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Identification
NameChlordiazepoxide
Accession NumberDB00475  (APRD00682)
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionAn anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. [PubChem]
Structure
Thumb
Synonyms
7-chloro-2-Methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide
CDP
Chloradiazepoxide
Chlordiazepoxide base
Chlordiazepoxidum
Clopoxide
Helogaphen
Libritabs
Methaminodiazepoxide
Multum
Risolid
Silibrin
Tropium
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ChlordiazepoxideCapsule5 mgOralAa Pharma Inc1981-12-31Not applicableCanada
ChlordiazepoxideCapsule10 mgOralAa Pharma Inc1981-12-31Not applicableCanada
ChlordiazepoxideCapsule25 mgOralAa Pharma Inc1981-12-31Not applicableCanada
Chlordiazepoxide Cap 10mgCapsule10 mgOralPro Doc Limitee1969-12-312010-07-13Canada
Chlordiazepoxide Cap 5mgCapsule5 mgOralPro Doc Limitee1976-12-312009-07-23Canada
Chlordiazepoxyde 25 CapCapsule25 mgOralDuchesnay Inc1981-12-312003-07-18Canada
Chlordiazepoxyde Cap 10mgCapsule10 mgOralDuchesnay Inc1978-12-312003-07-18Canada
Chlordiazepoxyde HCl Cap 25mgCapsule25 mgOralPro Doc Limitee1978-12-312010-07-13Canada
Corax Cap 10mgCapsule10 mgOralIcn Canada Ltd.1968-12-311998-08-13Canada
Corax Cap 25mgCapsule25 mgOralIcn Canada Ltd.1973-12-311998-08-13Canada
Corax Cap 5mgCapsule5 mgOralIcn Canada Ltd.1974-12-311998-08-13Canada
Medilium Cap 10 10mgCapsule10 mgOralMedic Laboratory LtÉe1970-12-311996-09-09Canada
Medilium Cap 5mgCapsule5 mgOralMedic Laboratory LtÉe1971-12-311996-09-09Canada
Novo-poxide 10mgCapsule10 mgOralNovopharm Limited1968-12-312005-08-10Canada
Novo-poxide 25mgCapsule25 mgOralNovopharm Limited1970-12-312005-08-10Canada
Novo-poxide 5mgCapsule5 mgOralNovopharm Limited1970-12-312005-08-10Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chlordiaze-poxide HClCapsule10 mg/1OralPd Rx Pharmaceuticals, Inc.2010-01-01Not applicableUs
ChlordiazepoxideCapsule25 mg/1OralDIRECT RX2016-03-04Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralCardinal Health2011-04-01Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralREMEDYREPACK INC.2011-08-012016-11-03Us
Chlordiazepoxide HydrochlorideCapsule10 mg/1OralMylan Institutional Inc.1996-03-05Not applicableUs
Chlordiazepoxide HydrochlorideCapsule, gelatin coated5 mg/1OralAv Kare, Inc.2002-09-26Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralREMEDYREPACK INC.2012-03-142016-10-15Us
Chlordiazepoxide HydrochlorideCapsule25 mg/1Oralbryant ranch prepack2010-12-06Not applicableUs
Chlordiazepoxide HydrochlorideCapsule, gelatin coated5 mg/1OralSolco Healthcare US LLC2010-05-15Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralREMEDYREPACK INC.2007-08-242016-11-22Us
Chlordiazepoxide HydrochlorideCapsule5 mg/1OralPhysicians Total Care, Inc.1993-01-01Not applicableUs
Chlordiazepoxide HydrochlorideCapsule10 mg/1OralREMEDYREPACK INC.2011-08-042015-12-29Us
Chlordiazepoxide HydrochlorideCapsule, gelatin coated5 mg/1OralGolden State Medical Supply, Inc.2010-05-15Not applicableUs
Chlordiazepoxide HydrochlorideCapsule5 mg/1OralREMEDYREPACK INC.2011-08-112016-10-13Us
Chlordiazepoxide HydrochlorideCapsule, gelatin coated10 mg/1OralAv Kare, Inc.2002-09-26Not applicableUs
Chlordiazepoxide HydrochlorideCapsule10 mg/1OralTeva Pharmaceuticals Usa, Inc.1990-09-30Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralA S Medication Solutions Llc1976-07-02Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralA S Medication Solutions Llc1976-07-02Not applicableUs
Chlordiazepoxide HydrochlorideCapsule10 mg/1Oralbryant ranch prepack1990-09-30Not applicableUs
Chlordiazepoxide HydrochlorideCapsule, gelatin coated10 mg/1OralSolco Healthcare US LLC2010-05-15Not applicableUs
Chlordiazepoxide HydrochlorideCapsule, gelatin coated10 mg/1OralAphena Pharma Solutions Tennessee, Llc2002-09-26Not applicableUs
Chlordiazepoxide HydrochlorideCapsule5 mg/1OralCardinal Health2011-04-01Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralREMEDYREPACK INC.2011-05-10Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralREMEDYREPACK INC.2016-11-23Not applicableUs
Chlordiazepoxide HydrochlorideCapsule, gelatin coated10 mg/1OralGolden State Medical Supply, Inc.2010-05-15Not applicableUs
Chlordiazepoxide HydrochlorideCapsule, gelatin coated25 mg/1OralAv Kare, Inc.2002-09-26Not applicableUs
Chlordiazepoxide HydrochlorideCapsule5 mg/1OralTeva Pharmaceuticals Usa, Inc.1976-07-01Not applicableUs
Chlordiazepoxide HydrochlorideCapsule10 mg/1OralPhysicians Total Care, Inc.1994-12-09Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralMylan Institutional Inc.1994-05-06Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralTYA Pharmaceuticals1976-07-02Not applicableUs
Chlordiazepoxide HydrochlorideCapsule10 mg/1OralCardinal Health2011-04-01Not applicableUs
Chlordiazepoxide HydrochlorideCapsule, gelatin coated25 mg/1OralSolco Healthcare US LLC2010-05-15Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralNu Care Pharmaceuticals, Inc.1976-07-02Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralREMEDYREPACK INC.2011-10-31Not applicableUs
Chlordiazepoxide HydrochlorideCapsule, gelatin coated25 mg/1OralGolden State Medical Supply, Inc.2010-05-15Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralPd Rx Pharmaceuticals, Inc.2010-12-06Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralTeva Pharmaceuticals Usa, Inc.1976-07-01Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralPhysicians Total Care, Inc.1993-03-24Not applicableUs
Chlordiazepoxide HydrochlorideCapsule25 mg/1OralContract Pharmacy Services Pa2010-04-07Not applicableUs
Chlordiazepoxide HydrochlorideCapsule5 mg/1OralMylan Institutional Inc.1995-12-08Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AngirexNot Available
EleniumPolfa Tarchomin
KlopoxidNycomed
LibriumAbbott
NapotonNot Available
RadepurAWD
RisolidActavis
SilibrinNot Available
SonimenNot Available
Brand mixtures
NameLabellerIngredients
ChloraxAa Pharma Inc
Chlordiazepoxide and Amitriptyline HClPar Pharmaceutical Inc
Chlordiazepoxide and Amitriptyline HydrochlorideMylan Pharmaceuticals Inc.
Chlordiazepoxide Hydrochloride and Clidinium BromideAcella Pharmaceuticals, LLC
Chlordiazepoxide Hydrochloride/clidinium BromideAv Kare, Inc.
Corium CapIcn Canada Ltd.
LibraxValeant Canada Lp Valeant Canada S.E.C.
Nu-chlorax Capsules USPNu Pharm Inc
Pro ChloraxPro Doc Limitee
Salts
Name/CASStructureProperties
Chlordiazepoxide Hydrochloride
438-41-5
Thumb
  • InChI Key: PRNVHVUEIITLRV-UHFFFAOYSA-N
  • Monoisotopic Mass: 335.059217531
  • Average Mass: 336.216
DBSALT000632
Categories
UNII6RZ6XEZ3CR
CAS number58-25-3
WeightAverage: 299.755
Monoisotopic: 299.082539792
Chemical FormulaC16H14ClN3O
InChI KeyANTSCNMPPGJYLG-UHFFFAOYSA-N
InChI
InChI=1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
IUPAC Name
7-chloro-2-(methylamino)-5-phenyl-3H-1,4λ⁵-benzodiazepin-4-one
SMILES
CNC1=NC2=C(C=C(Cl)C=C2)C(C2=CC=CC=C2)=N(=O)C1
Pharmacology
IndicationFor the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
Structured Indications
PharmacodynamicsChlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The drug seems to block EEG arousal from stimulation in the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.
Mechanism of actionChlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. This results in an increased binding of the inhibitory neurotransmitter GABA to the GABA(A) receptor.BZDs, therefore, enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.
TargetKindPharmacological actionActionsOrganismUniProt ID
GABA-A receptor (anion channel)Protein groupyes
positive allosteric modulator
Humannot applicabledetails
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic.

Route of eliminationChlordiazepoxide is excreted in the urine, with 1% to 2% unchanged and 3% to 6% as conjugate.
Half life24-48 hours
ClearanceNot Available
ToxicityLD50=537 mg/kg (Orally in rats). Signs of overdose include respiratory depression, muscle weakness, somnolence (general depressed activity).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with 1,1,1,2 Tetrafluoroethane.Investigational
7-NitroindazoleThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with 7-Nitroindazole.Experimental
AbirateroneThe serum concentration of Chlordiazepoxide can be increased when it is combined with Abiraterone.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Aceprometazine.Approved
adipiplonThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Alfentanil.Approved, Illicit
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chlordiazepoxide.Approved, Illicit, Investigational
Ambroxol acefyllinateThe therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Ambroxol acefyllinate.Experimental
AminophyllineThe therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Aminophylline.Approved
AmiodaroneThe metabolism of Chlordiazepoxide can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Amobarbital.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Amperozide.Experimental
AprepitantThe serum concentration of Chlordiazepoxide can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Aripiprazole.Approved, Investigational
ArtemetherThe metabolism of Chlordiazepoxide can be decreased when combined with Artemether.Approved
ArticaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Asenapine.Approved
AtazanavirThe metabolism of Chlordiazepoxide can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Chlordiazepoxide can be decreased when combined with Atomoxetine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Azaperone.Vet Approved
AzelastineChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Barbital.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Benzocaine.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Benzyl alcohol.Approved
BetaxololThe metabolism of Chlordiazepoxide can be decreased when combined with Betaxolol.Approved
BexaroteneThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Bexarotene.Approved, Investigational
BoceprevirThe metabolism of Chlordiazepoxide can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Chlordiazepoxide can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Bosentan.Approved, Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved
BromazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Bromazepam.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Brotizolam.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlordiazepoxide.Approved, Investigational
BuprenorphineChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Chlordiazepoxide can be decreased when combined with Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Buspirone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Chlordiazepoxide.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Butethal.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Butorphanol.Approved, Illicit, Vet Approved
CarbamazepineThe metabolism of Chlordiazepoxide can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Carfentanil.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Carisoprodol.Approved
CelecoxibThe metabolism of Chlordiazepoxide can be decreased when combined with Celecoxib.Approved, Investigational
CeritinibThe serum concentration of Chlordiazepoxide can be increased when it is combined with Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlormezanone.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chloroprocaine.Approved
ChloroquineThe metabolism of Chlordiazepoxide can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlorphenamine.Approved
ChlorpromazineThe metabolism of Chlordiazepoxide can be decreased when combined with Chlorpromazine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlorzoxazone.Approved
CholecalciferolThe metabolism of Chlordiazepoxide can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CimetidineThe metabolism of Chlordiazepoxide can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Chlordiazepoxide can be decreased when combined with Cinacalcet.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Cinchocaine.Approved, Vet Approved
CitalopramThe metabolism of Chlordiazepoxide can be decreased when combined with Citalopram.Approved
ClarithromycinThe metabolism of Chlordiazepoxide can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Chlordiazepoxide can be decreased when combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clidinium.Approved
ClobazamThe metabolism of Chlordiazepoxide can be decreased when combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with clomethiazole.Investigational
ClomipramineThe metabolism of Chlordiazepoxide can be decreased when combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clorazepate.Approved, Illicit
ClotrimazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clozapine.Approved
CobicistatThe serum concentration of Chlordiazepoxide can be increased when it is combined with Cobicistat.Approved
CocaineThe metabolism of Chlordiazepoxide can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Chlordiazepoxide.Approved, Illicit
ConivaptanThe serum concentration of Chlordiazepoxide can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of Chlordiazepoxide can be decreased when combined with Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Cyclobenzaprine.Approved
CyclosporineThe metabolism of Chlordiazepoxide can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Cyproheptadine.Approved
DabrafenibThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Dabrafenib.Approved
DantroleneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Chlordiazepoxide.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dapoxetine.Investigational
DarifenacinThe metabolism of Chlordiazepoxide can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Chlordiazepoxide can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Chlordiazepoxide can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Chlordiazepoxide can be decreased when combined with Delavirdine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Desflurane.Approved
DesipramineThe metabolism of Chlordiazepoxide can be decreased when combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Detomidine.Vet Approved
DexamethasoneThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dexmedetomidine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dezocine.Approved
DiazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Diazepam.Approved, Illicit, Vet Approved
DifenoxinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dihydrocodeine.Approved, Illicit
DihydroergotamineThe metabolism of Chlordiazepoxide can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dihydromorphine.Experimental, Illicit
DiltiazemThe metabolism of Chlordiazepoxide can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dimenhydrinate.Approved
DiphenhydramineThe metabolism of Chlordiazepoxide can be decreased when combined with Diphenhydramine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Diphenoxylate.Approved, Illicit
DisulfiramThe serum concentration of Chlordiazepoxide can be increased when it is combined with Disulfiram.Approved
DoramectinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Doxepin.Approved
DoxycyclineThe metabolism of Chlordiazepoxide can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved, Illicit
DronedaroneThe metabolism of Chlordiazepoxide can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Drotebanol.Experimental, Illicit
DuloxetineThe metabolism of Chlordiazepoxide can be decreased when combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dyclonine.Approved
DyphyllineThe therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Dyphylline.Approved
EcgonineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ecopipam.Investigational
EfavirenzThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Efavirenz.Approved, Investigational
EliglustatThe metabolism of Chlordiazepoxide can be decreased when combined with Eliglustat.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Chlordiazepoxide.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Enzalutamide.Approved
ErythromycinThe metabolism of Chlordiazepoxide can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstazolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Estazolam.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Chlordiazepoxide.Approved
EthanolChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Chlordiazepoxide.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Chlordiazepoxide.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etorphine.Illicit, Vet Approved
EtravirineThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Etravirine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Flibanserin.Approved
FluconazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Flunitrazepam.Approved, Illicit
FluoxetineThe metabolism of Chlordiazepoxide can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fluphenazine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Flurazepam.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fluticasone Propionate.Approved
FluvoxamineThe metabolism of Chlordiazepoxide can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Chlordiazepoxide can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Chlordiazepoxide can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Chlordiazepoxide.Approved
FospropofolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fospropofol.Approved, Illicit
Fusidic AcidThe serum concentration of Chlordiazepoxide can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Gabapentin.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Gamma Hydroxybutyric Acid.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Glutethimide.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Halazepam.Approved, Illicit, Withdrawn
HaloperidolThe metabolism of Chlordiazepoxide can be decreased when combined with Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Halothane.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Heroin.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Hexobarbital.Approved
HyaluronidaseThe therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Hyaluronidase.Approved, Investigational
HydrocodoneChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Chlordiazepoxide.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved
IdelalisibThe serum concentration of Chlordiazepoxide can be increased when it is combined with Idelalisib.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Iloperidone.Approved
ImatinibThe metabolism of Chlordiazepoxide can be decreased when combined with Imatinib.Approved
ImipramineThe metabolism of Chlordiazepoxide can be decreased when combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Chlordiazepoxide can be decreased when combined with Indinavir.Approved
IsavuconazoniumThe metabolism of Chlordiazepoxide can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Isoflurane.Approved, Vet Approved
IsoniazidThe metabolism of Chlordiazepoxide can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of Chlordiazepoxide can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Chlordiazepoxide can be increased when it is combined with Ivacaftor.Approved
KetamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ketamine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ketobemidone.Approved
KetoconazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Ketoconazole.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levobupivacaine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levomethadyl Acetate.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levorphanol.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlordiazepoxide.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lofentanil.Illicit
LopinavirThe metabolism of Chlordiazepoxide can be decreased when combined with Lopinavir.Approved
LoratadineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlordiazepoxide.Approved
LorcaserinThe metabolism of Chlordiazepoxide can be decreased when combined with Lorcaserin.Approved
LovastatinThe metabolism of Chlordiazepoxide can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Chlordiazepoxide.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lu AA21004.Investigational
LuliconazoleThe serum concentration of Chlordiazepoxide can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Chlordiazepoxide can be increased when combined with Lumacaftor.Approved
LumefantrineThe metabolism of Chlordiazepoxide can be decreased when combined with Lumefantrine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Mepivacaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Chlordiazepoxide.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Mesoridazine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Metaxalone.Approved
MethadoneChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methadyl Acetate.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Chlordiazepoxide.Approved
MethotrimeprazineChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methoxyflurane.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methylphenobarbital.Approved
MetoprololThe metabolism of Chlordiazepoxide can be decreased when combined with Metoprolol.Approved, Investigational
MetyrosineChlordiazepoxide may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Chlordiazepoxide can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved, Investigational
MirabegronThe metabolism of Chlordiazepoxide can be decreased when combined with Mirabegron.Approved
MirtazapineChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Mitotane.Approved
ModafinilThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Molindone.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Chlordiazepoxide.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved, Investigational
NafcillinThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Nafcillin.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nalbuphine.Approved
NefazodoneThe metabolism of Chlordiazepoxide can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Chlordiazepoxide can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Chlordiazepoxide can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Chlordiazepoxide can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Chlordiazepoxide can be decreased when combined with Nicardipine.Approved
NilotinibThe metabolism of Chlordiazepoxide can be decreased when combined with Nilotinib.Approved, Investigational
NitrazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nitrazepam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nitrous oxide.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Chlordiazepoxide.Approved, Investigational
OlaparibThe metabolism of Chlordiazepoxide can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Opium.Approved, Illicit
OrphenadrineChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Osanetant.Investigational
OsimertinibThe serum concentration of Chlordiazepoxide can be increased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxazepam.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxybuprocaine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxymorphone.Approved, Investigational, Vet Approved
PalbociclibThe serum concentration of Chlordiazepoxide can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Paliperidone.Approved
PanobinostatThe serum concentration of Chlordiazepoxide can be increased when it is combined with Panobinostat.Approved, Investigational
ParaldehydeChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe metabolism of Chlordiazepoxide can be decreased when combined with Paroxetine.Approved, Investigational
Peginterferon alfa-2bThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentazocineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pentazocine.Approved, Vet Approved
PentobarbitalThe metabolism of Chlordiazepoxide can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved
PerazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Perphenazine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Chlordiazepoxide.Approved
PhenobarbitalThe metabolism of Chlordiazepoxide can be increased when combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Phenoxyethanol.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Chlordiazepoxide.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pimozide.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pomalidomide.Approved
PosaconazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleChlordiazepoxide may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlordiazepoxide.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Prilocaine.Approved
PrimidoneThe metabolism of Chlordiazepoxide can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Procaine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Chlordiazepoxide.Approved, Vet Approved
PromazineThe metabolism of Chlordiazepoxide can be decreased when combined with Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Promethazine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Proparacaine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Propofol.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Quetiapine.Approved
QuinidineThe metabolism of Chlordiazepoxide can be decreased when combined with Quinidine.Approved
QuinineThe metabolism of Chlordiazepoxide can be decreased when combined with Quinine.Approved
RacloprideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ramelteon.Approved, Investigational
RanolazineThe metabolism of Chlordiazepoxide can be decreased when combined with Ranolazine.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Remifentanil.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Chlordiazepoxide.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Chlordiazepoxide.Approved
RifabutinThe metabolism of Chlordiazepoxide can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Chlordiazepoxide can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Chlordiazepoxide can be increased when combined with Rifapentine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Risperidone.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ritanserin.Investigational
RitonavirThe metabolism of Chlordiazepoxide can be decreased when combined with Ritonavir.Approved, Investigational
RolapitantThe metabolism of Chlordiazepoxide can be decreased when combined with Rolapitant.Approved
RomifidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Romifidine.Vet Approved
RopiniroleChlordiazepoxide may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Chlordiazepoxide.Approved
RotigotineChlordiazepoxide may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Chlordiazepoxide.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sage 547.Investigational
SaquinavirThe metabolism of Chlordiazepoxide can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Chlordiazepoxide.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sertindole.Approved, Withdrawn
SertralineThe metabolism of Chlordiazepoxide can be decreased when combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sevoflurane.Approved, Vet Approved
SildenafilThe metabolism of Chlordiazepoxide can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Chlordiazepoxide can be increased when it is combined with Simeprevir.Approved
Sodium oxybateChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.Approved
St. John's WortThe serum concentration of Chlordiazepoxide can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Chlordiazepoxide can be increased when it is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sufentanil.Approved, Investigational
SulfisoxazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Chlordiazepoxide.Approved
SuvorexantChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tasimelteon.Approved
TeduglutideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Teduglutide.Approved
TelaprevirThe metabolism of Chlordiazepoxide can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Chlordiazepoxide can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Chlordiazepoxide.Approved
TerbinafineThe metabolism of Chlordiazepoxide can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tetrodotoxin.Investigational
ThalidomideChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Theophylline.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Thiopental.Approved, Vet Approved
ThioridazineThe metabolism of Chlordiazepoxide can be decreased when combined with Thioridazine.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tiapride.Investigational
TiclopidineThe metabolism of Chlordiazepoxide can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tiletamine.Vet Approved
TipranavirThe metabolism of Chlordiazepoxide can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tizanidine.Approved
TocilizumabThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Tocilizumab.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Chlordiazepoxide.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe metabolism of Chlordiazepoxide can be decreased when combined with Tranylcypromine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trazodone.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Triazolam.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trifluoperazine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Triflupromazine.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Triprolidine.Approved
Uc1010The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Uc1010.Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Chlordiazepoxide.Approved, Investigational
VenlafaxineThe metabolism of Chlordiazepoxide can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Chlordiazepoxide can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Vigabatrin.Approved
VoriconazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Vortioxetine.Approved
XylazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Xylazine.Vet Approved
YohimbineThe therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Yohimbine.Approved, Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zaleplon.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Chlordiazepoxide can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zolazepam.Vet Approved
ZolpidemChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zopiclone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.
References
Synthesis Reference

Sternbach, L.H.; US. Patent 2,893,992; July 7,1959; assigned to Hoffmann-LaRoche, Inc.

General References
  1. Skerritt JH, Johnston GA: Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol. 1983 May 6;89(3-4):193-8. [PubMed:6135616 ]
  2. Oishi R, Nishibori M, Itoh Y, Saeki K: Diazepam-induced decrease in histamine turnover in mouse brain. Eur J Pharmacol. 1986 May 27;124(3):337-42. [PubMed:3089825 ]
  3. Earley JV, Fryer RI, Ning RY: Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development. J Pharm Sci. 1979 Jul;68(7):845-50. [PubMed:458601 ]
  4. Olive G, Dreux C: [Pharmacologic bases of use of benzodiazepines in pereinatal medicine]. Arch Fr Pediatr. 1977 Jan;34(1):74-89. [PubMed:851373 ]
  5. Vozeh S: [Pharmacokinetic of benzodiazepines in old age]. Schweiz Med Wochenschr. 1981 Nov 21;111(47):1789-93. [PubMed:6118950 ]
External Links
ATC CodesN05BA02
AHFS Codes
  • 28:24.08
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74.9 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9758
Caco-2 permeable+0.5868
P-glycoprotein substrateSubstrate0.6705
P-glycoprotein inhibitor INon-inhibitor0.521
P-glycoprotein inhibitor IINon-inhibitor0.7434
Renal organic cation transporterNon-inhibitor0.5502
CYP450 2C9 substrateNon-substrate0.6991
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7408
CYP450 1A2 substrateInhibitor0.7564
CYP450 2C9 inhibitorNon-inhibitor0.6038
CYP450 2D6 inhibitorNon-inhibitor0.7862
CYP450 2C19 inhibitorNon-inhibitor0.5
CYP450 3A4 inhibitorInhibitor0.7067
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.6372
Ames testNon AMES toxic0.593
CarcinogenicityNon-carcinogens0.7108
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.8520 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9198
hERG inhibition (predictor II)Non-inhibitor0.8828
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Valeant pharmaceuticals international
  • Abbott laboratories pharmaceutical products div
  • Rachelle laboratories inc
  • Ascot hosp pharmaceuticals inc div travenol laboratories inc
  • Barr laboratories inc
  • John j ferrante
  • Halsey drug co inc
  • Impax laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lederle laboratories div american cyanamid co
  • Mm mast and co
  • Mylan pharmaceuticals inc
  • Parke davis div warner lambert co
  • Pioneer pharmaceuticals inc
  • Purepac pharmaceutical co
  • Roxane laboratories inc
  • Sandoz inc
  • Superpharm corp
  • Teva pharmaceuticals usa inc
  • Usl pharma inc
  • Vangard laboratories inc div midway medical co
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Alra laboratories inc
Packagers
Dosage forms
FormRouteStrength
CapsuleOral10 mg
CapsuleOral25 mg
CapsuleOral5 mg
TabletOral
Tablet, film coatedOral
CapsuleOral10 mg/1
CapsuleOral25 mg/1
CapsuleOral5 mg/1
Capsule, gelatin coatedOral10 mg/1
Capsule, gelatin coatedOral25 mg/1
Capsule, gelatin coatedOral5 mg/1
CapsuleOral
Prices
Unit descriptionCostUnit
Librax 2.5-5 mg capsule6.5USD capsule
Librax capsule5.78USD capsule
Librium 25 mg capsule2.14USD capsule
Limbitrol DS 10-25 mg tablet1.93USD tablet
Librium 10 mg capsule1.61USD capsule
Librium 5 mg capsule0.84USD capsule
Chlordiazepoxide 25 mg capsule0.72USD capsule
ChlordiazePOXIDE HCl 25 mg capsule0.32USD capsule
ChlordiazePOXIDE HCl 10 mg capsule0.31USD capsule
ChlordiazePOXIDE HCl 5 mg capsule0.31USD capsule
Chlordiazepoxide 5 mg capsule0.2USD capsule
Apo-Chlordiazepoxide 25 mg Capsule0.17USD capsule
Chlordiazepoxide 10 mg capsule0.14USD capsule
Apo-Chlordiazepoxide 10 mg Capsule0.11USD capsule
Apo-Chlordiazepoxide 5 mg Capsule0.07USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point236-236.5Sternbach, L.H.; US. Patent 2,893,992; July 7,1959; assigned to Hoffmann-LaRoche, Inc.
water solubility2000 mg/LYALKOWSKY,SH & DANNENFELSER,RM (1992)
logP2.44HANSCH,C ET AL. (1995)
pKa4.8MERCK INDEX (1996)
Predicted Properties
PropertyValueSource
Water Solubility0.0199 mg/mLALOGPS
logP2.01ALOGPS
logP3.05ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)18.52ChemAxon
pKa (Strongest Basic)6.43ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area53.14 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity87.34 m3·mol-1ChemAxon
Polarizability30.97 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzodiazepines
Sub Class1,4-benzodiazepines
Direct Parent1,4-benzodiazepines
Alternative Parents
Substituents
  • 1,4-benzodiazepine
  • Imidolactam
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Nitrone
  • Azacycle
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Allyl-type 1,3-dipolar organic compound
  • Carboxylic acid amidine
  • Amidine
  • Hydrocarbon derivative
  • Organic salt
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Organic cation
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
positive allosteric modulator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Components:
NameUniProt IDDetails
Gamma-aminobutyric acid receptor subunit alpha-1P14867 Details
Gamma-aminobutyric acid receptor subunit alpha-2P47869 Details
Gamma-aminobutyric acid receptor subunit alpha-3P34903 Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169 Details
Gamma-aminobutyric acid receptor subunit alpha-5P31644 Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445 Details
Gamma-aminobutyric acid receptor subunit beta-1P18505 Details
Gamma-aminobutyric acid receptor subunit beta-2P47870 Details
Gamma-aminobutyric acid receptor subunit beta-3P28472 Details
Gamma-aminobutyric acid receptor subunit deltaO14764 Details
Gamma-aminobutyric acid receptor subunit epsilonP78334 Details
Gamma-aminobutyric acid receptor subunit gamma-1Q8N1C3 Details
Gamma-aminobutyric acid receptor subunit gamma-2P18507 Details
Gamma-aminobutyric acid receptor subunit gamma-3Q99928 Details
Gamma-aminobutyric acid receptor subunit piO00591 Details
Gamma-aminobutyric acid receptor subunit thetaQ9UN88 Details
References
  1. Skerritt JH, Johnston GA: Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol. 1983 May 6;89(3-4):193-8. [PubMed:6135616 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23