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Identification
NameDronabinol
Accession NumberDB00470  (APRD00571)
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionA psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. Dronabinol is a synthetic form of delta-9-THC. [PubChem]
Structure
Thumb
Synonyms
(-)-delta9-trans-Tetrahydrocannabinol
1-trans-delta-9-Tetrahydrocannabinol
3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,D)pyran-1-ol
6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
delta-9-tetrahydrocannabinol
delta-9-THC
delta(1)-Tetrahydrocannabinol
delta(9)-THC
delta9-Tetrahydrocannabinol
Dronabinol
Dronabinolum
Tetrahydrocannabinol
Δ9-tetrahydrocannabinol
External Identifiers
  • Abbott 40566
  • Dea No. 7369
  • Dea No. 7370
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DronabinolCapsule5 mg/1OralActavis Pharma, Inc.2005-06-07Not applicableUs
DronabinolCapsule10 mg/1OralActavis Pharma, Inc.1994-08-11Not applicableUs
DronabinolCapsule2.5 mg/1OralActavis Pharma, Inc.1994-08-11Not applicableUs
MarinolCapsule2.5 mg/1OralAbb Vie Inc.2010-07-13Not applicableUs
MarinolCapsule5 mg/1OralAbb Vie Inc.2010-07-13Not applicableUs
MarinolCapsule2.5 mgOralAbbott Laboratories, Limited1994-12-312012-02-24Canada
MarinolCapsule10 mg/1OralAbb Vie Inc.2010-07-13Not applicableUs
MarinolCapsule5 mgOralAbbott Laboratories, Limited1994-12-312012-02-24Canada
Marinol Cap 10mgCapsule10 mgOralSolvay Pharma Inc1994-12-312008-07-24Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DronabinolCapsule5 mg/1OralPar Pharmaceutical Inc.2008-06-27Not applicableUs
DronabinolCapsule, liquid filled2.5 mg/1OralMylan Pharmaceuticals Inc.2011-11-01Not applicableUs
DronabinolCapsule5 mg/1OralAmerican Health Packaging2010-09-07Not applicableUs
DronabinolCapsule5 mg/1OralAkorn, Inc.2014-06-20Not applicableUs
DronabinolCapsule10 mg/1OralPar Pharmaceutical Inc.2008-06-27Not applicableUs
DronabinolCapsule, liquid filled5 mg/1OralMylan Pharmaceuticals Inc.2011-11-01Not applicableUs
DronabinolCapsule10 mg/1OralAkorn, Inc.2014-06-20Not applicableUs
DronabinolCapsule5 mg/1OralPhysicians Total Care, Inc.2008-08-19Not applicableUs
DronabinolCapsule, liquid filled10 mg/1OralMylan Pharmaceuticals Inc.2011-11-01Not applicableUs
DronabinolCapsule2.5 mg/1OralPar Pharmaceutical Inc.2008-06-27Not applicableUs
DronabinolCapsule2.5 mg/1OralAmerican Health Packaging2010-09-07Not applicableUs
DronabinolCapsule2.5 mg/1OralAkorn, Inc.2014-06-20Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
SativexGw Pharma Limited
SaltsNot Available
Categories
UNII7J8897W37S
CAS number1972-08-3
WeightAverage: 314.4617
Monoisotopic: 314.224580204
Chemical FormulaC21H30O2
InChI KeyCYQFCXCEBYINGO-IAGOWNOFSA-N
InChI
InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1
IUPAC Name
(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol
SMILES
[H][C@@]12C=C(C)CC[C@@]1([H])C(C)(C)OC1=C2C(O)=CC(CCCCC)=C1
Pharmacology
IndicationFor the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments
Structured Indications
PharmacodynamicsMarinol may has complex effects on the central nervous system (CNS), including cannabinoid receptors. Dronabinol may inhibit endorphins in the emetic center, suppress prostaglandin synthesis, and/or inhibit medullary activity through an unspecified cortical action.
Mechanism of actionThe mechanism of action of marinol is not completely understood. It is thought that cannabinoid receptors in neural tissues may mediate the effects of dronabinol and other cannabinoids. Animal studies with other cannabinoids suggest that marinol's antiemetic effects may be due to inhibition of the vomiting control mechanism in the medulla oblongata.
TargetKindPharmacological actionActionsOrganismUniProt ID
Cannabinoid receptor 1Proteinyes
agonist
HumanP21554 details
Cannabinoid receptor 2Proteinunknown
agonist
HumanP34972 details
Related Articles
Absorption90 - 95%
Volume of distribution
  • 10 L/kg
Protein binding97%
Metabolism

Hepatic

SubstrateEnzymesProduct
Dronabinol
11-Hydroxy-delta-9-THCDetails
Dronabinol
7-beta-Hydroxy-delta-9-THCDetails
Dronabinol
7-alpha-Hydroxy-delta-9-THCDetails
Dronabinol
8-Hydroxy-delta-9-THCDetails
Dronabinol
8-beta-Hydroxy-delta-9-THCDetails
Dronabinol
9-alpha,10-alpha-epoxyhexahydrocannabinolDetails
8-Hydroxy-delta-9-THC
Not Available
8,11-Dihydroxy-delta-9-THCDetails
11-Hydroxy-delta-9-THC
Not Available
8,11-Dihydroxy-delta-9-THCDetails
11-Hydroxy-delta-9-THC
Not Available
11-Nor-9-carboxy-delta-9-THCDetails
Route of eliminationDronabinol and its biotransformation products are excreted in both feces and urine.
Half lifeAlpha phase: approximately 4 hours; Beta phase: 25-36 hours
Clearance
  • 0.2 L/kg-hr
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneDronabinol may increase the central nervous system depressant (CNS depressant) activities of 1,1,1,2 Tetrafluoroethane.Investigational
7-NitroindazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of 7-Nitroindazole.Experimental
AbirateroneThe serum concentration of Dronabinol can be increased when it is combined with Abiraterone.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Dronabinol.Approved
AcepromazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.Approved, Vet Approved
AceprometazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Dronabinol.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Dronabinol.Approved, Vet Approved
AclidiniumAclidinium may increase the tachycardic activities of Dronabinol.Approved
adipiplonDronabinol may increase the central nervous system depressant (CNS depressant) activities of adipiplon.Investigational
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Dronabinol.Approved
AgomelatineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.Approved, Investigational
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Dronabinol.Experimental
AlfaxaloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alfaxalone.Vet Approved
AlfentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.Approved, Illicit
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Dronabinol.Approved, Investigational
AlphacetylmethadolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alphacetylmethadol.Experimental, Illicit
AlprazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Dronabinol.Approved, Investigational
AmiodaroneThe serum concentration of Dronabinol can be increased when it is combined with Amiodarone.Approved, Investigational
AmisulprideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amisulpride.Approved, Investigational
AmitriptylineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.Approved
AmobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.Approved, Illicit
AmoxapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.Approved
AmperozideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amperozide.Experimental
AmphetamineDronabinol may increase the tachycardic activities of Amphetamine.Approved, Illicit
Anisotropine MethylbromideAnisotropine Methylbromide may increase the tachycardic activities of Dronabinol.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Dronabinol.Approved
AprepitantThe serum concentration of Dronabinol can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.Approved, Investigational
ArmodafinilThe metabolism of Dronabinol can be decreased when combined with Armodafinil.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Dronabinol.Approved, Investigational
ArticaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Articaine.Approved
AsenapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Asenapine.Approved
AtazanavirThe serum concentration of Dronabinol can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Dronabinol.Approved
AtomoxetineThe serum concentration of Dronabinol can be increased when it is combined with Atomoxetine.Approved
Atracurium besylateAtracurium besylate may increase the tachycardic activities of Dronabinol.Approved
AtropineAtropine may increase the tachycardic activities of Dronabinol.Approved, Vet Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Dronabinol.Approved, Investigational
AzaperoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Azaperone.Vet Approved
AzelastineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenDronabinol may increase the central nervous system depressant (CNS depressant) activities of Baclofen.Approved
BarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Barbital.Illicit
BenactyzineBenactyzine may increase the tachycardic activities of Dronabinol.Withdrawn
BenperidolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Benperidol.Investigational
BenzatropineBenzatropine may increase the tachycardic activities of Dronabinol.Approved
BenzocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.Approved
BenzphetamineDronabinol may increase the tachycardic activities of Benzphetamine.Approved, Illicit
Benzyl alcoholDronabinol may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Dronabinol.Approved, Vet Approved
BexaroteneThe serum concentration of Dronabinol can be decreased when it is combined with Bexarotene.Approved, Investigational
BiperidenBiperiden may increase the tachycardic activities of Dronabinol.Approved
BoceprevirThe serum concentration of Dronabinol can be increased when it is combined with Boceprevir.Approved
BortezomibThe serum concentration of Dronabinol can be increased when it is combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Dronabinol can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Dronabinol.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Dronabinol.Approved
BrexpiprazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.Approved
BrimonidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brimonidine.Approved
BromazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Dronabinol.Approved, Investigational
BrompheniramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.Approved
BrotizolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved, Withdrawn
BucindololDronabinol may increase the tachycardic activities of Bucindolol.Investigational
BupivacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved, Investigational
BuprenorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Buspirone.Approved, Investigational
ButabarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.Approved, Illicit
ButacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butacaine.Vet Approved
ButalbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butalbital.Approved, Illicit
ButambenDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butamben.Approved
ButethalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butethal.Approved, Illicit
ButorphanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.Approved, Illicit, Vet Approved
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Dronabinol.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Dronabinol.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Dronabinol.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Dronabinol.Approved
CapecitabineThe serum concentration of Dronabinol can be increased when it is combined with Capecitabine.Approved, Investigational
CarbamazepineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carbamazepine.Approved, Investigational
CarbinoxamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carbinoxamine.Approved
CarfentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Illicit, Vet Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Dronabinol.Approved
CarisoprodolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.Approved
CeliprololDronabinol may increase the tachycardic activities of Celiprolol.Approved, Investigational
CeritinibThe serum concentration of Dronabinol can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Dronabinol.Withdrawn
CetirizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.Approved
Chloral hydrateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Illicit, Vet Approved
ChloramphenicolThe metabolism of Dronabinol can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved, Illicit
ChlormezanoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.Approved, Withdrawn
ChloroprocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chloroprocaine.Approved
ChlorphenamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved
ChlorphenoxamineChlorphenoxamine may increase the tachycardic activities of Dronabinol.Withdrawn
ChlorphentermineDronabinol may increase the tachycardic activities of Chlorphentermine.Illicit, Withdrawn
ChlorpromazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.Approved, Vet Approved
ChlorprothixeneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved
CholecalciferolThe serum concentration of Dronabinol can be increased when it is combined with Cholecalciferol.Approved, Nutraceutical
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Dronabinol.Approved
CinchocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cinchocaine.Approved, Vet Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Dronabinol.Approved, Investigational
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Dronabinol.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Dronabinol.Approved
ClarithromycinThe serum concentration of Dronabinol can be increased when it is combined with Clarithromycin.Approved
ClemastineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved
ClenbuterolDronabinol may increase the tachycardic activities of Clenbuterol.Approved, Vet Approved
ClidiniumDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clidinium.Approved
ClobazamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Illicit
clomethiazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Dronabinol.Approved, Investigational
ClomipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.Approved, Vet Approved
ClonazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.Approved, Illicit
ClonidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clonidine.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Dronabinol.Approved, Nutraceutical
ClorazepateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clorazepate.Approved, Illicit
ClotrimazoleThe serum concentration of Dronabinol can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clozapine.Approved
CobicistatThe serum concentration of Dronabinol can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Dronabinol.Approved
CocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cocaine.Approved, Illicit
CodeineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Codeine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Dronabinol.Approved
ConivaptanThe serum concentration of Dronabinol can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Dronabinol.Approved
CrizotinibThe serum concentration of Dronabinol can be increased when it is combined with Crizotinib.Approved
CyclizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.Approved
CyclobenzaprineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.Approved
CyclopentolateCyclopentolate may increase the tachycardic activities of Dronabinol.Approved
CyclosporineThe serum concentration of Dronabinol can be increased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Dronabinol.Approved
DabrafenibThe serum concentration of Dronabinol can be decreased when it is combined with Dabrafenib.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Dronabinol.Approved
DantroleneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Dronabinol.Approved
DapiprazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dapiprazole.Approved
DarifenacinDarifenacin may increase the tachycardic activities of Dronabinol.Approved, Investigational
DarunavirThe serum concentration of Dronabinol can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Dronabinol can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Dronabinol.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Dronabinol.Approved
DeferasiroxThe serum concentration of Dronabinol can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe serum concentration of Dronabinol can be increased when it is combined with Delavirdine.Approved
deramciclaneDronabinol may increase the central nervous system depressant (CNS depressant) activities of deramciclane.Investigational
DesfluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved
DesipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Desipramine.Approved
DesloratadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.Approved, Investigational
DetomidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Detomidine.Vet Approved
DexamethasoneThe serum concentration of Dronabinol can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.Approved
DexetimideDexetimide may increase the tachycardic activities of Dronabinol.Withdrawn
DexmedetomidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.Approved, Vet Approved
DextromoramideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dextromoramide.Experimental, Illicit
DextropropoxypheneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved
DiazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Diazepam.Approved, Illicit, Vet Approved
DicyclomineDicyclomine may increase the tachycardic activities of Dronabinol.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Dronabinol.Approved
DifenoxinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.Approved, Illicit
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Dronabinol.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Dronabinol.Approved
DihydrocodeineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dihydrocodeine.Approved, Illicit
DihydroergotamineThe serum concentration of Dronabinol can be increased when it is combined with Dihydroergotamine.Approved
DihydroetorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dihydroetorphine.Experimental, Illicit
DihydromorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.Experimental, Illicit
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Dronabinol.Illicit
DiltiazemThe serum concentration of Dronabinol can be increased when it is combined with Diltiazem.Approved
DimenhydrinateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.Approved
DiphenhydramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved
DiphenoxylateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Diphenoxylate.Approved, Illicit
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Dronabinol.Approved
DobutamineDronabinol may increase the tachycardic activities of Dobutamine.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Dronabinol.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Dronabinol.Approved, Investigational, Vet Approved
DopamineDronabinol may increase the tachycardic activities of Dopamine.Approved
DoramectinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Doramectin.Vet Approved
DoxepinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Dronabinol.Approved, Investigational
DoxycyclineThe serum concentration of Dronabinol can be increased when it is combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved, Vet Approved
DPDPEDronabinol may increase the central nervous system depressant (CNS depressant) activities of DPDPE.Investigational
DronedaroneThe serum concentration of Dronabinol can be increased when it is combined with Dronedarone.Approved
DroperidolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Droperidol.Approved, Vet Approved
DrotebanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Drotebanol.Experimental, Illicit
DyclonineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.Approved
EcgonineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERDronabinol may increase the central nervous system depressant (CNS depressant) activities of ECGONINE METHYL ESTER.Experimental
EcopipamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ecopipam.Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Dronabinol.Approved
EfavirenzDronabinol may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Dronabinol.Approved, Investigational
EnfluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Enflurane.Approved, Vet Approved
EntacaponeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of Dronabinol can be decreased when it is combined with Enzalutamide.Approved
EphedrineDronabinol may increase the tachycardic activities of Ephedrine.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Dronabinol.Approved, Investigational
EpinephrineDronabinol may increase the tachycardic activities of Epinephrine.Approved, Vet Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Dronabinol.Approved, Investigational
ErythromycinThe serum concentration of Dronabinol can be increased when it is combined with Erythromycin.Approved, Vet Approved
Eslicarbazepine acetateThe serum concentration of Dronabinol can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe metabolism of Dronabinol can be decreased when combined with Esomeprazole.Approved, Investigational
EstazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Estazolam.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Dronabinol.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Dronabinol.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Dronabinol.Approved
EszopicloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.Approved
EthanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethchlorvynol.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Dronabinol.Approved
EthopropazineEthopropazine may increase the tachycardic activities of Dronabinol.Approved
EthosuximideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.Approved
EthotoinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethotoin.Approved
Ethyl carbamateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethyl carbamate.Withdrawn
Ethyl loflazepateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethyl loflazepate.Approved, Illicit
EthylmorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.Approved, Illicit
EtidocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.Approved
EtifoxineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Withdrawn
EtilefrineDronabinol may increase the tachycardic activities of Etilefrine.Withdrawn
EtizolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etizolam.Approved
EtomidateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etomidate.Approved
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Dronabinol.Approved
EtorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Illicit, Vet Approved
EtravirineThe serum concentration of Dronabinol can be increased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Dronabinol.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Dronabinol.Approved
EzogabineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ezogabine.Approved
FelbamateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Felbamate.Approved
FencamfamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fencamfamine.Approved, Illicit, Withdrawn
FenoterolDronabinol may increase the tachycardic activities of Fenoterol.Approved
FentanylDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.Approved, Illicit, Investigational, Vet Approved
FesoterodineFesoterodine may increase the tachycardic activities of Dronabinol.Approved
FexofenadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Dronabinol.Approved
FlibanserinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.Approved
FloxuridineThe serum concentration of Dronabinol can be increased when it is combined with Floxuridine.Approved
FluconazoleThe serum concentration of Dronabinol can be increased when it is combined with Fluconazole.Approved
FludiazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fludiazepam.Approved, Illicit
FlunarizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flunarizine.Approved
FlunitrazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flunitrazepam.Approved, Illicit
FluorouracilThe serum concentration of Dronabinol can be increased when it is combined with Fluorouracil.Approved
FluoxetineThe metabolism of Dronabinol can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.Approved, Withdrawn
FluphenazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.Approved
FlurazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.Approved, Illicit
FluspirileneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Dronabinol.Approved
Fluticasone PropionateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.Approved
FluvastatinThe serum concentration of Dronabinol can be increased when it is combined with Fluvastatin.Approved
FluvoxamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fluvoxamine.Approved, Investigational
FosamprenavirThe serum concentration of Dronabinol can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Dronabinol can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.Approved
FospropofolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.Approved, Illicit
Fusidic AcidThe serum concentration of Dronabinol can be increased when it is combined with Fusidic Acid.Approved
GabapentinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.Approved, Investigational
gabapentin enacarbilDronabinol may increase the central nervous system depressant (CNS depressant) activities of gabapentin enacarbil.Approved
Gallamine TriethiodideGallamine Triethiodide may increase the tachycardic activities of Dronabinol.Approved
Gamma Hydroxybutyric AcidDronabinol may increase the central nervous system depressant (CNS depressant) activities of Gamma Hydroxybutyric Acid.Approved, Illicit
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Dronabinol.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Dronabinol.Approved
GemfibrozilThe serum concentration of Dronabinol can be increased when it is combined with Gemfibrozil.Approved
GepironeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Investigational
GlutethimideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Illicit
GlycopyrroniumGlycopyrronium may increase the tachycardic activities of Dronabinol.Approved, Investigational, Vet Approved
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Dronabinol.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Dronabinol.Withdrawn
GuanfacineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.Approved, Investigational
HalazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Halazepam.Approved, Illicit, Withdrawn
HaloperidolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.Approved
HalothaneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Halothane.Approved, Vet Approved
HeroinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved, Illicit
HexamethoniumHexamethonium may increase the tachycardic activities of Dronabinol.Experimental
HexobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.Approved
HomatropineHomatropine may increase the tachycardic activities of Dronabinol.Approved
HydrocodoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Dronabinol.Approved, Vet Approved
HydromorphoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.Approved, Illicit
Hydroxyamphetamine hydrobromideDronabinol may increase the tachycardic activities of Hydroxyamphetamine hydrobromide.Approved
HydroxyzineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.Approved
HyoscyamineHyoscyamine may increase the tachycardic activities of Dronabinol.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Dronabinol.Approved
IdelalisibThe serum concentration of Dronabinol can be increased when it is combined with Idelalisib.Approved
IloperidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.Approved
ImatinibThe serum concentration of Dronabinol can be increased when it is combined with Imatinib.Approved
ImipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Imipramine.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Dronabinol.Approved
IndinavirThe serum concentration of Dronabinol can be increased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Dronabinol.Approved, Investigational
Ipratropium bromideIpratropium bromide may increase the tachycardic activities of Dronabinol.Approved
IrbesartanThe serum concentration of Dronabinol can be increased when it is combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Dronabinol.Approved, Investigational
IsavuconazoniumThe serum concentration of Dronabinol can be increased when it is combined with Isavuconazonium.Approved, Investigational
IsofluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Isoflurane.Approved, Vet Approved
IsoniazidThe metabolism of Dronabinol can be decreased when combined with Isoniazid.Approved
IsoprenalineDronabinol may increase the tachycardic activities of Isoprenaline.Approved
IsoxsuprineDronabinol may increase the tachycardic activities of Isoxsuprine.Approved, Withdrawn
IsradipineThe serum concentration of Dronabinol can be increased when it is combined with Isradipine.Approved
ItraconazoleThe serum concentration of Dronabinol can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Dronabinol can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Dronabinol.Approved, Vet Approved
KetamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ketamine.Approved, Vet Approved
KetazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.Approved
KetobemidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.Approved
KetoconazoleThe serum concentration of Dronabinol can be increased when it is combined with Ketoconazole.Approved, Investigational
LabetalolDronabinol may increase the tachycardic activities of Labetalol.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Dronabinol.Approved, Investigational
LamotrigineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Dronabinol.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Dronabinol.Approved
LeflunomideThe serum concentration of Dronabinol can be increased when it is combined with Leflunomide.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Dronabinol.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Dronabinol.Approved
LevetiracetamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.Approved, Investigational
LevobupivacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.Approved
LevocabastineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.Approved
LevocetirizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.Approved
LevodopaDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levodopa.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Dronabinol.Approved, Investigational
Levomethadyl AcetateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levomethadyl Acetate.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Dronabinol.Approved
LevorphanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.Approved
LidocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Dronabinol.Approved
LithiumDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lithium.Approved
LofentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.Illicit
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Dronabinol.Approved
LopinavirThe serum concentration of Dronabinol can be increased when it is combined with Lopinavir.Approved
LoratadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved
LorazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved
LosartanThe serum concentration of Dronabinol can be increased when it is combined with Losartan.Approved
LovastatinThe serum concentration of Dronabinol can be increased when it is combined with Lovastatin.Approved, Investigational
LoxapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Loxapine.Approved
Lu AA21004Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Lu AA21004.Investigational
LuliconazoleThe serum concentration of Dronabinol can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Dronabinol can be decreased when it is combined with Lumacaftor.Approved
LurasidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.Approved
Magnesium SulfateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Magnesium Sulfate.Approved, Vet Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Dronabinol.Approved, Investigational
MaprotilineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.Approved
MecamylamineMecamylamine may increase the tachycardic activities of Dronabinol.Approved
MeclizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved
MedetomidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Medetomidine.Vet Approved
MelatoninDronabinol may increase the central nervous system depressant (CNS depressant) activities of Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Melperone.Approved
MephentermineDronabinol may increase the tachycardic activities of Mephentermine.Approved
MepivacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine.Approved, Vet Approved
MeprobamateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.Approved, Illicit
MesoridazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Mesoridazine.Approved
MetaraminolDronabinol may increase the tachycardic activities of Metaraminol.Approved, Investigational
MetaxaloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.Approved
MethadoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methadone.Approved
Methadyl AcetateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved, Illicit
MethamphetamineDronabinol may increase the tachycardic activities of Methamphetamine.Approved, Illicit
MethanthelineMethantheline may increase the tachycardic activities of Dronabinol.Approved
MethapyrileneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methapyrilene.Withdrawn
MethaqualoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Illicit, Withdrawn
MethocarbamolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.Approved, Vet Approved
MethohexitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methohexital.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Dronabinol.Approved
MethotrimeprazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxamineDronabinol may increase the tachycardic activities of Methoxamine.Approved
MethoxyfluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methoxyflurane.Approved, Vet Approved
MethsuximideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.Approved
MethylphenobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methylphenobarbital.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Dronabinol.Approved, Vet Approved
MetixeneMetixene may increase the tachycardic activities of Dronabinol.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Dronabinol.Approved, Investigational
MidazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Midazolam.Approved, Illicit
MidodrineDronabinol may increase the tachycardic activities of Midodrine.Approved
MifepristoneThe serum concentration of Dronabinol can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Dronabinol.Approved
MirtazapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Dronabinol can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Dronabinol.Approved, Investigational
MoclobemideThe metabolism of Dronabinol can be decreased when combined with Moclobemide.Approved
ModafinilThe serum concentration of Dronabinol can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Molindone.Approved
MorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Morphine.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Dronabinol.Approved, Investigational
N-butylscopolammonium bromideN-butylscopolammonium bromide may increase the tachycardic activities of Dronabinol.Vet Approved
NabiloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Dronabinol.Approved
NafcillinThe serum concentration of Dronabinol can be decreased when it is combined with Nafcillin.Approved
NalbuphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Dronabinol.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Dronabinol.Approved, Vet Approved
NefazodoneThe serum concentration of Dronabinol can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Dronabinol can be increased when it is combined with Nelfinavir.Approved
NetupitantThe serum concentration of Dronabinol can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Dronabinol can be increased when it is combined with Nevirapine.Approved
NicardipineThe serum concentration of Dronabinol can be increased when it is combined with Nicardipine.Approved
NicotineThe metabolism of Dronabinol can be decreased when combined with Nicotine.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Dronabinol.Approved
NilotinibThe serum concentration of Dronabinol can be increased when it is combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Dronabinol.Approved
NitrazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved
Nitrous oxideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Vet Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Dronabinol.Approved
NorepinephrineDronabinol may increase the tachycardic activities of Norepinephrine.Approved
NormethadoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Normethadone.Approved, Illicit
NortriptylineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.Approved
NVA237NVA237 may increase the tachycardic activities of Dronabinol.Investigational
NylidrinDronabinol may increase the tachycardic activities of Nylidrin.Approved
OlanzapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.Approved, Investigational
OlaparibThe serum concentration of Dronabinol can be increased when it is combined with Olaparib.Approved
OlopatadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Dronabinol.Approved
OmeprazoleThe serum concentration of Dronabinol can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ondansetron.Approved
OpiumDronabinol may increase the central nervous system depressant (CNS depressant) activities of Opium.Approved, Illicit
OrciprenalineDronabinol may increase the tachycardic activities of Orciprenaline.Approved
OrphenadrineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantDronabinol may increase the central nervous system depressant (CNS depressant) activities of Osanetant.Investigational
OsimertinibThe serum concentration of Dronabinol can be increased when it is combined with Osimertinib.Approved
OxazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.Approved
OxetacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxetacaine.Investigational
OxprenololDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxprenolol.Approved
OxybuprocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.Approved
OxybutyninOxybutynin may increase the tachycardic activities of Dronabinol.Approved, Investigational
OxycodoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.Approved, Illicit, Investigational
OxymetazolineDronabinol may increase the tachycardic activities of Oxymetazoline.Approved
OxymorphoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.Approved, Investigational, Vet Approved
OxyphenoniumOxyphenonium may increase the tachycardic activities of Dronabinol.Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Dronabinol.Approved, Vet Approved
PalbociclibThe serum concentration of Dronabinol can be increased when it is combined with Palbociclib.Approved
PaliperidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.Approved
PancuroniumPancuronium may increase the tachycardic activities of Dronabinol.Approved
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Dronabinol.Approved, Investigational
PantoprazoleThe metabolism of Dronabinol can be decreased when combined with Pantoprazole.Approved
ParaldehydeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Dronabinol.Approved
PentazocineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.Approved, Vet Approved
PentobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pentobarbital.Approved, Vet Approved
PentoliniumPentolinium may increase the tachycardic activities of Dronabinol.Approved
PerampanelDronabinol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.Approved
PerazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Perazine.Investigational
PerospironeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Perospirone.Approved
PerphenazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.Approved
PethidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pethidine.Approved
PhenmetrazineDronabinol may increase the tachycardic activities of Phenmetrazine.Approved, Illicit
PhenobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.Approved
PhenoxyethanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.Approved
PhentermineDronabinol may increase the tachycardic activities of Phentermine.Approved, Illicit
PhenylephrineDronabinol may increase the tachycardic activities of Phenylephrine.Approved
PhenylpropanolamineDronabinol may increase the tachycardic activities of Phenylpropanolamine.Approved, Vet Approved, Withdrawn
PhenytoinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Phenytoin.Approved, Vet Approved
PimozideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pimozide.Approved
PipamperoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.Approved
PipecuroniumPipecuronium may increase the tachycardic activities of Dronabinol.Approved
PipotiazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.Approved
PirenzepinePirenzepine may increase the tachycardic activities of Dronabinol.Approved
PiritramideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Piritramide.Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Dronabinol.Approved
PizotifenDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.Approved
PomalidomideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Dronabinol.Approved
PosaconazoleThe serum concentration of Dronabinol can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PramocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Dronabinol.Approved
PrazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Prazepam.Approved, Illicit
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Dronabinol.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Dronabinol.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Dronabinol.Approved, Vet Approved
PregabalinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Illicit, Investigational
PregnanoloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pregnanolone.Investigational
PrilocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.Approved
PrimidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved, Vet Approved
ProcaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Procaine.Approved, Investigational, Vet Approved
ProcaterolDronabinol may increase the tachycardic activities of Procaterol.Approved
ProchlorperazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.Approved, Vet Approved
ProcyclidineProcyclidine may increase the tachycardic activities of Dronabinol.Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Dronabinol.Approved, Vet Approved
PromazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Promazine.Approved, Vet Approved
PromethazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Promethazine.Approved
PropanthelinePropantheline may increase the tachycardic activities of Dronabinol.Approved
ProparacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved, Vet Approved
PropiverinePropiverine may increase the tachycardic activities of Dronabinol.Investigational
PropofolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Propofol.Approved, Investigational, Vet Approved
PropoxycaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Dronabinol.Approved, Investigational
ProtriptylineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Dronabinol.Approved
PSD502Dronabinol may increase the central nervous system depressant (CNS depressant) activities of PSD502.Investigational
PseudoephedrineDronabinol may increase the tachycardic activities of Pseudoephedrine.Approved
PyrimethamineThe serum concentration of Dronabinol can be increased when it is combined with Pyrimethamine.Approved, Vet Approved
QuazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Quazepam.Approved, Illicit
QuetiapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.Approved
QuinidineQuinidine may increase the tachycardic activities of Dronabinol.Approved
QuinineThe serum concentration of Dronabinol can be increased when it is combined with Quinine.Approved
RacepinephrineDronabinol may increase the tachycardic activities of Racepinephrine.Approved
RacloprideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Raclopride.Investigational
RamelteonDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Dronabinol.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Dronabinol.Approved, Investigational
RemifentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Remifentanil.Approved
RemoxiprideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.Approved, Withdrawn
ReserpineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Reserpine.Approved
RifabutinThe serum concentration of Dronabinol can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Dronabinol can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Dronabinol can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Dronabinol.Approved, Investigational
RisperidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Risperidone.Approved, Investigational
RitanserinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ritanserin.Investigational
RitodrineDronabinol may increase the tachycardic activities of Ritodrine.Approved
RitonavirThe serum concentration of Dronabinol can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Dronabinol.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Dronabinol.Approved, Investigational
RomifidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Romifidine.Vet Approved
RopivacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.Approved
S-EthylisothioureaDronabinol may increase the central nervous system depressant (CNS depressant) activities of S-Ethylisothiourea.Experimental
Sage 547Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Sage 547.Investigational
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Dronabinol.Approved, Vet Approved
SaquinavirThe serum concentration of Dronabinol can be increased when it is combined with Saquinavir.Approved, Investigational
ScopolamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Scopolamine.Approved
Scopolamine butylbromideScopolamine butylbromide may increase the tachycardic activities of Dronabinol.Approved
SecobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.Approved, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Dronabinol.Approved
SertindoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sertindole.Approved, Withdrawn
SertralineThe metabolism of Dronabinol can be decreased when combined with Sertraline.Approved
SevofluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sevoflurane.Approved, Vet Approved
SildenafilThe serum concentration of Dronabinol can be increased when it is combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Dronabinol.Approved
SiltuximabThe serum concentration of Dronabinol can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Dronabinol can be increased when it is combined with Simeprevir.Approved
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Dronabinol.Approved, Investigational
Sodium oxybateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Dronabinol.Approved
SolifenacinSolifenacin may increase the tachycardic activities of Dronabinol.Approved
SorafenibThe serum concentration of Dronabinol can be increased when it is combined with Sorafenib.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Dronabinol.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Dronabinol.Experimental
St. John's WortThe serum concentration of Dronabinol can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Dronabinol can be increased when it is combined with Stiripentol.Approved
SufentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sufentanil.Approved, Investigational
SulfadiazineThe serum concentration of Dronabinol can be increased when it is combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Dronabinol can be increased when it is combined with Sulfamethoxazole.Approved
SulfisoxazoleThe serum concentration of Dronabinol can be increased when it is combined with Sulfisoxazole.Approved, Vet Approved
SulpirideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.Approved
SuvorexantDronabinol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
SynephrineDronabinol may increase the tachycardic activities of Synephrine.Experimental
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Dronabinol.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Dronabinol.Approved
TandospironeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tandospirone.Investigational
TapentadolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.Approved
TasimelteonDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Dronabinol.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dronabinol.Approved
TelaprevirThe serum concentration of Dronabinol can be increased when it is combined with Telaprevir.Approved
TelithromycinThe serum concentration of Dronabinol can be increased when it is combined with Telithromycin.Approved
TemazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Temazepam.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Dronabinol.Approved
TerbutalineDronabinol may increase the tachycardic activities of Terbutaline.Approved
TetrabenazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tetrabenazine.Approved
TetracaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tetracaine.Approved, Vet Approved
TetrodotoxinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin.Investigational
TetryzolineDronabinol may increase the tachycardic activities of Tetryzoline.Approved
ThalidomideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thiamylal.Approved, Vet Approved
ThiopentalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thiopental.Approved, Vet Approved
ThioridazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.Approved
ThiothixeneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.Approved
TiagabineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.Approved
TiaprideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tiapride.Investigational
TicagrelorThe serum concentration of Dronabinol can be increased when it is combined with Ticagrelor.Approved
TiclopidineThe serum concentration of Dronabinol can be increased when it is combined with Ticlopidine.Approved
TiletamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tiletamine.Vet Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Dronabinol.Approved
TiotropiumTiotropium may increase the tachycardic activities of Dronabinol.Approved
TizanidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.Approved
TocilizumabThe serum concentration of Dronabinol can be decreased when it is combined with Tocilizumab.Approved
TolbutamideThe serum concentration of Dronabinol can be increased when it is combined with Tolbutamide.Approved
TolcaponeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.Approved, Withdrawn
TolterodineTolterodine may increase the tachycardic activities of Dronabinol.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Dronabinol.Approved
TopiramateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Topiramate.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Dronabinol.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Dronabinol.Approved, Investigational
TramadolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tramadol.Approved, Investigational
Trans-2-PhenylcyclopropylamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tranylcypromine.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Dronabinol.Approved
TrazodoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Trazodone.Approved, Investigational
TriazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Triazolam.Approved
TrifluoperazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.Approved
TriflupromazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Triflupromazine.Approved, Vet Approved
TrihexyphenidylTrihexyphenidyl may increase the tachycardic activities of Dronabinol.Approved
TrimethaphanTrimethaphan may increase the tachycardic activities of Dronabinol.Approved
TrimethoprimThe serum concentration of Dronabinol can be increased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved
TriprolidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.Approved
TropicamideTropicamide may increase the tachycardic activities of Dronabinol.Approved
TrospiumTrospium may increase the tachycardic activities of Dronabinol.Approved
TubocurarineTubocurarine may increase the tachycardic activities of Dronabinol.Approved
TyramineDronabinol may increase the tachycardic activities of Tyramine.Investigational, Nutraceutical
Uc1010Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Uc1010.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Dronabinol.Approved
UmeclidiniumUmeclidinium may increase the tachycardic activities of Dronabinol.Approved
Valproic AcidDronabinol may increase the central nervous system depressant (CNS depressant) activities of Valproic Acid.Approved, Investigational
ValsartanThe serum concentration of Dronabinol can be increased when it is combined with Valsartan.Approved, Investigational
VecuroniumVecuronium may increase the tachycardic activities of Dronabinol.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Dronabinol.Approved
VenlafaxineThe serum concentration of Dronabinol can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Dronabinol can be increased when it is combined with Verapamil.Approved
VigabatrinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Dronabinol.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Dronabinol.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Dronabinol.Approved
VoriconazoleThe serum concentration of Dronabinol can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.Approved
XylazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Xylazine.Vet Approved
ZafirlukastThe serum concentration of Dronabinol can be increased when it is combined with Zafirlukast.Approved, Investigational
ZaleplonDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.Approved, Illicit, Investigational
ZiconotideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ziconotide.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Dronabinol.Approved
ZiprasidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.Approved
ZolazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.Vet Approved
ZolpidemDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.Approved, Investigational
ZopicloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zopiclone.Approved
ZotepineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zotepine.Approved
ZuclopenthixolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.
References
Synthesis Reference

Fabio E.S. SOUZA, Jason E. FIELD, Ming PAN, “INTERMEDIATE COMPOUNDS IN THE SYNTHESIS OF DRONABINOL.” U.S. Patent US20080312465, issued December 18, 2008.

US20080312465
General ReferencesNot Available
External Links
ATC CodesA04AD10
AHFS Codes
  • 56:22.92
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (51.4 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9949
Blood Brain Barrier+0.9685
Caco-2 permeable+0.7607
P-glycoprotein substrateSubstrate0.8458
P-glycoprotein inhibitor INon-inhibitor0.5548
P-glycoprotein inhibitor IIInhibitor0.7191
Renal organic cation transporterNon-inhibitor0.8169
CYP450 2C9 substrateNon-substrate0.7522
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7199
CYP450 1A2 substrateInhibitor0.6567
CYP450 2C9 inhibitorInhibitor0.5352
CYP450 2D6 inhibitorNon-inhibitor0.7307
CYP450 2C19 inhibitorInhibitor0.7683
CYP450 3A4 inhibitorNon-inhibitor0.6771
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8349
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8947
BiodegradationNot ready biodegradable0.9725
Rat acute toxicity2.5940 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7714
hERG inhibition (predictor II)Non-inhibitor0.8136
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Svc pharma lp
  • Abbott products inc
  • Roxane Laboratories,Inc.
Packagers
Dosage forms
FormRouteStrength
Capsule, liquid filledOral10 mg/1
Capsule, liquid filledOral2.5 mg/1
Capsule, liquid filledOral5 mg/1
CapsuleOral10 mg/1
CapsuleOral2.5 mg/1
CapsuleOral2.5 mg
CapsuleOral5 mg
CapsuleOral5 mg/1
CapsuleOral10 mg
SprayBuccal
Prices
Unit descriptionCostUnit
Marinol 10 mg capsule29.86USD capsule
Dronabinol 10 mg capsule19.26USD capsule
Marinol 5 mg capsule16.0USD capsule
Dronabinol 5 mg capsule11.8USD capsule
Marinol 2.5 mg capsule8.02USD capsule
Dronabinol 2.5 mg capsule5.11USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6703418 No1994-02-262011-02-26Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point200 °C at 2.00E-02 mm HgNot Available
water solubility2800 mg/L (at 23 °C)NIH NTP Reports web-site
logP5.648Not Available
pKa10.6PHYSICIAN'S DESK REFERENCE (1998)
Predicted Properties
PropertyValueSource
Water Solubility0.00263 mg/mLALOGPS
logP7.29ALOGPS
logP5.94ChemAxon
logS-5.1ALOGPS
pKa (Strongest Acidic)9.34ChemAxon
pKa (Strongest Basic)-4.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area29.46 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity96.73 m3·mol-1ChemAxon
Polarizability38.96 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-01pp-4792000000-06532e533cb7794b7c37View in MoNA
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 2,2-dimethyl-1-benzopyrans. These are organic compounds containing a 1-benzopyran moiety that carries two methyl groups at the 2-position.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzopyrans
Sub Class1-benzopyrans
Direct Parent2,2-dimethyl-1-benzopyrans
Alternative Parents
Substituents
  • 2,2-dimethyl-1-benzopyran
  • Alkyl aryl ether
  • Benzenoid
  • Oxacycle
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Drug binding
Specific Function:
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
Gene Name:
CNR1
Uniprot ID:
P21554
Molecular Weight:
52857.365 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Pryce G, Giovannoni G, Baker D: Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice. Neurosci Lett. 2003 May 1;341(2):164-6. [PubMed:12686391 ]
  4. Tsai SJ, Wang YC, Hong CJ: Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia. Psychiatr Genet. 2000 Sep;10(3):149-51. [PubMed:11204352 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Cannabinoid receptor activity
Specific Function:
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Gene Name:
CNR2
Uniprot ID:
P34972
Molecular Weight:
39680.275 Da
References
  1. Davis M, Maida V, Daeninck P, Pergolizzi J: The emerging role of cannabinoid neuromodulators in symptom management. Support Care Cancer. 2007 Jan;15(1):63-71. Epub 2006 Dec 1. [PubMed:17139494 ]
  2. Pertwee RG: Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol. 2009 Feb;156(3):397-411. doi: 10.1111/j.1476-5381.2008.00048.x. [PubMed:19226257 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Tournier N, Chevillard L, Megarbane B, Pirnay S, Scherrmann JM, Decleves X: Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010 Aug;13(7):905-15. doi: 10.1017/S1461145709990848. Epub 2009 Nov 4. [PubMed:19887017 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Tournier N, Chevillard L, Megarbane B, Pirnay S, Scherrmann JM, Decleves X: Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010 Aug;13(7):905-15. doi: 10.1017/S1461145709990848. Epub 2009 Nov 4. [PubMed:19887017 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23