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Identification
Name Potassium
Accession Number DB01345
Type small molecule
Groups experimental
Description

Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion pumps in the cell membrane. The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential—a “spike” of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function. Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity.
Structure Thumb
Synonyms Not Available
Brand names Not Available
Brand name mixtures Not Available
Categories Not Available
CAS number Not Available
Weight Not Available
Chemical Formula Not Available
InChI Key Not Available
InChI Not Available
IUPAC Name Not Available
SMILES Not Available
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Not Available
Pharmacodynamics Not Available
Mechanism of action Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion pumps in the cell membrane. The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential—a "spike" of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function. Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity.
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers
Dosage forms
Form Route Strength
Aerosol Oral
Capsule Oral
Capsule, extended release Oral
Elixir Oral
Liquid Intravenous
Liquid Oral
Liquid Sublingual
Powder Oral
Powder, for solution Oral
Solution Intravenous
Solution Oral
Solution / drops Oral
Tablet Oral
Tablet, extended release Oral
Prices Not Available
Patents Not Available
Properties
State solid
Melting point Not Available
Experimental Properties Not Available
Predicted Properties Not Available
References
Synthesis Reference Not Available
General Reference Not Available
External Links
Resource Link
ChEBI 26216 Link_out
ChEMBL 26216 Link_out
Drug Product Database 0 Link_out
Wikipedia http://en.wikipedia.org/wiki/Potassium Link_out
ATC Codes
  • V03AB21
  • B05XA01
  • A12BA30
  • P03AA02
  • B05XA06
  • B05XA17
  • C03DA02
  • B05XA15
  • S01XA04
  • N05BA05
  • A12BA02
  • A12BA01
  • V03AB18
  • A12BA03
  • A12BA04
  • D08AX06
  • H03BC01
  • A12BA05
  • N02BA12
  • R05CA02
AHFS Codes
  • 88:29.00*
  • 92:00.00
  • 92:02.00*
  • 84:92.00
  • 68:36.08
  • 40:12.00
  • 40:28.92
  • 40:34.00*
PDB Entries Not Available
FDA label show (632 KB)
MSDS show (72.2 KB)
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Targets

1. Sodium/potassium-transporting ATPase alpha-1 chain

Pharmacological action: unknown

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients

Organism class: human
UniProt ID: P05023 Link_out
Gene: ATP1A1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Silva E, Gomes P, Soares-da-Silva P: Overexpression of Na()/K ()-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing. J Membr Biol. 2006;212(3):163-75. Epub 2007 Feb 28. Pubmed
  2. Li C, Geering K, Horisberger JD: The third sodium binding site of Na,K-ATPase is functionally linked to acidic pH-activated inward current. J Membr Biol. 2006;213(1):1-9. Epub 2007 Mar 8. Pubmed
  3. Stanely Mainzen Prince P, Karthick M: Preventive effect of rutin on lipids, lipoproteins, and ATPases in normal and isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol. 2007;21(1):1-6. Pubmed
  4. Simon WA, Herrmann M, Klein T, Shin JM, Huber R, Senn-Bilfinger J, Postius S: Soraprazan: setting new standards in inhibition of gastric acid secretion. J Pharmacol Exp Ther. 2007 Jun;321(3):866-74. Epub 2007 Mar 16. Pubmed
  5. Iannello S, Milazzo P, Belfiore F: Animal and human tissue Na,K-ATPase in normal and insulin-resistant states: regulation, behaviour and interpretative hypothesis on NEFA effects. Obes Rev. 2007 May;8(3):231-51. Pubmed
Comments
Drug created on June 30, 2007 12:13 / Updated on April 19, 2011 15:10

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government. This project is also supported in part by GenomeQuest, Inc., an enterprise genomic information company serving the life science community.