Acne Vulgaris

Also known as: Acne vulgaris / Comedo / Acne NOS / Acnes / Acne

DrugDrug NameDrug Description
DB00210AdapaleneA topical retinoid agent used for the treatment of acne vulgaris.
DB00548Azelaic acidA saturated dicarboxylic acid used to treat mild to moderate acne vulgaris.
DB09096Benzoyl peroxideAn antibacterial and anti-inflammatory agent used for the symptomatic treatment of mild to moderate acne vulgaris and rosacea.
DB01190ClindamycinAn antibiotic used to treat serious infections caused by susceptible anaerobic bacteria, such as intra-abdominal or pelvic infections, osteomyelitis, diabetic foot ulcers, and dental infections.
DB00250DapsoneA sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis.
DB01395DrospirenoneA progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions.
DB00199ErythromycinA macrolide antibiotic used to treat and prevent a variety of bacterial infections.
DB00499FlutamideAn antiandrogen used for locally confined stage B2-C and D-2 metastatic prostate carcinoma.
DB00635PrednisoneA corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.
DB00634SulfacetamideA corticosteroid used to treat inflammatory ocular conditions and acne vulgaris.
DB00755TretinoinA vitamin A derivative used to treat acne vulgaris, certain types of promyelocytic leukemia, and fine wrinkles.
DB00620TriamcinoloneA glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.
DB12808TrifaroteneA topical retinoid indicated for the treatment of acne vulgaris.
DrugDrug NameTargetType
DB00210AdapaleneRetinoic acid receptor alphatarget
DB00210AdapaleneRetinoic acid receptor RXR-betatarget
DB00210AdapaleneRetinoic acid receptor gammatarget
DB00210AdapaleneRetinoic acid receptor betatarget
DB00210AdapaleneRetinoic acid receptor RXR-gammatarget
DB00210AdapaleneRetinoic acid receptor RXR-alphatarget
DB00210AdapaleneProstaglandin G/H synthase 2target
DB00548Azelaic acid3-oxo-5-alpha-steroid 4-dehydrogenase 2target
DB00548Azelaic acidDNA polymerase Itarget
DB00548Azelaic acidThioredoxin reductasetarget
DB00548Azelaic acidTyrosinasetarget
DB00548Azelaic acid3-oxo-5-beta-steroid 4-dehydrogenasetarget
DB01190Clindamycin50S ribosomal protein L10target
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190Clindamycin23S ribosomal RNAtarget
DB00250DapsoneInactive dihydropteroate synthase 2target
DB00250DapsoneDihydropteroate synthase 1target
DB00250DapsoneCytochrome P450 2C9enzyme
DB00250DapsoneCytochrome P450 2E1enzyme
DB00250DapsoneCytochrome P450 3A4enzyme
DB00250DapsoneDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00250DapsoneProstaglandin G/H synthase 1enzyme
DB00250DapsoneProstaglandin G/H synthase 2enzyme
DB00250DapsoneCytochrome P450 2C8enzyme
DB00250DapsoneCytochrome P450 2C19enzyme
DB00250DapsoneArylamine N-acetyltransferase 2enzyme
DB00250DapsoneCytochrome P450 3A5enzyme
DB00250DapsoneCytochrome P450 3A7enzyme
DB00250DapsoneMyeloperoxidaseenzyme
DB00250DapsoneCytochrome P450 2C18enzyme
DB01395DrospirenoneProgesterone receptortarget
DB01395DrospirenoneMineralocorticoid receptortarget
DB01395DrospirenoneAndrogen receptortarget
DB01395DrospirenoneProstaglandin G/H synthase 2enzyme
DB01395DrospirenoneSerum paraoxonase/arylesterase 1enzyme
DB01395DrospirenoneGlucocorticoid receptortarget
DB01395DrospirenoneCytochrome P450 3A4enzyme
DB00199Erythromycin23S ribosomal RNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinP-glycoprotein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB00199ErythromycinCanalicular multispecific organic anion transporter 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DB00499FlutamideAndrogen receptortarget
DB00499FlutamideCytochrome P450 1A2enzyme
DB00499FlutamideCytochrome P450 3A4enzyme
DB00499FlutamideCytochrome P450 1A1enzyme
DB00499FlutamideCytochrome P450 1B1enzyme
DB00499FlutamideCytochrome P450 2C19enzyme
DB00499FlutamideCytochrome P450 3A5enzyme
DB00499FlutamideAryl hydrocarbon receptortarget
DB00499FlutamideNuclear receptor subfamily 1 group I member 2target
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneP-glycoprotein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1target
DB00635PrednisoneCytochrome P450 3A5enzyme
DB00634SulfacetamideDihydropteroate synthasetarget
DB00634SulfacetamideDihydropteroate synthase type-1target
DB00634SulfacetamideFolic acid synthesis protein FOL1target
DB00755TretinoinRetinoic acid receptor gammatarget
DB00755TretinoinRetinoic acid receptor RXR-betatarget
DB00755TretinoinRetinal dehydrogenase 1target
DB00755TretinoinRetinoic acid-induced protein 3target
DB00755TretinoinRetinoic acid receptor RXR-gammatarget
DB00755TretinoinNuclear receptor subfamily 0 group B member 1target
DB00755TretinoinRetinal dehydrogenase 2target
DB00755TretinoinRetinoic acid receptor responder protein 1target
DB00755TretinoinCytochrome P450 2C8enzyme
DB00755TretinoinCellular retinoic acid-binding protein 1transporter
DB00755TretinoinCellular retinoic acid-binding protein 2transporter
DB00755TretinoinCytochrome P450 2B6enzyme
DB00755TretinoinCytochrome P450 3A4enzyme
DB00755TretinoinCytochrome P450 3A5enzyme
DB00755TretinoinCytochrome P450 2A6enzyme
DB00755TretinoinCytochrome P450 3A7enzyme
DB00755TretinoinCytochrome P450 2C18enzyme
DB00755TretinoinCytochrome P450 2C9enzyme
DB00755TretinoinCytochrome P450 4A11enzyme
DB00755TretinoinCytochrome P450 1A1enzyme
DB00755TretinoinRetinoic acid receptor alphatarget
DB00755TretinoinRetinoic acid receptor betatarget
DB00755TretinoinLipocalin-1target
DB00755TretinoinOdorant-binding protein 2atarget
DB00755TretinoinRetinol-binding protein 4target
DB00755TretinoinSerum albumincarrier
DB00755Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
DB00755TretinoinRetinoic acid receptor RXR-alphatarget
DB00755TretinoinCytochrome P450 26A1target
DB00755TretinoinCytochrome P450 26B1target
DB00755TretinoinCytochrome P450 26C1target
DB00755TretinoinHematopoietic prostaglandin D synthasetarget
DB00620TriamcinoloneCorticosteroid-binding globulincarrier
DB00620TriamcinoloneGlucocorticoid receptortarget
DB00620TriamcinoloneCytochrome P450 3A4enzyme
DB00620TriamcinoloneProstaglandin G/H synthase 2enzyme
DB00620TriamcinoloneCholinesteraseenzyme
DB00620TriamcinoloneCytochrome P450 3A5enzyme
DB00620TriamcinoloneCytochrome P450 3A7enzyme
DB00620TriamcinoloneSerum albumincarrier
DB12808TrifaroteneCytochrome P450 2C9enzyme
DB12808TrifaroteneCytochrome P450 3A4enzyme
DB12808TrifaroteneCytochrome P450 2C8enzyme
DB12808TrifaroteneCytochrome P450 2B6enzyme
DB12808TrifaroteneRetinoic acid receptor gammatarget
DB12808TrifaroteneRetinoic acid receptor alphatarget
DB12808TrifaroteneRetinoic acid receptor betatarget
DrugDrug NamePhaseStatusCount
DB00207Azithromycin0Not Yet Recruiting1
DB00755Tretinoin0Completed2
DB00162Vitamin A0Not Yet Recruiting1
DB00210Adapalene1Completed4
DB00210Adapalene1Withdrawn1
DB00855Aminolevulinic acid1Completed1
DB09096Benzoyl peroxide1Completed8
DB01373Calcium1Completed1
DB01190Clindamycin1Completed7
DB00250Dapsone1Completed3
DB00250Dapsone1Withdrawn2
DB00158Folic acid1Completed1
DB10344Ginger1Completed1
DB00982Isotretinoin1Completed1
DB00935Oxymetazoline1Completed1
DB00165Pyridoxine1Completed1
DB14546Sulfate ion1Completed1
DB00799Tazarotene1Completed7
DB00373Timolol1Recruiting1
DB00755Tretinoin1Completed2
DB00755Tretinoin1Recruiting1
DB00126Ascorbic acid1 / 2Completed1
DB01190Clindamycin1 / 2Completed1
DB00254Doxycycline1 / 2Active Not Recruiting1
DB00254Doxycycline1 / 2Unknown Status1
DB11674Equol1 / 2Unknown Status1
DB00435Nitric Oxide1 / 2Completed1
DB12642Olumacostat glasaretil1 / 2Completed1
DB00936Salicylic acid1 / 2Completed1
DB00936Salicylic acid1 / 2Not Yet Recruiting1
DB15385Acebilustat2Completed1
DB00210Adapalene2Recruiting1
DB00855Aminolevulinic acid2Completed1
DB09096Benzoyl peroxide2Completed2
DB14947Bermekimab2Completed1
DB00083Botulinum toxin type A2Completed1
DB00083Botulinum toxin type A2Terminated1
DB12499Clascoterone2Completed3
DB01190Clindamycin2Completed1
DB06133Dimethylcurcumin2Completed1
DB00254Doxycycline2Completed2
DB00898Ethanol2Completed1
DB12119Gevokizumab2Completed1
DB11091Hydrogen peroxide2Completed1
DB15109Ingenol disoxate2Completed1
DB14181Lanolin alcohols2Recruiting1
DB00583Levocarnitine2Recruiting1
DB00992Methyl aminolevulinate2Completed2
DB01017Minocycline2Completed3
DB01017Minocycline2Recruiting1
DB12642Olumacostat glasaretil2Completed1
DB06574Omiganan2Completed2
DB06610Omiganan2Completed3
DB12096PF-051751572Withdrawn1
DB00936Salicylic acid2Recruiting1
DB12035Sarecycline2Completed1
DB00799Tazarotene2Completed5
DB00799Tazarotene2Not Yet Recruiting1
DB00755Tretinoin2Completed1
DB12808Trifarotene2Completed1
DB00744Zileuton2Unknown Status1
DB02300Calcipotriol2 / 3Completed1
DB11094Vitamin D2 / 3Completed1
DB00210Adapalene3Completed13
DB00210Adapalene3Recruiting1
DB00210Adapalene3Withdrawn1
DB00548Azelaic acid3Completed1
DB00207Azithromycin3Terminated1
DB09096Benzoyl peroxide3Completed18
DB09096Benzoyl peroxide3Unknown Status2
DB09096Benzoyl peroxide3Withdrawn1
DB12499Clascoterone3Completed3
DB01190Clindamycin3Completed12
DB01190Clindamycin3Recruiting2
DB00250Dapsone3Completed4
DB00250Dapsone3Recruiting1
DB00254Doxycycline3Recruiting1
DB01395Drospirenone3Completed4
DB00977Ethinylestradiol3Completed1
DB00756Hexachlorophene3Unknown Status1
DB00256Lymecycline3Completed1
DB01017Minocycline3Completed3
DB01017Minocycline3Terminated1
DB12642Olumacostat glasaretil3Completed3
DB12035Sarecycline3Completed3
DB12035Sarecycline3Withdrawn1
DB00421Spironolactone3Recruiting1
DB00799Tazarotene3Completed7
DB00755Tretinoin3Completed3
DB11152Trichloroacetate3Completed1
DB12808Trifarotene3Active Not Recruiting1
DB12808Trifarotene3Completed3
DB00210Adapalene4Completed27
DB00210Adapalene4Not Yet Recruiting1
DB00210Adapalene4Recruiting1
DB00210Adapalene4Terminated1
DB00548Azelaic acid4Completed3
DB09096Benzoyl peroxide4Completed29
DB09096Benzoyl peroxide4Recruiting1
DB09096Benzoyl peroxide4Unknown Status2
DB01190Clindamycin4Completed19
DB01190Clindamycin4Recruiting1
DB01190Clindamycin4Unknown Status2
DB04839Cyproterone acetate4Completed1
DB00250Dapsone4Completed9
DB00250Dapsone4Recruiting1
DB00304Desogestrel4Completed1
DB00254Doxycycline4Completed3
DB00199Erythromycin4Recruiting1
DB00783Estradiol4Completed1
DB00898Ethanol4Recruiting1
DB00977Ethinylestradiol4Completed1
DB00982Isotretinoin4Completed2
DB01017Minocycline4Terminated1
DB12447Nadifloxacin4Completed1
DB02701Nicotinamide4Completed1
DB00957Norgestimate4Completed1
DB00936Salicylic acid4Completed1
DB00799Tazarotene4Completed4
DB00799Tazarotene4Terminated1
DB00755Tretinoin4Completed11
DB00755Tretinoin4Terminated1
DB00755Tretinoin4Unknown Status2
DB11094Vitamin D4Not Yet Recruiting1
DB01593Zinc4Completed1
DB00210AdapaleneNot AvailableCompleted5
DB00855Aminolevulinic acidNot AvailableWithdrawn1
DB03793Benzoic acidNot AvailableCompleted1
DB09096Benzoyl peroxideNot AvailableCompleted12
DB01190ClindamycinNot AvailableCompleted3
DB04839Cyproterone acetateNot AvailableCompleted2
DB00254DoxycyclineNot AvailableCompleted1
DB00977EthinylestradiolNot AvailableCompleted2
DB00982IsotretinoinNot AvailableCompleted1