Hyperlipidemias

Also known as: Hyperlipidemia / Hyperlipemia / Hyperlipidaemia / Hyperlipaemia / Hyperlipidemia, unspecified / Lipidemia / Hyperlipidaemia NOS

DrugDrug NameDrug Description
DB00930ColesevelamColesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.
DB13751Glycyrrhizic acidGlycyrrhizic acid is extracted from the root of the licorice plant; _Glycyrrhiza glabra_.[F79] It is a triterpene glycoside with glycyrrhetinic acid that possesses a wide range of pharmacological and biological activities. When extracted from the plant, it can be obtained in the form of ammonium glycyrrhizin and mono-ammonium glycyrrhizin.[T204] Glycyrrhizic acid has been developed in Japan and China as a hepatoprotective drug in cases of chronic hepatitis.[A33062] From January 2014, glycyrrhizic acid as part of the licorice extract was approved by the FDA as an existing food sweetener.[F80] It was approved by Health Canada to be used in over-the-counter products but all the products are currently on the status canceled post marketed.[L1113]
DB00191PhenterminePhentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.[A174370] Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential).[A174367] Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to obtain the desired effect.[A174373]
DB00175PravastatinPravastatin is the 6-alpha-hydroxy acid form of [mevastatin].[T303] Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug.[T274] This drug was developed by Sankyo Co. Ltd.; however, the first approved pravastatin product was developed by Bristol Myers Squibb and FDA approved in 1991.[L6142] Pravastatin is made through a fermentation process in which [mevastatin] is first obtained. The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation with _Streptomyces carbophilus_ to introduce the allylic 6-alcohol group.[T239]
DrugDrug NameTargetType
DB00930ColesevelamBile acidstarget
DB13751Glycyrrhizic acidCorticosteroid 11-beta-dehydrogenase isozyme 1target
DB13751Glycyrrhizic acidAldo-keto reductase family 1 member C4carrier
DB13751Glycyrrhizic acidAldo-keto reductase family 1 member C3carrier
DB13751Glycyrrhizic acidAldo-keto reductase family 1 member C2carrier
DB13751Glycyrrhizic acidTumor necrosis factortarget
DB13751Glycyrrhizic acidCaspase-3target
DB13751Glycyrrhizic acidNuclear factor NF-kappa-Btarget
DB13751Glycyrrhizic acidLipoprotein lipasetarget
DB13751Glycyrrhizic acidSerum albumincarrier
DB13751Glycyrrhizic acidBile salt export pumptransporter
DB00191PhentermineSodium-dependent noradrenaline transportertarget
DB00191PhentermineSodium-dependent dopamine transportertarget
DB00191PhentermineAmine oxidase [flavin-containing] Atarget
DB00191PhentermineAmine oxidase [flavin-containing] Btarget
DB00191PhentermineSodium-dependent serotonin transportertarget
DB00191PhenterminePro-neuropeptide Ytarget
DB00191PhentermineCytochrome P450 3A4enzyme
DB00175Pravastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB00175PravastatinSolute carrier organic anion transporter family member 2B1transporter
DB00175PravastatinMultidrug resistance protein 1transporter
DB00175PravastatinSolute carrier organic anion transporter family member 1A2transporter
DB00175PravastatinSolute carrier family 22 member 6transporter
DB00175PravastatinSolute carrier family 22 member 8transporter
DB00175PravastatinCanalicular multispecific organic anion transporter 1transporter
DB00175PravastatinSolute carrier family 22 member 11transporter
DB00175PravastatinATP-binding cassette sub-family G member 2transporter
DB00175PravastatinSolute carrier family 22 member 7transporter
DB00175PravastatinSolute carrier organic anion transporter family member 1B1transporter
DB00175PravastatinMonocarboxylate transporter 1transporter
DB00175PravastatinBile salt export pumptransporter
DB00175PravastatinSolute carrier organic anion transporter family member 1B3transporter
DrugDrug NamePhaseStatusCount
DB00381Amlodipine1Completed4
DB00381Amlodipine1Recruiting1
DB00381Amlodipine1Terminated1
DB06630Anacetrapib1Completed1
DB01076Atorvastatin1Completed5
DB12456Bococizumab1Completed1
DB01264Darunavir1Unknown Status1
DB00625Efavirenz1Unknown Status1
DB09303Evolocumab1Completed2
DB00973Ezetimibe1Completed2
DB09279Fimasartan1Completed2
DB09237Levamlodipine1Completed2
DB00678Losartan1Completed1
DB00331Metformin1Completed1
DB00331Metformin1Recruiting1
DB00627Niacin1Completed1
DB08860Pitavastatin1Completed2
DB08860Pitavastatin1Unknown Status1
DB00175Pravastatin1Completed1
DB00503Ritonavir1Unknown Status1
DB01098Rosuvastatin1Completed8
DB01098Rosuvastatin1Recruiting2
DB01098Rosuvastatin1Terminated1
DB00641Simvastatin1Completed1
DB00966Telmisartan1Completed4
DB00966Telmisartan1Terminated1
DB00177Valsartan1Completed4
DB01076Atorvastatin1 / 2Terminated1
DB03128Acetylcholine2Terminated1
DB09302Alirocumab2Recruiting1
DB00381Amlodipine2Completed1
DB12326Antroquinonol2Active Not Recruiting1
DB01076Atorvastatin2Completed7
DB01076Atorvastatin2Terminated1
DB11936Bempedoic acid2Completed2
DB12126Bradykinin2Terminated1
DB11121Chloroxylenol2Completed1
DB09303Evolocumab2Completed3
DB00973Ezetimibe2Completed3
DB01039Fenofibrate2Completed2
DB00196Fluconazole2Terminated1
DB08827Lomitapide2Completed1
DB00678Losartan2Completed1
DB12390MBX-80252Completed1
DB05528Mipomersen2Completed3
DB00325Nitroprusside2Terminated1
DB00412Rosiglitazone2Completed1
DB01098Rosuvastatin2Completed2
DB05678SLx-40902Completed1
DB09153Sodium chloride2Terminated1
DB05317TAK-4752Completed1
DB10580Tea leaf2Terminated1
DB08837Tetraethylammonium2Terminated1
DB11815Tilarginine2Terminated1
DB01076Atorvastatin2 / 3Recruiting1
DB09341Dextrose, unspecified form2 / 3Not Yet Recruiting1
DB12116Epigallocatechin gallate2 / 3Unknown Status1
DB01098Rosuvastatin2 / 3Recruiting1
DB01261Sitagliptin2 / 3Completed1
DB08900Teduglutide2 / 3Not Yet Recruiting1
DB08900Teduglutide2 / 3Recruiting3
DB11815Tilarginine2 / 3Recruiting1
DB00381Amlodipine3Completed1
DB00381Amlodipine3Recruiting1
DB01072Atazanavir3Completed2
DB01076Atorvastatin3Completed16
DB01076Atorvastatin3Terminated3
DB01076Atorvastatin3Unknown Status1
DB11936Bempedoic acid3Completed1
DB12456Bococizumab3Completed5
DB00930Colesevelam3Completed1
DB11655Evacetrapib3Terminated1
DB09303Evolocumab3Completed5
DB09303Evolocumab3Recruiting1
DB00973Ezetimibe3Completed8
DB00973Ezetimibe3Terminated2
DB01039Fenofibrate3Completed5
DB01029Irbesartan3Completed1
DB11629Laropiprant3Completed1
DB00678Losartan3Completed1
DB09046Metreleptin3Enrolling by Invitation2
DB05528Mipomersen3Completed2
DB00627Niacin3Completed3
DB00627Niacin3Terminated1
DB00275Olmesartan3Recruiting1
DB08860Pitavastatin3Terminated2
DB08860Pitavastatin3Unknown Status1
DB00175Pravastatin3Completed1
DB01599Probucol3Completed1
DB06817Raltegravir3Completed1
DB00412Rosiglitazone3Completed1
DB01098Rosuvastatin3Completed4
DB01098Rosuvastatin3Recruiting1
DB01098Rosuvastatin3Unknown Status1
DB00641Simvastatin3Completed7
DB00641Simvastatin3Terminated2
DB01261Sitagliptin3Completed1
DB00966Telmisartan3Completed1
DB00966Telmisartan3Unknown Status1
DB00273Topiramate3Terminated1
DB06281Torcetrapib3Completed7
DB06281Torcetrapib3Terminated2
DB00177Valsartan3Completed1
DB00945Acetylsalicylic acid4Completed1
DB00945Acetylsalicylic acid4Unknown Status1
DB09302Alirocumab4Active Not Recruiting1
DB00381Amlodipine4Completed1
DB01238Aripiprazole4Completed1
DB01076Atorvastatin4Completed4
DB01076Atorvastatin4Recruiting2
DB01076Atorvastatin4Terminated1
DB04540Cholesterol4Completed1
DB00930Colesevelam4Completed2
DB00375Colestipol4Completed1
DB01264Darunavir4Completed1
DB00973Ezetimibe4Completed2
DB00973Ezetimibe4Unknown Status1
DB00973Ezetimibe4Withdrawn1
DB01039Fenofibrate4Active Not Recruiting1
DB01039Fenofibrate4Completed1
DB01039Fenofibrate4Unknown Status1
DB00279Liothyronine4Completed1
DB00227Lovastatin4Completed1
DB00627Niacin4Completed2
DB09539Omega-3-acid ethyl esters4Completed2
DB00175Pravastatin4Completed3
DB00175Pravastatin4Unknown Status1
DB00503Ritonavir4Completed1
DB01098Rosuvastatin4Active Not Recruiting1
DB01098Rosuvastatin4Completed4
DB01098Rosuvastatin4Unknown Status2
DB00641Simvastatin4Completed2
DB00641Simvastatin4Not Yet Recruiting1
DB00641Simvastatin4Unknown Status1
DB00641Simvastatin4Withdrawn1
DB09055AcipimoxNot AvailableCompleted1
DB00802AlfentanilNot AvailableRecruiting1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic AcidNot AvailableRecruiting1
DB01076AtorvastatinNot AvailableCompleted2
DB00559BosentanNot AvailableRecruiting1
DB01413CefepimeNot AvailableRecruiting1
DB01432CholestyramineNot AvailableCompleted1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB00930ColesevelamNot AvailableCompleted1
DB03756DoconexentNot AvailableCompleted1
DB00005EtanerceptNot AvailableTerminated1
DB01276ExenatideNot AvailableCompleted1
DB00973EzetimibeNot AvailableCompleted1
DB00973EzetimibeNot AvailableNot Yet Recruiting1
DB01039FenofibrateNot AvailableCompleted2
DB00828FosfomycinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB00159IcosapentNot AvailableCompleted1
DB00598LabetalolNot AvailableRecruiting1
DB08815LurasidoneNot AvailableRecruiting1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00607NafcillinNot AvailableRecruiting1
DB00627NiacinNot AvailableCompleted1
DB01115NifedipineNot AvailableRecruiting1
DB00334OlanzapineNot AvailableCompleted1
DB11133Omega-3 fatty acidsNot AvailableCompleted1
DB09539Omega-3-acid ethyl estersNot AvailableActive Not Recruiting1
DB09539Omega-3-acid ethyl estersNot AvailableCompleted1
DB01083OrlistatNot AvailableNot Yet Recruiting1
DB00497OxycodoneNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB08860PitavastatinNot AvailableUnknown Status1
DB00728RocuroniumNot AvailableRecruiting1
DB00658SevelamerNot AvailableRecruiting1
DB00641SimvastatinNot AvailableCompleted2
DB00641SimvastatinNot AvailableNot Yet Recruiting1
DB00421SpironolactoneNot AvailableRecruiting1
DB00300Tenofovir disoproxilNot AvailableCompleted1
DB00684TobramycinNot AvailableRecruiting1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00512VancomycinNot AvailableRecruiting1
DB01339VecuroniumNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1
DB09145WaterNot AvailableTerminated1
DB00246ZiprasidoneNot AvailableCompleted1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableRecruiting1