Gastric Ulcer (GU)

Also known as: Gastric Ulcer / Stomach Ulcer / Gastric Ulcers / NSAID-induced ulcer / NSAID Associated Gastric Ulcers / Prophylaxis of NSAID-induced ulcer / Prophylaxis of NSAID gastric ulceration / Gastric ulcer caused by NSAID / Ulcers, Stomach / Ulcer gastric / Ulcus ventriculi / Ulcer stomach / GU / Gastric ulcer prophylaxis / Prophylaxis against gastrointestinal ulcer

DrugDrug NameDrug Description
DB01050IbuprofenIbuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics.[A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin.[A39075] Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.[A39076] On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. The S-enantiomer is believed to be the more pharmacologically active enantiomer.[A39194]
DB00929MisoprostolA synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties.
DB00585NizatidineA histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.
DB00338OmeprazoleOriginally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs [A174232]. Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
DB00213PantoprazoleProton pump inhibitors, also known as _PPI_s are the most efficacious drugs for the initial treatment and for maintenance therapy of gastroesophageal reflux disease (GERD). Pantoprazole is a first-generation PPI that was initially approved by the FDA in 2000. It is also used to manage other disorders in which the decrease of gastric acid secretion is needed. This drug has been used over 100 countries worldwide. Pantoprazole is administered in several forms: a delayed-release oral capsule, oral suspension, as well as intravenous injection [F3193], [F3202], [FDA label].
DB01129RabeprazoleRabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
DB00364SucralfateA basic aluminum complex of sulfated sucrose. [PubChem]
DrugDrug NameTargetType
DB01050IbuprofenProstaglandin G/H synthase 1target
DB01050IbuprofenProstaglandin G/H synthase 2target
DB01050IbuprofenCytochrome P450 2C9enzyme
DB01050IbuprofenSerum albumincarrier
DB01050IbuprofenMultidrug resistance-associated protein 4transporter
DB01050IbuprofenMultidrug resistance-associated protein 1transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 1A2transporter
DB01050IbuprofenSolute carrier family 22 member 6transporter
DB01050IbuprofenSolute carrier family 22 member 8transporter
DB01050IbuprofenSolute carrier family 22 member 11transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 2B1transporter
DB01050IbuprofenMultidrug resistance protein 1transporter
DB01050IbuprofenUDP-glucuronosyltransferase 1-3enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1-9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B4enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenCytochrome P450 2C8enzyme
DB01050IbuprofenCytochrome P450 2C19enzyme
DB01050IbuprofenApoptosis regulator Bcl-2target
DB01050IbuprofenThrombomodulintarget
DB01050IbuprofenFatty acid-binding protein, intestinaltarget
DB01050IbuprofenPeroxisome proliferator-activated receptor gammatarget
DB01050IbuprofenCystic fibrosis transmembrane conductance regulatortarget
DB01050IbuprofenPeroxisome proliferator-activated receptor alphatarget
DB01050IbuprofenPlatelet glycoprotein Ib alpha chaintarget
DB01050IbuprofenProtein S100-A7target
DB01050IbuprofenAlpha-methylacyl-CoA racemaseenzyme
DB00929MisoprostolProstaglandin E2 receptor EP2 subtypetarget
DB00929MisoprostolProstaglandin E2 receptor EP3 subtypetarget
DB00929MisoprostolProstaglandin E2 receptor EP4 subtypetarget
DB00585NizatidineHistamine H2 receptortarget
DB00585NizatidineMultidrug resistance protein 1transporter
DB00585NizatidineCholinesteraseenzyme
DB00338OmeprazolePotassium-transporting ATPase alpha chain 1target
DB00338OmeprazoleCytochrome P450 2C19enzyme
DB00338OmeprazoleCytochrome P450 3A4enzyme
DB00338OmeprazoleCytochrome P450 2C9enzyme
DB00338OmeprazoleCytochrome P450 1A2enzyme
DB00338OmeprazoleCanalicular multispecific organic anion transporter 2transporter
DB00338OmeprazoleMultidrug resistance protein 1transporter
DB00338OmeprazoleATP-binding cassette sub-family G member 2transporter
DB00338OmeprazoleCytochrome P450 1A1enzyme
DB00338OmeprazoleCytochrome P450 1B1enzyme
DB00338OmeprazoleCytochrome P450 2C18enzyme
DB00338OmeprazoleCytochrome P450 2C8enzyme
DB00338OmeprazoleCytochrome P450 2D6enzyme
DB00338OmeprazoleAryl hydrocarbon receptortarget
DB00213PantoprazolePotassium-transporting ATPase alpha chain 1target
DB00213PantoprazoleCytochrome P450 2C19enzyme
DB00213PantoprazoleCytochrome P450 3A4enzyme
DB00213PantoprazoleMultidrug resistance protein 1transporter
DB00213PantoprazoleATP-binding cassette sub-family G member 2transporter
DB00213PantoprazoleSolute carrier organic anion transporter family member 1B1transporter
DB00213PantoprazoleSolute carrier organic anion transporter family member 1B3transporter
DB01129RabeprazolePotassium-transporting ATPase alpha chain 1target
DB01129RabeprazoleCytochrome P450 3A4enzyme
DB01129RabeprazoleCytochrome P450 2C19enzyme
DB01129RabeprazoleATP-binding cassette sub-family G member 2transporter
DB01129RabeprazoleCytochrome P450 1A1enzyme
DB01129RabeprazoleCytochrome P450 1A2enzyme
DB01129RabeprazoleCytochrome P450 2C9enzyme
DB01129RabeprazoleCytochrome P450 2D6enzyme
DB01129RabeprazoleCytochrome P450 2C8enzyme
DB00364SucralfateSerum albumincarrier
DB00364SucralfateFibrinogen alpha chaintarget
DB00364SucralfateFibrinogen beta chaintarget
DB00364SucralfateFibrinogen gamma chaintarget
DB00364SucralfatePepsintarget
DB00364SucralfatePro-epidermal growth factortarget
DB00364SucralfateFibroblast growth factor 2target
DrugDrug NamePhaseStatusCount
DB12770Lafutidine1Completed1
DB00338Omeprazole1Completed2
DB00788Naproxen1 / 2Completed1
DB01060Amoxicillin2 / 3Unknown Status1
DB01211Clarithromycin2 / 3Unknown Status1
DB00916Metronidazole2 / 3Unknown Status1
DB01129Rabeprazole2 / 3Unknown Status1
DB00945Acetylsalicylic acid3Completed2
DB01060Amoxicillin3Unknown Status1
DB00482Celecoxib3Completed1
DB01211Clarithromycin3Unknown Status1
DB00586Diclofenac3Terminated1
DB00736Esomeprazole3Completed7
DB00736Esomeprazole3Recruiting1
DB00736Esomeprazole3Terminated1
DB12079Gefarnate3Completed1
DB12079Gefarnate3Terminated1
DB00448Lansoprazole3Completed6
DB00448Lansoprazole3Recruiting1
DB00448Lansoprazole3Terminated1
DB00448Lansoprazole3Unknown Status1
DB00929Misoprostol3Terminated1
DB00788Naproxen3Completed3
DB00788Naproxen3Terminated1
DB00338Omeprazole3Completed3
DB00863Ranitidine3Completed1
DB11656Rebamipide3Completed1
DB11739Vonoprazan3Recruiting1
DB01060Amoxicillin4Recruiting1
DB04115Berberine4Recruiting1
DB01294Bismuth subsalicylate4Recruiting1
DB00736Esomeprazole4Completed1
DB00736Esomeprazole4Recruiting1
DB00614Furazolidone4Recruiting1
DB00448Lansoprazole4Completed1
DB00338Omeprazole4Completed1
DB01129Rabeprazole4Completed1
DB11656Rebamipide4Completed2
DB00759Tetracycline4Recruiting1
DB00213PantoprazoleNot AvailableCompleted1
DB11656RebamipideNot AvailableCompleted1