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Identification
NameNitrazepam
Accession NumberDB01595
TypeSmall Molecule
GroupsApproved
DescriptionA benzodiazepine derivative used as an anticonvulsant and hypnotic.
Structure
Thumb
Synonyms
1,3-dihydro-7-Nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
2,3-dihydro-7-Nitro-5-phenyl-1H-1,4-benzodiazepin-2-one
7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Apodorm
Atempol
Benzalin
Calsmin
Eatan
Eunoctin
Gerson
Hipnax
Hipsal
Ibrovek
Imeson
Imesont
Mogadon
N-Desmethylnimetazepam
Nelbon
Nelmat
Neozepam
Neuchlonic
Nitrados
Nitrazepamum
Paxisyn
Pelson
Persopit
Radedorm
Relact
Remnos
Ro 4-5360
Ro 5-3059
Somitran
Sonebon
Sonnolin
Surem
Trazenin
Unisomnia
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
MogadonTablet5 mgOralAa Pharma Inc1980-12-31Not applicableCanada
MogadonTablet10 mgOralAa Pharma Inc1980-12-31Not applicableCanada
NitrazadonTablet5 mgOralAa Pharma Inc1996-11-082014-06-25Canada
NitrazadonTablet10 mgOralAa Pharma Inc1996-11-082014-06-25Canada
Nitrazepam-10Tablet10 mgOralPro Doc Limitee2004-07-292010-07-13Canada
Nitrazepam-5Tablet5 mgOralPro Doc Limitee2004-07-292010-07-13Canada
Sandoz NitrazepamTablet5 mgOralSandoz Canada Incorporated1997-12-02Not applicableCanada
Sandoz NitrazepamTablet10 mgOralSandoz Canada Incorporated1997-12-02Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-nitrazepam Tablets BPTablet5 mgOralApotex Inc2002-09-17Not applicableCanada
Apo-nitrazepam Tablets BPTablet10 mgOralApotex Inc2002-09-17Not applicableCanada
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AlodormNot Available
AremNot Available
BenzalinNot Available
InsomaNot Available
NitradosNot Available
NitrosunNot Available
OrmodonNot Available
PacisynNot Available
PaxadormNot Available
RemnosNot Available
SomniteNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII9CLV70W7HS
CAS number146-22-5
WeightAverage: 281.2661
Monoisotopic: 281.080041233
Chemical FormulaC15H11N3O3
InChI KeyKJONHKAYOJNZEC-UHFFFAOYSA-N
InChI
InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)
IUPAC Name
7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
SMILES
[O-][N+](=O)C1=CC2=C(NC(=O)CN=C2C2=CC=CC=C2)C=C1
Pharmacology
IndicationUsed to treat short-term sleeping problems (insomnia), such as difficulty falling asleep, frequent awakenings during the night, and early-morning awakening.
Structured Indications
PharmacodynamicsNitrazepam is a type of benzodiazepine drug. It is a powerful hypnotic drug which possesses strong sedative, anxiolytic, amnestic, anticonvulsant, and skeletal muscle relaxant properties. Nitrazepam shortens the time required to fall asleep and lengthens the duration of sleep. It is also useful for the management of myoclonic seizures.
Mechanism of actionNitrazepam belongs to a group of medicines called benzodiazepines. It acts on benzodiazepine receptors in the brain which are associated with the GABA receptors causing an enhanced binding of GABA (gamma amino butyric acid) to GABAA receptors. GABA is a major inhibitory neurotransmitter in the brain, involved in inducing sleepiness, muscular relaxation and control of anxiety and fits, and slows down the central nervous system. The anticonvulsant properties of nitrazepam and other benzodiazepines may be in part or entirely due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. Sustained repetitive firing seems to be limited by benzodiazepines effect of slowing recovery of sodium channels from inactivation.
TargetKindPharmacological actionActionsOrganismUniProt ID
Gamma-aminobutyric acid receptor subunit alpha-1Proteinyes
potentiator
HumanP14867 details
Gamma-aminobutyric acid receptor subunit alpha-2Proteinyes
potentiator
HumanP47869 details
Gamma-aminobutyric acid receptor subunit alpha-3Proteinyes
potentiator
HumanP34903 details
Gamma-aminobutyric acid receptor subunit alpha-4Proteinyes
potentiator
HumanP48169 details
Gamma-aminobutyric acid receptor subunit alpha-5Proteinyes
potentiator
HumanP31644 details
Gamma-aminobutyric acid receptor subunit alpha-6Proteinyes
potentiator
HumanQ16445 details
Gamma-aminobutyric acid receptor subunit beta-1Proteinyes
potentiator
HumanP18505 details
Gamma-aminobutyric acid receptor subunit beta-2Proteinyes
potentiator
HumanP47870 details
Gamma-aminobutyric acid receptor subunit beta-3Proteinyes
potentiator
HumanP28472 details
Gamma-aminobutyric acid receptor subunit gamma-1Proteinyes
potentiator
HumanQ8N1C3 details
Gamma-aminobutyric acid receptor subunit gamma-2Proteinyes
potentiator
HumanP18507 details
Gamma-aminobutyric acid receptor subunit gamma-3Proteinyes
potentiator
HumanQ99928 details
Gamma-aminobutyric acid receptor subunit deltaProteinyes
potentiator
HumanO14764 details
Gamma-aminobutyric acid receptor subunit epsilonProteinyes
potentiator
HumanP78334 details
Gamma-aminobutyric acid receptor subunit piProteinyes
potentiator
HumanO00591 details
Gamma-aminobutyric acid receptor subunit rho-1Proteinyes
potentiator
HumanP24046 details
Gamma-aminobutyric acid receptor subunit rho-2Proteinyes
potentiator
HumanP28476 details
Gamma-aminobutyric acid receptor subunit rho-3Proteinyes
potentiator
HumanA8MPY1 details
Gamma-aminobutyric acid receptor subunit thetaProteinyes
potentiator
HumanQ9UN88 details
Sodium channel protein type 1 subunit alphaProteinunknown
other/unknown
HumanP35498 details
Related Articles
AbsorptionBioavailability is 53-94% following oral administration.
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half life15-38 hours (mean elimination half life 26 hours).
ClearanceNot Available
ToxicityNitrazepam is a drug which is very frequently involved in drug intoxication, including overdose. Nitrazepam overdose may result in stereotypical symptoms of benzodiazepine overdose including intoxication, impaired balance, slurred speech. In cases of severe overdose this may progress to a comatose state with the possibility of death.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with 1,1,1,2 Tetrafluoroethane.Investigational
7-NitroindazoleThe risk or severity of adverse effects can be increased when Nitrazepam is combined with 7-Nitroindazole.Experimental
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Nitrazepam.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Aceprometazine.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Nitrazepam.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Nitrazepam.Approved, Vet Approved
adipiplonThe risk or severity of adverse effects can be increased when Nitrazepam is combined with adipiplon.Investigational
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Nitrazepam.Approved
AgomelatineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Agomelatine.Approved, Investigational
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Nitrazepam.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Nitrazepam.Approved, Illicit
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Nitrazepam.Approved, Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Nitrazepam.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Nitrazepam.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Nitrazepam.Approved, Investigational
Ambroxol acefyllinateThe therapeutic efficacy of Nitrazepam can be decreased when used in combination with Ambroxol acefyllinate.Experimental
AminophyllineThe therapeutic efficacy of Nitrazepam can be decreased when used in combination with Aminophylline.Approved
AmiodaroneThe metabolism of Nitrazepam can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Amisulpride.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Nitrazepam.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Nitrazepam.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Amperozide.Experimental
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Nitrazepam.Approved
AprepitantThe serum concentration of Nitrazepam can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Nitrazepam.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Nitrazepam.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Asenapine.Approved
AtazanavirThe metabolism of Nitrazepam can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Nitrazepam.Approved
AtomoxetineThe metabolism of Nitrazepam can be decreased when combined with Atomoxetine.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Nitrazepam.Approved, Investigational
AzaperoneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Azaperone.Vet Approved
AzelastineNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Nitrazepam.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Nitrazepam.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Benzyl alcohol.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Nitrazepam.Approved, Vet Approved
BexaroteneThe serum concentration of Nitrazepam can be decreased when it is combined with Bexarotene.Approved, Investigational
BoceprevirThe metabolism of Nitrazepam can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Nitrazepam can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Nitrazepam can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Nitrazepam.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Nitrazepam.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Nitrazepam.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Nitrazepam.Approved, Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Brotizolam.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nitrazepam.Approved, Investigational
BuprenorphineNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Nitrazepam.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Nitrazepam.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Nitrazepam.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Nitrazepam.Approved, Illicit, Vet Approved
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Nitrazepam.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Nitrazepam.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Nitrazepam.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Nitrazepam.Approved
CarbamazepineThe metabolism of Nitrazepam can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nitrazepam.Illicit, Vet Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Nitrazepam.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Carisoprodol.Approved
CeritinibThe serum concentration of Nitrazepam can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Nitrazepam.Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nitrazepam.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nitrazepam.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Nitrazepam.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Nitrazepam.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Chlorphenamine.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Nitrazepam.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Nitrazepam.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Chlorzoxazone.Approved
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Nitrazepam.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Nitrazepam.Approved, Vet Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Nitrazepam.Approved, Investigational
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Nitrazepam.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Nitrazepam.Approved
ClarithromycinThe metabolism of Nitrazepam can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Nitrazepam can be decreased when combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Clidinium.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Nitrazepam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Nitrazepam is combined with clomethiazole.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Nitrazepam.Approved, Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Clonazepam.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Nitrazepam.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Nitrazepam.Approved, Nutraceutical
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Nitrazepam.Approved, Illicit
ClotrimazoleThe metabolism of Nitrazepam can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Clozapine.Approved
CobicistatThe metabolism of Nitrazepam can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Nitrazepam.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Nitrazepam.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Nitrazepam.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Nitrazepam.Approved
ConivaptanThe serum concentration of Nitrazepam can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Nitrazepam.Approved
CosyntropinCosyntropin may increase the hepatotoxic activities of Nitrazepam.Approved
CrizotinibThe metabolism of Nitrazepam can be decreased when combined with Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Nitrazepam.Approved
CyclosporineThe metabolism of Nitrazepam can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Cyproheptadine.Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Nitrazepam.Approved
DabrafenibThe serum concentration of Nitrazepam can be decreased when it is combined with Dabrafenib.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Nitrazepam.Approved
DantroleneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Dantrolene.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Nitrazepam.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Nitrazepam.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Dapoxetine.Investigational
DarunavirThe metabolism of Nitrazepam can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Nitrazepam can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Nitrazepam.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Nitrazepam.Approved
DeferasiroxThe serum concentration of Nitrazepam can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Nitrazepam can be decreased when combined with Delavirdine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Nitrazepam.Approved
DesipramineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Detomidine.Vet Approved
DexamethasoneThe serum concentration of Nitrazepam can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Nitrazepam.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Nitrazepam.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Nitrazepam.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Nitrazepam.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Nitrazepam.Approved, Illicit, Vet Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Nitrazepam.Approved
DifenoxinThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Difenoxin.Approved, Illicit
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Nitrazepam.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Nitrazepam.Approved
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Nitrazepam.Approved, Illicit
DihydroergotamineThe metabolism of Nitrazepam can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Nitrazepam.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Nitrazepam.Experimental, Illicit
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Nitrazepam.Illicit
DiltiazemThe metabolism of Nitrazepam can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Nitrazepam.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Nitrazepam.Approved, Illicit
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Nitrazepam.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Nitrazepam.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Nitrazepam.Approved, Investigational, Vet Approved
DoramectinThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Nitrazepam.Approved, Investigational
DoxycyclineThe metabolism of Nitrazepam can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Nitrazepam is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved, Illicit
DronedaroneThe metabolism of Nitrazepam can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Nitrazepam.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Nitrazepam.Approved
DyphyllineThe therapeutic efficacy of Nitrazepam can be decreased when used in combination with Dyphylline.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Nitrazepam.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Nitrazepam is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Ecopipam.Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Nitrazepam.Approved
EfavirenzThe serum concentration of Nitrazepam can be decreased when it is combined with Efavirenz.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Nitrazepam.Approved, Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Nitrazepam.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of Nitrazepam can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Nitrazepam.Approved, Investigational
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Nitrazepam.Approved, Investigational
ErythromycinThe metabolism of Nitrazepam can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Nitrazepam can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Nitrazepam.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Nitrazepam.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Nitrazepam.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Nitrazepam.Approved
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Nitrazepam.Approved
EthanolNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Nitrazepam.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Nitrazepam.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Nitrazepam.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Nitrazepam.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Nitrazepam.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Etoperidone.Approved
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Nitrazepam.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Nitrazepam.Illicit, Vet Approved
EtravirineThe serum concentration of Nitrazepam can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Nitrazepam.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Nitrazepam.Approved
EzogabineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Nitrazepam.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Nitrazepam.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Nitrazepam.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Nitrazepam.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Nitrazepam.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Flibanserin.Approved
FluconazoleThe metabolism of Nitrazepam can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Nitrazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Nitrazepam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Nitrazepam.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Nitrazepam.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Nitrazepam.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Fluspirilene.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Nitrazepam.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Fluticasone Propionate.Approved
FluvoxamineThe metabolism of Nitrazepam can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Nitrazepam can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Nitrazepam can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Nitrazepam.Approved
FospropofolThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Fospropofol.Approved, Illicit
Fusidic AcidThe serum concentration of Nitrazepam can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Nitrazepam.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Nitrazepam is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Nitrazepam.Approved, Illicit
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Nitrazepam.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Nitrazepam.Approved
GepironeThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nitrazepam.Approved, Illicit
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Nitrazepam.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Nitrazepam.Withdrawn
GuanfacineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Nitrazepam.Approved, Illicit, Withdrawn
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Nitrazepam.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Nitrazepam.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Nitrazepam.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Nitrazepam.Approved
HyaluronidaseThe therapeutic efficacy of Nitrazepam can be decreased when used in combination with Hyaluronidase.Approved, Investigational
HydrocodoneNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Nitrazepam.Approved, Vet Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Nitrazepam.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Nitrazepam.Approved
IdelalisibThe serum concentration of Nitrazepam can be increased when it is combined with Idelalisib.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Iloperidone.Approved
ImatinibThe metabolism of Nitrazepam can be decreased when combined with Imatinib.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Nitrazepam.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Nitrazepam.Approved
IndalpineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Nitrazepam can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Nitrazepam.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Nitrazepam.Approved, Investigational
IsavuconazoniumThe metabolism of Nitrazepam can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Nitrazepam.Approved, Vet Approved
IsradipineThe metabolism of Nitrazepam can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Nitrazepam can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Nitrazepam can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Nitrazepam.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Nitrazepam.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Nitrazepam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Ketobemidone.Approved
KetoconazoleThe metabolism of Nitrazepam can be decreased when combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Nitrazepam.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Nitrazepam.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Nitrazepam.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Nitrazepam.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Nitrazepam.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Nitrazepam.Approved
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Nitrazepam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Nitrazepam.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Levodopa.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Nitrazepam.Approved, Investigational
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Nitrazepam.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Nitrazepam.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Nitrazepam.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Nitrazepam.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Nitrazepam.Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Nitrazepam.Approved
LofentanilThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Lofentanil.Illicit
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Nitrazepam.Approved
LopinavirThe metabolism of Nitrazepam can be decreased when combined with Lopinavir.Approved
LoratadineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nitrazepam.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Nitrazepam.Approved
LovastatinThe metabolism of Nitrazepam can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Nitrazepam.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Nitrazepam is combined with Lu AA21004.Investigational
LuliconazoleThe serum concentration of Nitrazepam can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Nitrazepam can be increased when combined with Lumacaftor.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved, Vet Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Nitrazepam.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Medetomidine.Vet Approved
MefloquineThe therapeutic efficacy of Nitrazepam can be decreased when used in combination with Mefloquine.Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Nitrazepam.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Nitrazepam.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Nitrazepam.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Nitrazepam.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Metaxalone.Approved
MethadoneNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Nitrazepam.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Nitrazepam.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Nitrazepam.Approved
MethotrimeprazineNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Nitrazepam.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Nitrazepam.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Nitrazepam.Approved, Vet Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Nitrazepam.Approved, Investigational
MetyrosineNitrazepam may increase the sedative activities of Metyrosine.Approved
MianserinThe therapeutic efficacy of Nitrazepam can be decreased when used in combination with Mianserin.Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Nitrazepam.Approved, Illicit
MifepristoneThe serum concentration of Nitrazepam can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Nitrazepam.Approved
MirtazapineNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Nitrazepam can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Nitrazepam.Approved, Investigational
ModafinilThe serum concentration of Nitrazepam can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Molindone.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Nitrazepam.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Nitrazepam.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Nitrazepam.Approved
NafcillinThe serum concentration of Nitrazepam can be decreased when it is combined with Nafcillin.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Nitrazepam.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Nitrazepam.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Nitrazepam.Approved, Vet Approved
NefazodoneThe metabolism of Nitrazepam can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Nitrazepam can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Nitrazepam can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Nitrazepam can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Nitrazepam.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Nitrazepam.Approved
NilotinibThe metabolism of Nitrazepam can be decreased when combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Nitrazepam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Nitrous oxide.Approved, Vet Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Nitrazepam.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Nitrazepam.Approved, Investigational
OlaparibThe metabolism of Nitrazepam can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Olopatadine.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Nitrazepam.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Nitrazepam.Approved
OpiumThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Opium.Approved, Illicit
OrlistatThe serum concentration of Nitrazepam can be decreased when it is combined with Orlistat.Approved, Investigational
OrphenadrineNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Osanetant.Investigational
OsimertinibThe serum concentration of Nitrazepam can be increased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Nitrazepam.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Nitrazepam.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Nitrazepam.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Nitrazepam.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Nitrazepam.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Nitrazepam.Approved, Vet Approved
PalbociclibThe serum concentration of Nitrazepam can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Nitrazepam.Approved
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Nitrazepam.Approved, Investigational
ParaldehydeNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Nitrazepam.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Nitrazepam.Approved, Vet Approved
PentobarbitalThe metabolism of Nitrazepam can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved
PerazineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Nitrazepam.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Nitrazepam.Approved
PhenobarbitalThe metabolism of Nitrazepam can be increased when combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Phenoxyethanol.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Nitrazepam.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Nitrazepam.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Piritramide.Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Nitrazepam.Approved
PizotifenThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Pizotifen.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Nitrazepam.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Nitrazepam.Approved
PosaconazoleThe metabolism of Nitrazepam can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleNitrazepam may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Pramocaine.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Nitrazepam.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Nitrazepam.Approved, Illicit
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Nitrazepam.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Nitrazepam.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Nitrazepam.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nitrazepam.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Nitrazepam.Approved
PrimidoneThe metabolism of Nitrazepam can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Nitrazepam.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Nitrazepam.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Nitrazepam.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Nitrazepam.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Promethazine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Nitrazepam.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Nitrazepam.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Propoxycaine.Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Nitrazepam.Approved, Investigational
ProtriptylineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Nitrazepam.Approved
PSD502The risk or severity of adverse effects can be increased when Nitrazepam is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Nitrazepam.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Nitrazepam.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Nitrazepam.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Nitrazepam.Approved
RacloprideThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Ramelteon.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Nitrazepam.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Nitrazepam.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Nitrazepam.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Nitrazepam.Approved, Withdrawn
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Nitrazepam.Approved
RifabutinThe metabolism of Nitrazepam can be increased when combined with Rifabutin.Approved
RifampicinThe serum concentration of Nitrazepam can be decreased when it is combined with Rifampicin.Approved
RifapentineThe metabolism of Nitrazepam can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Nitrazepam.Approved, Investigational
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Nitrazepam.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Ritanserin.Investigational
RitonavirThe metabolism of Nitrazepam can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Nitrazepam.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Nitrazepam.Approved, Investigational
RomifidineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Romifidine.Vet Approved
RopiniroleNitrazepam may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Nitrazepam.Approved
RotigotineNitrazepam may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Nitrazepam.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Nitrazepam is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Nitrazepam is combined with Sage 547.Investigational
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Nitrazepam.Approved, Vet Approved
SaquinavirThe metabolism of Nitrazepam can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Nitrazepam.Approved, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Nitrazepam.Approved
SertindoleThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Sertindole.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Nitrazepam.Approved, Vet Approved
SildenafilThe metabolism of Nitrazepam can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Nitrazepam.Approved
SiltuximabThe serum concentration of Nitrazepam can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Nitrazepam can be increased when it is combined with Simeprevir.Approved
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Nitrazepam.Approved, Investigational
Sodium oxybateNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Nitrazepam.Approved
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Nitrazepam.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Nitrazepam.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Nitrazepam.Experimental
St. John's WortThe serum concentration of Nitrazepam can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Nitrazepam can be increased when it is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Nitrazepam.Approved, Investigational
SulfisoxazoleThe metabolism of Nitrazepam can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Nitrazepam.Approved
SuvorexantNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Nitrazepam.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Nitrazepam.Approved
TandospironeThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Tasimelteon.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Nitrazepam.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Nitrazepam.Approved
TeduglutideThe serum concentration of Nitrazepam can be increased when it is combined with Teduglutide.Approved
TelaprevirThe metabolism of Nitrazepam can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Nitrazepam can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Nitrazepam.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Nitrazepam.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Tetrodotoxin.Investigational
ThalidomideNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe therapeutic efficacy of Nitrazepam can be decreased when used in combination with Theophylline.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Nitrazepam.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Nitrazepam.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Nitrazepam.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Tiapride.Investigational
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Nitrazepam.Approved
TiclopidineThe metabolism of Nitrazepam can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Tiletamine.Vet Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Nitrazepam.Approved
TizanidineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Tizanidine.Approved
TocilizumabThe serum concentration of Nitrazepam can be decreased when it is combined with Tocilizumab.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Tolcapone.Approved, Withdrawn
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Nitrazepam.Approved
TopiramateThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Topiramate.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Nitrazepam.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Nitrazepam.Approved, Investigational
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Nitrazepam.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Nitrazepam.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Nitrazepam.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Nitrazepam.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Nitrazepam.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Nitrazepam.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Nitrazepam.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Triprolidine.Approved
Uc1010The risk or severity of adverse effects can be increased when Nitrazepam is combined with Uc1010.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Nitrazepam.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Nitrazepam.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Nitrazepam.Approved, Investigational
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Nitrazepam.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Nitrazepam.Approved
VenlafaxineThe metabolism of Nitrazepam can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Nitrazepam can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Vigabatrin.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Nitrazepam.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Nitrazepam.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Nitrazepam.Approved
VoriconazoleThe metabolism of Nitrazepam can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Vortioxetine.Approved
XylazineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Xylazine.Vet Approved
YohimbineThe therapeutic efficacy of Nitrazepam can be decreased when used in combination with Yohimbine.Approved, Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Nitrazepam.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Ziconotide.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Nitrazepam.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Nitrazepam can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Zolazepam.Vet Approved
ZolpidemNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Nitrazepam.Approved
ZotepineThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Take with food.
References
Synthesis ReferenceNot Available
General References
  1. Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. [PubMed:2883820 ]
  2. Robertson MD, Drummer OH: Postmortem drug metabolism by bacteria. J Forensic Sci. 1995 May;40(3):382-6. [PubMed:7782744 ]
  3. Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines]. Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. [PubMed:2570451 ]
  4. Podhorna J, Krsiak M: Behavioural effects of a benzodiazepine receptor partial agonist, Ro 19-8022, in the social conflict test in mice. Behav Pharmacol. 2000 Apr;11(2):143-51. [PubMed:10877119 ]
  5. Nowakowska E, Chodera A: Studies on the involvement of opioid mechanism in the locomotor effects of benzodiazepines in rats. Pharmacol Biochem Behav. 1991 Feb;38(2):265-6. [PubMed:1676167 ]
External Links
ATC CodesN05CD02
AHFS Codes
  • 28:24.08
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9925
Blood Brain Barrier+0.9802
Caco-2 permeable+0.5176
P-glycoprotein substrateSubstrate0.5785
P-glycoprotein inhibitor INon-inhibitor0.8782
P-glycoprotein inhibitor IINon-inhibitor0.9205
Renal organic cation transporterNon-inhibitor0.8307
CYP450 2C9 substrateNon-substrate0.7695
CYP450 2D6 substrateNon-substrate0.8583
CYP450 3A4 substrateSubstrate0.6725
CYP450 1A2 substrateInhibitor0.7569
CYP450 2C9 inhibitorNon-inhibitor0.6133
CYP450 2D6 inhibitorNon-inhibitor0.8986
CYP450 2C19 inhibitorInhibitor0.5682
CYP450 3A4 inhibitorInhibitor0.6791
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5645
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.7197
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.5397 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9904
hERG inhibition (predictor II)Non-inhibitor0.8498
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
TabletOral10 mg
TabletOral5 mg
Prices
Unit descriptionCostUnit
Mogadon 10 mg Tablet0.24USD tablet
Mogadon 5 mg Tablet0.16USD tablet
Apo-Nitrazepam 10 mg Tablet0.13USD tablet
Nitrazadon 10 mg Tablet0.11USD tablet
Sandoz Nitrazepam 10 mg Tablet0.11USD tablet
Apo-Nitrazepam 5 mg Tablet0.09USD tablet
Nitrazadon 5 mg Tablet0.08USD tablet
Sandoz Nitrazepam 5 mg Tablet0.08USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point225 °CPhysProp
logP2.25HANSCH,C ET AL. (1995)
logS-3.8ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.0299 mg/mLALOGPS
logP1.95ALOGPS
logP2.55ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)11.9ChemAxon
pKa (Strongest Basic)2.61ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area87.28 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity79.22 m3·mol-1ChemAxon
Polarizability27.59 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0zgi-2490000000-84b5bf7df62c745f8414View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzodiazepines
Sub Class1,4-benzodiazepines
Direct Parent1,4-benzodiazepines
Alternative Parents
Substituents
  • 1,4-benzodiazepine
  • Benzenoid
  • Monocyclic benzene moiety
  • Organic nitro compound
  • Secondary carboxylic acid amide
  • Organic nitrite
  • C-nitro compound
  • Lactam
  • Ketimine
  • Carboxamide group
  • Azacycle
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Allyl-type 1,3-dipolar organic compound
  • Organic oxoazanium
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organic salt
  • Organooxygen compound
  • Organonitrogen compound
  • Imine
  • Carbonyl group
  • Organic zwitterion
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By si...
Gene Name:
GABRA1
Uniprot ID:
P14867
Molecular Weight:
51801.395 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
  3. Podhorna J, Krsiak M: Behavioural effects of a benzodiazepine receptor partial agonist, Ro 19-8022, in the social conflict test in mice. Behav Pharmacol. 2000 Apr;11(2):143-51. [PubMed:10877119 ]
  4. Tanaka M, Suemaru K, Watanabe S, Cui R, Li B, Araki H: Comparison of short- and long-acting benzodiazepine-receptor agonists with different receptor selectivity on motor coordination and muscle relaxation following thiopental-induced anesthesia in mice. J Pharmacol Sci. 2008 Jul;107(3):277-84. Epub 2008 Jul 5. [PubMed:18603831 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRA2
Uniprot ID:
P47869
Molecular Weight:
51325.85 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRA3
Uniprot ID:
P34903
Molecular Weight:
55164.055 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRA4
Uniprot ID:
P48169
Molecular Weight:
61622.645 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Transporter activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRA5
Uniprot ID:
P31644
Molecular Weight:
52145.645 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRA6
Uniprot ID:
Q16445
Molecular Weight:
51023.69 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By si...
Gene Name:
GABRB1
Uniprot ID:
P18505
Molecular Weight:
54234.085 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Gene Name:
GABRB2
Uniprot ID:
P47870
Molecular Weight:
59149.895 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Gaba-gated chloride ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Gene Name:
GABRB3
Uniprot ID:
P28472
Molecular Weight:
54115.04 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRG1
Uniprot ID:
Q8N1C3
Molecular Weight:
53594.49 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Gene Name:
GABRG2
Uniprot ID:
P18507
Molecular Weight:
54161.78 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRG3
Uniprot ID:
Q99928
Molecular Weight:
54288.16 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Gaba-a receptor activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRD
Uniprot ID:
O14764
Molecular Weight:
50707.835 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRE
Uniprot ID:
P78334
Molecular Weight:
57971.175 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Gaba-a receptor activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to ...
Gene Name:
GABRP
Uniprot ID:
O00591
Molecular Weight:
50639.735 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Gaba-a receptor activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
Gene Name:
GABRR1
Uniprot ID:
P24046
Molecular Weight:
55882.91 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Gaba-a receptor activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission.
Gene Name:
GABRR2
Uniprot ID:
P28476
Molecular Weight:
54150.41 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Gaba-a receptor activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRR3
Uniprot ID:
A8MPY1
Molecular Weight:
54271.1 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Transmembrane signaling receptor activity
Specific Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name:
GABRQ
Uniprot ID:
Q9UN88
Molecular Weight:
72020.875 Da
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Voltage-gated sodium channel activity
Specific Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Gene Name:
SCN1A
Uniprot ID:
P35498
Molecular Weight:
228969.49 Da
References
  1. McLean MJ, Macdonald RL: Benzodiazepines, but not beta carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture. J Pharmacol Exp Ther. 1988 Feb;244(2):789-95. [PubMed:2450203 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Tassaneeyakul W, Birkett DJ, Miners JO: Inhibition of human hepatic cytochrome P4502E1 by azole antifungals, CNS-active drugs and non-steroidal anti-inflammatory agents. Xenobiotica. 1998 Mar;28(3):293-301. [PubMed:9574817 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. [PubMed:12438524 ]
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Drug created on August 29, 2007 11:49 / Updated on August 17, 2016 12:23