Hydrocarbons, Acyclic

Organic compounds composed exclusively of carbon and hydrogen where no carbon atoms join to form a ring structure.
DrugDrug NameDrug Indication
DB00162Vitamin AFor the treatment of vitamin A deficiency.
DB00459AcitretinFor the treatment of severe psoriasis in adults.
DB00464Sodium Tetradecyl SulfateFor the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.
DB00523AlitretinoinFor topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.
DB00640AdenosineUsed as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT.
DB00659AcamprosateFor the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation
DB00735NaftifineFor the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.
DB00755TretinoinFor the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
DB00815Sodium lauryl sulfateSLS is used as a surfactant in shampoos and toothpastes. SLS also has microbicidal activities against both enveloped (Herpes simplex viruses, HIV-1, Semliki Forest virus) and nonenveloped (papillomaviruses, reovirus, rotavirus and poliovirus) viruses, although it has not been approved for this use.
DB00926EtretinateFor the treatment of severe psoriasis in adults.
DB00930ColesevelamFor use, alone or in combination with an HMG-CoA reductase inhibitor, as adjunctive therapy to diet and exercise for the reduction of elevated LDL cholesterol in patients with primary hypercholesterolemia (Fredrickson Type IIa).
DB00982IsotretinoinFor the treatment of severe recalcitrant nodular acne
DB01008BusulfanFor use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia (FDA has designated busulfan as an orphan drug for this use). It is also used as a component of pretransplant conditioning regimens in patients undergoing bone marrow transplantation for acute myeloid leukemia and nonmalignant diseases.
DB026994-OxoretinolNot Available
DB02877Arotinoid acidNot Available
DB03001PeridininNot Available
DB03006Arsanilic acidNot Available
DB031323-(2-Benzothiazolylthio)-1-Propanesulfonic AcidNot Available
DB03309N-CyclohexyltaurineNot Available
DB03460ViolaxanthinNot Available
DB03533GlycolurilNot Available
DB03635Ethanesulfonic AcidNot Available
DB03733Ethylene DichlorideNot Available
DB03967Dodecyl sulfateNot Available
DB04124AurodoxNot Available
DB04348Taurocholic AcidNot Available
DB04796InecalcitolInvestigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
DB05009ApadenosonInvestigated for use/treatment in cardiovascular disorders and inflammatory disorders (unspecified).
DB05076FenretinideInvestigated for use/treatment in macular degeneration.
DB05262OxypurinolIntended for the treatment of congestive heart failure and hyperuricemia.
DB05653IRX-5183Investigated for use/treatment in adverse effects (chemotherapy) and blood (blood forming organ disorders, unspecified).
DB05974TranscrocetinateInvestigated for use/treatment in cancer/tumors (unspecified), hemorrhage, hypoxia, respiratory failure, and strokes.
DB06197BimosiamoseInvestigated for use/treatment in asthma, psoriasis and psoriatic disorders, atopic dermatitis, inflammatory disorders (unspecified), and chronic obstructive pulmonary disease (COPD).
DB06218LacosamideLacosamide is indicated for adjunctive therapy for partial onset seizures in patients with epilepsy over 17 years old. Injection is indicated for short term use when oral therapy is not feasible.
DB06481ManitimusInvestigated for use/treatment in immunosuppressive and transplant (rejection).
DB06527TramiprosateInvestigated for use/treatment in strokes and alzheimer's disease.
DB06536TesaglitazarInvestigated for use/treatment in diabetes mellitus type 2.
DB06543AstaxanthinInvestigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma.
DB06755Beta caroteneBeta-carotene is FDA approved to be used as a nutrient supplement and to be even added in infant formula as a source of vitamin A.[L2191] It is also approved to be used as a color additive for food products,[L2192] drugs (with the label of "only as a color additive")[L2193] and cosmetics.[L2194] It is used commonly for the reduction of photosensitivity in patients with erythropoietic protoporphyria and other photosensitivity diseases.[A32485]
DB06774CapsaicinThe capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain.
DB06812Povidone-iodineFor topical application in the treatment and prevention of infection in wounds.
DB070313-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidNot Available
DB08455Ro 12-7310Not Available
DB08834Tauroursodeoxycholic acidUsed in the treatment of cholesterol gallstones. Tauroursodeoxycholic acid is also being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.
DB09110Coenzyme MMesna is a uroprotective agent and is used prophylactically to reduce ifosfamide and cyclophosphamide induced hemorrhagic cystitis. (2)
DB09120ZucapsaicinIndicated to be used in conjunction with oral COX-2 inhibitors or NSAIDs for the relief of severe pain in adult patients with osteoarthritis of the knee, not controlled with oral COX-2 inhibitors or NSAIDs alone, for a duration of no more than three months.
DB11060Polyvinyl alcoholFor use as a lubricant to prevent further irritation or to relieve dryness of the eye(s) [L2828].
DB11061PovidoneWhen in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.
DB11176ZeaxanthinNot Available
DB11231LycopeneNot Available
DB11324Nonivamide Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient [L2641], [A32884], [L2642].
DB11460SqualeneNot Available
DB11672CurcuminNo approved therapeutic indications.
DB11678TreosulfanNot Available
DB11874CrocinNot Available
DB12112Zuretinol acetateNot Available
DB12197AuricloseneNot Available
DB12311CP1-1189Not Available
DB12333SPK-843Not Available
DB12473TaurolidineNot Available
DB12582PiperineNot Available
DB1409713-cis-12-(3'-Carboxyphenyl)retinoic acidNot Available
DB141081,2-HexanediolNot Available
DB06405EprodisateInvestigated for use/treatment in amyloidosis.
DrugDrug NameTargetType
DB00162Vitamin ARetinol-binding protein 5carrier
DB00162Vitamin ARetinoid-binding protein 7carrier
DB00162Vitamin ARetinol-binding protein 4carrier
DB00162Vitamin ARetinol-binding protein 2carrier
DB00162Vitamin ASerum albumincarrier
DB00162Vitamin ACytochrome P450 1A1enzyme
DB00162Vitamin ACytochrome P450 26A1enzyme
DB00162Vitamin ARetinol dehydrogenase 12target
DB00162Vitamin ARetinol-binding protein 1target
DB00162Vitamin A11-cis retinol dehydrogenasetarget
DB00162Vitamin ARetinol dehydrogenase 13target
DB00162Vitamin ARetinol-binding protein 3target
DB00162Vitamin ARetinal dehydrogenase 2target
DB00162Vitamin ARetinal dehydrogenase 1target
DB00162Vitamin ARetinaldehyde-binding protein 1target
DB00162Vitamin ALecithin retinol acyltransferasetarget
DB00162Vitamin AShort-chain dehydrogenase/reductase 3target
DB00162Vitamin AAldehyde dehydrogenase family 1 member A3target
DB00162Vitamin AAll-trans-retinol 13,14-reductasetarget
DB00162Vitamin ARetinol dehydrogenase 11target
DB00162Vitamin ADehydrogenase/reductase SDR family member 4target
DB00162Vitamin ARetinol dehydrogenase 14target
DB00162Vitamin ARetinol dehydrogenase 8target
DB00162Vitamin AApolipoprotein Dtarget
DB00162Vitamin AHematopoietic prostaglandin D synthasetarget
DB00459AcitretinSerum albumincarrier
DB00459AcitretinCytochrome P450 26A1enzyme
DB00459AcitretinRetinoic acid receptor alphatarget
DB00459AcitretinRetinoic acid receptor RXR-betatarget
DB00459AcitretinRetinoic acid receptor gammatarget
DB00459AcitretinRetinoic acid receptor betatarget
DB00459AcitretinRetinoic acid receptor RXR-gammatarget
DB00459AcitretinRetinoic acid receptor RXR-alphatarget
DB00459AcitretinRetinol-binding protein 1target
DB00464Sodium Tetradecyl SulfateVitamin K-dependent protein Ctarget
DB00464Sodium Tetradecyl SulfateVitamin K-dependent protein Starget
DB00523AlitretinoinCellular retinoic acid-binding protein 2carrier
DB00523AlitretinoinCellular retinoic acid-binding protein 1carrier
DB00523AlitretinoinRetinoic acid receptor alphatarget
DB00523AlitretinoinRetinoic acid receptor RXR-betatarget
DB00523AlitretinoinRetinoic acid receptor gammatarget
DB00523AlitretinoinRetinoic acid receptor betatarget
DB00523AlitretinoinRetinoic acid receptor RXR-gammatarget
DB00523AlitretinoinRetinoic acid receptor RXR-alphatarget
DB00523AlitretinoinInsulin-like growth factor-binding protein 3target
DB00523AlitretinoinPregnancy-specific beta-1-glycoprotein 5target
DB00523AlitretinoinCytochrome P450 26C1target
DB00523AlitretinoinMultidrug resistance protein 1transporter
DB00640AdenosineAdenosine deaminaseenzyme
DB00640AdenosineAdenosine kinaseenzyme
DB00640AdenosineAdenosine receptor A3target
DB00640AdenosineAdenosine receptor A1target
DB00640AdenosineAdenosine receptor A2atarget
DB00640AdenosineAdenosine receptor A2btarget
DB00640AdenosineSolute carrier family 28 member 3transporter
DB00659AcamprosateMetabotropic glutamate receptor 5target
DB00659AcamprosateGABA-A receptor (anion channel)target
DB00659AcamprosateGlutamate (NMDA) receptortarget
DB00659AcamprosateProton-coupled amino acid transporter 1transporter
DB00735NaftifineSqualene monooxygenasetarget
DB00755TretinoinSerum albumincarrier
DB00755TretinoinCytochrome P450 2C8enzyme
DB00755TretinoinCytochrome P450 2B6enzyme
DB00755TretinoinCytochrome P450 3A4enzyme
DB00755TretinoinCytochrome P450 3A5enzyme
DB00755TretinoinCytochrome P450 2A6enzyme
DB00755TretinoinCytochrome P450 3A7enzyme
DB00755TretinoinCytochrome P450 2C18enzyme
DB00755TretinoinCytochrome P450 2C9enzyme
DB00755TretinoinCytochrome P450 4A11enzyme
DB00755TretinoinCytochrome P450 1A1enzyme
DB00755TretinoinRetinoic acid receptor gammatarget
DB00755TretinoinRetinoic acid receptor RXR-betatarget
DB00755TretinoinRetinal dehydrogenase 1target
DB00755TretinoinRetinoic acid-induced protein 3target
DB00755TretinoinRetinoic acid receptor RXR-gammatarget
DB00755TretinoinNuclear receptor subfamily 0 group B member 1target
DB00755TretinoinRetinal dehydrogenase 2target
DB00755TretinoinRetinoic acid receptor responder protein 1target
DB00755TretinoinRetinoic acid receptor alphatarget
DB00755TretinoinRetinoic acid receptor betatarget
DB00755TretinoinLipocalin-1target
DB00755TretinoinOdorant-binding protein 2atarget
DB00755TretinoinRetinol-binding protein 4target
DB00755Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
DB00755TretinoinRetinoic acid receptor RXR-alphatarget
DB00755TretinoinCytochrome P450 26A1target
DB00755TretinoinCytochrome P450 26B1target
DB00755TretinoinCytochrome P450 26C1target
DB00755TretinoinHematopoietic prostaglandin D synthasetarget
DB00755TretinoinCellular retinoic acid-binding protein 1transporter
DB00755TretinoinCellular retinoic acid-binding protein 2transporter
DB00815Sodium lauryl sulfateSerum albumincarrier
DB00926EtretinateCellular retinoic acid-binding protein 1carrier
DB00926EtretinateCytochrome P450 19A1enzyme
DB00926EtretinateCytochrome P450 26A1enzyme
DB00926EtretinateRetinoic acid receptor alphatarget
DB00926EtretinateRetinoic acid receptor RXR-betatarget
DB00926EtretinateRetinoic acid receptor gammatarget
DB00926EtretinateRetinoic acid receptor betatarget
DB00926EtretinateRetinoic acid receptor RXR-gammatarget
DB00926EtretinateRetinoic acid receptor RXR-alphatarget
DB00930ColesevelamBile acidstarget
DB00982IsotretinoinRetinoic acid receptor alphatarget
DB01008BusulfanCytochrome P450 3A4enzyme
DB01008BusulfanGlutathione S-transferase A2enzyme
DB01008BusulfanGlutathione S-transferase A1enzyme
DB01008BusulfanGlutathione S-transferase Mu 1enzyme
DB01008BusulfanGlutathione S-transferase Penzyme
DB01008BusulfanMicrosomal glutathione S-transferase 2enzyme
DB01008BusulfanDNAtarget
DB02877Arotinoid acidRetinoic acid receptor betatarget
DB03006Arsanilic acidLysozyme Ctarget
DB031323-(2-Benzothiazolylthio)-1-Propanesulfonic AcidTriosephosphate isomerase, glycosomaltarget
DB031323-(2-Benzothiazolylthio)-1-Propanesulfonic AcidTriosephosphate isomerasetarget
DB03309N-CyclohexyltaurineSulfotransferase family cytosolic 2B member 1target
DB03309N-CyclohexyltaurineNitrite reductasetarget
DB03309N-CyclohexyltaurineHomeobox protein engrailed-2target
DB03309N-CyclohexyltaurineRibonuclease PHtarget
DB03309N-CyclohexyltaurineCyanovirin-Ntarget
DB03309N-CyclohexyltaurinePhosphoproteintarget
DB03533GlycolurilStreptavidintarget
DB03635Ethanesulfonic AcidPlatelet basic proteintarget
DB03635Ethanesulfonic AcidPhosphonoacetaldehyde hydrolasetarget
DB03733Ethylene DichlorideHaloalkane dehalogenasetarget
DB03967Dodecyl sulfateLysozyme Ctarget
DB03967Dodecyl sulfateLipid A palmitoyltransferase PagPtarget
DB04124AurodoxElongation factor Tu-Btarget
DB04348Taurocholic AcidBile salt-activated lipasetarget
DB04348Taurocholic AcidGastrotropintarget
DB04348Taurocholic AcidBile acid receptortarget
DB04348Taurocholic AcidBile salt export pumptransporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB04348Taurocholic AcidIleal sodium/bile acid cotransportertransporter
DB04348Taurocholic AcidCanalicular multispecific organic anion transporter 1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1B1transporter
DB04348Taurocholic AcidSolute carrier family 22 member 1transporter
DB04348Taurocholic AcidCanalicular multispecific organic anion transporter 2transporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 4transporter
DB04348Taurocholic AcidMultidrug resistance protein 1transporter
DB04348Taurocholic AcidSolute carrier family 22 member 6transporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 7transporter
DB04348Taurocholic AcidSolute carrier family 22 member 8transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 4A1transporter
DB04348Taurocholic AcidATP-binding cassette sub-family C member 11transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1C1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 3A1transporter
DB04348Taurocholic AcidATP-binding cassette sub-family G member 2transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 2B1transporter
DB04348Taurocholic AcidMonocarboxylate transporter 1transporter
DB04348Taurocholic AcidSodium/bile acid cotransportertransporter
DB04348Taurocholic AcidOrganic solute transporter subunit alphatransporter
DB04348Taurocholic AcidOrganic solute transporter subunit betatransporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1B3transporter
DB04348Taurocholic AcidCystine/glutamate transportertransporter
DB04796InecalcitolVitamin D3 receptortarget
DB05009ApadenosonAdenosine receptor A2atarget
DB05076FenretinideRetinol-binding protein 4carrier
DB05262OxypurinolXanthine dehydrogenase/oxidasetarget
DB06218LacosamideCytochrome P450 2C19enzyme
DB06218LacosamideCytochrome P450 2C9enzyme
DB06218LacosamideCytochrome P450 3A4enzyme
DB06218LacosamideSodium channel protein type 9 subunit alphatarget
DB06218LacosamideSodium channel protein type 3 subunit alphatarget
DB06218LacosamideSodium channel protein type 10 subunit alphatarget
DB06481ManitimusDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB06536TesaglitazarPeroxisome proliferator-activated receptor alphatarget
DB06536TesaglitazarPeroxisome proliferator-activated receptor gammatarget
DB06543AstaxanthinNF-kappa-B inhibitor alphatarget
DB06755Beta caroteneVery low-density lipoprotein receptorcarrier
DB06755Beta caroteneRetinol-binding protein 1carrier
DB06755Beta caroteneRetinol-binding protein 2carrier
DB06755Beta caroteneRetinol-binding protein 3carrier
DB06755Beta caroteneRetinol-binding protein 4carrier
DB06755Beta caroteneRetinol-binding protein 5carrier
DB06755Beta caroteneBeta,beta-carotene 15,15'-dioxygenaseenzyme
DB06755Beta caroteneFree radicalstarget
DB06774CapsaicinCytochrome P450 3A4enzyme
DB06774CapsaicinProstaglandin G/H synthase 2enzyme
DB06774CapsaicinMyeloperoxidaseenzyme
DB06774CapsaicinCytochrome P450 1A2enzyme
DB06774CapsaicinCytochrome P450 2E1enzyme
DB06774CapsaicinAmine oxidase [flavin-containing] Aenzyme
DB06774CapsaicinDopamine beta-hydroxylaseenzyme
DB06774CapsaicinGlutamine synthetaseenzyme
DB06774CapsaicinCholinesteraseenzyme
DB06774CapsaicinTransient receptor potential cation channel subfamily V member 1target
DB06774CapsaicinProhibitin-2target
DB070313-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidRetinoic acid receptor gammatarget
DB08455Ro 12-7310Cellular retinoic acid-binding protein 2carrier
DB08834Tauroursodeoxycholic acidCytochrome P450 3A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 3A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B9enzyme
DB08834Tauroursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08834Tauroursodeoxycholic acidCystine/glutamate transportertransporter
DB09110Coenzyme MGlutathione reductase, mitochondrialenzyme
DB09120ZucapsaicinCytochrome P450 1A2enzyme
DB09120ZucapsaicinCytochrome P450 2C19enzyme
DB09120ZucapsaicinCytochrome P450 2C9enzyme
DB09120ZucapsaicinCytochrome P450 2E1enzyme
DB09120ZucapsaicinTransient receptor potential cation channel subfamily V member 1target
DB11324NonivamideTransient receptor potential cation channel subfamily V member 1target
DB11672CurcuminCytochrome P450 2C9enzyme
DB11672CurcuminCytochrome P450 3A4enzyme
DB11672CurcuminCytochrome P450 2B6enzyme
DB11672CurcuminCytochrome P450 1A2enzyme
DB11672CurcuminCytochrome P450 2D6enzyme
DB11672CurcuminGlutathione S-transferase A1enzyme
DB11672CurcuminGlutathione S-transferase Mu 1enzyme
DB11672CurcuminGlutathione S-transferase Penzyme
DB11672CurcuminPeroxisome proliferator-activated receptor gammatarget
DB11672CurcuminVitamin D3 receptortarget
DB11672CurcuminMultidrug resistance-associated protein 5target
DB11672CurcuminCarbonyl reductase [NADPH] 1target
DB11672CurcuminGlutathione S-transferase Ptarget
DB11672CurcuminMultidrug resistance protein 1transporter
DB12582PiperineCytochrome P450 2C9enzyme
DB12582PiperineNuclear receptor subfamily 1 group I member 2target