Migraine

Also known as: Migraines / Migrainous Headache / Headache, Migraine / Migraine Headache / Migraine Headaches / Migraine NOS / Migraine, unspecified / Migraine type headaches / Migraine Disorders

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidAlso known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer [A177325]. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others [L5968]. Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants [FDA label].
DB00918AlmotriptanAlmotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. Almotriptan does not prevent migraine attacks.
DB00321AmitriptylineAmitriptyline hydrochloride, also known as _Elavil_, is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain [A174658]. It was originally approved by the FDA in 1977 and manufactured by Sandoz [L5308].
DB00796Candesartan cilexetilCandesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.
DB01176CyclizineA histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
DB00434CyproheptadineA serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
DB00320DihydroergotamineA 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders.
DB00696ErgotamineA vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
DB03247Flavin mononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
DB14042GalcanezumabLY2951742/galcanezumab is a fully humanized monoclonal antibody against human calcitonin gene-related peptide (CGRP) that is developed by ELi Lilly and Company [A33105]. This therapy is given as a single subcutaneous injection twice a month and ongoing clinical trials for the agent are for episodic and chronic migraine as well as cluster headaches [A33114]. Although various small-molecule CGRP receptor antagonists have also been developed, humanized monoclonal antibodies like galcanezumab are specifically designed to potently and selectively bind to the CGRP entities directly [A33112]. Given this target specificity, lack of off-target toxicity, and characteristic proteolysis profile of immunoglobulin antibodies to not undergo metabolism by liver enzymes, galcanezumab possesses favourable and promising safety and tolerability [A33112].
DB01018GuanfacineA centrally acting antihypertensive agent. The drug lowers both systolic and diastolic blood pressure by activating the central nervous system alpha-2 adrenoreceptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation.
DB01050IbuprofenIbuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics.[A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin.[A39075] Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.[A39076] On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. The S-enantiomer is believed to be the more pharmacologically active enantiomer.[A39194]
DB01009KetoprofenKetoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
DB00722LisinoprilLisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
DB11110Magnesium citrateMagnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used.[T215] Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the specifications of oral administration of a maximum concentration of 237 mg.[L2831] It is also considered as an active ingredient in over-the-counter products.[L1113]
DB01233MetoclopramideA dopamine D2 antagonist that is used as an antiemetic.
DB00264MetoprololMetoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative.[T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.[A175162] Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.[L5527]
DB01203NadololA non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for migraine disorders and for tremor. [PubChem]
DB00788NaproxenAn anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
DB00622NicardipineA potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
DB06153PizotifenPizotifen belongs to the class of antamines and is related to [DB00434] [A32532]. It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. It exhibits weak anticholinergic, antihistamine, and antikinin actions in addition to sedative and appetite-stimulating properties [L2292]. Some patients receiving pizotifen treatment developed tolerance with the prolonged use of the drug [L2292]. Numerous studies have revealed the potential antidepressant effects of pizotifen, which are independent of its antimigraine action [A32538]. While it is suggested that pizotifen may act similarly to the classic tricyclic antidepressants [A32538], its full mechanism of antidepressant action is not fully elucidated. Pizotifen hydrochloride is an active ingredient in Sandomigran, which is used for the prophylactic management of migraines. Sandomigran is available in a number of countries but is not approved by the FDA nor EMA.
DB00571PropranololA widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety.
DB00140RiboflavinNutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.
DB00373TimololA beta-adrenergic antagonist similar in action to propranolol. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor.
DB00273TopiramateTopiramate is a sulfamate-substituted monosaccharide with some activity against carbonic anhydrase.[A175225] It was conceived as part of the efforts to generate analogs of fructose-1,6-diphosphate to block gluconeogenesis in which topiramate was a synthetic intermediate. Analyzing its similarity to acetazolamide, researchers decided to study its capability as an anticonvulsant agent where was shown to be highly active against maximal electroshock seizure and to present a long duration of action.[A175249] Structurally, topiramate does not resemble a normal therapeutic agent as it presents a very high concentration of oxygen. The oxygen atoms in the topiramate molecule are expected to function as acceptors for hydrogen-bond formation while its amide group serves as an important hydrogen donor.[A175249] Topiramate has been approved in Europe since 2003, in the UK in 1995[A175243] and in the US since 2004. This drug has been approved for a number of conditions and in 2014 it was approved for the prevention of migraine in children.[A175231]
DB09270UbidecarenoneUbidecarenone, also known as coenzyme Q10, is a 1,4-benzoquinone, where Q refers to the quinone chemical group, and 10 refers to the number of isoprenyl chemical subunits in its tail.[A7874] It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative phosphorylation.[A31413] The ubidecarenone is the coenzyme destined for mitochondrial enzyme complexes involved in oxidative phosphorylation in the production of ATP. It is fundamental for cells that have a high metabolic demand.[L1062] Ubidecarenone is sold as a dietary supplement and is not FDA approved as a drug thus, it is not meant to treat, cure or prevent any disease. FDA does not approve this dietary supplements before sold nor regulate the manufacturing process.[L1063]
DB00313Valproic AcidValproic acid, supplied as the sodium salt valproate semisodium or divalproex sodium, is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage dependent sodium channels. Typically supplied in the sodium salt form (CAS number: 76584-70-8). Valproic Acid is also a histone deacetylase inhibitor and is under investigation for treatment of HIV and various cancers.
DB00285VenlafaxineVenlafaxine (Effexor) is an antidepressant within the serotonin-norepinephrine reuptake inhibitor (SNRI) class of medications. It exerts its effects primarily by blocking the transporters involved in the reuptake of the neurotransmitters serotonin and norepinephrine, therefore leaving more active neurotransmitter in the synapse. Venlafaxine is officially approved for use in the management of major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder, and panic disorder. As of 2014, Canadian clinical practice guidelines recommend venlafaxine as a first-line option for treatment of generalized anxiety, social anxiety, panic disorder, major depressive disorder (MDD), and consider it a second-line option for management of obsessive-compulsive disorder (OCD) [A177226, A177235]. Venlafaxine is also used off-label for prophylaxis of migraine headaches [A177229], for reduction of vasomotor symptoms associated with menopause [A177238], and for management of neuropathic pain (although there is only minimal evidence of efficacy for this condition) [A177232].
DB00661VerapamilA calcium channel blocker that is a class IV anti-arrhythmia agent.
DB00315ZolmitriptanZolmitriptan is a synthetic tryptamine derivative and appears as a white powder that is readily soluble in water.
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidNuclear factor kappa b beta subunittarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB00918Almotriptan5-hydroxytryptamine receptor 1Dtarget
DB00918Almotriptan5-hydroxytryptamine receptor 1Btarget
DB00918AlmotriptanCytochrome P450 3A4enzyme
DB00918AlmotriptanCytochrome P450 2D6enzyme
DB00918AlmotriptanAmine oxidase [flavin-containing] Aenzyme
DB00918AlmotriptanDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00918AlmotriptanCytochrome P450 2C19enzyme
DB00918AlmotriptanCytochrome P450 2E1enzyme
DB00918AlmotriptanCytochrome P450 2C8enzyme
DB00321AmitriptylineSodium-dependent serotonin transportertarget
DB00321AmitriptylineSodium-dependent noradrenaline transportertarget
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
DB00321AmitriptylineAlpha-2A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 1A2enzyme
DB00321AmitriptylineCytochrome P450 2C19enzyme
DB00321AmitriptylineCytochrome P450 2D6enzyme
DB00321AmitriptylineSerum albumincarrier
DB00321AmitriptylineAlpha-1-acid glycoprotein 1carrier
DB00321AmitriptylineHistamine H1 receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 2Atarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Atarget
DB00321AmitriptylineAlpha-1A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 3A4enzyme
DB00321AmitriptylineCytochrome P450 3A5enzyme
DB00321AmitriptylinePotassium voltage-gated channel subfamily A member 1target
DB00321AmitriptylineAlpha-1D adrenergic receptortarget
DB00321AmitriptylineDelta-type opioid receptortarget
DB00321AmitriptylineKappa-type opioid receptortarget
DB00321AmitriptylineHigh affinity nerve growth factor receptortarget
DB00321AmitriptylineBDNF/NT-3 growth factors receptortarget
DB00321AmitriptylineCytochrome P450 2C9enzyme
DB00321AmitriptylineCytochrome P450 2B6enzyme
DB00321AmitriptylineCytochrome P450 2C8enzyme
DB00321AmitriptylineHistamine H2 receptortarget
DB00321AmitriptylineHistamine H4 receptortarget
DB00321AmitriptylineSigma non-opioid intracellular receptor 1target
DB00321Amitriptyline5-hydroxytryptamine receptor 2Ctarget
DB00321AmitriptylineAlpha-1B adrenergic receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 7target
DB00321Amitriptyline5-hydroxytryptamine receptor 1Dtarget
DB00321AmitriptylineMu-type opioid receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Btarget
DB00321Amitriptyline5-hydroxytryptamine receptor 6target
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
DB00321AmitriptylineUDP-glucuronosyltransferase 1-1enzyme
DB00321Amitriptyline5-hydroxytryptamine receptor 1Ctarget
DB00321AmitriptylineMuscarinic acetylcholine receptortarget
DB00321AmitriptylineHERG human cardiac K+ channeltarget
DB00321AmitriptylineMultidrug resistance protein 1transporter
DB00796Candesartan cilexetilType-1 angiotensin II receptortarget
DB00796Candesartan cilexetilCytochrome P450 2C8enzyme
DB00796Candesartan cilexetilCytochrome P450 2C9enzyme
DB00796Candesartan cilexetilMultidrug resistance protein 1transporter
DB00796Candesartan cilexetilUDP-glucuronosyltransferase 1-3enzyme
DB00796Candesartan cilexetilProstaglandin G/H synthase 1enzyme
DB01176CyclizineHistamine H1 receptortarget
DB01176CyclizineEstrogen sulfotransferasetarget
DB01176CyclizineCytochrome P450 2C9enzyme
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Atarget
DB00434CyproheptadineHistamine H1 receptortarget
DB00434CyproheptadineMuscarinic acetylcholine receptor M1target
DB00434CyproheptadineMuscarinic acetylcholine receptor M2target
DB00434CyproheptadineMuscarinic acetylcholine receptor M3target
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Ctarget
DB00434CyproheptadineUDP-glucuronosyltransferase 1-3enzyme
DB00434Cyproheptadine5-hydroxytryptamine receptor 7target
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Dtarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Btarget
DB00320DihydroergotamineCytochrome P450 3A4enzyme
DB00320DihydroergotamineAlpha-2A adrenergic receptortarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 2Btarget
DB00320DihydroergotamineMultidrug resistance protein 1transporter
DB00696ErgotamineAlpha-1A adrenergic receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Dtarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Btarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Atarget
DB00696ErgotamineAlpha-2A adrenergic receptortarget
DB00696ErgotamineD(2) dopamine receptortarget
DB00696ErgotamineAlpha-2B adrenergic receptortarget
DB00696ErgotamineSodium-dependent noradrenaline transportertarget
DB00696ErgotamineCytochrome P450 3A4enzyme
DB00696ErgotamineAlpha-1B adrenergic receptortarget
DB00696ErgotamineAlpha-1D adrenergic receptortarget
DB00696ErgotamineMultidrug resistance protein 1transporter
DB00696ErgotamineD(1) dopamine receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Atarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Ftarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Ctarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Btarget
DB03247Flavin mononucleotideFlavin reductase (NADPH)target
DB03247Flavin mononucleotideHydroxyacid oxidase 1target
DB03247Flavin mononucleotidePyridoxine-5'-phosphate oxidasetarget
DB03247Flavin mononucleotideMajor NAD(P)H-flavin oxidoreductasetarget
DB03247Flavin mononucleotideRiboflavin kinasetarget
DB03247Flavin mononucleotideOxygen-insensitive NADPH nitroreductasetarget
DB03247Flavin mononucleotideNitric oxide synthase, braintarget
DB03247Flavin mononucleotideDihydroorotate dehydrogenase (quinone)target
DB03247Flavin mononucleotideDihydropyrimidine dehydrogenase [NADP(+)]target
DB03247Flavin mononucleotideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB03247Flavin mononucleotideFlavodoxintarget
DB03247Flavin mononucleotideOxygen-insensitive NAD(P)H nitroreductasetarget
DB03247Flavin mononucleotideChorismate synthasetarget
DB03247Flavin mononucleotide2,4-dienoyl-CoA reductase [NADPH]target
DB03247Flavin mononucleotideDihydroorotate dehydrogenase A (fumarate)target
DB03247Flavin mononucleotidePyridoxine/pyridoxamine 5'-phosphate oxidasetarget
DB03247Flavin mononucleotidePentaerythritol tetranitrate reductasetarget
DB03247Flavin mononucleotideFMN-dependent NADH-azoreductasetarget
DB03247Flavin mononucleotideEpidermin decarboxylasetarget
DB03247Flavin mononucleotideFMN-dependent NADH-azoreductasetarget
DB03247Flavin mononucleotideChorismate synthasetarget
DB03247Flavin mononucleotideFlavodoxintarget
DB03247Flavin mononucleotideFlavodoxintarget
DB03247Flavin mononucleotideFlavodoxintarget
DB03247Flavin mononucleotidePutative uncharacterized proteintarget
DB03247Flavin mononucleotidePutative monooxygenase MoxCtarget
DB03247Flavin mononucleotidetRNA-dihydrouridine synthasetarget
DB03247Flavin mononucleotideProtein NrdItarget
DB03247Flavin mononucleotideProbable aromatic acid decarboxylasetarget
DB03247Flavin mononucleotide(S)-mandelate dehydrogenasetarget
DB03247Flavin mononucleotideFMN-dependent NADPH-azoreductasetarget
DB03247Flavin mononucleotideFlavodoxintarget
DB03247Flavin mononucleotideSerine/threonine-protein kinase Sgk1target
DB03247Flavin mononucleotideOxygen-insensitive NAD(P)H nitroreductasetarget
DB03247Flavin mononucleotideNitric oxide reductasetarget
DB03247Flavin mononucleotideIsopentenyl-diphosphate delta-isomerasetarget
DB03247Flavin mononucleotideTrimethylamine dehydrogenasetarget
DB03247Flavin mononucleotideRubredoxin-oxygen oxidoreductasetarget
DB03247Flavin mononucleotideRiboflavin biosynthesis protein RibFtarget
DB03247Flavin mononucleotideMorphinone reductasetarget
DB03247Flavin mononucleotideNADPH-flavin oxidoreductasetarget
DB03247Flavin mononucleotideRibosomal protein S6 kinase alpha-4target
DB03247Flavin mononucleotidePhenazine biosynthesis protein PhzGtarget
DB03247Flavin mononucleotideHydroxyacid oxidase 2target
DB03247Flavin mononucleotideNAD(P)H dehydrogenase (quinone)target
DB03247Flavin mononucleotideFlavodoxin-1target
DB03247Flavin mononucleotideIsopentenyl-diphosphate delta-isomerasetarget
DB03247Flavin mononucleotideNADH dehydrogenasetarget
DB03247Flavin mononucleotideFMN-binding proteintarget
DB03247Flavin mononucleotideNitroreductase family proteintarget
DB03247Flavin mononucleotideNADPH--cytochrome P450 reductasetarget
DB03247Flavin mononucleotidePhosphopantothenoylcysteine decarboxylasetarget
DB03247Flavin mononucleotidePhzGtarget
DB03247Flavin mononucleotideFerredoxin-dependent glutamate synthase 2target
DB03247Flavin mononucleotideNADPH--cytochrome P450 reductaseenzyme
DB14042GalcanezumabCalcitonin gene-related peptide 1target
DB14042GalcanezumabCalcitonin gene-related peptide 2target
DB01018GuanfacineAlpha-2A adrenergic receptortarget
DB01018GuanfacineCytochrome P450 2C19enzyme
DB01018GuanfacineCytochrome P450 3A4enzyme
DB01018GuanfacineAlpha-2B adrenergic receptortarget
DB01050IbuprofenProstaglandin G/H synthase 1target
DB01050IbuprofenProstaglandin G/H synthase 2target
DB01050IbuprofenCytochrome P450 2C9enzyme
DB01050IbuprofenSerum albumincarrier
DB01050IbuprofenMultidrug resistance-associated protein 4transporter
DB01050IbuprofenMultidrug resistance-associated protein 1transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 1A2transporter
DB01050IbuprofenSolute carrier family 22 member 6transporter
DB01050IbuprofenSolute carrier family 22 member 8transporter
DB01050IbuprofenSolute carrier family 22 member 11transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 2B1transporter
DB01050IbuprofenMultidrug resistance protein 1transporter
DB01050IbuprofenUDP-glucuronosyltransferase 1-3enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1-9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B4enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenCytochrome P450 2C8enzyme
DB01050IbuprofenCytochrome P450 2C19enzyme
DB01050IbuprofenApoptosis regulator Bcl-2target
DB01050IbuprofenThrombomodulintarget
DB01050IbuprofenFatty acid-binding protein, intestinaltarget
DB01050IbuprofenPeroxisome proliferator-activated receptor gammatarget
DB01050IbuprofenCystic fibrosis transmembrane conductance regulatortarget
DB01050IbuprofenPeroxisome proliferator-activated receptor alphatarget
DB01050IbuprofenPlatelet glycoprotein Ib alpha chaintarget
DB01050IbuprofenProtein S100-A7target
DB01050IbuprofenAlpha-methylacyl-CoA racemaseenzyme
DB01009KetoprofenProstaglandin G/H synthase 1target
DB01009KetoprofenProstaglandin G/H synthase 2target
DB01009KetoprofenC-X-C chemokine receptor type 1target
DB01009KetoprofenSerum albumincarrier
DB01009KetoprofenMultidrug resistance-associated protein 4transporter
DB01009KetoprofenSolute carrier organic anion transporter family member 1A2transporter
DB01009KetoprofenSolute carrier family 22 member 6transporter
DB01009KetoprofenSolute carrier family 22 member 8transporter
DB01009KetoprofenSolute carrier family 22 member 11transporter
DB01009KetoprofenSolute carrier family 22 member 7transporter
DB01009KetoprofenCytochrome P450 2C9enzyme
DB01009KetoprofenCytochrome P450 2C8enzyme
DB01009KetoprofenUDP-glucuronosyltransferase 1-1enzyme
DB00722LisinoprilAngiotensin-converting enzymetarget
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideD(2) dopamine receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233MetoclopramideCytochrome P450 11B1, mitochondrialenzyme
DB01233MetoclopramideCytochrome P450 11B2, mitochondrialenzyme
DB01233MetoclopramideSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01233MetoclopramideAcetylcholinesterasetarget
DB00264MetoprololBeta-1 adrenergic receptortarget
DB00264MetoprololCytochrome P450 2D6enzyme
DB00264MetoprololBeta-2 adrenergic receptortarget
DB00264MetoprololSolute carrier family 22 member 2transporter
DB00264MetoprololMultidrug resistance protein 1transporter
DB00264MetoprololSerum albumincarrier
DB00264MetoprololCytochrome P450 3A4enzyme
DB01203NadololBeta-1 adrenergic receptortarget
DB01203NadololBeta-2 adrenergic receptortarget
DB01203NadololMultidrug resistance protein 1transporter
DB01203NadololCytochrome P450 2D6enzyme
DB00788NaproxenProstaglandin G/H synthase 1target
DB00788NaproxenProstaglandin G/H synthase 2target
DB00788NaproxenSerum albumincarrier
DB00788NaproxenCytochrome P450 2C9enzyme
DB00788NaproxenCytochrome P450 1A2enzyme
DB00788NaproxenSolute carrier organic anion transporter family member 1A2transporter
DB00788NaproxenSolute carrier family 22 member 6transporter
DB00788NaproxenCytochrome P450 2C8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-1enzyme
DB00788NaproxenUDP-glucuronosyltransferase 2B7enzyme
DB00788NaproxenPeptostreptococcal albumin-binding proteintarget
DB00788NaproxenBile salt export pumptransporter
DB00788NaproxenMultidrug resistance protein 1transporter
DB00622NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00622NicardipineCytochrome P450 3A4enzyme
DB00622NicardipineCytochrome P450 2C19enzyme
DB00622NicardipineCytochrome P450 2C8enzyme
DB00622NicardipineCytochrome P450 2D6enzyme
DB00622NicardipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Btarget
DB00622NicardipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Atarget
DB00622NicardipineAlpha-1A adrenergic receptortarget
DB00622NicardipineAlpha-1D adrenergic receptortarget
DB00622NicardipineAlpha-1B adrenergic receptortarget
DB00622NicardipineMuscarinic acetylcholine receptor M1target
DB00622NicardipineMuscarinic acetylcholine receptor M2target
DB00622NicardipineMuscarinic acetylcholine receptor M3target
DB00622NicardipineMuscarinic acetylcholine receptor M4target
DB00622NicardipineMuscarinic acetylcholine receptor M5target
DB00622NicardipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00622NicardipineVoltage-dependent L-type calcium channel subunit beta-2target
DB00622NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00622NicardipineCalmodulintarget
DB00622NicardipineMultidrug resistance protein 1transporter
DB00622NicardipineCytochrome P450 2B6enzyme
DB00622NicardipineCytochrome P450 2E1enzyme
DB00622NicardipineCytochrome P450 3A5enzyme
DB00622NicardipineSolute carrier organic anion transporter family member 1B1transporter
DB00622NicardipineBile salt export pumptransporter
DB06153PizotifenMuscarinic acetylcholine receptor M2target
DB06153PizotifenMuscarinic acetylcholine receptor M1target
DB06153PizotifenMuscarinic acetylcholine receptor M3target
DB06153Pizotifen5-hydroxytryptamine receptor 2Atarget
DB06153Pizotifen5-hydroxytryptamine receptor 2Btarget
DB06153Pizotifen5-hydroxytryptamine receptor 2Ctarget
DB06153PizotifenHistamine H1 receptortarget
DB06153Pizotifen5-hydroxytryptamine receptor 1Atarget
DB06153Pizotifen5-hydroxytryptamine receptor 1Btarget
DB06153Pizotifen5-hydroxytryptamine receptor 1Dtarget
DB06153PizotifenAlpha-1A adrenergic receptortarget
DB06153PizotifenAlpha-1B adrenergic receptortarget
DB06153PizotifenAlpha-1D adrenergic receptortarget
DB06153PizotifenAlpha-2A adrenergic receptortarget
DB06153PizotifenAlpha-2B adrenergic receptortarget
DB06153PizotifenAlpha-2C adrenergic receptortarget
DB06153PizotifenUDP-glucuronosyltransferase 2B10enzyme
DB00571PropranololBeta-1 adrenergic receptortarget
DB00571PropranololBeta-2 adrenergic receptortarget
DB00571PropranololBeta-3 adrenergic receptortarget
DB00571Propranolol5-hydroxytryptamine receptor 1Atarget
DB00571Propranolol5-hydroxytryptamine receptor 1Btarget
DB00571PropranololCytochrome P450 1A2enzyme
DB00571PropranololCytochrome P450 2D6enzyme
DB00571PropranololAlpha-1-acid glycoprotein 1carrier
DB00571PropranololCytochrome P450 2C19enzyme
DB00571PropranololCytochrome P450 3A4enzyme
DB00571PropranololCytochrome P450 3A5enzyme
DB00571PropranololCytochrome P450 3A7enzyme
DB00571PropranololSolute carrier family 22 member 2transporter
DB00571PropranololMultidrug resistance protein 1transporter
DB00571PropranololCytochrome P450 1A1enzyme
DB00571PropranololAmine oxidase [flavin-containing] Aenzyme
DB00140RiboflavinFlavin reductase (NADPH)target
DB00140RiboflavinRiboflavin kinasetarget
DB00140RiboflavinRiboflavin synthasetarget
DB00140RiboflavinAmine oxidase [flavin-containing] Aenzyme
DB00140RiboflavinMethylenetetrahydrofolate reductaseenzyme
DB00140RiboflavinSolute carrier family 22 member 6transporter
DB00373TimololBeta-1 adrenergic receptortarget
DB00373TimololBeta-2 adrenergic receptortarget
DB00373TimololCytochrome P450 2D6enzyme
DB00373TimololMultidrug resistance protein 1transporter
DB00373TimololCytochrome P450 2C19enzyme
DB00373TimololLysozymetarget
DB00273TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
DB00273TopiramateSodium channel protein type 1 subunit alphatarget
DB00273TopiramateCarbonic anhydrase 2target
DB00273TopiramateCarbonic anhydrase 4target
DB00273TopiramateGlutamate receptor ionotropic, kainate 1target
DB00273TopiramateCytochrome P450 2C19enzyme
DB00273TopiramateCytochrome P450 3A4enzyme
DB00273TopiramateGABA-A receptor (anion channel)target
DB00273TopiramateCarbonic anhydrase 1target
DB00273TopiramateCarbonic anhydrase 3target
DB00273TopiramateGlutamate receptor 1target
DB09270UbidecarenoneNADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialtarget
DB09270UbidecarenoneSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialtarget
DB09270UbidecarenoneLow-density lipoprotein receptorcarrier
DB09270UbidecarenoneVery low-density lipoprotein receptorcarrier
DB09270UbidecarenoneMultidrug resistance protein 1transporter
DB09270Ubidecarenone3-hydroxy-3-methylglutaryl-coenzyme A reductaseenzyme
DB00313Valproic Acid4-aminobutyrate aminotransferase, mitochondrialtarget
DB00313Valproic AcidHistone deacetylase 9target
DB00313Valproic AcidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
DB00313Valproic AcidCytochrome P450 2A6enzyme
DB00313Valproic AcidCytochrome P450 2B6enzyme
DB00313Valproic AcidCytochrome P450 2C9enzyme
DB00313Valproic AcidSolute carrier family 22 member 5transporter
DB00313Valproic AcidSolute carrier family 22 member 6transporter
DB00313Valproic AcidSolute carrier family 22 member 8transporter
DB00313Valproic AcidMonocarboxylate transporter 1transporter
DB00313Valproic AcidSolute carrier family 22 member 7transporter
DB00313Valproic AcidCytochrome P450 3A5enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-9enzyme
DB00313Valproic AcidProstaglandin G/H synthase 1enzyme
DB00313Valproic AcidCytochrome P450 1A2enzyme
DB00313Valproic AcidCytochrome P450 2C18enzyme
DB00313Valproic AcidCytochrome P450 2C19enzyme
DB00313Valproic AcidCytochrome P450 2C8enzyme
DB00313Valproic AcidCytochrome P450 3A4enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-4enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-8enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-10enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-6enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-3enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 2B7enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 2B15enzyme
DB00313Valproic Acid2-oxoglutarate dehydrogenase, mitochondrialtarget
DB00313Valproic AcidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
DB00313Valproic AcidSodium channel proteintarget
DB00313Valproic AcidHistone deacetylase 2target
DB00313Valproic AcidPeroxisome proliferator-activated receptor alphatarget
DB00313Valproic AcidPeroxisome proliferator-activated receptor deltatarget
DB00313Valproic AcidPeroxisome proliferator-activated receptor gammatarget
DB00313Valproic AcidSerum albumincarrier
DB00313Valproic AcidUDP-glucuronosyltransferase 1-1enzyme
DB00313Valproic AcidSolute carrier organic anion transporter family member 2B1transporter
DB00285VenlafaxineSodium-dependent serotonin transportertarget
DB00285VenlafaxineSodium-dependent noradrenaline transportertarget
DB00285VenlafaxineCytochrome P450 2D6enzyme
DB00285VenlafaxineCytochrome P450 3A4enzyme
DB00285VenlafaxineSodium-dependent dopamine transportertarget
DB00285VenlafaxineMultidrug resistance protein 1transporter
DB00285VenlafaxineATP-binding cassette sub-family G member 2transporter
DB00661VerapamilSodium channel protein type 5 subunit alphatarget
DB00661VerapamilATP-sensitive inward rectifier potassium channel 11target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-4target
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-3target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-1target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-2target
DB00661VerapamilPotassium voltage-gated channel subfamily H member 2target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB00661VerapamilCytochrome P450 1A2enzyme
DB00661VerapamilCytochrome P450 3A5enzyme
DB00661VerapamilVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00661VerapamilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB00661VerapamilSodium-dependent serotonin transportertarget
DB00661VerapamilCytochrome P450 3A4enzyme
DB00661VerapamilCytochrome P450 3A7enzyme
DB00661VerapamilMultidrug resistance protein 1transporter
DB00661VerapamilSolute carrier family 22 member 1transporter
DB00661VerapamilCanalicular multispecific organic anion transporter 2transporter
DB00661VerapamilMultidrug resistance-associated protein 4transporter
DB00661VerapamilSolute carrier family 22 member 5transporter
DB00661VerapamilMultidrug resistance-associated protein 1transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1A2transporter
DB00661VerapamilMultidrug resistance-associated protein 7transporter
DB00661VerapamilCanalicular multispecific organic anion transporter 1transporter
DB00661VerapamilSolute carrier family 22 member 4transporter
DB00661VerapamilATP-binding cassette sub-family G member 2transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1B1transporter
DB00661VerapamilCytochrome P450 2C8enzyme
DB00661VerapamilCytochrome P450 2C9enzyme
DB00661VerapamilCytochrome P450 2C18enzyme
DB00661VerapamilCytochrome P450 2B6enzyme
DB00661VerapamilCytochrome P450 2C19enzyme
DB00661VerapamilCytochrome P450 2D6enzyme
DB00661VerapamilAlpha-1A adrenergic receptortarget
DB00661VerapamilAlpha-1B adrenergic receptortarget
DB00661VerapamilAlpha-1D adrenergic receptortarget
DB00661VerapamilBile salt export pumptransporter
DB00315Zolmitriptan5-hydroxytryptamine receptor 1Dtarget
DB00315Zolmitriptan5-hydroxytryptamine receptor 1Btarget
DB00315Zolmitriptan5-hydroxytryptamine receptor 1Ftarget
DB00315ZolmitriptanCytochrome P450 1A2enzyme
DB00315ZolmitriptanAmine oxidase [flavin-containing] Aenzyme
DB00315Zolmitriptan5-hydroxytryptamine receptor 1Atarget
DrugDrug NamePhaseStatusCount
DB11677Triheptanoin0Not Yet Recruiting1
DB00404Alprazolam1Completed1
DB06774Capsaicin1Active Not Recruiting1
DB00482Celecoxib1Completed1
DB00341Cetirizine1Terminated1
DB01234Dexamethasone1Recruiting1
DB00320Dihydroergotamine1Completed2
DB01240Epoprostenol1Terminated1
DB14039Erenumab1Completed4
DB04841Flunarizine1Completed1
DB14042Galcanezumab1Completed1
DB05266Ibudilast1Completed1
DB11732Lasmiditan1Completed4
DB00408Loxapine1Completed1
DB00218Moxifloxacin1Completed1
DB00788Naproxen1Completed1
DB00433Prochlorperazine1Completed1
DB11664Psilocybine1Recruiting1
DB12457Rimegepant1Completed1
DB09153Sodium chloride1Completed1
DB00669Sumatriptan1Active Not Recruiting1
DB00669Sumatriptan1Completed4
DB05760Telcagepant1Completed1
DB12228Telcagepant1Completed3
DB00273Topiramate1Completed2
DB00273Topiramate1Not Yet Recruiting2
DB00315Zolmitriptan1Completed3
DB00297Bupivacaine1 / 2Recruiting1
DB01234Dexamethasone1 / 2Recruiting1
DB00593Ethosuximide1 / 2Terminated1
DB00465Ketorolac1 / 2Recruiting1
DB00952Naratriptan1 / 2Recruiting1
DB00104Octreotide1 / 2Unknown Status1
DB09153Sodium chloride1 / 2Completed1
DB09145Water1 / 2Completed1
DB05070ADX100592Terminated1
DB00316Acetaminophen2Completed1
DB00321Amitriptyline2Recruiting1
DB00083Botulinum toxin type A2Completed1
DB00083Botulinum toxin type A2Recruiting1
DB00297Bupivacaine2Completed1
DB09157Carbon dioxide2Terminated1
DB05821DP-VPA2Withdrawn1
DB11074Dimethicone2Not Yet Recruiting1
DB00843Donepezil2Completed1
DB14039Erenumab2Active Not Recruiting2
DB09119Eslicarbazepine acetate2Completed1
DB00977Ethinylestradiol2Completed1
DB12158Filorexant2Completed1
DB12237GW-2741502Completed1
DB04922Gabapentin enacarbil2Completed1
DB14042Galcanezumab2Completed3
DB01050Ibuprofen2Completed1
DB00465Ketorolac2Completed1
DB13016LY-23005592Terminated1
DB06218Lacosamide2Completed1
DB04465Lactose2Withdrawn1
DB11732Lasmiditan2Completed1
DB00367Levonorgestrel2Completed1
DB01627Lincomycin2Completed1
DB12424MK-32072Completed1
DB01065Melatonin2Completed1
DB01065Melatonin2Recruiting2
DB01233Metoclopramide2Completed1
DB00540Nortriptyline2Not Yet Recruiting1
DB09140Oxygen2Completed1
DB11058Petrolatum2Not Yet Recruiting1
DB00980Ramelteon2Terminated1
DB00953Rizatriptan2Completed1
DB12367Selurampanel2Completed1
DB00641Simvastatin2Completed1
DB00669Sumatriptan2Completed1
DB00669Sumatriptan2Recruiting1
DB00669Sumatriptan2Terminated1
DB05760Telcagepant2Completed1
DB12228Telcagepant2Completed2
DB05760Telcagepant2Terminated1
DB12228Telcagepant2Terminated1
DB06354Tezampanel2Completed1
DB00373Timolol2Completed1
DB00273Topiramate2Completed2
DB00273Topiramate2Terminated1
DB00909Zonisamide2Completed1
DB00201Caffeine2 / 3Recruiting1
DB14041Fremanezumab2 / 3Recruiting2
DB00788Naproxen2 / 3Completed1
DB00818Propofol2 / 3Completed1
DB12457Rimegepant2 / 3Active Not Recruiting1
DB12457Rimegepant2 / 3Recruiting1
DB00669Sumatriptan2 / 3Completed1
DB05760Telcagepant2 / 3Completed1
DB12228Telcagepant2 / 3Completed1
DB00316Acetaminophen3Suspended1
DB00945Acetylsalicylic acid3Completed1
DB00918Almotriptan3Completed2
DB00321Amitriptyline3Completed1
DB00321Amitriptyline3Terminated1
DB00297Bupivacaine3Completed1
DB00482Celecoxib3Active Not Recruiting2
DB00758Clopidogrel3Completed1
DB01234Dexamethasone3Completed2
DB00320Dihydroergotamine3Not Yet Recruiting1
DB01075Diphenhydramine3Completed1
DB14039Erenumab3Completed2
DB14039Erenumab3Not Yet Recruiting3
DB14039Erenumab3Recruiting1
DB14041Fremanezumab3Completed2
DB14041Fremanezumab3Recruiting1
DB00998Frovatriptan3Completed2
DB14042Galcanezumab3Active Not Recruiting3
DB14042Galcanezumab3Completed2
DB01009Ketoprofen3Completed1
DB01009Ketoprofen3Withdrawn1
DB00465Ketorolac3Recruiting1
DB11732Lasmiditan3Not Yet Recruiting1
DB00281Lidocaine3Recruiting1
DB01065Melatonin3Completed1
DB00814Meloxicam3Recruiting1
DB00331Metformin3Active Not Recruiting1
DB01233Metoclopramide3Completed1
DB01233Metoclopramide3Withdrawn1
DB00788Naproxen3Completed3
DB00788Naproxen3Withdrawn2
DB00952Naratriptan3Withdrawn2
DB00571Propranolol3Completed1
DB12457Rimegepant3Completed1
DB00953Rizatriptan3Completed8
DB00953Rizatriptan3Recruiting1
DB09153Sodium chloride3Recruiting1
DB00669Sumatriptan3Completed10
DB12228Telcagepant3Completed4
DB00273Topiramate3Completed12
DB00273Topiramate3Terminated1
DB00313Valproic Acid3Completed3
DB00315Zolmitriptan3Completed3
DB00316Acetaminophen4Terminated1
DB08842Acetylcarnitine4Completed1
DB00918Almotriptan4Completed2
DB00083Botulinum toxin type A4Recruiting1
DB00297Bupivacaine4Completed1
DB00297Bupivacaine4Recruiting2
DB00201Caffeine4Terminated1
DB00758Clopidogrel4Completed1
DB00758Clopidogrel4Not Yet Recruiting1
DB01234Dexamethasone4Completed2
DB09214Dexketoprofen4Completed1
DB00586Diclofenac4Completed1
DB00586Diclofenac4Recruiting1
DB01075Diphenhydramine4Completed3
DB01075Diphenhydramine4Terminated1
DB00476Duloxetine4Completed1
DB00216Eletriptan4Completed4
DB00668Epinephrine4Completed1
DB14039Erenumab4Not Yet Recruiting1
DB14039Erenumab4Recruiting1
DB00402Eszopiclone4Completed1
DB00998Frovatriptan4Completed1
DB00502Haloperidol4Completed1
DB00502Haloperidol4Terminated1
DB00327Hydromorphone4Completed1
DB01050Ibuprofen4Completed1
DB01221Ketamine4Recruiting1
DB00465Ketorolac4Completed1
DB00465Ketorolac4Recruiting2
DB00465Ketorolac4Withdrawn1
DB00281Lidocaine4Completed1
DB00281Lidocaine4Recruiting2
DB00959Methylprednisolone4Completed2
DB01233Metoclopramide4Completed5
DB01233Metoclopramide4Recruiting1
DB01233Metoclopramide4Terminated1
DB01203Nadolol4Completed1
DB00788Naproxen4Completed7
DB00433Prochlorperazine4Completed2
DB00433Prochlorperazine4Terminated1
DB00571Propranolol4Completed1
DB00980Ramelteon4Terminated1
DB00953Rizatriptan4Completed4
DB00296Ropivacaine4Recruiting1
DB09153Sodium chloride4Recruiting3
DB00669Sumatriptan4Completed10
DB08816Ticagrelor4Active Not Recruiting1
DB00273Topiramate4Completed3
DB00273Topiramate4Not Yet Recruiting1
DB01593Zinc4Completed2
DB00315Zolmitriptan4Completed2
DB00909Zonisamide4Withdrawn1
DB00819AcetazolamideNot AvailableCompleted1
DB00819AcetazolamideNot AvailableUnknown Status1
DB00802AlfentanilNot AvailableRecruiting1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic AcidNot AvailableRecruiting1
DB00321AmitriptylineNot AvailableCompleted2
DB00181BaclofenNot AvailableCompleted1
DB00559BosentanNot AvailableRecruiting1
DB00083Botulinum toxin type ANot AvailableRecruiting1
DB00083Botulinum toxin type ANot AvailableTerminated1
DB00297BupivacaineNot AvailableCompleted1
DB06774CapsaicinNot AvailableCompleted1
DB01413CefepimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableRecruiting1
DB01166CilostazolNot AvailableCompleted2
DB01166CilostazolNot AvailableRecruiting2
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB00924CyclobenzaprineNot AvailableCompleted1
DB09255DextranNot AvailableCompleted1
DB00586DiclofenacNot AvailableCompleted1
DB00320DihydroergotamineNot AvailableCompleted1
DB00917DinoprostoneNot AvailableCompleted1
DB01075DiphenhydramineNot AvailableRecruiting1
DB00254DoxycyclineNot AvailableWithdrawn1
DB00476DuloxetineNot AvailableCompleted1
DB00216EletriptanNot AvailableCompleted1
DB00668EpinephrineNot AvailableCompleted2
DB01240EpoprostenolNot AvailableUnknown Status1
DB06215FerumoxytolNot AvailableRecruiting1
DB04841FlunarizineNot AvailableCompleted1
DB04841FlunarizineNot AvailableRecruiting1
DB00712FlurbiprofenNot AvailableCompleted1
DB00828FosfomycinNot AvailableRecruiting1
DB14041FremanezumabNot AvailableAvailable1
DB00998FrovatriptanNot AvailableCompleted2
DB00996GabapentinNot AvailableCompleted1
DB09462GlycerinNot AvailableCompleted1
DB00502HaloperidolNot AvailableRecruiting1
DB11075HypromelloseNot AvailableCompleted1
DB01020Isosorbide MononitrateNot AvailableCompleted1
DB01221KetamineNot AvailableCompleted1
DB01009KetoprofenNot AvailableCompleted1
DB00465KetorolacNot AvailableRecruiting1
DB00598LabetalolNot AvailableRecruiting1
DB01202LevetiracetamNot AvailableCompleted1
DB00825LevomentholNot AvailableCompleted2
DB00281LidocaineNot AvailableCompleted3
DB00281LidocaineNot AvailableTerminated1
DB08815LurasidoneNot AvailableRecruiting1
DB00814MeloxicamNot AvailableCompleted1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB01233MetoclopramideNot AvailableRecruiting1
DB11057Mineral oilNot AvailableCompleted1
DB01618MolindoneNot AvailableRecruiting1
DB00607NafcillinNot AvailableRecruiting1
DB00788NaproxenNot AvailableCompleted1
DB00788NaproxenNot AvailableUnknown Status1
DB00788NaproxenNot AvailableWithdrawn1
DB00952NaratriptanNot AvailableCompleted2
DB01115NifedipineNot AvailableRecruiting1
DB06690Nitrous oxideNot AvailableCompleted1
DB00497OxycodoneNot AvailableRecruiting1
DB00652PentazocineNot AvailableCompleted1
DB00312PentobarbitalNot AvailableRecruiting1
DB11058PetrolatumNot AvailableCompleted1
DB11077Polyethylene glycol 400Not AvailableCompleted1
DB11060Polyvinyl alcoholNot AvailableCompleted1
DB11061PovidoneNot AvailableCompleted1
DB00750PrilocaineNot AvailableCompleted1
DB00818PropofolNot AvailableRecruiting1
DB00818PropofolNot AvailableTerminated1
DB00571PropranololNot AvailableUnknown Status2
DB00953RizatriptanNot AvailableCompleted1
DB00728RocuroniumNot AvailableRecruiting1
DB00296RopivacaineNot AvailableCompleted1
DB00658SevelamerNot AvailableRecruiting1
DB09153Sodium chlorideNot AvailableCompleted1
DB09153Sodium chlorideNot AvailableRecruiting1
DB09153Sodium chlorideNot AvailableTerminated1
DB14101Soy isoflavonesNot AvailableCompleted1
DB00421SpironolactoneNot AvailableRecruiting1
DB00669SumatriptanNot AvailableCompleted6
DB00669SumatriptanNot AvailableRecruiting1
DB00669SumatriptanNot AvailableUnknown Status1
DB00669SumatriptanNot AvailableWithdrawn2
DB00697TizanidineNot AvailableCompleted1
DB00684TobramycinNot AvailableRecruiting1
DB00273TopiramateNot AvailableCompleted3
DB00273TopiramateNot AvailableUnknown Status2
DB00273TopiramateNot AvailableWithdrawn2
DB00302Tranexamic acidNot AvailableRecruiting1
DB00620TriamcinoloneNot AvailableCompleted1
DB00512VancomycinNot AvailableRecruiting1
DB01339VecuroniumNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableRecruiting1
DB00909ZonisamideNot AvailableUnknown Status1