Chronic Renal Failure (CRF)

Also known as: Renal Failure, Chronic / Chronic Renal Failure / Kidney Failure,Chronic / Kidney Failure Chronic / Chronic Kidney Failure / Renal Failure Chronic / Kidney Failure, Chronic / End Stage Renal Failure / Renal Failure , Chronic / Chronic kidney disease / Chronic Kidney Diseases / Chronic renal disease / Chronic kidney disease (CKD) / End stage renal disease (ESRD)

DrugDrug NameDrug Description
DB01436AlfacalcidolAlfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. Alfacalcidol is Vitamin D-hormone analog which is activated by the enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone actions. It possesses a unique pattern of pleiotropic effects on, e.g. gut, bone, pararthyroids, muscle and brain. Alfacalcidol is superior to plain vitamin D (cholecalciferol) because the final kidney activation of the latter is regulated by a negative feedback mechanism. [A175348,A175351]
DB00136CalcitriolCalcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to [DB00169] (vitamin D3) in the skin, which is then converted to [DB00146] in the liver and kidneys. [DB00146] undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity [A26353]. Calcitriol is considered to be the most potent metabolite of vitamin D in humans [A3366]. Renal production of calcitriol is stimulated in response to PTH, low calcium and low phosphate [A26353]. Calcitriol plays a role in plasma calcium regulation in concert with parathyroid hormone (PTH) by enhancing absorption of dietary calcium and phosphate from the gastrointestinal tract, promoting renal tubular reabsorption of calcium in the kidneys, and stimulating the release of calcium stores from the skeletal system. In addition to promoting fatty acid synthesis and inhibiting lipolysis, calcitriol has been demonstrated to increase energy efficiency by suppressing UCP2 expression, which is modulated by signaling pathways of classical nuclear receptors (nVDR), where calcitriol acts as a natural ligand [A175615]. There is also evidence that calcitriol modulates the action of cytokines and may regulate immune and inflammatory response, cell turnover, cell differentiation [A26353]. Administered orally and intravenously, calcitriol is commonly used as a medication in the treatment of secondary hyperparathyroidism and resultant metabolic bone disease, hypocalcemia in patients undergoing chronic renal dialysis, and osteoporosis. It is also available in topical form for the treatment of mild to moderate plaque psoriasis in adults. Calcitriol is marketed under various trade names including Rocaltrol (Roche), Calcijex (Abbott) and Decostriol (Mibe, Jesalis).
DB00258Calcium acetateThe chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form.
DB00746DeferoxamineNatural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
DB11624Epoetin deltaEpoetin Delta is an ingredient in the EMA-withdrawn product Dynepo.
DB00232MethyclothiazideA thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
DrugDrug NamePhaseStatusCount
DB00028Immune Globulin Human0Completed1
DB14276Turmeric0Completed1
DB11704Adomeglivant1Completed1
DB12139Alisporivir1Completed1
DB06681Belatacept1Active Not Recruiting1
DB00146Calcifediol1Completed1
DB06695Dabigatran etexilate1Completed1
DB06410Doxercalciferol1Completed1
DB15077Efinopegdutide1Completed1
DB00016Erythropoietin1Completed2
DB00028Immune Globulin Human1Completed1
DB01592Iron1Completed1
DB09146Iron saccharate1Completed1
DB06792Lanthanum carbonate1Completed1
DB08935Obinutuzumab1Completed1
DB08894Peginesatide1Completed1
DB14974Pimodivir1Not Yet Recruiting1
DB00073Rituximab1Active Not Recruiting1
DB05794Serelaxin1Completed1
DB00658Sevelamer1Completed1
DB00877Sirolimus1Completed1
DB09517Sodium ferric gluconate complex1Completed1
DB08816Ticagrelor1Completed1
DB00684Tobramycin1Recruiting1
DB12000Apabetalone1 / 2Not Yet Recruiting1
DB12849Clazakizumab1 / 2Recruiting1
DB06556Edifoligide1 / 2Terminated1
DB00095Efalizumab1 / 2Terminated1
DB14276Turmeric1 / 2Completed1
DB06151Acetylcysteine2Completed1
DB00087Alemtuzumab2Completed1
DB05024CTA0182Completed1
DB00531Cyclophosphamide2Completed1
DB00586Diclofenac2Terminated1
DB00016Erythropoietin2Completed2
DB00016Erythropoietin2Recruiting1
DB00800Fenoldopam2Completed1
DB01611Hydroxychloroquine2Terminated1
DB00028Immune Globulin Human2Terminated1
DB06655Liraglutide2Withdrawn1
DB01283Lumiracoxib2Terminated1
DB00959Methylprednisolone2Completed1
DB00688Mycophenolate mofetil2Completed3
DB08894Peginesatide2Completed5
DB08894Peginesatide2Terminated3
DB00635Prednisone2Completed1
DB00073Rituximab2Completed2
DB00360Sapropterin2Completed1
DB00658Sevelamer2Completed3
DB06371Siplizumab2Completed1
DB00877Sirolimus2Completed1
DB05995Sotatercept2Completed1
DB12118Sotatercept2Completed1
DB14101Soy isoflavones2Completed1
DB11657Tabalumab2Completed1
DB00864Tacrolimus2Completed2
DB06212Tolvaptan2Completed3
DB06151Acetylcysteine2 / 3Unknown Status1
DB00126Ascorbic acid2 / 3Completed1
DB00125L-Arginine2 / 3Unknown Status1
DB00163Vitamin E2 / 3Completed1
DB06151Acetylcysteine3Completed1
DB00098Antithymocyte immunoglobulin (rabbit)3Completed1
DB00407Ardeparin3Recruiting1
DB00091Ciclosporin3Completed1
DB01012Cinacalcet3Completed1
DB01012Cinacalcet3Terminated1
DB00758Clopidogrel3Completed1
DB09102Daclatasvir3Recruiting1
DB00111Daclizumab3Completed1
DB06779Dalteparin3Completed1
DB00012Darbepoetin alfa3Completed3
DB01234Dexamethasone3Completed1
DB00633Dexmedetomidine3Completed1
DB00016Erythropoietin3Completed5
DB00016Erythropoietin3Terminated1
DB01590Everolimus3Terminated1
DB01109Heparin3Recruiting1
DB01109Heparin3Unknown Status1
DB13886Human cytomegalovirus immune globulin3Completed1
DB01029Irbesartan3Completed1
DB06792Lanthanum carbonate3Completed4
DB06792Lanthanum carbonate3Terminated1
DB00683Midazolam3Completed1
DB00688Mycophenolate mofetil3Completed1
DB00627Niacin3Terminated1
DB02701Nicotinamide3Terminated1
DB08894Peginesatide3Completed4
DB00806Pentoxifylline3Completed1
DB06209Prasugrel3Completed1
DB00635Prednisone3Completed1
DB00178Ramipril3Completed1
DB00658Sevelamer3Completed2
DB00658Sevelamer3Terminated2
DB11080Silver nitrate3Completed1
DB00877Sirolimus3Recruiting1
DB09153Sodium chloride3Completed1
DB08934Sofosbuvir3Recruiting1
DB00052Somatotropin3Completed1
DB00864Tacrolimus3Completed1
DB00966Telmisartan3Completed1
DB00624Testosterone3Recruiting1
DB06361rsPSMA Vaccine3Completed1
DB06151Acetylcysteine4Unknown Status1
DB00173Adenine4Unknown Status1
DB09026Aliskiren4Terminated1
DB00770Alprostadil4Unknown Status1
DB00381Amlodipine4Completed1
DB00278Argatroban4Completed1
DB00074Basiliximab4Completed1
DB00146Calcifediol4Unknown Status1
DB01373Calcium4Completed2
DB00796Candesartan cilexetil4Unknown Status1
DB06774Capsaicin4Unknown Status1
DB00091Ciclosporin4Completed2
DB00091Ciclosporin4Unknown Status1
DB01012Cinacalcet4Completed1
DB00257Clotrimazole4Completed1
DB09102Daclatasvir4Completed1
DB00111Daclizumab4Unknown Status1
DB00012Darbepoetin alfa4Completed1
DB06410Doxercalciferol4Completed1
DB11574Elbasvir4Withdrawn1
DB00584Enalapril4Unknown Status1
DB00700Eplerenone4Completed1
DB11624Epoetin delta4Terminated1
DB00153Ergocalciferol4Not Yet Recruiting1
DB00016Erythropoietin4Completed3
DB01590Everolimus4Completed1
DB01590Everolimus4Recruiting1
DB13949Ferric cation4Completed1
DB00158Folic acid4Completed1
DB13879Glecaprevir4Recruiting1
DB11575Grazoprevir4Withdrawn1
DB01109Heparin4Completed1
DB01050Ibuprofen4Recruiting1
DB14455Influenza a virus a/california/7/2009 x-181 (h1n1) antigen (formaldehyde inactivated)4Completed1
DB01306Insulin Aspart4Completed1
DB01249Iodixanol4Completed1
DB01249Iodixanol4Unknown Status1
DB09156Iopromide4Completed1
DB09156Iopromide4Unknown Status1
DB01592Iron4Completed2
DB09146Iron saccharate4Completed2
DB06790Iron saccharate4Unknown Status1
DB09146Iron saccharate4Unknown Status1
DB12938Isoxaflutole4Completed2
DB06792Lanthanum carbonate4Completed1
DB08882Linagliptin4Completed1
DB00688Mycophenolate mofetil4Completed1
DB01024Mycophenolic acid4Completed1
DB01024Mycophenolic acid4Recruiting1
DB01115Nifedipine4Completed1
DB00646Nystatin4Completed1
DB00910Paricalcitol4Completed1
DB09263Patiromer4Completed1
DB00082Pegvisomant4Completed1
DB00806Pentoxifylline4Recruiting1
DB13878Pibrentasvir4Recruiting1
DB00635Prednisone4Completed1
DB00635Prednisone4Recruiting1
DB06228Rivaroxaban4Completed1
DB00877Sirolimus4Completed1
DB00877Sirolimus4Unknown Status1
DB09517Sodium ferric gluconate complex4Completed2
DB08934Sofosbuvir4Completed1
DB00052Somatotropin4Completed1
DB00421Spironolactone4Completed1
DB00421Spironolactone4Unknown Status1
DB06206Sugammadex4Completed1
DB00864Tacrolimus4Completed3
DB00864Tacrolimus4Recruiting1
DB06822Tinzaparin4Completed1
DB01344Tolevamer4Completed1
DB09270Ubidecarenone4Completed1
DB11094Vitamin D4Not Yet Recruiting1
DB06151AcetylcysteineNot AvailableTerminated1
DB00630Alendronic acidNot AvailableRecruiting1
DB00126Ascorbic acidNot AvailableUnknown Status1
DB00993AzathioprineNot AvailableCompleted1
DB00542BenazeprilNot AvailableTerminated1
DB06724Calcium CarbonateNot AvailableWithdrawn1
DB00091CiclosporinNot AvailableCompleted1
DB01012CinacalcetNot AvailableRecruiting1
DB00012Darbepoetin alfaNot AvailableCompleted2
DB11624Epoetin deltaNot AvailableTerminated1
DB00016ErythropoietinNot AvailableCompleted1
DB00016ErythropoietinNot AvailableUnknown Status1
DB05059ILY101Not AvailableActive Not Recruiting1
DB06792Lanthanum carbonateNot AvailableCompleted1
DB00281LidocaineNot AvailableCompleted1
DB00959MethylprednisoloneNot AvailableRecruiting2
DB00688Mycophenolate mofetilNot AvailableCompleted1
DB00688Mycophenolate mofetilNot AvailableTerminated1
DB00082PegvisomantNot AvailableCompleted1
DB00296RopivacaineNot AvailableCompleted1
DB00658SevelamerNot AvailableWithdrawn1
DB00641SimvastatinNot AvailableCompleted1
DB00864TacrolimusNot AvailableCompleted1
DB00706TamsulosinNot AvailableUnknown Status1
DB06285TeriparatideNot AvailableRecruiting1
DB00495ZidovudineNot AvailableCompleted1
DB01593ZincNot AvailableCompleted1
DB01593ZincNot AvailableTerminated1