Also known as: Allergy / Hypersensitivity NOS / Hypersensitivity reaction / Allergy NOS / Hypersensitivity reaction (NOS) / Reaction hypersensitivity (NOS) / Allergic reaction / Hypersensitivity / Allergic reaction NOS / Reaction allergic (NOS) / Allergic reaction (NOS) / HYSN / Hypersensitivity symptom

DrugDrug NameDrug Description
DB00835BrompheniramineHistamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. [PubChem]
DB01222BudesonideBudesonide is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. [PubChem] The extended release oral tablet, marketed as Uceris, was FDA approved on January 14, 2013 for the management of ulcerative colitis. Budesonide is provided as a mixture of two epimers (22R and 22S). Interestingly, the 22R form is two times more active than the 22S epimer. The two forms do not interconvert.
DB08936ChlorcyclizineChlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used as an antiemetic.
DB01114ChlorphenamineA histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]
DB09555Dexchlorpheniramine maleateDexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.
DB01075DiphenhydramineA histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
DB00062Human Serum AlbuminHuman serum albumin isolated from expired blood plasma. In the iodonated form ( I 131), it is used as a diagnostic radiopharmaceutical for intravenous imaging.
DB00557HydroxyzineA histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. [PubChem]
DB06691MepyramineMepyramine (also known as pyrilamine) is a first generation antihistamine, targeting the H1 receptor. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It is used in over-the-counter combination products for colds and menstrual symptoms.
DB00427TriprolidineFirst generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
DrugDrug NameTargetType
DB00835BrompheniramineHistamine H1 receptortarget
DB00835BrompheniramineMuscarinic acetylcholine receptor M1target
DB00835BrompheniramineMuscarinic acetylcholine receptor M2target
DB00835BrompheniramineMuscarinic acetylcholine receptor M3target
DB00835BrompheniramineMuscarinic acetylcholine receptor M4target
DB00835BrompheniramineMuscarinic acetylcholine receptor M5target
DB00835BrompheniramineCytochrome P450 2B6enzyme
DB00835BrompheniramineCytochrome P450 2C19enzyme
DB00835BrompheniramineCytochrome P450 2C8enzyme
DB00835BrompheniramineCytochrome P450 2C9enzyme
DB00835BrompheniramineCytochrome P450 2D6enzyme
DB00835BrompheniramineCytochrome P450 2E1enzyme
DB00835BrompheniramineCytochrome P450 3A4enzyme
DB01222BudesonideGlucocorticoid receptortarget
DB01222BudesonideCytochrome P450 3A4enzyme
DB08936ChlorcyclizineHistamine H1 receptortarget
DB01114ChlorphenamineHistamine H1 receptortarget
DB01114ChlorphenamineCytochrome P450 3A4enzyme
DB01114ChlorphenamineCytochrome P450 2D6enzyme
DB01114ChlorphenamineSodium-dependent serotonin transportertarget
DB01114ChlorphenamineSodium-dependent noradrenaline transportertarget
DB01114ChlorphenamineSodium-dependent dopamine transportertarget
DB01114ChlorphenamineCytochrome P450 3A5enzyme
DB01114ChlorphenamineCytochrome P450 3A7enzyme
DB01114ChlorphenamineSolute carrier family 22 member 2transporter
DB01114ChlorphenamineSolute carrier family 22 member 1transporter
DB09555Dexchlorpheniramine maleateCytochrome P450 2D6enzyme
DB09555Dexchlorpheniramine maleateHistamine H1 receptortarget
DB09555Dexchlorpheniramine maleateSolute carrier family 22 member 1carrier
DB09555Dexchlorpheniramine maleateSolute carrier family 22 member 2carrier
DB09555Dexchlorpheniramine maleateCytochrome P450 3A4enzyme
DB01075DiphenhydramineCytochrome P450 2D6enzyme
DB01075DiphenhydramineCytochrome P450 1A2enzyme
DB01075DiphenhydramineCytochrome P450 2C9enzyme
DB01075DiphenhydramineCytochrome P450 2C19enzyme
DB01075DiphenhydramineCytochrome P450 2C18enzyme
DB01075DiphenhydramineCytochrome P450 2B6enzyme
DB01075DiphenhydramineProstaglandin G/H synthase 1enzyme
DB01075DiphenhydramineHistamine H1 receptortarget
DB01075DiphenhydramineMuscarinic acetylcholine receptor M2target
DB01075DiphenhydramineSolute carrier family 22 member 2transporter
DB01075DiphenhydramineSolute carrier family 22 member 1transporter
DB01075DiphenhydramineSolute carrier family 22 member 5transporter
DB00062Human Serum AlbuminApolipoprotein Etarget
DB00062Human Serum AlbuminSerum amyloid A-1 proteintarget
DB00062Human Serum AlbuminProtein AMBPtarget
DB00062Human Serum AlbuminCytochrome P450 2C9enzyme
DB00062Human Serum AlbuminMyeloperoxidaseenzyme
DB00062Human Serum AlbuminUDP-glucuronosyltransferase 1-9enzyme
DB00557HydroxyzineHistamine H1 receptortarget
DB00557HydroxyzineCytochrome P450 2D6enzyme
DB06691MepyramineCytochrome P450 2D6enzyme
DB06691MepyramineHistamine H1 receptortarget
DB06691MepyramineSolute carrier family 22 member 4transporter
DB06691MepyramineSolute carrier family 22 member 5transporter
DB00427TriprolidineHistamine H1 receptortarget
DB00427TriprolidineCytochrome P450 2D6enzyme
DrugDrug NamePhaseStatusCount
DB13904Cat dander extract2Completed1
DB10399Felis catus skin2Completed1
DB01222Budesonide2 / 3Completed1
DB00169Cholecalciferol2 / 3Recruiting1
DB00967Desloratadine2 / 3Completed1
DB00153Ergocalciferol2 / 3Recruiting1
DB00983Formoterol2 / 3Completed1
DB00062Human Serum Albumin2 / 3Completed1
DB10394Phleum pratense pollen2 / 3Completed1
DB00635Prednisone2 / 3Completed1
DB01001Salbutamol2 / 3Completed1
DB11094Vitamin D2 / 3Recruiting1
DB12768BCG vaccine3Active Not Recruiting1
DB00283Clemastine3Unknown Status1
DB01234Dexamethasone3Unknown Status1
DB13867Fluticasone3Not Yet Recruiting1
DB00588Fluticasone propionate3Completed2
DB00588Fluticasone propionate3Not Yet Recruiting1
DB00764Mometasone3Not Yet Recruiting1
DB00972Azelastine4Not Yet Recruiting1
DB00169Cholecalciferol4Active Not Recruiting1
DB00153Ergocalciferol4Active Not Recruiting1
DB00303Ertapenem4Unknown Status1
DB00591Fluocinolone Acetonide4Completed1
DB00588Fluticasone propionate4Not Yet Recruiting1
DB00043Omalizumab4Unknown Status1
DB11614Rupatadine4Unknown Status1
DB09153Sodium Chloride4Unknown Status1
DB11094Vitamin D4Active Not Recruiting1
DB06361rsPSMA Vaccine4Completed1
DB10404Anthoxanthum odoratum pollenNot AvailableCompleted1
DB01410CiclesonideNot AvailableCompleted1
DB01234DexamethasoneNot AvailableRecruiting1
DB00588Fluticasone propionateNot AvailableCompleted1
DB00043OmalizumabNot AvailableCompleted1
DB00043OmalizumabNot AvailableRecruiting1
DB00043OmalizumabNot AvailableTerminated1
DB00860PrednisoloneNot AvailableRecruiting1