Glycine - DrugBank

ID Pharmacology Interactions References Trials Economics Properties Spectra Taxonomy

Targets (31)Transporters (1)

Targets (31)Transporters (1)Biointeractions (3)

Identification

Name

Glycine

Accession Number

DB00145 (NUTR00028)

Type

Small Molecule

Groups

Approved, Nutraceutical, Vet Approved

Description

A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Aminoacetic acid

Aminoessigsäure

Aminoethanoic acid

Gly

Glycin

Glycocoll

Glykokoll

Glyzin

Leimzucker

External IDs

FEMA NO. 3287

Product Ingredients

Not Available

Approved Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Glycine	Irrigant	1.5 g/100mL	Irrigation	B. Braun Medical Inc.	1978-02-06	Not applicable	US
Glycine	Irrigant	1.5 g/100mL	Irrigation	B. Braun Medical Inc.	2013-12-04	Not applicable	US
Glycine	Solution	1.5 g/100mL	Irrigation	Baxter Laboratories	1980-05-30	Not applicable	US
Glycine	Irrigant	1.5 g/100mL	Irrigation	Hospira, Inc.	1980-02-22	Not applicable	US
Glycine 1.5% Irrigation	Solution	15 mg	Irrigation	Hospira, Inc.	1980-12-31	Not applicable	Canada
Glycine 1.5% Irrigation USP Sol	Liquid	1.5 g	Irrigation	Baxter Laboratories	1989-12-31	Not applicable	Canada
Glycine Irrigation 1.5% USP	Liquid	1.5 %	Irrigation	B. Braun Medical Inc.	1992-12-31	Not applicable	Canada

Approved Generic Prescription Products

Not Available

Approved Over the Counter Products

Not Available

Unapproved/Other Products

Not Available

International Brands

Name	Company
Gyn-Hydralin	Not Available

Brand mixtures

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-12-31	2015-08-05	Canada
2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1993-12-31	2015-08-05	Canada
2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1995-12-31	2007-08-02	Canada
2.5%travasol Amino Acid InJ.W.eleC.W.25%dex	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Liquid	Intravenous	Clintec Nutrition Company	1996-07-30	1998-08-13	Canada
2.75% Travas. Amino Acid InJ.W.elecw.25%dex	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Liquid	Intravenous	Clintec Nutrition Company	1996-07-30	1998-08-13	Canada
2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-02-02	2007-08-02	Canada
2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1993-12-31	2007-08-02	Canada
2.75%travasol Amino Acid InJ.W.eleC.W.5%dex.	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Liquid	Intravenous	Clintec Nutrition Company	1996-12-31	1999-08-10	Canada
4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1995-12-31	2007-08-02	Canada
4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-12-31	2015-08-05	Canada
4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-12-31	2007-08-02	Canada
4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1995-12-31	2007-08-02	Canada
4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-12-31	2015-08-05	Canada
4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1995-12-31	2007-08-02	Canada
4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-12-31	2015-08-05	Canada
4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-12-31	2007-08-02	Canada
4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-12-31	2015-08-05	Canada
4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1995-12-31	2007-08-02	Canada
4.25%trav. Amino Acid InJ.W.O.elect.5%dext.	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Liquid	Intravenous	Clintec Nutrition Company	1996-12-31	1999-08-10	Canada
4.25%travasol Amino Acid InJ.W.elecw.5%dex.	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Liquid	Intravenous	Clintec Nutrition Company	1996-12-31	1999-08-10	Canada
5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-12-31	2015-08-05	Canada
5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-12-31	2015-08-05	Canada
5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-12-31	2007-08-02	Canada
Aminoderm Poudre	Glycine L-Cysteine L-Threonine Neomycin	Powder	Topical	Desbergers LtÉe, Division Of Technilab Inc.	1968-12-31	2004-08-09	Canada
Aminosyn	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Injection, solution	Intravenous	Hospira, Inc.	2012-03-06	Not applicable	US
Aminosyn 10%	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Hospira, Inc.	1979-12-31	Not applicable	Canada
Aminosyn 10% W Electrolytes	Dipotassium phosphate Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Liquid	Intravenous	Abbott	1984-12-31	1999-08-09	Canada
Aminosyn 3.5% M	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium Potassium Sodium Chloride	Liquid	Intravenous	Abbott	1980-12-31	1999-08-09	Canada
Aminosyn 5%	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Hospira, Inc.	1977-12-31	2016-07-29	Canada
Aminosyn 7%	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Hospira, Inc.	1979-12-31	2016-07-29	Canada
Aminosyn 8.5%	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Hospira, Inc.	1984-12-31	2016-07-29	Canada
Aminosyn 8.5% Injection With Electrolytes	Dipotassium phosphate Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium Chloride	Solution	Intravenous	Hospira, Inc.	1984-12-31	2012-08-03	Canada
Aminosyn II	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine	Injection, solution	Intravenous	Hospira, Inc.	1986-04-03	2017-05-18	US
Aminosyn II 10%	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine	Solution	Intravenous	Hospira, Inc.	1987-12-31	Not applicable	Canada
Aminosyn II 10% With Electrolytes	Dipotassium phosphate Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine Magnesium chloride N-acetyltyrosine Potassium Chloride Sodium Chloride	Solution	Intravenous	Hospira, Inc.	1991-12-31	2016-07-29	Canada
Aminosyn II 15%	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine	Solution	Intravenous	Hospira, Inc.	1995-12-31	Not applicable	Canada
Aminosyn II 5% Inj	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine	Liquid	Intravenous	Abbott	1988-12-31	1999-08-09	Canada
Aminosyn II 7% Injection	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine	Solution	Intravenous	Hospira, Inc.	1987-12-31	2016-07-29	Canada
Aminosyn II 7% M In 10% Dextrose(dual Chamber)	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine Magnesium chloride N-acetyltyrosine Potassium Chloride Sodium Chloride Sodium phosphate	Solution	Intravenous	Hospira, Inc.	1987-12-31	2012-08-03	Canada
Aminosyn II 7% With 10% Dextrose	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine	Solution	Intravenous	Hospira, Inc.	1988-12-31	2012-08-03	Canada
Aminosyn II 7% With 50% Dextrose	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine	Solution	Intravenous	Hospira, Inc.	1988-12-31	2012-08-03	Canada
Aminosyn II 8.5% Injection	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine	Solution	Intravenous	Hospira, Inc.	1987-12-31	2016-07-29	Canada
Aminosyn II 8.5% M In 20% Dextrose (dual Chamber)	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine Magnesium chloride N-acetyltyrosine Potassium Chloride Sodium Chloride Sodium phosphate	Solution	Intravenous	Hospira, Inc.	1987-12-31	2012-08-03	Canada
Aminosyn II 8.5% With 50% Dextrose	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine	Solution	Intravenous	Hospira, Inc.	1988-12-31	2012-08-03	Canada
Aminosyn II In Dextrose Injection	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine N-acetyltyrosine	Solution	Intravenous	Hospira, Inc.	1987-12-31	2012-08-03	Canada
Aminosyn II With Electrolytes	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine Magnesium chloride N-acetyltyrosine Potassium Chloride Sodium Chloride Sodium phosphate	Injection, solution	Intravenous	Hospira, Inc.	1986-04-03	Not applicable	US
Aminosyn Sulfite Free	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Injection, solution	Intravenous	Hospira, Inc.	2011-10-27	Not applicable	US
Aminosyn-PF	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Taurine	Injection, solution	Intravenous	Hospira, Inc.	1985-09-06	Not applicable	US
Aminosyn-PF 10%	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Taurine	Solution	Intravenous	Hospira, Inc.	1990-12-31	2016-07-29	Canada
Aminosyn-PF 7%	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Taurine	Solution	Intravenous	Hospira, Inc.	1990-12-31	2016-07-29	Canada
Antacid 2 Tablets	Calcium Carbonate Glycine	Tablet	Oral	Advertising Unlimited Inc. (A.U.I.)	1991-12-31	2010-02-10	Canada
Cicatrin Powder	Bacitracin Glycine L-Cysteine L-Threonine Neomycin	Powder	Topical	Glaxosmithkline Inc	1987-12-31	2009-01-19	Canada
Clinimix	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Injection	Intravenous	Baxter Laboratories	1997-09-29	Not applicable	US
Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec	Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Baxter Corporation Clintec Nutrition Division	1996-12-31	2007-08-02	Canada
Clinimix E	Calcium Chloride Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Injection	Intravenous	Baxter Laboratories	1997-03-26	Not applicable	US
Clinisol	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Injection, solution	Intravenous	Baxter Laboratories	1996-08-30	Not applicable	US
Hepatamine	Glycine L-Alanine L-Arginine L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Valine Phosphoric acid	Injection, solution	Intravenous	B. Braun Medical Inc.	1982-08-03	Not applicable	US
Novamine	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Injection, solution, concentrate	Intravenous	Hospira, Inc.	2011-11-22	Not applicable	US
Olimel 3.3% E	Calcium Chloride Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Olive oil Potassium Chloride Sodium acetate Sodium glycerophosphate Soybean oil	Emulsion	Intravenous	Baxter Laboratories	Not applicable	Not applicable	Canada
Olimel 4.4%	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Olive oil Soybean oil	Emulsion	Intravenous	Baxter Laboratories	2011-09-29	Not applicable	Canada
Olimel 4.4% E	Calcium Chloride Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Olive oil Potassium Chloride Sodium acetate Sodium glycerophosphate Soybean oil	Emulsion	Intravenous	Baxter Laboratories	2011-02-26	Not applicable	Canada
Olimel 5.7%	Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Olive oil Soybean oil	Emulsion	Intravenous	Baxter Laboratories	2011-03-01	Not applicable	Canada
Olimel 5.7% E	Calcium Chloride Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Olive oil Potassium Chloride Sodium acetate Sodium glycerophosphate Soybean oil	Emulsion	Intravenous	Baxter Laboratories	2011-01-19	Not applicable	Canada
Periolimel 2.5% E	Calcium Chloride Glucose Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Olive oil Potassium Chloride Sodium acetate Sodium glycerophosphate Soybean oil	Emulsion	Intravenous	Baxter Laboratories	2011-02-28	Not applicable	Canada
Ph 12 Sterile Diluent for Flolan	Glycine Sodium Chloride Water	Liquid	Intravenous	Glaxosmithkline Inc	2016-08-04	Not applicable	Canada
Plenamine	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	B. Braun Medical Inc.	2015-01-30	Not applicable	US
Premasol - Sulfite-free (amino Acid)	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Taurine	Injection, solution	Intravenous	Baxter Laboratories	2003-06-19	Not applicable	US
Primene 10%	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Ornithine Taurine	Liquid	Intravenous	Baxter Laboratories	1997-11-14	Not applicable	Canada
Primene 10%-liq IV	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Ornithine Taurine	Liquid	Intravenous	Clintec Nutrition Company	1995-12-31	1998-08-13	Canada
Prosol	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Injection, solution	Intravenous	Baxter Laboratories	1998-08-26	Not applicable	US
Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec	Dipotassium phosphate Glucose Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Liquid	Intravenous	Baxter Corporation Clintec Nutrition Division	1993-12-31	2000-07-20	Canada
Renamin (amino Acids) Injection	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Baxter Laboratories	1996-02-02	2011-05-10	Canada
Sterile Diluent for Flolan Injection	Glycine Sodium Chloride Water	Liquid	Intravenous	Glaxosmithkline Inc	1997-07-28	Not applicable	Canada
Travasol	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Injection	Intravenous	Baxter Laboratories	1984-08-23	Not applicable	US
Travasol Amino Acid Inj 5.5%	Dipotassium phosphate Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Laboratories	1981-12-31	2007-08-02	Canada
Travasol Amino Acid Inj 8.5%	Dipotassium phosphate Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Laboratories	1980-12-31	2008-03-26	Canada
Travasol E	Dipotassium phosphate Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium chloride Sodium acetate Sodium Chloride	Solution	Intravenous	Baxter Laboratories	1974-12-31	Not applicable	Canada
Travasol Inj Without Electrolytes 5.5%	Glycine L-Alanine L-Arginine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Baxter Laboratories	1978-12-31	2007-08-02	Canada
Trophamine	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine N-acetyltyrosine Taurine	Solution	Intravenous	B. Braun Medical Inc.	1984-07-20	Not applicable	US
Vamin 18 Electrolyte-free	Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine	Solution	Intravenous	Fresenius Kabi Ab	1996-12-30	2006-07-17	Canada
Vamin N	Calcium Chloride Glutamic Acid Glycine L-Alanine L-Arginine L-Aspartic Acid L-Cysteine L-Histidine L-Isoleucine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Serine L-Threonine L-Tryptophan L-Tyrosine L-Valine Magnesium Sulfate Potassium Chloride Potassium hydroxide Sodium hydroxide	Solution	Intravenous	Fresenius Kabi Ab	1995-12-31	2006-07-17	Canada

Categories

UNII

TE7660XO1C

CAS number

56-40-6

Weight

Average: 75.0666
Monoisotopic: 75.032028409

Chemical Formula

C₂H₅NO₂

InChI Key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

InChI

InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

IUPAC Name

2-aminoacetic acid

SMILES

NCC(O)=O

Pharmacology

Indication

Supplemental glycine may have antispastic activity. Very early findings suggest it may also have antipsychotic activity as well as antioxidant and anti-inflammatory activities.

Structured Indications

Not Available

Pharmacodynamics

Helps trigger the release of oxygen to the energy requiring cell-making process; Important in the manufacturing of hormones responsible for a strong immune system.

Mechanism of action

In the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding site is located on the NMDA receptor complex. The strychnine-sensitive glycine receptor complex is comprised of a chloride channel and is a member of the ligand-gated ion channel superfamily. The putative antispastic activity of supplemental glycine could be mediated by glycine's binding to strychnine-sensitive binding sites in the spinal cord. This would result in increased chloride conductance and consequent enhancement of inhibitory neurotransmission. The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia.
Animal studies indicate that supplemental glycine protects against endotoxin-induced lethality, hypoxia-reperfusion injury after liver transplantation, and D-galactosamine-mediated liver injury. Neutrophils are thought to participate in these pathologic processes via invasion of tissue and releasing such reactive oxygen species as superoxide. In vitro studies have shown that neutrophils contain a glycine-gated chloride channel that can attenuate increases in intracellular calcium and diminsh neutrophil oxidant production. This research is ealy-stage, but suggests that supplementary glycine may turn out to be useful in processes where neutrophil infiltration contributes to toxicity, such as ARDS.

Target	Kind	Pharmacological action	Actions	Organism	UniProt ID
Glutathione synthetase	Protein	unknown	Not Available	Human	P48637	details
Glycine receptor subunit alpha-1	Protein	unknown	Not Available	Human	P23415	details
Serine--pyruvate aminotransferase	Protein	unknown	Not Available	Human	P21549	details
Glycine receptor subunit beta	Protein	unknown	Not Available	Human	P48167	details
Serine hydroxymethyltransferase, cytosolic	Protein	unknown	Not Available	Human	P34896	details
Glycine receptor subunit alpha-3	Protein	unknown	Not Available	Human	O75311	details
Glycine receptor subunit alpha-2	Protein	unknown	Not Available	Human	P23416	details
Glycine N-methyltransferase	Protein	unknown	Not Available	Human	Q14749	details
Glycine amidinotransferase, mitochondrial	Protein	unknown	Not Available	Human	P50440	details
Glutamate receptor ionotropic, NMDA 3B	Protein	unknown	Not Available	Human	O60391	details
Glycine dehydrogenase [decarboxylating], mitochondrial	Protein	unknown	Not Available	Human	P23378	details
Sodium- and chloride-dependent glycine transporter 1	Protein	unknown	Not Available	Human	P48067	details
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	Protein	unknown	Not Available	Human	O75600	details
5-aminolevulinate synthase, nonspecific, mitochondrial	Protein	unknown	Not Available	Human	P13196	details
5-aminolevulinate synthase, erythroid-specific, mitochondrial	Protein	unknown	Not Available	Human	P22557	details
Glycine cleavage system H protein, mitochondrial	Protein	unknown	Not Available	Human	P23434	details
Glycine--tRNA ligase	Protein	unknown	Not Available	Human	P41250	details
Glutamate receptor ionotropic, NMDA 2A	Protein	unknown	antagonist	Human	Q12879	details
Bile acid-CoA:amino acid N-acyltransferase	Protein	unknown	Not Available	Human	Q14032	details
N-arachidonyl glycine receptor	Protein	unknown	Not Available	Human	Q14330	details
Glutamate receptor ionotropic, NMDA 2C	Protein	unknown	Not Available	Human	Q14957	details
Serine hydroxymethyltransferase	Protein	unknown	Not Available	Human	Q53ET4	details
Glycine N-acyltransferase	Protein	unknown	Not Available	Human	Q6IB77	details
Proton-coupled amino acid transporter 1	Protein	unknown	Not Available	Human	Q7Z2H8	details
Serine hydroxymethyltransferase, mitochondrial	Protein	unknown	Not Available	Human	P34897	details
Glycine N-acyltransferase-like protein 2	Protein	unknown	Not Available	Human	Q8WU03	details
Glycine N-acyltransferase-like protein 1	Protein	unknown	Not Available	Human	Q969I3	details
Alanine--glyoxylate aminotransferase 2, mitochondrial	Protein	unknown	Not Available	Human	Q9BYV1	details
Vesicular inhibitory amino acid transporter	Protein	unknown	Not Available	Human	Q9H598	details
Peroxisomal sarcosine oxidase	Protein	unknown	Not Available	Human	Q9P0Z9	details
Sodium- and chloride-dependent glycine transporter 2	Protein	unknown	Not Available	Human	Q9Y345	details

Absorption

Absorbed from the small intestine via an active transport mechanism.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Hepatic

Route of elimination

Not Available

Half life

Not Available

Clearance

Not Available

Toxicity

ORL-RAT LD₅₀ 7930 mg/kg, SCU-RAT LD₅₀ 5200 mg/kg, IVN-RAT LD₅₀ 2600 mg/kg, ORL-MUS LD₅₀ 4920 mg/kg; Doses of 1 gram daily are very well tolerated. Mild gastrointestinal symptoms are infrequently noted. In one study doses of 90 grams daily were also well tole.

Affected organisms

Humans and other mammals

Pathways

Pathway	Category	SMPDB ID
Adenylosuccinate Lyase Deficiency	Disease	SMP00167
Molybdenum Cofactor Deficiency	Disease	SMP00203
Purine Nucleoside Phosphorylase Deficiency	Disease	SMP00210
S-Adenosylhomocysteine (SAH) Hydrolase Deficiency	Disease	SMP00214
Glycine N-methyltransferase Deficiency	Disease	SMP00222
Non Ketotic Hyperglycinemia	Disease	SMP00223
Cerebrotendinous Xanthomatosis (CTX)	Disease	SMP00315
Hereditary Coproporphyria (HCP)	Disease	SMP00342
Primary Hyperoxaluria Type I	Disease	SMP00352
Carnitine Synthesis	Metabolic	SMP00465
Dimethylglycine Dehydrogenase Deficiency	Disease	SMP00484
Adenine phosphoribosyltransferase deficiency (APRT)	Disease	SMP00535
Mitochondrial DNA depletion syndrome	Disease	SMP00536
sarcosine oncometabolite pathway	Disease	SMP02313
Methionine Metabolism	Metabolic	SMP00033
Purine Metabolism	Metabolic	SMP00050
Alanine Metabolism	Metabolic	SMP00055
Glutamate Metabolism	Metabolic	SMP00072
5-Oxoprolinuria	Disease	SMP00143
Adenosine Deaminase Deficiency	Disease	SMP00144
Xanthine Dehydrogenase Deficiency (Xanthinuria)	Disease	SMP00220
Methionine Adenosyltransferase Deficiency	Disease	SMP00221
Lactic Acidemia	Disease	SMP00313
Hypermethioninemia	Disease	SMP00341
Ornithine Aminotransferase Deficiency (OAT Deficiency)	Disease	SMP00363
Homocarnosinosis	Disease	SMP00385
Glycine and Serine Metabolism	Metabolic	SMP00004
Ammonia Recycling	Metabolic	SMP00009
Arginine and Proline Metabolism	Metabolic	SMP00020
Porphyrin Metabolism	Metabolic	SMP00024

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Not Available

Food Interactions

Not Available

References

Synthesis Reference

Koichi Niimura, Takako Kawabe, Takao Ando, Kenichi Saito, "Phenylalanine-glycine compounds having anti-tumor activity, process for preparation thereof, and pharmaceutical composition containing said compounds." U.S. Patent US5411964, issued August, 1908.

US5411964

General References

Not Available

External Links

Resource	Link
Human Metabolome Database (HMDB)	HMDB00123
KEGG Drug	D00011
KEGG Compound	C00037
PubChem Compound	750
PubChem Substance	46508219
ChemSpider	730
BindingDB	18133
ChEBI	15428
ChEMBL	CHEMBL773
Therapeutic Targets Database	DAP000288
PharmGKB	PA449789
IUPHAR	727
Guide to Pharmacology	727
HET	GLY
Drug Product Database	8865
PDRhealth	http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/gly_0127.shtml
Wikipedia	Glycine

ATC Codes

B05CX03 — Glycine

AHFS Codes

40:36.00

PDB Entries

1KL1

FDA label

Not Available

MSDS

Download (72.3 KB)

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Recruiting	Supportive Care	Protein Feeding in Post-traumatic Injury Patients	1
2	Active Not Recruiting	Treatment	Bipolar Disorder (BD) / Schizo-Affective Disorder	1
2	Active Not Recruiting	Treatment	Carcinoid Tumors / Medulloblastomas / Neuroblastomas / Neuroendocrine Tumors	1
2	Completed	Treatment	Alcoholism / Schizophrenic Disorders	1
2	Completed	Treatment	Psychotic Disorder NOS / Schizoaffecitve Disorder / Schizophrenic Disorders	1
2	Completed	Treatment	Schizophrenic Disorders	1
2	Not Yet Recruiting	Prevention	Hypertensive	1
2	Terminated	Prevention	Herpes Labialis / Herpes Simplex Virus	1
2, 3	Completed	Treatment	Schizoaffective Disorders / Schizophrenic Disorders	1
2, 3	Completed	Treatment	Schizophrenia Prodrome	1
3	Completed	Treatment	Critical Illness	1
3	Completed	Treatment	Infant, Low Birth Weight / Infant, Small for Gestational Age / Infants, Premature / Newborn Infants / Sepsis	1
3	Unknown Status	Treatment	Diarrheal Disorder	1
3	Withdrawn	Treatment	Diarrhea, Malnutrition	1
3	Withdrawn	Treatment	Diarrhea, Malnutrition / Other Nutritional Deficiencies	1
3	Withdrawn	Treatment	Schizophrenic Disorders	1
Not Available	Completed	Prevention	Alcohol Dependence / Alcohol Dependent	1
Not Available	Completed	Treatment	Obsessive Compulsive Disorder (OCD)	1

Pharmacoeconomics

Manufacturers

Baxter healthcare corp
B braun medical inc
Hospira inc

Packagers

Dosage forms

Form	Route	Strength
Powder	Topical
Injection, solution	Intravenous
Tablet	Oral
Irrigant	Irrigation	1.5 g/100mL
Solution	Irrigation	1.5 g/100mL
Solution	Irrigation	15 mg
Liquid	Irrigation	1.5 g
Liquid	Irrigation	1.5 %
Injection, solution, concentrate	Intravenous
Emulsion	Intravenous
Solution	Intravenous
Liquid	Intravenous
Injection	Intravenous

Prices

Unit description	Cost	Unit
Diluent for flolan vial	0.31USD	ml
Amino acetic acid powder	0.03USD	g
Glycine powder	0.03USD	g
Glycine 1.5% irrigation	0.02USD	ml

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Not Available

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	262 dec °C	PhysProp
water solubility	2.49E+005 mg/L (at 25 °C)	YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP	-3.21	HANSCH,C ET AL. (1995)
pKa	2.37 (at 20 °C)	KORTUM,G ET AL (1961)

Predicted Properties

Property	Value	Source
Water Solubility	552.0 mg/mL	ALOGPS
logP	-3.3	ALOGPS
logP	-3.4	ChemAxon
logS	0.87	ALOGPS
pKa (Strongest Acidic)	2.31	ChemAxon
pKa (Strongest Basic)	9.24	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	63.32 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	16 m³·mol^-1	ChemAxon
Polarizability	6.65 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9156
Blood Brain Barrier	+	0.5728
Caco-2 permeable	-	0.7533
P-glycoprotein substrate	Non-substrate	0.7821
P-glycoprotein inhibitor I	Non-inhibitor	0.9841
P-glycoprotein inhibitor II	Non-inhibitor	0.9794
Renal organic cation transporter	Non-inhibitor	0.9436
CYP450 2C9 substrate	Non-substrate	0.8833
CYP450 2D6 substrate	Non-substrate	0.8526
CYP450 3A4 substrate	Non-substrate	0.8432
CYP450 1A2 substrate	Non-inhibitor	0.9628
CYP450 2C9 inhibitor	Non-inhibitor	0.9738
CYP450 2D6 inhibitor	Non-inhibitor	0.975
CYP450 2C19 inhibitor	Non-inhibitor	0.973
CYP450 3A4 inhibitor	Non-inhibitor	0.9405
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9871
Ames test	Non AMES toxic	0.9133
Carcinogenicity	Non-carcinogens	0.6261
Biodegradation	Ready biodegradable	0.9289
Rat acute toxicity	1.0076 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9611
hERG inhibition (predictor II)	Non-inhibitor	0.9556

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)

Download (6.91 KB)

Spectra

Spectrum Type	Description	Splash Key
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-00dj-2900000000-0ef96bcf06ce475afcdd	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)	splash10-00dj-1900000000-1d289099ac79cfb8bb19	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-00di-7910000000-6c972a683dfb75b69331	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (2 TMS)	splash10-0udi-0900000000-ef69e38ee6cebc2ece00	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (3 TMS)	splash10-00di-2910000000-3215b9e40f20c7b306cd	View in MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS	Not Available
GC-MS	GC-MS Spectrum - EI-B	splash10-001i-9000000000-719b7f248956f13a312d	View in MoNA
GC-MS	GC-MS Spectrum - EI-B	splash10-0udi-0900000000-99b4fc43740b21edc786	View in MoNA
GC-MS	GC-MS Spectrum - EI-B	splash10-00di-1910000000-4cff4d14c73acff9442f	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-QQ	splash10-0002-4960000000-2c6fa028e985c6019854	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF	splash10-00ds-2900000000-ffffed9c78c16a884e4a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-003r-9000000000-725357e461c898a7451e	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-001i-9000000000-9f3930e66b117ad91dca	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-001i-9000000000-b3336097dddbb5e22871	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - EI-B (HITACHI RMU-6M) , Positive	splash10-001i-9000000000-719b7f248956f13a312d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-00di-9000000000-6001578fc511ba3fefef	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-00di-9000000000-79b2a0a9d93de6a62358	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-00di-9000000000-9290dbe208c4744f4431	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-004i-9000000000-342ab462db0835abb3d2	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-0ar1-9010000000-9daadc1d169a8530926d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-07y0-9220000000-8c7785f1f3aa8052679f	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-0ula-9110000000-43ada06fe1b56b4e9fcc	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-017i-9000000000-fbd78fbb48f082235f42	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , Positive	splash10-004i-9000000000-c38d0fb28793438083a9	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-TOF , negative	splash10-00di-9000000000-605b44ac311a9af4bb7a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - DI-ESI-Q-Exactive Plus , Positive	Not Available
LC-MS/MS	LC-MS/MS Spectrum - DI-ESI-Q-Exactive Plus , Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0059-9000000000-c6b1ebc1dba89b6a6184	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-001i-9000000000-851aa6a0263541a8b249	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-053r-9000000000-d3b5624412082bb2cf60	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00di-9000000000-89b2c043a5afe3ebc6f6	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-00di-9000000000-b4046e208ee8adb87021	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-05fr-9000000000-36521e440c602bd2ca5a	View in MoNA
MS	Mass Spectrum (Electron Ionization)	splash10-001i-9000000000-222d6c3a1ba6afcd7ea9	View in MoNA
1D NMR	1H NMR Spectrum	Not Available
1D NMR	13C NMR Spectrum	Not Available
1D NMR	1H NMR Spectrum	Not Available
1D NMR	13C NMR Spectrum	Not Available
1D NMR	1H NMR Spectrum	Not Available
2D NMR	[1H,1H] 2D NMR Spectrum	Not Available
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available

Taxonomy

Description

This compound belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Alpha amino acids

Alternative Parents

Amino acids / Monocarboxylic acids and derivatives / Carboxylic acids / Organopnictogen compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives / Carbonyl compounds

Substituents

Alpha-amino acid / Amino acid / Carboxylic acid / Monocarboxylic acid or derivatives / Organic nitrogen compound / Organic oxide / Hydrocarbon derivative / Primary amine / Organooxygen compound / Organonitrogen compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

alpha-amino acid, proteinogenic amino acid, serine family amino acid (CHEBI:15428 ) / Common amino acids, Amino acids (C00037 )

Structure for DB00145 (Glycine)

Targets

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