Skin Irritation

Also known as: Skin irritants / Itch / Irritation skin

DrugDrug NameDrug Description
DB06723Aluminum hydroxideAn antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.
DB01086BenzocaineA topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations.
DB01744CamphorA compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.
DB00527CinchocaineAn anesthetic used for local or regional anesthesia.
DB14005Dimethicone 410Dimethicone is approved as a transdermal drug delivery system. Dimethicone 410 is part of the simethicone element in Dow Corning Q7-2242 LVA which is an antifoam.[L2163, L2166] Some OTC's containing...
DB01075DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
DB00196FluconazoleA triazole antifungal used to treat various fungal infections including candidiasis.
DB14539Hydrocortisone acetateA corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses and ulcerative colitis.
DB14543Hydrocortisone probutateA corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
DB14545Hydrocortisone succinateA corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.
DB03796Palmitic AcidA fatty used as a food additive and emollient or surfactant in cosmetics.
DB09345PramocaineA local anesthetic and antipruritic agent found in various topical preparations.
DB01390Sodium bicarbonateA compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock.
DB09153Sodium chlorideAn ingredient found in a variety of nutritional products as a source of electrolytes and water.
DB01593ZincAn essential element commonly used for the treatment of patients with documented zinc deficiency.
DB14487Zinc acetateA medication used to treat zinc deficiency.
DB09321Zinc oxideA mineral ingredient of various pharmacological preparations to treat diaper dermatitis and other skin conditions, to protect the epidermis, and to prevent sunburn.
DrugDrug NameTargetType
DB01086BenzocaineSodium channel protein type 10 subunit alphatarget
DB01086BenzocaineP-glycoprotein 1transporter
DB01086BenzocaineLiver carboxylesterase 1enzyme
DB01744CamphorCamphor 5-monooxygenasetarget
DB01744CamphorTransient receptor potential cation channel subfamily V member 1target
DB01744CamphorTransient receptor potential cation channel subfamily V member 3target
DB01744CamphorTransient receptor potential cation channel subfamily A member 1target
DB01744CamphorTransient receptor potential cation channel subfamily M member 8target
DB00527CinchocaineSodium channel protein type 5 subunit alphatarget
DB00527CinchocaineSodium channel protein type 10 subunit alphatarget
DB00527CinchocaineCalmodulintarget
DB00527CinchocaineCholinesteraseenzyme
DB01075DiphenhydramineHistamine H1 receptortarget
DB01075DiphenhydramineCytochrome P450 2D6enzyme
DB01075DiphenhydramineCytochrome P450 2C9enzyme
DB01075DiphenhydramineCytochrome P450 2C19enzyme
DB01075DiphenhydramineSolute carrier family 22 member 2transporter
DB01075DiphenhydramineSolute carrier family 22 member 5transporter
DB01075DiphenhydramineProstaglandin G/H synthase 1enzyme
DB01075DiphenhydramineMuscarinic acetylcholine receptor M2target
DB00196FluconazoleCytochrome P450 3A4enzyme
DB00196FluconazoleCytochrome P450 2C9enzyme
DB00196FluconazoleCytochrome P450 2C19enzyme
DB00196FluconazoleP-glycoprotein 1transporter
DB00196FluconazoleCytochrome P450 51target
DB00196FluconazoleCytochrome P450 3A5enzyme
DB14539Hydrocortisone acetateAnnexin A1target
DB14539Hydrocortisone acetateGlucocorticoid receptortarget
DB14539Hydrocortisone acetateSex hormone-binding globulincarrier
DB14539Hydrocortisone acetateCytochrome P450 3A4enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A5enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A7enzyme
DB14539Hydrocortisone acetateP-glycoprotein 1transporter
DB14539Hydrocortisone acetateSolute carrier organic anion transporter family member 1A2transporter
DB14539Hydrocortisone acetateATP-binding cassette sub-family G member 2transporter
DB14539Hydrocortisone acetateCytochrome P450 11B1, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 11B2, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 2C8enzyme
DB14539Hydrocortisone acetateCorticosteroid-binding globulincarrier
DB14539Hydrocortisone acetateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14539Hydrocortisone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14539Hydrocortisone acetateSolute carrier family 22 member 8transporter
DB14543Hydrocortisone probutateAnnexin A1target
DB14543Hydrocortisone probutateGlucocorticoid receptortarget
DB14543Hydrocortisone probutateSex hormone-binding globulincarrier
DB14543Hydrocortisone probutateCytochrome P450 3A4enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A5enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A7enzyme
DB14543Hydrocortisone probutateP-glycoprotein 1transporter
DB14543Hydrocortisone probutateSolute carrier organic anion transporter family member 1A2transporter
DB14543Hydrocortisone probutateATP-binding cassette sub-family G member 2transporter
DB14543Hydrocortisone probutateCytochrome P450 11B1, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 11B2, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 2C8enzyme
DB14543Hydrocortisone probutateCorticosteroid-binding globulincarrier
DB14543Hydrocortisone probutateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14543Hydrocortisone probutate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14543Hydrocortisone probutateSolute carrier family 22 member 8transporter
DB14545Hydrocortisone succinateCytochrome P450 3A4enzyme
DB14545Hydrocortisone succinateCytochrome P450 2C8enzyme
DB14545Hydrocortisone succinateCytochrome P450 11B1, mitochondrialenzyme
DB14545Hydrocortisone succinateCytochrome P450 11B2, mitochondrialenzyme
DB03796Palmitic AcidRhodopsintarget
DB03796Palmitic AcidSerum albumincarrier
DB03796Palmitic AcidSEC14-like protein 2target
DB03796Palmitic AcidPalmitoyl-protein thioesterase 1target
DB03796Palmitic AcidMyelin P2 proteintarget
DB03796Palmitic AcidFatty acid-binding protein, adipocytecarrier
DB03796Palmitic AcidFatty acid-binding protein, epidermalcarrier
DB03796Palmitic AcidGlycodelintarget
DB03796Palmitic AcidFatty acid-binding protein, heartcarrier
DB03796Palmitic AcidHepatocyte nuclear factor 4-gammatarget
DB03796Palmitic AcidLipid binding proteintarget
DB03796Palmitic AcidCytochrome P450 2C8target
DB03796Palmitic AcidTrafficking protein particle complex subunit 3target
DB03796Palmitic AcidFatty acid-binding protein TM_1468target
DB03796Palmitic AcidFatty acid-binding protein, intestinalcarrier
DB03796Palmitic AcidAlpha-lactalbumintarget
DB03796Palmitic AcidPeroxisome proliferator-activated receptor alphatarget
DB09345PramocaineVoltage-gated sodium channel alpha subunittarget
DB01390Sodium bicarbonateElectrogenic sodium bicarbonate cotransporter 1transporter
DB01390Sodium bicarbonateSodium bicarbonate cotransporter 3transporter
DB01390Sodium bicarbonateElectroneutral sodium bicarbonate exchanger 1transporter
DB01390Sodium bicarbonateElectrogenic sodium bicarbonate cotransporter 4transporter
DB01390Sodium bicarbonateHydrogen ionstarget
DB01390Sodium bicarbonateSodium-driven chloride bicarbonate exchangertransporter
DB01593ZincB1 bradykinin receptortarget
DB01593ZincMethylated-DNA--protein-cysteine methyltransferasetarget
DB01593ZincFructose-bisphosphate aldolase Atarget
DB01593ZincElongation factor 1-alpha 1target
DB01593ZincAlpha-enolasetarget
DB01593ZincGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
DB01593ZincNucleoside diphosphate kinase Atarget
DB01593ZincProtein disulfide-isomerasetarget
DB01593ZincProtein disulfide-isomerase A3target
DB01593ZincPeroxiredoxin-1target
DB01593ZincPhosphoserine phosphatasetarget
DB01593ZincTriosephosphate isomerasetarget
DB01593ZincElongation factor Tu, mitochondrialtarget
DB01593ZincEstrogen receptor alphatarget
DB01593ZincInterleukin-3target
DB01593ZincMetallothionein-2target
DB01593ZincCopper chaperone for superoxide dismutasetarget
DB01593ZincHistone deacetylase 1target
DB01593ZincHistone deacetylase 4target
DB01593ZincDNA-3-methyladenine glycosylasetarget
DB01593ZincSemenogelin-1target
DB01593ZincSuperoxide dismutase [Cu-Zn]target
DB01593ZincHistone deacetylase 8target
DB01593ZincApoptosis regulatory protein Sivatarget
DB01593ZincGlycine receptor subunit alpha-1target
DB01593ZincE3 ubiquitin-protein ligase Mdm2target
DB01593ZincInsulintarget
DB01593ZincUtrophintarget
DB01593ZincAspartoacylasetarget
DB01593ZincProtein S100-A8target
DB01593ZincProtein S100-A9target
DB01593ZincMatrix metalloproteinase-9target
DB01593ZincTumor protein p73target
DB01593ZincProtein S100-A2target
DB01593ZincCellular tumor antigen p53target
DB01593ZincMetallothionein-3target
DB01593ZincProgrammed cell death protein 6target
DB01593ZincDAN domain family member 5target
DB01593ZincMetallothionein-1Atarget
DB01593ZincAlpha-1B-glycoproteintarget
DB01593ZincAlpha-2-macroglobulintarget
DB01593ZincAngiotensinogentarget
DB01593ZincAlpha-2-HS-glycoproteintarget
DB01593ZincSerum amyloid P-componenttarget
DB01593ZincApolipoprotein A-Itarget
DB01593ZincApolipoprotein A-IItarget
DB01593ZincApolipoprotein A-IVtarget
DB01593ZincApolipoprotein B receptortarget
DB01593ZincApolipoprotein Etarget
DB01593ZincApolipoprotein L1target
DB01593ZincComplement C1q subcomponent subunit Btarget
DB01593ZincComplement C1q subcomponent subunit Ctarget
DB01593ZincComplement C1r subcomponenttarget
DB01593ZincComplement C1s subcomponenttarget
DB01593ZincComplement C3target
DB01593ZincComplement C4-Btarget
DB01593ZincC4b-binding protein alpha chaintarget
DB01593ZincC4b-binding protein beta chaintarget
DB01593ZincComplement C5target
DB01593ZincLys-63-specific deubiquitinase BRCC36target
DB01593ZincComplement component C8 alpha chaintarget
DB01593ZincComplement component C8 beta chaintarget
DB01593ZincComplement component C8 gamma chaintarget
DB01593ZincComplement factor Btarget
DB01593ZincComplement factor Htarget
DB01593ZincComplement factor Itarget
DB01593ZincClusterintarget
DB01593ZincCeruloplasmintarget
DB01593ZincCarboxypeptidase N catalytic chaintarget
DB01593ZincCarboxypeptidase N subunit 2target
DB01593ZincDermcidintarget
DB01593ZincDesmoplakintarget
DB01593ZincCoagulation factor XIItarget
DB01593ZincCoagulation factor XIII B chaintarget
DB01593ZincProthrombintarget
DB01593ZincFicolin-3target
DB01593ZincFibrinogen alpha chaintarget
DB01593ZincFibronectintarget
DB01593ZincGelsolintarget
DB01593ZincHemoglobin subunit alphatarget
DB01593ZincHemoglobin subunit betatarget
DB01593ZincHaptoglobin-related proteintarget
DB01593ZincHornerintarget
DB01593ZincInsulin-like growth factor-binding protein complex acid labile subunittarget
DB01593ZincIg alpha-1 chain C regiontarget
DB01593ZincIg mu chain C regiontarget
DB01593ZincImmunoglobulin kappa variable 1-17target
DB01593ZincIg kappa chain V-III region GOLtarget
DB01593ZincImmunoglobulin lambda variable 3-21target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H1target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H2target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H3target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H4target
DB01593ZincImmunoglobulin J chaintarget
DB01593ZincJunction plakoglobintarget
DB01593ZincPlasma kallikreintarget
DB01593ZincKininogen-1target
DB01593ZincKeratin, type II cytoskeletal 1target
DB01593ZincKeratin, type I cytoskeletal 10target
DB01593ZincKeratin, type I cytoskeletal 14target
DB01593ZincKeratin, type I cytoskeletal 16target
DB01593ZincKeratin, type II cytoskeletal 2 epidermaltarget
DB01593ZincKeratin, type II cytoskeletal 5target
DB01593ZincKeratin, type II cytoskeletal 6Atarget
DB01593ZincKeratin, type I cytoskeletal 9target
DB01593ZincAlpha-1-acid glycoprotein 2target
DB01593ZincN-acetylmuramoyl-L-alanine amidasetarget
DB01593ZincSerum paraoxonase/arylesterase 1target
DB01593ZincPregnancy zone proteintarget
DB01593ZincProtein S100-A7target
DB01593ZincSelenoprotein Ptarget
DB01593ZincAlpha-1-antitrypsintarget
DB01593ZincAlpha-1-antichymotrypsintarget
DB01593ZincKallistatintarget
DB01593ZincCorticosteroid-binding globulintarget
DB01593ZincHeparin cofactor 2target
DB01593ZincSex hormone-binding globulintarget
DB01593ZincSerotransferrintarget
DB01593ZincTransthyretintarget
DB01593ZincVitronectintarget
DB01593ZincAmyloid-like protein 1target
DB01593ZincAmyloid-like protein 2target
DB01593ZincAmyloid beta A4 proteintarget
DB01593ZincPoly [ADP-ribose] polymerase 1target
DB01593ZincCarbonic anhydrase 1enzyme
DB14487Zinc acetateB1 bradykinin receptortarget
DB14487Zinc acetateMethylated-DNA--protein-cysteine methyltransferasetarget
DB14487Zinc acetateFructose-bisphosphate aldolase Atarget
DB14487Zinc acetateElongation factor 1-alpha 1target
DB14487Zinc acetateAlpha-enolasetarget
DB14487Zinc acetateGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
DB14487Zinc acetateNucleoside diphosphate kinase Atarget
DB14487Zinc acetateProtein disulfide-isomerasetarget
DB14487Zinc acetateProtein disulfide-isomerase A3target
DB14487Zinc acetatePeroxiredoxin-1target
DB14487Zinc acetatePhosphoserine phosphatasetarget
DB14487Zinc acetateTriosephosphate isomerasetarget
DB14487Zinc acetateElongation factor Tu, mitochondrialtarget
DB14487Zinc acetateEstrogen receptor alphatarget
DB14487Zinc acetateInterleukin-3target
DB14487Zinc acetateMetallothionein-2target
DB14487Zinc acetateCopper chaperone for superoxide dismutasetarget
DB14487Zinc acetateHistone deacetylase 1target
DB14487Zinc acetateHistone deacetylase 4target
DB14487Zinc acetateDNA-3-methyladenine glycosylasetarget
DB14487Zinc acetateSemenogelin-1target
DB14487Zinc acetateSuperoxide dismutase [Cu-Zn]target
DB14487Zinc acetateHistone deacetylase 8target
DB14487Zinc acetateApoptosis regulatory protein Sivatarget
DB14487Zinc acetateGlycine receptor subunit alpha-1target
DB14487Zinc acetateE3 ubiquitin-protein ligase Mdm2target
DB14487Zinc acetateInsulintarget
DB14487Zinc acetateUtrophintarget
DB14487Zinc acetateAspartoacylasetarget
DB14487Zinc acetateProtein S100-A8target
DB14487Zinc acetateProtein S100-A9target
DB14487Zinc acetateMatrix metalloproteinase-9target
DB14487Zinc acetateTumor protein p73target
DB14487Zinc acetateProtein S100-A2target
DB14487Zinc acetateCellular tumor antigen p53target
DB14487Zinc acetateMetallothionein-3target
DB14487Zinc acetateProgrammed cell death protein 6target
DB14487Zinc acetateDAN domain family member 5target
DB14487Zinc acetateMetallothionein-1Atarget
DB14487Zinc acetateAlpha-1B-glycoproteintarget
DB14487Zinc acetateAlpha-2-macroglobulintarget
DB14487Zinc acetateAngiotensinogentarget
DB14487Zinc acetateAlpha-2-HS-glycoproteintarget
DB14487Zinc acetateSerum amyloid P-componenttarget
DB14487Zinc acetateApolipoprotein A-Itarget
DB14487Zinc acetateApolipoprotein A-IItarget
DB14487Zinc acetateApolipoprotein A-IVtarget
DB14487Zinc acetateApolipoprotein B receptortarget
DB14487Zinc acetateApolipoprotein Etarget
DB14487Zinc acetateApolipoprotein L1target
DB14487Zinc acetateComplement C1q subcomponent subunit Btarget
DB14487Zinc acetateComplement C1q subcomponent subunit Ctarget
DB14487Zinc acetateComplement C1r subcomponenttarget
DB14487Zinc acetateComplement C1s subcomponenttarget
DB14487Zinc acetateComplement C3target
DB14487Zinc acetateComplement C4-Btarget
DB14487Zinc acetateC4b-binding protein alpha chaintarget
DB14487Zinc acetateC4b-binding protein beta chaintarget
DB14487Zinc acetateComplement C5target
DB14487Zinc acetateLys-63-specific deubiquitinase BRCC36target
DB14487Zinc acetateComplement component C8 alpha chaintarget
DB14487Zinc acetateComplement component C8 beta chaintarget
DB14487Zinc acetateComplement component C8 gamma chaintarget
DB14487Zinc acetateComplement factor Btarget
DB14487Zinc acetateComplement factor Htarget
DB14487Zinc acetateComplement factor Itarget
DB14487Zinc acetateClusterintarget
DB14487Zinc acetateCeruloplasmintarget
DB14487Zinc acetateCarboxypeptidase N catalytic chaintarget
DB14487Zinc acetateCarboxypeptidase N subunit 2target
DB14487Zinc acetateDermcidintarget
DB14487Zinc acetateDesmoplakintarget
DB14487Zinc acetateCoagulation factor XIItarget
DB14487Zinc acetateCoagulation factor XIII B chaintarget
DB14487Zinc acetateProthrombintarget
DB14487Zinc acetateFicolin-3target
DB14487Zinc acetateFibrinogen alpha chaintarget
DB14487Zinc acetateFibronectintarget
DB14487Zinc acetateGelsolintarget
DB14487Zinc acetateHemoglobin subunit alphatarget
DB14487Zinc acetateHemoglobin subunit betatarget
DB14487Zinc acetateHaptoglobin-related proteintarget
DB14487Zinc acetateHornerintarget
DB14487Zinc acetateInsulin-like growth factor-binding protein complex acid labile subunittarget
DB14487Zinc acetateIg alpha-1 chain C regiontarget
DB14487Zinc acetateIg mu chain C regiontarget
DB14487Zinc acetateImmunoglobulin kappa variable 1-17target
DB14487Zinc acetateIg kappa chain V-III region GOLtarget
DB14487Zinc acetateImmunoglobulin lambda variable 3-21target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H1target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H2target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H3target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H4target
DB14487Zinc acetateImmunoglobulin J chaintarget
DB14487Zinc acetateJunction plakoglobintarget
DB14487Zinc acetatePlasma kallikreintarget
DB14487Zinc acetateKininogen-1target
DB14487Zinc acetateKeratin, type II cytoskeletal 1target
DB14487Zinc acetateKeratin, type I cytoskeletal 10target
DB14487Zinc acetateKeratin, type I cytoskeletal 14target
DB14487Zinc acetateKeratin, type I cytoskeletal 16target
DB14487Zinc acetateKeratin, type II cytoskeletal 2 epidermaltarget
DB14487Zinc acetateKeratin, type II cytoskeletal 5target
DB14487Zinc acetateKeratin, type II cytoskeletal 6Atarget
DB14487Zinc acetateKeratin, type I cytoskeletal 9target
DB14487Zinc acetateAlpha-1-acid glycoprotein 2target
DB14487Zinc acetateN-acetylmuramoyl-L-alanine amidasetarget
DB14487Zinc acetateSerum paraoxonase/arylesterase 1target
DB14487Zinc acetatePregnancy zone proteintarget
DB14487Zinc acetateProtein S100-A7target
DB14487Zinc acetateSelenoprotein Ptarget
DB14487Zinc acetateAlpha-1-antitrypsintarget
DB14487Zinc acetateAlpha-1-antichymotrypsintarget
DB14487Zinc acetateKallistatintarget
DB14487Zinc acetateCorticosteroid-binding globulintarget
DB14487Zinc acetateHeparin cofactor 2target
DB14487Zinc acetateSex hormone-binding globulintarget
DB14487Zinc acetateSerotransferrintarget
DB14487Zinc acetateTransthyretintarget
DB14487Zinc acetateVitronectintarget
DB14487Zinc acetateAmyloid-like protein 1target
DB14487Zinc acetateAmyloid-like protein 2target
DB14487Zinc acetateAmyloid beta A4 proteintarget
DB14487Zinc acetatePoly [ADP-ribose] polymerase 1target
DB14487Zinc acetateCarbonic anhydrase 1enzyme
DB14487Zinc acetateCarboxypeptidase Eenzyme
DB14487Zinc acetateAlcohol dehydrogenase 1Cenzyme
DB14487Zinc acetateInsulin-degrading enzymeenzyme
DB14487Zinc acetateSuperoxide dismutase [Cu-Zn]enzyme
DrugDrug NamePhaseStatusCount
DB00888Mechlorethamine0Recruiting1
DB00343Diltiazem1Unknown Status1
DB00843Donepezil1Completed1
DB00815Sodium lauryl sulfate1Unknown Status1
DB08604Triclosan4Completed1