Beta-2 adrenergic receptor

Details

Name
Beta-2 adrenergic receptor
Synonyms
  • ADRB2R
  • B2AR
  • Beta-2 adrenoceptor
  • Beta-2 adrenoreceptor
Gene Name
ADRB2
Organism
Human
Amino acid sequence
>lcl|BSEQ0037061|Beta-2 adrenergic receptor
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
Number of residues
413
Molecular Weight
46458.32
Theoretical pI
7.44
GO Classification
Functions
drug binding / potassium channel regulator activity / dopamine binding / beta2-adrenergic receptor activity / protein homodimerization activity / epinephrine binding / norepinephrine binding
Processes
negative regulation of ossification / synaptic transmission, glutamatergic / estrous cycle / positive regulation of protein ubiquitination / activation of adenylate cyclase activity / negative regulation of smooth muscle contraction / adenylate cyclase-activating adrenergic receptor signaling pathway / female pregnancy / activation of transmembrane receptor protein tyrosine kinase activity / positive regulation of transcription from RNA polymerase II promoter / desensitization of G-protein coupled receptor protein signaling pathway by arrestin / brown fat cell differentiation / response to testosterone / wound healing / positive regulation of autophagosome maturation / diet induced thermogenesis / associative learning / bone resorption / excitatory postsynaptic potential / cell surface receptor signaling pathway / positive regulation of lipophagy / heat generation / positive regulation of potassium ion transport / diaphragm contraction / positive regulation of cell proliferation / positive regulation of skeletal muscle tissue growth / negative regulation of multicellular organism growth / positive regulation of sodium ion transport / negative regulation of angiogenesis / regulation of sensory perception of pain / response to estrogen / positive regulation of the force of heart contraction by epinephrine / response to cold / cellular response to hypoxia / response to dexamethasone / positive regulation of MAPK cascade / cell-cell signaling / response to monoamine / vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure / positive regulation of bone mineralization / negative regulation of platelet aggregation / negative regulation of inflammatory response / mitophagy in response to mitochondrial depolarization / aging / positive regulation of apoptotic process / liver regeneration / positive regulation of vasodilation / adenylate cyclase-modulating G-protein coupled receptor signaling pathway / endosome to lysosome transport / regulation of calcium ion transport / response to progesterone / negative regulation of urine volume / receptor-mediated endocytosis / positive regulation of ATPase activity
Components
nucleus / neuronal cell body membrane / plasma membrane / dendritic spine / receptor complex / sarcolemma / lysosome / endosome / axon / early endosome / apical plasma membrane / integral component of plasma membrane
General Function
Protein homodimerization activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Pfam Domain Function
Transmembrane Regions
35-58 72-95 107-129 151-174 197-220 275-298 306-329
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0020478|Beta-2 adrenergic receptor (ADRB2)
ATGGGGCAACCCGGGAACGGCAGCGCCTTCTTGCTGGCACCCAATAGAAGCCATGCGCCG
GACCACGACGTCACGCAGCAAAGGGACGAGGTGTGGGTGGTGGGCATGGGCATCGTCATG
TCTCTCATCGTCCTGGCCATCGTGTTTGGCAATGTGCTGGTCATCACAGCCATTGCCAAG
TTCGAGCGTCTGCAGACGGTCACCAACTACTTCATCACTTCACTGGCCTGTGCTGATCTG
GTCATGGGCCTGGCAGTGGTGCCCTTTGGGGCCGCCCATATTCTTATGAAAATGTGGACT
TTTGGCAACTTCTGGTGCGAGTTTTGGACTTCCATTGATGTGCTGTGCGTCACGGCCAGC
ATTGAGACCCTGTGCGTGATCGCAGTGGATCGCTACTTTGCCATTACTTCACCTTTCAAG
TACCAGAGCCTGCTGACCAAGAATAAGGCCCGGGTGATCATTCTGATGGTGTGGATTGTG
TCAGGCCTTACCTCCTTCTTGCCCATTCAGATGCACTGGTACCGGGCCACCCACCAGGAA
GCCATCAACTGCTATGCCAATGAGACCTGCTGTGACTTCTTCACGAACCAAGCCTATGCC
ATTGCCTCTTCCATCGTGTCCTTCTACGTTCCCCTGGTGATCATGGTCTTCGTCTACTCC
AGGGTCTTTCAGGAGGCCAAAAGGCAGCTCCAGAAGATTGACAAATCTGAGGGCCGCTTC
CATGTCCAGAACCTTAGCCAGGTGGAGCAGGATGGGCGGACGGGGCATGGACTCCGCAGA
TCTTCCAAGTTCTGCTTGAAGGAGCACAAAGCCCTCAAGACGTTAGGCATCATCATGGGC
ACTTTCACCCTCTGCTGGCTGCCCTTCTTCATCGTTAACATTGTGCATGTGATCCAGGAT
AACCTCATCCGTAAGGAAGTTTACATCCTCCTAAATTGGATAGGCTATGTCAATTCTGGT
TTCAATCCCCTTATCTACTGCCGGAGCCCAGATTTCAGGATTGCCTTCCAGGAGCTTCTG
TGCCTGCGCAGGTCTTCTTTGAAGGCCTATGGGAATGGCTACTCCAGCAACGGCAACACA
GGGGAGCAGAGTGGATATCACGTGGAACAGGAGAAAGAAAATAAACTGCTGTGTGAAGAC
CTCCCAGGCACGGAAGACTTTGTGGGCCATCAAGGTACTGTGCCTAGCGATAACATTGAT
TCACAAGGGAGGAATTGTAGTACAAATGACTCACTGCTGTAA
Chromosome Location
5
Locus
5q31-q32
External Identifiers
ResourceLink
UniProtKB IDP07550
UniProtKB Entry NameADRB2_HUMAN
GenBank Protein ID29371
GenBank Gene IDY00106
GenAtlas IDADRB2
HGNC IDHGNC:286
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00521CarteololapprovedyesantagonistDetails
DB00816OrciprenalineapprovedyesagonistDetails
DB00867Ritodrineapproved, investigationalyesagonistDetails
DB00871TerbutalineapprovedyesagonistDetails
DB00901BitolterolwithdrawnyesDetails
DB00938SalmeterolapprovedyesagonistDetails
DB00983Formoterolapproved, investigationalyesagonistDetails
DB01001Salbutamolapproved, vet_approvedyesagonistDetails
DB00373TimololapprovedyesantagonistDetails
DB00571Propranololapproved, investigationalunknownantagonistDetails
DB00598LabetalolapprovedyesantagonistDetails
DB00612BisoprololapprovednoantagonistDetails
DB00668Epinephrineapproved, vet_approvedyesagonistDetails
DB00852Pseudoephedrineapprovedunknownpartial agonistDetails
DB00866Alprenololexperimental, withdrawnyesantagonistDetails
DB00960Pindololapproved, investigationalyespartial agonistDetails
DB01064Isoprenalineapproved, investigationalyesagonistDetails
DB01151Desipramineapproved, investigationalunknownantagonistDetails
DB01203NadololapprovedunknownantagonistDetails
DB01210LevobunololapprovedyesantagonistDetails
DB01214MetipranololapprovedyesantagonistDetails
DB01274Arformoterolapproved, investigationalyesagonistDetails
DB01366Procaterolapproved, investigationalyesagonistDetails
DB01407Clenbuterolapproved, investigational, vet_approvedyesagonistDetails
DB01136Carvedilolapproved, investigationalunknownantagonistDetails
DB01288Fenoterolapproved, investigationalyesagonistDetails
DB01291PirbuterolapprovedyesagonistDetails
DB01580OxprenololapprovedunknownantagonistDetails
DB01359Penbutololapproved, investigationalyesantagonistpartial agonistDetails
DB00368NorepinephrineapprovedyesagonistDetails
DB01408BambuterolinvestigationalyesagonistDetails
DB05039IndacaterolapprovedyesagonistDetails
DB05849NCX 950investigationalunknownDetails
DB06262Droxidopaapproved, investigationalyesagonistDetails
DB00264Metoprololapproved, investigationalunknownantagonistDetails
DB00195Betaxololapproved, investigationalunknownantagonistDetails
DB00489SotalolapprovedyesantagonistDetails
DB01295BevantololexperimentalunknownantagonistDetails
DB01193Acebutololapproved, investigationalunknownpartial agonistDetails
DB01102ArbutamineapprovedunknownagonistDetails
DB00841DobutamineapprovedunknownagonistDetails
DB07543(2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-olexperimentalunknownDetails
DB00449DipivefrinapprovedyesagonistDetails
DB08807Bopindololexperimentalunknownpartial agonistDetails
DB08808BupranololexperimentalunknownantagonistDetails
DB04861Nebivololapproved, investigationalunknownantagonistDetails
DB00925PhenoxybenzamineapprovedunknownDetails
DB01363Ephedraapproved, nutraceutical, withdrawnyesagonistDetails
DB06216AsenapineapprovedunknownantagonistDetails
DB00370MirtazapineapprovedunknownbinderDetails
DB00248CabergolineapprovedunknownbinderDetails
DB00221IsoetarineapprovedunknownagonistDetails
DB00335AtenololapprovedunknowninhibitorDetails
DB00397Phenylpropanolamineapproved, vet_approved, withdrawnunknownagonistDetails
DB09080OlodaterolapprovedyesagonistDetails
DB09082VilanterolapprovedyesagonistDetails
DB04846Celiprololapproved, investigationalyesagonistDetails
DB13139Levosalbutamolapproved, investigationalyesagonistDetails
DB09013BefunololexperimentalunknownDetails
DB12248TulobuterolinvestigationalunknownDetails
DB01917PutrescineexperimentalunknownDetails
DB03566SpermidineexperimentalunknownDetails
DB00127Spermineexperimental, nutraceuticalunknownDetails
DB01182PropafenoneapprovedunknownantagonistDetails
DB09204ArotinololinvestigationalyesantagonistDetails
DB09273DoxofyllineexperimentalyesagonistDetails
DB06814Protokylolapproved, vet_approvedyesagonistDetails
DB11124RacepinephrineapprovedyesagonistDetails
DB11587EtafedrineapprovedyesagonistDetails
DB00182Amphetamineapproved, illicit, investigationalunknownagonistDetails
DB00540NortriptylineapprovedunknownantagonistDetails
DB00726TrimipramineapprovedunknownbinderDetails
DB00334Olanzapineapproved, investigationalunknowninhibitorDetails
DB00217BethanidineapprovedunknownantagonistDetails
DB00321AmitriptylineapprovedunknownbinderDetails
DB01365MephentermineapprovedunknownagonistDetails
DB06726Bufuralolexperimental, investigationalunknownantagonistDetails
DB13345Dihydroergocristineapproved, experimentalyesantagonistagonistDetails
DB01049Ergoloid mesylateapprovedyesantagonistagonistDetails
DB11273DihydroergocornineapprovedyesantagonistagonistDetails
DB11278DL-MethylephedrineapprovedyesagonistDetails