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Displaying drugs 226 - 250 of 8131 in total

Armodafinil

Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists...
Approved
Investigational
Matched Description: … Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. ... Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated ... (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Lurasidone

Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.
Approved
Investigational
Matched Description: … pending approval for the treatment of bipolar disorder in the United States. ... Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Dapsone

A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of...
Approved
Investigational
Matched Description: … Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of ... It is also used with pyrimethamine in the treatment of malaria. ... A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium …
Matched Categories: … Drugs for Treatment of Lepra …

Emtricitabine

Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults or combined with tenofovir alafenamide for the prevention of HIV-1 infection in high risk adolescents and adults. Emtricitabine is a cytidine analogue. The drug works by inhibiting HIV reverse transcriptase, preventing transcription of...
Approved
Investigational
Matched Description: … Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV ... infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection ... [L9019] The drug works by inhibiting HIV reverse transcriptase, preventing transcription of HIV RNA to …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Sodium citrate

Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing...
Approved
Investigational
Matched Description: … Sodium citrate is the sodium salt of citric acid. ... It has been indicated for the treatment of metabolic acidosis. ... From the medical point of view, it is used as alkalinizing agent. …
Matched Mixtures name: … Reveos Select CPD/AS-5 Red Cell Preservative For Collection Of Blood …

Nortriptyline

Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.
Approved
Matched Description: … Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant ... [L11878] It is used in the treatment of major depression and is also used off-label for chronic pain …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Meperidine

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Approved
Matched Description: … A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including ... postoperative pain and the pain of labor. ... with morphine and are of shorter duration. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Safinamide

Safinamide is for the treatment of parkinson's disease. It was approved in Europe in February 2015, and in the United States on March 21, 2017.
Approved
Investigational
Matched Description: … Safinamide is for the treatment of parkinson's disease. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Cholecalciferol

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are...
Approved
Nutraceutical
Matched Description: … vitamin d and are found in various types of food for daily intake [L5689]. ... Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin ... Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus …
Matched Categories: … Drugs for Treatment of Bone Diseases …

Fluorometholone

A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
Approved
Investigational
Matched Description: … of the eye. ... It has also been used topically in the treatment of various skin disorders. ... A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Hydrochlorothiazide

Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA...
Approved
Vet approved
Matched Description: … [A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting …
Matched Categories: … combinations of sulfonamides …

Caffeine

Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to Theophylline and Theobromine.[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in...
Approved
Matched Description: … life of premature infants. ... Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory ... conditions of the premature newborn, pain relief, and to combat drowsiness. …
Matched Mixtures name: … Acetaminophen, Caffeine, and 8mg Of Codeine Phosphate Tablets ... Acetaminophen, Caffeine and 8 Mg Of Codeine Phosphate Tablets …
Matched Categories: … combinations of xanthines …

Wormwood

Wormwood is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental

Phenylephrine

Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939.
Approved
Matched Description: … [A187370] The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s …
Matched Mixtures name: … Hot Lemon Relief for Symptoms Of Cold and Flu ... Hot Lemon Relief for Symptoms Of Cough and Cold ... Hot Liquid Relief for Symptoms Of Cold and Cough …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Amitriptyline

Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.
Approved
Matched Description: … ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961 ... [A259342] Amitriptyline has been investigated in the treatment of pain-related conditions, attributed …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Mitapivat

Mitapivat is a novel, first-in-class pyruvate kinase activator. It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival of red blood cells. Defects in the pyruvate kinase enzyme in various red blood cells disorders lead to the lack of energy production for red...
Approved
Investigational
Matched Description: … of red blood cells. ... It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival ... Defects in the pyruvate kinase enzyme in various red blood cells disorders lead to the lack of energy …
Matched Categories: … combinations of sulfonamides …

Zidovudine

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator...
Approved
Matched Description: … of nucleic acid chains. ... The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during ... This modification prevents the formation of phosphodiester linkages which are needed for the completion …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Tetracycline

Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the...
Approved
Vet approved
Withdrawn
Matched Description: … [L43942] Other formulations of tetracycline continue to be used. ... Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria ... The FDA withdrew its approval for the use of all liquid oral drug products formulated for pediatric use …
Matched Categories: … combinations of tetracyclines …

Zilucoplan

Zilucoplan is a 15 amino-acid, synthetic macrocyclic peptide. It is a complement inhibitor that works to prevent the activation of C5, which is a complement protein involved in the innate immune system to initiate inflammatory responses. On October 17, 2023, zilucoplan gained its first FDA approval for the treatment of...
Approved
Matched Description: … It is a complement inhibitor that works to prevent the activation of C5, which is a complement protein ... [A261841] On October 17, 2023, zilucoplan gained its first FDA approval for the treatment of generalized …

Antithymocyte immunoglobulin (rabbit)

Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of...
Approved
Matched Description: … The most common mode of action of Thymoglobulin is via selective depletion of T-cells. ... Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. ... Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for …

Doxorubicin

Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed...
Approved
Investigational
Matched Description: … [A1573,A257614,L45231] However, one of the major side effects of doxorubicin is cardiotoxicity, which ... Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius ... exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of …

Imipramine

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts...
Approved
Matched Description: … TCAs are potent inhibitors of serotonin and norepinephrine reuptake. ... Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Beractant

Beractant is a pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants. Considered a natural source of surfactant as it is made from bovine lung extract, beractant contains a mixture of phospholipids, neutral lipids, fatty acids, and surfactant-associated proteins such as SP-B and SP-C. The...
Approved
Matched Description: … However, in Respiratory Distress Syndrome, developmental deficiency of surfactant results collapse of ... Administration of lung surfactant remains the cornerstone of therapy in this condition that is currently ... the leading cause of death in preterm infants. …

Taurine

Taurine, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in several organs. It plays important role in essential biological processes. This conditional amino acid can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and...
Approved
Nutraceutical
Matched Description: … Taurine, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in ... amino acid can be either be manufactured by the body or obtained in the diet mainly by the consumption of …

Ergotamine

A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
Approved
Matched Description: … A vasoconstrictor found in ergot of Central Europe. ... It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Displaying drugs 226 - 250 of 8131 in total