Monopotassium phosphate

Identification

Name
Monopotassium phosphate
Accession Number
DB09413
Type
Small Molecule
Groups
Approved, Investigational, Vet approved
Description

Monopotassium phosphate, MKP, (also potassium dihydrogenphosphate, KDP, or monobasic potassium phosphate), KH2PO4, is a soluble salt of potassium and the dihydrogen phosphate ion. It is a source of phosphorus and potassium. It is also a buffering agent. When used in fertilizer mixtures with urea and ammonium phosphates, it minimizes escape of ammonia by keeping the pH at a relatively low level.

Structure
Thumb
Synonyms
  • Monobasic potassium phosphate
  • Monopotassium dihydrogen monophosphate
  • Monopotassium dihydrogen orthophosphate
  • Monopotassium dihydrogen phosphate
  • Monopotassium monophosphate
  • Monopotassium orthophosphate
  • Phosphoric acid, monopotassium salt
  • Potassium acid phosphate
  • Potassium biphosphate
  • Potassium dihydrogen orthophosphate
  • Potassium dihydrogen phosphate
  • Potassium phosphate
  • Potassium phosphate monobasic
  • Potassium phosphate monobasic (anhydrous)
  • Potassium phosphate, monobasic
  • Potassium phosphate,monobasic
External IDs
E-340(I) / INS NO.340(I) / INS-340(I)
Active Moieties
NameKindUNIICASInChI Key
Potassium cationionic295O53K15224203-36-9NPYPAHLBTDXSSS-UHFFFAOYSA-N
Phosphate ionionicNK08V8K8HR14265-44-2NBIIXXVUZAFLBC-UHFFFAOYSA-K
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Phosphate De Potassium Monobasic Inj 176mg/mlLiquid176 mgIntravenousSandoz Canada Incorporated1987-12-31Not applicableCanada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
ArtisialMonopotassium phosphate (32.6 mg) + Calcium Chloride (16.625 mg) + Dipotassium phosphate (80.3 mg) + Magnesium chloride (5.875 mg) + Potassium Chloride (62.45 mg) + Sodium Chloride (86.55 mg)LiquidBuccalJouveinal Inc.1986-12-311996-09-09Canada
Dextrose 5% and Electrolyte No75 InjMonopotassium phosphate (100 mg) + Dextrose, unspecified form (5 g) + Sodium lactate (220 mg) + Potassium Chloride (205 mg) + Sodium Chloride (120 mg)LiquidIntravenousBaxter Laboratories1990-12-312011-05-10Canada
Dextrose and Electrolyte No. 48Monopotassium phosphate (20 mg/100mL) + D-glucose monohydrate (5 g/100mL) + Sodium lactate (260 mg/100mL) + Magnesium chloride hexahydrate (31 mg/100mL) + Potassium Chloride (141 mg/100mL) + Sodium Chloride (12 mg/100mL)InjectionIntravenousBaxter Laboratories1979-02-02Not applicableUs
Dextrose and Electrolyte No. 75Monopotassium phosphate (100 mg/100mL) + D-glucose monohydrate (5 g/100mL) + Sodium lactate (220 mg/100mL) + Potassium Chloride (205 mg/100mL) + Sodium Chloride (120 mg/100mL)Injection, solutionIntravenousBaxter Laboratories2006-08-31Not applicableUs
Formula O-care Vitamin and Mineral SupplementMonopotassium phosphate (265.3 mg) + Biotin (33.3 mcg) + Calcium (333.3 mg) + Cholecalciferol (133.3 unit) + Copper (0.34 mg) + Folic Acid (0.033 mg) + Magnesium (167 mg) + Manganese (0.67 mg) + Pyridoxine hydrochloride (1.33 mg) + Riboflavin (1.1 mg) + Zinc (1.67 mg)TabletOralFor Mor International Inc.2000-03-252002-06-25Canada
Ionosol MB and DextroseMonopotassium phosphate (15 mg/100mL) + D-glucose monohydrate (5 g/100mL) + Sodium lactate (260 mg/100mL) + Magnesium chloride hexahydrate (30 mg/100mL) + Potassium Chloride (141 mg/100mL) + Sodium phosphate, monobasic, monohydrate (25 mg/100mL)Injection, solutionIntravenousHospira, Inc.2005-04-30Not applicableUs
Isolyte S pH 7.4Monopotassium phosphate (0.00082 g/100mL) + Sodium gluconate (0.5 g/100mL) + Magnesium chloride hexahydrate (0.03 g/100mL) + Potassium Chloride (0.037 g/100mL) + Sodium Chloride (0.53 g/100mL) + Sodium acetate trihydrate (0.37 g/100mL) + Sodium phosphate, dibasic, unspecified form (0.012 g/100mL)Injection, solutionIntravenousB. Braun Medical Inc.1989-09-29Not applicableUs
Isolyte S Ph 7.4 (multi-electrolyte Injection)Monopotassium phosphate (820 mcg) + Sodium gluconate (500 mg) + Magnesium chloride (30 mg) + Potassium Chloride (37 mg) + Sodium Chloride (530 mg) + Sodium acetate (370 mg) + Sodium phosphate, dibasic (12 mg)SolutionIntravenousB. Braun Medical Inc.1996-09-10Not applicableCanada
IsoplateMonopotassium phosphate (0.00082 g/100mL) + Sodium gluconate (0.5 g/100mL) + Magnesium chloride hexahydrate (0.03 g/100mL) + Potassium Chloride (0.037 g/100mL) + Sodium Chloride (0.53 g/100mL) + Sodium acetate trihydrate (0.37 g/100mL) + Sodium phosphate, dibasic, unspecified form (0.008 g/100mL)SolutionIntravenousTerumo BCT Ltd.2013-03-05Not applicableUs
IsoplateMonopotassium phosphate (0.00082 g/100mL) + Sodium gluconate (0.5 g/100mL) + Magnesium chloride hexahydrate (0.03 g/100mL) + Potassium Chloride (0.037 g/100mL) + Sodium Chloride (0.53 g/100mL) + Sodium acetate trihydrate (0.37 g/100mL) + Sodium phosphate, dibasic, unspecified form (0.012 g/100mL)SolutionIntravenousB. Braun Medical Inc.2013-03-052013-04-19Us
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralAvera McKennan Hospital2015-03-112018-06-05Us69189 010420180907 15195 1028m42
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralKaiser Foundations Hospitals2014-07-07Not applicableUs
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralCardinal Health2012-06-282018-05-17Us55154 767620180907 15195 nnrmgf
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralRising Pharmaceuticals, Inc.2012-06-28Not applicableUs
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralAmerincan Health Packaging2014-06-02Not applicableUs
Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium PhosphateMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)TabletOralCarilion Materials Management2012-06-28Not applicableUs64980 0104 01 nlmimage10 cc046643
K Phos NeutralMonopotassium phosphate (155 mg/1) + Sodium phosphate, dibasic (852 mg/1) + Sodium phosphate, monobasic, monohydrate (130 mg/1)Tablet, coatedOralBeach Productsd, Inc.1977-04-11Not applicableUs0486 112520180907 15195 1fdxkci
K Phos OriginalMonopotassium phosphate (500 mg/1)Tablet, solubleOralCarilion Materials Management1977-03-29Not applicableUs68151 219320180907 15195 nwccib
K Phos OriginalMonopotassium phosphate (500 mg/1)Tablet, solubleOralBeach Productsd, Inc.1977-03-29Not applicableUs00486 1111 01 nlmimage10 4549a2ed
K-Phos No. 2Monopotassium phosphate (305 mg/1) + Sodium phosphate, monobasic (700 mg/1)Tablet, coatedOralBeach Productsd, Inc.1978-05-09Not applicableUs
Categories
UNII
4J9FJ0HL51
CAS number
7778-77-0
Weight
Average: 136.0855
Monoisotopic: 135.932776925
Chemical Formula
H2KO4P
InChI Key
GNSKLFRGEWLPPA-UHFFFAOYSA-M
InChI
InChI=1S/K.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+1;/p-1
IUPAC Name
potassium dihydrogen phosphate
SMILES
[K+].OP(O)([O-])=O

Pharmacology

Indication

Used in buffers (determination of pH, pharmaceutical production, urinary acidifier, paper processing, baking powder, and food), nutrient solutions, yeast foods, special liquid fertilizers, sonar systems and other electronic applications; Used as a nutritional supplement in foods, a nonlinear optical material for laser use, and in wastewater treatment;

Associated Therapies
Pharmacodynamics

Potassium is the major cation of intracellular fluid and is essential for maintenance of acid-base balance, isotonicity, and electrodynamic characteristics of the cell. Potassium is an important activator in many enzymatic reactions and is essential to a number of physiologic processes including transmission of nerve impulses; contraction of cardiac, smooth, and skeletal muscles; gastric secretion; renal function; tissue synthesis; and carbohydrate metabolism. Phosphate is a major intracellular anion that participates in providing energy for metabolism of substrates and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions.

Mechanism of action

hosphorus has a number of important functions in the biochemistry of the body. The bulk of the body's phosphorus is located in the bones, where it plays a key role in osteoblastic and osteoclastic activities. Enzymatically catalyzed phosphate-transfer reactions are numerous and vital in the metabolism of carbohydrate, lipid and protein, and a proper concentration of the anion is of primary importance in assuring an orderly biochemical sequence. ln addition, phosphorus plays an important role in modifying steady-state tissue concentrations of calcium. Phosphate ions are important buffers of the intracellular fluid, and also play a primary role in the renal excretion of the hydrogen ion. Oral administration of inorganic phosphates increases serum phosphate levels. Phosphates lower urinary calcium levels in idiopathic hypercalciuria.

Absorption

Potassium salts are well absorbed from the GI tract. Ingested phosphates are absorbed from the gastrointestinal tract. However, the presence of large amounts of calcium or aluminum may lead to formation of insoluble phosphate and reduce the net absorption. Vitamin D stimulates phosphate absorption.

Volume of distribution

Potassium first enters the extracellular fluid and is then actively transported into the cells where its concentration is up to 40 times that outside the cell. Dextrose, insulin, and oxygen facilitate movement of potassium into cells.

Protein binding

In healthy adults, plasma potassium concentrations generally range from 3.5-5 mEq/L. Plasma concentrations up to 7.7 mEq/L may be normal in neonates.

Metabolism
Not Available
Route of elimination

Renal (90%) and fecal (10%) Phosphates Potassium is excreted mainly by the kidneys. Small amounts of potassium may be excreted via the skin and intestinal tract, but most of the potassium excreted into the intestine is later reabsorbed.

Half life

In healthy children with phosphate overdose, half-life was 4.8 to 10.6 hours, and was prolonged to 17 hours in a child with renal insufficiency.

Clearance

Phosphates are rapidly cleared by dialysis. Dialysis can also be used to treat other electrolyte abnormalities such as hypernatremia, hypocalcemia, and hypomagnesemia.

Toxicity

Rabbit : LD50 >4640mg/kg (skin) Rat : LdLo : 4640mg/kg (Oral)

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidThe risk or severity of hyperkalemia can be increased when Monopotassium phosphate is combined with 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid.
AcebutololMonopotassium phosphate may increase the hyperkalemic activities of Acebutolol.
AceclofenacMonopotassium phosphate may increase the hyperkalemic activities of Aceclofenac.
AcemetacinMonopotassium phosphate may increase the hyperkalemic activities of Acemetacin.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Monopotassium phosphate.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Monopotassium phosphate.
AclidiniumThe therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Aclidinium.
AgmatineThe therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Agmatine.
AlclofenacMonopotassium phosphate may increase the hyperkalemic activities of Alclofenac.
AlcuroniumThe therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Alcuronium.
Food Interactions
Not Available

References

General References
  1. Wikipedia [Link]
  2. Pubchem [Link]
  3. ChemIDplus [Link]
  4. DAILYMED [Link]
  5. Toxnet [Link]
External Links
PubChem Compound
516951
PubChem Substance
347827846
ChemSpider
22914
BindingDB
50004328
ChEBI
63036
ChEMBL
CHEMBL1200925
Wikipedia
Monopotassium_phosphate
AHFS Codes
  • 40:12.00 — Replacement Preparations

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingBasic ScienceHypoglycemia1
2Unknown StatusTreatmentHypophosphatemia / Osteopenia Of Prematurity1
3CompletedTreatmentHypercalciuria / Renal Stones1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidBuccal
LiquidIntravenous
InjectionIntravenous
Injection, solutionIntravenous
TabletOral
SolutionIntravenous
Tablet, coatedOral
Tablet, solubleOral500 mg/1
LiquidTopical
LiquidIntravenous176 mg
Injection, solution, concentrateIntravenous
PowderOral
IrrigantIrrigation
SolutionIrrigation
LiquidIrrigation
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area80.59 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity13.53 m3·mol-1ChemAxon
Polarizability5.53 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as alkali metal phosphates. These are inorganic compounds in which the largest oxoanion is phosphate, and in which the heaviest atom not in an oxoanion is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal oxoanionic compounds
Sub Class
Alkali metal phosphates
Direct Parent
Alkali metal phosphates
Alternative Parents
Inorganic salts / Inorganic oxides
Substituents
Alkali metal phosphate / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
potassium salt, inorganic phosphate (CHEBI:63036)

Enzymes

Kind
Protein
Organism
Bos taurus
Pharmacological action
Yes
Actions
Cofactor
General Function
Zinc ion binding
Specific Function
Not Available
Gene Name
ALPI
Uniprot ID
P19111
Uniprot Name
Intestinal-type alkaline phosphatase
Molecular Weight
57099.1 Da
References
  1. UniProt [Link]
  2. CHEMbl [Link]

Drug created on November 30, 2015 12:10 / Updated on December 10, 2018 13:39