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Showing drug card for Calcium Acetate (DB00258)

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Version 2.5
Creation Date 2005-06-13 13:24:05
Update Date 2009-04-16 16:47:34
Primary Accession Number DB00258
Secondary Accession Number
  • APRD00839
Name Calcium Acetate
Drug Type
  • Approved
  • Small Molecule
Description The chemical compound calcium acetate is the calcium salt of acetic acid. An older name is acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. [Wikipedia]
Synonyms
  1. Acetic acid, calcium salt
  2. Brown acetate
  3. Brown acetate of lime
  4. Calcium acetate hydrate
  5. Calcium acetate monohydrate
  6. Calcium diacetate
  7. Gray acetate
  8. Gray acetate of lime
  9. Grey acetate
  10. Lime acetate
  11. Lime pyrolignite
  12. Procalamine
  13. Pyrolignite of lime
  14. Vinegar salts
Brand Names
  1. Calac
  2. Niacet calcium acetate tech
  3. PhosLo
  4. PhosLo Gelcaps
  5. Sorbo-calcian
  6. Sorbo-calcion
  7. Teltozan
Brand Mixtures
  1. Anti Stress (Calcium Acetate + Folic Acid + Magnesium Chloride + Menadione Sodium Bisulfite + Potassium (Potassium Bicarbonate) + Pyridoxine Hydrochloride + Sodium Acetate + Sodium Chloride + Vitamin a + Vitamin B12 + Vitamin C + Vitamin D3 + Vitamin E)
  2. Electrolyte Booster- Soluble Powder (Biotin + Calcium Acetate + Folic Acid + Magnesium Chloride + Menadione Sodium Bisulfite + Potassium Chloride + Sodium Acetate + Sodium Bicarbonate + Sodium Chloride + Sodium Diacetate + Vitamin a (Vitamin a Acetate) + Vitamin B12 + Vitamin B2 (Riboflavin) + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C (Ascorbic Acid) + Vitamin D3 (Cholecalciferol) + Vitamin E (Dl-Alpha Tocopheryl Acetate))
  3. Electrolytes Plus (Calcium Acetate + Calcium D-Pantothenate + Choline Bitartrate + Folic Acid + Magnesium Chloride + Menadione (Menadione Sodium Bisulfite) + Nicotinamide + Potassium Chloride + Sodium Acetate + Sodium Chloride + Sodium Diacetate + Vitamin a Acetate + Vitamin B12 + Vitamin B2 + Vitamin D3 + Vitamin E)
  4. Electrovite (Calcium Acetate + Calcium Chloride + Folic Acid + Magnesium Acetate + Menadione Sodium Bisulfite + Potassium Chloride + Sodium Acetate + Sodium Chloride + Sodium Diacetate + Vitamin a + Vitamin B12 + Vitamin B6 + Vitamin C + Vitamin D3 + Vitamin E)
  5. Hyperlyte (Multi-Electrolyte Concentrate) (Calcium Acetate + Magnesium Acetate + Potassium Acetate + Potassium Chloride + Sodium Acetate + Sodium Gluconate)
  6. Jugelect Tab (Calcium Acetate + Calcium Citrate + Magnesium Acetate + Magnesium Citrate + Potassium Chloride + Sodium Chloride)
  7. Lypholyte - Liq Iv (Calcium Acetate + Magnesium Acetate + Potassium Acetate + Potassium Chloride + Sodium Acetate + Sodium Gluconate)
  8. Lypholyte Multi-Electrolyte Conc Inj (Calcium Acetate + Magnesium Acetate + Potassium Acetate + Potassium Chloride + Sodium Acetate + Sodium Gluconate)
  9. Medi-Kool Pak (Aluminum Sulfate + Arnica + Boric Acid + Calcium Acetate + Camphor + Menthol + Methyl Salicylate + Tannic Acid)
  10. Mineralytes Plus (Calcium Acetate + Calcium D-Pantothenate + Choline Bitartrate + Dl-Alpha Tocopheryl Acetate + Folic Acid + Magnesium Chloride + Menadione (Menadione Sodium Bisulfite) + Nicotinamide + Potassium Chloride + Sodium Acetate + Sodium Chloride + Sodium Diacetate + Vitamin a Acetate + Vitamin B12 + Vitamin B2 + Vitamin D3)
  11. Parvit Ii (Calcium Acetate + Folic Acid + Magnesium Chloride + Menadione Sodium Bisulfite (Vitamin K3) + Potassium (Potassium Bicarbonate) + Sodium (Sodium Acetate, Sodium Diacetate, Sodium Chloride) + Vitamin a + Vitamin B12 + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C (Vitamin C) + Vitamin D3 + Vitamin E)
  12. Renodoron - Tablet (Calcium Acetate + Silicon Dioxide)
  13. Super Electrolyte - Pwr Orl (Calcium Acetate + Calcium D-Pantothenate + Choline Bitartrate + Folic Acid + Magnesium Chloride + Menadione (Menadione Sodium Bisulfite) + Nicotinamide + Potassium Chloride + Sodium Acetate + Sodium Chloride + Sodium Diacetate + Vitamin a (Vitamin a Acetate) + Vitamin B12 + Vitamin B2 (Riboflavin) + Vitamin D3 (Cholecalciferol) + Vitamin E (Dl-Alpha Tocopheryl Acetate))
  14. Thc Complex #19 (Aconite + Antimony Trisulfide + Arnica Montana + Beechwood Creosote + Belladonna + Calcium Acetate + Calcium Fluoride + Calcium Phosphate (Tribasic) + Citrullus Colocynthis + Coffee + Delphinium Staphisagria + Ferrum Phosphoricum + German Chamomile + Magnesium Phosphate Dibasic + Plantago Major + Podophyllum + Silicon Dioxide)
  15. Thc Complex #66 (Aconite + Barium Carbonate + Belladonna + Bryonia + Calcium Acetate + Oyster Shells + Phytolacca Decandra + Poison Ivy + Sulfur)
  16. Tym-Plex (Calcium Acetate + Calcium Sulfide Crude + Echinacea Angustifolia + Phosphoric Acid + Phosphorus)
  17. Vitadol Plus Soluble Powder (Calcium Acetate + Folic Acid + Magnesium Chloride + Menadione Sodium Bisulfite + Potassium Bicarbonate + Sodium Acetate + Sodium Chloride + Sodium Diacetate + Vitamin a + Vitamin B12 + Vitamin B6 + Vitamin C + Vitamin D3 + Vitamin E)
Chemical IUPAC Name calcium diacetate
Chemical Formula C4H6CaO4
Chemical Structure Structure
CAS Registry Number 62-54-4
InChI Identifier InChI=1/2C2H4O2.Ca/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2/f2C2H3O2.Ca/q2*-1;m
InChI Key VSGNNIFQASZAOI-BGXWZCFKCS
KEGG Drug D00931 Link Image
KEGG Compound Not Available
PubChem Compound 6116 Link Image
PubChem Substance 7847994 Link Image
ChEBI ID Not Available
PharmGKB ID PA448724 Link Image
HET ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 01982591 Link Image
RxList Link Not Available
PDRhealth Link Not Available
Wikipedia Link http://en.wikipedia.org/wiki/Calcium_Acetate Link Image
FDA Label
Material Safety Data Sheet (MSDS)
Synthesis Reference Not Available
Average Molecular Weight 158.1660
Monoisotopic Molecular Weight 157.9892
State Solid
Melting Point > 160 oC
Experimental Water Solubility Not Available Source: PhysProp
Predicted Water Solubility 1.47e+02 mg/mL Calculated using ALOGPS
Experimental LogP/Hydrophobicity Not Available Source: PhysProp
Predicted LogP 0.24 Calculated using ALOGPS
Experimental LogS Not Available
Predicted LogS -0.03 Calculated using ALOGPS
Experimental Caco2 Permeability Not Available
pKa/Isoelectric Point Not Available
Mass Spectrum Not Available
MOL File Show Link Image | Download Link Image
SDF File Show Link Image | Download Link Image
PDB File Show Link Image | Download Link Image
2D Structure
3D Structure
Experimental PDB ID Not Available
Isomeric SMILES [Ca++].CC([O-])=O.CC([O-])=O
Canonical SMILES [Ca++].CC([O-])=O.CC([O-])=O
Drug Category
  • Antihyperphosphatemics
  • Chelating Agents
ATC Codes
AHFS Codes
  • 40:18.19
  • 92:02.00*
Indication Used to treat hyperphosphatemia (too much phosphate in the blood) in patients with kidney disease.
Pharmacology Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification. The mechanism by which phosphate retention leads to hyperparathyroidism is not clearly delineated. Therapeutic efforts directed toward the control of hyperphosphatemia include reduction in the dietary intake of phosphate, inhibition of absorption of phosphate in the intestine with phosphate binders, and removal of phosphate from the body by more efficient methods of dialysis. The rate of removal of phosphate by dietary manipulation or by dialysis is insufficient. Dialysis patients absorb 40% to 80% of dietary phosphorus. Therefore, the fraction of dietary phosphate absorbed from the diet needs to be reduced by using phosphate binders in most renal failure patients on maintenance dialysis. Calcium acetate when taken with meals combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces. Maintenance of serum phosphorus below 6.0 mg/dl is generally considered as a clinically acceptable outcome of treatment with phosphate binders. Calcium acetate is highly soluble at neutral pH, making the calcium readily available for binding to phosphate in the proximal small intestine.
Mechanism of Action Calcium acetate works by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed.
Absorption 40% is absorbed in the fasting state and approximately 30% is absorbed in the nonfasting state following oral administration.
Toxicity Oral, rat: LD50 = 4280 mg/kg. Symptoms of overdose include mild hypercalcemia (constipation; loss of appetite; nausea and vomiting), and severe hypercalcemia (confusion; full or partial loss of consciousness; incoherent speech).
Protein Binding Not Available
Biotransformation Not Available
Half Life Not Available
Dosage Forms
Form Route
Liquid Oral
Solution / drops Oral
Tablet Oral
Patient Information Not Available
Contraindications Show Link Image
Interactions Show Link Image
Drug Interactions Not Available
Food Interactions Not Available
Pathways Not Available
General References
  1. Drugs.com Link Image
  2. Wikipedia Link Image
Organisms Affected
  • Humans and other mammals

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