Identification

Name
Lumiracoxib
Accession Number
DB01283
Type
Small Molecule
Groups
Approved, Investigational
Description

Lumiracoxib is a COX-2 selective inhibitor non-steroidal anti-inflammatory drug. On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver failure. New Zealand and Canada have also followed suit in recalling the drug.

Structure
Thumb
Synonyms
  • 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid
  • Lumiracoxibum
External IDs
COX 189 / COX-189 / COX189
International/Other Brands
Prexige (Novartis)
Categories
UNII
V91T9204HU
CAS number
220991-20-8
Weight
Average: 293.721
Monoisotopic: 293.061884577
Chemical Formula
C15H13ClFNO2
InChI Key
KHPKQFYUPIUARC-UHFFFAOYSA-N
InChI
InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20)
IUPAC Name
2-{2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
SMILES
CC1=CC=C(NC2=C(Cl)C=CC=C2F)C(CC(O)=O)=C1

Pharmacology

Indication

For the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults.

Pharmacodynamics

Lumiracoxib has a different structure from the standard COX-2 inhibitors (e.g. celecoxib). It more closely resembles the structure of diclofenac (one chlorine substituted by fluorine, the phenylacetic acid has another methyl group in meta position), making it a member of the arylalkanoic acid family of NSAIDs. It binds to a different site on the COX-2 receptor than the standard COX-2 inhibitors. It displays extremely high COX-2 selectivity.

Mechanism of action

The mechanism of action of lumiracoxib is due to inhibition of prostaglandin synthesis via inhibition of cyclooygenase-2 (COX-2). Lumiracoxib does not inhibit COX-1 at therapeutic concentrations.

TargetActionsOrganism
AProstaglandin G/H synthase 2
inhibitor
Human
AProstaglandin G/H synthase 1
inhibitor
Human
Absorption

Rapidly absorbed following oral administration, with an absolute oral bioavailablity of 74%.

Volume of distribution
Not Available
Protein binding

Highly bound to plasma proteins (>= 98%).

Metabolism

Hepatic oxidation and hydroxylation via CYP2C9. Three major metabolites have been identified in plasma: 4'-hydroxy-lumiracoxib, 5-carboxy-lumiracoxib, and 4'-hydroxy-5-carboxy-lumiracoxib.

Route of elimination
Not Available
Half life

Terminal half-life is approximately 4 hours.

Clearance
Not Available
Toxicity

Single oral doses in mice and rats resulted in mortality and/or moribundity at doses of 600 mg/kg and 500 mg/kg, respectively. Single intraperitoneal doses in mice and rats results in mortality/moribundity at 750 mg/kg and 1000 mg/kg, respectively. The maximum non-lethal single oral and intraperitoneal dose in mouse was 300 mg/kg and 250 mg/kg, respectively. In the rat it was 150 mg/kg and 250 mg/kg, respectively.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Lumiracoxib Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limoneneThe risk or severity of adverse effects can be increased when (4R)-limonene is combined with Lumiracoxib.Investigational
16-BromoepiandrosteroneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with 16-Bromoepiandrosterone.Investigational
19-norandrostenedioneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with 19-norandrostenedione.Experimental, Illicit
5-androstenedioneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with 5-androstenedione.Experimental, Illicit
AbciximabLumiracoxib may increase the anticoagulant activities of Abciximab.Approved
AbirateroneThe serum concentration of Lumiracoxib can be increased when it is combined with Abiraterone.Approved
AcebutololLumiracoxib may decrease the antihypertensive activities of Acebutolol.Approved, Investigational
AceclofenacThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Aceclofenac.Approved, Investigational
AcemetacinThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolLumiracoxib may increase the anticoagulant activities of Acenocoumarol.Approved, Investigational
AcetaminophenThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Acetaminophen.Approved
Acetyl sulfisoxazoleThe metabolism of Lumiracoxib can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Lumiracoxib.Approved, Vet Approved
AdapaleneThe risk or severity of adverse effects can be increased when Adapalene is combined with Lumiracoxib.Approved
AlaproclateAlaproclate may increase the antiplatelet activities of Lumiracoxib.Experimental
AlclofenacThe risk or severity of adverse effects can be increased when Alclofenac is combined with Lumiracoxib.Approved, Withdrawn
AlclometasoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Alclometasone.Approved
AldosteroneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Aldosterone.Experimental, Investigational
Alendronic acidThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Alendronic acid.Approved
AliskirenLumiracoxib may decrease the antihypertensive activities of Aliskiren.Approved, Investigational
AlminoprofenThe risk or severity of adverse effects can be increased when Alminoprofen is combined with Lumiracoxib.Experimental
AlprenololLumiracoxib may decrease the antihypertensive activities of Alprenolol.Approved, Withdrawn
AlprostadilThe therapeutic efficacy of Alprostadil can be decreased when used in combination with Lumiracoxib.Approved, Investigational
AmcinonideThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Amcinonide.Approved
AmikacinLumiracoxib may decrease the excretion rate of Amikacin which could result in a higher serum level.Approved, Investigational, Vet Approved
AmilorideLumiracoxib may decrease the antihypertensive activities of Amiloride.Approved
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Aminosalicylic Acid.Approved
AmiodaroneThe metabolism of Lumiracoxib can be decreased when combined with Amiodarone.Approved, Investigational
AncrodLumiracoxib may increase the anticoagulant activities of Ancrod.Approved, Investigational
AndrographolideThe risk or severity of adverse effects can be increased when Andrographolide is combined with Lumiracoxib.Investigational
AndrostenedioneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Androstenedione.Experimental, Illicit
AnecortaveThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Anecortave.Investigational
anecortave acetateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with anecortave acetate.Investigational
AnisodamineThe risk or severity of adverse effects can be increased when Anisodamine is combined with Lumiracoxib.Investigational
AntipyrineThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Antipyrine.Approved, Investigational
Antithrombin III humanLumiracoxib may increase the anticoagulant activities of Antithrombin III human.Approved
AntrafenineThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Antrafenine.Approved
ApalutamideThe serum concentration of Lumiracoxib can be decreased when it is combined with Apalutamide.Approved, Investigational
ApixabanLumiracoxib may increase the anticoagulant activities of Apixaban.Approved
ApocyninThe risk or severity of adverse effects can be increased when Apocynin is combined with Lumiracoxib.Investigational
ApramycinLumiracoxib may decrease the excretion rate of Apramycin which could result in a higher serum level.Experimental, Vet Approved
ApremilastThe risk or severity of adverse effects can be increased when Apremilast is combined with Lumiracoxib.Approved, Investigational
AprepitantThe metabolism of Lumiracoxib can be increased when combined with Aprepitant.Approved, Investigational
ArbekacinLumiracoxib may decrease the excretion rate of Arbekacin which could result in a higher serum level.Approved, Investigational
ArdeparinLumiracoxib may increase the anticoagulant activities of Ardeparin.Approved, Investigational, Withdrawn
ArgatrobanLumiracoxib may increase the anticoagulant activities of Argatroban.Approved, Investigational
ArmodafinilThe metabolism of Lumiracoxib can be decreased when combined with Armodafinil.Approved, Investigational
ArotinololLumiracoxib may decrease the antihypertensive activities of Arotinolol.Investigational
AsenapineLumiracoxib may decrease the antihypertensive activities of Asenapine.Approved
AtamestaneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Atamestane.Investigational
AtenololLumiracoxib may decrease the antihypertensive activities of Atenolol.Approved
AzapropazoneThe risk or severity of adverse effects can be increased when Azapropazone is combined with Lumiracoxib.Withdrawn
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Lumiracoxib.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Azficel-T.Approved, Investigational
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Lumiracoxib.Approved, Investigational
AzithromycinThe metabolism of Lumiracoxib can be decreased when combined with Azithromycin.Approved
AzosemideThe therapeutic efficacy of Azosemide can be decreased when used in combination with Lumiracoxib.Investigational
BalsalazideThe risk or severity of adverse effects can be increased when Balsalazide is combined with Lumiracoxib.Approved, Investigational
BazedoxifeneLumiracoxib may increase the thrombogenic activities of Bazedoxifene.Approved, Investigational
BecaplerminLumiracoxib may increase the anticoagulant activities of Becaplermin.Approved, Investigational
Beclomethasone dipropionateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Beclomethasone dipropionate.Approved, Investigational
BefunololLumiracoxib may decrease the antihypertensive activities of Befunolol.Experimental
BekanamycinLumiracoxib may decrease the excretion rate of Bekanamycin which could result in a higher serum level.Experimental
BenazeprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Benazepril.Approved, Investigational
BendazacThe risk or severity of adverse effects can be increased when Bendazac is combined with Lumiracoxib.Experimental
BendroflumethiazideThe therapeutic efficacy of Bendroflumethiazide can be decreased when used in combination with Lumiracoxib.Approved
BenorilateThe risk or severity of adverse effects can be increased when Benorilate is combined with Lumiracoxib.Experimental
BenoxaprofenThe risk or severity of adverse effects can be increased when Benoxaprofen is combined with Lumiracoxib.Withdrawn
BenzthiazideThe therapeutic efficacy of Benzthiazide can be decreased when used in combination with Lumiracoxib.Approved
BenzydamineThe risk or severity of adverse effects can be increased when Benzydamine is combined with Lumiracoxib.Approved
BeraprostThe therapeutic efficacy of Beraprost can be decreased when used in combination with Lumiracoxib.Investigational
BetamethasoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Betamethasone.Approved, Vet Approved
BetaxololLumiracoxib may decrease the antihypertensive activities of Betaxolol.Approved, Investigational
BetrixabanThe risk or severity of bleeding can be increased when Betrixaban is combined with Lumiracoxib.Approved, Investigational
BevantololLumiracoxib may decrease the antihypertensive activities of Bevantolol.Approved
BevoniumThe risk or severity of adverse effects can be increased when Bevonium is combined with Lumiracoxib.Experimental
BimatoprostThe therapeutic efficacy of Bimatoprost can be decreased when used in combination with Lumiracoxib.Approved, Investigational
BisoprololLumiracoxib may decrease the antihypertensive activities of Bisoprolol.Approved
BivalirudinLumiracoxib may increase the anticoagulant activities of Bivalirudin.Approved, Investigational
BopindololLumiracoxib may decrease the antihypertensive activities of Bopindolol.Approved
BortezomibThe metabolism of Lumiracoxib can be decreased when combined with Bortezomib.Approved, Investigational
BromfenacThe risk or severity of adverse effects can be increased when Bromfenac is combined with Lumiracoxib.Approved
BucillamineThe risk or severity of adverse effects can be increased when Bucillamine is combined with Lumiracoxib.Investigational
BucindololLumiracoxib may decrease the antihypertensive activities of Bucindolol.Investigational
BudesonideThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Budesonide.Approved
BufexamacThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Bufexamac.Approved, Experimental
BufuralolLumiracoxib may decrease the antihypertensive activities of Bufuralol.Experimental, Investigational
BumadizoneThe risk or severity of adverse effects can be increased when Bumadizone is combined with Lumiracoxib.Experimental
BumetanideThe therapeutic efficacy of Bumetanide can be decreased when used in combination with Lumiracoxib.Approved
BupranololLumiracoxib may decrease the antihypertensive activities of Bupranolol.Approved
CaffeineThe metabolism of Lumiracoxib can be decreased when combined with Caffeine.Approved
CandesartanThe risk or severity of adverse effects can be increased when Candesartan is combined with Lumiracoxib.Experimental
Candesartan cilexetilThe risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Lumiracoxib.Approved
CandoxatrilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Candoxatril.Experimental
CapecitabineThe metabolism of Lumiracoxib can be decreased when combined with Capecitabine.Approved, Investigational
CapsaicinThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Capsaicin.Approved
CaptoprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Captopril.Approved
CarbamazepineThe metabolism of Lumiracoxib can be increased when combined with Carbamazepine.Approved, Investigational
Carbaspirin calciumThe risk or severity of adverse effects can be increased when Carbaspirin calcium is combined with Lumiracoxib.Experimental, Investigational
Carboprost TromethamineThe therapeutic efficacy of Carboprost Tromethamine can be decreased when used in combination with Lumiracoxib.Approved
CarprofenThe risk or severity of adverse effects can be increased when Carprofen is combined with Lumiracoxib.Approved, Vet Approved, Withdrawn
CarteololLumiracoxib may decrease the antihypertensive activities of Carteolol.Approved
CarvedilolLumiracoxib may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
CastanospermineThe risk or severity of adverse effects can be increased when Castanospermine is combined with Lumiracoxib.Experimental
CelecoxibThe risk or severity of adverse effects can be increased when Celecoxib is combined with Lumiracoxib.Approved, Investigational
CeliprololLumiracoxib may decrease the antihypertensive activities of Celiprolol.Approved, Investigational
CeritinibThe serum concentration of Lumiracoxib can be increased when it is combined with Ceritinib.Approved
CertoparinLumiracoxib may increase the anticoagulant activities of Certoparin.Approved, Investigational
ChloramphenicolThe metabolism of Lumiracoxib can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChloroquineThe risk or severity of adverse effects can be increased when Chloroquine is combined with Lumiracoxib.Approved, Investigational, Vet Approved
ChlorothiazideThe therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Lumiracoxib.Approved, Vet Approved
ChlorotrianiseneLumiracoxib may increase the thrombogenic activities of Chlorotrianisene.Investigational, Withdrawn
ChlorphenesinThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Chlorphenesin.Approved, Vet Approved, Withdrawn
ChlorthalidoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Lumiracoxib.Approved
CholecalciferolThe metabolism of Lumiracoxib can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CholestyramineCholestyramine can cause a decrease in the absorption of Lumiracoxib resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Choline magnesium trisalicylateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Choline magnesium trisalicylate.Approved
CiclesonideThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Ciclesonide.Approved, Investigational
CilazaprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Cilazapril.Approved
CimetidineThe metabolism of Lumiracoxib can be decreased when combined with Cimetidine.Approved, Investigational
CimicoxibThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Cimicoxib.Investigational
CinoxacinLumiracoxib may increase the neuroexcitatory activities of Cinoxacin.Approved, Investigational, Withdrawn
CiprofloxacinLumiracoxib may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
CisplatinThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Cisplatin.Approved
CitalopramCitalopram may increase the antiplatelet activities of Lumiracoxib.Approved
Citric AcidLumiracoxib may increase the anticoagulant activities of Citric Acid.Approved, Nutraceutical, Vet Approved
ClobetasolThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Clobetasol.Approved, Investigational
Clobetasol propionateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Clobetasol propionate.Approved
ClobetasoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Clobetasone.Approved
ClocortoloneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Clocortolone.Approved
Clodronic AcidThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Clodronic Acid.Approved, Investigational, Vet Approved
ClonixinThe risk or severity of adverse effects can be increased when Clonixin is combined with Lumiracoxib.Approved
CloprostenolThe therapeutic efficacy of Cloprostenol can be decreased when used in combination with Lumiracoxib.Vet Approved
CloranololLumiracoxib may decrease the antihypertensive activities of Cloranolol.Experimental
ClorindioneLumiracoxib may increase the anticoagulant activities of Clorindione.Experimental
ClotrimazoleThe metabolism of Lumiracoxib can be decreased when combined with Clotrimazole.Approved, Vet Approved
ColesevelamColesevelam can cause a decrease in the absorption of Lumiracoxib resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Lumiracoxib resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Conjugated estrogensLumiracoxib may increase the thrombogenic activities of Conjugated estrogens.Approved
Cortexolone 17α-propionateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Cortexolone 17α-propionate.Investigational
CorticosteroneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Corticosterone.Experimental
Cortisone acetateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Cortisone acetate.Approved, Investigational
CrisaboroleThe metabolism of Lumiracoxib can be decreased when combined with Crisaborole.Approved, Investigational
CurcuminThe risk or severity of adverse effects can be increased when Curcumin is combined with Lumiracoxib.Approved, Investigational
CyclopenthiazideThe therapeutic efficacy of Cyclopenthiazide can be decreased when used in combination with Lumiracoxib.Experimental
CyclosporineLumiracoxib may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Lumiracoxib can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
Dabigatran etexilateLumiracoxib may increase the anticoagulant activities of Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Lumiracoxib can be decreased when it is combined with Dabrafenib.Approved, Investigational
DaidzeinLumiracoxib may increase the thrombogenic activities of Daidzein.Experimental
DalteparinLumiracoxib may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidLumiracoxib may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DapoxetineDapoxetine may increase the antiplatelet activities of Lumiracoxib.Investigational
DarexabanLumiracoxib may increase the anticoagulant activities of Darexaban.Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Deferasirox.Approved, Investigational
DeflazacortThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Deflazacort.Approved, Investigational
DelaprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Delapril.Experimental
DelavirdineThe metabolism of Lumiracoxib can be decreased when combined with Delavirdine.Approved
DesipramineLumiracoxib may decrease the antihypertensive activities of Desipramine.Approved, Investigational
DesirudinLumiracoxib may increase the anticoagulant activities of Desirudin.Approved
DesmopressinThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Desmopressin.Approved
DesonideThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Desonide.Approved, Investigational
DesoximetasoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Desoximetasone.Approved
Desoxycorticosterone acetateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Desoxycorticosterone acetate.Approved
Desoxycorticosterone PivalateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Desoxycorticosterone Pivalate.Experimental, Vet Approved
DesvenlafaxineDesvenlafaxine may increase the antiplatelet activities of Lumiracoxib.Approved, Investigational
DexamethasoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Dexamethasone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Dexamethasone isonicotinate.Vet Approved
DexibuprofenThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Dexibuprofen.Approved, Investigational
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Lumiracoxib.Approved, Investigational
DextranLumiracoxib may increase the anticoagulant activities of Dextran.Approved, Investigational, Vet Approved
DibekacinLumiracoxib may decrease the excretion rate of Dibekacin which could result in a higher serum level.Experimental
Dibotermin alfaThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Dibotermin alfa.Approved, Investigational
DiclofenacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Lumiracoxib.Approved, Vet Approved
DicoumarolLumiracoxib may increase the anticoagulant activities of Dicoumarol.Approved
DienestrolLumiracoxib may increase the thrombogenic activities of Dienestrol.Approved, Investigational
DiethylstilbestrolLumiracoxib may increase the thrombogenic activities of Diethylstilbestrol.Approved, Investigational
DifenpiramideThe risk or severity of adverse effects can be increased when Difenpiramide is combined with Lumiracoxib.Experimental
DiflorasoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Diflorasone.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Diflunisal is combined with Lumiracoxib.Approved, Investigational
DifluocortoloneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Difluocortolone.Approved, Investigational, Withdrawn
DifluprednateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Difluprednate.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Lumiracoxib.Approved
DihydrostreptomycinLumiracoxib may decrease the excretion rate of Dihydrostreptomycin which could result in a higher serum level.Investigational, Vet Approved
DinoprostThe therapeutic efficacy of Dinoprost can be decreased when used in combination with Lumiracoxib.Investigational
Dinoprost TromethamineThe therapeutic efficacy of Dinoprost Tromethamine can be decreased when used in combination with Lumiracoxib.Approved, Vet Approved
DinoprostoneThe therapeutic efficacy of Dinoprostone can be decreased when used in combination with Lumiracoxib.Approved
DiphenadioneLumiracoxib may increase the anticoagulant activities of Diphenadione.Experimental
DosulepinThe metabolism of Lumiracoxib can be decreased when combined with Dosulepin.Approved
DrospirenoneLumiracoxib may increase the hyperkalemic activities of Drospirenone.Approved
DroxicamThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Droxicam.Withdrawn
DuloxetineDuloxetine may increase the antiplatelet activities of Lumiracoxib.Approved
DuvelisibThe risk or severity of adverse effects can be increased when Duvelisib is combined with Lumiracoxib.Investigational
E-6201The risk or severity of adverse effects can be increased when E-6201 is combined with Lumiracoxib.Investigational
Edetic AcidLumiracoxib may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanLumiracoxib may increase the anticoagulant activities of Edoxaban.Approved
EfavirenzThe metabolism of Lumiracoxib can be decreased when combined with Efavirenz.Approved, Investigational
EnalaprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Enalaprilat.Approved
EnoxacinLumiracoxib may increase the neuroexcitatory activities of Enoxacin.Approved, Investigational
EnoxaparinLumiracoxib may increase the anticoagulant activities of Enoxaparin.Approved
EnprostilThe therapeutic efficacy of Enprostil can be decreased when used in combination with Lumiracoxib.Experimental
EpanololLumiracoxib may decrease the antihypertensive activities of Epanolol.Experimental
EpimestrolLumiracoxib may increase the thrombogenic activities of Epimestrol.Experimental
EpirizoleThe risk or severity of adverse effects can be increased when Epirizole is combined with Lumiracoxib.Approved
EpitizideThe therapeutic efficacy of Epitizide can be decreased when used in combination with Lumiracoxib.Experimental
EplerenoneLumiracoxib may decrease the antihypertensive activities of Eplerenone.Approved
EpoprostenolThe therapeutic efficacy of Epoprostenol can be decreased when used in combination with Lumiracoxib.Approved
EprosartanThe risk or severity of adverse effects can be increased when Eprosartan is combined with Lumiracoxib.Approved
EquileninThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Equilenin.Experimental
EquilinThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Equilin.Approved
EquolLumiracoxib may increase the thrombogenic activities of Equol.Investigational
EsatenololLumiracoxib may decrease the antihypertensive activities of Esatenolol.Experimental
EscitalopramEscitalopram may increase the antiplatelet activities of Lumiracoxib.Approved, Investigational
Eslicarbazepine acetateThe metabolism of Lumiracoxib can be decreased when combined with Eslicarbazepine acetate.Approved
EsmololLumiracoxib may decrease the antihypertensive activities of Esmolol.Approved
EsomeprazoleThe metabolism of Lumiracoxib can be decreased when combined with Esomeprazole.Approved, Investigational
EstradiolLumiracoxib may increase the thrombogenic activities of Estradiol.Approved, Investigational, Vet Approved
Estradiol acetateLumiracoxib may increase the thrombogenic activities of Estradiol acetate.Approved, Investigational, Vet Approved
Estradiol cypionateLumiracoxib may increase the thrombogenic activities of Estradiol cypionate.Approved, Investigational, Vet Approved
Estradiol valerateLumiracoxib may increase the thrombogenic activities of Estradiol valerate.Approved, Investigational, Vet Approved
EstriolLumiracoxib may increase the thrombogenic activities of Estriol.Approved, Investigational, Vet Approved
Estrogens, esterifiedLumiracoxib may increase the thrombogenic activities of Estrogens, esterified.Approved
EstroneLumiracoxib may increase the thrombogenic activities of Estrone.Approved
Estrone sulfateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Estrone sulfate.Approved
Etacrynic acidThe therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Lumiracoxib.Approved, Investigational
EtanerceptThe risk or severity of adverse effects can be increased when Etanercept is combined with Lumiracoxib.Approved, Investigational
EthenzamideThe risk or severity of adverse effects can be increased when Ethenzamide is combined with Lumiracoxib.Experimental
Ethinyl EstradiolLumiracoxib may increase the thrombogenic activities of Ethinyl Estradiol.Approved
Ethyl biscoumacetateLumiracoxib may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Etidronic acidThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Etidronic acid.Approved
EtodolacThe risk or severity of adverse effects can be increased when Etodolac is combined with Lumiracoxib.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Etofenamate is combined with Lumiracoxib.Approved, Investigational
EtoperidoneEtoperidone may increase the antiplatelet activities of Lumiracoxib.Withdrawn
EtoricoxibThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Etoricoxib.Approved, Investigational
EtravirineThe metabolism of Lumiracoxib can be decreased when combined with Etravirine.Approved
Evening primrose oilThe risk or severity of adverse effects can be increased when Evening primrose oil is combined with Lumiracoxib.Investigational, Nutraceutical
ExisulindThe risk or severity of adverse effects can be increased when Exisulind is combined with Lumiracoxib.Investigational
FelbinacThe risk or severity of adverse effects can be increased when Felbinac is combined with Lumiracoxib.Experimental
FenbufenThe risk or severity of adverse effects can be increased when Fenbufen is combined with Lumiracoxib.Approved
FenoprofenThe risk or severity of adverse effects can be increased when Fenoprofen is combined with Lumiracoxib.Approved
FenprostaleneThe therapeutic efficacy of Fenprostalene can be decreased when used in combination with Lumiracoxib.Vet Approved
FentiazacThe risk or severity of adverse effects can be increased when Fentiazac is combined with Lumiracoxib.Experimental
FeprazoneThe risk or severity of adverse effects can be increased when Feprazone is combined with Lumiracoxib.Experimental
Ferulic acidThe risk or severity of adverse effects can be increased when Ferulic acid is combined with Lumiracoxib.Experimental
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Lumiracoxib.Approved, Investigational
Fish oilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fish oil.Approved, Nutraceutical
FleroxacinLumiracoxib may increase the neuroexcitatory activities of Fleroxacin.Approved
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Lumiracoxib.Approved, Withdrawn
FloxuridineThe metabolism of Lumiracoxib can be decreased when combined with Floxuridine.Approved
FluasteroneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluasterone.Investigational
FluconazoleThe metabolism of Lumiracoxib can be decreased when combined with Fluconazole.Approved, Investigational
FludrocortisoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fludrocortisone.Approved, Investigational
FluindioneLumiracoxib may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlumequineLumiracoxib may increase the neuroexcitatory activities of Flumequine.Withdrawn
FlumethasoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Flumethasone.Approved, Vet Approved
FlunisolideThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Flunisolide.Approved, Investigational
FlunixinThe risk or severity of adverse effects can be increased when Flunixin is combined with Lumiracoxib.Vet Approved
FlunoxaprofenThe risk or severity of adverse effects can be increased when Flunoxaprofen is combined with Lumiracoxib.Experimental
Fluocinolone AcetonideThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluocinolone Acetonide.Approved, Investigational, Vet Approved
FluocinonideThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluocinonide.Approved, Investigational
FluocortoloneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluocortolone.Approved, Withdrawn
FluorometholoneThe risk or severity of adverse effects can be increased when Fluorometholone is combined with Lumiracoxib.Approved, Investigational
FluorouracilThe metabolism of Lumiracoxib can be decreased when combined with Fluorouracil.Approved
FluoxetineFluoxetine may increase the antiplatelet activities of Lumiracoxib.Approved, Vet Approved
FluprednideneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluprednidene.Approved, Withdrawn
FluprednisoloneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluprednisolone.Approved
FluprostenolThe therapeutic efficacy of Fluprostenol can be decreased when used in combination with Lumiracoxib.Vet Approved
FlurandrenolideThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Flurandrenolide.Approved
FlurbiprofenThe risk or severity of adverse effects can be increased when Flurbiprofen is combined with Lumiracoxib.Approved, Investigational
FluticasoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluticasone.Approved, Experimental, Investigational
Fluticasone furoateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluticasone furoate.Approved
Fluticasone propionateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fluticasone propionate.Approved
FluvastatinThe metabolism of Lumiracoxib can be decreased when combined with Fluvastatin.Approved
FluvoxamineThe metabolism of Lumiracoxib can be decreased when combined with Fluvoxamine.Approved, Investigational
Folic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Lumiracoxib.Approved, Nutraceutical, Vet Approved
FondaparinuxLumiracoxib may increase the anticoagulant activities of Fondaparinux.Approved, Investigational
Fondaparinux sodiumLumiracoxib may increase the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
ForasartanThe risk or severity of adverse effects can be increased when Forasartan is combined with Lumiracoxib.Experimental
FormestaneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Formestane.Approved, Investigational, Withdrawn
FosinoprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Fosinopril.Approved
FosphenytoinThe metabolism of Lumiracoxib can be increased when combined with Fosphenytoin.Approved, Investigational
FramycetinLumiracoxib may decrease the excretion rate of Framycetin which could result in a higher serum level.Approved
FurosemideThe therapeutic efficacy of Furosemide can be decreased when used in combination with Lumiracoxib.Approved, Vet Approved
GabexateLumiracoxib may increase the anticoagulant activities of Gabexate.Investigational
GarenoxacinLumiracoxib may increase the neuroexcitatory activities of Garenoxacin.Investigational
GatifloxacinLumiracoxib may increase the neuroexcitatory activities of Gatifloxacin.Approved, Investigational
GemeprostThe therapeutic efficacy of Gemeprost can be decreased when used in combination with Lumiracoxib.Approved, Withdrawn
GemfibrozilThe metabolism of Lumiracoxib can be decreased when combined with Gemfibrozil.Approved
GemifloxacinLumiracoxib may increase the neuroexcitatory activities of Gemifloxacin.Approved, Investigational
GeneticinLumiracoxib may decrease the excretion rate of Geneticin which could result in a higher serum level.Experimental
GenisteinLumiracoxib may increase the thrombogenic activities of Genistein.Investigational
GentamicinLumiracoxib may decrease the excretion rate of Gentamicin which could result in a higher serum level.Approved, Vet Approved
GENTAMICIN C1ALumiracoxib may decrease the excretion rate of GENTAMICIN C1A which could result in a higher serum level.Experimental
GinsengThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Ginseng.Approved, Investigational, Nutraceutical
GrepafloxacinLumiracoxib may increase the neuroexcitatory activities of Grepafloxacin.Approved, Investigational, Withdrawn
GuacetisalThe risk or severity of adverse effects can be increased when Guacetisal is combined with Lumiracoxib.Experimental
HalcinonideThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Halcinonide.Approved, Investigational, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Haloperidol.Approved
HE3286The risk or severity of adverse effects can be increased when Lumiracoxib is combined with HE3286.Investigational
HeparinLumiracoxib may increase the anticoagulant activities of Heparin.Approved, Investigational
HexestrolLumiracoxib may increase the thrombogenic activities of Hexestrol.Withdrawn
HigenamineThe risk or severity of adverse effects can be increased when Higenamine is combined with Lumiracoxib.Investigational
HydralazineLumiracoxib may decrease the antihypertensive activities of Hydralazine.Approved
HydrochlorothiazideThe therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Lumiracoxib.Approved, Vet Approved
HydrocortisoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Hydrocortisone.Approved, Vet Approved
HydroflumethiazideThe therapeutic efficacy of Hydroflumethiazide can be decreased when used in combination with Lumiracoxib.Approved, Investigational
Hygromycin BLumiracoxib may decrease the excretion rate of Hygromycin B which could result in a higher serum level.Vet Approved
IbandronateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Ibandronate.Approved, Investigational
IbuprofenThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Lumiracoxib.Approved
IbuproxamThe risk or severity of adverse effects can be increased when Ibuproxam is combined with Lumiracoxib.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Icatibant is combined with Lumiracoxib.Approved, Investigational
IcosapentThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Icosapent.Approved, Nutraceutical
IdraparinuxLumiracoxib may increase the anticoagulant activities of Idraparinux.Investigational
IloprostThe therapeutic efficacy of Iloprost can be decreased when used in combination with Lumiracoxib.Approved, Investigational
ImidaprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Imidapril.Investigational
Imidazole salicylateThe risk or severity of adverse effects can be increased when Imidazole salicylate is combined with Lumiracoxib.Experimental
IndalpineIndalpine may increase the antiplatelet activities of Lumiracoxib.Investigational, Withdrawn
IndapamideThe therapeutic efficacy of Indapamide can be decreased when used in combination with Lumiracoxib.Approved
IndenololLumiracoxib may decrease the antihypertensive activities of Indenolol.Withdrawn
IndinavirThe metabolism of Lumiracoxib can be decreased when combined with Indinavir.Approved
IndobufenThe risk or severity of adverse effects can be increased when Indobufen is combined with Lumiracoxib.Investigational
IndomethacinThe risk or severity of adverse effects can be increased when Indomethacin is combined with Lumiracoxib.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Indoprofen is combined with Lumiracoxib.Withdrawn
IrbesartanThe metabolism of Lumiracoxib can be decreased when combined with Irbesartan.Approved, Investigational
IsepamicinLumiracoxib may decrease the excretion rate of Isepamicin which could result in a higher serum level.Experimental
IsoniazidThe metabolism of Lumiracoxib can be decreased when combined with Isoniazid.Approved, Investigational
IsoxicamThe risk or severity of adverse effects can be increased when Isoxicam is combined with Lumiracoxib.Withdrawn
IstaroximeThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Istaroxime.Investigational
KanamycinLumiracoxib may decrease the excretion rate of Kanamycin which could result in a higher serum level.Approved, Investigational, Vet Approved
KebuzoneThe risk or severity of adverse effects can be increased when Kebuzone is combined with Lumiracoxib.Experimental
KetoconazoleThe metabolism of Lumiracoxib can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenThe risk or severity of adverse effects can be increased when Ketoprofen is combined with Lumiracoxib.Approved, Vet Approved
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Lumiracoxib.Approved
LabetalolLumiracoxib may decrease the antihypertensive activities of Labetalol.Approved
LandiololLumiracoxib may decrease the antihypertensive activities of Landiolol.Investigational
LatanoprostThe therapeutic efficacy of Latanoprost can be decreased when used in combination with Lumiracoxib.Approved, Investigational
Latanoprostene BunodThe therapeutic efficacy of Latanoprostene Bunod can be decreased when used in combination with Lumiracoxib.Approved, Investigational
LeflunomideThe risk or severity of adverse effects can be increased when Leflunomide is combined with Lumiracoxib.Approved, Investigational
LepirudinLumiracoxib may increase the anticoagulant activities of Lepirudin.Approved
LetaxabanLumiracoxib may increase the anticoagulant activities of Letaxaban.Investigational
LevobetaxololLumiracoxib may decrease the antihypertensive activities of Levobetaxolol.Approved, Investigational
LevobunololLumiracoxib may decrease the antihypertensive activities of Levobunolol.Approved
LevofloxacinLumiracoxib may increase the neuroexcitatory activities of Levofloxacin.Approved, Investigational
LevomilnacipranLevomilnacipran may increase the antiplatelet activities of Lumiracoxib.Approved, Investigational
LidocaineThe metabolism of Lumiracoxib can be decreased when combined with Lidocaine.Approved, Vet Approved
LimaprostThe therapeutic efficacy of Limaprost can be decreased when used in combination with Lumiracoxib.Approved, Investigational
LisinoprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Lisinopril.Approved, Investigational
LisofyllineThe risk or severity of adverse effects can be increased when Lisofylline is combined with Lumiracoxib.Investigational
LithiumThe serum concentration of Lithium can be increased when it is combined with Lumiracoxib.Approved
LobeglitazoneThe metabolism of Lumiracoxib can be decreased when combined with Lobeglitazone.Approved, Investigational
LomefloxacinLumiracoxib may increase the neuroexcitatory activities of Lomefloxacin.Approved, Investigational
LonazolacThe risk or severity of adverse effects can be increased when Lonazolac is combined with Lumiracoxib.Experimental
LopinavirThe metabolism of Lumiracoxib can be increased when combined with Lopinavir.Approved
LornoxicamThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Lornoxicam.Approved, Investigational
LosartanThe metabolism of Lumiracoxib can be decreased when combined with Losartan.Approved
LoteprednolThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Loteprednol.Approved
LovastatinThe metabolism of Lumiracoxib can be decreased when combined with Lovastatin.Approved, Investigational
LoxoprofenThe risk or severity of adverse effects can be increased when Loxoprofen is combined with Lumiracoxib.Approved, Investigational
LubiprostoneThe therapeutic efficacy of Lubiprostone can be decreased when used in combination with Lumiracoxib.Approved, Investigational
LuliconazoleThe serum concentration of Lumiracoxib can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Lumiracoxib can be decreased when it is combined with Lumacaftor.Approved
LuprostiolThe therapeutic efficacy of Luprostiol can be decreased when used in combination with Lumiracoxib.Vet Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Magnesium salicylate.Approved
ManidipineThe metabolism of Lumiracoxib can be decreased when combined with Manidipine.Approved, Investigational
MasoprocolThe risk or severity of adverse effects can be increased when Masoprocol is combined with Lumiracoxib.Approved, Investigational
ME-609The risk or severity of adverse effects can be increased when Lumiracoxib is combined with ME-609.Investigational
Meclofenamic acidThe risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Lumiracoxib.Approved, Vet Approved
MedrysoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Medrysone.Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Mefenamic acid is combined with Lumiracoxib.Approved
MelagatranLumiracoxib may increase the anticoagulant activities of Melagatran.Experimental
MelengestrolThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Melengestrol.Vet Approved
MeloxicamThe risk or severity of adverse effects can be increased when Meloxicam is combined with Lumiracoxib.Approved, Vet Approved
MepindololLumiracoxib may decrease the antihypertensive activities of Mepindolol.Experimental
MesalazineThe risk or severity of adverse effects can be increased when Mesalazine is combined with Lumiracoxib.Approved
MestranolLumiracoxib may increase the thrombogenic activities of Mestranol.Approved
MetamizoleThe risk or severity of adverse effects can be increased when Metamizole is combined with Lumiracoxib.Approved, Investigational, Withdrawn
MethallenestrilLumiracoxib may increase the thrombogenic activities of Methallenestril.Experimental
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Lumiracoxib.Approved
MethyclothiazideThe therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Lumiracoxib.Approved
MethylprednisoloneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Methylprednisolone.Approved, Vet Approved
MetipranololLumiracoxib may decrease the antihypertensive activities of Metipranolol.Approved
MetolazoneThe therapeutic efficacy of Metolazone can be decreased when used in combination with Lumiracoxib.Approved
MetoprololLumiracoxib may decrease the antihypertensive activities of Metoprolol.Approved, Investigational
MexiletineThe metabolism of Lumiracoxib can be decreased when combined with Mexiletine.Approved, Investigational
MicronomicinLumiracoxib may decrease the excretion rate of Micronomicin which could result in a higher serum level.Experimental
MidostaurinThe metabolism of Lumiracoxib can be decreased when combined with Midostaurin.Approved, Investigational
MifamurtideThe therapeutic efficacy of Mifamurtide can be decreased when used in combination with Lumiracoxib.Approved, Experimental
MifepristoneThe serum concentration of Lumiracoxib can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranMilnacipran may increase the antiplatelet activities of Lumiracoxib.Approved, Investigational
MisoprostolThe therapeutic efficacy of Misoprostol can be decreased when used in combination with Lumiracoxib.Approved
MizoribineThe risk or severity of adverse effects can be increased when Mizoribine is combined with Lumiracoxib.Investigational
MoclobemideThe metabolism of Lumiracoxib can be decreased when combined with Moclobemide.Approved, Investigational
ModafinilThe metabolism of Lumiracoxib can be decreased when combined with Modafinil.Approved, Investigational
MoexiprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Moexipril.Approved
MofebutazoneThe risk or severity of adverse effects can be increased when Mofebutazone is combined with Lumiracoxib.Experimental
MometasoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Mometasone.Approved, Vet Approved
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Lumiracoxib.Approved
MoxestrolLumiracoxib may increase the thrombogenic activities of Moxestrol.Experimental
MoxifloxacinLumiracoxib may increase the neuroexcitatory activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Lumiracoxib.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Lumiracoxib.Approved
NabiloneThe metabolism of Lumiracoxib can be decreased when combined with Nabilone.Approved, Investigational
NabumetoneThe risk or severity of adverse effects can be increased when Nabumetone is combined with Lumiracoxib.Approved
NadololLumiracoxib may decrease the antihypertensive activities of Nadolol.Approved
NadroparinLumiracoxib may increase the anticoagulant activities of Nadroparin.Approved, Investigational
NafamostatThe risk or severity of adverse effects can be increased when Nafamostat is combined with Lumiracoxib.Approved, Investigational
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Lumiracoxib.Approved
Nalidixic AcidLumiracoxib may increase the neuroexcitatory activities of Nalidixic Acid.Approved, Investigational
NaproxenThe risk or severity of adverse effects can be increased when Naproxen is combined with Lumiracoxib.Approved, Vet Approved
NCX 1022The risk or severity of adverse effects can be increased when Lumiracoxib is combined with NCX 1022.Investigational
NeamineLumiracoxib may decrease the excretion rate of Neamine which could result in a higher serum level.Experimental
NebivololLumiracoxib may decrease the antihypertensive activities of Nebivolol.Approved, Investigational
NefazodoneNefazodone may increase the antiplatelet activities of Lumiracoxib.Approved, Withdrawn
NelfinavirThe metabolism of Lumiracoxib can be decreased when combined with Nelfinavir.Approved
NemonoxacinLumiracoxib may increase the neuroexcitatory activities of Nemonoxacin.Investigational
NeomycinLumiracoxib may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
NepafenacThe risk or severity of adverse effects can be increased when Nepafenac is combined with Lumiracoxib.Approved, Investigational
NetilmicinLumiracoxib may decrease the excretion rate of Netilmicin which could result in a higher serum level.Approved, Investigational
NevirapineThe metabolism of Lumiracoxib can be decreased when combined with Nevirapine.Approved
NicardipineThe metabolism of Lumiracoxib can be decreased when combined with Nicardipine.Approved, Investigational
NifenazoneThe risk or severity of adverse effects can be increased when Nifenazone is combined with Lumiracoxib.Experimental
Niflumic AcidThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Niflumic Acid.Approved
NimesulideThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Nimesulide.Approved, Investigational, Withdrawn
NitroaspirinThe risk or severity of adverse effects can be increased when Nitroaspirin is combined with Lumiracoxib.Investigational
NorfloxacinLumiracoxib may increase the neuroexcitatory activities of Norfloxacin.Approved
OfloxacinLumiracoxib may increase the neuroexcitatory activities of Ofloxacin.Approved
Oleoyl-estroneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Oleoyl-estrone.Investigational
OlmesartanThe risk or severity of adverse effects can be increased when Olmesartan is combined with Lumiracoxib.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Lumiracoxib.Approved
OlsalazineThe risk or severity of adverse effects can be increased when Olsalazine is combined with Lumiracoxib.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Lumiracoxib is combined with Omacetaxine mepesuccinate.Approved, Investigational
OmapatrilatThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Omapatrilat.Investigational
OmeprazoleThe metabolism of Lumiracoxib can be decreased when combined with Omeprazole.Approved, Investigational, Vet Approved
OrgoteinThe risk or severity of adverse effects can be increased when Orgotein is combined with Lumiracoxib.Vet Approved
OsimertinibThe serum concentration of Lumiracoxib can be decreased when it is combined with Osimertinib.Approved
OtamixabanLumiracoxib may increase the anticoagulant activities of Otamixaban.Investigational
OxaprozinThe risk or severity of adverse effects can be increased when Oxaprozin is combined with Lumiracoxib.Approved
Oxolinic acidLumiracoxib may increase the neuroexcitatory activities of Oxolinic acid.Experimental
OxprenololLumiracoxib may decrease the antihypertensive activities of Oxprenolol.Approved
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Oxyphenbutazone is combined with Lumiracoxib.Approved, Withdrawn
PalmidrolThe risk or severity of adverse effects can be increased when Palmidrol is combined with Lumiracoxib.Experimental, Nutraceutical
PamidronateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Pamidronate.Approved
PantoprazoleThe metabolism of Lumiracoxib can be decreased when combined with Pantoprazole.Approved
ParamethasoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Paramethasone.Approved
ParecoxibThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Parecoxib.Approved
ParomomycinLumiracoxib may decrease the excretion rate of Paromomycin which could result in a higher serum level.Approved, Investigational
ParoxetineParoxetine may increase the antiplatelet activities of Lumiracoxib.Approved, Investigational
ParthenolideThe risk or severity of adverse effects can be increased when Parthenolide is combined with Lumiracoxib.Approved, Investigational
PazufloxacinLumiracoxib may increase the neuroexcitatory activities of Pazufloxacin.Investigational
PefloxacinLumiracoxib may increase the neuroexcitatory activities of Pefloxacin.Approved
Peginterferon alfa-2bThe serum concentration of Lumiracoxib can be increased when it is combined with Peginterferon alfa-2b.Approved
PenbutololLumiracoxib may decrease the antihypertensive activities of Penbutolol.Approved, Investigational
Pentaerythritol TetranitrateLumiracoxib may increase the anticoagulant activities of Pentaerythritol Tetranitrate.Approved
Pentosan PolysulfateLumiracoxib may increase the anticoagulant activities of Pentosan Polysulfate.Approved
PerindoprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Perindopril.Approved
PhenindioneLumiracoxib may increase the anticoagulant activities of Phenindione.Approved, Investigational
PhenobarbitalThe metabolism of Lumiracoxib can be increased when combined with Phenobarbital.Approved, Investigational
PhenprocoumonLumiracoxib may increase the anticoagulant activities of Phenprocoumon.Approved, Investigational
PhenylbutazoneThe risk or severity of adverse effects can be increased when Phenylbutazone is combined with Lumiracoxib.Approved, Vet Approved
PhenytoinThe metabolism of Lumiracoxib can be increased when combined with Phenytoin.Approved, Vet Approved
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Lumiracoxib.Approved, Investigational
PindololLumiracoxib may decrease the antihypertensive activities of Pindolol.Approved, Investigational
Pipemidic acidLumiracoxib may increase the neuroexcitatory activities of Pipemidic acid.Experimental
PiretanideThe therapeutic efficacy of Piretanide can be decreased when used in combination with Lumiracoxib.Approved
PirfenidoneThe risk or severity of adverse effects can be increased when Pirfenidone is combined with Lumiracoxib.Approved, Investigational
Piromidic acidLumiracoxib may increase the neuroexcitatory activities of Piromidic acid.Experimental
PiroxicamThe risk or severity of adverse effects can be increased when Piroxicam is combined with Lumiracoxib.Approved, Investigational
PirprofenThe risk or severity of adverse effects can be increased when Pirprofen is combined with Lumiracoxib.Experimental
PitolisantThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Pitolisant.Approved, Investigational
Platelet Activating FactorLumiracoxib may decrease the antihypertensive activities of Platelet Activating Factor.Experimental
PlazomicinLumiracoxib may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
Polyestradiol phosphateLumiracoxib may increase the thrombogenic activities of Polyestradiol phosphate.Approved
PolythiazideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Lumiracoxib.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Pomalidomide.Approved
Potassium CitrateLumiracoxib may increase the anticoagulant activities of Potassium Citrate.Approved, Investigational, Vet Approved
PractololLumiracoxib may decrease the antihypertensive activities of Practolol.Approved
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Lumiracoxib.Approved, Investigational
PranoprofenThe risk or severity of adverse effects can be increased when Pranoprofen is combined with Lumiracoxib.Experimental, Investigational
PrasteroneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Prasterone.Approved, Investigational, Nutraceutical
Prasterone sulfateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Prasterone sulfate.Investigational
PrednicarbateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Prednicarbate.Approved, Investigational
PrednisoloneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Prednisolone.Approved, Vet Approved
PrednisoneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Prednisone.Approved, Vet Approved
PregnenoloneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Pregnenolone.Approved, Experimental, Investigational
PrimidoneThe metabolism of Lumiracoxib can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Lumiracoxib can be increased when it is combined with Probenecid.Approved, Investigational
ProglumetacinThe risk or severity of adverse effects can be increased when Proglumetacin is combined with Lumiracoxib.Experimental
PromestrieneLumiracoxib may increase the thrombogenic activities of Promestriene.Investigational
PropacetamolThe risk or severity of adverse effects can be increased when Propacetamol is combined with Lumiracoxib.Approved, Investigational
PropafenoneLumiracoxib may decrease the antihypertensive activities of Propafenone.Approved
PropranololLumiracoxib may decrease the antihypertensive activities of Propranolol.Approved, Investigational
PropyphenazoneThe risk or severity of adverse effects can be increased when Propyphenazone is combined with Lumiracoxib.Experimental
ProquazoneThe risk or severity of adverse effects can be increased when Proquazone is combined with Lumiracoxib.Experimental
Prostaglandin B2The therapeutic efficacy of Prostaglandin B2 can be decreased when used in combination with Lumiracoxib.Experimental
Prostaglandin G2The therapeutic efficacy of Prostaglandin G2 can be decreased when used in combination with Lumiracoxib.Experimental
ProstaleneThe therapeutic efficacy of Prostalene can be decreased when used in combination with Lumiracoxib.Vet Approved
Protein CLumiracoxib may increase the anticoagulant activities of Protein C.Approved
Protein S humanLumiracoxib may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeLumiracoxib may increase the anticoagulant activities of Protocatechualdehyde.Approved
PrulifloxacinLumiracoxib may increase the neuroexcitatory activities of Prulifloxacin.Investigational
PTC299The risk or severity of adverse effects can be increased when PTC299 is combined with Lumiracoxib.Investigational
PuromycinLumiracoxib may decrease the excretion rate of Puromycin which could result in a higher serum level.Experimental
PyrimethamineThe metabolism of Lumiracoxib can be decreased when combined with Pyrimethamine.Approved, Investigational, Vet Approved
QuinaprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Quinapril.Approved, Investigational
QuinestrolLumiracoxib may increase the thrombogenic activities of Quinestrol.Approved
QuinethazoneThe therapeutic efficacy of Quinethazone can be decreased when used in combination with Lumiracoxib.Approved
QuinineThe metabolism of Lumiracoxib can be decreased when combined with Quinine.Approved
RamiprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Ramipril.Approved
RescinnamineThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Rescinnamine.Approved
ResveratrolThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Resveratrol.Approved, Experimental, Investigational
ReviparinLumiracoxib may increase the anticoagulant activities of Reviparin.Approved, Investigational
RibostamycinLumiracoxib may decrease the excretion rate of Ribostamycin which could result in a higher serum level.Approved, Investigational
RifampicinThe metabolism of Lumiracoxib can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Lumiracoxib can be increased when combined with Rifapentine.Approved, Investigational
RimexoloneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Rimexolone.Approved
RisedronateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Risedronate.Approved, Investigational
RivaroxabanLumiracoxib may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibThe risk or severity of adverse effects can be increased when Rofecoxib is combined with Lumiracoxib.Approved, Investigational, Withdrawn
RopiniroleThe metabolism of Lumiracoxib can be decreased when combined with Ropinirole.Approved, Investigational
RosoxacinLumiracoxib may increase the neuroexcitatory activities of Rosoxacin.Approved, Investigational
RucaparibThe metabolism of Lumiracoxib can be decreased when combined with Rucaparib.Approved, Investigational
RufloxacinLumiracoxib may increase the neuroexcitatory activities of Rufloxacin.Experimental
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Lumiracoxib.Approved
SalicylamideThe risk or severity of adverse effects can be increased when Salicylamide is combined with Lumiracoxib.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Lumiracoxib.Approved, Investigational, Vet Approved
SalsalateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Salsalate.Approved
SaprisartanThe risk or severity of adverse effects can be increased when Saprisartan is combined with Lumiracoxib.Experimental
SaralasinThe risk or severity of adverse effects can be increased when Saralasin is combined with Lumiracoxib.Investigational
SarilumabSarilumab may increase the immunosuppressive activities of Lumiracoxib.Approved, Investigational
SecobarbitalThe metabolism of Lumiracoxib can be increased when combined with Secobarbital.Approved, Vet Approved
SecoisolariciresinolLumiracoxib may increase the thrombogenic activities of Secoisolariciresinol.Investigational
SeliciclibThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Seliciclib.Investigational
SemapimodThe risk or severity of adverse effects can be increased when Semapimod is combined with Lumiracoxib.Investigational
SeratrodastThe risk or severity of adverse effects can be increased when Seratrodast is combined with Lumiracoxib.Approved
SerrapeptaseThe risk or severity of adverse effects can be increased when Serrapeptase is combined with Lumiracoxib.Investigational
SertralineSertraline may increase the antiplatelet activities of Lumiracoxib.Approved
SildenafilThe metabolism of Lumiracoxib can be decreased when combined with Sildenafil.Approved, Investigational
SimeprevirThe metabolism of Lumiracoxib can be decreased when combined with Simeprevir.Approved
SisomicinLumiracoxib may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
SitafloxacinLumiracoxib may increase the neuroexcitatory activities of Sitafloxacin.Experimental, Investigational
Sodium CitrateLumiracoxib may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Sodium phosphateSodium phosphate may increase the nephrotoxic activities of Lumiracoxib.Approved
SorafenibThe metabolism of Lumiracoxib can be decreased when combined with Sorafenib.Approved, Investigational
SotalolLumiracoxib may decrease the antihypertensive activities of Sotalol.Approved
SparfloxacinLumiracoxib may increase the neuroexcitatory activities of Sparfloxacin.Approved, Investigational
SpiraprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Spirapril.Approved
SpironolactoneLumiracoxib may decrease the antihypertensive activities of Spironolactone.Approved
SRT501The risk or severity of adverse effects can be increased when SRT501 is combined with Lumiracoxib.Investigational
StiripentolThe metabolism of Lumiracoxib can be decreased when combined with Stiripentol.Approved
StreptomycinLumiracoxib may decrease the excretion rate of Streptomycin which could result in a higher serum level.Approved, Vet Approved
SulfadiazineThe metabolism of Lumiracoxib can be decreased when combined with Sulfadiazine.Approved, Investigational, Vet Approved
SulfamethoxazoleThe metabolism of Lumiracoxib can be decreased when combined with Sulfamethoxazole.Approved
SulfasalazineThe risk or severity of adverse effects can be increased when Sulfasalazine is combined with Lumiracoxib.Approved
SulfisoxazoleThe metabolism of Lumiracoxib can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulindacThe risk or severity of adverse effects can be increased when Sulindac is combined with Lumiracoxib.Approved, Investigational
SulodexideLumiracoxib may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SulprostoneThe therapeutic efficacy of Sulprostone can be decreased when used in combination with Lumiracoxib.Investigational
SuprofenThe risk or severity of adverse effects can be increased when Suprofen is combined with Lumiracoxib.Approved, Withdrawn
SuxibuzoneThe risk or severity of adverse effects can be increased when Suxibuzone is combined with Lumiracoxib.Experimental
Synthetic Conjugated Estrogens, ALumiracoxib may increase the thrombogenic activities of Synthetic Conjugated Estrogens, A.Approved
Synthetic Conjugated Estrogens, BLumiracoxib may increase the thrombogenic activities of Synthetic Conjugated Estrogens, B.Approved
TacrolimusLumiracoxib may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
TafluprostThe therapeutic efficacy of Tafluprost can be decreased when used in combination with Lumiracoxib.Approved
TalinololLumiracoxib may decrease the antihypertensive activities of Talinolol.Investigational
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Lumiracoxib.Approved
TarenflurbilThe risk or severity of adverse effects can be increased when Tarenflurbil is combined with Lumiracoxib.Investigational
TasosartanThe risk or severity of adverse effects can be increased when Tasosartan is combined with Lumiracoxib.Approved
Technetium Tc-99m etidronateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Technetium Tc-99m etidronate.Approved
Technetium Tc-99m medronateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Technetium Tc-99m medronate.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Telmisartan is combined with Lumiracoxib.Approved, Investigational
TemafloxacinLumiracoxib may increase the neuroexcitatory activities of Temafloxacin.Withdrawn
TemocaprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Temocapril.Experimental, Investigational
TenidapThe risk or severity of adverse effects can be increased when Tenidap is combined with Lumiracoxib.Experimental
Tenofovir disoproxilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Tenofovir disoproxil.Approved, Investigational
TenoxicamThe risk or severity of adverse effects can be increased when Tenoxicam is combined with Lumiracoxib.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Tepoxalin is combined with Lumiracoxib.Vet Approved
TerbutalineLumiracoxib may decrease the antihypertensive activities of Terbutaline.Approved
TeriflunomideThe serum concentration of Lumiracoxib can be decreased when it is combined with Teriflunomide.Approved
TertatololLumiracoxib may decrease the antihypertensive activities of Tertatolol.Experimental
TheophyllineThe metabolism of Lumiracoxib can be decreased when combined with Theophylline.Approved
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Tiaprofenic acid.Approved
TiboloneLumiracoxib may increase the thrombogenic activities of Tibolone.Approved, Investigational
TicagrelorThe metabolism of Lumiracoxib can be decreased when combined with Ticagrelor.Approved
TiclopidineThe metabolism of Lumiracoxib can be decreased when combined with Ticlopidine.Approved
Tiludronic acidThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Tiludronic acid.Approved, Investigational, Vet Approved
TimololLumiracoxib may decrease the antihypertensive activities of Timolol.Approved
TinoridineThe risk or severity of adverse effects can be increased when Tinoridine is combined with Lumiracoxib.Investigational
TioclomarolLumiracoxib may increase the anticoagulant activities of Tioclomarol.Experimental
TixocortolThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Tixocortol.Approved, Withdrawn
TobramycinLumiracoxib may decrease the excretion rate of Tobramycin which could result in a higher serum level.Approved, Investigational
TolbutamideThe metabolism of Lumiracoxib can be decreased when combined with Tolbutamide.Approved, Investigational
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Tolfenamic Acid is combined with Lumiracoxib.Approved, Investigational
TolmetinThe risk or severity of adverse effects can be increased when Tolmetin is combined with Lumiracoxib.Approved
TopiramateThe metabolism of Lumiracoxib can be decreased when combined with Topiramate.Approved
TopiroxostatThe metabolism of Lumiracoxib can be decreased when combined with Topiroxostat.Approved, Investigational
TorasemideThe therapeutic efficacy of Torasemide can be decreased when used in combination with Lumiracoxib.Approved
TrandolaprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Trandolapril.Approved
TranilastThe risk or severity of adverse effects can be increased when Tranilast is combined with Lumiracoxib.Approved, Investigational
TranylcypromineThe metabolism of Lumiracoxib can be decreased when combined with Tranylcypromine.Approved, Investigational
TravoprostThe therapeutic efficacy of Travoprost can be decreased when used in combination with Lumiracoxib.Approved
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Lumiracoxib.Approved, Investigational
TriamcinoloneThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Triamcinolone.Approved, Vet Approved
TriamtereneLumiracoxib may decrease the antihypertensive activities of Triamterene.Approved
TribenosideThe risk or severity of adverse effects can be increased when Tribenoside is combined with Lumiracoxib.Experimental
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Lumiracoxib.Approved, Vet Approved
TrimethoprimThe metabolism of Lumiracoxib can be decreased when combined with Trimethoprim.Approved, Vet Approved
TriptolideThe risk or severity of adverse effects can be increased when Triptolide is combined with Lumiracoxib.Investigational
Trolamine salicylateThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Trolamine salicylate.Approved
TrovafloxacinLumiracoxib may increase the neuroexcitatory activities of Trovafloxacin.Approved, Investigational, Withdrawn
TroxerutinLumiracoxib may increase the anticoagulant activities of Troxerutin.Investigational
UlobetasolThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Ulobetasol.Approved
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Lumiracoxib.Approved, Investigational
ValdecoxibThe risk or severity of adverse effects can be increased when Valdecoxib is combined with Lumiracoxib.Approved, Investigational, Withdrawn
Valproic AcidThe metabolism of Lumiracoxib can be decreased when combined with Valproic Acid.Approved, Investigational
ValsartanThe metabolism of Lumiracoxib can be decreased when combined with Valsartan.Approved, Investigational
VancomycinThe serum concentration of Vancomycin can be increased when it is combined with Lumiracoxib.Approved
VemurafenibThe serum concentration of Lumiracoxib can be increased when it is combined with Vemurafenib.Approved
VenlafaxineVenlafaxine may increase the antiplatelet activities of Lumiracoxib.Approved
VoriconazoleThe metabolism of Lumiracoxib can be decreased when combined with Voriconazole.Approved, Investigational
WarfarinLumiracoxib may increase the anticoagulant activities of Warfarin.Approved
XimelagatranLumiracoxib may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
ZafirlukastThe metabolism of Lumiracoxib can be decreased when combined with Zafirlukast.Approved, Investigational
ZaltoprofenThe risk or severity of adverse effects can be increased when Zaltoprofen is combined with Lumiracoxib.Approved, Investigational
ZeranolLumiracoxib may increase the thrombogenic activities of Zeranol.Vet Approved
ZileutonThe risk or severity of adverse effects can be increased when Zileuton is combined with Lumiracoxib.Approved, Investigational, Withdrawn
ZimelidineZimelidine may increase the antiplatelet activities of Lumiracoxib.Withdrawn
ZofenoprilThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Zofenopril.Experimental
Zoledronic acidThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Zoledronic acid.Approved
ZomepiracThe risk or severity of adverse effects can be increased when Zomepirac is combined with Lumiracoxib.Withdrawn
ZucapsaicinThe metabolism of Lumiracoxib can be decreased when combined with Zucapsaicin.Approved, Investigational
Food Interactions
  • Take with or without food. Food has no effect on the absorption of the product.

References

General References
Not Available
External Links
Human Metabolome Database
HMDB0015403
KEGG Drug
D03714
PubChem Compound
151166
PubChem Substance
46506378
ChemSpider
133236
BindingDB
50207446
ChEBI
73044
ChEMBL
CHEMBL404108
Therapeutic Targets Database
DAP000970
PharmGKB
PA164769031
HET
LUR
Wikipedia
Lumiracoxib
ATC Codes
M01AH06 — Lumiracoxib
PDB Entries
4iiz / 4ik6 / 4oty / 4rrw / 4rrx / 4rrz

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2TerminatedTreatmentArthralgia / Kidney Failure,Chronic1
3CompletedTreatmentKnee Osteoarthritis (Knee OA)2
3CompletedTreatmentOsteoarthritis (OA)4
3CompletedTreatmentOsteoarthritis (OA) / Rheumatoid Arthritis1
3CompletedTreatmentOsteoarthritis, Hip1
4CompletedTreatmentAcute Gouty Arthritis1
4CompletedTreatmentControlled Hypertension / Osteoarthritis (OA)1
4CompletedTreatmentHealthy Volunteers1
4CompletedTreatmentOsteoarthritis With Controlled Hypertension1
4CompletedTreatmentPain2
4CompletedTreatmentPainful musculoskeletal conditions1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
logP3.9Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00549 mg/mLALOGPS
logP4.56ALOGPS
logP4.31ChemAxon
logS-4.7ALOGPS
pKa (Strongest Acidic)4.11ChemAxon
pKa (Strongest Basic)-1.9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area49.33 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity75.91 m3·mol-1ChemAxon
Polarizability28.53 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9825
Blood Brain Barrier+0.9715
Caco-2 permeable+0.818
P-glycoprotein substrateNon-substrate0.7336
P-glycoprotein inhibitor INon-inhibitor0.7134
P-glycoprotein inhibitor IINon-inhibitor0.9389
Renal organic cation transporterNon-inhibitor0.916
CYP450 2C9 substrateNon-substrate0.7247
CYP450 2D6 substrateNon-substrate0.8639
CYP450 3A4 substrateNon-substrate0.5964
CYP450 1A2 substrateInhibitor0.5208
CYP450 2C9 inhibitorInhibitor0.6844
CYP450 2D6 inhibitorNon-inhibitor0.8163
CYP450 2C19 inhibitorNon-inhibitor0.8576
CYP450 3A4 inhibitorNon-inhibitor0.8063
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6222
Ames testNon AMES toxic0.8453
CarcinogenicityNon-carcinogens0.6326
BiodegradationNot ready biodegradable0.9954
Rat acute toxicity3.5160 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9512
hERG inhibition (predictor II)Non-inhibitor0.7169
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as aminotoluenes. These are organic aromatic compounds containing a benzene that carries a single methyl group and one amino group.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Toluenes
Direct Parent
Aminotoluenes
Alternative Parents
Aniline and substituted anilines / Fluorobenzenes / Chlorobenzenes / Aryl fluorides / Aryl chlorides / Amino acids / Secondary amines / Monocarboxylic acids and derivatives / Carboxylic acids / Organopnictogen compounds
show 5 more
Substituents
Aminotoluene / Aniline or substituted anilines / Chlorobenzene / Fluorobenzene / Halobenzene / Aryl chloride / Aryl fluoride / Aryl halide / Amino acid or derivatives / Amino acid
show 17 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
organofluorine compound, monocarboxylic acid, organochlorine compound, secondary amino compound, amino acid (CHEBI:73044)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
Gene Name
PTGS2
Uniprot ID
P35354
Uniprot Name
Prostaglandin G/H synthase 2
Molecular Weight
68995.625 Da
References
  1. Capone ML, Tacconelli S, Sciulli MG, Patrignani P: Clinical pharmacology of selective COX-2 inhibitors. Int J Immunopathol Pharmacol. 2003 May-Aug;16(2 Suppl):49-58. [PubMed:14552704]
  2. Tacconelli S, Capone ML, Patrignani P: Clinical pharmacology of novel selective COX-2 inhibitors. Curr Pharm Des. 2004;10(6):589-601. [PubMed:14965322]
  3. Atherton C, Jones J, McKaig B, Bebb J, Cunliffe R, Burdsall J, Brough J, Stevenson D, Bonner J, Rordorf C, Scott G, Branson J, Hawkey CJ: Pharmacology and gastrointestinal safety of lumiracoxib, a novel cyclooxygenase-2 selective inhibitor: An integrated study. Clin Gastroenterol Hepatol. 2004 Feb;2(2):113-20. [PubMed:15017615]
  4. Kalbag J, Yeh CM, Milosavljev S, Lasseter K, Oberstein S, Rordorf C: No influence of moderate hepatic impairment on the pharmacokinetics of lumiracoxib, an oral COX-2 selective inhibitor. Pharmacol Res. 2004 Aug;50(2):181-6. [PubMed:15177307]
  5. Esser R, Berry C, Du Z, Dawson J, Fox A, Fujimoto RA, Haston W, Kimble EF, Koehler J, Peppard J, Quadros E, Quintavalla J, Toscano K, Urban L, van Duzer J, Zhang X, Zhou S, Marshall PJ: Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. Br J Pharmacol. 2005 Feb;144(4):538-50. [PubMed:15655513]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gas...
Gene Name
PTGS1
Uniprot ID
P23219
Uniprot Name
Prostaglandin G/H synthase 1
Molecular Weight
68685.82 Da
References
  1. Capone ML, Tacconelli S, Sciulli MG, Patrignani P: Clinical pharmacology of selective COX-2 inhibitors. Int J Immunopathol Pharmacol. 2003 May-Aug;16(2 Suppl):49-58. [PubMed:14552704]
  2. Esser R, Berry C, Du Z, Dawson J, Fox A, Fujimoto RA, Haston W, Kimble EF, Koehler J, Peppard J, Quadros E, Quintavalla J, Toscano K, Urban L, van Duzer J, Zhang X, Zhou S, Marshall PJ: Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. Br J Pharmacol. 2005 Feb;144(4):538-50. [PubMed:15655513]
  3. Jermany J, Branson J, Schmouder R, Guillaume M, Rordorf C: Lumiracoxib does not affect the ex vivo antiplatelet aggregation activity of low-dose aspirin in healthy subjects. J Clin Pharmacol. 2005 Oct;45(10):1172-8. [PubMed:16172182]
  4. Warner TD, Vojnovic I, Bishop-Bailey D, Mitchell JA: Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2. FASEB J. 2006 Mar;20(3):542-4. Epub 2006 Jan 10. [PubMed:16403783]
  5. Blobaum AL, Marnett LJ: Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib. J Biol Chem. 2007 Jun 1;282(22):16379-90. Epub 2007 Apr 12. [PubMed:17434872]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Retinoic acid binding
Specific Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks trans...
Gene Name
UGT1A9
Uniprot ID
O60656
Uniprot Name
UDP-glucuronosyltransferase 1-9
Molecular Weight
59940.495 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on May 17, 2007 10:57 / Updated on June 02, 2018 06:47