Oral Lichen Planus

Also known as: Lichen Planus, Oral

DrugDrug NameDrug Description
DB00864TacrolimusTacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
DrugDrug NamePhaseStatusCount
DB01234Dexamethasone0Recruiting1
DB00443Betamethasone2Completed1
DB00443Betamethasone2Recruiting1
DB11750Clobetasol2Completed1
DB01013Clobetasol propionate2Recruiting2
DB11672Curcumin2Completed1
DB01234Dexamethasone2Completed1
DB10675Licorice2Completed1
DB11133Omega-3 fatty acids2Completed1
DB00337Pimecrolimus2Completed1
DB00635Prednisone2Completed1
DB00864Tacrolimus2Completed1
DB00620Triamcinolone2Completed1
DB00443Betamethasone3Terminated1
DB01234Dexamethasone3Unknown Status1
DB01017Minocycline3Unknown Status1
DB00877Sirolimus3Terminated1
DB00620Triamcinolone3Completed1
DB01296Glucosamine4Completed1
DB11231Lycopene4Completed1
DB00337Pimecrolimus4Completed1
DB00860Prednisolone4Completed1
DB00620Triamcinolone4Completed1
DB11059CarboxymethylcelluloseNot AvailableTerminated1
DB12553FluocinoloneNot AvailableCompleted1
DB11242GelatinNot AvailableTerminated1
DB00646NystatinNot AvailableCompleted1
DB11158PectinNot AvailableTerminated1
DB00864TacrolimusNot AvailableTerminated1
DB00620TriamcinoloneNot AvailableTerminated1