Dipotassium phosphate

Identification

Name
Dipotassium phosphate
Accession Number
DB09414
Type
Small Molecule
Groups
Approved
Description

Dipotassium phosphate (K2HPO4) (also dipotassium hydrogen orthophosphate; potassium phosphate dibasic) is a highly water-soluble salt which is often used as a fertilizer, food additive and buffering agent. It is a common source of phosphorus and potassium.

Structure
Thumb
Synonyms
  • Di-potassium hydrogen phosphate
  • Dibasic potassium phosphate
  • Dipotassium acid phosphate
  • Dipotassium hydrogen monophosphate
  • Dipotassium hydrogen orthophosphate
  • Dipotassium hydrogen phosphate
  • Dipotassium monophosphate
  • Kali phosphoricum
  • Phosphoric acid, dipotassium salt
  • Phosphoric acid, potassium salt (1:2)
  • Potassium phosphate dibasic
  • Potassium phosphate, dibasic
  • Potassium phosphate,dibasic
  • Secondary potassium phosphate
External IDs
231-834-5 / E-340(II) / INS no.340(II) / INS-340(II)
Active Moieties
NameKindUNIICASInChI Key
Potassium cationionic295O53K15224203-36-9NPYPAHLBTDXSSS-UHFFFAOYSA-N
Phosphate ionionicNK08V8K8HR14265-44-2NBIIXXVUZAFLBC-UHFFFAOYSA-K
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
2.5% Travasol Amino Acid Injection With Electrolytes In 10% DextroseDipotassium phosphate (130.5 mg) + Dextrose, unspecified form (10 g) + Glycine (260 mg) + Histidine (120 mg) + L-Alanine (520 mg) + L-Arginine (290 mg) + L-Isoleucine (150 mg) + L-Leucine (182.5 mg) + L-Lysine (145 mg) + L-Phenylalanine (140 mg) + L-Proline (170 mg) + L-Threonine (105 mg) + L-Tryptophan (45 mg) + L-Tyrosine (10 mg) + L-Valine (145 mg) + Magnesium chloride (25.5 mg) + Methionine (100 mg) + Serine (125 mg) + Sodium Chloride (29.3 mg) + Sodium acetate (170 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada
2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose ClinimixDipotassium phosphate (130.5 mg) + Dextrose, unspecified form (10 g) + Glycine (520 mg) + Histidine (110 mg) + L-Alanine (520 mg) + L-Arginine (260 mg) + L-Isoleucine (120 mg) + L-Leucine hydrochloride (155 mg) + L-Lysine hydrochloride (145 mg) + Phenylalanine hydrochloride (155 mg) + L-Proline (105 mg) + L-Threonine (105 mg) + L-Tryptophan (45 mg) + L-Tyrosine (10 mg) + L-Valine (115 mg) + Magnesium chloride (25.5 mg) + Methionine (145 mg) + Sodium Chloride (29.3 mg) + Sodium acetate (170 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1993-12-312015-08-05Canada
2.5%travasol Amino Acid InJ.W.eleC.W.25%dexDipotassium phosphate (130.5 mg) + Dextrose, unspecified form (25 g) + Glycine (260 mg) + Histidine (120 mg) + L-Alanine (520 mg) + L-Arginine (290 mg) + L-Isoleucine (150 mg) + L-Leucine (182.5 mg) + L-Lysine (145 mg) + L-Phenylalanine (140 mg) + L-Proline (170 mg) + L-Threonine (105 mg) + L-Tryptophan (45 mg) + L-Tyrosine (10 mg) + L-Valine (145 mg) + Magnesium chloride (25.5 mg) + Methionine (100 mg) + Serine (125 mg) + Sodium Chloride (29.3 mg) + Sodium acetate (170 mg)LiquidIntravenousClintec Nutrition Company1996-07-301998-08-13Canada
2.75% Travas. Amino Acid InJ.W.elecw.25%dexDipotassium phosphate (261 mg) + Dextrose, unspecified form (25 g) + Glycine (283 mg) + Histidine (132 mg) + L-Alanine (570 mg) + L-Arginine (316 mg) + L-Isoleucine (165 mg) + L-Leucine (201 mg) + L-Lysine (159.5 mg) + L-Phenylalanine (154 mg) + L-Proline (187 mg) + L-Threonine (115.5 mg) + L-Tryptophan (49.5 mg) + L-Tyrosine (11 mg) + L-Valine (159.5 mg) + Magnesium chloride (51 mg) + Methionine (110 mg) + Serine (137.5 mg) + Sodium Chloride (112 mg) + Sodium acetate (215.5 mg)LiquidIntravenousClintec Nutrition Company1996-07-301998-08-13Canada
2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose QuickmixDipotassium phosphate (261 mg) + Dextrose, unspecified form (25 g) + Glycine (570 mg) + Histidine (120.5 mg) + L-Alanine (570 mg) + L-Arginine (285 mg) + L-Isoleucine (131.5 mg) + L-Leucine hydrochloride (170 mg) + L-Lysine hydrochloride (159 mg) + Phenylalanine hydrochloride (170 mg) + L-Proline (115 mg) + L-Threonine (115 mg) + L-Tryptophan (49.5 mg) + L-Tyrosine (11 mg) + L-Valine (126 mg) + Magnesium chloride (51 mg) + Methionine (159 mg) + Sodium Chloride (112 mg) + Sodium acetate (215.5 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-02-022007-08-02Canada
2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose QuickmixDipotassium phosphate (215.5 mg) + Dextrose, unspecified form (5 g) + Glycine (570 mg) + Histidine (120.5 mg) + L-Alanine (570 mg) + L-Arginine (285 mg) + L-Isoleucine (131.5 mg) + L-Leucine hydrochloride (170 mg) + L-Lysine hydrochloride (159 mg) + Phenylalanine hydrochloride (170 mg) + L-Proline (115 mg) + L-Threonine (115 mg) + L-Tryptophan (49.5 mg) + L-Tyrosine (11 mg) + L-Valine (126 mg) + Magnesium chloride (51 mg) + Methionine (159 mg) + Sodium Chloride (112 mg) + Sodium acetate (256 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1993-12-312007-08-02Canada
2.75%travasol Amino Acid InJ.W.eleC.W.5%dex.Dipotassium phosphate (261 mg) + Dextrose, unspecified form (5 g) + Glycine (283 mg) + Histidine (132 mg) + L-Alanine (570 mg) + L-Arginine (316 mg) + L-Isoleucine (165 mg) + L-Leucine (201 mg) + L-Lysine (159.5 mg) + L-Phenylalanine (154 mg) + L-Proline (187 mg) + L-Threonine (115.5 mg) + L-Tryptophan (49.5 mg) + L-Tyrosine (11 mg) + L-Valine (159.5 mg) + Magnesium chloride (51 mg) + Methionine (110 mg) + Serine (137.5 mg) + Sodium Chloride (112 mg) + Sodium acetate (215 mg)LiquidIntravenousClintec Nutrition Company1996-12-311999-08-10Canada
4.25% Travasol Amino Acid Injection With Electrolytes In 10% DextroseDipotassium phosphate (261 mg) + Dextrose, unspecified form (10 g) + Glycine (438 mg) + Histidine (204 mg) + L-Alanine (880 mg) + L-Arginine (489 mg) + L-Isoleucine (255 mg) + L-Leucine (310 mg) + L-Lysine hydrochloride (246.5 mg) + L-Phenylalanine (238 mg) + L-Proline (289 mg) + L-Threonine (178.5 mg) + L-Tryptophan (76.5 mg) + L-Tyrosine (17 mg) + L-Valine (246.5 mg) + Magnesium chloride (51 mg) + Methionine (170 mg) + Serine (212.5 mg) + Sodium Chloride (77 mg) + Sodium acetate (297 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada
4.25% Travasol Amino Acid Injection With Electrolytes In 20% DextroseDipotassium phosphate (261 mg) + Dextrose, unspecified form (20 g) + Glycine (438 mg) + Histidine (204 mg) + L-Alanine (880 mg) + L-Arginine (489 mg) + L-Isoleucine (255 mg) + L-Leucine (310 mg) + L-Lysine hydrochloride (246.5 mg) + L-Phenylalanine (238 mg) + L-Proline (289 mg) + L-Threonine (178.5 mg) + L-Tryptophan (76.5 mg) + L-Tyrosine (17 mg) + L-Valine (246.5 mg) + Magnesium chloride (51 mg) + Methionine (170 mg) + Serine (212.5 mg) + Sodium Chloride (77 mg) + Sodium acetate (297 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312007-08-02Canada
4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose QuickmixDipotassium phosphate (261 mg) + Dextrose, unspecified form (20 g) + Glycine (880 mg) + Histidine (186 mg) + L-Alanine (880 mg) + L-Arginine (440 mg) + L-Isoleucine (203 mg) + L-Leucine hydrochloride (263 mg) + L-Lysine hydrochloride (246 mg) + Phenylalanine hydrochloride (263 mg) + L-Proline (178 mg) + L-Threonine (178 mg) + L-Tryptophan (76 mg) + L-Tyrosine (17 mg) + L-Valine (195 mg) + Magnesium chloride (51 mg) + Methionine (246 mg) + Sodium Chloride (77 mg) + Sodium acetate (297 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1995-12-312007-08-02Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Potassium PhosphatesDipotassium phosphate (236 mg/1mL) + Monopotassium phosphate (224 mg/1mL)Injection, solutionIntravenousAmerican Regent1989-11-192013-04-01Us
Potassium PhosphatesDipotassium phosphate (236 mg/1mL) + Monopotassium phosphate (224 mg/1mL)Injection, solutionIntravenousFresenius Kabi2000-08-08Not applicableUs
Potassium PhosphatesDipotassium phosphate (236 mg/1mL) + Monopotassium phosphate (224 mg/1mL)Injection, solutionIntravenousAmerican Regent1989-11-192012-12-01Us
Potassium PhosphatesDipotassium phosphate (236 mg/1mL) + Monopotassium phosphate (224 mg/1mL)Injection, solution, concentrateIntravenousHospira, Inc.2005-08-26Not applicableUs
Potassium PhosphatesDipotassium phosphate (236 mg/1mL) + Monopotassium phosphate (224 mg/1mL)Injection, solutionIntravenousAmerican Regent1989-11-192013-02-01Us
Categories
UNII
CI71S98N1Z
CAS number
7758-11-4
Weight
Average: 174.1759
Monoisotopic: 173.888658754
Chemical Formula
HK2O4P
InChI Key
ZPWVASYFFYYZEW-UHFFFAOYSA-L
InChI
InChI=1S/2K.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2
IUPAC Name
dipotassium hydrogen phosphate
SMILES
[K+].[K+].OP([O-])([O-])=O

Pharmacology

Indication

As a food additive, dipotassium phosphate is used in imitation dairy creamers, dry powder beverages, mineral supplements, and starter cultures. It is used in non-dairy creamers to prevent coagulation. Dipotassium phosphate is also used to make buffer solutions and it is used in the production of trypticase soy agar which is used to make agar plates for culturing bacteria.

Associated Therapies
Pharmacodynamics

Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions.

Mechanism of action

Once phosphate gains access to the body fluids and tissues, it exerts little pharmacological effect. If the ion is introduced into the intestine, the absorbed phosphate is rapidly excreted. If large amounts are given by this route, much of it may escape absorption. Because this property leads to a cathartic action, phosphate salts are employed as mild laxatives.

Absorption

Potassium salts are well absorbed from gastro intestinal tract. Net phosphorus absorption may occur in the small intestine in some species but is primarily a function of the colon in horses.

Volume of distribution

Distribution is largely intracellular, but it is the intravascular concentration that is primarily responsible for toxicity.

Protein binding

Phosphate is minimally protein bound, and highly concentrated in cells (intracellular concentrations are 100-fold higher than serum concentrations). Concentrations of phosphate in plasma are higher in children than in adults.

Metabolism

Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues.

Route of elimination

Potassium is excreted primarily by kidney.

Half life

In healthy children with phosphate overdose, half-life was 4.8 to 10.6 hours, and was prolonged to 17 hours in a child with renal insufficiency.

Clearance

Phosphates are rapidly cleared by dialysis.

Toxicity

LD50 not available. Toxic effects in humans: Irritated skin, eye. Gastro intestinal irritation with nausea, vomiting, diarrhea, abdominal discomfort

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AcebutololDipotassium phosphate may increase the hyperkalemic activities of Acebutolol.
AceclofenacDipotassium phosphate may increase the hyperkalemic activities of Aceclofenac.
AcemetacinDipotassium phosphate may increase the hyperkalemic activities of Acemetacin.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Dipotassium phosphate.
Acetylsalicylic acidDipotassium phosphate may increase the hyperkalemic activities of Acetylsalicylic acid.
AclidiniumThe therapeutic efficacy of Dipotassium phosphate can be decreased when used in combination with Aclidinium.
AgmatineThe therapeutic efficacy of Dipotassium phosphate can be decreased when used in combination with Agmatine.
AlclofenacDipotassium phosphate may increase the hyperkalemic activities of Alclofenac.
AlcuroniumThe therapeutic efficacy of Dipotassium phosphate can be decreased when used in combination with Alcuronium.
AlfentanilThe therapeutic efficacy of Dipotassium phosphate can be decreased when used in combination with Alfentanil.
Food Interactions
Not Available

References

General References
  1. Wikipedia [Link]
  2. Pubchem [Link]
  3. Toxnet [Link]
  4. MSDS [Link]
External Links
KEGG Compound
C13197
PubChem Compound
24450
PubChem Substance
347827847
ChemSpider
22858
ChEBI
131527
ChEMBL
CHEMBL1200459
Wikipedia
Dipotassium_phosphate

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidIntravenous
LiquidBuccal
LiquidIntravesical
Injection, solutionIntravenous
Injection, solution, concentrateIntravenous
AerosolOral
PowderOral
InjectionIntravenous
SolutionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area83.42 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity12.41 m3·mol-1ChemAxon
Polarizability5.23 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as alkali metal phosphates. These are inorganic compounds in which the largest oxoanion is phosphate, and in which the heaviest atom not in an oxoanion is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal oxoanionic compounds
Sub Class
Alkali metal phosphates
Direct Parent
Alkali metal phosphates
Alternative Parents
Inorganic salts / Inorganic oxides
Substituents
Alkali metal phosphate / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
organic molecular entity (CHEBI:32031)

Enzymes

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Beta-ketoacyl-acyl-carrier-protein synthase ii activity
Specific Function
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to...
Gene Name
fabF
Uniprot ID
P0AAI5
Uniprot Name
3-oxoacyl-[acyl-carrier-protein] synthase 2
Molecular Weight
43045.39 Da
References
  1. Metacyc [Link]

Drug created on November 30, 2015 12:10 / Updated on November 02, 2018 07:02