Niacinamide ascorbate
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Identification
- Generic Name
- Niacinamide ascorbate
- DrugBank Accession Number
- DB14486
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved, Nutraceutical
- Structure
- Weight
- Average: 298.251
Monoisotopic: 298.080100799 - Chemical Formula
- C12H14N2O7
- Synonyms
- Ascorbic acid nicotinamide complex
- Niacinamide ascorbate
- Nicotinamide-ascorbic acid complex
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAmphetamine The serum concentration of Amphetamine can be decreased when it is combined with Niacinamide ascorbate. Benzphetamine The serum concentration of Benzphetamine can be decreased when it is combined with Niacinamide ascorbate. Bleomycin The therapeutic efficacy of Bleomycin can be decreased when used in combination with Niacinamide ascorbate. Bortezomib The therapeutic efficacy of Bortezomib can be decreased when used in combination with Niacinamide ascorbate. Chlorpropamide Niacinamide ascorbate may decrease the excretion rate of Chlorpropamide which could result in a higher serum level. - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Active Moieties
Name Kind UNII CAS InChI Key Ascorbic acid complex PQ6CK8PD0R 50-81-7 CIWBSHSKHKDKBQ-JLAZNSOCSA-N Nicotinamide complex 25X51I8RD4 98-92-0 DFPAKSUCGFBDDF-UHFFFAOYSA-N - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Daily Balance Tab Niacinamide ascorbate (60 mg / tab) + Niacinamide ascorbate (20 mg / tab) + Beta carotene (1000 unit / tab) + Cyanocobalamin (6 mcg / tab) + D-alpha-Tocopherol acetate (30 unit / tab) + Folic acid (.4 mg / tab) + Calcium pantothenate (10 mg / tab) + Pyridoxine hydrochloride (2 mg / tab) + Riboflavin (1.7 mg / tab) + Thiamine mononitrate (1.5 mg / tab) + Vitamin A acetate (4000 unit / tab) + Vitamin D (400 unit / tab) Tablet Oral Pharmavite 1995-12-31 1998-09-08 Canada Daily Balance Tab Niacinamide ascorbate (60 mg / tab) + Niacinamide ascorbate (20 mg / tab) + Beta carotene (1000 unit / tab) + Cyanocobalamin (6 mcg / tab) + D-alpha-Tocopherol acetate (30 unit / tab) + Folic acid (.4 mg / tab) + Calcium pantothenate (10 mg / tab) + Pyridoxine hydrochloride (2 mg / tab) + Riboflavin (1.7 mg / tab) + Thiamine mononitrate (1.5 mg / tab) + Vitamin A acetate (4000 unit / tab) + Vitamin D (400 unit / tab) Tablet Oral Pharmavite 1995-12-31 1998-09-08 Canada Multiple Vitamins With Iron Tablets Niacinamide ascorbate (60 mg / tab) + Cyanocobalamin (6 mcg / tab) + DL-alpha tocopheryl acetate (30 unit / tab) + Ferrous fumarate (4 mg / tab) + Folic acid (.4 mg / tab) + Nicotinamide (20 mg / tab) + Calcium pantothenate (10 mg / tab) + Pyridoxine hydrochloride (2 mg / tab) + Riboflavin (1.7 mg / tab) + Thiamine mononitrate (1.5 mg / tab) + Vitamin A acetate (5000 unit / tab) + Vitamin D (400 unit / tab) Tablet Oral Pharmavite 1995-12-31 2000-08-24 Canada Nutrifer Plus Tablets Niacinamide ascorbate (25 mg) + Niacinamide ascorbate (150 mg) + Calcium (125 mg) + Cholecalciferol (400 unit) + Copper (1 mg) + Cyanocobalamin (5 mcg) + Ferrous fumarate (60 mg) + Folic acid (1 mg) + Riboflavin (2 mg) + Thiamine mononitrate (4.5 mg) + Vitamin A palmitate (5000 unit) Tablet Oral Wyeth Ayerst Canada Inc. 1994-12-31 1999-09-23 Canada Nutrifer Plus Tablets Niacinamide ascorbate (25 mg) + Niacinamide ascorbate (150 mg) + Calcium (125 mg) + Cholecalciferol (400 unit) + Copper (1 mg) + Cyanocobalamin (5 mcg) + Ferrous fumarate (60 mg) + Folic acid (1 mg) + Riboflavin (2 mg) + Thiamine mononitrate (4.5 mg) + Vitamin A palmitate (5000 unit) Tablet Oral Wyeth Ayerst Canada Inc. 1994-12-31 1999-09-23 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Se-Natal Niacinamide ascorbate (120 mg/1) + Calcium carbonate (250 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Docusate sodium (50 mg/1) + Ergocalciferol (400 [iU]/1) + Ferrous fumarate (90 mg/1) + Folic acid (1 mg/1) + Niacin (20 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine mononitrate (3 mg/1) + Vitamin A acetate (4000 [iU]/1) + Zinc oxide (25 ug/1) Tablet Oral Seton Pharmaceuticals 2009-04-16 2011-07-31 US Se-Natal One Niacinamide ascorbate (80 mg/1) + Biotin (30 ug/1) + Calcium carbonate (200 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (2.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Ferrous fumarate (60 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (100 mg/1) + Nicotinamide (17 mg/1) + Pantothenic acid (7 mg/1) + Pyridoxine hydrochloride (4 mg/1) + Riboflavin (1.6 mg/1) + Thiamine hydrochloride (1.5 mg/1) + Vitamin A acetate (4000 [iU]/1) + Zinc oxide (25 mg/1) Tablet Oral Seton Pharmaceuticals 2009-04-16 2011-12-21 US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- JTL8B7TVW7
- CAS number
- 1987-71-9
- InChI Key
- JMORAWFVNMGOKQ-MGMRMFRLSA-N
- InChI
- InChI=1S/C6H6N2O.C6H8O6/c7-6(9)5-2-1-3-8-4-5;7-1-2(8)5-3(9)4(10)6(11)12-5/h1-4H,(H2,7,9);2,5,7-10H,1H2/t;2-,5+/m.0/s1
- IUPAC Name
- (5R)-5-(1,2-dihydroxyethyl)-3,4-dihydroxy-2,5-dihydrofuran-2-one; pyridine-3-carboxamide
- SMILES
- NC(=O)C1=CN=CC=C1.[H]C(O)(CO)[C@@]1([H])OC(=O)C(O)=C1O
References
- General References
- Not Available
- External Links
- ChemSpider
- 18895044
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, film coated Oral Tablet Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 245.0 mg/mL ALOGPS logP -1.6 ALOGPS logP -1.9 Chemaxon logS 0.14 ALOGPS pKa (Strongest Acidic) 4.36 Chemaxon pKa (Strongest Basic) -3 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 107.22 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 37.03 m3·mol-1 Chemaxon Polarizability 15.03 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 135.6934793 predictedDarkChem Lite v0.1.0 [M-H]- 159.36583 predictedDeepCCS 1.0 (2019) [M+H]+ 136.8643793 predictedDarkChem Lite v0.1.0 [M+H]+ 161.7614 predictedDeepCCS 1.0 (2019) [M+Na]+ 135.3103793 predictedDarkChem Lite v0.1.0 [M+Na]+ 168.46751 predictedDeepCCS 1.0 (2019)
Drug created at July 06, 2018 22:30 / Updated at December 01, 2022 11:28