Postmenopausal Osteoporosis (PMO)

Also known as: Osteoporosis, Postmenopausal / Postmenopausal Osteoporosis / Osteoporosis, Post-Menopausal / Post-Menopausal Osteoporosis / Osteoporosis Postmenopausal / Post Menopausal Osteoporosis / Postmenopausal Osteoporoses / Type I osteoporosis

DrugDrug NameDrug Description
DB06401BazedoxifeneA selective estrogen receptor modulator (SERM) used to treat moderate to severe vasomotor symptoms in menopause and osteoporosis alone or in combination with conjugated estrogens.
DB00783EstradiolAn estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoarthritis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.
DB04574Estrone sulfateAn estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders.
DB00977EthinylestradiolAn estradiol used as a contraceptive.
DB00367LevonorgestrelA progestin found in oral and IUD contraceptives and at higher doses in emergency contraceptives.
DB00603Medroxyprogesterone acetateA progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.
DB00717NorethisteroneA synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.
DB00957NorgestimateA progesterone used as a contraceptive and to treat acne vulgaris.
DB00481RaloxifeneA selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women.
DrugDrug NameTargetType
DB06401BazedoxifeneEstrogen receptor alphatarget
DB06401BazedoxifeneUDP-glucuronosyltransferase 1-4enzyme
DB06401BazedoxifeneEstrogen receptor betatarget
DB06401BazedoxifeneUDP-glucuronosyltransferase 1-8enzyme
DB06401BazedoxifeneUDP-glucuronosyltransferase 1-10enzyme
DB00783EstradiolEstrogen receptor alphatarget
DB00783EstradiolNuclear receptor subfamily 1 group I member 2target
DB00783EstradiolSex hormone-binding globulincarrier
DB00783EstradiolEstrogen receptor betatarget
DB00783EstradiolCytochrome P450 1A2enzyme
DB00783EstradiolUDP-glucuronosyltransferase 1-1enzyme
DB00783EstradiolSerum albumincarrier
DB00783EstradiolFatty acid-binding protein, intestinalcarrier
DB00783EstradiolCytochrome P450 3A4enzyme
DB00783EstradiolCytochrome P450 3A5enzyme
DB00783EstradiolCytochrome P450 3A7enzyme
DB00783EstradiolSolute carrier family 22 member 2transporter
DB00783EstradiolSolute carrier family 22 member 1transporter
DB00783EstradiolSolute carrier family 22 member 3transporter
DB00783EstradiolSolute carrier organic anion transporter family member 2B1transporter
DB00783EstradiolSolute carrier organic anion transporter family member 1A2transporter
DB00783EstradiolMultidrug resistance-associated protein 7transporter
DB00783EstradiolSolute carrier family 22 member 11transporter
DB00783EstradiolATP-binding cassette sub-family G member 2transporter
DB00783EstradiolSolute carrier organic anion transporter family member 1B1transporter
DB00783EstradiolP-glycoprotein 1transporter
DB00783EstradiolCytochrome P450 1A1enzyme
DB00783EstradiolCytochrome P450 1B1enzyme
DB00783EstradiolCytochrome P450 2C19enzyme
DB00783EstradiolCytochrome P450 2C8enzyme
DB00783EstradiolCytochrome P450 2C9enzyme
DB00783EstradiolSolute carrier family 22 member 8transporter
DB00783EstradiolSolute carrier organic anion transporter family member 1B3transporter
DB00783EstradiolSolute carrier organic anion transporter family member 1C1transporter
DB00783EstradiolSolute carrier organic anion transporter family member 4A1transporter
DB00783EstradiolNeuronal acetylcholine receptor subunit alpha-4target
DB00783EstradiolNuclear receptor coactivator 2target
DB00783EstradiolG-protein coupled estrogen receptor 1target
DB00783EstradiolATP synthase subunit atarget
DB00783EstradiolBeclin-1target
DB00783EstradiolEstradiol 17-beta-dehydrogenase 2target
DB00783EstradiolEstrogen-related receptor gammatarget
DB04574Estrone sulfateCytochrome P450 1A2enzyme
DB04574Estrone sulfateCytochrome P450 3A4enzyme
DB04574Estrone sulfateEstrogen receptor alphatarget
DB04574Estrone sulfateEstrogen receptor betatarget
DB04574Estrone sulfateSex hormone-binding globulincarrier
DB04574Estrone sulfateSerum albumincarrier
DB04574Estrone sulfateCytochrome P450 2C9enzyme
DB04574Estrone sulfateMultidrug and toxin extrusion protein 1transporter
DB04574Estrone sulfateMultidrug and toxin extrusion protein 2transporter
DB00977EthinylestradiolEstrogen receptor alphatarget
DB00977EthinylestradiolNuclear receptor subfamily 1 group I member 2target
DB00977EthinylestradiolCytochrome P450 3A4enzyme
DB00977EthinylestradiolCytochrome P450 2C8enzyme
DB00977EthinylestradiolBile salt export pumptransporter
DB00977EthinylestradiolSodium/bile acid cotransportertransporter
DB00977EthinylestradiolCanalicular multispecific organic anion transporter 1transporter
DB00977EthinylestradiolP-glycoprotein 1transporter
DB00977EthinylestradiolSex hormone-binding globulintarget
DB00977EthinylestradiolUDP-glucuronosyltransferase 1-1enzyme
DB00977EthinylestradiolCytochrome P450 2C19enzyme
DB00367LevonorgestrelProgesterone receptortarget
DB00367LevonorgestrelEstrogen receptor alphatarget
DB00367Levonorgestrel3-oxo-5-alpha-steroid 4-dehydrogenase 1target
DB00367LevonorgestrelCytochrome P450 3A4enzyme
DB00367LevonorgestrelAndrogen receptortarget
DB00367LevonorgestrelSex hormone-binding globulintarget
DB00367LevonorgestrelGlucocorticoid receptortarget
DB00367LevonorgestrelCytochrome P450 3A5enzyme
DB00603Medroxyprogesterone acetateProgesterone receptortarget
DB00603Medroxyprogesterone acetateEstrogen receptor alphatarget
DB00603Medroxyprogesterone acetateCytochrome P450 3A4enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C8enzyme
DB00603Medroxyprogesterone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C9enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 3A1enzyme
DB00603Medroxyprogesterone acetateSerum albumincarrier
DB00603Medroxyprogesterone acetateP-glycoprotein 1target
DB00603Medroxyprogesterone acetateGABA-A receptor (anion channel)target
DB00717NorethisteroneProgesterone receptortarget
DB00717NorethisteroneP-glycoprotein 1transporter
DB00717NorethisteroneCytochrome P450 2C19enzyme
DB00717NorethisteroneSerum albumincarrier
DB00717NorethisteroneSex hormone-binding globulincarrier
DB00717NorethisteroneAldo-keto reductase family 1 member C4enzyme
DB00717Norethisterone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB00717Norethisterone3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
DB00717Norethisterone3-oxo-5-beta-steroid 4-dehydrogenaseenzyme
DB00717NorethisteroneCytochrome P450 3A4enzyme
DB00717NorethisteroneCytochrome P450 1A2enzyme
DB00717NorethisteroneCytochrome P450 2A6enzyme
DB00717NorethisteroneGlucocorticoid receptortarget
DB00717NorethisteroneAndrogen receptortarget
DB00957NorgestimateProgesterone receptortarget
DB00957NorgestimateEstrogen receptor alphatarget
DB00957NorgestimateCanalicular multispecific organic anion transporter 1transporter
DB00957NorgestimateCytochrome P450 3A4enzyme
DB00957NorgestimateAndrogen receptortarget
DB00481RaloxifeneEstrogen receptor alphatarget
DB00481RaloxifeneEstrogen receptor betatarget
DB00481RaloxifeneAldehyde oxidaseenzyme
DB00481RaloxifeneCytochrome P450 2C8enzyme
DB00481RaloxifeneCytochrome P450 2B6enzyme
DB00481RaloxifeneCytochrome P450 19A1enzyme
DB00481RaloxifeneCytochrome P450 3A4enzyme
DB00481RaloxifeneSerpin B9target
DB00481RaloxifeneTrefoil factor 1target
DB00481RaloxifeneUDP-glucuronosyltransferase 1-1enzyme
DB00481RaloxifeneSerum albumincarrier
DB00481RaloxifeneAlpha-1-acid glycoprotein 1carrier
DB00481RaloxifeneSolute carrier organic anion transporter family member 1B1transporter
DB00481RaloxifeneSolute carrier organic anion transporter family member 1B3transporter
DB00481RaloxifeneP-glycoprotein 1transporter
DB00481RaloxifeneATP-binding cassette sub-family G member 2transporter
DB00481RaloxifeneCanalicular multispecific organic anion transporter 1transporter
DB00481RaloxifeneCanalicular multispecific organic anion transporter 2transporter
DB00481RaloxifeneMultidrug resistance-associated protein 4transporter
DB00481RaloxifeneUDP-glucuronosyltransferase 1-10enzyme
DB00481RaloxifeneUDP-glucuronosyltransferase 1-8enzyme
DrugDrug NamePhaseStatusCount
DB12560Blosozumab1Completed1
DB12560Blosozumab1Terminated1
DB00286Conjugated estrogens1Completed1
DB06643Denosumab1Active Not Recruiting1
DB06643Denosumab1Completed1
DB00603Medroxyprogesterone acetate1Completed1
DB00683Midazolam1Completed1
DB06548Minodronic acid1Completed1
DB05829Parathyroid hormone1Completed1
DB11866Romosozumab1Completed1
DB00017Salmon Calcitonin1Completed2
DB06285Teriparatide1Completed3
DB05829Parathyroid hormone1 / 2Active Not Recruiting1
DB06285Teriparatide1 / 2Active Not Recruiting1
DB05084Abaloparatide2Completed1
DB00630Alendronic acid2Completed4
DB06401Bazedoxifene2Completed1
DB13975Black cohosh2Completed1
DB01373Calcium2Recruiting1
DB06724Calcium carbonate2Completed1
DB00169Cholecalciferol2Completed1
DB00169Cholecalciferol2Recruiting1
DB01609Deferasirox2Recruiting1
DB06643Denosumab2Completed3
DB00710Ibandronate2Completed1
DB06670Odanacatib2Completed1
DB05829Parathyroid hormone2Completed2
DB14290Rehmannia glutinosa root2Unknown Status1
DB00884Risedronic acid2Completed2
DB11866Romosozumab2Completed2
DB05581Teriparatide2Completed1
DB06285Teriparatide2Completed2
DB00399Zoledronic acid2Completed1
DB14936Menaquinone 62 / 3Recruiting1
DB12148Menatetrenone2 / 3Recruiting1
DB01022Phylloquinone2 / 3Recruiting1
DB05084Abaloparatide3Completed1
DB05084Abaloparatide3Recruiting2
DB00630Alendronic acid3Completed7
DB00630Alendronic acid3Withdrawn1
DB01436Alfacalcidol3Completed1
DB06249Arzoxifene3Completed2
DB01373Calcium3Completed1
DB06724Calcium carbonate3Completed1
DB00720Clodronic acid3Completed1
DB06643Denosumab3Completed9
DB00710Ibandronate3Completed6
DB00281Lidocaine3Completed1
DB06670Odanacatib3Terminated1
DB06670Odanacatib3Withdrawn1
DB00481Raloxifene3Completed4
DB00884Risedronic acid3Completed8
DB11866Romosozumab3Completed4
DB00017Salmon Calcitonin3Completed3
DB06285Teriparatide3Completed9
DB11094Vitamin D3Completed1
DB00399Zoledronic acid3Completed2
DB00630Alendronic acid4Completed5
DB00630Alendronic acid4Recruiting1
DB01436Alfacalcidol4Completed1
DB06401Bazedoxifene4Completed1
DB00136Calcitriol4Completed1
DB01373Calcium4Completed4
DB00169Cholecalciferol4Completed2
DB06643Denosumab4Active Not Recruiting1
DB06643Denosumab4Completed3
DB06643Denosumab4Recruiting4
DB00710Ibandronate4Completed16
DB00710Ibandronate4No Longer Available1
DB09125Potassium citrate4Unknown Status1
DB00481Raloxifene4Completed6
DB00481Raloxifene4Recruiting1
DB00481Raloxifene4Terminated1
DB00884Risedronic acid4Completed8
DB00884Risedronic acid4Terminated1
DB09267Strontium ranelate4Completed2
DB06285Teriparatide4Active Not Recruiting1
DB06285Teriparatide4Completed9
DB06285Teriparatide4Recruiting2
DB11094Vitamin D4Completed3
DB00399Zoledronic acid4Active Not Recruiting2
DB00399Zoledronic acid4Completed3
DB00399Zoledronic acid4Not Yet Recruiting1
DB00630Alendronic acidNot AvailableActive Not Recruiting1
DB00630Alendronic acidNot AvailableCompleted1
DB00630Alendronic acidNot AvailableNot Yet Recruiting1
DB06401BazedoxifeneNot AvailableCompleted1
DB06643DenosumabNot AvailableCompleted3
DB06643DenosumabNot AvailableRecruiting1
DB01395DrospirenoneNot AvailableCompleted1
DB00783EstradiolNot AvailableCompleted1
DB00710IbandronateNot AvailableCompleted1
DB00481RaloxifeneNot AvailableCompleted1
DB06285TeriparatideNot AvailableActive Not Recruiting1
DB06285TeriparatideNot AvailableCompleted2
DB06285TeriparatideNot AvailableRecruiting1
DB00399Zoledronic acidNot AvailableCompleted2