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Also known as: Acne vulgaris / Comedo / Acne NOS / Acnes / Acne
DrugDrug NameDrug Description
DB00548Azelaic AcidAzelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
DB09096Benzoyl peroxideBenzoyl peroxide (BPO) is an organic compound in the peroxide family. It consists of two benzoyl groups bridged by a peroxide link. It is one of the most important organic peroxides in terms of applications and the scale of its production. Benzoyl peroxide is used as an acne treatment (in combination or as a single agent), for bleaching flour, hair and teeth, for cross-linking polyester resins, and many other uses. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.
DB01190ClindamycinClindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB00250DapsoneA sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
DB01395DrospirenoneDrospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. It was shown in animal studies that drospirenone exhibits antiandrogenic activity judging from accessory sex gland growth in castrated, androgen-treated, juvenile rats.
DB00199ErythromycinErythromycin is a macrolide antibiotic produced by Saccharopolyspora erythraea (formerly Streptomyces erythraeus). It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB00499FlutamideAn antiandrogen with about the same potency as cyproterone in rodent and canine species.
DB00635PrednisoneA synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. [PubChem]
DB00634SulfacetamideAn anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. [PubChem]
DB00755TretinoinTretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
DB00620TriamcinoloneA glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
DB05294VandetanibVandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients.
DrugDrug NameTargetType
DB00548Azelaic Acid3-oxo-5-alpha-steroid 4-dehydrogenase 2target
DB00548Azelaic AcidDNA polymerase Itarget
DB00548Azelaic AcidThioredoxin reductasetarget
DB00548Azelaic AcidTyrosinasetarget
DB00548Azelaic Acid3-oxo-5-beta-steroid 4-dehydrogenasetarget
DB01190Clindamycin50S ribosomal protein L10target
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190Clindamycin23S rRNAtarget
DB00250DapsoneInactive dihydropteroate synthase 2target
DB00250DapsoneDihydropteroate synthase 1target
DB00250DapsoneCytochrome P450 2C9enzyme
DB00250DapsoneCytochrome P450 2E1enzyme
DB00250DapsoneCytochrome P450 3A4enzyme
DB00250DapsoneDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00250DapsoneProstaglandin G/H synthase 1enzyme
DB00250DapsoneProstaglandin G/H synthase 2enzyme
DB00250DapsoneCytochrome P450 2C8enzyme
DB00250DapsoneCytochrome P450 2C19enzyme
DB00250DapsoneArylamine N-acetyltransferase 2enzyme
DB00250DapsoneCytochrome P450 3A5enzyme
DB00250DapsoneCytochrome P450 3A7enzyme
DB00250DapsoneMyeloperoxidaseenzyme
DB00250DapsoneCytochrome P450 2C18enzyme
DB01395DrospirenoneProgesterone receptortarget
DB01395DrospirenoneMineralocorticoid receptortarget
DB01395DrospirenoneAndrogen receptortarget
DB01395DrospirenoneProstaglandin G/H synthase 2enzyme
DB01395DrospirenoneCholinesteraseenzyme
DB00199Erythromycin23S rRNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinMultidrug resistance protein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DB00199ErythromycinCytochrome P450 1A2enzyme
DB00199ErythromycinCytochrome P450 2B6enzyme
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinSerum albumintarget
DB00499FlutamideAndrogen receptortarget
DB00499FlutamideCytochrome P450 1A2enzyme
DB00499FlutamideCytochrome P450 3A4enzyme
DB00499FlutamideCytochrome P450 1A1enzyme
DB00499FlutamideCytochrome P450 1B1enzyme
DB00499FlutamideCytochrome P450 2C19enzyme
DB00499FlutamideCytochrome P450 3A5enzyme
DB00499FlutamideAryl hydrocarbon receptortarget
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneMultidrug resistance protein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1target
DB00634SulfacetamideDihydropteroate synthasetarget
DB00634SulfacetamideDihydropteroate synthase type-1target
DB00634SulfacetamideFolic acid synthesis protein FOL1target
DB00755TretinoinCytochrome P450 3A7enzyme
DB00755TretinoinCytochrome P450 2B6enzyme
DB00755TretinoinCytochrome P450 2C8enzyme
DB00755TretinoinCytochrome P450 2C9enzyme
DB00755TretinoinCytochrome P450 3A4enzyme
DB00755TretinoinCytochrome P450 3A5enzyme
DB00755TretinoinCytochrome P450 2A6enzyme
DB00755TretinoinCytochrome P450 2C18enzyme
DB00755TretinoinCytochrome P450 1A1enzyme
DB00755TretinoinCytochrome P450 4A11enzyme
DB00755TretinoinRetinoic acid receptor RXR-betatarget
DB00755TretinoinRetinoic acid receptor RXR-gammatarget
DB00755TretinoinRetinoic acid receptor gammatarget
DB00755TretinoinRetinal dehydrogenase 1target
DB00755TretinoinRetinoic acid-induced protein 3target
DB00755TretinoinNuclear receptor subfamily 0 group B member 1target
DB00755TretinoinRetinal dehydrogenase 2target
DB00755TretinoinRetinoic acid receptor responder protein 1target
DB00755TretinoinCellular retinoic acid-binding protein 1transporter
DB00755TretinoinCellular retinoic acid-binding protein 2transporter
DB00620TriamcinoloneCorticosteroid-binding globulincarrier
DB00620TriamcinoloneGlucocorticoid receptortarget
DB00620TriamcinoloneCytochrome P450 3A4enzyme
DB00620TriamcinoloneProstaglandin G/H synthase 2enzyme
DB00620TriamcinoloneCholinesteraseenzyme
DB05294VandetanibVascular endothelial growth factor Atarget
DB05294VandetanibEpidermal growth factor receptortarget
DB05294VandetanibMultidrug resistance-associated protein 1transporter
DB05294VandetanibATP-binding cassette sub-family G member 2transporter
DB05294VandetanibDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB05294VandetanibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB05294VandetanibProtein-tyrosine kinase 6target
DB05294VandetanibAngiopoietin-1 receptortarget
DB05294VandetanibAlpha-1-acid glycoprotein 1carrier
DB05294VandetanibSerum albumincarrier
DB05294VandetanibCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB00210Adapalene1Completed3
DB00210Adapalene1Withdrawn1
DB00855Aminolevulinic acid1Active Not Recruiting1
DB09096Benzoyl peroxide1Completed2
DB01190Clindamycin1Completed3
DB00250Dapsone1Completed1
DB00250Dapsone1Withdrawn2
DB00218Moxifloxacin1Active Not Recruiting1
DB00799Tazarotene1Completed3
DB01190Clindamycin1 / 2Completed1
DB00254Doxycycline1 / 2Not Yet Recruiting1
DB00254Doxycycline1 / 2Recruiting1
DB00936Salicylic acid1 / 2Completed1
DB00855Aminolevulinic acid2Completed1
DB09096Benzoyl peroxide2Completed1
DB00083Botulinum Toxin Type A2Terminated1
DB00160L-Alanine2Completed1
DB00799Tazarotene2Not Yet Recruiting1
DB00744Zileuton2Active Not Recruiting1
DB02300Calcipotriol2 / 3Active Not Recruiting1
DB00210Adapalene3Completed1
DB00210Adapalene3Withdrawn1
DB00548Azelaic Acid3Completed1
DB09096Benzoyl peroxide3Active Not Recruiting1
DB09096Benzoyl peroxide3Completed6
DB01190Clindamycin3Completed5
DB01395Drospirenone3Completed1
DB00977Ethinyl Estradiol3Completed1
DB00799Tazarotene3Completed1
DB00755Tretinoin3Completed2
DB00210Adapalene4Active Not Recruiting1
DB00210Adapalene4Completed5
DB00210Adapalene4Terminated1
DB00548Azelaic Acid4Completed3
DB09096Benzoyl peroxide4Completed10
DB01190Clindamycin4Completed7
DB00250Dapsone4Completed4
DB00254Doxycycline4Completed2
DB00982Isotretinoin4Completed1
DB00982Isotretinoin4Recruiting1
DB01017Minocycline4Terminated1
DB00799Tazarotene4Completed1
DB00755Tretinoin4Completed5
DB00755Tretinoin4Recruiting1
DB00755Tretinoin4Terminated1
DB00210AdapaleneNot AvailableCompleted1
DB09096Benzoyl peroxideNot AvailableCompleted3
DB01190ClindamycinNot AvailableCompleted1