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Displaying drugs 76 - 100 of 15141 in total
Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective in treating Tinea versicolor.
Approved
Investigational
Matched Synonyms: … 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone …
Matched Iupac: … 6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one …
Matched Description: … Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a …
Matched Categories: … Vaginal Creams, Foams, and Jellies ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Approved
Vet approved
Matched Synonyms: … O-methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate ... (5-(propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester …
Matched Iupac: … methyl N-[6-(propylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbamate …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …
Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown...
Approved
Investigational
Matched Synonyms: … ]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid ... (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8- quinolinyl)sulfonyl …
Matched Description: … suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and
Matched Categories: … moxonidine and diuretics …
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Approved
Matched Description: … It has bactericidal activity and is used often as a topical disinfectant. ... A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout ... It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as …
Matched Mixtures name: … Northside Hospital Natural Mothers Bag ... Lord and Berry ... Alcohol and Dextrose …
Matched Categories: … Antiseptics and Disinfectants …
Matched Products: … QUR Eucalyptus Essential Oil Hand Sanitizer ... Hygienex Hand Sanitizer Liquid Sanitizer with Eucalyptus Oil ... Hello hand sanitizer - fresh mint and tea tree oil
Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections , . Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils . The acute sore throat (pharyngitis)...
Approved
Matched Synonyms: … 5-methyl-2-pentylphenol …
Matched Iupac: … 5-methyl-2-pentylphenol …
Matched Description: … Pharyngitis is normally caused by viruses and proves benign and self-limiting. ... symptoms, and are increasingly important in the management of this condition [A32787]. ... antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and
Matched Mixtures name: … BETADINE SORE THROAT LOZENGES MENTHOL & EUCALYPTUS ... STREPSILS HONEY AND LEMON ... STREPSILS SORE THROAT AND BLOCKED NOSE LOZENGE …
A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss.
Approved
Matched Synonyms: … 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone ... 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide ... 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide …
Matched Iupac: … 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide …
Matched Description: … It also tends to lower blood pressure and increase potassium loss. …
Matched Categories: … Genito Urinary System and Sex Hormones ... metolazone and potassium-sparing agents ... Gynecological Antiinfectives and Antiseptics ... Low-Ceiling Diuretics and Potassium-Sparing Agents …
An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the...
Approved
Matched Synonyms: … 1-Methyl-D-lysergic acid butanolamide ... (+)-N-(1-(Hydroxymethyl)propyl)-1-methyl-D-lysergamide ... 1-Methyl-dextro-lysergic acid (+)-1-hydroxy-2-butylamide …
Matched Description: … Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin ... It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has …
Matched Categories: … Ergot Alkaloids and Derivatives …
Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis.[L8240,L8270] It is a racemic mixture, though there is no noted difference in pharmacologic activity between enantiomers, and was first...
Approved
Matched Synonyms: … 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone …
Matched Iupac: … 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one …
Matched Description: … vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis. ... phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and ... racemic mixture, though there is no noted difference in pharmacologic activity between enantiomers, and
Matched Mixtures name: … Azelastine hydrochloride and Fluticasone propionate ... Azelastine Hydrochloride and Fluticasone Propionate ... Azelastine Hydrochloride and Fluticasone Propionate …
Matched Categories: … Decongestants and Antiallergics …
Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food products, and lubricants. It is used in a number of health and beauty products including hair care...
Approved
Matched Description: … Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). ... for children and may serve as less toxic and less resistance-prone alternative to pesticide-containing ... , leave-in conditioner, and de-tangling products. …
Matched Mixtures name: … Hand and Nature Anti Wrinkle Hand Aragon Oil ... Hand and Nature Anti Wrinkle Hand Almond Oil ... Mentholatum Natural Ice Cherry …
Matched Categories: … Basic Ointments and Protectants ... Scabicides and Pediculicides ... Skin and Mucous Membrane Agents ... Scabicides, Insecticides and Repellents ... Antiparasitic Products, Insecticides and Repellents …
Matched Products: … Aveeno Baby Daily Moisture with Coconut Oil and Shea Butter ... Marcs Daily Moisturizing with Soy and Natural Colloidal Oatmeal ... OBERON MOMS CARE OIL
Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved testing...
Approved
Matched Synonyms: … N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino …
Matched Iupac: … N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino …
Matched Description: … where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved testing and ... Approximately 10% of patients with NSCLC have a rapid and clinically effective response to EGFR-TKIs ... [A7927] More specifically, deletions around the LREA motif in exon 19 and exon 21 L858R point mutations …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Ensulizole, also known as 2-phenylbenzimidazole-5-sulfonic acid, is a water-soluble sunscreen agent that absorbs strongly at UV-B wavelengths. It is commonly found in cosmetic products and sunscreen formulas in combination with other UV filter compounds due to its minimal protection against UV-A wavelengths. Due to its water solubility, ensulizole is commonly...
Approved
Matched Description: … It is commonly found in cosmetic products and sunscreen formulas in combination with other UV filter ... Due to its water solubility, ensulizole is commonly used in products formulated to feel light and less ... the maximal approved concentration of ensulizole is 148 mM although concentrations ranging between 74 and
Matched Mixtures name: … NATURAL SUN ECO Oil Clear Sunscreen Cream 50 SPF ... Natural Sun Eco Oil Clear Sun Cream Spf50+ Pa+++ ... THEFACESHOP CC Cushion Natural Beige Oil-Free SPF 50 …
Matched Products: … Dolce and Gabbana The Foundation Perfect Matte Broadspectrum SPF 20 All shades ... Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 820 Creamy Natural ... Covergirl Outlast Stay Fabulous 3in1 Foundation Broad spectrum SPF 20 - 840 Natural Beige …
Colloidal oatmeal is produced by grinding fine granules of oatmeal and boiling it to extract the colloidal material. It contains high concentrations of starches and beta-glucan that exhibits water-absorbing properties. Phenols are also contained in colloidal oatmeal, which possess antioxidant and anti-inflammatory activities, as well as UV-absorbing activity. Colloidal oatmeal...
Approved
Nutraceutical
Matched Description: … skin irritation and itching due to rashes, eczema, poison ivy, oak, sumac, or insect bites. ... Colloidal oatmeal is produced by grinding fine granules of oatmeal and boiling it to extract the colloidal ... It contains high concentrations of starches and beta-glucan that exhibits water-absorbing properties. …
Matched Mixtures name: … Dermavive Shower and Bath Oil ... After Bite Natural
Matched Products: … Babo Sensitive Baby All Natural Healing ... Bite and Sting Soother ... Calming Itch and Irritation …
Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and metabolites, resulting in complex systemic pathologies. Heart...
Approved
Matched Synonyms: … 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile …
Matched Iupac: … 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile …
Matched Description: … and peripheral vasodilation in acute decongested heart failure. ... failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and ... cyclic adenosine monophosphate (cAMP) production, which affects the heart's contractile function and
Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others. . Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike older 1,4-benzodiazepines, clobazam has...
Approved
Illicit
Matched Synonyms: … 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione ... 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine …
Matched Iupac: … 7-chloro-1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione …
Matched Description: … , Frisium, Urbanyl, and others. ... children aged two years and older. ... and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. …
Matched Categories: … Benzodiazepines and benzodiazepine derivatives …
An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Approved
Investigational
Matched Synonyms: … (+)-(2R)-2-(2-(((R)-p-chloro-α-methyl-α-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine ... (+)-(2R)-2-[2-[[(R)-p-chloro-α-methyl-α-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine …
Matched Description: … ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and
Clocortolone is a medium potency corticosteroid that is often used as a topical cream for the relief of inflammatory oand pruritic (itching) arising from steroid-responsive dermatoses of the scalp.
Approved
Matched Synonyms: … 9-chloro-6alpha-Fluoro-11beta,21-dihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dione ... 9-chloro-6alpha-Fluoro-16alpha-methyl-1,4-pregnadiene-11beta,21-diol-3,20-dione …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone...
Approved
Matched Synonyms: … isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Iupac: … 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Description: … of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and
Matched Categories: … Calcium-Regulating Hormones and Agents …
Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the...
Approved
Vet approved
Withdrawn
Matched Synonyms: … (4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl
Matched Iupac: … (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene …
Matched Description: … exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and ... It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane …
Matched Mixtures name: … Bismuth Subcitrate Potassium, Metronidazole and Tetracycline Hydrochloride ... Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline Hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism ... tetracycline and oleandomycin ... Ophthalmological and Otological Preparations ... lansoprazole, tetracycline and metronidazole ... Antiinfectives and Antiseptics for Local Oral Treatment …
Matched Products: … MeaStem First Aid and Antibiotic …
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength...
Approved
Investigational
Matched Synonyms: … (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol ... (5α,6α)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol ... (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol …
Matched Iupac: … (1S,5R,13R,14S,17R)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,15 …
Matched Description: … [A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk ... strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and
Matched Categories: … Natural Opium Alkaloids ... morphine and antispasmodics …
Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced.
Approved
Matched Synonyms: … (E)-3-[2-n-butyl-1-{(4-carboxyphenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid ... (E)-α{[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazole-5-yl]methylene}-2-thiopheneproprionic acid …
Matched Iupac: … 4-({2-butyl-5-[(1E)-2-carboxy-2-[(thiophen-2-yl)methyl]eth-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic …
Matched Description: … By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs …
Matched Categories: … eprosartan and diuretics ... Angiotensin II receptor blockers (ARBs) and diuretics …
Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.
Approved
Matched Synonyms: … 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine ... 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine …
Matched Iupac: … methyl(3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine …
Matched Description: … and other conditions. ... [L11878] It is used in the treatment of major depression and is also used off-label for chronic pain …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Approved
Matched Synonyms: … 11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine ... 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine …
Matched Description: … those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and ... thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release …
An imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.
Approved
Investigational
Matched Synonyms: … Ethyl 3-methyl-2-thioimidazoline-1-carboxylate …
Matched Iupac: … ethyl 3-methyl-2-sulfanylidene-2,3-dihydro-1H-imidazole-1-carboxylate …
Matched Categories: … Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms. Alprazolam's adverse...
Approved
Illicit
Investigational
Matched Synonyms: … 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine …
Matched Iupac: … 12-chloro-3-methyl-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene …
Matched Description: … ketoconazole and itraconazole. ... Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders. ... [L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepines and benzodiazepine derivatives …
Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult patients with gout...
Approved
Matched Synonyms: … 2-(3-cyano-4-isobutoxyphenyl)-4-methyl- 1,3-thiazole-5-carboxylic acid …
Matched Iupac: … 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid …
Matched Description: … granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and ... further deposition of uric acid crystal deposition in bones, joints, tissues, and other organs in the ... that is caused by the accumulation of uric acid crystal in or around a joint, leading to inflammation and
Displaying drugs 76 - 100 of 15141 in total