Ocular Hypertension

Also known as: Intraocular pressure raised / Ocular Hypertension (OHT) / Hypertension Ocular / Hypertension, Ocular / Intraocular pressure high / Intraocular hypertension / Ocular Hypertension (OH) / Elevated intraoccular pressure / Intraocular pressure increased / IOP increased / Raised IOP / Ocular tension increased / Tension ocular increased / Pressure intraocular increased / Increased intraocular pressure

DrugDrug NameDrug Description
DB00964ApraclonidineApraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
DB00195BetaxololA cardioselective beta-1-adrenergic antagonist with no partial agonist activity.
DB00905BimatoprostBimatoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes. It binds to the prostanoid FP receptor.
DB00484BrimonidineBrimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996.[A178951] It is considered to be a third generation alpha-2 aadrenergic receptor agonist, since it displays preferential binding at alpha-2 adrenoceptors over alpha-1 receptors.[A179002] Brimonidine displays a higher selectivity toward the alpha-2 adrenergic receptors than [clonidine] or [apraclonidine], which are also alpha-2 adrenergic agonists.[A178969] Alpha-2 adrenergic agonists are members of the ocular hypotensive agent drug class that are used in the chronic treatment of glaucoma. Early treatment and management of glaucoma, which predominantly involves the lowering of intraocular pressure, is critical since glaucoma is considered to be a common cause of blindness worldwide.[A178948,A178969] Ophthalmically, brimonidine is used to lower intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. Because it is oxidately stable, brimonidine is associated with fewer reports of ocular allergic reactions compared to other alpha-2 adrenergic agonists.[A178969] The ophthalmic solution of brimonidine was first approved by the FDA in 1996 as Alphagan [label] and brimonidine is the only selective alpha-adrenergic receptor agonist approved for chronic treatment in glaucoma.[A36674] Brimonidine is also found in ophthalmic solutions in combination with [brinzolamide] under the market name Simbrinza for the reduction in intraocular pressure. Unlike nonselective beta-blockers used in ocular hypertension, brimonidine is not associated with significantly adverse cardiopulmonary side effects.[A178945] Thus brimonidine is an effective and safe alternative to beta-blockers, in patients with, or at high risk for, cardiopulmonary disease.[A178948] The topical form of brimonidine was approved by the FDA in August 2013 for the symptomatic treatment of persistent facial erythema of rosacea in adults. It is marketed under the brand name Mirvaso.[L6535] Brimonidine is the first topical treatment approved for facial erythema of rosacea.[A178978]
DB01194BrinzolamideBrinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase inhibitor. Carbonic anhydrase (CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II (CA-II). Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure. Brinzolamide is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB00521CarteololA beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.
DB00449DipivefrinDipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).
DB00869DorzolamideDorzolamide is a carbonic anhydrase (CA) inhibitor. It is used in ophthalmic solutions (Trusopt) to lower intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.
DB00654LatanoprostLatanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes. It is also known by the brand name of Xalatan manufactured by Pfizer.
DB01210LevobunololA nonselective beta-adrenoceptor antagonist used in the treatment of glaucoma.
DB01214MetipranololA beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
DB13931NetarsudilA Rho kinase inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous As of December 18, 2017 the FDA approved Aerie Pharmaceutical's Rhopressa (netarsudil ophthalmic solution) 0.02% for the indication of reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Acting as both a rho kinase inhibitor and a norepinephrine transport inhibitor, Netarsudil is a novel glaucoma medication in that it specifically targets the conventional trabecular pathway of aqueous humour outflow to act as an inhibitor to the rho kinase and norepinephrine transporters found there as opposed to affecting protaglandin F2-alpha analog like mechanisms in the unconventional uveoscleral pathway that many other glaucoma medications demonstrate.
DB08819TafluprostA prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012.
DB00373TimololA beta-adrenergic antagonist similar in action to propranolol. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor.
DB00287TravoprostTravoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure [FDA Label]. It is a synthetic prostaglandin F2alpha analog [FDA Label]. Having been a well-received therapeutic agent with demonstrated efficacy and safety, travoprost is currently approved by the US FDA as a first-line treatment for lowering intraocular pressure in patients with open-angle glaucoma or ocular hypotension [L5155]. Furthermore, this approval also solidifies the medication as the first and only prostaglandin analog approved by the FDA for first-line treatment of glaucoma patients that does not contain the preservative benzalkonium chloride [L5155]. Moreover, travoprost is also currently approved in the EU for the decrease of elevated intraocular pressure in paediatric patients aged 2 months to < 18 years with ocular hypertension or paediatric glaucoma [L5146, L5152].
DB06826UnoprostoneUnoprostone isopropyl is a prostaglandin analogue. Ophthalmic Solution 0.15% is a synthetic docosanoid. Unoprostone isopropyl has the chemical name isopropyl (+)-(Z)-7-[(1R,2R,3R,5S)-3,5 dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoate. The main indication of Unoprostane is treatment of glucoma.
DrugDrug NameTargetType
DB00964ApraclonidineAlpha-2A adrenergic receptortarget
DB00964ApraclonidineAlpha-1A adrenergic receptortarget
DB00964ApraclonidineAlpha-2B adrenergic receptortarget
DB00195BetaxololBeta-1 adrenergic receptortarget
DB00195BetaxololBeta-2 adrenergic receptortarget
DB00195BetaxololCytochrome P450 1A2enzyme
DB00195BetaxololCytochrome P450 2D6enzyme
DB00905BimatoprostProstaglandin F2-alpha receptortarget
DB00905BimatoprostProstaglandin E2 receptor EP1 subtypetarget
DB00905BimatoprostProstaglandin E2 receptor EP3 subtypetarget
DB00905BimatoprostAldo-keto reductase family 1 member C3target
DB00484BrimonidineAlpha-2A adrenergic receptortarget
DB00484BrimonidineAlpha-2B adrenergic receptortarget
DB00484BrimonidineAlpha-2C adrenergic receptortarget
DB00484BrimonidineAldehyde oxidaseenzyme
DB01194BrinzolamideCarbonic anhydrase 1target
DB01194BrinzolamideCarbonic anhydrase 2target
DB01194BrinzolamideCytochrome P450 3A4enzyme
DB01194BrinzolamideCarbonic anhydrase 5A, mitochondrialtarget
DB01194BrinzolamideCarbonic anhydrase 4target
DB01194BrinzolamideCarbonic anhydrase 3target
DB00521CarteololBeta-2 adrenergic receptortarget
DB00521CarteololBeta-1 adrenergic receptortarget
DB00521CarteololCytochrome P450 2D6enzyme
DB00449DipivefrinAlpha-2A adrenergic receptortarget
DB00449DipivefrinCholinesterasetarget
DB00449DipivefrinBeta-2 adrenergic receptortarget
DB00449DipivefrinAlpha-1A adrenergic receptortarget
DB00449DipivefrinAcetylcholinesterasetarget
DB00869DorzolamideCarbonic anhydrase 2target
DB00869DorzolamideCarbonic anhydrase 1target
DB00869DorzolamideCarbonic anhydrase 4target
DB00869DorzolamideCytochrome P450 2C9enzyme
DB00869DorzolamideCytochrome P450 3A4enzyme
DB00869DorzolamideCarbonic anhydrase 3target
DB00654LatanoprostProstaglandin F2-alpha receptortarget
DB00654LatanoprostSolute carrier organic anion transporter family member 2B1transporter
DB00654LatanoprostSolute carrier family 22 member 1transporter
DB01210LevobunololBeta-1 adrenergic receptortarget
DB01210LevobunololBeta-2 adrenergic receptortarget
DB01210LevobunololCytochrome P450 2D6enzyme
DB01214MetipranololBeta-1 adrenergic receptortarget
DB01214MetipranololBeta-2 adrenergic receptortarget
DB01214MetipranololCytochrome P450 2D6enzyme
DB13931NetarsudilRho-associated protein kinase 1target
DB13931NetarsudilRho-associated protein kinase 2target
DB13931Netarsudilsolute carrier family 6 member 2target
DB08819TafluprostProstaglandin F2-alpha receptortarget
DB08819TafluprostProstaglandin G/H synthase 2enzyme
DB00373TimololBeta-1 adrenergic receptortarget
DB00373TimololBeta-2 adrenergic receptortarget
DB00373TimololCytochrome P450 2D6enzyme
DB00373TimololMultidrug resistance protein 1transporter
DB00373TimololCytochrome P450 2C19enzyme
DB00373TimololLysozymetarget
DB00287TravoprostProstaglandin F2-alpha receptortarget
DrugDrug NamePhaseStatusCount
DB12256Bamosiran1Completed1
DB00484Brimonidine1Completed1
DB00869Dorzolamide1Completed1
DB00654Latanoprost1Completed3
DB00654Latanoprost1Terminated1
DB12043Sepetaprost1Completed1
DB08819Tafluprost1Completed1
DB00373Timolol1Completed2
DB00287Travoprost1Completed1
DB12256Bamosiran1 / 2Completed1
DB00905Bimatoprost1 / 2Completed3
DB11121Chloroxylenol1 / 2Completed1
DB05757DNB-0011 / 2Completed1
DB12295Evodenoson1 / 2Completed1
DB00654Latanoprost1 / 2Completed3
DB12977Simenepag isopropyl1 / 2Completed1
DB00373Timolol1 / 2Completed3
DB00373Timolol1 / 2Unknown Status1
DB13122Trabodenoson1 / 2Completed1
DB12256Bamosiran2Completed1
DB00905Bimatoprost2Completed11
DB00484Brimonidine2Completed2
DB00484Brimonidine2Terminated1
DB01194Brinzolamide2Completed4
DB01194Brinzolamide2Terminated1
DB00869Dorzolamide2Completed1
DB00125L-Arginine2Completed1
DB00654Latanoprost2Completed22
DB00654Latanoprost2Recruiting1
DB00654Latanoprost2Withdrawn1
DB11660Latanoprostene Bunod2Completed1
DB13931Netarsudil2Completed4
DB13931Netarsudil2Recruiting1
DB15071Omidenepag isopropyl2Completed1
DB05746PF-031872072Completed2
DB00692Phentolamine2Recruiting1
DB05511Piclidenoson2Completed1
DB06195Seliciclib2Completed1
DB12043Sepetaprost2Completed1
DB12977Simenepag isopropyl2Completed2
DB12623Taprenepag2Completed1
DB00373Timolol2Completed11
DB13122Trabodenoson2Completed1
DB00287Travoprost2Completed9
DB00905Bimatoprost2 / 3Completed1
DB00654Latanoprost2 / 3Completed1
DB15071Omidenepag isopropyl2 / 3Completed1
DB00195Betaxolol3Completed2
DB00905Bimatoprost3Completed2
DB00905Bimatoprost3Not Yet Recruiting1
DB00905Bimatoprost3Recruiting2
DB00484Brimonidine3Completed12
DB00484Brimonidine3Not Yet Recruiting1
DB00484Brimonidine3Recruiting1
DB01194Brinzolamide3Completed9
DB01194Brinzolamide3Terminated2
DB00869Dorzolamide3Completed6
DB00869Dorzolamide3Terminated1
DB00654Latanoprost3Completed24
DB00654Latanoprost3Not Yet Recruiting1
DB00654Latanoprost3Recruiting2
DB00654Latanoprost3Terminated1
DB00654Latanoprost3Withdrawn2
DB11660Latanoprostene Bunod3Completed3
DB09351Levobetaxolol3Completed1
DB13931Netarsudil3Completed6
DB08819Tafluprost3Completed8
DB00373Timolol3Active Not Recruiting2
DB00373Timolol3Completed38
DB00373Timolol3Not Yet Recruiting1
DB00373Timolol3Terminated2
DB13122Trabodenoson3Completed1
DB00287Travoprost3Completed13
DB00287Travoprost3Recruiting1
DB00287Travoprost3Terminated2
DB00287Travoprost3Withdrawn1
DB00905Bimatoprost4Completed23
DB00905Bimatoprost4Recruiting2
DB00905Bimatoprost4Withdrawn1
DB00484Brimonidine4Completed15
DB00484Brimonidine4Terminated1
DB01194Brinzolamide4Completed13
DB01194Brinzolamide4Terminated1
DB01234Dexamethasone4Completed1
DB00869Dorzolamide4Completed10
DB00869Dorzolamide4Terminated1
DB00588Fluticasone propionate4Completed1
DB09462Glycerin4Completed1
DB11075Hypromellose4Completed4
DB00654Latanoprost4Completed25
DB00654Latanoprost4Recruiting2
DB00654Latanoprost4Unknown Status1
DB00654Latanoprost4Withdrawn1
DB00873Loteprednol4Completed1
DB13931Netarsudil4Active Not Recruiting1
DB11077Polyethylene glycol 4004Completed1
DB11060Polyvinyl alcohol4Completed2
DB11061Povidone4Completed1
DB08819Tafluprost4Completed5
DB08819Tafluprost4Recruiting1
DB08819Tafluprost4Withdrawn1
DB00373Timolol4Completed25
DB00373Timolol4Terminated1
DB00373Timolol4Withdrawn1
DB00684Tobramycin4Completed1
DB00287Travoprost4Completed20
DB00287Travoprost4Not Yet Recruiting1
DB00287Travoprost4Terminated2
DB00964ApraclonidineNot AvailableUnknown Status1
DB00905BimatoprostNot AvailableCompleted10
DB00905BimatoprostNot AvailableUnknown Status1
DB00484BrimonidineNot AvailableCompleted4
DB00484BrimonidineNot AvailableNot Yet Recruiting1
DB00484BrimonidineNot AvailableUnknown Status1
DB01194BrinzolamideNot AvailableCompleted1
DB01194BrinzolamideNot AvailableUnknown Status1
DB00869DorzolamideNot AvailableUnknown Status1
DB00869DorzolamideNot AvailableWithdrawn1
DB01050IbuprofenNot AvailableCompleted1
DB00654LatanoprostNot AvailableCompleted4
DB00654LatanoprostNot AvailableNot Yet Recruiting1
DB00654LatanoprostNot AvailableUnknown Status2
DB00873LoteprednolNot AvailableCompleted1
DB01085PilocarpineNot AvailableCompleted1
DB00373TimololNot AvailableCompleted9
DB00373TimololNot AvailableNot Yet Recruiting1
DB00373TimololNot AvailableUnknown Status1
DB00373TimololNot AvailableWithdrawn1
DB00684TobramycinNot AvailableCompleted1
DB00287TravoprostNot AvailableCompleted4
DB00287TravoprostNot AvailableUnknown Status1