Chemotherapy-Induced Nausea and Vomiting (CINV)

Also known as: Nausea Post Chemotherapy / Chemotherapy-Induced Nausea and Vomiting / Chemotherapy Induced Nausea and Vomiting / Nausea and Vomiting, Chemotherapy-Induced / Vomiting post chemotherapy / Emesis / Vomiting / Vomiting NOS / Vomited / Nausea / Queasy / Feeling queasy / Nauseated / Nauseous

DrugDrug NameDrug Description
DB00757DolasetronDolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is not shown to have activity at other known serotonin receptors, and has low affinity for dopamine receptors.
DB00450DroperidolA butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
DB00502HaloperidolA phenyl-piperidinyl-butyrophenone, traditional antipsychotic drug that is used primarily to treat schizophrenia and other psychoses. It is also used for the management of schizoaffective disorder, delusional disorders, ballism, and Tourette syndrome (a drug of choice) and occasionally as adjunctive therapy in mental retardation and the chorea associated with Huntington's disease. It is a potent antiemetic and is used in the treatment of intractable hiccups [L1994], [L1996]. The efficacy of haloperidol was first established in controlled trials in the 1960s [L2014]. Interestingly, in vivo pharmacogenetic studies have demonstrated that the metabolism of haloperidol may be modulated by genetically determined polymorphic _CYP2D6_ activity. However, these findings contradict the findings from studies in vitro with human liver microsomes and from drug interaction studies in vivo. Inter-ethnic and pharmacogenetic differences in haloperidol metabolism may possibly explain these observations [A32346].
DB00186LorazepamLorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic.[A957] It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.[L5095]
DB01233MetoclopramideA dopamine D2 antagonist that is used as an antiemetic.
DB00904OndansetronA competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. [PubChem] Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has demonstrated a long history of use and efficacy. Commonly formulated as oral tablets, orally disintegrating tablets (ODT), and injections, and available as generic products as well, ondansetron continues to see contemporary innovations in its formulation and use, including the development of orally soluble films that are both discreet in administration and less of a burden in comparison to having patients attempt to swallow pills during emesis [L5221].
DB00377PalonosetronPalonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy and is the only drug of its class approved for this use by the U.S. Food and Drug Administration. As of 2008, it is the most recent 5-HT3 antagonist to enter clinical use.
DrugDrug NameTargetType
DB00757Dolasetron5-hydroxytryptamine receptor 3Atarget
DB00757DolasetronCytochrome P450 3A4enzyme
DB00757DolasetronCytochrome P450 2D6enzyme
DB00757DolasetronCytochrome P450 2C9enzyme
DB00450DroperidolD(2) dopamine receptortarget
DB00450DroperidolAlpha-1A adrenergic receptortarget
DB00502HaloperidolD(2) dopamine receptortarget
DB00502HaloperidolGlutamate receptor ionotropic, NMDA 2Btarget
DB00502HaloperidolD(1A) dopamine receptortarget
DB00502HaloperidolCytochrome P450 1A2enzyme
DB00502HaloperidolCytochrome P450 2D6enzyme
DB00502Haloperidol5-hydroxytryptamine receptor 2Atarget
DB00502HaloperidolD(3) dopamine receptortarget
DB00502HaloperidolCytochrome P450 3A4enzyme
DB00502HaloperidolCytochrome P450 3A5enzyme
DB00502HaloperidolCytochrome P450 3A7enzyme
DB00502HaloperidolMultidrug resistance protein 1transporter
DB00502HaloperidolCarbonyl reductase [NADPH] 1enzyme
DB00502HaloperidolUDP-glucuronosyltransferase 1-9enzyme
DB00502HaloperidolCytochrome P450 1A1enzyme
DB00502HaloperidolCytochrome P450 2C19enzyme
DB00502HaloperidolCytochrome P450 2C9enzyme
DB00502HaloperidolMelanin-concentrating hormone receptor 1target
DB00502HaloperidolSynaptic vesicular amine transportertarget
DB00186LorazepamTranslocator proteintarget
DB00186LorazepamUDP-glucuronosyltransferase 2B15enzyme
DB00186LorazepamGABA-A receptor (anion channel)target
DB00186LorazepamCytochrome P450 3A4enzyme
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideD(2) dopamine receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233MetoclopramideCytochrome P450 11B1, mitochondrialenzyme
DB01233MetoclopramideCytochrome P450 11B2, mitochondrialenzyme
DB01233MetoclopramideSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01233MetoclopramideAcetylcholinesterasetarget
DB00904Ondansetron5-hydroxytryptamine receptor 3Atarget
DB00904OndansetronCytochrome P450 3A4enzyme
DB00904OndansetronCytochrome P450 1A2enzyme
DB00904OndansetronCytochrome P450 2D6enzyme
DB00904OndansetronCytochrome P450 3A5enzyme
DB00904OndansetronCytochrome P450 3A7enzyme
DB00904Ondansetron5-hydroxytryptamine receptor 4target
DB00904Ondansetron5-hydroxytryptamine receptor 1Atarget
DB00904Ondansetron5-hydroxytryptamine receptor 1Btarget
DB00904OndansetronMu-type opioid receptortarget
DB00904OndansetronCytochrome P450 2C9enzyme
DB00904OndansetronCytochrome P450 2E1enzyme
DB00377Palonosetron5-hydroxytryptamine receptor 3Atarget
DB00377PalonosetronCytochrome P450 2D6enzyme
DB00377PalonosetronCytochrome P450 3A4enzyme
DB00377PalonosetronCytochrome P450 1A2enzyme
DrugDrug NamePhaseStatusCount
DB00673Aprepitant1Completed4
DB00673Aprepitant1Terminated1
DB06634Casopitant1Completed7
DB06634Casopitant1Terminated1
DB01234Dexamethasone1Completed2
DB01234Dexamethasone1Terminated1
DB00390Digoxin1Completed1
DB01248Docetaxel1Completed1
DB00757Dolasetron1Completed1
DB06717Fosaprepitant1Completed2
DB06717Fosaprepitant1Terminated1
DB00889Granisetron1Completed2
DB00889Granisetron1Not Yet Recruiting2
DB01026Ketoconazole1Completed2
DB00683Midazolam1Completed1
DB00218Moxifloxacin1Completed1
DB00904Ondansetron1Completed5
DB00904Ondansetron1Terminated1
DB01045Rifampicin1Completed1
DB09291Rolapitant1Completed3
DB00412Rosiglitazone1Completed1
DB00795Sulfasalazine1Completed1
DB00682Warfarin1Completed1
DB00673Aprepitant2Completed2
DB00673Aprepitant2Not Yet Recruiting2
DB00673Aprepitant2Recruiting2
DB00673Aprepitant2Terminated1
DB00673Aprepitant2Unknown Status2
DB00564Carbamazepine2Unknown Status1
DB06634Casopitant2Completed1
DB01234Dexamethasone2Completed5
DB01234Dexamethasone2Not Yet Recruiting2
DB01234Dexamethasone2Recruiting2
DB00514Dextromethorphan2Completed1
DB06717Fosaprepitant2Completed2
DB06717Fosaprepitant2Not Yet Recruiting2
DB06717Fosaprepitant2Recruiting1
DB06717Fosaprepitant2Terminated1
DB06717Fosaprepitant2Unknown Status1
DB10344Ginger2Completed1
DB00889Granisetron2Completed2
DB09048Netupitant2Completed1
DB09048Netupitant2Recruiting1
DB00334Olanzapine2Completed1
DB00334Olanzapine2Recruiting1
DB00334Olanzapine2Unknown Status1
DB00904Ondansetron2Completed4
DB00904Ondansetron2Not Yet Recruiting1
DB00904Ondansetron2Recruiting2
DB00377Palonosetron2Completed5
DB00377Palonosetron2Not Yet Recruiting1
DB00377Palonosetron2Recruiting1
DB00377Palonosetron2Unknown Status1
DB09290Ramosetron2Completed1
DB01234Dexamethasone2 / 3Recruiting1
DB14019Fosnetupitant2 / 3Recruiting1
DB00377Palonosetron2 / 3Recruiting1
DB00673Aprepitant3Completed7
DB00673Aprepitant3Not Yet Recruiting2
DB00673Aprepitant3Recruiting2
DB00673Aprepitant3Terminated1
DB06634Casopitant3Completed3
DB06634Casopitant3Withdrawn1
DB11121Chloroxylenol3Completed1
DB01234Dexamethasone3Completed18
DB01234Dexamethasone3Not Yet Recruiting2
DB01234Dexamethasone3Recruiting2
DB01234Dexamethasone3Terminated1
DB01234Dexamethasone3Withdrawn1
DB00470Dronabinol3Completed2
DB06717Fosaprepitant3Completed4
DB06717Fosaprepitant3Terminated1
DB00889Granisetron3Completed8
DB09048Netupitant3Completed4
DB00334Olanzapine3Recruiting2
DB00904Ondansetron3Completed10
DB00904Ondansetron3Recruiting1
DB00904Ondansetron3Terminated1
DB00904Ondansetron3Withdrawn1
DB00377Palonosetron3Completed9
DB00377Palonosetron3Not Yet Recruiting1
DB00377Palonosetron3Recruiting1
DB09291Rolapitant3Completed3
DB11699Tropisetron3Not Yet Recruiting1
DB00334Olanzapine4Not Yet Recruiting1
DB00377Palonosetron4Completed1
DB00673AprepitantNot AvailableActive Not Recruiting1
DB00673AprepitantNot AvailableCompleted1
DB09110Coenzyme MNot AvailableCompleted1
DB01234DexamethasoneNot AvailableCompleted1
DB01234DexamethasoneNot AvailableNot Yet Recruiting1
DB01234DexamethasoneNot AvailableRecruiting1
DB00997DoxorubicinNot AvailableCompleted1
DB06717FosaprepitantNot AvailableActive Not Recruiting1
DB06717FosaprepitantNot AvailableCompleted2
DB14019FosnetupitantNot AvailableRecruiting1
DB01181IfosfamideNot AvailableCompleted1
DB00334OlanzapineNot AvailableEnrolling by Invitation1
DB00377PalonosetronNot AvailableEnrolling by Invitation1
DB00377PalonosetronNot AvailableRecruiting1
DB09290RamosetronNot AvailableNot Yet Recruiting1
DB01041ThalidomideNot AvailableRecruiting1
DB11699TropisetronNot AvailableNot Yet Recruiting1
DB00541VincristineNot AvailableCompleted1