Chemotherapy-Induced Nausea and Vomiting (CINV)

Also known as: Nausea Post Chemotherapy / Chemotherapy-Induced Nausea and Vomiting / Chemotherapy Induced Nausea and Vomiting / Nausea and Vomiting, Chemotherapy-Induced / Vomiting post chemotherapy / Emesis / Vomiting / Vomiting NOS / Vomited / Nausea / Queasy / Feeling queasy / Nauseated / Nauseous

DrugDrug NameDrug Description
DB00757DolasetronAn antinauseant and antiemetic used in chemotherapy and postoperatively.
DB00450DroperidolA butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting.
DB00502HaloperidolAn antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium.
DB00186LorazepamA long-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.
DB01233MetoclopramideAn antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.
DB00904OndansetronA serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
DB00377PalonosetronA serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting.
DrugDrug NameTargetType
DB00757Dolasetron5-hydroxytryptamine receptor 3Atarget
DB00757DolasetronCytochrome P450 3A4enzyme
DB00757DolasetronCytochrome P450 2D6enzyme
DB00757DolasetronCytochrome P450 2C9enzyme
DB00450DroperidolDopamine D2 receptortarget
DB00450DroperidolAlpha-1A adrenergic receptortarget
DB00502HaloperidolDopamine D2 receptortarget
DB00502HaloperidolGlutamate receptor ionotropic, NMDA 2Btarget
DB00502HaloperidolDopamine D1 receptortarget
DB00502HaloperidolCytochrome P450 1A2enzyme
DB00502HaloperidolCytochrome P450 2D6enzyme
DB00502Haloperidol5-hydroxytryptamine receptor 2Atarget
DB00502HaloperidolDopamine D3 receptortarget
DB00502HaloperidolCytochrome P450 3A4enzyme
DB00502HaloperidolCytochrome P450 3A5enzyme
DB00502HaloperidolCytochrome P450 3A7enzyme
DB00502HaloperidolP-glycoprotein 1transporter
DB00502HaloperidolCarbonyl reductase [NADPH] 1enzyme
DB00502HaloperidolUDP-glucuronosyltransferase 1-9enzyme
DB00502HaloperidolCytochrome P450 2C19enzyme
DB00502HaloperidolCytochrome P450 2C9enzyme
DB00502HaloperidolMelanin-concentrating hormone receptor 1target
DB00502HaloperidolSynaptic vesicular amine transportertarget
DB00502Haloperidol5-hydroxytryptamine receptor 2Ctarget
DB00502HaloperidolSigma non-opioid intracellular receptor 1target
DB00502HaloperidolHistamine H1 receptortarget
DB00502HaloperidolMuscarinic acetylcholine receptor M3target
DB00502HaloperidolAlpha-1A adrenergic receptortarget
DB00502HaloperidolAlpha-2A adrenergic receptortarget
DB00502HaloperidolAlpha-2B adrenergic receptortarget
DB00502HaloperidolAlpha-2C adrenergic receptortarget
DB00502Haloperidol5-hydroxytryptamine receptor 1Atarget
DB00502Haloperidol5-hydroxytryptamine receptor 6target
DB00502Haloperidol5-hydroxytryptamine receptor 7target
DB00502HaloperidolCytochrome P450 1A1enzyme
DB00186LorazepamTranslocator proteintarget
DB00186LorazepamUDP-glucuronosyltransferase 2B15enzyme
DB00186LorazepamGABA-A receptor (anion channel)target
DB00186LorazepamCytochrome P450 3A4enzyme
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideDopamine D2 receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01233MetoclopramideCytochrome P450 3A4enzyme
DB01233MetoclopramideCytochrome P450 1A2enzyme
DB01233MetoclopramideP-glycoprotein 1transporter
DB01233MetoclopramideAlpha-1-acid glycoprotein 1carrier
DB00904Ondansetron5-hydroxytryptamine receptor 3Atarget
DB00904OndansetronCytochrome P450 3A4enzyme
DB00904OndansetronCytochrome P450 1A2enzyme
DB00904OndansetronCytochrome P450 2D6enzyme
DB00904OndansetronCytochrome P450 3A5enzyme
DB00904OndansetronCytochrome P450 3A7enzyme
DB00904Ondansetron5-hydroxytryptamine receptor 4target
DB00904Ondansetron5-hydroxytryptamine receptor 1Atarget
DB00904Ondansetron5-hydroxytryptamine receptor 1Btarget
DB00904OndansetronMu-type opioid receptortarget
DB00904OndansetronCytochrome P450 2C9enzyme
DB00904OndansetronCytochrome P450 2E1enzyme
DB00377Palonosetron5-hydroxytryptamine receptor 3Atarget
DB00377PalonosetronCytochrome P450 2D6enzyme
DB00377PalonosetronCytochrome P450 3A4enzyme
DB00377PalonosetronCytochrome P450 1A2enzyme
DrugDrug NamePhaseStatusCount
DB00673Aprepitant1Completed4
DB00673Aprepitant1Terminated1
DB06634Casopitant1Completed7
DB06634Casopitant1Terminated1
DB00531Cyclophosphamide1Terminated1
DB01234Dexamethasone1Completed2
DB01234Dexamethasone1Terminated1
DB00390Digoxin1Completed1
DB01248Docetaxel1Completed1
DB00757Dolasetron1Completed1
DB06717Fosaprepitant1Completed3
DB06717Fosaprepitant1Terminated1
DB00889Granisetron1Completed2
DB00889Granisetron1Not Yet Recruiting2
DB01026Ketoconazole1Completed2
DB00683Midazolam1Completed1
DB00218Moxifloxacin1Completed1
DB00904Ondansetron1Completed5
DB00904Ondansetron1Terminated1
DB01045Rifampicin1Completed1
DB09291Rolapitant1Completed3
DB00412Rosiglitazone1Completed1
DB00795Sulfasalazine1Completed1
DB00682Warfarin1Completed1
DB00673Aprepitant2Completed2
DB00673Aprepitant2Not Yet Recruiting1
DB00673Aprepitant2Recruiting3
DB00673Aprepitant2Terminated1
DB00673Aprepitant2Unknown Status2
DB00564Carbamazepine2Unknown Status1
DB06634Casopitant2Completed1
DB01234Dexamethasone2Completed5
DB01234Dexamethasone2Not Yet Recruiting1
DB01234Dexamethasone2Recruiting3
DB06717Fosaprepitant2Completed2
DB06717Fosaprepitant2Recruiting1
DB06717Fosaprepitant2Terminated1
DB00889Granisetron2Completed2
DB00889Granisetron2Not Yet Recruiting1
DB09048Netupitant2Completed1
DB09048Netupitant2Recruiting1
DB00334Olanzapine2Completed1
DB00334Olanzapine2Recruiting1
DB00334Olanzapine2Unknown Status1
DB00904Ondansetron2Completed4
DB00904Ondansetron2Recruiting3
DB00377Palonosetron2Completed5
DB00377Palonosetron2Not Yet Recruiting1
DB00377Palonosetron2Recruiting1
DB00377Palonosetron2Unknown Status1
DB00213Pantoprazole2Not Yet Recruiting1
DB09290Ramosetron2Completed1
DB08839Serotonin2Completed1
DB01234Dexamethasone2 / 3Recruiting1
DB09048Netupitant2 / 3Recruiting1
DB00377Palonosetron2 / 3Recruiting1
DB00673Aprepitant3Completed8
DB00673Aprepitant3Not Yet Recruiting2
DB00673Aprepitant3Recruiting2
DB00673Aprepitant3Terminated1
DB06634Casopitant3Completed3
DB06634Casopitant3Withdrawn1
DB01234Dexamethasone3Completed19
DB01234Dexamethasone3Not Yet Recruiting2
DB01234Dexamethasone3Recruiting1
DB01234Dexamethasone3Terminated1
DB01234Dexamethasone3Withdrawn1
DB00470Dronabinol3Completed2
DB00470Dronabinol3Not Yet Recruiting1
DB06717Fosaprepitant3Completed4
DB06717Fosaprepitant3Terminated1
DB14019Fosnetupitant3Completed1
DB00889Granisetron3Completed8
DB09048Netupitant3Completed4
DB00334Olanzapine3Completed1
DB00334Olanzapine3Recruiting2
DB00904Ondansetron3Completed11
DB00904Ondansetron3Terminated1
DB00904Ondansetron3Withdrawn1
DB00377Palonosetron3Completed9
DB00377Palonosetron3Not Yet Recruiting1
DB00377Palonosetron3Recruiting1
DB09291Rolapitant3Completed3
DB11699Tropisetron3Not Yet Recruiting1
DB00673Aprepitant4Recruiting1
DB01234Dexamethasone4Recruiting2
DB06717Fosaprepitant4Recruiting1
DB00889Granisetron4Recruiting1
DB00334Olanzapine4Recruiting1
DB00904Ondansetron4Recruiting1
DB00377Palonosetron4Completed1
DB00673AprepitantNot AvailableActive Not Recruiting1
DB00673AprepitantNot AvailableCompleted1
DB09110Coenzyme MNot AvailableCompleted1
DB01234DexamethasoneNot AvailableCompleted1
DB01234DexamethasoneNot AvailableNot Yet Recruiting1
DB01234DexamethasoneNot AvailableRecruiting1
DB14649Dexamethasone acetateNot AvailableCompleted1
DB00997DoxorubicinNot AvailableCompleted1
DB06717FosaprepitantNot AvailableActive Not Recruiting1
DB06717FosaprepitantNot AvailableCompleted1
DB01181IfosfamideNot AvailableCompleted1
DB09048NetupitantNot AvailableActive Not Recruiting1
DB00334OlanzapineNot AvailableEnrolling by Invitation1
DB00377PalonosetronNot AvailableActive Not Recruiting1
DB00377PalonosetronNot AvailableEnrolling by Invitation1
DB00377PalonosetronNot AvailableRecruiting1
DB09290RamosetronNot AvailableNot Yet Recruiting1
DB01041ThalidomideNot AvailableRecruiting1
DB11699TropisetronNot AvailableNot Yet Recruiting1
DB00541VincristineNot AvailableCompleted1