Identification

Name
Simeprevir
Accession Number
DB06290
Type
Small Molecule
Groups
Approved
Description

Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients [7]. Like all NS3/4A inhibitors, simeprevir is a serine protease inhibitor in similarity to Boceprevir and Telaprevir but is classified as a second generation protease inhibitor. This class of antiviral drugs were the first direct acting antivirals approved but are associated with lower cure rates than newer drugs. Broad use of simeprevir occurred when it was used in combination with a newer drug, Sofosbuvir. Inhibiting HCV NS3/4A protease in a potent and highly specific manner, simeprevir is a direct-acting antiviral agent against the hepatitis C virus. Since the viral protease NS3/4A complex is essential for cleaving the HCV encoded polyprotein into individual viral proteins facilitating replication [4], the drug blocks the viral replication process. It is shown to display synergistic effects with interferon-α and HCV NS5B inhibitor, and additive effects with ribavirin in HCV replicon cells [2]. Unlike first generation serine protease inhibitors, simprevir has a sightly different resistance profile where limited therapeutic efficacy of the drug is observed with NS3 Q80K polymorphic variants and simeprevir-specific amino acid position of 168 also results in higher treatment failure rates [3]. The observed prevalence of the N3 Q80K polymorphism was 30% in subjects infected with HCV genotype 1a and 0.5% in subjects infected with HCV genotype 1b [3].

According to 2017 American Association for the Study of Liver Diseases (AASLD) and 2015 consensus guidelines from the Canadian Association for the Study of the Liver (CASL), simeprevir can be used as first-line or second-line threapies for treatment-naïve patients as adjunct to sofosbuvir treatment for genotype 1 or PEG-Interferon/ribavirin combination therapy for genotype 1 or 4. The combination therapy of simeprevir and other antiviral agents are initiated in HCV-positive patients with the intent to cure, or achieve a sustained virologic response (SVR), after 12 weeks of daily therapy. SVR and eradication of HCV infection is associated with significant long-term health benefits including reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma, and reduced all-cause mortality [6].

Simeprevir was approved by the FDA in November 2014 and is marketed under the brand name Olysio as oral tablets. Administered once daily with food, 150mg simeprevir capsule is used in combination with Sofosbuvir in patients with HCV genotype 1 without cirrhosis for 12 week duration. In patients with HCV genotype 1 with compensated cirrhosis, the treatment is directed for 24 week duration. Sustained virologic response 12 weeks after planned end of treatment (SVR12) was achieved in 170/176 (97%) subjects without cirrhosis treated with 12 weeks simeprevir in combination with sofosbuvir (FDA Label). The overall SVR12 was 88% (44/50) in treatment-naïve patients with cirrhosis [7].

Simeprevir is also used in treatment of HCV genotype 4 patients with or without cirrhosis and is taken with Peginterferon alfa-2a and Ribavirin; this triple therapy allows shortening treatment duration from 48 weeks or longer to 12 or 24 weeks [3] depending on prior response status and presence of HIV-1 co-infection. Prior to initiation of treatment with Peginterferon alfa-2a and Ribavirin, screening for the presence of virus with the NS3 Q80K polymorphism is strongly recommended and if detected, alternative treatment should be considered instead to prevent therapeutic failure. The SVR12 was 83% (29/35) in treatment-naïve patients and 86% (19/22) in relapsing patients.

Structure
Thumb
Synonyms
Not Available
External IDs
TMC 435 / TMC 435350 / TMC-435 / TMC-435350 / TMC435
Product Ingredients
IngredientUNIICASInChI Key
Simeprevir sodium16U7H601841241946-89-3LLXQGDWGCCKOQP-OBABASCOSA-M
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
GalexosCapsule150 mgOralJanssen Pharmaceuticals2013-11-25Not applicableCanada
OlysioCapsule150 mgOralJanssen Cilag International Nv2014-05-14Not applicableEu
OlysioCapsule150 mgOralJanssen Cilag International Nv2014-05-14Not applicableEu
OlysioCapsule150 mg/1OralJanssen, Lp2013-11-22Not applicableUs
Categories
UNII
9WS5RD66HZ
CAS number
923604-59-5
Weight
Average: 749.939
Monoisotopic: 749.291690263
Chemical Formula
C38H47N5O7S2
InChI Key
JTZZSQYMACOLNN-VDWJNHBNSA-N
InChI
InChI=1S/C38H47N5O7S2/c1-21(2)30-20-51-35(40-30)29-18-32(26-13-14-31(49-5)22(3)33(26)39-29)50-24-16-27-28(17-24)36(45)43(4)15-9-7-6-8-10-23-19-38(23,41-34(27)44)37(46)42-52(47,48)25-11-12-25/h8,10,13-14,18,20-21,23-25,27-28H,6-7,9,11-12,15-17,19H2,1-5H3,(H,41,44)(H,42,46)/b10-8-/t23-,24-,27-,28-,38-/m1/s1
IUPAC Name
(1R,4R,6S,7Z,15R,17R)-N-(cyclopropanesulfonyl)-2-hydroxy-17-({7-methoxy-8-methyl-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-13-methyl-14-oxo-3,13-diazatricyclo[13.3.0.0⁴,⁶]octadeca-2,7-diene-4-carboximidic acid
SMILES
[H]\C1=C([H])\[[email protected]]2([H])C[[email protected]]2(N=C(O)[[email protected]]2([H])C[[email protected]]([H])(C[[email protected]@]2([H])C(=O)N(C)CCCC1)OC1=C2C=CC(OC)=C(C)C2=NC(=C1)C1=NC(=CS1)C(C)C)C(O)=NS(=O)(=O)C1CC1

Pharmacology

Indication

Indicated for the treatment of adults with chronic hepatitis C virus (HCV) infection: typically in combination with sofosbuvir in patients with HCV genotype 1 without cirrhosis or with compensated cirrhosis and in combination with peginterferon alfa (Peg-IFN-alfa) and ribavirin (RBV) in patients with HCV genotype 1 or 4 without cirrhosis or with compensated cirrhosis.

Resistance: Reduced susceptibility to simeprevir was most commonly associated with the viral NS3 Q80K polymorphism. Amino acid substitutions at NS3 positions S122, R155 and/or D168 are also shown to reduce susceptibility to simeprevir in genotype 1a/b patients.

Structured Indications
Pharmacodynamics

Simeprevir is a direct-acting antiviral agent and inhibitor for HCV NS3/4A protease, which is an important enzyme required for viral replication. Unlike Boceprevir and Telaprevir, simeprevir is a competitive, reversible, macrocyclic, noncovalent inhibitor. The macromolecular cyclic portion of the molecule improves the affnity and selectivity characteristics, which allows rapid association and slow dissociation to the protein target through noncovalent binding [3].

Mechanism of action

Simeprevir is accumulated in the liver after uptake into hepatocytes via OATP1B1/3. NS3/4A heterodimeric complex is composed of the cofactor N4A subunit and N3 subunit which contains the proteolytic site. The NS3/4A protease cleaves the HCV polyprotein downstream of the NS3 site, generating non-structural viral proteins NS3, NS4A, NS4B, NS5A and NS5A and subsequently formation of mature proteins [3, 4]. Simeprevir exerts an inhibitory action on HCV polyprotein cleavage via induced-fit binding to an extended S2 subsite located in the NS3 catalytic site [5]. NS3/4A inhibitors usually depend on few interactions located in the substrate binding groove of the viral serine protease, thus are susceptible to resistance and failed treatment from few critical mutations in these sites. At higher concentration above their antiviral half-maximal effective concentration (EC50), simeprevir and other NS3/4A inhibitors also restore interferon (IFN)-signaling pathways that are thought to be disrupted by NS3/4A protease and recover innate immune processes. NS3/4A protease cleaves two essential adaptor proteins that initiate signaling leading to activation of IFN regulatory factor 3 and IFN-α/β synthesis, which are mitochondrial antiviral-signaling proteins (MAVS otherwise known as IPS-1, VISA, or Cardif) and toll/interleukin-1 receptor (TIR)- domain-containing adaptor-inducing IFN-β (TRIF). Blocking the function of these adaptor proteins results in impaired interferon induction. NS3/4A inhibitors recover the proper IFN-signaling pathways [3, 4].

TargetActionsOrganism
ANS3 protease
inhibitor
Hepatitis C virus
Absorption

The mean absolute bioavailability of simeprevir following a single oral 150 mg dose of simeprevir capsule in fed conditions is 62%. Maximum plasma concentrations (Cmax) are typically achieved between 4 to 6 hours following the oral administration.

Volume of distribution

The volume of distribution for simeprevir has yet to be determined. In animal studies, simeprevir is extensively distributed to gut and liver (liver:blood ratio of 29:1 in rat) tissues.

Protein binding

Simeprevir is extensively (99.9%) bound to plasma proteins, mainly to albumin and to a lesser extent, alpha 1-acid glycoprotein. Increased plasma concentration due to drug-drug interactions is expected when co-administering moderate or strong inhibitors of CYP3A, while the opposite effect is predicted from co-administration of moderate or strong inducers of CYP3A.

Metabolism

Simeprevir undergoes hepatic metabolism. The primary metabolic pathway involves CYP3A system-mediated oxidation. Involvement of CYP2C8 and CYP2C19 cannot be excluded.

Route of elimination

Simeprevir is predominantly eliminated through biliary excretion. In a radioactivity study, 91% of radiolabeled drug was detected in the feces and less than 1% was detected in the urine. From the recovered drug in the feces, the unchanged form of simeprevir accounted for 31% of the total administered dose.

Half life

The elimination half-life of simeprevir following 200mg dose administration is about 41 hours in HCV-positive patients and 10 to 13 hours in individuals without HCV infection.

Clearance

The clearance of simeprevir has yet to be determined.

Toxicity

In a combination therapy with sofosbuvir, most common reported adverse effects is fatigue, headache and nausea. In case of triple therapy with PEG-Interferon Alfa-2A and ribavirin, most common adverse effects included rash (including photosensitivity), pruritus and nausea. Elevations of serum bilirubin may be observed due to inhibition of bilirubin transporters OATP1B1 and MRP2 by simeprevir.

Affected organisms
  • Hepatitis C Virus
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Simeprevir.Approved, Investigational
AbemaciclibThe serum concentration of Abemaciclib can be increased when it is combined with Simeprevir.Approved
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Simeprevir.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Simeprevir.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Simeprevir.Approved
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Simeprevir.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Simeprevir.Approved
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Simeprevir.Approved, Investigational
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Simeprevir.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Simeprevir.Approved
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Simeprevir.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Simeprevir.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Simeprevir.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Simeprevir.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Simeprevir.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Simeprevir.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Simeprevir.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Simeprevir.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Simeprevir.Approved, Investigational
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Simeprevir.Experimental, Investigational
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Simeprevir.Illicit, Withdrawn
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Simeprevir.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Simeprevir.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Simeprevir.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Simeprevir.Approved
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Simeprevir.Approved
AmoxapineThe serum concentration of Amoxapine can be increased when it is combined with Simeprevir.Approved
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Simeprevir.Approved
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Simeprevir.Approved
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Simeprevir.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Simeprevir.Approved
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Simeprevir.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Simeprevir.Approved, Investigational
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Simeprevir.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Simeprevir.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Simeprevir.Approved
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Simeprevir.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Simeprevir.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Simeprevir.Approved, Investigational
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Simeprevir.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Simeprevir.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Simeprevir.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Simeprevir.Approved
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Simeprevir.Approved
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Simeprevir.Investigational
BaricitinibThe serum concentration of Baricitinib can be increased when it is combined with Simeprevir.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Simeprevir.Approved
BendamustineThe metabolism of Bendamustine can be decreased when combined with Simeprevir.Approved, Investigational
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Simeprevir.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Simeprevir.Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Simeprevir.Approved
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Simeprevir.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Simeprevir.Approved
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Simeprevir.Approved
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Simeprevir.Approved
BlonanserinThe serum concentration of Blonanserin can be increased when it is combined with Simeprevir.Approved, Investigational
BoceprevirThe serum concentration of Simeprevir can be decreased when it is combined with Boceprevir.Approved, Withdrawn
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Simeprevir.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Simeprevir.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Simeprevir.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Simeprevir.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Simeprevir.Approved
BrigatinibThe serum concentration of Brigatinib can be increased when it is combined with Simeprevir.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Simeprevir.Approved
BrivaracetamThe serum concentration of Brivaracetam can be increased when it is combined with Simeprevir.Approved, Investigational
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Simeprevir.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Simeprevir.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Simeprevir.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Simeprevir.Approved
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Simeprevir.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Simeprevir.Approved
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Simeprevir.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Simeprevir.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Simeprevir.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Simeprevir.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Simeprevir.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Simeprevir.Approved
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Simeprevir.Approved, Nutraceutical
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Simeprevir.Approved
CannabidiolThe serum concentration of Cannabidiol can be increased when it is combined with Simeprevir.Approved, Investigational
CarbamazepineThe metabolism of Simeprevir can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Simeprevir.Approved
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Simeprevir.Approved
CarmustineThe metabolism of Carmustine can be decreased when combined with Simeprevir.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Simeprevir.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Simeprevir.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Simeprevir.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Simeprevir.Approved, Vet Approved
CeritinibThe serum concentration of Simeprevir can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Simeprevir.Withdrawn
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Simeprevir.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Simeprevir.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Simeprevir.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Simeprevir.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Simeprevir.Investigational, Withdrawn
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Simeprevir.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Simeprevir.Approved, Vet Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Simeprevir.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Simeprevir.Approved, Nutraceutical
Cholic AcidSimeprevir may decrease the excretion rate of Cholic Acid which could result in a higher serum level.Approved
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Simeprevir.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Simeprevir.Approved
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Simeprevir.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Simeprevir.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Simeprevir.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Simeprevir.Approved
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Simeprevir.Approved
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Simeprevir.Approved, Investigational, Vet Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Simeprevir.Approved
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Simeprevir.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Simeprevir.Approved, Illicit
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Simeprevir.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Simeprevir.Approved, Investigational
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Simeprevir.Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Simeprevir.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Simeprevir.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Simeprevir.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Simeprevir.Approved
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Simeprevir.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Simeprevir.Approved, Illicit
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Simeprevir.Approved
CobicistatThe serum concentration of Simeprevir can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Simeprevir.Approved
CocaineThe serum concentration of Cocaine can be increased when it is combined with Simeprevir.Approved, Illicit
CodeineThe serum concentration of Codeine can be increased when it is combined with Simeprevir.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Simeprevir.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Simeprevir.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be increased when it is combined with Simeprevir.Approved
CopanlisibThe serum concentration of Copanlisib can be increased when it is combined with Simeprevir.Approved
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Simeprevir.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Simeprevir.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Simeprevir.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Simeprevir.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Simeprevir.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Simeprevir.Approved
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Simeprevir.Approved
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Simeprevir.Approved, Investigational
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Simeprevir.Approved
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Simeprevir.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Simeprevir.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Simeprevir.Investigational
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Simeprevir.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Simeprevir.Approved, Investigational
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Simeprevir.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Simeprevir.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Simeprevir.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Simeprevir.Approved
DeflazacortThe serum concentration of Deflazacort can be increased when it is combined with Simeprevir.Approved, Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Simeprevir.Approved
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Simeprevir.Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Simeprevir.Approved
DeutetrabenazineThe serum concentration of Deutetrabenazine can be increased when it is combined with Simeprevir.Approved, Investigational
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
Dexchlorpheniramine maleateThe serum concentration of Dexchlorpheniramine maleate can be increased when it is combined with Simeprevir.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Simeprevir.Approved, Illicit, Investigational, Withdrawn
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Simeprevir.Approved, Investigational
DexlansoprazoleThe serum concentration of Dexlansoprazole can be increased when it is combined with Simeprevir.Approved
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Simeprevir.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational, Withdrawn
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Simeprevir.Approved, Illicit, Vet Approved
DibenzepinThe serum concentration of Dibenzepin can be increased when it is combined with Simeprevir.Experimental
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Simeprevir.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Simeprevir.Approved, Investigational
DienogestThe serum concentration of Dienogest can be increased when it is combined with Simeprevir.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Simeprevir.Approved, Investigational
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Simeprevir.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Simeprevir.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Simeprevir.Approved, Illicit
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Simeprevir.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Simeprevir.Approved, Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Simeprevir.Experimental
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Simeprevir.Approved
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Simeprevir.Approved
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Simeprevir.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Simeprevir.Approved
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Simeprevir.Approved
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Simeprevir.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Simeprevir.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Simeprevir.Approved
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Simeprevir.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Simeprevir.Approved
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Simeprevir.Approved
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Simeprevir.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Simeprevir.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Simeprevir.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Simeprevir.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Simeprevir.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Simeprevir.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Simeprevir.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Simeprevir.Approved
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Simeprevir.Approved, Investigational
ElbasvirThe serum concentration of Elbasvir can be increased when it is combined with Simeprevir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Simeprevir.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Simeprevir.Approved
EltrombopagThe serum concentration of Simeprevir can be increased when it is combined with Eltrombopag.Approved
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Simeprevir.Approved
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Simeprevir.Approved, Vet Approved
EnasidenibThe serum concentration of Enasidenib can be increased when it is combined with Simeprevir.Approved
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Simeprevir.Approved, Investigational
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Simeprevir.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Simeprevir.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Simeprevir.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Simeprevir.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Simeprevir.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Simeprevir.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Simeprevir.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Simeprevir.Approved, Investigational
ErythromycinThe serum concentration of Simeprevir can be increased when it is combined with Erythromycin.Approved, Vet Approved
EscitalopramThe serum concentration of Simeprevir can be decreased when it is combined with Escitalopram.Approved, Investigational
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Simeprevir.Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Simeprevir.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Simeprevir.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
Estradiol acetateThe serum concentration of Estradiol acetate can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
Estradiol benzoateThe serum concentration of Estradiol benzoate can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
Estradiol cypionateThe serum concentration of Estradiol cypionate can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
Estradiol dienanthateThe serum concentration of Estradiol dienanthate can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
Estradiol valerateThe serum concentration of Estradiol valerate can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Simeprevir.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be increased when it is combined with Simeprevir.Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Simeprevir.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Simeprevir.Approved
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Simeprevir.Approved
EthanolThe serum concentration of Ethanol can be increased when it is combined with Simeprevir.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Simeprevir.Approved
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Simeprevir.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Simeprevir.Approved, Illicit
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Simeprevir.Approved
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Simeprevir.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Simeprevir.Approved
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Simeprevir.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Simeprevir.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Simeprevir.Approved
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Simeprevir.Approved, Investigational
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Simeprevir.Approved
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Simeprevir.Approved
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Simeprevir.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Simeprevir.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Simeprevir.Approved
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Simeprevir.Approved
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Simeprevir.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Simeprevir.Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Simeprevir.Approved
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Simeprevir.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Simeprevir.Approved, Illicit
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Simeprevir.Approved
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Simeprevir.Approved
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Simeprevir.Approved, Vet Approved
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Simeprevir.Approved, Illicit
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Simeprevir.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Simeprevir.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Simeprevir.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Simeprevir.Approved
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Simeprevir.Approved, Investigational
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Simeprevir.Approved
FosphenytoinThe serum concentration of Simeprevir can be decreased when it is combined with Fosphenytoin.Approved
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Simeprevir.Approved, Investigational
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Simeprevir.Approved, Investigational
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Simeprevir.Approved
GarlicThe serum concentration of Simeprevir can be decreased when it is combined with Garlic.Approved
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Simeprevir.Approved, Investigational
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Simeprevir.Approved
GenisteinThe metabolism of Genistein can be decreased when combined with Simeprevir.Investigational
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Simeprevir.Approved
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Simeprevir.Approved
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Simeprevir.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Simeprevir.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Simeprevir.Investigational, Withdrawn
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Simeprevir.Approved, Investigational
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Simeprevir.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Simeprevir.Approved
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Simeprevir.Approved
HalothaneThe serum concentration of Halothane can be increased when it is combined with Simeprevir.Approved, Vet Approved
HesperetinThe metabolism of Hesperetin can be decreased when combined with Simeprevir.Approved
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Simeprevir.Withdrawn
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Simeprevir.Approved
HistamineThe serum concentration of Histamine can be increased when it is combined with Simeprevir.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Simeprevir.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Simeprevir.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Simeprevir.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Simeprevir.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Simeprevir.Approved
IcotinibThe serum concentration of Icotinib can be increased when it is combined with Simeprevir.Approved, Investigational
IdelalisibThe serum concentration of Simeprevir can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Simeprevir.Approved
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Simeprevir.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Simeprevir.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Simeprevir.Approved, Investigational
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Simeprevir.Approved
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Simeprevir.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Simeprevir.Approved
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Simeprevir.Approved
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Simeprevir.Approved
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Simeprevir.Approved
IprindoleThe serum concentration of Iprindole can be increased when it is combined with Simeprevir.Experimental
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Simeprevir.Approved, Investigational
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Simeprevir.Approved, Investigational
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Simeprevir.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Simeprevir.Approved
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Simeprevir.Approved
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Simeprevir.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Simeprevir.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Simeprevir.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Simeprevir.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Simeprevir.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Simeprevir.Approved
KetamineThe serum concentration of Ketamine can be increased when it is combined with Simeprevir.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Simeprevir.Approved
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Simeprevir.Approved, Investigational
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Simeprevir.Approved, Investigational
LacidipineThe serum concentration of Lacidipine can be increased when it is combined with Simeprevir.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Simeprevir.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Simeprevir.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Simeprevir.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Simeprevir.Approved
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Simeprevir.Approved, Investigational
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Simeprevir.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Simeprevir.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Simeprevir.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Simeprevir.Approved, Investigational
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Simeprevir.Approved
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Simeprevir.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Simeprevir.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Simeprevir.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Simeprevir.Approved
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Simeprevir.Approved, Vet Approved
LisurideThe serum concentration of Lisuride can be increased when it is combined with Simeprevir.Approved, Investigational
LofepramineThe serum concentration of Lofepramine can be increased when it is combined with Simeprevir.Experimental
LomefloxacinThe metabolism of Lomefloxacin can be decreased when combined with Simeprevir.Approved, Investigational
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Simeprevir.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Simeprevir.Approved
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Simeprevir.Approved
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Simeprevir.Approved
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Simeprevir.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Simeprevir.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Simeprevir.Approved, Investigational
LumacaftorThe serum concentration of Simeprevir can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Simeprevir.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Simeprevir.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Simeprevir.Approved
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Simeprevir.Illicit, Investigational, Withdrawn
MacimorelinThe serum concentration of Macimorelin can be increased when it is combined with Simeprevir.Approved, Investigational
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Simeprevir.Approved
MalathionThe metabolism of Malathion can be decreased when combined with Simeprevir.Approved, Investigational
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Simeprevir.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Simeprevir.Approved, Investigational
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Simeprevir.Approved, Vet Approved
MecamylamineThe risk or severity of adverse effects can be increased when Simeprevir is combined with Mecamylamine.Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Simeprevir.Approved, Investigational
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Simeprevir.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Simeprevir.Approved, Nutraceutical, Vet Approved
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Simeprevir.Approved, Vet Approved
MenadioneThe metabolism of Menadione can be decreased when combined with Simeprevir.Approved, Nutraceutical
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Simeprevir.Investigational, Withdrawn
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Simeprevir.Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Simeprevir.Experimental
MethadoneThe serum concentration of Methadone can be increased when it is combined with Simeprevir.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Simeprevir.Experimental
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Simeprevir.Illicit, Withdrawn
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Simeprevir.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Simeprevir.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Simeprevir.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Simeprevir.Approved
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Simeprevir.Approved
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Simeprevir.Approved
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Simeprevir.Experimental
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Simeprevir.Approved
MianserinThe serum concentration of Mianserin can be increased when it is combined with Simeprevir.Approved, Investigational
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Simeprevir.Investigational, Withdrawn
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Simeprevir.Approved, Illicit
MidostaurinThe serum concentration of Midostaurin can be increased when it is combined with Simeprevir.Approved
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Simeprevir.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Simeprevir.Approved
MirodenafilThe serum concentration of Mirodenafil can be increased when it is combined with Simeprevir.Investigational
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Simeprevir.Approved
MitotaneThe serum concentration of Simeprevir can be decreased when it is combined with Mitotane.Approved
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Simeprevir.Approved, Investigational
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Simeprevir.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Simeprevir.Approved, Investigational
MuraglitazarThe metabolism of Muraglitazar can be decreased when combined with Simeprevir.Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Simeprevir.Approved, Investigational
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Simeprevir.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Simeprevir.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Simeprevir.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Simeprevir.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Simeprevir.Approved, Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Simeprevir.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Simeprevir.Approved
NeratinibThe serum concentration of Neratinib can be increased when it is combined with Simeprevir.Approved, Investigational
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Simeprevir.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Simeprevir.Approved
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Simeprevir.Approved, Investigational
NicotineThe serum concentration of Nicotine can be increased when it is combined with Simeprevir.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Simeprevir.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Simeprevir.Approved, Investigational
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Simeprevir.Approved, Investigational
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Simeprevir.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Simeprevir.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Simeprevir.Approved
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Simeprevir.Approved
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Simeprevir.Approved, Investigational
Nitric OxideThe metabolism of Nitric Oxide can be decreased when combined with Simeprevir.Approved
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Simeprevir.Approved
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Simeprevir.Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Simeprevir.Approved
OdanacatibThe serum concentration of Odanacatib can be increased when it is combined with Simeprevir.Investigational
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Simeprevir.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Simeprevir.Approved
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Simeprevir.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Simeprevir.Approved
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Simeprevir.Investigational
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Simeprevir.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Simeprevir.Approved
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Simeprevir.Approved, Investigational
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Simeprevir.Approved
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Simeprevir.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Simeprevir.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Simeprevir is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Simeprevir.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Simeprevir.Approved
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Simeprevir.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Simeprevir.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Simeprevir.Approved
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Simeprevir.Approved
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Simeprevir.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Simeprevir.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Simeprevir.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Simeprevir.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Simeprevir.Approved
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Simeprevir.Approved
PentobarbitalThe serum concentration of Simeprevir can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Simeprevir.Approved, Investigational
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Simeprevir.Approved
PergolideThe serum concentration of Pergolide can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Simeprevir.Approved, Investigational
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Simeprevir.Approved, Investigational
PerospironeThe serum concentration of Perospirone can be increased when it is combined with Simeprevir.Approved
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Simeprevir.Approved
PethidineThe risk or severity of adverse effects can be increased when Simeprevir is combined with Pethidine.Approved
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Simeprevir.Withdrawn
PhenobarbitalThe serum concentration of Simeprevir can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Simeprevir.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Simeprevir.Approved, Investigational
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Simeprevir.Approved, Vet Approved
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Simeprevir.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Simeprevir.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Simeprevir.Approved
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Simeprevir.Withdrawn
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Simeprevir.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Simeprevir.Approved, Investigational
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Simeprevir.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Simeprevir.Approved
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Simeprevir.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Simeprevir.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Simeprevir.Approved
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be increased when it is combined with Simeprevir.Approved, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Simeprevir.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Simeprevir.Approved
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Simeprevir.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Simeprevir.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Simeprevir.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Simeprevir.Approved, Vet Approved
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Simeprevir.Approved
PrimidoneThe serum concentration of Simeprevir can be decreased when it is combined with Primidone.Approved, Vet Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Simeprevir.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Simeprevir.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Simeprevir.Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Simeprevir.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Simeprevir.Approved
PropofolThe serum concentration of Propofol can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
Propoxyphene napsylateThe serum concentration of Propoxyphene napsylate can be increased when it is combined with Simeprevir.Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Simeprevir.Approved, Investigational
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Simeprevir.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Simeprevir.Approved
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Simeprevir.Approved
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Simeprevir.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Simeprevir.Approved
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Simeprevir.Approved, Investigational
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Simeprevir.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Simeprevir.Approved
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Simeprevir.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Simeprevir.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Simeprevir.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Simeprevir.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Simeprevir.Approved, Investigational
RasagilineThe metabolism of Rasagiline can be decreased when combined with Simeprevir.Approved
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Simeprevir.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Simeprevir.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Simeprevir.Approved, Investigational
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Simeprevir.Approved, Experimental, Investigational
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Simeprevir.Approved
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Simeprevir.Approved
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Simeprevir.Approved
RifapentineThe serum concentration of Simeprevir can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Simeprevir.Approved, Investigational
RilpivirineThe serum concentration of Simeprevir can be increased when it is combined with Rilpivirine.Approved
RiluzoleThe metabolism of Riluzole can be decreased when combined with Simeprevir.Approved, Investigational
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Simeprevir.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Simeprevir.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Simeprevir.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Simeprevir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Simeprevir.Approved
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Simeprevir.Approved
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Simeprevir.Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Simeprevir.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Simeprevir.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Simeprevir.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Simeprevir.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Simeprevir.Approved
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Simeprevir.Approved
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Simeprevir.Approved, Investigational, Withdrawn
RucaparibThe serum concentration of Rucaparib can be increased when it is combined with Simeprevir.Approved, Investigational
RupatadineThe serum concentration of Rupatadine can be increased when it is combined with Simeprevir.Approved
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Simeprevir.Approved
SafinamideThe serum concentration of Safinamide can be increased when it is combined with Simeprevir.Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Simeprevir.Approved
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Simeprevir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Simeprevir.Approved
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Simeprevir.Approved
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Simeprevir.Approved
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Simeprevir.Approved, Investigational, Withdrawn
SertralineThe serum concentration of Sertraline can be increased when it is combined with Simeprevir.Approved
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Simeprevir.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Simeprevir.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Simeprevir.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Simeprevir.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Simeprevir.Approved, Investigational
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Simeprevir.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Simeprevir.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Simeprevir.Approved, Investigational
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Simeprevir.Approved
St. John's WortThe serum concentration of Simeprevir can be decreased when it is combined with St. John's Wort.Investigational, Nutraceutical
StiripentolThe serum concentration of Simeprevir can be increased when it is combined with Stiripentol.Approved
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Simeprevir.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Simeprevir.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Simeprevir.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Simeprevir.Approved
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Simeprevir.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Simeprevir.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Simeprevir.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Simeprevir.Approved
TacrineThe metabolism of Tacrine can be decreased when combined with Simeprevir.Investigational, Withdrawn
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Simeprevir.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Simeprevir.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Simeprevir.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Simeprevir.Approved, Investigational
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Simeprevir.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Simeprevir.Experimental
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Simeprevir.Approved, Withdrawn
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Simeprevir.Approved
TemafloxacinThe metabolism of Temafloxacin can be decreased when combined with Simeprevir.Withdrawn
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Simeprevir.Approved
TemsirolimusThe risk or severity of adverse effects can be increased when Simeprevir is combined with Temsirolimus.Approved
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Simeprevir.Approved
Tenofovir disoproxilThe serum concentration of Simeprevir can be decreased when it is combined with Tenofovir disoproxil.Approved, Investigational
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Simeprevir.Withdrawn
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Simeprevir.Experimental
TeriflunomideThe serum concentration of Simeprevir can be increased when it is combined with Teriflunomide.Approved
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Simeprevir.Investigational
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Simeprevir.Approved, Investigational
Testosterone CypionateThe serum concentration of Testosterone Cypionate can be increased when it is combined with Simeprevir.Approved, Investigational
Testosterone EnanthateThe serum concentration of Testosterone Enanthate can be increased when it is combined with Simeprevir.Approved, Investigational
Testosterone UndecanoateThe serum concentration of Testosterone Undecanoate can be increased when it is combined with Simeprevir.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Simeprevir.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Simeprevir.Approved, Investigational, Withdrawn
TheobromineThe metabolism of Theobromine can be decreased when combined with Simeprevir.Approved, Investigational
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Simeprevir.Approved
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Simeprevir.Approved, Vet Approved
ThioridazineThe metabolism of Thioridazine can be decreased when combined with Simeprevir.Approved, Withdrawn
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Simeprevir.Approved
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Simeprevir.Approved
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Simeprevir.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Simeprevir.Approved, Investigational
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Simeprevir.Approved
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Simeprevir.Approved
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Simeprevir.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Simeprevir.Approved
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Simeprevir.Approved, Investigational
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Simeprevir.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Simeprevir.Approved, Investigational
TolperisoneThe metabolism of Tolperisone can be decreased when combined with Simeprevir.Approved, Investigational
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Simeprevir.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Simeprevir.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Simeprevir.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Simeprevir.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Simeprevir.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Simeprevir.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Simeprevir.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Simeprevir.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Simeprevir.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Simeprevir.Approved, Vet Approved
TriamtereneThe metabolism of Triamterene can be decreased when combined with Simeprevir.Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Simeprevir.Approved
TrifluoperazineThe metabolism of Trifluoperazine can be decreased when combined with Simeprevir.Approved
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Simeprevir.Approved
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Simeprevir.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Simeprevir.Approved
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Simeprevir.Investigational, Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Simeprevir.Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Simeprevir.Approved, Investigational, Nutraceutical
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Simeprevir.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Simeprevir.Approved
VadimezanThe metabolism of Vadimezan can be decreased when combined with Simeprevir.Investigational
ValbenazineThe serum concentration of Valbenazine can be increased when it is combined with Simeprevir.Approved, Investigational
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Simeprevir.Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Simeprevir.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Simeprevir.Approved
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Simeprevir.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Simeprevir.Approved
VelpatasvirThe serum concentration of Velpatasvir can be increased when it is combined with Simeprevir.Approved
VemurafenibThe serum concentration of Simeprevir can be increased when it is combined with Vemurafenib.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Simeprevir.Approved
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Simeprevir.Approved
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Simeprevir.Approved
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Simeprevir.Investigational
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Simeprevir.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Simeprevir.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Simeprevir.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Simeprevir.Approved, Investigational
VincristineThe excretion of Vincristine can be decreased when combined with Simeprevir.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Simeprevir.Approved, Investigational
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Simeprevir.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Simeprevir.Approved
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Simeprevir.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Simeprevir.Approved
VoxilaprevirThe serum concentration of Voxilaprevir can be increased when it is combined with Simeprevir.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Simeprevir.Approved
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Simeprevir.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Simeprevir.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Simeprevir.Approved, Investigational
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Simeprevir.Approved
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Simeprevir.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Simeprevir.Approved
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Simeprevir.Approved, Investigational
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Simeprevir.Approved
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Simeprevir.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Simeprevir.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Simeprevir.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Simeprevir.Approved, Investigational
Food Interactions
  • Simeprevir should be taken with food.

References

Synthesis Reference

Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wahling H, Wickstrom K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K: Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24.

General References
  1. Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wahling H, Wickstrom K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K: Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24. [PubMed:18678486]
  2. Kanda T, Nakamoto S, Wu S, Yokosuka O: New treatments for genotype 1 chronic hepatitis C - focus on simeprevir. Ther Clin Risk Manag. 2014 May 24;10:387-94. doi: 10.2147/TCRM.S50170. eCollection 2014. [PubMed:24920913]
  3. Izquierdo L, Helle F, Francois C, Castelain S, Duverlie G, Brochot E: Simeprevir for the treatment of hepatitis C virus infection. Pharmgenomics Pers Med. 2014 Aug 14;7:241-9. doi: 10.2147/PGPM.S52715. eCollection 2014. [PubMed:25206310]
  4. Ahmed A, Felmlee DJ: Mechanisms of Hepatitis C Viral Resistance to Direct Acting Antivirals. Viruses. 2015 Dec 18;7(12):6716-29. doi: 10.3390/v7122968. [PubMed:26694454]
  5. Cummings MD, Lindberg J, Lin TI, de Kock H, Lenz O, Lilja E, Fellander S, Baraznenok V, Nystrom S, Nilsson M, Vrang L, Edlund M, Rosenquist A, Samuelsson B, Raboisson P, Simmen K: Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target. Angew Chem Int Ed Engl. 2010 Feb 22;49(9):1652-5. doi: 10.1002/anie.200906696. [PubMed:20166108]
  6. Myers RP, Shah H, Burak KW, Cooper C, Feld JJ: An update on the management of chronic hepatitis C: 2015 Consensus guidelines from the Canadian Association for the Study of the Liver. Can J Gastroenterol Hepatol. 2015 Jan-Feb;29(1):19-34. Epub 2015 Jan 13. [PubMed:25585348]
  7. American Association for the Study of Liver Diseases; Infectious Diseases Society of America. HCV guidance. http://hcvguidelines.org. Accessed June 12, 2017. [Link]
External Links
KEGG Drug
D10081
PubChem Compound
24873435
PubChem Substance
175427067
ChemSpider
23331536
BindingDB
50336504
ChEBI
134743
ChEMBL
CHEMBL501849
HET
30B
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Simeprevir
ATC Codes
J05AE14 — SimeprevirG01AE10 — Combinations of sulfonamides
AHFS Codes
  • 08:18.40.20 — HCV Protease Inhibitors
PDB Entries
3kee
FDA label
Download (1.31 MB)
MSDS
Download (57.5 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedOtherHealthy Volunteers2
1CompletedTreatmentChronic Hepatitis C Infection5
1CompletedTreatmentChronic Hepatitis C Infection / Viruses1
1CompletedTreatmentChronic Hepatitis C Virus (HCV) Infection1
1CompletedTreatmentHealthy Male Participants1
1CompletedTreatmentHealthy Participants1
1CompletedTreatmentHealthy Volunteers7
1CompletedTreatmentHepatitis C Virus (HCV)12
1CompletedTreatmentHepatitis C, Chronic1
1TerminatedTreatmentHealthy Volunteers1
2Active Not RecruitingTreatmentChronic Hepatitis C Virus (HCV) Infection1
2Active Not RecruitingTreatmentHepatitis C, Chronic2
2CompletedNot AvailableHepatitis C, Chronic1
2CompletedTreatmentChronic Hepatitis C Infection6
2CompletedTreatmentChronic Hepatitis C Virus1
2CompletedTreatmentChronic Hepatitis C Virus (HCV) Infection2
2CompletedTreatmentHepatitis C Virus (HCV)2
2CompletedTreatmentHepatitis C, Chronic5
2CompletedTreatmentHepatitits C1
2RecruitingTreatmentChronic Hepatitis C Infection1
2WithdrawnTreatmentEnd-Stage Renal Disease (ESRD) / Impaired Renal Function1
3CompletedTreatmentChronic Hepatitis C Infection6
3CompletedTreatmentChronic Hepatitis C Virus (HCV) Infection / Genotype 4 Chronic Hepatitis C1
3CompletedTreatmentHepatitis C Virus Genotype-11
3CompletedTreatmentHepatitis C Virus Infection2
3CompletedTreatmentHepatitis C, Chronic5
3CompletedTreatmentHepatitis C, Chronic / Infection NOS1
3RecruitingTreatmentHepatitis C, Chronic / Hepatocellular,Carcinoma1
4CompletedTreatmentChronic Hepatitis C Infection1
4CompletedTreatmentChronic Hepatitis C Virus (HCV) Infection1
4CompletedTreatmentHepatitis C, Chronic1
4RecruitingTreatmentChronic Hepatitis C Infection1
4WithdrawnTreatmentHepatitis C, Chronic / HIV CDC Category A11
4WithdrawnTreatmentPT-NANBH1
Not AvailableActive Not RecruitingNot AvailableChronic Hepatitis C Virus (HCV) Infection / Liver Cirrhosis1
Not AvailableCompletedOtherChronic Hepatitis C Infection / Human Immunodeficiency Virus (HIV)1
Not AvailableRecruitingNot AvailableChronic Hepatitis C Infection2
Not AvailableRecruitingNot AvailableHepatitis C, Chronic / Human Immunodeficiency Virus (HIV)1
Not AvailableTerminatedNot AvailableHepatitis C, Chronic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CapsuleOral150 mg
CapsuleOral150 mg/1
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US8349869No2006-07-282026-07-28Us
US8148399No2009-09-052029-09-05Us
US8754106No2006-07-282026-07-28Us
US8741926No2006-07-282026-07-28Us
US9040562No2006-07-282026-07-28Us
US7671032No2005-05-192025-05-19Us
US9623022No2006-07-282026-07-28Us
US9353103No2006-07-282026-07-28Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)225MSDS
water solubilityInsolubleFDA Label
Predicted Properties
PropertyValueSource
Water Solubility0.00458 mg/mLALOGPS
logP4.82ALOGPS
logP5.74ChemAxon
logS-5.2ALOGPS
pKa (Strongest Acidic)5.87ChemAxon
pKa (Strongest Basic)1.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count11ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area163.87 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity207.79 m3·mol-1ChemAxon
Polarizability80.18 Å3ChemAxon
Number of Rings7ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Macrolactams
Sub Class
Not Available
Direct Parent
Macrolactams
Alternative Parents
Alpha amino acid amides / Quinolines and derivatives / Anisoles / 2,4-disubstituted thiazoles / Alkyl aryl ethers / Pyridines and derivatives / Cyclopropanecarboxylic acids and derivatives / Tertiary carboxylic acid amides / Organosulfonic acids and derivatives / Aminosulfonyl compounds
show 9 more
Substituents
Macrolactam / Alpha-amino acid amide / Alpha-amino acid or derivatives / Quinoline / Anisole / 2,4-disubstituted 1,3-thiazole / Alkyl aryl ether / Cyclopropanecarboxylic acid or derivatives / Pyridine / Benzenoid
show 25 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Hepatitis C virus
Pharmacological action
Yes
Actions
Inhibitor
General Function
Serine-type peptidase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q91RS4
Uniprot Name
NS3 protease
Molecular Weight
19113.77 Da
References
  1. Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wahling H, Wickstrom K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K: Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24. [PubMed:18678486]

Enzymes

Kind
Protein group
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...

Components:
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da

Carriers

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Binder
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostagland...
Gene Name
SLCO1B1
Uniprot ID
Q9Y6L6
Uniprot Name
Solute carrier organic anion transporter family member 1B1
Molecular Weight
76447.99 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotre...
Gene Name
SLCO1B3
Uniprot ID
Q9NPD5
Uniprot Name
Solute carrier organic anion transporter family member 1B3
Molecular Weight
77402.175 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Organic anion transmembrane transporter activity
Specific Function
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name
ABCC2
Uniprot ID
Q92887
Uniprot Name
Canalicular multispecific organic anion transporter 1
Molecular Weight
174205.64 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both fro...
Gene Name
ABCG2
Uniprot ID
Q9UNQ0
Uniprot Name
ATP-binding cassette sub-family G member 2
Molecular Weight
72313.47 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name
SLCO2B1
Uniprot ID
O94956
Uniprot Name
Solute carrier organic anion transporter family member 2B1
Molecular Weight
76709.98 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Virus receptor activity
Specific Function
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presenc...
Gene Name
SLC10A1
Uniprot ID
Q14973
Uniprot Name
Sodium/bile acid cotransporter
Molecular Weight
38118.64 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Transporter activity
Specific Function
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name
ABCB11
Uniprot ID
O95342
Uniprot Name
Bile salt export pump
Molecular Weight
146405.83 Da

Drug created on March 19, 2008 10:22 / Updated on January 15, 2018 08:56