Also known as: Hyperphosphatemia

DrugDrug NameDrug Description
DB06723Aluminum hydroxideAluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
DB00258Calcium AcetateThe chemical compound calcium acetate is the calcium salt of acetic acid. An older name is acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. [Wikipedia]
DB06724Calcium CarbonateCalcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.
DB13949Ferric cationIron is a transition metal with a symbol Fe and atomic number 26. By mass, it is the most common element on Earth. Iron is an essential element involved in various metabolic processes, including oxygen transport, deoxyribonucleic acid (DNA) synthesis, and energy production in electron transport [A32514]. Resulting from inadequate supply of iron to cells due to depletion of stores, iron deficiency is the most common nutritional deficiency worldwide, particularly affecting children, women of childbearing age, and pregnant women [L2257]. Iron deficiency may be characterized without the development of anemia, and may result in functional impairments affecting cognitive development and immunity mechanisms, as well as infant or maternal mortality if it occurs during pregnancy [A32514]. The main therapeutic preparation of iron is [DB13257], and iron-sucrose may also be given intravenously [T28]. Iron exists in two oxidation states: the ferrous cation (Fe2+) and ferric cation (Fe3+). Non-haem iron in food is mainly in the ferric state, which is the insoluble form of iron, and must be reduced to the ferrous cation for absorption [T28]. Ferric citrate (tetraferric tricitrate decahydrate) is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.
DB09146Iron saccharateIron saccharate (Sucroferric oxyhydroxide or Iron Sucrose) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, iron saccharate is more preferred in chronic kidney disease patients.
DB06792Lanthanum carbonateLanthanum carbonate is used in medicine as a phosphate binder. As a medication it is sold under the trade name Fosrenol by the pharmaceutical company Shire Pharmaceuticals. Fosrenol is the largest of all pills filled in community pharmacies. Sometimes patients forget that fosrenol is not swallowed whole, but instead should be chewed. This has led to severe choking. It is prescribed for the treatment of hyperphosphatemia, primarily in patients with chronic kidney disease. It is taken with meals and binds to dietary phosphate, preventing phosphate from being absorbed by the intestine.
DB00658SevelamerSevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. When taken with meals, sevelamer binds to dietary phosphate and prevents its absorption. It is marketed by Genzyme under the trade name Renagel.
DrugDrug NamePhaseStatusCount
DB00796Candesartan cilexetil1Completed1
DB11634Colestilan chloride1Completed1
DB06792Lanthanum carbonate1Completed1
DB02701Nicotinamide1 / 2Completed1
DB06724Calcium Carbonate2Recruiting1
DB13949Ferric cation2Completed2
DB06792Lanthanum carbonate2Completed2
DB06792Lanthanum carbonate2Recruiting1
DB01373Calcium3Active Not Recruiting1
DB01373Calcium3Not Yet Recruiting1
DB00258Calcium Acetate3Completed2
DB00258Calcium Acetate3Not Yet Recruiting1
DB00258Calcium Acetate3Recruiting1
DB06724Calcium Carbonate3Active Not Recruiting1
DB06724Calcium Carbonate3Completed1
DB11634Colestilan chloride3Completed4
DB11634Colestilan chloride3Terminated3
DB13949Ferric cation3Active Not Recruiting1
DB13949Ferric cation3Completed4
DB09146Iron saccharate3Recruiting1
DB06792Lanthanum carbonate3Active Not Recruiting1
DB06792Lanthanum carbonate3Completed4
DB00658Sevelamer3Not Yet Recruiting1
DB01373Calcium4Enrolling by Invitation1
DB00258Calcium Acetate4Completed1
DB06724Calcium Carbonate4Completed1
DB06724Calcium Carbonate4Enrolling by Invitation1
DB06724Calcium Carbonate4Recruiting1
DB13949Ferric cation4Not Yet Recruiting1
DB13949Ferric cation4Recruiting2
DB06792Lanthanum carbonate4Enrolling by Invitation1
DB00627Niacin4Not Yet Recruiting1
DB01373CalciumNot AvailableWithdrawn1
DB00258Calcium AcetateNot AvailableWithdrawn1
DB06724Calcium CarbonateNot AvailableWithdrawn1
DB09146Iron saccharateNot AvailableRecruiting2
DB06792Lanthanum carbonateNot AvailableCompleted2
DB00658SevelamerNot AvailableActive Not Recruiting1
DB00658SevelamerNot AvailableCompleted1
DB00658SevelamerNot AvailableRecruiting1
DB00658SevelamerNot AvailableWithdrawn2