DrugBank: Formic Acid (DB01942)

targets (51) transporters (1)

Identification

Name

Formic Acid

Accession Number

DB01942 (EXPT01461)

Type

small molecule

Groups

experimental

Description

Formic acid (systematically called methanoic acid) is the simplest carboxylic acid. It is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and ant stings. The principal use of formic acid is as a preservative and antibacterial agent in livestock feed. [Wikipedia]

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

Aminic acid
Formate
Formylic acid
Hydrogen carboxylic acid
Methanoic acid

Salts

Not Available

Brand names

Not Available

Brand mixtures

Not Available

Categories

Antibacterial Agents

CAS number

64-18-6

Weight

Average: 46.0254
Monoisotopic: 46.005479308

Chemical Formula

CH₂O₂

InChI Key

InChIKey=BDAGIHXWWSANSR-UHFFFAOYSA-N

InChI

InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)

Plain Text

IUPAC Name

formic acid

SMILES

OC=O

Plain Text

Mass Spec

show (7.52 KB)

Taxonomy

Kingdom

Not Available

Classes

Not Available

Substructures

Not Available

Pharmacology

Indication

Not Available

Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Formic acid is readily metabolized and eliminated by the body.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half life

Not Available

Clearance

Not Available

Toxicity

ORAL (LD₅₀): Acute: 700 mg/kg [Mouse]. 1100 mg/kg [Rat]. 4000 mg/kg [Dog].

Affected organisms

Not Available

Pathways

Not Available

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage forms

Not Available

Prices

Not Available

Patents

Not Available

Properties

State

liquid

Experimental Properties

Property	Value	Source
melting point	8.3 °C	PhysProp
boiling point	101 °C	PhysProp
water solubility	1E+006 mg/L (at 25 °C)	RIDDICK,JA ET AL. (1986)
logP	-0.54	HANSCH,C ET AL. (1995)
pKa	3.75 (at 25 °C)	RIDDICK,JA ET AL. (1986)

Predicted Properties

Property	Value	Source
water solubility	4.77e+02 g/l	ALOGPS
logP	-0.47	ALOGPS
logP	-0.27	ChemAxon
logS	1.02	ALOGPS
pKa (strongest acidic)	4.27	ChemAxon
physiological charge	-1	ChemAxon
hydrogen acceptor count	2	ChemAxon
hydrogen donor count	1	ChemAxon
polar surface area	37.3	ChemAxon
rotatable bond count	0	ChemAxon
refractivity	8.15	ChemAxon
polarizability	3.37	ChemAxon

References

Synthesis Reference

Not Available

General Reference

Not Available

External Links

Resource	Link
KEGG Compound	C00058
PubChem Compound	284
PubChem Substance	46508355
ChemSpider	278
ChEBI	30751
ChEMBL	30751
PharmGKB	PA449705
HET	FMT
Wikipedia	http://en.wikipedia.org/wiki/Formic_Acid

ATC Codes

Not Available

AHFS Codes

Not Available

PDB Entries

1B93

FDA label

Not Available

MSDS

show (78.4 KB)

Interactions

Drug Interactions

Not Available

Food Interactions

Not Available

Targets
1. Heme oxygenase 1 Pharmacological action: unknown Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed Organism class: human UniProt ID: P09601 Gene: HMOX1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 2. Ribonuclease pancreatic Pharmacological action: unknown Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA Organism class: human UniProt ID: P07998 Gene: RNASE1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 3. Dihydroorotate dehydrogenase Pharmacological action: unknown (S)-dihydroorotate + O(2) = orotate + H(2)O(2) Organism class: bacterial UniProt ID: P0A7E1 Gene: pyrD Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 4. (S)-2-haloacid dehalogenase Pharmacological action: unknown Catalyzes the hydrolytic dehalogenation of small L-2- haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids. Active with 2-halogenated carboxylic acids and converts only the L-isomer of 2-chloropropionic acid with inversion of configuration to produce D-lactate Organism class: bacterial UniProt ID: Q60099 Gene: dhlB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 5. Beta-lactamase OXA-2 Pharmacological action: unknown This is an oxacillin-hydrolyzing beta-lactamase Organism class: bacterial UniProt ID: P0A1V8 Gene: bla Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 6. Catalase Pharmacological action: unknown Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide Organism class: bacterial UniProt ID: P42321 Gene: katA Protein Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 7. Signal recognition particle protein Pharmacological action: unknown Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes Organism class: bacterial UniProt ID: O07347 Gene: ffh Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 8. Streptavidin Pharmacological action: unknown The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin) Organism class: bacterial UniProt ID: P22629 Protein Sequence: FASTA Gene Sequence: FASTA References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 9. Methylglyoxal synthase Pharmacological action: unknown Glycerone phosphate = methylglyoxal + phosphate Organism class: bacterial UniProt ID: P0A733 Gene: mgsA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 10. C-terminal-binding protein 1 Pharmacological action: unknown Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co- repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity Organism class: human UniProt ID: Q13363 Gene: CTBP1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 11. 6-phosphogluconolactonase Pharmacological action: unknown Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate Organism class: bacterial UniProt ID: Q9X0N8 Gene: pgl Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 12. Citrate lyase beta subunit-like protein Pharmacological action: unknown May play a role in fatty acid biosynthesis (Potential) Organism class: bacterial UniProt ID: O06162 Gene: citE Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 13. Peripheral plasma membrane protein CASK Pharmacological action: unknown Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1 Organism class: human UniProt ID: O14936 Gene: CASK Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 14. Guanylate kinase Pharmacological action: unknown Essential for recycling GMP and indirectly, cGMP (By similarity) Organism class: bacterial UniProt ID: P0A5I4 Gene: gmk Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 15. Probable butyrate kinase 2 Pharmacological action: unknown ATP + butanoate = ADP + butanoyl phosphate Organism class: bacterial UniProt ID: Q9X278 Gene: buk2 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 16. AIG2-like domain-containing protein 1 Pharmacological action: unknown Organism class: human UniProt ID: Q9BVM4 Gene: A2LD1 SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 17. Parvalbumin alpha Pharmacological action: unknown Organism class: human UniProt ID: P20472 Gene: PVALB SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 18. Acylphosphatase-2 Pharmacological action: unknown Organism class: human UniProt ID: P14621 Gene: ACYP2 SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 19. Hypothetical protein Pharmacological action: unknown Organism class: bacterial UniProt ID: Q81C15 Gene: BC_2969 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 20. Arginine N-succinyltransferase subunit alpha Pharmacological action: unknown Catalyzes the transfer of succinyl-CoA to arginine to produce 2-N-succinylarginine. Also acts on L-ornithine Organism class: bacterial UniProt ID: P80357 Gene: astA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 21. Mannose-6-phosphate isomerase Pharmacological action: unknown D-mannose 6-phosphate = D-fructose 6- phosphate Organism class: bacterial UniProt ID: P39841 Gene: yvyI Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 22. Nitric-oxide synthase, brain Pharmacological action: unknown Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter Organism class: human UniProt ID: P29475 Gene: NOS1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 23. Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9X0V0 Gene: TM_1223 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 24. Putative hydrolase ycdX Pharmacological action: unknown Organism class: bacterial UniProt ID: P75914 Gene: ycdX Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 25. Phenazine biosynthesis protein PhzD Pharmacological action: unknown Organism class: bacterial UniProt ID: Q7DC80 Gene: phzD1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 26. Oxalate decarboxylase oxdC Pharmacological action: unknown Converts oxalate to formate and CO(2) in an O(2)- dependent reaction. Can also catalyze minor side reactions:oxalate oxidation to produce H(2)O(2), and oxalate-dependent, H(2)O(2)-independent dye oxidations Organism class: bacterial UniProt ID: O34714 Gene: oxdC Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 27. Putative ketoacyl reductase Pharmacological action: unknown Organism class: bacterial UniProt ID: P16544 Gene: actIII Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 28. Gephyrin Pharmacological action: unknown Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Involved in molybdenum cofactor biosynthesis. Required for molybdenum transfer to molybdopterin. In a first step, copper-molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released (By similarity) Organism class: human UniProt ID: Q9NQX3 Gene: GPHN Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed 29. Glyoxalase family protein Pharmacological action: unknown Organism class: bacterial UniProt ID: Q81F54 Gene: BC_1747 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 30. Cytohesin-2 Pharmacological action: unknown Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF through replacement of GDP with GTP Organism class: human UniProt ID: Q99418 Gene: CYTH2 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 31. Glutaconyl-CoA decarboxylase subunit alpha Pharmacological action: unknown Decarboxylase subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD) Organism class: bacterial UniProt ID: Q06700 Gene: gcdA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 32. Transcriptional regulator, IclR family Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9WXS0 Gene: TM_0065 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 33. Hypothetical protein VC1899 Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9KQU9 Gene: VC_1899 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 34. Catalase Pharmacological action: unknown Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide Organism class: bacterial UniProt ID: P77872 Gene: katA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 35. Hypothetical protein Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9X0F9 Gene: TM_1070 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 36. Glutathione S-transferase Pharmacological action: unknown Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin) Organism class: parasitic UniProt ID: Q8MU52 Gene: GST Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 37. Hypoxanthine-guanine phosphoribosyltransferase, putative Pharmacological action: unknown GMP + diphosphate = guanine + 5-phospho-alpha- D-ribose 1-diphosphate Organism class: parasitic UniProt ID: Q27796 Gene: HGPRTase Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 38. Glutaminase 1 Pharmacological action: unknown L-glutamine + H(2)O = L-glutamate + NH(3) Organism class: bacterial UniProt ID: O31465 Gene: glsA1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 39. Glutaminase 1 Pharmacological action: unknown L-glutamine + H(2)O = L-glutamate + NH(3) Organism class: bacterial UniProt ID: P77454 Gene: glsA1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 40. Molybdopterin-converting factor subunit 2 Pharmacological action: unknown Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group Organism class: bacterial UniProt ID: P30749 Gene: moaE Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 41. Aminotransferase, putative Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9X0L5 Gene: TM_1131 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 42. Iron binding protein FbpA Pharmacological action: unknown Organism class: bacterial UniProt ID: Q9Z4N6 Gene: fbpA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 43. Gyrase B Pharmacological action: unknown DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Organism class: bacterial UniProt ID: Q9LCX5 Gene: gyrB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report 44. Protein ygbM Pharmacological action: unknown Organism class: bacterial UniProt ID: Q46891 Gene: ygbM Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 45. Delta-aminolevulinic acid dehydratase Pharmacological action: unknown 2 5-aminolevulinate = porphobilinogen + 2 H(2)O Organism class: bacterial UniProt ID: Q59643 Gene: hemB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 46. 3-phosphoshikimate 1-carboxyvinyltransferase Pharmacological action: unknown Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate Organism class: bacterial UniProt ID: P0A6D3 Gene: aroA Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 47. Subtilisin Carlsberg Pharmacological action: unknown Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides Organism class: bacterial UniProt ID: P00780 Gene: apr Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 48. Fibroblast growth factor 1 Pharmacological action: unknown The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors Organism class: human UniProt ID: P05230 Gene: FGF1 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 49. Peptide deformylase Pharmacological action: unknown Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions Organism class: bacterial UniProt ID: P0A6K3 Gene: def Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 50. Para-aminobenzoate synthase component 1 Pharmacological action: unknown Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine Organism class: bacterial UniProt ID: P05041 Gene: pabB Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed 51. Carbonic anhydrase 2 Pharmacological action: unknown Reversible hydration of carbon dioxide Organism class: human UniProt ID: P00918 Gene: CA2 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Targets

1. Heme oxygenase 1

Pharmacological action: unknown

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed

Organism class: human
UniProt ID: P09601 Link_out

Gene: HMOX1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

2. Ribonuclease pancreatic

Pharmacological action: unknown

Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA

Organism class: human
UniProt ID: P07998 Link_out

Gene: RNASE1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

3. Dihydroorotate dehydrogenase

Pharmacological action: unknown

(S)-dihydroorotate + O(2) = orotate + H(2)O(2)

Organism class: bacterial
UniProt ID: P0A7E1 Link_out

Gene: pyrD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

4. (S)-2-haloacid dehalogenase

Pharmacological action: unknown

Catalyzes the hydrolytic dehalogenation of small L-2- haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids. Active with 2-halogenated carboxylic acids and converts only the L-isomer of 2-chloropropionic acid with inversion of configuration to produce D-lactate

Organism class: bacterial
UniProt ID: Q60099 Link_out

Gene: dhlB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

5. Beta-lactamase OXA-2

Pharmacological action: unknown

This is an oxacillin-hydrolyzing beta-lactamase

Organism class: bacterial
UniProt ID: P0A1V8 Link_out

Gene: bla
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

6. Catalase

Pharmacological action: unknown

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide

Organism class: bacterial
UniProt ID: P42321 Link_out

Gene: katA
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

7. Signal recognition particle protein

Pharmacological action: unknown

Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes

Organism class: bacterial
UniProt ID: O07347 Link_out

Gene: ffh
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

8. Streptavidin

Pharmacological action: unknown

The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin)

Organism class: bacterial
UniProt ID: P22629 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

9. Methylglyoxal synthase

Pharmacological action: unknown

Glycerone phosphate = methylglyoxal + phosphate

Organism class: bacterial
UniProt ID: P0A733 Link_out

Gene: mgsA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

10. C-terminal-binding protein 1

Pharmacological action: unknown

Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co- repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity

Organism class: human
UniProt ID: Q13363 Link_out

Gene: CTBP1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

11. 6-phosphogluconolactonase

Pharmacological action: unknown

Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate

Organism class: bacterial
UniProt ID: Q9X0N8 Link_out

Gene: pgl
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

12. Citrate lyase beta subunit-like protein

Pharmacological action: unknown

May play a role in fatty acid biosynthesis (Potential)

Organism class: bacterial
UniProt ID: O06162 Link_out

Gene: citE
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

13. Peripheral plasma membrane protein CASK

Pharmacological action: unknown

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1

Organism class: human
UniProt ID: O14936 Link_out

Gene: CASK
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

14. Guanylate kinase

Pharmacological action: unknown

Essential for recycling GMP and indirectly, cGMP (By similarity)

Organism class: bacterial
UniProt ID: P0A5I4 Link_out

Gene: gmk
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

15. Probable butyrate kinase 2

Pharmacological action: unknown

ATP + butanoate = ADP + butanoyl phosphate

Organism class: bacterial
UniProt ID: Q9X278 Link_out

Gene: buk2
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

16. AIG2-like domain-containing protein 1

Pharmacological action: unknown
Organism class: human
UniProt ID: Q9BVM4 Link_out

Gene: A2LD1
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

17. Parvalbumin alpha

Pharmacological action: unknown
Organism class: human
UniProt ID: P20472 Link_out

Gene: PVALB
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

18. Acylphosphatase-2

Pharmacological action: unknown
Organism class: human
UniProt ID: P14621 Link_out

Gene: ACYP2
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

19. Hypothetical protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q81C15 Link_out

Gene: BC_2969
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

20. Arginine N-succinyltransferase subunit alpha

Pharmacological action: unknown

Catalyzes the transfer of succinyl-CoA to arginine to produce 2-N-succinylarginine. Also acts on L-ornithine

Organism class: bacterial
UniProt ID: P80357 Link_out

Gene: astA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

21. Mannose-6-phosphate isomerase

Pharmacological action: unknown

D-mannose 6-phosphate = D-fructose 6- phosphate

Organism class: bacterial
UniProt ID: P39841 Link_out

Gene: yvyI
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

22. Nitric-oxide synthase, brain

Pharmacological action: unknown

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter

Organism class: human
UniProt ID: P29475 Link_out

Gene: NOS1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

23. Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9X0V0 Link_out

Gene: TM_1223
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

24. Putative hydrolase ycdX

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: P75914 Link_out

Gene: ycdX
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

25. Phenazine biosynthesis protein PhzD

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q7DC80 Link_out

Gene: phzD1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

26. Oxalate decarboxylase oxdC

Pharmacological action: unknown

Converts oxalate to formate and CO(2) in an O(2)- dependent reaction. Can also catalyze minor side reactions:oxalate oxidation to produce H(2)O(2), and oxalate-dependent, H(2)O(2)-independent dye oxidations

Organism class: bacterial
UniProt ID: O34714 Link_out

Gene: oxdC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

27. Putative ketoacyl reductase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: P16544 Link_out

Gene: actIII
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

28. Gephyrin

Pharmacological action: unknown

Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Involved in molybdenum cofactor biosynthesis. Required for molybdenum transfer to molybdopterin. In a first step, copper-molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released (By similarity)

Organism class: human
UniProt ID: Q9NQX3 Link_out

Gene: GPHN
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

29. Glyoxalase family protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q81F54 Link_out

Gene: BC_1747
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

30. Cytohesin-2

Pharmacological action: unknown

Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF through replacement of GDP with GTP

Organism class: human
UniProt ID: Q99418 Link_out

Gene: CYTH2
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

31. Glutaconyl-CoA decarboxylase subunit alpha

Pharmacological action: unknown

Decarboxylase subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD)

Organism class: bacterial
UniProt ID: Q06700 Link_out

Gene: gcdA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

32. Transcriptional regulator, IclR family

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9WXS0 Link_out

Gene: TM_0065
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

33. Hypothetical protein VC1899

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9KQU9 Link_out

Gene: VC_1899
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

34. Catalase

Pharmacological action: unknown

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide

Organism class: bacterial
UniProt ID: P77872 Link_out

Gene: katA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

35. Hypothetical protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9X0F9 Link_out

Gene: TM_1070
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

36. Glutathione S-transferase

Pharmacological action: unknown

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin)

Organism class: parasitic
UniProt ID: Q8MU52 Link_out

Gene: GST
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

37. Hypoxanthine-guanine phosphoribosyltransferase, putative

Pharmacological action: unknown

GMP + diphosphate = guanine + 5-phospho-alpha- D-ribose 1-diphosphate

Organism class: parasitic
UniProt ID: Q27796 Link_out

Gene: HGPRTase
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

38. Glutaminase 1

Pharmacological action: unknown

L-glutamine + H(2)O = L-glutamate + NH(3)

Organism class: bacterial
UniProt ID: O31465 Link_out

Gene: glsA1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

39. Glutaminase 1

Pharmacological action: unknown

L-glutamine + H(2)O = L-glutamate + NH(3)

Organism class: bacterial
UniProt ID: P77454 Link_out

Gene: glsA1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

40. Molybdopterin-converting factor subunit 2

Pharmacological action: unknown

Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group

Organism class: bacterial
UniProt ID: P30749 Link_out

Gene: moaE
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

41. Aminotransferase, putative

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9X0L5 Link_out

Gene: TM_1131
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

42. Iron binding protein FbpA

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9Z4N6 Link_out

Gene: fbpA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

43. Gyrase B

Pharmacological action: unknown

DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)

Organism class: bacterial
UniProt ID: Q9LCX5 Link_out

Gene: gyrB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

44. Protein ygbM

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q46891 Link_out

Gene: ygbM
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

45. Delta-aminolevulinic acid dehydratase

Pharmacological action: unknown

2 5-aminolevulinate = porphobilinogen + 2 H(2)O

Organism class: bacterial
UniProt ID: Q59643 Link_out

Gene: hemB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

46. 3-phosphoshikimate 1-carboxyvinyltransferase

Pharmacological action: unknown

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate

Organism class: bacterial
UniProt ID: P0A6D3 Link_out

Gene: aroA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

47. Subtilisin Carlsberg

Pharmacological action: unknown

Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides

Organism class: bacterial
UniProt ID: P00780 Link_out

Gene: apr
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

48. Fibroblast growth factor 1

Pharmacological action: unknown

The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors

Organism class: human
UniProt ID: P05230 Link_out

Gene: FGF1 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

49. Peptide deformylase

Pharmacological action: unknown

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions

Organism class: bacterial
UniProt ID: P0A6K3 Link_out

Gene: def
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

50. Para-aminobenzoate synthase component 1

Pharmacological action: unknown

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine

Organism class: bacterial
UniProt ID: P05041 Link_out

Gene: pabB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

51. Carbonic anhydrase 2

Pharmacological action: unknown

Reversible hydration of carbon dioxide

Organism class: human
UniProt ID: P00918 Link_out

Gene: CA2

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

Transporters
1. Monocarboxylate transporter 4 Actions: substrate Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate UniProt ID: O15427 Gene: SLC16A3 Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. Pubmed

Transporters

1. Monocarboxylate transporter 4

Actions: substrate

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate

UniProt ID: O15427 Link_out

Gene: SLC16A3 Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. Pubmed

Comments

Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:20