC Laboratories, Inc2009-06-06Not applicableUs
LoratadineTablet10 mg/1OralSunmark2016-06-01Not applicableUs
LoratadineTablet10 mg/1OralMajor Pharmaceuticals2003-08-28Not applicableUs
LoratadineSolution5 mg/5mLOralCardinal Health2004-08-20Not applicableUs
LoratadineTablet10 mg/1OralNorthstar Rx LLC2016-02-01Not applicableUs
LoratadineSolution5 mg/5mLOralAtlantic Biologicals Corps2011-02-17Not applicableUs
LoratadineTablet10 mg/1OralBlenheim Pharmacal, Inc.2014-02-09Not applicableUs
LoratadineTablet10 mg/1OralSandoz Inc2003-01-21Not applicableUs
LoratadineSolution5 mg/5mLOralSilarx Pharmaceuticals, Inc2010-11-24Not applicableUs
LoratadineTablet10 mg/1OralNovartis Consumer Health, Inc.2004-09-30Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralAmerican Sales Company2007-08-31Not applicableUs
LoratadineTablet10 mg/1OralMylan Pharmaceuticals Inc.2013-03-27Not applicableUs
LoratadineTablet10 mg/1OralMedline Industries, Inc.2003-08-19Not applicableUs
LoratadineTablet10 mg/1OralFred's Inc.2003-08-19Not applicableUs
LoratadineTablet10 mg/1OralKinray2003-08-19Not applicableUs
LoratadineTablet10 mgOralApotex Inc2013-04-18Not applicableCanada
LoratadineTablet, orally disintegrating10 mg/1OralGood Neighbor Pharmacy2007-08-31Not applicableUs
LoratadineTablet10 mg/1OralKAISER FOUNDATION HOSPITALS2011-02-23Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralGood Neighbor Pharmacy2007-08-31Not applicableUs
LoratadineSolution5 mg/5mLOralMajor Pharmaceuticals, Inc2011-02-17Not applicableUs
LoratadineTablet10 mg/1OralCardinal Health2009-11-19Not applicableUs
LoratadineTablet10 mg/1OralInnovative Manufacturing and Distribution Services, Inc.2008-12-01Not applicableUs
LoratadineTablet10 mg/1OralSafeway Inc.2009-06-06Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralTarget Corporation2007-08-31Not applicableUs
LoratadineTablet10 mg/1OralCVS Pharmacy2010-01-08Not applicableUs
LoratadineSolution5 mg/5mLOralRebel Distributors Corp2004-08-20Not applicableUs
LoratadineCapsule, liquid filled10 mg/1OralMARKSANS PHARMA LIMITED2016-10-01Not applicableUs
LoratadineTablet10 mgOralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
LoratadineTablet10 mg/1OralOhm Laboratories Inc.2009-06-23Not applicableUs
LoratadineTablet10 mg/1OralPhysicians Total Care, Inc.2005-04-18Not applicableUs
LoratadineTablet10 mg/1OralValu Merchandisers Company2003-08-19Not applicableUs
LoratadineTablet10 mg/1OralSelect Brand2003-08-19Not applicableUs
LoratadineCapsule, liquid filled10 mg/1OralTime Cap Laboratories Inc2016-10-13Not applicableUs
LoratadineTablet10 mg/1OralNovartis Consumer Health, Inc.2004-09-30Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralAmerican Sales Company2007-08-31Not applicableUs
LoratadineTablet10 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralChain Drug Marketing Association Inc.2007-08-31Not applicableUs
LoratadineTablet10 mg/1OralCardinal Health2013-04-30Not applicableUs
LoratadineTablet10 mg/1OralRugby Laboratories2016-06-22Not applicableUs
LoratadineTablet10 mg/1OralWalgreen Company2013-12-05Not applicableUs
LoratadineTablet10 mg/1OralAmerisource Bergen2003-08-19Not applicableUs
LoratadineTablet10 mg/1OralCardinal Health2005-01-24Not applicableUs
LoratadineTablet10 mg/1OralMc Kesson Contract Packaging2011-09-26Not applicableUs
LoratadineTablet10 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-02-23Not applicableUs
LoratadineTablet10 mg/1OralH.J. Harkins Company, Inc.2008-10-15Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralTarget Corporation2007-08-31Not applicableUs
LoratadineTablet10 mg/1OralAv Pak2016-03-11Not applicableUs
LoratadineTablet10 mg/1OralWal Mart2016-06-30Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralTopcare Associates LLC2007-08-31Not applicableUs
LoratadineSolution5 mg/5mLOralPhysicians Total Care, Inc.2006-04-28Not applicableUs
LoratadineTablet10 mg/1OralPublix Super Markets Inc2003-08-19Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralValu Merchandisers Company2007-08-31Not applicableUs
LoratadineSolution5 mg/5mLOralPreferred Pharmaceuticals, Inc.2012-05-09Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralSelect Brand2007-08-31Not applicableUs
LoratadineSolution5 mg/5mLOralCardinal Health2004-08-20Not applicableUs
LoratadineTablet10 mg/1OralAmerican Health Packaging2008-01-08Not applicableUs
LoratadineTablet10 mg/1OralSUPERVALU INC.2003-08-19Not applicableUs
LoratadineTablet, orally disintegrating10 mg/1OralAmerican Sales Company2007-08-31Not applicableUs
Loratadine Allergy ReliefTablet10 mg/1OralWin Co Foods, Llc2003-08-28Not applicableUs
Loratadine Allergy ReliefTablet10 mg/1OralWin Co Foods, Llc2003-08-28Not applicableUs
Loratadine Allergy ReliefTablet10 mg/1OralProficient Rx LP2003-08-28Not applicableUs
Loratadine Allergy ReliefTablet10 mg/1OralOhm Laboratories Inc.2003-08-28Not applicableUs
Loratadine AntihistamineTablet10 mg/1OralProficient Rx LP2008-10-15Not applicableUs
Loratadine AntihistamineTablet10 mg/1OralUnit Dose Services2008-10-15Not applicableUs
Loratadine AntihistamineTablet10 mg/1OralPerrigo New York Inc2008-10-15Not applicableUs
Loratadine AntihistamineTablet10 mg/1OralCardinal Health2008-10-15Not applicableUs
Loratadine AntihistamineTablet10 mg/1OralUnit Dose Services2008-10-15Not applicableUs
Loratadine AntihistamineTablet10 mg/1OralREMEDYREPACK INC.2016-11-14Not applicableUs
Loratadine AntihistamineTablet10 mg/1OralPreferred Pharmaceuticals, Inc.2008-10-15Not applicableUs
Loratadine AntihistamineTablet10 mg/1OralLake Erie Medical DBA Quality Care Products LLC2008-10-15Not applicableUs
Loratadine AntihistamineTablet10 mg/1OralREMEDYREPACK INC.2016-07-08Not applicableUs
Loratadine ODTablet, orally disintegrating10 mg/1OralFred's Inc.2007-08-31Not applicableUs
Loratadine ODTTablet, orally disintegrating10 mg/1OralTopco Associates LLC2007-08-31Not applicableUs
Loratadine ODTTablet, orally disintegrating10 mg/1OralMeijer Distribution, Inc.2007-08-31Not applicableUs
Loratadine ODTTablet, orally disintegrating10 mg/1OralCVS Pharmacy2007-09-27Not applicableUs
Loratadine ODTTablet, orally disintegrating10 mg/1OralShopko Stores Operating Co., LLC2007-08-31Not applicableUs
Loratadine ODTTablet, orally disintegrating10 mg/1OralChain Drug Consortium, LLC2007-08-31Not applicableUs
Loratadine ODTTablet, orally disintegrating10 mg/1OralMeijer Distribution, Inc.2007-08-31Not applicableUs
Loratadine ODTTablet, orally disintegrating10 mg/1OralSafeway Inc.2007-08-31Not applicableUs
Loratadine ODTTablet, orally disintegrating10 mg/1OralMajor Pharmaceuticals2007-08-31Not applicableUs
Loratadine Soft Gel CapsuleCapsule10 mgOralApotex Inc2012-09-07Not applicableCanada
Loratadine Tablets 10mgTablet10 mgOralVita Health Products Inc2002-01-012008-08-05Canada
Loratadineantihistamine AntihistamineTablet10 mg/1OralREMEDYREPACK INC.2013-05-282016-10-13Us
Medicine Shoppe Loratadine Allergy ReliefTablet10 mg/1OralThe Medicine Shoppe International2003-08-19Not applicableUs
Medique LoradamedTablet, film coated10 mg/1OralUnifirst First Aid Corporation2008-12-30Not applicableUs
Meijer Childrens 24 Hour AllergySolution5 mg/5mLOralMeijer Distribution Inc2010-02-27Not applicableUs
Members Mark LoratadineTablet10 mg/1OralSam's West Inc2007-05-21Not applicableUs
Moore Medical LoratadineTablet, film coated10 mg/1OralMoore Medical LLC2008-12-30Not applicableUs
Novo-loratadineTablet10 mgOralNovopharm LimitedNot applicableNot applicableCanada
Preferred Plus (kinray) Childrens LoratadineSolution5 mg/5mLOralPreferred Plus (Kinray)2010-02-27Not applicableUs
Preferred Plus Allergy ReliefTablet10 mg/1OralKinray2014-09-22Not applicableUs
Premier Value Childrens LoratadineSolution5 mg/5mLOralChain Drug Constortium2004-08-20Not applicableUs
Premier Value Childrens LoratadineSolution5 mg/5mLOralChain Drug Constortium2010-02-27Not applicableUs
Quality Choice Childrens Allergy ReliefSolution5 mg/5mLOralChain Drug Marketing Association2004-08-20Not applicableUs
Quality Choice Childrens Allergy ReliefSolution5 mg/5mLOralChain Drug Marketing Association, Inc.2010-02-27Not applicableUs
Rexall Allergy Relief Non DrowsyTablet10 mg/1OralDolgencorp, LLC2010-08-22Not applicableUs
Shoprite Allergy ReliefTablet10 mg/1OralWakefern Food Corporation2013-08-06Not applicableUs
Signature Care Allergy ReliefTablet10 mg/1OralSafeway2016-02-08Not applicableUs
Simply Right LoratadineTablet10 mg/1OralSam's West Inc2014-01-03Not applicableUs
Smart Sense Allergy Relief Non DrowsyTablet10 mg/1OralKmart Corporation2010-11-24Not applicableUs
Sound Body Allergy ReliefTablet10 mg/1OralBig Lots Stores, Inc.2015-06-12Not applicableUs
Sunmark Allergy ReliefTablet, orally disintegrating10 mg/1OralMc Kesson2004-02-02Not applicableUs
Sunmark Childrens LoratadineSolution5 mg/5mLOralMc Kesson2004-08-20Not applicableUs
Sunmark Childrens LoratadineSolution5 mg/5mLOralMc Kesson2010-02-27Not applicableUs
Sunmark Childrens LoratadineSolution5 mg/5mLOralMc Kesson2004-08-20Not applicableUs
Sunmark LoratadineTablet10 mg/1OralMc Kesson2007-06-21Not applicableUs
Sunmark Loratadine Allergy ReliefTablet, orally disintegrating10 mg/1OralMc Kesson2004-02-02Not applicableUs
Sunmark Loratadine ODTTablet, orally disintegrating10 mg/1OralSunmark2007-08-31Not applicableUs
Sunmark Loratadine ODTTablet, orally disintegrating10 mg/1OralSunmark2007-08-31Not applicableUs
Taro-loratadineTablet10 mgOralTaro Pharmaceuticals IncNot applicableNot applicableCanada
Topcare Allergy ReliefTablet, orally disintegrating10 mg/1OralTopco Associates LLC2004-02-032016-10-29Us
Topcare Allergy ReliefTablet, orally disintegrating10 mg/1OralTopco Associates LLC2004-03-092016-11-08Us
Topcare Allergy Relief 24 HourTablet10 mg/1OralTopco Associates LLC2005-01-25Not applicableUs
Topcare Childrens Allergy Relief 24 Hour Non DrowsyTablet, orally disintegrating10 mg/1OralTopco Associates LLC2005-03-022016-10-29Us
Topcare Childrens LoratadineSolution5 mg/5mLOralTopco Associates LLC2010-02-27Not applicableUs
Topcare Clear TimeTablet10 mg/1OralTopco Associates LLC2015-01-13Not applicableUs
Up and Up Allergy ReliefTablet, orally disintegrating10 mg/1OralTarget Corporation2009-06-16Not applicableUs
Up and Up Allergy ReliefTablet10 mg/1OralTarget Corporation2012-03-26Not applicableUs
Vicks Qlearquil All Day and All Night 24 Hour Allergy ReliefTablet10 mg/1OralThe Procter & Gamble Manufacturing Company2014-03-01Not applicableUs
Wal ItinTablet10 mg/1OralWalgreen Company2009-02-13Not applicableUs
Wal ItinTablet10 mg/1OralWalgreen Company2009-02-13Not applicableUs
Wal-itin Allergy ReliefSolution5 mg/5mLOralWalgreen Company2004-08-20Not applicableUs
Welby Health Allergy ReliefTablet10 mg/1OralAldi, Inc2007-04-12Not applicableUs
Western Family Childrens Allergy ReliefSolution5 mg/5mLOralWestern Family Foods Inc2010-02-27Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Help I Have AllergiesTablet10 mg/1OralHelp Remedies, Inc.2009-07-01Not applicableUs
LoratadineTablet10 mg/1OralRebel Distributors Corp2010-01-21Not applicableUs
LoratadineTablet10 mg/1OralCardinal Health2013-06-14Not applicableUs
International Brands
NameCompany
AerotinaNot Available
AlavertNot Available
BiloinaNot Available
CiveranNot Available
FristaminNot Available
HistaloranNot Available
LomilanNot Available
LoracertNot Available
LoradexNot Available
LoranoxNot Available
LorastineNot Available
LoratyneNot Available
LoritineNot Available
NularefNot Available
RestamineNot Available
RoletraNot Available
SensibitNot Available
Brand mixtures
NameLabellerIngredients
Alavert Allergy Sinus D-12Wyeth Consumer Healthcare
Allerclear-D 24 HourCostco Wholesale Corporation
Allergy and Congestion ReliefL. Perrigo Company
Allergy and Congestion Relief Non DrowsyAmerisource Bergen
Allergy Relief DShopko Stores Operating Co., LLC
Allergy Relief D 12CVS Pharmacy
Allergy Relief D 12 HourPublix Super Markets Inc
Allergy Relief D 24 HourPublix Super Markets Inc
Allergy Relief-DCVS Pharmacy
Allergy Relief-D 24 HourShopko Stores Operating Co., LLC
Allergy Relief-d24 Hour 24 HourTopco Associates LLC
Careone Allergy and Congestion ReliefAmerican Sales Company
Chlor-tripolon Nd SrtSchering Plough Canada Inc
Claritin Allergy + SinusBayer Inc Consumer Care
Claritin Allergy + Sinus Extra StrengthBayer Inc Consumer Care
Claritin-D 12 HourMSD Consumer Care, Inc.
Claritin-D 24 HourMSD Consumer Care, Inc.
Equaline Allergy and Congestion ReliefSupervalu Inc
Good Neighbor Pharmacy Loratadine DAmerisource Bergen
Good Neighbor Pharmacy Loratadine D 24 HourAmerisource Bergen
Good Sense Allergy and Congestion ReliefL Perrigo Company
Good Sense Allergy and Congestion Relief Non Drowsy 24 HourL Perrigo Company
Harris Teeter Allergy and Congestion ReliefHarris Teeter, LLC
Health Mart Allergy and CongestionMc Kesson
Healthy Accents Allergy and Congestion Relief 24 Hour Non DrowsyDZA Brands LLC
Kirkland Signature Allerclear D 12 HrCostco Wholesale Company
Kirkland Signature Allerclear D 24hrCostco Wholesale Company
Leader Allergy Relief D-24Cardinal Health
LiberatorSchering Plough Canada Inc
Loratadine and PseudoephedrineWalgreen Company
Loratadine and Pseudoephedrine SulfateMajor Pharmaceuticals
Loratadine Dbryant ranch prepack
Loratadine D 24 HourPerrigo New York Inc
Medicine Shoppe Allergy Relief D24The Medicine Shoppe International
Preferred Plus Allergy and Congestion ReliefKinray
Shoprite Allergy and Congestion ReliefWakefern Food Corporation
Signature Care Allergy and Congestion ReliefSafeway
Smart Sense Allergy and Congestion ReliefKmart Corporation
Smart Sense Allergy and Congestion Relief DKmart Corporation
Smart Sense Allergy and Congestion Relief Indoor and Outdoor AllergiesKmart Corporation
Smart Sense Allergy and Congestion Relief-DKmart Corporation
Sunmark Loratadine DMc Kesson
Topcare Allergy Relief DTopco Associates LLC
Up and Up Allergy and Congestion ReliefTarget Corporation
Up and Up Allergy Plus Congestion Relief DTarget Corporation
Wal Itin DWalgreen Company
Wal Itin D 12 Hour Allergy and CongestionWalgreen Company
Wal Itin D Non DrowsyWalgreen Company
Wal Itin D Non Drowsy 24 Hour Allergy and CongestionWalgreen Company
Wal-itin D 24 HourWalgreen Company
SaltsNot Available
Categories
UNII7AJO3BO7QN
CAS number79794-75-5
WeightAverage: 382.883
Monoisotopic: 382.144805697
Chemical FormulaC22H23ClN2O2
InChI KeyJCCNYMKQOSZNPW-UHFFFAOYSA-N
InChI
InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
IUPAC Name
ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidine-1-carboxylate
SMILES
CCOC(=O)N1CCC(CC1)=C1C2=C(CCC3=C1N=CC=C3)C=C(Cl)C=C2
Pharmacology
IndicationA self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian).
Structured Indications
PharmacodynamicsLoratadine is a long acting second generation antihistamine that is similar in structure to cyproheptadine and azatadine. The pharmacology of loratadine is similar to other antihistamines, but unlike other H1-blockers, loratidine is shown to exhibit competitive, specific, and selective antagonism of H1 receptors. The exact mechanism of this interaction is unknown, but disposition of the drug suggests that loratadine's prolonged antagonism of histamine may be due to the drug's slow dissociation from the receptor or the formation of the active metabolite, desloratadine. Loratadine does not penetrate the CNS effectively and has a low affinity for CNS H1-receptors.
Mechanism of actionLoratadine competes with free histamine and exhibits specific, selective peripheral H1 antagonistic activity. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Loratadine has low affinity for cholinergic receptors and does not exhibit any appreciable alpha-adrenergic blocking activity in-vitro. Loratadine also appears to suppress the release of histamine and leukotrienes from animal mast cells, and the release of leukotrienes from human lung fragments, although the clinical importance of this is unknown.
TargetKindPharmacological actionActionsOrganismUniProt ID
Histamine H1 receptorProteinyes
antagonist
HumanP35367 details
Related Articles
AbsorptionRapidly absorbed following oral administration (40% bioavailability)
Volume of distributionNot Available
Protein binding97-99%
Metabolism

Hepatic

SubstrateEnzymesProduct
Loratadine
DescarboethoxyloratadineDetails
Route of eliminationNot Available
Half life8.4 hours
ClearanceNot Available
Toxicitysomnolence, tachycardia, and headache LD50=mg/kg (orally in rat)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Loratadine is combined with 1,1,1,2 Tetrafluoroethane.Investigational
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Loratadine.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Loratadine.Experimental, Illicit
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Loratadine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Loratadine.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Loratadine.Experimental
AbirateroneThe serum concentration of Loratadine can be increased when it is combined with Abiraterone.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Loratadine.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Loratadine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Loratadine.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Loratadine.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Loratadine.Approved, Vet Approved
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Loratadine.Investigational
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Loratadine.Approved
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Loratadine.Approved, Investigational
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Loratadine.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Loratadine.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Loratadine.Approved, Illicit
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Loratadine.Approved, Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Loratadine.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Loratadine.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Loratadine.Approved, Investigational
AmiodaroneThe serum concentration of Loratadine can be increased when it is combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Loratadine.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Loratadine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Loratadine.Approved, Illicit
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Loratadine.Approved
AmoxapineThe risk or severity of adverse effects can be increased when Loratadine is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Loratadine.Experimental
AmphetamineAmphetamine may decrease the sedative activities of Loratadine.Approved, Illicit
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Loratadine.Approved
AprepitantThe serum concentration of Loratadine can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Loratadine.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Loratadine.Approved, Investigational
ArtemetherThe metabolism of Loratadine can be decreased when combined with Artemether.Approved
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Loratadine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Loratadine.Approved
AtazanavirThe metabolism of Loratadine can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Loratadine.Approved
AtomoxetineThe metabolism of Loratadine can be decreased when combined with Atomoxetine.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Loratadine.Approved, Investigational
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Loratadine.Vet Approved
AzelastineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Loratadine is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Loratadine.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Loratadine.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Loratadine is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Loratadine.Approved
BenzphetamineBenzphetamine may decrease the sedative activities of Loratadine.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Loratadine.Approved
Benzylpenicilloyl PolylysineLoratadine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Loratadine.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Loratadine.Approved, Vet Approved
BetaxololThe metabolism of Loratadine can be decreased when combined with Betaxolol.Approved
BexaroteneThe serum concentration of Loratadine can be decreased when it is combined with Bexarotene.Approved, Investigational
BoceprevirThe metabolism of Loratadine can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Loratadine can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Loratadine can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Loratadine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Loratadine.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Loratadine is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Loratadine is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Loratadine.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Loratadine.Approved, Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Loratadine is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Loratadine.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Loratadine.Approved, Investigational
BuprenorphineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Loratadine can be decreased when combined with Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Loratadine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Loratadine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Loratadine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Loratadine.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Loratadine.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Loratadine.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Loratadine.Approved, Illicit, Vet Approved
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Loratadine.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Loratadine.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Loratadine.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Loratadine.Approved
CapecitabineThe metabolism of Loratadine can be decreased when combined with Capecitabine.Approved, Investigational
CarbamazepineThe metabolism of Loratadine can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Loratadine is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Loratadine.Illicit, Vet Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Loratadine.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Loratadine.Approved
CelecoxibThe metabolism of Loratadine can be decreased when combined with Celecoxib.Approved, Investigational
CeritinibThe serum concentration of Loratadine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Loratadine.Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Loratadine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Loratadine.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Loratadine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Loratadine.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Loratadine.Approved
ChloroquineThe metabolism of Loratadine can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Loratadine is combined with Chlorphenamine.Approved
ChlorphentermineChlorphentermine may decrease the sedative activities of Loratadine.Illicit, Withdrawn
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Loratadine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Loratadine.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Loratadine.Approved
CholecalciferolThe metabolism of Loratadine can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Loratadine.Approved
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Loratadine.Approved
CinacalcetThe metabolism of Loratadine can be decreased when combined with Cinacalcet.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Loratadine.Approved, Vet Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Loratadine.Approved, Investigational
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Loratadine.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Loratadine.Approved
ClarithromycinThe metabolism of Loratadine can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Loratadine can be decreased when combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Loratadine is combined with Clidinium.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Loratadine.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Loratadine.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Loratadine.Approved, Investigational
ClomipramineThe metabolism of Loratadine can be decreased when combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Loratadine is combined with Clonazepam.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Loratadine.Approved
ClopidogrelThe metabolism of Loratadine can be decreased when combined with Clopidogrel.Approved, Nutraceutical
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Loratadine.Approved, Illicit
ClotrimazoleThe metabolism of Loratadine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Loratadine.Approved
CobicistatThe serum concentration of Loratadine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Loratadine.Approved
CocaineThe metabolism of Loratadine can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Loratadine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Loratadine.Approved
ConivaptanThe serum concentration of Loratadine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Loratadine.Approved
CrizotinibThe metabolism of Loratadine can be decreased when combined with Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Loratadine is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Loratadine.Approved
CyclosporineThe metabolism of Loratadine can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Loratadine.Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Loratadine.Approved
DabrafenibThe serum concentration of Loratadine can be decreased when it is combined with Dabrafenib.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Loratadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Loratadine is combined with Dantrolene.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Loratadine.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Loratadine.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Loratadine is combined with Dapoxetine.Investigational
DarifenacinThe metabolism of Loratadine can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Loratadine can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Loratadine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Loratadine.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Loratadine.Approved
DeferasiroxThe serum concentration of Loratadine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Loratadine can be decreased when combined with Delavirdine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Loratadine.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Loratadine.Approved
DesipramineThe metabolism of Loratadine can be decreased when combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Loratadine is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Loratadine.Vet Approved
DexamethasoneThe serum concentration of Loratadine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Loratadine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Loratadine.Approved, Vet Approved
DextroamphetamineDextroamphetamine may decrease the sedative activities of Loratadine.Approved, Illicit
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Loratadine.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Loratadine.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Loratadine.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Loratadine.Approved, Illicit, Vet Approved
DiethylpropionDiethylpropion may decrease the sedative activities of Loratadine.Approved, Illicit
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Loratadine.Approved
DifenoxinThe risk or severity of adverse effects can be increased when Loratadine is combined with Difenoxin.Approved, Illicit
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Loratadine.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Loratadine.Approved
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Loratadine.Approved, Illicit
DihydroergotamineThe metabolism of Loratadine can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Loratadine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Loratadine.Experimental, Illicit
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Loratadine.Illicit
DiltiazemThe metabolism of Loratadine can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Loratadine is combined with Dimenhydrinate.Approved
DiphenhydramineThe metabolism of Loratadine can be decreased when combined with Diphenhydramine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Loratadine.Approved, Illicit
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Loratadine.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Loratadine.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Loratadine.Approved, Investigational, Vet Approved
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Loratadine.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Loratadine is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Loratadine.Approved, Investigational
DoxycyclineThe metabolism of Loratadine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Loratadine.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved, Illicit
DronedaroneThe metabolism of Loratadine can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Loratadine.Experimental, Illicit
DuloxetineThe metabolism of Loratadine can be decreased when combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Loratadine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Loratadine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Loratadine.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Loratadine is combined with Ecopipam.Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Loratadine.Approved
EfavirenzThe serum concentration of Loratadine can be decreased when it is combined with Efavirenz.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Loratadine.Approved, Investigational
EliglustatThe metabolism of Loratadine can be decreased when combined with Eliglustat.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Loratadine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Loratadine is combined with Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of Loratadine can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Loratadine.Approved, Investigational
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Loratadine.Approved, Investigational
ErythromycinThe metabolism of Loratadine can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Loratadine is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Loratadine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Loratadine.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Loratadine.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Loratadine.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Loratadine.Approved
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Loratadine.Approved
EthanolLoratadine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Loratadine.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Loratadine.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Loratadine is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Loratadine is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Loratadine.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Loratadine.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Loratadine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Loratadine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Loratadine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Loratadine.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Loratadine.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Loratadine is combined with Etoperidone.Approved
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Loratadine.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Loratadine.Illicit, Vet Approved
EtravirineThe serum concentration of Loratadine can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Loratadine.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Loratadine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Loratadine is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Loratadine is combined with Felbamate.Approved
FelodipineThe metabolism of Loratadine can be decreased when combined with Felodipine.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Loratadine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Loratadine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Loratadine.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Loratadine.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Loratadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Loratadine is combined with Flibanserin.Approved
FloxuridineThe metabolism of Loratadine can be decreased when combined with Floxuridine.Approved
FluconazoleThe metabolism of Loratadine can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Loratadine.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Loratadine is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Loratadine.Approved, Illicit
FluorouracilThe metabolism of Loratadine can be decreased when combined with Fluorouracil.Approved
FluoxetineThe metabolism of Loratadine can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Loratadine.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Loratadine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Loratadine.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Loratadine.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Loratadine.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Loratadine is combined with Fluticasone Propionate.Approved
FluvastatinThe metabolism of Loratadine can be decreased when combined with Fluvastatin.Approved
FluvoxamineThe metabolism of Loratadine can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Loratadine can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Loratadine can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Loratadine can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Loratadine.Approved, Illicit
Fusidic AcidThe serum concentration of Loratadine can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Loratadine.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Loratadine is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Loratadine.Approved, Illicit
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Loratadine.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Loratadine.Approved
GemfibrozilThe metabolism of Loratadine can be decreased when combined with Gemfibrozil.Approved
GepironeThe risk or severity of adverse effects can be increased when Loratadine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Loratadine.Approved, Illicit
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Loratadine.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Loratadine.Withdrawn
GuanfacineThe risk or severity of adverse effects can be increased when Loratadine is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Loratadine.Approved, Illicit, Withdrawn
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Loratadine.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Loratadine.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Loratadine.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Loratadine.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Loratadine.Approved, Investigational
HydrocodoneLoratadine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Loratadine.Approved, Vet Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Loratadine.Approved, Illicit
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may decrease the sedative activities of Loratadine.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Loratadine.Approved
IdelalisibThe serum concentration of Loratadine can be increased when it is combined with Idelalisib.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Loratadine is combined with Iloperidone.Approved
ImatinibThe metabolism of Loratadine can be decreased when combined with Imatinib.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Loratadine.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Loratadine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Loratadine is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Loratadine can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Loratadine.Approved, Investigational
IrbesartanThe metabolism of Loratadine can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Loratadine.Approved, Investigational
IsavuconazoniumThe metabolism of Loratadine can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Loratadine.Approved, Vet Approved
IsoniazidThe metabolism of Loratadine can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of Loratadine can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Loratadine can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Loratadine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Loratadine.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Loratadine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Loratadine.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Loratadine.Approved
KetoconazoleThe metabolism of Loratadine can be decreased when combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Loratadine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Loratadine.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Loratadine.Approved, Investigational
LapatinibThe metabolism of Loratadine can be decreased when combined with Lapatinib.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Loratadine.Approved
LeflunomideThe metabolism of Loratadine can be decreased when combined with Leflunomide.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Loratadine.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Loratadine.Approved
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Loratadine.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Loratadine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Loratadine is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Loratadine is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Loratadine is combined with Levodopa.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Loratadine.Approved, Investigational
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Loratadine.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Loratadine.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Loratadine.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Loratadine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Loratadine.Approved
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Loratadine.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Loratadine.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Loratadine.Illicit
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Loratadine.Approved
LopinavirThe metabolism of Loratadine can be decreased when combined with Lopinavir.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Loratadine.Approved
LorcaserinThe metabolism of Loratadine can be decreased when combined with Lorcaserin.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Loratadine.Approved
LovastatinThe metabolism of Loratadine can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Loratadine.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Loratadine.Investigational
LuliconazoleThe serum concentration of Loratadine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Loratadine can be increased when it is combined with Lumacaftor.Approved
LumefantrineThe metabolism of Loratadine can be decreased when combined with Lumefantrine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Loratadine.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved, Vet Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Loratadine.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Loratadine is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Loratadine is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Loratadine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Loratadine.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Loratadine.Approved
MephedroneMephedrone may decrease the sedative activities of Loratadine.Investigational
MephentermineMephentermine may decrease the sedative activities of Loratadine.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Loratadine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Loratadine.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Loratadine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Loratadine is combined with Metaxalone.Approved
MethadoneThe metabolism of Loratadine can be decreased when combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Loratadine.Approved, Illicit
MethamphetamineMethamphetamine may decrease the sedative activities of Loratadine.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Loratadine.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Loratadine.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Loratadine.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Loratadine.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Loratadine.Approved
MethotrimeprazineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Loratadine.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Loratadine is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Loratadine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Loratadine.Approved, Vet Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Loratadine.Approved, Investigational
MetyrosineLoratadine may increase the sedative activities of Metyrosine.Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Loratadine.Approved, Illicit
MifepristoneThe serum concentration of Loratadine can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Loratadine is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Loratadine.Approved
MirtazapineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Loratadine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Loratadine.Approved, Investigational
MMDAMMDA may decrease the sedative activities of Loratadine.Experimental, Illicit
ModafinilThe serum concentration of Loratadine can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Loratadine.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Loratadine.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Loratadine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Loratadine.Approved
NafcillinThe serum concentration of Loratadine can be decreased when it is combined with Nafcillin.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Loratadine.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Loratadine.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Loratadine.Approved, Vet Approved
NefazodoneThe metabolism of Loratadine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Loratadine can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Loratadine can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Loratadine can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Loratadine can be decreased when combined with Nicardipine.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Loratadine.Approved
NilotinibThe metabolism of Loratadine can be decreased when combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Loratadine.Approved
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Loratadine.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Loratadine.Approved, Vet Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Loratadine.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Loratadine.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Loratadine is combined with Nortriptyline.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Loratadine.Approved, Investigational
OlaparibThe metabolism of Loratadine can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Olopatadine.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Loratadine.Approved
OmeprazoleThe metabolism of Loratadine can be decreased when combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Loratadine.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Loratadine.Approved, Illicit
OrphenadrineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Loratadine.Investigational
OsimertinibThe serum concentration of Loratadine can be increased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Loratadine.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Loratadine is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Loratadine.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Loratadine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Loratadine.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Loratadine.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Loratadine.Approved, Vet Approved
PalbociclibThe serum concentration of Loratadine can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Loratadine.Approved
PanobinostatThe serum concentration of Loratadine can be increased when it is combined with Panobinostat.Approved, Investigational
ParaldehydeLoratadine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe metabolism of Loratadine can be decreased when combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Loratadine.Approved
Peginterferon alfa-2bThe serum concentration of Loratadine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Loratadine.Approved, Vet Approved
PentobarbitalThe metabolism of Loratadine can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved
PerazineThe risk or severity of adverse effects can be increased when Loratadine is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Loratadine.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Loratadine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Loratadine.Approved
PhenobarbitalThe metabolism of Loratadine can be increased when combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Loratadine.Approved
PhenterminePhentermine may decrease the sedative activities of Loratadine.Approved, Illicit
PhenytoinThe metabolism of Loratadine can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Loratadine.Approved
PioglitazoneThe metabolism of Loratadine can be decreased when combined with Pioglitazone.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Loratadine.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Loratadine is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Loratadine is combined with Piritramide.Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Loratadine.Approved
PizotifenThe risk or severity of adverse effects can be increased when Loratadine is combined with Pizotifen.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Loratadine.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Loratadine.Approved
PosaconazoleThe metabolism of Loratadine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleLoratadine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Loratadine.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Loratadine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Loratadine.Approved, Illicit
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Loratadine.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Loratadine.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Loratadine.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Loratadine.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Loratadine is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Loratadine.Approved
PrimidoneThe metabolism of Loratadine can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Loratadine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Loratadine.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Loratadine.Approved, Vet Approved
PromazineThe metabolism of Loratadine can be decreased when combined with Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Loratadine is combined with Promethazine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Loratadine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Loratadine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Loratadine.Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Loratadine.Approved, Investigational
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Loratadine.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Loratadine.Approved
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Loratadine.Investigational
PseudoephedrinePseudoephedrine may decrease the sedative activities of Loratadine.Approved
PyrimethamineThe metabolism of Loratadine can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Loratadine.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Loratadine.Approved
QuinidineThe metabolism of Loratadine can be decreased when combined with Quinidine.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Loratadine.Approved
RabeprazoleThe metabolism of Loratadine can be decreased when combined with Rabeprazole.Approved, Investigational
RacloprideThe risk or severity of adverse effects can be increased when Loratadine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Loratadine is combined with Ramelteon.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Loratadine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Loratadine.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Loratadine.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Loratadine.Approved, Withdrawn
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Loratadine.Approved
RifabutinThe metabolism of Loratadine can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Loratadine can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Loratadine can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Loratadine.Approved, Investigational
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Loratadine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Loratadine is combined with Ritanserin.Investigational
RitobegronRitobegron may decrease the sedative activities of Loratadine.Investigational
RitonavirThe metabolism of Loratadine can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Loratadine.Approved
RolapitantThe metabolism of Loratadine can be decreased when combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Loratadine.Approved, Investigational
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Loratadine.Vet Approved
RopiniroleLoratadine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Loratadine.Approved
RosiglitazoneThe metabolism of Loratadine can be decreased when combined with Rosiglitazone.Approved, Investigational
RotigotineLoratadine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Loratadine.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Loratadine.Experimental
Sage 547The risk or severity of adverse effects can be increased when Loratadine is combined with Sage 547.Investigational
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Loratadine.Approved, Vet Approved
SaquinavirThe metabolism of Loratadine can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Loratadine.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Loratadine is combined with Scopolamine.Approved
SecobarbitalThe metabolism of Loratadine can be increased when combined with Secobarbital.Approved, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Loratadine.Approved
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Loratadine.Approved, Withdrawn
SertralineThe metabolism of Loratadine can be decreased when combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Loratadine.Approved, Vet Approved
SildenafilThe metabolism of Loratadine can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Loratadine.Approved
SiltuximabThe serum concentration of Loratadine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Loratadine can be increased when it is combined with Simeprevir.Approved
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Loratadine.Approved, Investigational
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Loratadine.Approved
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Loratadine.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Loratadine.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Loratadine.Experimental
St. John's WortThe serum concentration of Loratadine can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Loratadine can be increased when it is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Loratadine.Approved, Investigational
SulfadiazineThe metabolism of Loratadine can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Loratadine can be decreased when combined with Sulfamethoxazole.Approved
SulfisoxazoleThe metabolism of Loratadine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Loratadine.Approved
SuvorexantLoratadine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Loratadine.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Loratadine.Approved
TandospironeThe risk or severity of adverse effects can be increased when Loratadine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Loratadine is combined with Tasimelteon.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Loratadine.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Loratadine.Approved
TelaprevirThe metabolism of Loratadine can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Loratadine can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Loratadine.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Loratadine.Approved
TerbinafineThe metabolism of Loratadine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TeriflunomideThe metabolism of Loratadine can be decreased when combined with Teriflunomide.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Loratadine is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Loratadine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Loratadine.Investigational
ThalidomideLoratadine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Loratadine.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Loratadine.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Loratadine.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Loratadine.Approved
TiagabineThe risk or severity of adverse effects can be increased when Loratadine is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Loratadine is combined with Tiapride.Investigational
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Loratadine.Approved
TiclopidineThe metabolism of Loratadine can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Loratadine.Vet Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Loratadine.Approved
TipranavirThe metabolism of Loratadine can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Loratadine is combined with Tizanidine.Approved
TocilizumabThe serum concentration of Loratadine can be decreased when it is combined with Tocilizumab.Approved
TolbutamideThe metabolism of Loratadine can be decreased when combined with Tolbutamide.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Loratadine.Approved, Withdrawn
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Loratadine.Approved
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Loratadine.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Loratadine.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Loratadine.Approved, Investigational
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Loratadine.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Loratadine.Experimental
TranylcypromineThe metabolism of Loratadine can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Loratadine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Loratadine.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Loratadine.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Loratadine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Loratadine.Approved, Vet Approved
TrimethoprimThe metabolism of Loratadine can be decreased when combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Loratadine is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Loratadine.Approved
Uc1010The risk or severity of adverse effects can be increased when Loratadine is combined with Uc1010.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Loratadine.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Loratadine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Loratadine.Approved, Investigational
ValsartanThe metabolism of Loratadine can be decreased when combined with Valsartan.Approved, Investigational
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Loratadine.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Loratadine.Approved
VenlafaxineThe metabolism of Loratadine can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Loratadine can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Loratadine is combined with Vigabatrin.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Loratadine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Loratadine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Loratadine.Approved
VoriconazoleThe metabolism of Loratadine can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Loratadine.Approved
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Loratadine.Vet Approved
ZafirlukastThe metabolism of Loratadine can be decreased when combined with Zafirlukast.Approved, Investigational
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Loratadine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Loratadine is combined with Ziconotide.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Loratadine.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Loratadine is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Loratadine can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Loratadine.Vet Approved
ZolpidemLoratadine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Loratadine is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Loratadine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Loratadine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Loratadine.Approved, Investigational
Food Interactions
  • Take on empty stomach: 1 hour before or 2 hours after meals.
References
Synthesis Reference

Alberto Stampa, Pelayo Camps, Gloria Rodriguez, Jordi Bosch, Maria del Carmen Onrubia, “Process for the preparation of loratadine.” U.S. Patent US6084100, issued July 04, 2000.

US6084100
General References
  1. See S: Desloratadine for allergic rhinitis. Am Fam Physician. 2003 Nov 15;68(10):2015-6. [PubMed:14655812 ]
  2. Menardo JL, Horak F, Danzig MR, Czarlewski W: A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4. [PubMed:9444440 ]
  3. Howarth PH: Histamine and asthma: an appraisal based on specific H1-receptor antagonism. Clin Exp Allergy. 1990 Aug;20 Suppl 2:31-41. [PubMed:1977506 ]
  4. Baroody FM, Naclerio RM: Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. [PubMed:11291777 ]
External Links
ATC CodesR06AX13
AHFS Codes
  • 04:08.00
  • 24:32.04
PDB EntriesNot Available
FDA labelDownload (232 KB)
MSDSDownload (51.7 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9754
Caco-2 permeable-0.5488
P-glycoprotein substrateSubstrate0.7337
P-glycoprotein inhibitor IInhibitor0.9505
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterNon-inhibitor0.5143
CYP450 2C9 substrateNon-substrate0.8197
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.677
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorInhibitor0.8949
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorNon-inhibitor0.831
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9359
Ames testNon AMES toxic0.6884
CarcinogenicityNon-carcinogens0.915
BiodegradationNot ready biodegradable0.9963
Rat acute toxicity2.8964 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7531
hERG inhibition (predictor II)Inhibitor0.8456
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Schering plough healthcare products inc
  • Taro pharmaceuticals usa inc
  • Apotex inc richmond hill
  • L perrigo co
  • Ranbaxy laboratories ltd
  • Silarx pharmaceuticals inc
  • Taro pharmaceutical industries ltd
  • Teva pharmaceuticals usa inc
  • Wockhardt eu operations (swiss) ag
  • Wyeth consumer healthcare
  • Impax laboratories inc
  • Watson laboratories inc florida
  • Apotex inc etobicoke site
  • Mylan pharmaceuticals inc
  • Perrigo co
  • Sandoz inc
Packagers
Dosage forms
FormRouteStrength
TabletOral10 mg/1
LiquidOral5 mg/5mL
TabletOral10 mg
Tablet, chewableOral5 mg/5mg
Tablet, chewableOral5 mg/1
Tablet, multilayer, extended releaseOral
Capsule, liquid filledOral10 mg/1
Tablet, orally disintegratingOral10 mg
Tablet, orally disintegratingOral5 mg
Tablet, orally disintegratingOral5 mg/1
SyrupOral1 mg
Tablet, extended releaseOral
Tablet, film coatedOral
Tablet, orally disintegratingOral10 mg/1
Tablet, film coated, extended releaseOral
CapsuleOral10 mg
Tablet, film coatedOral10 mg/1
SolutionOral5 mg/5mL
Prices
Unit descriptionCostUnit
Claritin 30 10 mg tablet Box29.99USD box
Lisinopril 100% powder21.6USD g
Zestril 40 mg tablet2.48USD tablet
Claritin-d 12 hour tablet sa2.46USD tablet
Prinivil 40 mg tablet2.4USD tablet
Zestril 30 mg tablet2.4USD tablet
Zestril 5 mg tablet1.54USD tablet
Lisinopril 30 mg tablet1.51USD tablet
Claritin 10 mg tablet1.48USD tablet
Claritin-d 24 hour tablet sa1.43USD tablet
Zestril 10 mg tablet1.43USD tablet
Claritin 10 mg reditabs1.4USD tablet
Lisinopril 40 mg tablet1.26USD tablet
Zestril 20 mg tablet1.25USD tablet
Prinivil 20 mg tablet1.23USD tablet
Prinivil 10 mg tablet1.15USD tablet
Loratadine-d 24hr tablet1.11USD tablet
Prinivil 5 mg tablet1.11USD tablet
Lisinopril 20 mg tablet1.07USD tablet
Child's claritin 5 mg tablet chew1.02USD tablet
Lisinopril 10 mg tablet0.99USD tablet
Lisinopril 5 mg tablet0.96USD tablet
CVS Pharmacy loratadine-d 24hr tablet0.89USD tablet
Zestril 2.5 mg tablet0.79USD tablet
Tavist nd 10 mg tablet0.74USD tablet
Wal-itin 10 mg tablet0.7USD tablet
Alavert d-12 allergy-sinus tablet0.68USD tablet
Alavert 10 mg tablet0.64USD tablet
Lisinopril 2.5 mg tablet0.64USD tablet
CVS Pharmacy loratadine 10 mg tablet0.52USD tablet
Loratadine 10 mg tablet0.47USD tablet
CVS Pharmacy allergy relief 10 mg tablet0.44USD tablet
Qc loratadine 10 mg tablet0.08USD tablet
Allergy relief 10 mg tablet0.07USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6132758 No1998-06-012018-06-01Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point134-136 °CPhysProp
water solubility0.000011 mg/mlNot Available
logP5.20SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0134 mg/mLALOGPS
logP4.8ALOGPS
logP4.55ChemAxon
logS-4.5ALOGPS
pKa (Strongest Basic)4.33ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area42.43 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity116.98 m3·mol-1ChemAxon
Polarizability41.67 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzocycloheptapyridines. These are aromatic compounds containing a benzene ring and a pyridine ring fused to a seven membered carbocycle.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzocycloheptapyridines
Sub ClassNot Available
Direct ParentBenzocycloheptapyridines
Alternative Parents
Substituents
  • Benzocycloheptapyridine
  • Piperidinecarboxylic acid
  • Chlorobenzene
  • Benzenoid
  • Pyridine
  • Piperidine
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Tertiary amine
  • Azacycle
  • Monocarboxylic acid or derivatives
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Cieslewicz G, Gondorowicz K, Grzelewska-Rzymowska I, Rozniecki J, Wojciechowska B: [Effect of loratadine--selective antagonist of histamine (H1) receptor--on allergen-induced bronchoconstriction in atopic asthmatics]. Pneumonol Alergol Pol. 1992;60(11-12):11-5. [PubMed:1303772 ]
  3. Cieslewicz G, Gondorowicz K, Grzelewska-Rzymowska I, Rozniecki J: [Effect of loratadine, selective antagonist of histamine H1 receptors, on histamine-induced bronchoconstriction]. Pneumonol Alergol Pol. 1995;63(5-6):281-5. [PubMed:7581058 ]
  4. Letari O, Miozzo A, Folco G, Belloni PA, Sala A, Rovati GE, Nicosia S: Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity. Eur J Pharmacol. 1994 Feb 15;266(3):219-27. [PubMed:8174605 ]
  5. Cavero I, Mestre M, Guillon JM, Heuillet E, Roach AG: Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans? Drug Saf. 1999;21 Suppl 1:19-31; discussion 81-7. [PubMed:10597865 ]
  6. Tamura T, Masaki S, Ohmori K, Karasawa A: Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology. 2005 Dec;75(1):45-52. Epub 2005 Jun 7. [PubMed:15942272 ]
  7. Grzelewska-Rzymowska I, Gondorowicz K, Cieslewicz G, Rozniecki J, Wojciechowska B: [Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction]. Pneumonol Alergol Pol. 1992;60(11-12):16-21. [PubMed:1303773 ]
  8. Menardo JL, Horak F, Danzig MR, Czarlewski W: A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4. [PubMed:9444440 ]
  9. Howarth PH: Histamine and asthma: an appraisal based on specific H1-receptor antagonism. Clin Exp Allergy. 1990 Aug;20 Suppl 2:31-41. [PubMed:1977506 ]
  10. Baroody FM, Naclerio RM: Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. [PubMed:11291777 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Warzecha H, Ferme D, Peer M, Frank A, Unger M: Bioconversion of the antihistaminc drug loratadine by tobacco cell suspension cultures expressing human cytochrome P450 3A4. J Biosci Bioeng. 2010 Mar;109(3):288-90. doi: 10.1016/j.jbiosc.2009.09.001. Epub 2009 Sep 29. [PubMed:20159579 ]
  2. Li C, Lee MY, Choi JS: Effects of silybinin, CYP3A4 and P-glycoprotein inhibitor in vitro, on the bioavailability of loratadine in rats. Pharmazie. 2010 Jul;65(7):510-4. [PubMed:20662320 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Barecki ME, Casciano CN, Johnson WW, Clement RP: In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos. 2001 Sep;29(9):1173-5. [PubMed:11502723 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Barecki ME, Casciano CN, Johnson WW, Clement RP: In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos. 2001 Sep;29(9):1173-5. [PubMed:11502723 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein. Drug Metab Dispos. 2001 Aug;29(8):1080-3. [PubMed:11454724 ]
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Drug created on June 13, 2005 07:24 / Updated on December 07, 2016 02:37