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Identification
NameSimeprevir
Accession NumberDB06290
TypeSmall Molecule
GroupsApproved
DescriptionSimeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis as a combination therapy, which includes peginterferon alfa and ribavirin. It was approved by the FDA in November 2014 and is marketed under the brand name Olysio.
Structure
Thumb
SynonymsNot Available
External Identifiers
  • TMC 435
  • TMC 435350
  • TMC-435
  • TMC-435350
  • TMC435
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
GalexosCapsule150 mgOralJanssen Inc2013-11-25Not applicableCanada
OlysioCapsule150 mgOralJanssen Cilag International N.V.2014-05-14Not applicableEu
OlysioCapsule150 mgOralJanssen Cilag International N.V.2014-05-14Not applicableEu
OlysioCapsule150 mg/1OralJanssen Products LP2013-11-22Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Simeprevir sodium
1241946-89-3
Thumb
  • InChI Key: LLXQGDWGCCKOQP-OBABASCOSA-M
  • Monoisotopic Mass: 771.27363547
  • Average Mass: 771.92
DBSALT001485
Categories
UNII9WS5RD66HZ
CAS number923604-59-5
WeightAverage: 749.939
Monoisotopic: 749.291690263
Chemical FormulaC38H47N5O7S2
InChI KeyJTZZSQYMACOLNN-VDWJNHBNSA-N
InChI
InChI=1S/C38H47N5O7S2/c1-21(2)30-20-51-35(40-30)29-18-32(26-13-14-31(49-5)22(3)33(26)39-29)50-24-16-27-28(17-24)36(45)43(4)15-9-7-6-8-10-23-19-38(23,41-34(27)44)37(46)42-52(47,48)25-11-12-25/h8,10,13-14,18,20-21,23-25,27-28H,6-7,9,11-12,15-17,19H2,1-5H3,(H,41,44)(H,42,46)/b10-8-/t23-,24-,27-,28-,38-/m1/s1
IUPAC Name
(1R,4R,6S,7Z,15R,17R)-N-(cyclopropanesulfonyl)-2-hydroxy-17-({7-methoxy-8-methyl-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-13-methyl-14-oxo-3,13-diazatricyclo[13.3.0.0⁴,⁶]octadeca-2,7-diene-4-carboximidic acid
SMILES
[H]\C1=C([H])\[C@]2([H])C[C@]2(N=C(O)[C@]2([H])C[C@]([H])(C[C@@]2([H])C(=O)N(C)CCCC1)OC1=C2C=CC(OC)=C(C)C2=NC(=C1)C1=NC(=CS1)C(C)C)C(O)=NS(=O)(=O)C1CC1
Pharmacology
IndicationSimeprevir is indicated in patient's with hepatitis C virus (HCV) genotype 1 for the treatment of chronic hepatitis as a combination therapy, which includes peginterferon alfa and ribavirin.
Structured Indications
PharmacodynamicsSimeprevir is a protease inhibitor for HCV NS3/4A protease, which is required for replication of the virus.
Mechanism of actionSimeprevir functions as a direct-acting antiviral agent because it inhibits hepatitis C viral replication by binding to and inhibiting the protease, hepatitis C virus (HCV) NS3/4A.
TargetKindPharmacological actionActionsOrganismUniProt ID
NS3 proteaseProteinyes
inhibitor
Hepatitis C virusQ91RS4 details
Related Articles
AbsorptionAfter oral administration, simeprevir reaches its maximum plasma concentrations in 4-6 hours.
Volume of distribution

The volume of distribution for simeprevir has yet to be determined.

Protein bindingSimeprevir is >99.9% plasma protein bound with albumin being the main plasma protein.
Metabolism

Simeprevir is mainly metabolized by CYP3A enzymes.

Route of eliminationSimeprevir is mainly eliminated through biliary excretion (91%). Elimination through the urine is insignificant (1%).
Half lifeThe half-life of simeprevir is about 41 hours in HCV patients.
Clearance

The clearance of simeprevir has yet to be determined.

ToxicityIn patients receiving the combination therapy, the most common adverse reactions were nausea, pruritus, photosensitivity, and rash.
Affected organisms
  • Hepatitis C virus, RSV and other RNA/DNA viruses
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe serum concentration of Simeprevir can be increased when it is combined with 1,10-Phenanthroline.Experimental
3,4-DichloroisocoumarinThe serum concentration of Simeprevir can be increased when it is combined with 3,4-Dichloroisocoumarin.Experimental
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Simeprevir can be increased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.Experimental
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Simeprevir.Approved, Investigational
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Simeprevir.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Simeprevir.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Simeprevir.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Simeprevir.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Simeprevir.Approved, Vet Approved
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Simeprevir.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Simeprevir.Approved
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Simeprevir.Approved, Investigational
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Simeprevir.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Simeprevir.Approved
AldosteroneThe serum concentration of Simeprevir can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Simeprevir can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Simeprevir.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Simeprevir.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Simeprevir.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Simeprevir.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Simeprevir.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Simeprevir.Approved, Investigational
AlogliptinThe serum concentration of Simeprevir can be increased when it is combined with Alogliptin.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Simeprevir.Approved, Withdrawn
Alpha-1-proteinase inhibitorThe serum concentration of Simeprevir can be increased when it is combined with Alpha-1-proteinase inhibitor.Approved
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational
AmantadineThe serum concentration of Simeprevir can be increased when it is combined with Amantadine.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Simeprevir.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Simeprevir.Approved
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Simeprevir.Experimental
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Simeprevir.Illicit, Withdrawn
Aminohippuric acidThe serum concentration of Simeprevir can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Simeprevir.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Simeprevir.Approved
AmiodaroneThe serum concentration of Simeprevir can be increased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Simeprevir.Approved
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Simeprevir.Approved
AmprenavirThe serum concentration of Simeprevir can be increased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Simeprevir can be increased when it is combined with Amsacrine.Approved
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Simeprevir.Approved
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Simeprevir.Approved
Antithrombin III humanThe serum concentration of Simeprevir can be increased when it is combined with Antithrombin III human.Approved
ApixabanThe serum concentration of Simeprevir can be increased when it is combined with Apixaban.Approved
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Simeprevir.Approved, Investigational
AprepitantThe serum concentration of Simeprevir can be increased when it is combined with Aprepitant.Approved, Investigational
AprotininThe serum concentration of Simeprevir can be increased when it is combined with Aprotinin.Approved, Withdrawn
ArgatrobanThe serum concentration of Simeprevir can be increased when it is combined with Argatroban.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Simeprevir.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Simeprevir.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Simeprevir.Approved
ASA404The metabolism of ASA404 can be decreased when combined with Simeprevir.Investigational
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Simeprevir.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Simeprevir.Approved, Withdrawn
AsunaprevirThe serum concentration of Simeprevir can be increased when it is combined with Asunaprevir.Approved, Investigational
AtazanavirThe serum concentration of Simeprevir can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Simeprevir can be increased when it is combined with Atenolol.Approved
AtomoxetineThe serum concentration of Simeprevir can be increased when it is combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Simeprevir.Approved
AV650The metabolism of AV650 can be decreased when combined with Simeprevir.Approved, Investigational
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Simeprevir.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Simeprevir.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Simeprevir.Approved
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Simeprevir.Approved
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Simeprevir.Investigational
BatimastatThe serum concentration of Simeprevir can be increased when it is combined with Batimastat.Experimental
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Simeprevir.Approved
BenazeprilThe serum concentration of Simeprevir can be increased when it is combined with Benazepril.Approved, Investigational
BendamustineThe metabolism of Bendamustine can be decreased when combined with Simeprevir.Approved, Investigational
BenzamidineThe serum concentration of Simeprevir can be increased when it is combined with Benzamidine.Experimental
BenzocaineThe serum concentration of Simeprevir can be increased when it is combined with Benzocaine.Approved
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Simeprevir.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Simeprevir.Approved
BepridilThe serum concentration of Simeprevir can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Simeprevir.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Simeprevir.Approved
BexaroteneThe serum concentration of Simeprevir can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Simeprevir.Approved
Bi201335The serum concentration of Simeprevir can be increased when it is combined with Bi201335.Investigational
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Simeprevir.Approved
BiperidenThe serum concentration of Simeprevir can be increased when it is combined with Biperiden.Approved
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Simeprevir.Approved
BivalirudinThe serum concentration of Simeprevir can be increased when it is combined with Bivalirudin.Approved, Investigational
BoceprevirThe serum concentration of Simeprevir can be increased when it is combined with Boceprevir.Approved
BortezomibThe serum concentration of Simeprevir can be increased when it is combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Simeprevir can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Simeprevir.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Simeprevir.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Simeprevir.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Simeprevir.Approved
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Simeprevir.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Simeprevir.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Simeprevir.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Simeprevir.Approved
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Simeprevir.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Simeprevir.Approved
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Simeprevir.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Simeprevir.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Simeprevir.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Simeprevir.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Simeprevir.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Simeprevir.Approved
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Simeprevir.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Simeprevir.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Simeprevir.Approved
CandesartanThe serum concentration of Simeprevir can be increased when it is combined with Candesartan.Approved
CandoxatrilThe serum concentration of Simeprevir can be increased when it is combined with Candoxatril.Experimental
CandoxatrilatThe serum concentration of Simeprevir can be increased when it is combined with Candoxatrilat.Experimental
CaptoprilThe serum concentration of Simeprevir can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Simeprevir can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Simeprevir.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Simeprevir.Approved
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Simeprevir.Approved
CarmustineThe metabolism of Carmustine can be decreased when combined with Simeprevir.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Simeprevir.Approved, Investigational
CaspofunginThe serum concentration of Simeprevir can be increased when it is combined with Caspofungin.Approved
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Simeprevir.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Simeprevir.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Simeprevir.Approved, Vet Approved
CeritinibThe serum concentration of Simeprevir can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Simeprevir.Withdrawn
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Simeprevir.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Simeprevir.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Simeprevir.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Simeprevir.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Simeprevir.Withdrawn
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Simeprevir.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Simeprevir.Approved, Vet Approved
ChlorpropamideThe serum concentration of Simeprevir can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Simeprevir can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Simeprevir.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Simeprevir.Approved, Nutraceutical
CholesterolThe serum concentration of Simeprevir can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Simeprevir can be decreased when it is combined with Cholic Acid.Approved
ChymostatinThe serum concentration of Simeprevir can be increased when it is combined with Chymostatin.Experimental
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Simeprevir.Approved, Investigational
CilastatinThe serum concentration of Simeprevir can be increased when it is combined with Cilastatin.Approved
CilazaprilThe serum concentration of Simeprevir can be increased when it is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Simeprevir.Approved
CimetidineThe serum concentration of Simeprevir can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Simeprevir.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Simeprevir.Approved
CiprofloxacinThe serum concentration of Simeprevir can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Simeprevir.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Simeprevir.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Simeprevir.Approved
ClarithromycinThe serum concentration of Simeprevir can be increased when it is combined with Clarithromycin.Approved
ClemastineThe serum concentration of Simeprevir can be increased when it is combined with Clemastine.Approved
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Simeprevir.Approved, Vet Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Simeprevir.Approved
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Simeprevir.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Simeprevir.Approved, Illicit
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Simeprevir.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Simeprevir.Approved
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Simeprevir.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Simeprevir.Approved, Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Simeprevir.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Simeprevir.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Simeprevir.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Simeprevir.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Simeprevir.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Simeprevir.Approved, Illicit
ClotrimazoleThe serum concentration of Simeprevir can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Simeprevir.Approved
CobicistatThe serum concentration of Simeprevir can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Simeprevir.Approved
CocaineThe serum concentration of Cocaine can be increased when it is combined with Simeprevir.Approved, Illicit
CodeineThe serum concentration of Codeine can be increased when it is combined with Simeprevir.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Simeprevir.Approved
ColforsinThe serum concentration of Simeprevir can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Simeprevir can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Simeprevir.Approved
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Simeprevir.Approved
CrizotinibThe serum concentration of Simeprevir can be increased when it is combined with Crizotinib.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Simeprevir.Approved
CyclophosphamideThe risk or severity of adverse effects can be increased when Simeprevir is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Simeprevir.Approved, Investigational
Dabigatran etexilateThe serum concentration of Simeprevir can be increased when it is combined with Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Simeprevir can be decreased when it is combined with Dabrafenib.Approved
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Simeprevir.Approved, Investigational
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Simeprevir.Approved
DactinomycinThe serum concentration of Simeprevir can be increased when it is combined with Dactinomycin.Approved
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Simeprevir.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Simeprevir.Approved
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Simeprevir.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Simeprevir.Approved, Investigational
DarunavirThe serum concentration of Simeprevir can be increased when it is combined with Darunavir.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Simeprevir.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Simeprevir.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Simeprevir.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Simeprevir.Approved
DeferasiroxThe serum concentration of Simeprevir can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe serum concentration of Simeprevir can be increased when it is combined with Delavirdine.Approved
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Simeprevir.Approved
DesloratadineThe serum concentration of Simeprevir can be increased when it is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Simeprevir.Approved
DexamethasoneThe serum concentration of Simeprevir can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Simeprevir.Approved, Illicit, Withdrawn
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Simeprevir.Approved
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Simeprevir.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Simeprevir.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Simeprevir.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Simeprevir.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Simeprevir.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Simeprevir.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Simeprevir.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Simeprevir.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Simeprevir.Approved, Illicit
DihydroergotamineThe serum concentration of Simeprevir can be increased when it is combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Simeprevir.Illicit
DiltiazemThe serum concentration of Simeprevir can be increased when it is combined with Diltiazem.Approved
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Simeprevir.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Simeprevir.Approved
DipyridamoleThe serum concentration of Simeprevir can be increased when it is combined with Dipyridamole.Approved
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Simeprevir.Approved
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Simeprevir.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Simeprevir.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Simeprevir.Approved
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Simeprevir.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Simeprevir.Approved
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Simeprevir.Approved
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Simeprevir.Approved
DoxazosinThe serum concentration of Simeprevir can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Simeprevir.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Simeprevir.Approved, Investigational
DoxycyclineThe serum concentration of Simeprevir can be increased when it is combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Simeprevir.Approved, Illicit
DronedaroneThe serum concentration of Simeprevir can be increased when it is combined with Dronedarone.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Simeprevir.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Simeprevir.Approved, Investigational
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Simeprevir.Approved
EcabetThe serum concentration of Simeprevir can be increased when it is combined with Ecabet.Approved, Investigational
EdoxabanThe serum concentration of Simeprevir can be increased when it is combined with Edoxaban.Approved
EfavirenzThe serum concentration of Simeprevir can be decreased when it is combined with Efavirenz.Approved, Investigational
ElafinThe serum concentration of Simeprevir can be increased when it is combined with Elafin.Investigational
ElbasvirThe serum concentration of Simeprevir can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Simeprevir.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Simeprevir.Approved
EltrombopagThe serum concentration of Simeprevir can be increased when it is combined with Eltrombopag.Approved
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Simeprevir.Approved
EnalaprilThe serum concentration of Simeprevir can be increased when it is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe serum concentration of Simeprevir can be increased when it is combined with Enalaprilat.Approved
EnalkirenThe serum concentration of Simeprevir can be increased when it is combined with Enalkiren.Experimental
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Simeprevir.Approved, Investigational
EnzalutamideThe serum concentration of Simeprevir can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Simeprevir.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Simeprevir.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Simeprevir.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Simeprevir.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Simeprevir.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Simeprevir.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Simeprevir.Approved, Investigational
ErythromycinThe serum concentration of Simeprevir can be increased when it is combined with Erythromycin.Approved, Vet Approved
EscitalopramThe serum concentration of Simeprevir can be decreased when it is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Simeprevir can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Simeprevir.Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Simeprevir.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Simeprevir.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Simeprevir.Approved
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Simeprevir.Approved
EstriolThe serum concentration of Simeprevir can be decreased when it is combined with Estriol.Approved, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Simeprevir.Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Simeprevir.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Simeprevir.Approved
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Simeprevir.Approved
EthanolThe serum concentration of Ethanol can be increased when it is combined with Simeprevir.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Simeprevir.Approved
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Simeprevir.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Simeprevir.Approved, Illicit
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Simeprevir.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Simeprevir.Approved
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Simeprevir.Approved, Investigational
EtravirineThe serum concentration of Simeprevir can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Simeprevir.Approved
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Simeprevir.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Simeprevir.Approved
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Simeprevir.Approved
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Simeprevir.Approved
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Simeprevir.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Simeprevir.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Simeprevir.Approved
FexofenadineThe serum concentration of Simeprevir can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Simeprevir can be increased when it is combined with Fidaxomicin.Approved
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Simeprevir.Approved
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Simeprevir.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Simeprevir.Approved
FluconazoleThe serum concentration of Simeprevir can be increased when it is combined with Fluconazole.Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Simeprevir.Approved
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Simeprevir.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Simeprevir.Approved, Illicit
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Simeprevir.Approved
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Simeprevir.Approved
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Simeprevir.Approved, Vet Approved
FlupentixolThe serum concentration of Simeprevir can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Simeprevir can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Simeprevir.Approved, Illicit
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Simeprevir.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Simeprevir.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Simeprevir.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Simeprevir.Approved
FluvoxamineThe serum concentration of Simeprevir can be increased when it is combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe serum concentration of Simeprevir can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Simeprevir can be increased when it is combined with Fosaprepitant.Approved
FosinoprilThe serum concentration of Simeprevir can be increased when it is combined with Fosinopril.Approved
FosphenytoinThe serum concentration of Simeprevir can be decreased when it is combined with Fosphenytoin.Approved
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Simeprevir.Approved, Investigational
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Simeprevir.Approved, Investigational
Fusidic AcidThe serum concentration of Simeprevir can be increased when it is combined with Fusidic Acid.Approved
GabexateThe serum concentration of Simeprevir can be increased when it is combined with Gabexate.Investigational
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Simeprevir.Approved
GarlicThe serum concentration of Simeprevir can be decreased when it is combined with Garlic.Approved
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Simeprevir.Approved, Investigational
GeldanamycinThe serum concentration of Simeprevir can be increased when it is combined with Geldanamycin.Experimental
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Simeprevir.Approved
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Simeprevir.Approved
GenisteinThe serum concentration of Simeprevir can be increased when it is combined with Genistein.Investigational
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Simeprevir.Approved
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Simeprevir.Approved
GlycerolThe serum concentration of Simeprevir can be increased when it is combined with Glycerol.Experimental
GM6001The serum concentration of Simeprevir can be increased when it is combined with GM6001.Experimental
Gramicidin DThe serum concentration of Simeprevir can be increased when it is combined with Gramicidin D.Approved
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Simeprevir.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Simeprevir.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Simeprevir.Withdrawn
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Simeprevir.Approved
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Simeprevir.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Simeprevir.Approved
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Simeprevir.Approved
HalothaneThe serum concentration of Halothane can be increased when it is combined with Simeprevir.Approved, Vet Approved
HesperetinThe metabolism of Hesperetin can be decreased when combined with Simeprevir.Approved
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Simeprevir.Withdrawn
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Simeprevir.Approved
HirulogThe serum concentration of Simeprevir can be increased when it is combined with Hirulog.Experimental
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Simeprevir.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Simeprevir.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Simeprevir.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Simeprevir.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Simeprevir.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Simeprevir.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Simeprevir.Approved
IdelalisibThe serum concentration of Simeprevir can be increased when it is combined with Idelalisib.Approved
idraparinuxThe serum concentration of Simeprevir can be increased when it is combined with idraparinux.Investigational
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Simeprevir.Approved
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Simeprevir.Approved
ImatinibThe serum concentration of Simeprevir can be increased when it is combined with Imatinib.Approved
ImidaprilThe serum concentration of Simeprevir can be increased when it is combined with Imidapril.Investigational
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Simeprevir.Approved
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Simeprevir.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Simeprevir.Approved
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Simeprevir.Approved
IndinavirThe serum concentration of Simeprevir can be increased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Simeprevir can be increased when it is combined with Indomethacin.Approved, Investigational
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Simeprevir.Approved
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Simeprevir.Approved, Investigational
IsavuconazoniumThe serum concentration of Simeprevir can be increased when it is combined with Isavuconazonium.Approved, Investigational
IsoflurophateThe serum concentration of Simeprevir can be increased when it is combined with Isoflurophate.Approved, Withdrawn
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Simeprevir.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Simeprevir.Approved
IsradipineThe serum concentration of Simeprevir can be increased when it is combined with Isradipine.Approved
ItraconazoleThe serum concentration of Simeprevir can be increased when it is combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Simeprevir.Approved
IvacaftorThe serum concentration of Simeprevir can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Simeprevir.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Simeprevir.Approved, Investigational
IxazomibThe serum concentration of Simeprevir can be increased when it is combined with Ixazomib.Approved
KetamineThe serum concentration of Ketamine can be increased when it is combined with Simeprevir.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Simeprevir.Approved
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Simeprevir.Approved
KetoconazoleThe serum concentration of Simeprevir can be increased when it is combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Simeprevir.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Simeprevir.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Simeprevir.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Simeprevir.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Simeprevir.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Simeprevir.Approved
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Simeprevir.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Simeprevir.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Simeprevir.Approved
LepirudinThe serum concentration of Simeprevir can be increased when it is combined with Lepirudin.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Simeprevir.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Simeprevir.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Simeprevir.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Simeprevir.Approved
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Simeprevir.Approved
LevofloxacinThe serum concentration of Simeprevir can be increased when it is combined with Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Simeprevir.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Simeprevir.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Simeprevir.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Simeprevir.Approved
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Simeprevir.Approved, Vet Approved
LinagliptinThe serum concentration of Simeprevir can be increased when it is combined with Linagliptin.Approved
LiothyronineThe serum concentration of Simeprevir can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Simeprevir can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Simeprevir can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe serum concentration of Lisuride can be increased when it is combined with Simeprevir.Approved
LomefloxacinThe metabolism of Lomefloxacin can be decreased when combined with Simeprevir.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Simeprevir.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Simeprevir.Approved
LopinavirThe serum concentration of Simeprevir can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Simeprevir.Approved
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Simeprevir.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Simeprevir.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Simeprevir.Approved, Investigational
LuliconazoleThe serum concentration of Simeprevir can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Simeprevir can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Simeprevir.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Simeprevir.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Simeprevir.Approved
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Simeprevir.Approved
MalathionThe metabolism of Malathion can be decreased when combined with Simeprevir.Approved, Investigational
MannitolThe serum concentration of Mannitol can be increased when it is combined with Simeprevir.Approved, Investigational
MaprotilineThe serum concentration of Simeprevir can be increased when it is combined with Maprotiline.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Simeprevir.Approved, Investigational
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Simeprevir.Approved, Vet Approved
MecamylamineThe risk or severity of adverse effects can be increased when Simeprevir is combined with Mecamylamine.Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Simeprevir.Approved, Investigational
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Simeprevir.Approved
Megestrol acetateThe serum concentration of Simeprevir can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Simeprevir.Approved, Nutraceutical, Vet Approved
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Simeprevir.Approved, Vet Approved
MenadioneThe metabolism of Menadione can be decreased when combined with Simeprevir.Approved, Nutraceutical
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Simeprevir.Investigational, Withdrawn
MeprobamateThe serum concentration of Simeprevir can be increased when it is combined with Meprobamate.Approved, Illicit
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Simeprevir.Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Simeprevir.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Simeprevir.Experimental
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Simeprevir.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Simeprevir.Approved
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Simeprevir.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Simeprevir.Approved, Vet Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Simeprevir.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Simeprevir.Approved
MetoprololThe serum concentration of Simeprevir can be increased when it is combined with Metoprolol.Approved, Investigational
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Simeprevir.Approved
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Simeprevir.Approved
MianserinThe serum concentration of Mianserin can be increased when it is combined with Simeprevir.Approved
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Simeprevir.Withdrawn
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Simeprevir.Approved, Illicit
MifepristoneThe serum concentration of Simeprevir can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Simeprevir.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Simeprevir.Approved
MitomycinThe serum concentration of Simeprevir can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Simeprevir can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Simeprevir can be decreased when it is combined with Mitoxantrone.Approved, Investigational
ModafinilThe serum concentration of Simeprevir can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilThe serum concentration of Simeprevir can be increased when it is combined with Moexipril.Approved
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Simeprevir.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Simeprevir.Approved, Investigational
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Simeprevir.Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Simeprevir.Approved, Investigational
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Simeprevir can be increased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.Experimental
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Simeprevir.Approved
NadololThe serum concentration of Nadolol can be increased when it is combined with Simeprevir.Approved
NafamostatThe serum concentration of Simeprevir can be increased when it is combined with Nafamostat.Investigational
NafcillinThe serum concentration of Simeprevir can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Simeprevir.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Simeprevir.Approved, Vet Approved
NaltrexoneThe serum concentration of Simeprevir can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Simeprevir.Approved, Vet Approved
NaringeninThe serum concentration of Simeprevir can be increased when it is combined with Naringenin.Experimental
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Simeprevir.Approved, Investigational
NCX 4016The serum concentration of Simeprevir can be increased when it is combined with NCX 4016.Investigational
NefazodoneThe serum concentration of Simeprevir can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Simeprevir can be increased when it is combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Simeprevir can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Simeprevir can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Simeprevir can be increased when it is combined with Nevirapine.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Simeprevir.Approved
NicotineThe serum concentration of Nicotine can be increased when it is combined with Simeprevir.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Simeprevir.Approved
NilotinibThe serum concentration of Simeprevir can be increased when it is combined with Nilotinib.Approved, Investigational
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Simeprevir.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Simeprevir.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Simeprevir.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Simeprevir.Approved
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Simeprevir.Approved
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Simeprevir.Approved
Nitric OxideThe metabolism of Nitric Oxide can be decreased when combined with Simeprevir.Approved
NitroaspirinThe serum concentration of Simeprevir can be increased when it is combined with Nitroaspirin.Investigational
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Simeprevir.Approved
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Simeprevir.Approved
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Simeprevir.Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Simeprevir.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Simeprevir.Approved, Investigational
OlaparibThe serum concentration of Simeprevir can be increased when it is combined with Olaparib.Approved
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Simeprevir.Approved
OmapatrilatThe serum concentration of Simeprevir can be increased when it is combined with Omapatrilat.Investigational
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Simeprevir.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Simeprevir.Approved
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Simeprevir.Investigational
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Simeprevir.Approved
OsimertinibThe serum concentration of Simeprevir can be increased when it is combined with Osimertinib.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Simeprevir.Approved
OtamixabanThe serum concentration of Simeprevir can be increased when it is combined with Otamixaban.Investigational
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Simeprevir.Approved, Investigational
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Simeprevir.Approved
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Simeprevir.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Simeprevir.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Simeprevir can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Simeprevir.Approved, Vet Approved
PalbociclibThe serum concentration of Simeprevir can be increased when it is combined with Palbociclib.Approved
Palmitic AcidThe serum concentration of Simeprevir can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Simeprevir.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Simeprevir.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Simeprevir.Approved
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Simeprevir.Approved
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Simeprevir.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Simeprevir.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Simeprevir.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Simeprevir.Approved
ParoxetineThe serum concentration of Simeprevir can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Simeprevir.Approved
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Simeprevir.Approved
PentobarbitalThe serum concentration of Simeprevir can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Simeprevir.Approved, Investigational
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Simeprevir.Approved
PergolideThe serum concentration of Pergolide can be increased when it is combined with Simeprevir.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Simeprevir.Approved
PerindoprilThe serum concentration of Simeprevir can be increased when it is combined with Perindopril.Approved
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Simeprevir.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Simeprevir.Approved
PethidineThe risk or severity of adverse effects can be increased when Simeprevir is combined with Pethidine.Approved
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Simeprevir.Withdrawn
PhenobarbitalThe serum concentration of Simeprevir can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Simeprevir.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Simeprevir.Approved
PhenytoinThe serum concentration of Simeprevir can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PhosphoramidonThe serum concentration of Simeprevir can be increased when it is combined with Phosphoramidon.Experimental
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Simeprevir.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Simeprevir.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Simeprevir.Approved
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Simeprevir.Withdrawn
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Simeprevir.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Simeprevir.Approved
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Simeprevir.Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Simeprevir.Approved
Platelet Activating FactorThe serum concentration of Simeprevir can be decreased when it is combined with Platelet Activating Factor.Experimental
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Simeprevir.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Simeprevir.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Simeprevir.Approved
PosaconazoleThe serum concentration of Simeprevir can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be increased when it is combined with Simeprevir.Approved, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Simeprevir.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Simeprevir.Approved
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Simeprevir.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Simeprevir.Approved, Vet Approved
PrazosinThe serum concentration of Simeprevir can be increased when it is combined with Prazosin.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Simeprevir.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Simeprevir.Approved, Vet Approved
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Simeprevir.Approved
PrimidoneThe serum concentration of Simeprevir can be decreased when it is combined with Primidone.Approved, Vet Approved
PrinomastatThe serum concentration of Simeprevir can be increased when it is combined with Prinomastat.Investigational
ProbenecidThe serum concentration of Simeprevir can be increased when it is combined with Probenecid.Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Simeprevir.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Simeprevir.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Simeprevir.Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Simeprevir.Approved, Vet Approved
PromethazineThe serum concentration of Simeprevir can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Simeprevir.Approved
PropofolThe serum concentration of Propofol can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Simeprevir.Approved, Investigational
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Simeprevir.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Simeprevir.Approved
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Simeprevir.Approved
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Simeprevir.Approved, Illicit
QuercetinThe serum concentration of Simeprevir can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Simeprevir.Approved
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Simeprevir.Approved
QuinaprilThe serum concentration of Simeprevir can be increased when it is combined with Quinapril.Approved, Investigational
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Simeprevir.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Simeprevir.Approved
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Simeprevir.Approved, Investigational
RacecadotrilThe serum concentration of Simeprevir can be increased when it is combined with Racecadotril.Investigational
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Simeprevir.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Simeprevir.Approved, Investigational
RamiprilThe serum concentration of Simeprevir can be increased when it is combined with Ramipril.Approved
RanitidineThe serum concentration of Simeprevir can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Simeprevir can be increased when it is combined with Ranolazine.Approved, Investigational
RasagilineThe metabolism of Rasagiline can be decreased when combined with Simeprevir.Approved
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Simeprevir.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Simeprevir.Approved
RemikirenThe serum concentration of Simeprevir can be increased when it is combined with Remikiren.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Simeprevir.Approved, Investigational
ReserpineThe serum concentration of Simeprevir can be decreased when it is combined with Reserpine.Approved
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Simeprevir.Experimental, Investigational
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Simeprevir.Approved
RifabutinThe serum concentration of Simeprevir can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Simeprevir can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Simeprevir can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Simeprevir.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Simeprevir.Approved
RiluzoleThe metabolism of Riluzole can be decreased when combined with Simeprevir.Approved, Investigational
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Simeprevir.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Simeprevir.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Simeprevir.Approved, Investigational
RitonavirThe serum concentration of Simeprevir can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Simeprevir can be increased when it is combined with Rivaroxaban.Approved
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Simeprevir.Approved
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Simeprevir.Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Simeprevir.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Simeprevir.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Simeprevir.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Simeprevir.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Simeprevir.Approved
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Simeprevir.Approved
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Simeprevir.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Simeprevir.Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Simeprevir.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Simeprevir.Approved
SaquinavirThe serum concentration of Simeprevir can be increased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Simeprevir can be increased when it is combined with Saxagliptin.Approved
ScopolamineThe serum concentration of Simeprevir can be increased when it is combined with Scopolamine.Approved
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Simeprevir.Approved
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Simeprevir.Approved, Investigational
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Simeprevir.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be increased when it is combined with Simeprevir.Approved
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Simeprevir.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Simeprevir can be increased when it is combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Simeprevir.Approved
SiltuximabThe serum concentration of Simeprevir can be decreased when it is combined with Siltuximab.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Simeprevir.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Simeprevir.Approved, Investigational
SitagliptinThe serum concentration of Simeprevir can be increased when it is combined with Sitagliptin.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Simeprevir.Approved
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Simeprevir.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Simeprevir.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Simeprevir.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Simeprevir.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Simeprevir.Experimental
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Simeprevir.Approved
SpiraprilThe serum concentration of Simeprevir can be increased when it is combined with Spirapril.Approved
SpironolactoneThe serum concentration of Simeprevir can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Simeprevir can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Simeprevir can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Simeprevir can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Simeprevir can be decreased when it is combined with Streptozocin.Approved
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Simeprevir.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Simeprevir.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Simeprevir.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Simeprevir.Approved
SulfisoxazoleThe serum concentration of Simeprevir can be increased when it is combined with Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Simeprevir can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Simeprevir.Approved, Investigational
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Simeprevir.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Simeprevir.Approved
TacrineThe serum concentration of Simeprevir can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Simeprevir.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Simeprevir.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Simeprevir.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Simeprevir.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Simeprevir.Approved, Investigational
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Simeprevir.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Simeprevir.Experimental
Taurocholic AcidThe serum concentration of Simeprevir can be increased when it is combined with Taurocholic Acid.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Simeprevir.Approved
TelaprevirThe serum concentration of Simeprevir can be increased when it is combined with Telaprevir.Approved
TelithromycinThe serum concentration of Simeprevir can be increased when it is combined with Telithromycin.Approved
TelmisartanThe serum concentration of Simeprevir can be increased when it is combined with Telmisartan.Approved, Investigational
TemafloxacinThe metabolism of Temafloxacin can be decreased when combined with Simeprevir.Withdrawn
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Simeprevir.Approved
TemocaprilThe serum concentration of Simeprevir can be increased when it is combined with Temocapril.Experimental, Investigational
TemsirolimusThe risk or severity of adverse effects can be increased when Simeprevir is combined with Temsirolimus.Approved
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Simeprevir.Approved
TenofovirThe serum concentration of Simeprevir can be decreased when it is combined with Tenofovir.Approved, Investigational
TerazosinThe serum concentration of Simeprevir can be increased when it is combined with Terazosin.Approved
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Simeprevir.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Simeprevir.Withdrawn
TeriflunomideThe serum concentration of Simeprevir can be increased when it is combined with Teriflunomide.Approved
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Simeprevir.Investigational
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Simeprevir.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Simeprevir.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Simeprevir.Approved, Investigational, Withdrawn
TheobromineThe metabolism of Theobromine can be decreased when combined with Simeprevir.Approved
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Simeprevir.Approved
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Simeprevir.Approved, Vet Approved
ThioridazineThe metabolism of Thioridazine can be decreased when combined with Simeprevir.Approved
ThiorphanThe serum concentration of Simeprevir can be increased when it is combined with Thiorphan.Experimental
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Simeprevir.Approved
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Simeprevir.Approved
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Simeprevir.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Simeprevir.Approved
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Simeprevir.Approved
TiclopidineThe serum concentration of Simeprevir can be increased when it is combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Simeprevir.Approved
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Simeprevir.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Simeprevir.Approved
TipranavirThe serum concentration of Simeprevir can be increased when it is combined with Tipranavir.Approved, Investigational
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Simeprevir.Approved
TocilizumabThe serum concentration of Simeprevir can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Simeprevir.Approved, Investigational
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Simeprevir.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Simeprevir.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Simeprevir.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Simeprevir.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Simeprevir.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Simeprevir.Approved, Investigational
TrandolaprilThe serum concentration of Simeprevir can be increased when it is combined with Trandolapril.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Simeprevir.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Simeprevir.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Simeprevir.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Simeprevir.Approved, Vet Approved
TriamtereneThe metabolism of Triamterene can be decreased when combined with Simeprevir.Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Simeprevir.Approved
TrifluoperazineThe serum concentration of Simeprevir can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Simeprevir can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Simeprevir.Approved
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Simeprevir.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Simeprevir.Approved
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Simeprevir.Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Simeprevir.Approved
UbenimexThe serum concentration of Simeprevir can be increased when it is combined with Ubenimex.Experimental
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Simeprevir.Approved, Investigational
UlinastatinThe serum concentration of Simeprevir can be increased when it is combined with Ulinastatin.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Simeprevir.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Simeprevir.Approved
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Simeprevir.Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Simeprevir.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Simeprevir.Approved
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Simeprevir.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Simeprevir.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Simeprevir.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Simeprevir.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Simeprevir.Approved
VenlafaxineThe serum concentration of Simeprevir can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Simeprevir can be increased when it is combined with Verapamil.Approved
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Simeprevir.Investigational
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Simeprevir.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Simeprevir.Approved
VildagliptinThe serum concentration of Simeprevir can be increased when it is combined with Vildagliptin.Approved, Investigational
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Simeprevir.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Simeprevir.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Simeprevir.Approved
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Simeprevir.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Simeprevir.Approved
VoriconazoleThe serum concentration of Simeprevir can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Simeprevir.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Simeprevir.Approved
XimelagatranThe serum concentration of Simeprevir can be increased when it is combined with Ximelagatran.Approved, Investigational, Withdrawn
Ym150The serum concentration of Simeprevir can be increased when it is combined with Ym150.Investigational
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Simeprevir.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Simeprevir.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Simeprevir.Approved
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Simeprevir.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Simeprevir.Approved
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Simeprevir.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Simeprevir can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe serum concentration of Simeprevir can be increased when it is combined with Ziprasidone.Approved
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Simeprevir.Approved, Investigational
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Simeprevir.Approved
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Simeprevir.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Simeprevir.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Simeprevir.Approved
Food Interactions
  • Simeprevir should be taken with food.
References
Synthesis Reference

Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wahling H, Wickstrom K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K: Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24.

General References
  1. Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wahling H, Wickstrom K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K: Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24. [PubMed:18678486 ]
External Links
ATC CodesJ05AE14
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (85.3 KB)
ADMET
Predicted ADMET featuresNot Available
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
CapsuleOral150 mg
CapsuleOral150 mg/1
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7671032 No2005-05-192025-05-19Us
US8148399 No2009-09-052029-09-05Us
US8349869 No2006-07-282026-07-28Us
US8741926 No2006-07-282026-07-28Us
US8754106 No2006-07-282026-07-28Us
US9040562 No2006-07-282026-07-28Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.00458 mg/mLALOGPS
logP4.82ALOGPS
logP5.74ChemAxon
logS-5.2ALOGPS
pKa (Strongest Acidic)5.87ChemAxon
pKa (Strongest Basic)1.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count11ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area163.87 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity207.79 m3·mol-1ChemAxon
Polarizability80.18 Å3ChemAxon
Number of Rings7ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassMacrolactams
Sub ClassNot Available
Direct ParentMacrolactams
Alternative Parents
Substituents
  • Macrolactam
  • Alpha-amino acid amide
  • Quinoline
  • Anisole
  • Alkyl aryl ether
  • 2,4-disubstituted 1,3-thiazole
  • Benzenoid
  • Pyridine
  • Cyclopropanecarboxylic acid or derivatives
  • Heteroaromatic compound
  • Aminosulfonyl compound
  • Thiazole
  • Tertiary carboxylic acid amide
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Azole
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Lactam
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Hepatitis C virus
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine-type peptidase activity
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q91RS4
Molecular Weight:
19113.77 Da
References
  1. Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wahling H, Wickstrom K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K: Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24. [PubMed:18678486 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
binder
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
Comments
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Drug created on March 19, 2008 10:22 / Updated on December 10, 2016 02:41