Allergies

Also known as: Allergy / Hypersensitivity NOS / Hypersensitivity reaction / Allergy NOS / Hypersensitivity reaction (NOS) / Reaction hypersensitivity (NOS) / Allergic reaction / Hypersensitivity / Allergic reaction NOS / Reaction allergic (NOS) / Allergic reaction (NOS) / HYSN / Hypersensitivity symptom

DrugDrug NameDrug Description
DB00835BrompheniramineHistamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. [PubChem]
DB01222BudesonideBudesonide is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. [PubChem] The extended release oral tablet, marketed as Uceris, was FDA approved on January 14, 2013 for the management of ulcerative colitis. Budesonide is provided as a mixture of two epimers (22R and 22S). Interestingly, the 22R form is two times more active than the 22S epimer. The two forms do not interconvert.
DB08936ChlorcyclizineChlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used as an antiemetic.
DB01114ChlorphenamineA histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]
DB14006Choline salicylateCholine salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever [L2129]. Choline Salicylate is the choline salt of salicylic acid, used as an analgesic, antipyretic and antirheumatic. It relieves mild to moderate pain and reduce fever and inflammation or swelling. Choline salicylate is effective in the treatment of gout, rheumatic fever, rheumatoid arthritis and muscle injuries [L2136]. This drug is also a main ingredient in teething gels to relieve pains associated with tooth growth in the infant population [L2134]. The UK government has regulated its use, due to toxicity in those under 16 years of age. Topical oral salicylate gels are no longer indicated for people younger than 16 years for pain associated with infant teething, orthodontic devices, cold sores, or mouth ulcers [L2134].
DB09555Dexchlorpheniramine maleateDexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.
DB01075DiphenhydramineDiphenhydramine, also known commercially as Benadryl, is a first generation antihistamine that is used primarily for the treatment of seasonal allergies. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system. While its use in in allergies has largely fallen out of favour due to this sedative effect, diphenhydramine has been repurposed for use within many OTC (over the counter) cough-and-cold medications that have been marketed for "night time" use. Diphenhydramine is also used in combination with [DB14132] as the anti-nausea drug [DB00985] where it is utilized primarily for its antagonism of H1 histamine receptors within the vestibular system [A1540]. Diphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect behaviour including dopamine, norepinephrine, serotonin, acetylcholine, and opioid [A1539]. As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties.
DB00062Human Serum AlbuminSerum albumin is the main protein of human blood plasma. It binds to water, cations (such as Ca2+, Na+ and K+), fatty acids, hormones, bilirubin, thyroxine (T4) and pharmaceuticals (including barbiturates). The main function of albumin is to maintain the oncotic pressure of blood [A33706]. There are various preparations of albumin that are well established and widely available in the clinical setting [L3108], [L3109], [L310]. Also known as _Albuminex_ 5% or 25%, one brand of human serum albumin is prepared from the pooled plasma of US donors in FDA-licensed facilities in the US [F229]. This is a biosimilar drug to existing human serum albumin and was approved for a biological license at both 5% and 25% concentrations by the FDA on June 21, 2018 [L3101].
DB00956HydrocodoneNarcotic analgesic related to codeine, but more potent and more addicting by weight. It is used also as cough suppressant.
DB00557HydroxyzineA histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. [PubChem]
DB06691MepyramineMepyramine (also known as pyrilamine) is a first generation antihistamine, targeting the H1 receptor. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It is used in over-the-counter combination products for colds and menstrual symptoms.
DB01069PromethazineA phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. [PubChem]
DB00427TriprolidineFirst generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
DrugDrug NameTargetType
DB00835BrompheniramineHistamine H1 receptortarget
DB00835BrompheniramineMuscarinic acetylcholine receptor M1target
DB00835BrompheniramineMuscarinic acetylcholine receptor M2target
DB00835BrompheniramineMuscarinic acetylcholine receptor M3target
DB00835BrompheniramineMuscarinic acetylcholine receptor M4target
DB00835BrompheniramineMuscarinic acetylcholine receptor M5target
DB00835BrompheniramineCytochrome P450 2B6enzyme
DB00835BrompheniramineCytochrome P450 2C19enzyme
DB00835BrompheniramineCytochrome P450 2C8enzyme
DB00835BrompheniramineCytochrome P450 2C9enzyme
DB00835BrompheniramineCytochrome P450 2E1enzyme
DB00835BrompheniramineCytochrome P450 3A4enzyme
DB01222BudesonideGlucocorticoid receptortarget
DB01222BudesonideCytochrome P450 3A4enzyme
DB01222BudesonideCytochrome P450 3A5enzyme
DB01222BudesonideBile salt export pumptransporter
DB08936ChlorcyclizineHistamine H1 receptortarget
DB01114ChlorphenamineHistamine H1 receptortarget
DB01114ChlorphenamineCytochrome P450 3A4enzyme
DB01114ChlorphenamineCytochrome P450 2D6enzyme
DB01114ChlorphenamineSodium-dependent serotonin transportertarget
DB01114ChlorphenamineSodium-dependent noradrenaline transportertarget
DB01114ChlorphenamineSodium-dependent dopamine transportertarget
DB01114ChlorphenamineCytochrome P450 3A5enzyme
DB01114ChlorphenamineCytochrome P450 3A7enzyme
DB01114ChlorphenamineSolute carrier family 22 member 2transporter
DB01114ChlorphenamineSolute carrier family 22 member 1transporter
DB14006Choline salicylateCholine-phosphate cytidylyltransferase Btarget
DB14006Choline salicylateAcetylcholinesterasetarget
DB14006Choline salicylateCholine-phosphate cytidylyltransferase Atarget
DB14006Choline salicylatePhospholipase D2target
DB14006Choline salicylateCholinesterasetarget
DB14006Choline salicylatePhospholipase D1target
DB14006Choline salicylatePhosphoethanolamine/phosphocholine phosphatasetarget
DB14006Choline salicylateSolute carrier family 22 member 2transporter
DB14006Choline salicylateSolute carrier family 22 member 1transporter
DB14006Choline salicylateSolute carrier family 22 member 3transporter
DB14006Choline salicylateSolute carrier family 22 member 5transporter
DB14006Choline salicylateSolute carrier family 22 member 4transporter
DB14006Choline salicylateCholine/ethanolaminephosphotransferase 1enzyme
DB14006Choline salicylateCholine transporter-like protein 1transporter
DB14006Choline salicylateCholine transporter-like protein 4transporter
DB14006Choline salicylateCholine transporter-like protein 2transporter
DB14006Choline salicylateCholine transporter-like protein 3transporter
DB14006Choline salicylateCholine/ethanolamine kinaseenzyme
DB14006Choline salicylateCholine O-acetyltransferaseenzyme
DB14006Choline salicylateCholine kinase alphaenzyme
DB14006Choline salicylateCholine dehydrogenase, mitochondrialenzyme
DB14006Choline salicylateHigh affinity choline transporter 1transporter
DB14006Choline salicylateNeuronal acetylcholine receptor subunit alpha-7target
DB09555Dexchlorpheniramine maleateCytochrome P450 2D6enzyme
DB09555Dexchlorpheniramine maleateHistamine H1 receptortarget
DB09555Dexchlorpheniramine maleateSolute carrier family 22 member 1carrier
DB09555Dexchlorpheniramine maleateSolute carrier family 22 member 2carrier
DB09555Dexchlorpheniramine maleateCytochrome P450 3A4enzyme
DB01075DiphenhydramineHistamine H1 receptortarget
DB01075DiphenhydramineCytochrome P450 2D6enzyme
DB01075DiphenhydramineCytochrome P450 2C9enzyme
DB01075DiphenhydramineCytochrome P450 2C19enzyme
DB01075DiphenhydramineCytochrome P450 2C18enzyme
DB01075DiphenhydramineSolute carrier family 22 member 2transporter
DB01075DiphenhydramineSolute carrier family 22 member 1transporter
DB01075DiphenhydramineSolute carrier family 22 member 5transporter
DB01075DiphenhydramineProstaglandin G/H synthase 1enzyme
DB01075DiphenhydramineMuscarinic acetylcholine receptor M2target
DB00956HydrocodoneMu-type opioid receptortarget
DB00956HydrocodoneDelta-type opioid receptortarget
DB00956HydrocodoneCytochrome P450 3A4enzyme
DB00956HydrocodoneCytochrome P450 2D6enzyme
DB00557HydroxyzineHistamine H1 receptortarget
DB00557HydroxyzineCytochrome P450 2D6enzyme
DB06691MepyramineCytochrome P450 2D6enzyme
DB06691MepyramineHistamine H1 receptortarget
DB06691MepyramineSolute carrier family 22 member 4transporter
DB06691MepyramineSolute carrier family 22 member 5transporter
DB01069PromethazineD(2) dopamine receptortarget
DB01069PromethazineHistamine H1 receptortarget
DB01069PromethazineMuscarinic acetylcholine receptor M4target
DB01069PromethazineMuscarinic acetylcholine receptor M1target
DB01069PromethazineMuscarinic acetylcholine receptor M5target
DB01069PromethazineAlpha-1A adrenergic receptortarget
DB01069Promethazine5-hydroxytryptamine receptor 2Atarget
DB01069PromethazineMuscarinic acetylcholine receptor M2target
DB01069PromethazineMuscarinic acetylcholine receptor M3target
DB01069PromethazineCalmodulintarget
DB01069PromethazineCytochrome P450 2D6enzyme
DB01069PromethazineCytochrome P450 2B6enzyme
DB01069PromethazineMultidrug resistance protein 1transporter
DB01069PromethazineCytochrome P450 2C9enzyme
DB01069PromethazineHistamine H2 receptortarget
DB00427TriprolidineHistamine H1 receptortarget
DrugDrug NamePhaseStatusCount
DB00742Mannitol0Completed1
DB01222Budesonide1Completed1
DB00341Cetirizine1Completed1
DB00283Clemastine1Completed1
DB06282Levocetirizine1Completed1
DB11856Ligelizumab1Completed1
DB01069Promethazine1Completed1
DB13904Cat dander extract2Completed1
DB10399Felis catus skin2Completed1
DB00043Omalizumab2Completed1
DB00043Omalizumab2Terminated1
DB01222Budesonide2 / 3Completed1
DB00169Cholecalciferol2 / 3Recruiting1
DB00967Desloratadine2 / 3Completed1
DB00153Ergocalciferol2 / 3Recruiting1
DB00983Formoterol2 / 3Completed1
DB00062Human Serum Albumin2 / 3Completed1
DB10394Phleum pratense pollen2 / 3Completed1
DB00635Prednisone2 / 3Completed1
DB01001Salbutamol2 / 3Completed1
DB11094Vitamin D2 / 3Recruiting1
DB12768BCG vaccine3Active Not Recruiting1
DB00283Clemastine3Unknown Status1
DB01234Dexamethasone3Unknown Status1
DB13867Fluticasone3Not Yet Recruiting1
DB00588Fluticasone propionate3Completed2
DB00588Fluticasone propionate3Not Yet Recruiting1
DB00455Loratadine3Completed2
DB00764Mometasone3Completed2
DB00764Mometasone3Not Yet Recruiting1
DB00635Prednisone3Completed2
DB01001Salbutamol3Completed2
DB00972Azelastine4Recruiting1
DB00341Cetirizine4Completed2
DB00169Cholecalciferol4Completed1
DB00967Desloratadine4Completed2
DB00153Ergocalciferol4Completed1
DB00303Ertapenem4Unknown Status1
DB00591Fluocinolone acetonide4Completed1
DB00588Fluticasone propionate4Recruiting1
DB00994Neomycin4Completed1
DB00043Omalizumab4Unknown Status1
DB11614Rupatadine4Unknown Status1
DB09153Sodium Chloride4Unknown Status1
DB11094Vitamin D4Completed1
DB06361rsPSMA Vaccine4Completed1
DB01060AmoxicillinNot AvailableCompleted1
DB10404Anthoxanthum odoratum pollenNot AvailableCompleted1
DB01410CiclesonideNot AvailableCompleted1
DB01234DexamethasoneNot AvailableRecruiting1
DB00588Fluticasone propionateNot AvailableCompleted1
DB00043OmalizumabNot AvailableCompleted1
DB00043OmalizumabNot AvailableRecruiting1
DB00043OmalizumabNot AvailableTerminated1
DB00860PrednisoloneNot AvailableRecruiting1