Refractory Mantle Cell Lymphoma

Also known as: Mantle Cell Lymphoma Refractory

DrugDrug NameDrug Description
DB06769BendamustineBendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
DrugDrug NameTargetType
DB06769BendamustineCytochrome P450 1A2enzyme
DrugDrug NamePhaseStatusCount
DB11666Buparlisib0Completed1
DB09053Ibrutinib0Recruiting1
DB05220Alisertib1Active Not Recruiting1
DB05220Alisertib1Completed1
DB11945Avelumab1Recruiting1
DB09052Blinatumomab1Suspended1
DB00188Bortezomib1Active Not Recruiting1
DB00958Carboplatin1Recruiting1
DB00531Cyclophosphamide1Not Yet Recruiting1
DB00773Etoposide1Recruiting1
DB01073Fludarabine1Not Yet Recruiting1
DB09053Ibrutinib1Active Not Recruiting1
DB09053Ibrutinib1Completed1
DB09053Ibrutinib1Recruiting2
DB01181Ifosfamide1Recruiting1
DB00480Lenalidomide1Active Not Recruiting1
DB00480Lenalidomide1Suspended1
DB06132Nivolumab1Active Not Recruiting1
DB09035Nivolumab1Active Not Recruiting1
DB09037Pembrolizumab1Completed1
DB11759Pevonedistat1Recruiting1
DB00073Rituximab1Active Not Recruiting1
DB00073Rituximab1Recruiting1
DB06176Romidepsin1Completed1
DB06273Tocilizumab1Not Yet Recruiting1
DB15113Utomilumab1Recruiting1
DB07232Veliparib1Active Not Recruiting1
DB00262Carmustine1 / 2Active Not Recruiting1
DB00493Cefotaxime1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting1
DB00987Cytarabine1 / 2Active Not Recruiting1
DB00773Etoposide1 / 2Active Not Recruiting1
DB01073Fludarabine1 / 2Recruiting1
DB00480Lenalidomide1 / 2Recruiting1
DB01042Melphalan1 / 2Active Not Recruiting1
DB06132Nivolumab1 / 2Recruiting1
DB09035Nivolumab1 / 2Recruiting1
DB14844ONC-2011 / 2Recruiting1
DB11942Selinexor1 / 2Recruiting1
DB06287Temsirolimus1 / 2Completed1
DB11703Acalabrutinib2Not Yet Recruiting1
DB00493Cefotaxime2Active Not Recruiting1
DB00091Ciclosporin2Active Not Recruiting1
DB00531Cyclophosphamide2Active Not Recruiting1
DB01073Fludarabine2Active Not Recruiting1
DB09053Ibrutinib2Recruiting3
DB00688Mycophenolate mofetil2Active Not Recruiting1
DB08935Obinutuzumab2Recruiting1
DB06306Onalespib2Recruiting1
DB00073Rituximab2Recruiting1
DB11581Venetoclax2Not Yet Recruiting1
DB05094EnzalutamideNot AvailableActive Not Recruiting1
DB08899EnzalutamideNot AvailableActive Not Recruiting1