Ocular Hypertension

Also known as: Hypertension Ocular / Intraocular pressure high / Intraocular hypertension / Intraocular pressure raised / Ocular Hypertension (OHT) / Ocular Hypertension (OH) / Hypertension, Ocular / Elevated Intraocular Pressure / Intraocular pressure increased / IOP increased / Raised IOP / Ocular tension increased / Tension ocular increased / Pressure intraocular increased / Increased intraocular pressure

DrugDrug NameDrug Description
DB00964ApraclonidineAn alpha adrenergic agonist used to treat raised intraocular pressure.
DB00195BetaxololA cardioselective beta blocking agent commonly used to treat hypertension and elevated intraocular pressure (when administered ophthalmically).
DB00905BimatoprostA prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension.
DB00484BrimonidineAn alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea.
DB01194BrinzolamideA carbonic anhydrase inhibitor used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB00521CarteololA beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma.
DB01144DiclofenamideA carbonic anhydrase inhibitor used for the management of open-angle and secondary glaucoma, as well as acute angle-closure glaucoma in delayed pre-operative setting requiring a reduction in intraocular pressure.
DB00449DipivefrinA prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma.
DB00869DorzolamideA carbonic anhydrase inhibitor used to treat high intraocular pressure in ocular hypertension and open angle glaucoma.
DB00654LatanoprostAn isopropyl ester prodrug used to treat increased intraocular pressure.
DB01210LevobunololA beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB01214MetipranololA beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB13931NetarsudilA rho kinase inhibitor used to reduce intraocular pressure in patients with open angle glaucoma or ocular hypertension.
DB01085PilocarpineA muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy.
DB08819TafluprostAn ophthalmic prostaglandin analog used to lower intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB00373TimololA non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma.
DB00287TravoprostA prostaglandin analog used in the treatment of elevated intraocular pressure due to open angle glaucoma or ocular hypertension.
DB06826UnoprostoneA prostaglandin analogue used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are clinically unresponsive to other ocular antihypertensive agents.
DrugDrug NameTargetType
DB00964ApraclonidineAlpha-2A adrenergic receptortarget
DB00964ApraclonidineAlpha-1A adrenergic receptortarget
DB00964ApraclonidineAlpha-2B adrenergic receptortarget
DB00195BetaxololBeta-1 adrenergic receptortarget
DB00195BetaxololBeta-2 adrenergic receptortarget
DB00195BetaxololCytochrome P450 1A2enzyme
DB00195BetaxololCytochrome P450 2D6enzyme
DB00905BimatoprostProstaglandin F2-alpha receptortarget
DB00905BimatoprostProstaglandin E2 receptor EP1 subtypetarget
DB00905BimatoprostProstaglandin E2 receptor EP3 subtypetarget
DB00905BimatoprostCytochrome P450 3A4enzyme
DB00905BimatoprostCytochrome P450 3A5enzyme
DB00484BrimonidineAlpha-2A adrenergic receptortarget
DB00484BrimonidineAlpha-2B adrenergic receptortarget
DB00484BrimonidineAlpha-2C adrenergic receptortarget
DB00484BrimonidineAldehyde oxidaseenzyme
DB01194BrinzolamideCarbonic anhydrase 1target
DB01194BrinzolamideCarbonic anhydrase 2target
DB01194BrinzolamideCytochrome P450 3A4enzyme
DB01194BrinzolamideCarbonic anhydrase 5A, mitochondrialtarget
DB01194BrinzolamideCarbonic anhydrase 4target
DB01194BrinzolamideCarbonic anhydrase 3target
DB00521CarteololBeta-2 adrenergic receptortarget
DB00521CarteololBeta-1 adrenergic receptortarget
DB00521CarteololCytochrome P450 2D6enzyme
DB01144DiclofenamideCarbonic anhydrase 1target
DB01144DiclofenamideCarbonic anhydrase 4target
DB01144DiclofenamideCarbonic anhydrase 2target
DB01144DiclofenamideCarbonic anhydrase 7target
DB01144DiclofenamideCarbonic anhydrase 3target
DB00449DipivefrinAlpha-2A adrenergic receptortarget
DB00449DipivefrinCholinesterasetarget
DB00449DipivefrinBeta-2 adrenergic receptortarget
DB00449DipivefrinAlpha-1A adrenergic receptortarget
DB00449DipivefrinAcetylcholinesterasetarget
DB00869DorzolamideCarbonic anhydrase 2target
DB00869DorzolamideCarbonic anhydrase 1target
DB00869DorzolamideCarbonic anhydrase 4target
DB00869DorzolamideCytochrome P450 2C9enzyme
DB00869DorzolamideCarbonic anhydrase 3target
DB00654LatanoprostProstaglandin F2-alpha receptortarget
DB00654LatanoprostSolute carrier organic anion transporter family member 2A1transporter
DB00654LatanoprostSolute carrier family 22 member 6transporter
DB00654LatanoprostSolute carrier family 22 member 8transporter
DB00654LatanoprostCorneal esterasesenzyme
DB01210LevobunololBeta-1 adrenergic receptortarget
DB01210LevobunololBeta-2 adrenergic receptortarget
DB01210LevobunololCytochrome P450 2D6enzyme
DB01214MetipranololBeta-1 adrenergic receptortarget
DB01214MetipranololBeta-2 adrenergic receptortarget
DB01214MetipranololCytochrome P450 2D6enzyme
DB13931NetarsudilRho-associated protein kinase 1target
DB13931NetarsudilRho-associated protein kinase 2target
DB13931NetarsudilSodium-dependent noradrenaline transportertarget
DB01085PilocarpineMuscarinic acetylcholine receptor M1target
DB01085PilocarpineMuscarinic acetylcholine receptor M2target
DB01085PilocarpineCytochrome P450 2A6enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M3target
DB01085PilocarpineCytochrome P450 3A4enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M4target
DB08819TafluprostProstaglandin F2-alpha receptortarget
DB08819TafluprostProstaglandin G/H synthase 2enzyme
DB00373TimololBeta-1 adrenergic receptortarget
DB00373TimololBeta-2 adrenergic receptortarget
DB00373TimololCytochrome P450 2D6enzyme
DB00373TimololP-glycoprotein 1transporter
DB00373TimololCytochrome P450 2C19enzyme
DB00373TimololLysozymetarget
DB00287TravoprostProstaglandin F2-alpha receptortarget
DrugDrug NamePhaseStatusCount
DB12256Bamosiran1Completed1
DB00484Brimonidine1Completed1
DB00521Carteolol1Completed1
DB00869Dorzolamide1Completed1
DB00654Latanoprost1Completed3
DB00654Latanoprost1Terminated1
DB12043Sepetaprost1Completed1
DB08819Tafluprost1Completed1
DB00373Timolol1Completed2
DB00287Travoprost1Completed1
DB12256Bamosiran1 / 2Completed1
DB00905Bimatoprost1 / 2Completed3
DB05757DNB-0011 / 2Completed1
DB12116Epigallocatechin gallate1 / 2Unknown Status1
DB12295Evodenoson1 / 2Completed1
DB00654Latanoprost1 / 2Completed5
DB12977Simenepag isopropyl1 / 2Completed1
DB00373Timolol1 / 2Completed3
DB00373Timolol1 / 2Recruiting1
DB00373Timolol1 / 2Unknown Status1
DB13122Trabodenoson1 / 2Completed1
DB05288Anecortave acetate2Terminated1
DB12256Bamosiran2Completed2
DB11105Benzalkonium2Completed1
DB00905Bimatoprost2Completed12
DB00484Brimonidine2Completed4
DB00484Brimonidine2Terminated1
DB01194Brinzolamide2Completed4
DB01194Brinzolamide2Terminated1
DB00869Dorzolamide2Completed1
DB00654Latanoprost2Completed31
DB00654Latanoprost2Recruiting1
DB00654Latanoprost2Withdrawn2
DB11660Latanoprostene bunod2Completed1
DB13931Netarsudil2Completed5
DB15071Omidenepag isopropyl2Completed1
DB05746PF-031872072Completed2
DB00692Phentolamine2Completed1
DB05511Piclidenoson2Completed1
DB06195Seliciclib2Completed1
DB12043Sepetaprost2Completed1
DB12977Simenepag isopropyl2Completed2
DB12623Taprenepag2Completed2
DB00373Timolol2Completed13
DB13122Trabodenoson2Completed2
DB00287Travoprost2Completed9
DB00287Travoprost2Terminated1
DB00905Bimatoprost2 / 3Completed1
DB00654Latanoprost2 / 3Completed1
DB15071Omidenepag isopropyl2 / 3Completed1
DB00195Betaxolol3Completed2
DB00195Betaxolol3Recruiting1
DB00905Bimatoprost3Active Not Recruiting1
DB00905Bimatoprost3Completed10
DB00905Bimatoprost3Enrolling by Invitation1
DB00905Bimatoprost3Recruiting3
DB00905Bimatoprost3Withdrawn1
DB00484Brimonidine3Completed16
DB00484Brimonidine3Not Yet Recruiting1
DB00484Brimonidine3Recruiting1
DB00484Brimonidine3Withdrawn1
DB01194Brinzolamide3Completed9
DB01194Brinzolamide3Recruiting1
DB01194Brinzolamide3Terminated2
DB01194Brinzolamide3Withdrawn1
DB00521Carteolol3Completed1
DB00869Dorzolamide3Completed7
DB00869Dorzolamide3Terminated1
DB00869Dorzolamide3Withdrawn1
DB00654Latanoprost3Completed27
DB00654Latanoprost3Not Yet Recruiting1
DB00654Latanoprost3Recruiting1
DB00654Latanoprost3Terminated2
DB00654Latanoprost3Withdrawn2
DB11660Latanoprostene bunod3Completed3
DB09351Levobetaxolol3Completed1
DB09351Levobetaxolol3Recruiting1
DB13931Netarsudil3Completed6
DB13931Netarsudil3Recruiting1
DB01165Ofloxacin3Recruiting1
DB01085Pilocarpine3Recruiting1
DB00860Prednisolone3Recruiting1
DB08819Tafluprost3Completed7
DB00373Timolol3Active Not Recruiting1
DB00373Timolol3Completed54
DB00373Timolol3Not Yet Recruiting1
DB00373Timolol3Terminated2
DB00373Timolol3Withdrawn1
DB13122Trabodenoson3Completed1
DB00287Travoprost3Completed20
DB00287Travoprost3Recruiting2
DB00287Travoprost3Terminated2
DB00287Travoprost3Withdrawn1
DB00905Bimatoprost4Completed27
DB00905Bimatoprost4Recruiting2
DB00905Bimatoprost4Withdrawn1
DB00484Brimonidine4Completed17
DB00484Brimonidine4Terminated1
DB01194Brinzolamide4Completed17
DB01194Brinzolamide4Terminated1
DB01234Dexamethasone4Completed1
DB00869Dorzolamide4Completed14
DB00869Dorzolamide4Terminated1
DB00588Fluticasone propionate4Completed1
DB11075Hypromellose4Completed4
DB00654Latanoprost4Completed29
DB00654Latanoprost4Recruiting3
DB00654Latanoprost4Unknown Status1
DB00654Latanoprost4Withdrawn1
DB11660Latanoprostene bunod4Not Yet Recruiting1
DB14596Loteprednol etabonate4Completed1
DB13931Netarsudil4Completed1
DB11077Polyethylene glycol 4004Completed1
DB00860Prednisolone4Unknown Status1
DB01839Propylene glycol4Completed1
DB08819Tafluprost4Completed5
DB08819Tafluprost4Recruiting1
DB08819Tafluprost4Withdrawn1
DB00373Timolol4Completed36
DB00373Timolol4Terminated2
DB00373Timolol4Withdrawn3
DB00684Tobramycin4Completed1
DB00287Travoprost4Completed31
DB00287Travoprost4Not Yet Recruiting1
DB00287Travoprost4Terminated3
DB00287Travoprost4Withdrawn3
DB00964ApraclonidineNot AvailableUnknown Status1
DB00905BimatoprostNot AvailableCompleted12
DB00905BimatoprostNot AvailableUnknown Status1
DB00484BrimonidineNot AvailableCompleted4
DB00484BrimonidineNot AvailableNot Yet Recruiting1
DB00484BrimonidineNot AvailableUnknown Status1
DB01194BrinzolamideNot AvailableCompleted1
DB01194BrinzolamideNot AvailableUnknown Status1
DB00869DorzolamideNot AvailableUnknown Status1
DB00869DorzolamideNot AvailableWithdrawn1
DB01050IbuprofenNot AvailableCompleted1
DB00654LatanoprostNot AvailableCompleted5
DB00654LatanoprostNot AvailableNot Yet Recruiting1
DB00654LatanoprostNot AvailableUnknown Status4
DB00654LatanoprostNot AvailableWithdrawn1
DB14596Loteprednol etabonateNot AvailableCompleted1
DB01085PilocarpineNot AvailableCompleted1
DB01085PilocarpineNot AvailableUnknown Status1
DB00373TimololNot AvailableCompleted9
DB00373TimololNot AvailableNot Yet Recruiting1
DB00373TimololNot AvailableUnknown Status1
DB00373TimololNot AvailableWithdrawn1
DB00684TobramycinNot AvailableCompleted1
DB00287TravoprostNot AvailableCompleted3
DB00287TravoprostNot AvailableUnknown Status1