Skin Irritation

Also known as: Skin irritants / Itch / Irritation skin

DrugDrug NameDrug Description
DB06723Aluminum hydroxideAluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
DB01086BenzocaineA surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. [PubChem]
DB01744CamphorA bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora. It is used topically as a skin antipruritic and as an anti-infective agent.
DB00527CinchocaineA local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
DB01075DiphenhydramineA histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
DB03796Palmitic AcidA common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids. [PubChem]
DB09345PramocainePramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications in various topical preparations. It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation.
DB09153Sodium ChlorideSodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. Sodium chloride is the salt most responsible for the salinity of seawater and of the extracellular fluid of many multicellular organisms. It is listed on the World Health Organization Model List of Essential Medicines.
DB01390Sodium bicarbonateSodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
DB01593ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is known by the symbol Zn.
DB09321Zinc oxideZinc oxide is an inorganic compound with the formula ZnO. ZnO is a white powder that is insoluble in water, and it is widely used as an additive in numerous materials and products including rubbers, plastics, ceramics, glass, cement, lubricants, paints, ointments, adhesives, sealants, pigments, foods, batteries, ferrites, fire retardants, and first-aid tapes. It occurs naturally as the mineral zincite, but most zinc oxide is produced synthetically. It is also widely used to treat a variety of other skin conditions, in products such as baby powder and barrier creams to treat diaper rashes, calamine cream, anti-dandruff shampoos, and antiseptic ointments.
DrugDrug NameTargetType
DB01086BenzocaineSodium channel protein type 10 subunit alphatarget
DB01086BenzocaineMultidrug resistance protein 1transporter
DB01086BenzocaineLiver carboxylesterase 1enzyme
DB01744CamphorCamphor 5-monooxygenasetarget
DB00527CinchocaineSodium channel protein type 5 subunit alphatarget
DB00527CinchocaineSodium channel protein type 10 subunit alphatarget
DB00527CinchocaineCalmodulintarget
DB00527CinchocaineCholinesteraseenzyme
DB01075DiphenhydramineCytochrome P450 2D6enzyme
DB01075DiphenhydramineCytochrome P450 1A2enzyme
DB01075DiphenhydramineCytochrome P450 2C9enzyme
DB01075DiphenhydramineCytochrome P450 2C19enzyme
DB01075DiphenhydramineCytochrome P450 2C18enzyme
DB01075DiphenhydramineCytochrome P450 2B6enzyme
DB01075DiphenhydramineProstaglandin G/H synthase 1enzyme
DB01075DiphenhydramineHistamine H1 receptortarget
DB01075DiphenhydramineMuscarinic acetylcholine receptor M2target
DB01075DiphenhydramineSolute carrier family 22 member 2transporter
DB01075DiphenhydramineSolute carrier family 22 member 1transporter
DB01075DiphenhydramineSolute carrier family 22 member 5transporter
DB03796Palmitic AcidSerum albumincarrier
DB03796Palmitic AcidFatty acid-binding protein, adipocytecarrier
DB03796Palmitic AcidFatty acid-binding protein, epidermalcarrier
DB03796Palmitic AcidFatty acid-binding protein, heartcarrier
DB03796Palmitic AcidFatty acid-binding protein, intestinalcarrier
DB03796Palmitic AcidRhodopsintarget
DB03796Palmitic AcidSEC14-like protein 2target
DB03796Palmitic AcidPalmitoyl-protein thioesterase 1target
DB03796Palmitic AcidMyelin P2 proteintarget
DB03796Palmitic AcidGlycodelintarget
DB03796Palmitic AcidHepatocyte nuclear factor 4-gammatarget
DB03796Palmitic AcidLipid binding proteintarget
DB03796Palmitic AcidCytochrome P450 2C8target
DB03796Palmitic AcidTrafficking protein particle complex subunit 3target
DB03796Palmitic AcidFatty acid-binding protein TM_1468target
DB03796Palmitic AcidAlpha-lactalbumintarget
DB03796Palmitic AcidPeroxisome proliferator-activated receptor alphatarget
DB03796Palmitic AcidMultidrug resistance protein 1transporter
DB09345PramocaineVoltage gated sodium channeltarget
DB01390Sodium bicarbonateElectrogenic sodium bicarbonate cotransporter 1transporter
DB01390Sodium bicarbonateSodium bicarbonate cotransporter 3transporter
DB01390Sodium bicarbonateElectroneutral sodium bicarbonate exchanger 1transporter
DB01390Sodium bicarbonateElectrogenic sodium bicarbonate cotransporter 4transporter
DB01390Sodium bicarbonateHydrogen ionstarget
DB01390Sodium bicarbonateSodium-driven chloride bicarbonate exchangertransporter
DB01593ZincB1 bradykinin receptortarget
DB01593ZincMethylated-DNA--protein-cysteine methyltransferasetarget
DB01593ZincFructose-bisphosphate aldolase Atarget
DB01593ZincElongation factor 1-alpha 1target
DB01593ZincAlpha-enolasetarget
DB01593ZincGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
DB01593ZincNucleoside diphosphate kinase Atarget
DB01593ZincProtein disulfide-isomerasetarget
DB01593ZincProtein disulfide-isomerase A3target
DB01593ZincPeroxiredoxin-1target
DB01593ZincPhosphoserine phosphatasetarget
DB01593ZincTriosephosphate isomerasetarget
DB01593ZincElongation factor Tu, mitochondrialtarget
DB01593ZincEstrogen receptor alphatarget
DB01593ZincInterleukin-3target
DB01593ZincMetallothionein-2target
DB01593ZincCopper chaperone for superoxide dismutasetarget
DB01593ZincHistone deacetylase 1target
DB01593ZincHistone deacetylase 4target
DB01593ZincDNA-3-methyladenine glycosylasetarget
DB01593ZincSemenogelin-1target
DB01593ZincSuperoxide dismutase [Cu-Zn]target
DB01593ZincHistone deacetylase 8target
DB01593ZincApoptosis regulatory protein Sivatarget
DB01593ZincGlycine receptor subunit alpha-1target
DB01593ZincE3 ubiquitin-protein ligase Mdm2target
DB01593ZincInsulintarget
DB01593ZincUtrophintarget
DB01593ZincAspartoacylasetarget
DB01593ZincProtein S100-A8target
DB01593ZincProtein S100-A9target
DB01593ZincMatrix metalloproteinase-9target
DB01593ZincTumor protein p73target
DB01593ZincProtein S100-A2target
DB01593ZincCellular tumor antigen p53target
DB01593ZincMetallothionein-3target
DB01593ZincProgrammed cell death protein 6target
DB01593ZincDAN domain family member 5target
DB01593ZincMetallothionein-1Atarget
DB01593ZincAlpha-1B-glycoproteintarget
DB01593ZincAlpha-2-macroglobulintarget
DB01593ZincAngiotensinogentarget
DB01593ZincAlpha-2-HS-glycoproteintarget
DB01593ZincSerum amyloid P-componenttarget
DB01593ZincApolipoprotein A-Itarget
DB01593ZincApolipoprotein A-IItarget
DB01593ZincApolipoprotein A-IVtarget
DB01593ZincApolipoprotein B receptortarget
DB01593ZincApolipoprotein Etarget
DB01593ZincApolipoprotein L1target
DB01593ZincComplement C1q subcomponent subunit Btarget
DB01593ZincComplement C1q subcomponent subunit Ctarget
DB01593ZincComplement C1r subcomponenttarget
DB01593ZincComplement C1s subcomponenttarget
DB01593ZincComplement C3target
DB01593ZincComplement C4-Btarget
DB01593ZincC4b-binding protein alpha chaintarget
DB01593ZincC4b-binding protein beta chaintarget
DB01593ZincComplement C5target
DB01593ZincLys-63-specific deubiquitinase BRCC36target
DB01593ZincComplement component C8 alpha chaintarget
DB01593ZincComplement component C8 beta chaintarget
DB01593ZincComplement component C8 gamma chaintarget
DB01593ZincComplement factor Btarget
DB01593ZincComplement factor Htarget
DB01593ZincComplement factor Itarget
DB01593ZincClusterintarget
DB01593ZincCeruloplasmintarget
DB01593ZincCarboxypeptidase N catalytic chaintarget
DB01593ZincCarboxypeptidase N subunit 2target
DB01593ZincDermcidintarget
DB01593ZincDesmoplakintarget
DB01593ZincCoagulation factor XIItarget
DB01593ZincCoagulation factor XIII B chaintarget
DB01593ZincProthrombintarget
DB01593ZincFicolin-3target
DB01593ZincFibrinogen alpha chaintarget
DB01593ZincFibronectintarget
DB01593ZincGelsolintarget
DB01593ZincHemoglobin subunit alphatarget
DB01593ZincHemoglobin subunit betatarget
DB01593ZincHaptoglobin-related proteintarget
DB01593ZincHornerintarget
DB01593ZincInsulin-like growth factor-binding protein complex acid labile subunittarget
DB01593ZincIg alpha-1 chain C regiontarget
DB01593ZincIg mu chain C regiontarget
DB01593ZincImmunoglobulin kappa variable 1-17target
DB01593ZincIg kappa chain V-III region GOLtarget
DB01593ZincImmunoglobulin lambda variable 3-21target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H1target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H2target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H3target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H4target
DB01593ZincImmunoglobulin J chaintarget
DB01593ZincJunction plakoglobintarget
DB01593ZincPlasma kallikreintarget
DB01593ZincKininogen-1target
DB01593ZincKeratin, type II cytoskeletal 1target
DB01593ZincKeratin, type I cytoskeletal 10target
DB01593ZincKeratin, type I cytoskeletal 14target
DB01593ZincKeratin, type I cytoskeletal 16target
DB01593ZincKeratin, type II cytoskeletal 2 epidermaltarget
DB01593ZincKeratin, type II cytoskeletal 5target
DB01593ZincKeratin, type II cytoskeletal 6Atarget
DB01593ZincKeratin, type I cytoskeletal 9target
DB01593ZincAlpha-1-acid glycoprotein 2target
DB01593ZincN-acetylmuramoyl-L-alanine amidasetarget
DB01593ZincSerum paraoxonase/arylesterase 1target
DB01593ZincPregnancy zone proteintarget
DB01593ZincProtein S100-A7target
DB01593ZincSelenoprotein Ptarget
DB01593ZincAlpha-1-antitrypsintarget
DB01593ZincAlpha-1-antichymotrypsintarget
DB01593ZincKallistatintarget
DB01593ZincCorticosteroid-binding globulintarget
DB01593ZincHeparin cofactor 2target
DB01593ZincSex hormone-binding globulintarget
DB01593ZincSerotransferrintarget
DB01593ZincTransthyretintarget
DB01593ZincVitronectintarget
DB01593ZincAmyloid-like protein 1target
DB01593ZincAmyloid-like protein 2target
DB01593ZincAmyloid beta A4 proteintarget
DB01593ZincPoly [ADP-ribose] polymerase 1target
DrugDrug NamePhaseStatusCount
DB00888Mechlorethamine0Recruiting1
DB00343Diltiazem1Unknown Status1
DB00815Sodium lauryl sulfate1Unknown Status1