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Identification
NameThiamine
Accession NumberDB00152  (NUTR00009, APRD00552, EXPT03222)
TypeSmall Molecule
GroupsApproved, Nutraceutical, Vet Approved
Description

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.

Structure
Thumb
Synonyms
3-(4-AMINO-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium
Aneurin
Antiberiberi factor
Thiamin
Thiamine
thiamine(1+)
thiamine(1+) ion
thiaminium
Vitamin B1
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
B1 400mg Ctr Tabtablet (extended-release)400 mgBioenergy Inc.1979-12-311998-06-03Canada
Betaxinsolution100 mgintramuscular; intravenousHospira Healthcare Corporation2002-06-01Not applicableCanada
Betaxin Liq 100mg/mlliquid100 mgintramuscular; intravenousSanofi Canada, Inc.1936-12-312001-08-10Canada
Thiamiject Injection - Liq Im IV 100mg/mlliquid100 mgintramuscular; intravenousOmega Laboratories Ltd1998-07-16Not applicableCanada
Thiamine HCl Inj 100mg/mlliquid100 mgintramuscular; intravenousKripps Pharmacy Ltd.1979-12-31Not applicableCanada
Thiamine HCl Injection - Liq 100mg/mlliquid100 mgintramuscular; intravenousFaulding (Canada) Inc.1998-04-302001-07-30Canada
Thiamine Hydrochloride Inj 100mg/mlliquid100 mgintramuscularSaanich Pharmacy1988-12-311997-02-20Canada
Thiamine Hydrochloride Injection USP, 100mg/mlliquid100 mgintramuscular; intravenousAlveda Pharmaceuticals IncNot applicableNot applicableCanada
Thiamine Hydrochloride Injection, USPliquid100 mgintramuscular; intravenousSterimax Inc2001-05-01Not applicableCanada
Vit B1 Ctr Srt 100mgtablet (extended-release)100 mgBioenergy Inc.1981-12-311998-06-03Canada
Vitamin B1solution100 mgintramuscular; intravenousSandoz Canada Incorporated1989-12-31Not applicableCanada
Vitamin B1solution100 mgintramuscular; intravenousMylan Pharmaceuticals Ulc1994-12-312015-11-03Canada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Thiamineinjection, solution100 mg/mLintramuscular; intravenousFresenius Kabi USA, LLC2000-09-012016-04-05Us
Thiamineinjection, solution100 mg/mLintramuscular; intravenousCardinal Health2000-09-012016-04-05Us
Thiamine Hydrochlorideinjection, solution100 mg/mLintramuscular; intravenousGeneral Injectables & Vaccines, Inc2010-09-012016-04-05Us
Thiamine Hydrochlorideinjection, solution100 mg/mLintramuscular; intravenousMylan Institutional LLC2013-06-042016-04-05Us
Thiamine Hydrochlorideinjection, solution100 mg/mLintramuscular; intravenousPhysicians Total Care, Inc.2001-04-182016-04-05Us
Thiamine Hydrochlorideinjection, solution100 mg/mLintramuscular; intravenousGeneral Injectables & Vaccines, Inc2013-08-212016-04-05Us
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acti-thiamine Caplet 100mgtablet100 mgoralActi Form Ltd.1991-12-312005-03-21Canada
B-1 Caps 500mgcapsule500 mgoralTwin Laboratories Inc.1995-12-311999-11-10Canada
B1 Tab 100mgtablet100 mgoralVita Health Products Inc1979-12-312002-07-31Canada
Bewon Elixirliquid.05 mgoralLaboratoires Charton Laboratories1995-12-311999-01-16Canada
Bewon Elixir 0.05mg/mlelixir.05 mgoralWyeth Ayerst Canada Inc.1994-12-311998-01-28Canada
Thiamine HCl Tab 100mgtablet100 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Thiamine HCl Tab 25mgtablet25 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312000-08-17Canada
Thiamine HCl Tab 50mgtablet50 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Thiamine Hydrochloride Inj 100mg/ml USPliquid100 mgintramuscular; intravenousDavid Bull Laboratories (Pty) Ltd.1991-12-311998-08-13Canada
Vita-amine Cap 100mgcapsule100 mgoralLes Laboratoires Vachon Inc.1991-12-311997-08-08Canada
Vitamin B-1 100 Mg Tabletstablet100 mgoralGeneral Nutrition Canada Inc.1997-05-062007-08-01Canada
Vitamin B-1 Thiamine HCl 100mgcapsule100 mgoralAlbi Naturals1999-04-302009-07-15Canada
Vitamin B1 100 mgcapsule100 mgoralFlora Manufacturing And Distributing Ltd.2002-03-152004-08-04Canada
Vitamin B1 100mgtablet100 mgoralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Vitamin B1 100mg Tablettablet100 mgoralNutricorp International2000-01-242009-08-05Canada
Vitamin B1 Tab 100mgtablet100 mgoralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1978-12-312002-07-29Canada
Vitamin B1 Tab 100mgtablet100 mgoralShoppers Drug Mart Inc.1980-12-311997-08-15Canada
Vitamin B1 Tab 100mg USPtablet100 mgoralPharmavite Llc1987-12-311998-09-08Canada
Vitamin B1 Tab 100mg USPtablet100 mgoralQuest Vitamins A Div Of Purity Life Health Products1987-12-312001-07-06Canada
Vitamin B1 Tab 2mg USPtablet2 mgoralLab Gernetic Int Ltee1985-12-311997-02-21Canada
Vitamin B1 Tablets 100mgtablet100 mgoralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
Vitamine B1 100 Mg - Tablettablet100 mgoralNobel Pharm Enr.1995-12-312001-10-15Canada
Vitamine B1 Tab 100mg USPtablet100 mgoralLaboratoire Lalco Inc.1986-12-312002-09-05Canada
International Brands
NameCompany
Betalin SEli Lilly
BiamineNot Available
Brand mixtures
NameLabellerIngredients
Acti-MN + B1 + C CapletActi Form Ltd.
Adult Formula 50+Wn Pharmaceuticals Ltd.
Alkadrenergy TabletsMorter Healthsystem
Alsimine W Vitamins A DAlsi Cie Ltee
Am CapsNew Vision Nutritionals Company
AntlervironClassical Remedia Ltd
AppedrineChattem Canada
Avon Nutrivance Stress FormulaAvon Canada Ulc
Avon Vitadvance Multi-kids CompleteAvon Canada Ulc
Awesome AnimalsNew Vision Nutritionals Company
B Complex TabJamieson Laboratories Ltd
B 50 CapsulesRheingold Food International Ltd.
B 6 PlusAnabolic Laboratories Inc.
B Complex 25mg Vitamin SupplementGarden State Nutritionals
B Complex 50 Vitamin CapBioforce Canada Inc.
B Complex 50+ CapletHealth Wise Nutrition Inc.
B Complex TabletsGolden Neo Life Diamite International, Limited
B Complex W C and B12 InjE L Stickley And Co Ltd.
B Complex W Vit C W Non-med Yeast&liver TabPharmavite Llc
B Complex With C 300mg TabPharmavite Llc
B Complex With Minerals TabSisu Inc.
B Compound 50mg TabGahler Enterprises Ltd.
B Plus C 300mg Timed ReleaseVita Health Products Inc
B Stress C + Iron & ViteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
B VirolRolmex International Inc.
B Vitamin Compound With B12 ThunasThuna Herbal Remedies Ltd.
B With C 500 CapPharmetics (2011) Inc
B-100 CapsNow Foods
B-100 Hi Potency B Vitamins TabNatrol, Inc.
B-100 Vitamin SupplementGarden State Nutritionals
B-50 ComplexVita Health Products Inc
B-50 Complex TabVita Health Products Inc
B-50 Hi Potency B Vitamins TabNatrol, Inc.
B-complexEnrich International
B-complex 100Great Earth Companies, Inc.
B-complex 50Great Earth Companies, Inc.
B-complex TabNature's Sunshine Products Of Canada Ltd.
B-complex TabletsShaklee Canada Inc
B-complex With Vitamin C, Biotin, Folic AcidWn Pharmaceuticals Ltd.
B-complex-50 TabJr Carlson Labs Inc
B-plexLand Art Inc.
B-plex 100Merit Pharmaceutical
B-plus - TabChampion's Choice Advanced Nutrition Inc.
B-stresselect - CapsuleSisu Inc.
B50 B Complex TabNutristar Health Products (1987) Inc.
B50 ComplexPreferred Nutrition Inc.
B6 Plus TabVita Health Products Inc
BacminMarnel Pharmaceuticals, Inc.
Balanced B-100 B-complex Vitamins TabPharmavite Llc
Balanced B-100 Timed ReleasePharmavite Llc
Balanced B-50 B-complex Vitamins TabPharmavite Llc
Balanced B-50 B-complex Vitamins, Timed RelePharmavite Llc
Balanced B-50 ComplexLeiner Health Products Inc.
Balanced B-complex Vit + Vit C&e TabPharmavite Llc
Balanced B100Hall Laboratories, Ltd.
Balanced B50 ComplexHall Laboratories, Ltd.
Beautel Supplement De Vitamines Et MineralNobel Pharm Enr.
Beminal 500 TabWhitehall Robins Inc.
Beminal 500 TabsWyeth Canada
Beminal W C Fortis InjAyerst Laboratories
Beminal With C Fortis CapWyeth Ayerst Canada Inc.
Beminal With C Fortis PwsWyeth Ayerst Canada Inc.
Bev 29 TabBeverly International Nutrition
Bev B-150Beverly International Nutrition
Biovim TabLe Naturiste J.M.B. Inc.
BiovitaIldong Pharmaceutical Co., Ltd.
Bugs Bunny and Friends Multiple VitaminsBayer Inc Consumer Care
Bugs Bunny Chew Multi Vit Plus IronMiles Canada Inc. Consumer Health Care Division
C-B ComplexAvacare, Division Of Jeunique International Inc.
C-forcePrairie Naturals
C.R.T. X Multivitamin & Mineral Powder MixMetaform Ltd.
Cal M TabAnabolic Laboratories Inc.
Calcium and Magnesium Plus Zinc, Manganese and Copper With Vitamins B, C and DHolistic Int. Inc., Division Of Virta Enterprises
Carbassist TabletsWyeth Consumer Healthcare Inc.
Cc IIAdded Dimensions
Cda-21 Vitamins With Non-medicinal Probiotic ComplexRx Vitamins Inc.
Cedevita Plus Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Cedevita Sugar-free Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Centrum Junior (chewable)Whitehall Robins Inc.
Centrum Junior Regular (chewable Tablets)Whitehall Robins Inc.
Chela Iron Plus C,b ComplexNu Life Nutrition Ltd.
Chela Potassium PlusNu Life Nutrition Ltd.
Chela-chromium 200Nu Life Nutrition Ltd.
Chela-manganese 50 PlusNu Life Nutrition Ltd.
Chew.multiple Vits.with Extra C for ChildrenRandle Pharmaceutical Inc.
Chewable Adult Multivitamins With MineralsPharmavite Llc
Chewable Children's Complete Multivitamins With Essential MineralsWn Pharmaceuticals Ltd.
Chewable Multiple Vit Plus Iron for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Extra CRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Iron TabRandle Pharmaceutical Inc.
Chewable Multiple Vitamins TabRandle Pharmaceutical Inc.
Chewable MultivitaminsWn Pharmaceuticals Ltd.
Chewable Multivitamins Plus IronWn Pharmaceuticals Ltd.
Chewable Multivitamins With Extra CWn Pharmaceuticals Ltd.
Children Choice Multivit Chewable TabSwiss Herbal Remedies Ltd.
Children's Chewable Multi VitaminsVita Health Products Inc
Children's Chewable Multi Vitamins With Iron TabletsVita Health Products Inc
Children's Chewable Multi-vitaminWn Pharmaceuticals Ltd.
Children's Chewable Multi-vitamin Complete With MineralsWn Pharmaceuticals Ltd.
Children's Chewable Multiple Vit.plus IronStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple VitaminsStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins - TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins (chewable Tablets)Pharmetics (2011) Inc
Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets)Pharmetics (2011) Inc
Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)Pharmetics (2011) Inc
Children's Chewable Multivitamins and MineralsLifestyles Canada Corporation
Children's Chewable Multivitamins With MineralsWn Pharmaceuticals Ltd.
Children's Chewable Vit and Min TabGahler Enterprises Ltd.
Children's Chewable Vitamins With Extra CVita Health Products Inc
Children's Chewable With IronNutricorp International
Children's MultivitaminsNutricorp International
Children's Multivitamins With IronNutricorp International
Children's Vitamins ChewableVita Health Products Inc
Childrens Chew Multi Vitamin TabNutristar Health Products (1987) Inc.
Childrens Chewable Multiple Vitamins TabPharmavite Llc
Childrens Chewable MultivitaminsRandle Labs Inc.
Childrens Chewable Multivitamins W IronRandle Labs Inc.
Childrens Chewable Vitamin TabPharmetics (2011) Inc
Childrens Chewable VitaminsGarden State Nutritionals
Childrens Multi Vit and Chelated MineralsNu Life Nutrition Ltd.
Chromease TabAnabolic Laboratories Inc.
Citranatal DHAMission Pharmacal Company
Citranatal RxMission Pharmacal Company
Complete Mega BWn Pharmaceuticals Ltd.
Complete Multivitamins and Minerals Tablets Timed ReleasePharmetics (2011) Inc
Complex 5 - PwrAst Research
Complex-75Frega Inc.
Complexe B 75mgPharmalab Inc.
Complexe B-75Frega Inc.
Concept DHAUs Pharmaceutical Corporation
Concept ObUs Pharmaceutical Corporation
Croq-vit Pour EnfantsNutrivac Ltee
CyroplexTherapeutic Foods Co.
D'pantothenic Acid-B1-B2 TabHealth Thru Herbs Inc.
Daily Energy Brand B-complexEnzymatic Therapy (Canada) Inc.
Derma-forcePrairie Naturals
Dexatrim TabletsChattem Canada
Dia-viteR & D Laboratories Inc.
DiaplexNephro Tech, Inc.
Diatrum DrageesLaboratoire Romilo
Diavim TabNutritia International Laboratoire
DinomalsAwareness Corporation
Dynam Ampoule Et TabletCardinaux Enrg Les Produits Naturels
E.S.T. ComplexAbundance Marketing Ltd.
Earthpals Children's Chewables Multi-vitamin & Mineral TabletsInternational Heritage, Inc.
Efferlife Multivitamins and MineralsNaturale Science Inc.
Enrich Core Pack - Children Vitamin and Mineral SupplementEnrich International
EnvirocomplexEnviro Tech International Canada
Enviroflex - TabEnviro Tech International Canada
EscaviteGm Pharmaceuticals, Inc.
Essential B TabletsGeneral Nutrition Canada Inc.
Essential Vitamins and MineralsWn Pharmaceuticals Ltd.
Everyday Multiple VitaminsD.C. Labs Limited
Everyday Multiple Vitamins With IronD.C. Labs Limited
Extra P.N. Vitamin-mineral Drink MixChanges International
Fem Time TabNu Life Nutrition Ltd.
Feminique W Iron and Calcium TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Ferra Naka Plus VitaminsNaka Sales Ltd.
Flex-O-flex Supplement Vitamines Et MinerauxNergy SantÉ Inc.
Flinstones Multiple Plus IronMiles Canada Inc. Consumer Health Care Division
Flintstones Multiple VitaminsBayer Inc Consumer Care
Flintstones Multiple Vitamins Plus IronBayer Inc Consumer Care
Flintstones Multiple Vitamins TabMiles Canada Inc. Consumer Health Care Division
Flintstones Multiple Vitamins With Extra CBayer Inc Consumer Care
Flintstones W Extra C TabMiles Canada Inc. Consumer Health Care Division
Floradix Formula LiqFlora Manufacturing And Distributing Ltd.
Floravit - SyrFlora Manufacturing And Distributing Ltd.
FlorivaBon Geo Pharmaceuticals, Inc.
Floriva PlusBon Geo Pharmaceuticals, Inc.
For Kids Only Chewable Multivit. Plus IronKsl Pharmaceuticals
For Kids Only Chewable MultivitaminsStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
For Kids Only Chewable Multivitamins - TabKsl Pharmaceuticals
For-2Holista Health (Canada) Inc.
Formula D.S.Golden Pride International
Formula Fm Vitamins & Minerals TabMetagenics, Inc.
Formula GmNutrivention Nutritional Products
Formula III Vit & Min Supp CapsSisu Inc.
Formula LfNumark Laboratories, Inc.
Formula Pro-BBalance Plus, Inc.
Formule StressSantÉ Naturelle (Ag) LtÉe
Fortaplex InjKripps Pharmacy Ltd.
Fortistress TabSantÉ Naturelle (Ag) LtÉe
Forty Plus Vitamin SupplementGarden State Nutritionals
G.A.S. ComplexAbundance Marketing Ltd.
Gemvites Jr Tab ChewablePharmavite Laboratories (1987) Inc.
Geritol LiquidGlaxosmithkline Consumer Healthcare Inc.
Geritol TabletsGlaxosmithkline Consumer Healthcare Inc.
Gestamine ComprimesLab Nadeau LtÉe, Division Of Technilab Inc.
Glyco-aide TabAvant Garde, Les SupplÉments
Golden Supreme Multivit and Multimin TabAvacare, Division Of Jeunique International Inc.
Gynedyn TabNutri Dyn Products Ltd.
Harvest Of Values All B Complex TabHillestad Pharmaceuticals Usa
Hemarexin AmpLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hemarexin TabLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hemenatal ObWh Nutritionals, Llc
Hi Potency B Complex W Chelated MineralsKlaire Labs Inc.
Hi Potency B52 B Complex TabCountry Health Laboratories Ltd.
Hi Potency Balanced B-100 Complex - TabLeiner Health Products Inc.
Hi Potency Stress B Tension With CLee Adams Laboratories
High Potency Vitamin & Mineral Dietary SupplementGarden State Nutritionals
Hill.viteHillestad Pharmaceuticals Usa
Hms 90Immunotec Inc
HommactifLe Naturiste J.M.B. Inc.
Hormodausse Plus Calc Et D TabLaboratoires Charton Laboratories
Hypo Vites TabPharmetics (2011) Inc
Image Hns CapNu Skin International, Inc.
Infa Drops MultivitaminsVita Health Products Inc
Infant Multivitamin DropsGeneral Nutrition Canada Inc.
Infantol DropsChurch & Dwight Canada Corp
Insur-all Vitamin SupplementGarden State Nutritionals
Integra PlusUs Pharmaceutical Corporation
Iron 25mg With Vit B-cmplx, Vit C, Cu & MoQuest Vitamins A Div Of Purity Life Health Products
Iron Free MultiWn Pharmaceuticals Ltd.
Iron Polysaccharides Folic Acid DHAVirtus Pharmaceuticals LLC
Iron/fer Complex TabJamieson Laboratories Ltd
Junior Multi Vitamins - RegularVita Health Products Inc
Kanga Sport Vitamins B & C Plus MineralsLacombe Drugs (1992) Ltd
Kanga-B Vitamin B Group + CLacombe Drugs (1992) Ltd
Kanga-kid Multi-vitamin & MineralLacombe Drugs (1992) Ltd
Kanga-kid Vitamins & IronLacombe Drugs (1992) Ltd
Kenwood Liquid SupplementKenwood Laboratories (Division Of Bradley Pharmaceuticals)
Kid's Choice Children's Chewable Vitamins - TabVita Health Products Inc
Kids Stuff TabletsVita Health Products Inc
Kids Stuff With Iron TabletsVita Health Products Inc
Kimchi Vitamin Chewable MultivitaminTobico
KindervitesHerbalife International Of America, Inc.
Leritone JuniorInstitut De Recherche Biologique Yves Ponroy Canada Inc.
LifepakNu Skin International, Inc.
Lifepak PrimeNu Skin International, Inc.
Lifepak WomenNu Skin International, Inc.
Liqui B ComplexTwin Laboratories Inc.
Liqui B Complex PlusTwin Laboratories Inc.
Liqui Infant VitaminsTwin Laboratories Inc.
Liqui VitaTwin Laboratories Inc.
Livron Plus AmpouleMedic Laboratory LtÉe
Low Potency B Complex TabFlora Manufacturing And Distributing Ltd.
Luna Vitamin and Mineral Bar for WomenClif Bar Inc.
Lysamine Diet Supp Amp-tabWelcker Lyster Ltd., Division Of Technilab Inc.
M.V.I. 12Aventis Pharma Inc
M.V.I. PaediatricAventis Pharma Inc
M.V.I. PediatricHospira Worldwide, Inc.
Magnum-75 Vitamin and Mineral SupplementGarden State Nutritionals
Maltlevol 12 LiqCarter Horner Corp.
Maltlevol LiqCarter Horner Corp.
Manganese 50mg Plus B1 & E TabSwiss Herbal Remedies Ltd.
MaternaWyeth Consumer Healthcare Inc.
Maxi 6 LiqDesbergers LtÉe, Division Of Technilab Inc.
Maxine Vitamin and Mineral SupplementNf Formulas Inc.
Mega 13 Multivitamin FormulaVita Health Products Inc
Mega B-50 - CapsuleSisu Inc.
Mega BalancePharmavite Llc
Mega Multiple Vitamins & Min TabTrophic Canada Ltd.
Mega VitamineralsHerbscience Custom Manufacturing
Megavites TabIcn Canada Ltd.
Men's Multi Master FormulaPro Ma Systems
Mini-B TabTwin Laboratories Inc.
Mor-vites TabPharmetics (2011) Inc
Multi - N.T.O.x Formula - TabAbundance Marketing Ltd.
Multi #2W 7 Clay Inc.
Multi 1000Sandoz Canada Incorporated
Multi 12 InjectionSandoz Canada Incorporated
Multi BSeroyal International Inc.
Multi Enfants TabVitalab
Multi II IV Vi TabSisu Inc.
Multi Nt-OXAbundance Marketing Ltd.
Multi RolRolmex International Inc.
Multi TabsFlora Manufacturing And Distributing Ltd.
Multi Vitamin - MineralEnrich International
Multi Vitamin & MineralsWn Pharmaceuticals Ltd.
Multi Vitamin and FluorideLibertas Pharma, Inc.
Multi Vitamin and Mineral Reg PackNature's Peak 2007 Ltd
Multi Vitamin Drops With FluorideSeton Pharmaceuticals
Multi Vitamin Drops With Fluoride and IronSeton Pharmaceuticals
Multi Vitamin Drops With Fluoride With IronStratus Pharmaceuticals
Multi Vitamin Plus IronWn Pharmaceuticals Ltd.
Multi Vitamin With FluorideQualitest Pharmaceuticals
Multi Vitamin-mineral FormulaVita Health Products Inc
Multi Vitamin, Iron and FluorideLibertas Pharma, Inc.
Multi Vitamins & MineralsWn Pharmaceuticals Ltd.
Multi Vite Liq AdultPharmetics (2011) Inc
Multi Vite Liq JuniorPharmetics (2011) Inc
Multi-11Sandoz Canada Incorporated
Multi-12 PediatricSabex Inc
Multi-12/k1 PediatricSandoz Canada Incorporated
Multi-force for Women TabBioforce Canada Inc.
Multi-kidLand Art Inc.
Multi-vit With FluorideQualitest Pharmaceuticals
Multi-vit With Fluoride and IronQualitest Pharmaceuticals
Multi-vitaminLLC Federal Solutions
Multi-vitamin Dietary SupplementGarden State Nutritionals
Multi-vitamin FluorideStratus Pharmaceuticals
Multi-vitamin Fluoride and Iron DropsBoca Pharmacal, LLC
Multi-vitamin Fluoride DropsH.J. Harkins Company, Inc.
Multi-vitamin With FluorideGolden State Medical Supply, Inc.
Multi-vitamines Enfants ComprimeHerbes Universelles Inc.
Multi-vitaminsWn Pharmaceuticals Ltd.
Multi-vitamins & MineralsNihon Kenko Zoushin Kenkyukai Canada Inc., Subsidery Of Nikken Usa Inc.
Multi-vitamins for Infusion LiqDavid Bull Laboratories (Pty) Ltd.
Multi-vitamins With MineralsWn Pharmaceuticals Ltd.
MulticapsFlora Manufacturing And Distributing Ltd.
Multiple Vitamin Plus Minerals TabHall Laboratories, Ltd.
Multiple Vitamin TabAdams Labs Ltd.
Multiple VitaminsGfr Pharma Ltd.
Multiple Vitamins and Minerals CapsulesStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins and Minerals TabRandle Labs Inc.
Multiple Vitamins Plus Iron for WomenPharmetics (2011) Inc
Multiple Vitamins Plus Iron TabHall Laboratories, Ltd.
Multiple Vitamins TabHall Laboratories, Ltd.
Multiple Vitamins W Iron TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins W Minerals TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins With IronStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Multiple Vitamins With Minerals TabletsPharmetics (2011) Inc
MultisolLes Laboratoires Vachon Inc.
MultitabsFlora Manufacturing And Distributing Ltd.
MultivimLe Naturiste J.M.B. Inc.
Multivit-liqPharmalab Inc.
MultivitaminLaboratoires Confab Inc
Multivitamin & Minerals (iron Free)Holista Health (Canada) Inc.
Multivitamin & MultimineralHolista Health (Canada) Inc.
Multivitamin and Mineral CapShoppers Drug Mart Inc.
Multivitamin With FluorideSancilio & Company Inc
MultivitaminesRolmex International Inc.
Multivitamines Et MinerauxLe Groupe M. Vachon Inc.
Multivitamines Plus C Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
Multivitamines Plus Fer Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
Multivitamines Pour Enfants (chewable Tablets)Laboratoire Lalco Inc.
MultivitaminsVita Health Products Inc
Multivitamins for ChildrenQuest Vitamins A Div Of Purity Life Health Products
Multivitamins W IronRandle Labs Inc.
Multivitamins W Minerals Extra StrengthWatkins Incorporated
MvcSancilio & Company Inc
Mvc-fluorideSancilio & Company Inc.
Mynephrocaps Dialysis/stress Vitamin SupplementMartin Ekwealor Pharmaceuticals, Inc.
Nata KompleteWh Nutritionals, Llc
NatafortMission Pharmacal Company
NataviteSchein Pharmaceutical Canada Inc.
Neo Bex ElixirNeolab Inc
Neo Vites TabNeolab Inc
Neo-bexNeolab Inc
Neo-bex InjectableBrostel Inc.
Neo-vites & Minerals TabNeolab Inc
NephrocapsCardinal Health
New Chapter's D'adamo 4 Your Type Multiple for Type ONew Chapter, Inc.
Nutri-life Multivit & Mineral SupplementRheingold Food International Ltd.
Nutrol-B-complexRolmex International Inc.
O-cal Fa MultivitaminPharmics, Inc.
O-cal Prenatal VitaminPharmics, Inc.
Olympian Multi Vit Plus Minerals TabWeider Health Products
OnccorSimone Protective Pharmaceuticals, Inc.
OncoviteSeaford Pharmaceuticals Inc
One A Day Advance AdultsBayer Inc Consumer Care
One A Day Advance FemBayer Inc Consumer Care
One A Day Multiple Vit W MineralsAlbi Naturals
One A Day TabCountry Health Laboratories Ltd.
One Daily Vitamin and Mineral Dietary SupplementGarden State Nutritionals
One Tablet Daily High Potency B Complex and CVita Health Products Inc
One Tablet Daily Mens FormulaVita Health Products Inc
Opti-manganese + B1 + C CapletNu Life Nutrition Ltd.
Orange Flavored Crystal Chews TabJeunique International Inc.
Orifer FSanofi Aventis Canada Inc
Original Bioscal Forte Multi-vitamin Supplement CapsulesCarram Inc.
Orti BSeroyal International Inc.
Osteo-forcePrairie Naturals
Overdrive - CapNu Skin International, Inc.
P.N. Vitamin-mineral DrinkChanges International
P.N.P. Vitamin DrinkChanges International
P.R.O. ComplexAbundance Marketing Ltd.
Penta-thion PwrSabex Inc
Permathene-12 - CapletCCA Industries, Inc.
Phosthenine Vitamines Et Fer (ampoules Buvable)Laboratoires Cortunon Inc.
Phytofortis + Calcium A-DProduits Phyto Inc.
Phytoplex B LiqProduits Phyto Inc.
PhytopureLaboratoire Lalco Inc.
PM CapsNew Vision Nutritionals Company
Pnv Ferrous Fumarate Docusate Folic AcidVirtus Pharmaceuticals LLC
Pnv Prenatal Plus MultivitaminSancilio & Company Inc
Pnv Prenatal VitaminSancilio & Company Inc
Pnv Prenatal Vitamin Plus Vitamin ASancilio & Company Inc
Pnv-firstAcella Pharmaceuticals, LLC
Pnv-selectAcella Pharmaceuticals, LLC
Poly-VI-sol DropsMead Johnson Nutritionals
Polymine Avec Zinc Et CuivreLes Laboratoires Vachon Inc.
Prefera Ob Plus DHAAlaven Pharmaceutical LLC
PreferaobMEDA Pharmaceuticals
Preferaob Plus DHAAlaven Pharmaceutical LLC
PregvitDuchesnay Inc
Pregvit Folic 4Duchesnay Inc
Pregvit Folic 5Duchesnay Inc
Prenatal 19Nationwide Laboratories, LLC
Prenatal and Post Partum SupplementVita Health Products Inc
Prenatal Mega AntioxidantUsana Health Services, Inc.
Prenatal PlusBlenheim Pharmacal, Inc.
Prenatal Vi-minHolista Health (Canada) Inc.
Prenatal Vitamins and Minerals TabletsPharmetics (2011) Inc
Prenatal Vitamins Plusbryant ranch prepack
Prenatal Vitamins Plus Low IronPatrin Pharma, Inc.
Prenate EliteAvion Pharmaceuticals, Llc
Prenate StarAvion Pharmaceuticals, Llc
PreplusVirtus Pharmaceuticals LLC
PretabVirtus Pharmaceuticals LLC
PrévitaBio Vita
Prevital TabBio Vita
Prim - Royal P.M.T.Abundance Marketing Ltd.
Purevit Dualfe PlusPure Tek Corporation
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Revit Plus CapIcn Canada Ltd.
Revit TabIcn Canada Ltd.
Revitex Ampoules Et ComprimesLes Produits Gerbex Inc.
Revival 1 TabBio Vita
Right Choice A.M. Multi Formula - CapletBody Wise International Llc
S-pan-F TabNutri West Products Ltd.
S-pan-M TabNutri West Products Ltd.
Se-natal 19Seton Pharmaceuticals
Se-natal 19 ChewableSeton Pharmaceuticals
Se-natal OneSeton Pharmaceuticals
Se-tan PlusSeton Pharmaceuticals
Sibergin B - CapPharmavite Llc
Sisu Chewable Multivitamin and MineralSisu Inc.
Somarexin and C 1000Laboratoire Lalco Inc.
Somavit Brand Vitamins and Minerals ComplexSoma Health Products
Sopalamine 3b PlusLaboratoires Charton Laboratories
Sopalamine/3b TabTechnilab Pharma Inc.
Spectrum 2 CapNf Formulas Inc.
Spectrum 4 CapNf Formulas Inc.
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Stress B Capsules With Vitamin CRheingold Food International Ltd.
Stress B Complex With C, E & IronPharmavite Llc
Stress B With 1000 Mg Vitamin CHolista Health (Canada) Inc.
Stress Complex 600 Avec Vit E Cuivre ZincFrega Inc.
Stress Ctr SrtBioenergy Inc.
Stress FormulaVita Health Products Inc
Stress Formula + IronVita Health Products Inc
Stress Formula B-comp + 500mg Vit C TabQuest Vitamins A Div Of Purity Life Health Products
Stress Formula Multi-B Comp + 500mg Vit C CapQuest Vitamins A Div Of Purity Life Health Products
Stress Formula Multivitamin Tablets USPLeiner Health Products Inc.
Stress Formula TabNature's Sunshine Products Of Canada Ltd.
Stress Formula Vit B With C ComplexWatkins Incorporated
Stress Forte Plus Lipotropic FactorsDouglas Laboratories
Stress Tab With Iron and Vitamin EVita Health Products Inc
Stress Tab With Zinc, Copper and Vitamin EVita Health Products Inc
Stress Vitamin B With C Complex TabletsPurity Life Health Products A Division Of Sunopta Inc.
Stressease Plus Vitamins and MineralsJamieson Laboratories Ltd
StressmatesTwin Laboratories Inc.
Strovite Forte CapletEverett Laboratories, Inc.
Strovite One CapletsEverett Laboratories, Inc.
Summit Gold TabletsHillestad Pharmaceuticals Usa
Sun-rype VitaburstSun Rype Products Ltd.
Super B ComplexSisu Inc.
Super Daily No 2W.R. Enterprises Inc.
Super Hy-vites Extra StrengthGreat Earth Companies, Inc.
Super Hy-vites Regular StrengthGreat Earth Companies, Inc.
Super Kids Chewable Multivitamin Multimineral (chewable Tablets)Swiss Herbal Remedies Ltd.
Super MultiNatural Factors Nutritional Products Ltd.
Super PantoplexNu Life Nutrition Ltd.
Super Stress CapsulesRheingold Food International Ltd.
Super Stress Mega B Plus 1000mg Vit C TabQuest Vitamins A Div Of Purity Life Health Products
Super Vitalex Ampoule BuvableCarmaran LtÉe
Super Vitamins & Minerals TabNature's Sunshine Products Of Canada Ltd.
Super-pote Vitamin SupplementGarden State Nutritionals
Supplement De Multivitamines Infusion Arome Fruits RougesYves Rocher Inc.
Supravite 10ml AmpouleNobel Pharm Enr.
Supravite Bouteille 250mlNobel Pharm Enr.
Supravite C 1000Nobel Pharm Enr.
Supravite Pour EnfantsPharmalab Inc.
Supravite Stress Avec Vit EPharmalab Inc.
Supravite Stress Avec Vit E Cuivre Et ZincPharmalab Inc.
Supravite Stress Avec Vit E Et FerPharmalab Inc.
Surbex-500 With ZincAbbott Laboratories, Limited
Swical-energy 3e AgeLes Laboratoires Swisse Inc.
Swical-energy-2Les Laboratoires Swisse Inc.
Swiss One Timed Release TabSwiss Herbal Remedies Ltd.
Swiss Total OneSwiss Herbal Remedies Ltd.
Synergistic Manganese CapsulesQuest Vitamins A Div Of Purity Life Health Products
T.R. Swiss One '80' Multivitamin & MineralSwiss Herbal Remedies Ltd.
T.R.I. B-plex SrcAnabolic Laboratories Inc.
T.R.I. ComplexAbundance Marketing Ltd.
Tandem ObUs Pharmaceutical Corporation
Tandem PlusUs Pharmaceutical Corporation
Tender Age Multi VitaminsJamieson Laboratories Ltd
Thiamine HCl 100mg W C 20mgGahler Enterprises Ltd.
Tianshi Calcium II Mineral Supplement With Vitamins A,d,c,b1 and B2Tianshi Health Products Inc.
Timed Release B Complex 100 SrtJamieson Laboratories Ltd
Timed Release B-complex 100Great Earth Companies, Inc.
Timed Release B-complex 50Great Earth Companies, Inc.
Tini-cal AmpoulesPharmetics (2011) Inc
Toni Com LiqVitalab
Tonicol Et A-D-C Ampoules/comprimesDistributions Multi Pro Inc.
Tonimol Cap LiqHerbes Universelles Inc.
Totalvit PlusSomapharm (Division Of Bariatrix Nutrition Inc.)
TriadvanceTrigen Laboratories, Inc.
Tricare PrenatalMedecor Pharma, Llc
Trinatal GtTrigen Laboratories, Inc.
Twin Ultra Liquid Fruit Punch FlavorTwin Laboratories Inc.
Twin Ultra Liquid Grape FlavorTwin Laboratories Inc.
Twin Ultra Liquid Lemon-lime FlavorTwin Laboratories Inc.
Twin Ultra Liquid Orange FlavorTwin Laboratories Inc.
Ultra EnerforceNutribon (1986) Inc.
Ultra HrNatural Organics Inc.
Usana Chooables Tablets (chewable Tablets)Usana Health Sciences Inc.
Usana Megavitamin Tablets - TabUsana Health Sciences Inc.
Usanimals TabletsUsana Health Sciences Inc.
V & M Vitamin and Mineral SupplementGarden State Nutritionals
V-natalVirtus Pharmaceuticals
Vasula TabTherapeutic Foods Co.
Vege 1 Daily TabNu Life Nutrition Ltd.
Viamon Ampoules Et ComprimesLab Nadeau LtÉe, Division Of Technilab Inc.
Vigem 12 LiquidPharmavite Laboratories (1987) Inc.
Vigo Multivitamins Drops/lozengeAshbury Research Corporation
Virt-bal DHA PlusVirtus Pharmaceuticals
Virt-capsVirtus Pharmaceuticals LLC
Virt-PNVirtus Pharmaceuticals
Virt-vite PlusVirtus Pharmaceuticals LLC
Vit B Complex CtrBioenergy Inc.
Vita B + C 500 TabLaboratoire Romilo
Vita Day TabJamieson Laboratories Ltd
Vita Vim TabJamieson Laboratories Ltd
Vita-BNutri Dyn Products Ltd.
Vita-B-75 CapLes Laboratoires Vachon Inc.
Vita-worth B-complex TabletsGeneral Nutrition Canada Inc.
Vitabanks Vitamin TabVitabank Inc.
Vitachrom GcNikken Usa, Incorporated
Vitaday TabPharmetics (2011) Inc
VitafantLes Laboratoires Vachon Inc.
Vitafer - LiqFrega Inc.
Vitaflex Dietary SuplementHome Shopping Network Direct
Vitafol CapletEverett Laboratories, Inc.
Vitafol Ob CapletEverett Laboratories, Inc.
Vitafol OneEverett Laboratories, Inc.
Vitafol PlusEverett Laboratories, Inc.
Vitafol UltraEverett Laboratories, Inc.
Vital Be-100Media Power, Inc.
Vitamin & Mineral Formula 1 Dietary SupplementGarden State Nutritionals
Vitamin B + C CapFinlandia Consultants
Vitamin B ComplexMylan Institutional LLC
Vitamin B Complex + C 300mg CapRandle Labs Inc.
Vitamin B Complex + C 600mg TabRandle Labs Inc.
Vitamin B Complex 100 TabBioforce Canada Inc.
Vitamin B Complex 50Gfr Pharma Ltd.
Vitamin B Complex Plus 300mg Vitamin CHall Laboratories, Ltd.
Vitamin B Complex Plus C 300mg Timed ReleaseVita Health Products Inc
Vitamin B Complex SupplAvacare, Division Of Jeunique International Inc.
Vitamin B Complex TabNutristar Health Products (1987) Inc.
Vitamin B Complex W C TabAlbi Imports Ltd.
Vitamin B Compound TabNutrilite, A Division Of Access Business Group, Llc
Vitamin B Compound W Vit C 250mg TabSwiss Herbal Remedies Ltd.
Vitamin B Cpd W Vit C TabIcn Canada Ltd.
Vitamin B TabletsWeider Health Products
Vitamin Mineral PwrGahler Enterprises Ltd.
Vitamine 110 LiqFrega Inc.
Vitamine Du Groupe B Plus Fer - LiqPharmalab Inc.
Vitamines Et MinerauxHerbes Universelles Inc.
Vitamines Et Mineraux ComprimesHerbes Universelles Inc.
Vitamines Et Mineraux Enfants 970Herbes Universelles Inc.
Vitamines Pour Bebes Et EnfantsHerbes Universelles Inc.
Vitamins W Iron ChewableStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
VitaplexSantÉ Naturelle (Ag) LtÉe
VitathionServier Canada Inc
Vitogen B Compound W C Fortis CapsulesStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Vitogen B Stress C Vit E Zinc & CopStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Vitogen B Stress C600Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Vivalmin 2 TabBio Vita
Vp-heme ObVirtus Pharmaceuticals LLC
Vtb Vitamin and Mineral SupplementGarden State Nutritionals
VyquaSanteplus Ltd.
Women's Change FormulaGeneral Nutrition Canada Inc.
Women's FormulaPro Ma Systems
Salts
Name/CASStructureProperties
Thiamine Hydrochloride
67-03-8
Thumb
  • InChI Key: DPJRMOMPQZCRJU-UHFFFAOYSA-M
  • Monoisotopic Mass: 336.057837322
  • Average Mass: 337.269
DBSALT000205
Thiamine mononitrate
ThumbNot applicableDBSALT001495
Categories
UNIIX66NSO3N35
CAS number59-43-8
WeightAverage: 265.355
Monoisotopic: 265.112306876
Chemical FormulaC12H17N4OS
InChI KeyInChIKey=JZRWCGZRTZMZEH-UHFFFAOYSA-N
InChI
InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1
IUPAC Name
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium
SMILES
CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as thiamines. These are compounds containing a thiamine moiety, which is structurally chracterized by a 3-[(4-Amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-5-yl backbone.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazines
Sub ClassPyrimidines and pyrimidine derivatives
Direct ParentThiamines
Alternative Parents
Substituents
  • Thiamine
  • Aminopyrimidine
  • 4,5-disubstituted 1,3-thiazole
  • Imidolactam
  • Primary aromatic amine
  • Heteroaromatic compound
  • Thiazole
  • Azole
  • Azacycle
  • Hydrocarbon derivative
  • Primary amine
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Organic cation
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.
PharmacodynamicsThiamine is a vitamin with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities. Thiamine has been found to protect against lead-induced lipid peroxidation in rat liver and kidney. Thiamine deficiency results in selective neuronal death in animal models. The neuronal death is associated with increased free radical production, suggesting that oxidative stress may play an important early role in brain damage associated with thiamine deficiency. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Inhibition of endothelial cell proliferation may also promote atherosclerosis. Endothelial cells in culture have been found to have a decreased proliferative rate and delayed migration in response to hyperglycemic conditions. Thiamine has been shown to inhibit this effect of glucose on endothelial cells.
Mechanism of actionIt is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. There are five known natural thiamine phosphate derivatives: thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and the recently discovered adenosine thiamine triphosphate (AThTP), and adenosine thiamine diphosphate. Each derivative has unique functions, however, most are involved as coenzymes.
Related Articles
AbsorptionAbsorbed mainly from duodenum, by both active and passive processes
Volume of distributionNot Available
Protein binding90-94%
Metabolism

Hepatic

Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityThiamine toxicity is uncommon; as excesses are readily excreted, although long-term supplementation of amounts larger than 3 gram have been known to cause toxicity. Oral mouse LD50 = 8224 mg/kg, oral rat LD50 = 3710 mg/kg.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Thiamine MetabolismMetabolicSMP00076
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.7976
Blood Brain Barrier+0.933
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.5593
P-glycoprotein inhibitor INon-inhibitor0.9814
P-glycoprotein inhibitor IINon-inhibitor0.8504
Renal organic cation transporterNon-inhibitor0.7559
CYP450 2C9 substrateNon-substrate0.842
CYP450 2D6 substrateNon-substrate0.7591
CYP450 3A4 substrateNon-substrate0.7256
CYP450 1A2 substrateNon-inhibitor0.58
CYP450 2C9 inhibitorNon-inhibitor0.7521
CYP450 2D6 inhibitorNon-inhibitor0.7523
CYP450 2C19 inhibitorNon-inhibitor0.7397
CYP450 3A4 inhibitorNon-inhibitor0.8019
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7795
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8999
BiodegradationNot ready biodegradable0.86
Rat acute toxicity2.4577 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9415
hERG inhibition (predictor II)Non-inhibitor0.6221
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Eli lilly and co
  • Abraxis pharmaceutical products
  • Akorn inc
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia and critical care
  • Bel mar laboratories inc
  • Dell laboratories inc
  • Hospira inc
  • Luitpold pharmaceuticals inc
  • Parke davis div warner lambert co
  • Watson laboratories inc
  • Wyeth ayerst laboratories
Packagers
Dosage forms
FormRouteStrength
Tabletoral100 mg
Liquid; capsuleoral
Tablet (extended-release)oral
Capsuleoral500 mg
Injection, solutionintramuscular; intravenous
Tablet (extended-release)400 mg
Powder for solutionintramuscular; intravenous
Powder for solutionintravenous
Liquidoral.05 mg
Elixiroral.05 mg
Granuleoral
Tabletoral
Syruporal
Liquidintramuscular; intravenous
Tablet (effervescent)oral
Dropsoral
Bar (chewable)oral
Injection, powder, lyophilized, for solutionintravenous
Solutionintravenous
Capsule; tabletoral
Solution/ dropsoral
Liquidoral
Solutionoral
Liquidintravenous
Tablet, chewableoral
Elixiroral
Solutionintramuscular; intravenous
Powderoral
Tablet, coatedoral
Liquid; tabletoral
Packageoral
Capsule (sustained-release)oral
Liquidintramuscular; intravenous100 mg
Tabletoral25 mg
Tabletoral50 mg
Injection, solutionintramuscular; intravenous100 mg/mL
Liquidintramuscular100 mg
Lozengeoral
Kit
Tablet (extended-release)
Tablet (extended-release)100 mg
Capsuleoral100 mg
Tablet
Capsuleoral
Capsule, gelatin coatedoral
Capsule, liquid filledoral
Injectionintravenous
Capsule
Solutionintramuscular; intravenous100 mg
Tabletoral2 mg
Tablet, film coatedoral
Prices
Unit descriptionCostUnit
Thiamine 100 mg/ml vial8.61USD ml
Infuvite pediatric vial2.58USD ml
Vitamin B-1 100 mg/ml1.64USD ml
Thiamiject 100 mg/ml1.24USD ml
Thiamine Hcl 100 mg/ml1.24USD ml
Thiamine hcl powder0.73USD g
Thiamine 100 mg tablet0.21USD tablet
Thiamine 500 mg tablet0.18USD tablet
Vitamin b-1 250 mg tablet0.06USD tablet
Vitamin b-1 100 mg tablet0.05USD tablet
Thiamine 250 mg tablet0.03USD tablet
CVS Pharmacy vitamin b-1 100 mg tablet0.02USD tablet
Vitamin b-1 50 mg tablet0.02USD tablet
Thiamine hcl 50 mg tablet0.01USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point248 dec °CPhysProp
water solubility5E+005 mg/LMERCK INDEX (1996); approx.
Predicted Properties
PropertyValueSource
Water Solubility0.0153 mg/mLALOGPS
logP-2.1ALOGPS
logP-3.1ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)15.5ChemAxon
pKa (Strongest Basic)5.54ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area75.91 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity73.4 m3·mol-1ChemAxon
Polarizability28.14 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-231z000000-48864f31ba475645654bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-za00000000-2ec0f3e9e364cffde16eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-z100000000-0184506492d9f5b68b97View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-01z0000000-872150be83cbd75d8ecfView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-0ze0000000-ecf71c75bdea859139d5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-0z00000000-4d9113fdc633fb1ccbb5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-1z00000000-4a8016299623af0c3027View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negativesplash10-5z00000000-773912c9f325c419c77dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-0dz0000000-95f3ca57c95542bdc7e7View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-0z00000000-e079d1fc1e06396dc524View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-2z00000000-ebb16d4f204f291b9a3aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-gz00000000-ad4d4779d76b9edb7ec5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-zo00000000-b631eed5be831527fc17View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-0z10000000-50f2f613f576814eb627View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-2z00000000-2f184bbfec6bc0ef00c6View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-z200000000-35bc744495a2570a565fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-4z10000000-d8a7ac327273c32b4524View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0z70000000-ca80ef6513c61be5b5e9View in MoNA
1D NMR13C NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,1H] 2D NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Nobuyuki Kitamori, Masaya Maeno, Seiji Izuhara, “Granules of thiamine salt and the production thereof.” U.S. Patent US4702919, issued July, 1974.

US4702919
General References
  1. Slater PV: Multi-level preparation for nursing impact on nursing practice. Aust Nurses J. 1978 Jun;7(11):40-3. [PubMed:249270 ]
  2. Kopriva V, Bilkovic R, Licko T: [Tumours of the small intestine (author's transl)]. Cesk Gastroenterol Vyz. 1977 Dec;31(8):549-53. [PubMed:603941 ]
  3. Beissel J: [The role of right catheterization in valvular prosthesis surveillance (author's transl)]. Ann Cardiol Angeiol (Paris). 1977 Dec;26(6):587-9. [PubMed:606152 ]
  4. Lonsdale D, Shamberger RJ, Audhya T: Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study. Neuro Endocrinol Lett. 2002 Aug;23(4):303-8. [PubMed:12195231 ]
  5. Lonsdale D: A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives. Evid Based Complement Alternat Med. 2006 Mar;3(1):49-59. [PubMed:16550223 ]
External Links
ATC CodesA11DA01
AHFS Codes
  • 88:08.00
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.2 KB)
Interactions
Drug InteractionsNo interactions found.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
ligand
General Function:
Thiamine diphosphokinase activity
Specific Function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.
Gene Name:
TPK1
Uniprot ID:
Q9H3S4
Molecular Weight:
27265.05 Da
References
  1. Pylypchuk SIu, Parkhomenko IuM, Protasova ZS, Vovk AI, Donchenko HV: [Interaction of rat brain thiamine kinase with thiamine and its derivatives]. Ukr Biokhim Zh (1999). 2001 Mar-Apr;73(2):51-6. [PubMed:11642045 ]
  2. Melnick J, Lis E, Park JH, Kinsland C, Mori H, Baba T, Perkins J, Schyns G, Vassieva O, Osterman A, Begley TP: Identification of the two missing bacterial genes involved in thiamine salvage: thiamine pyrophosphokinase and thiamine kinase. J Bacteriol. 2004 Jun;186(11):3660-2. [PubMed:15150256 ]
  3. Bellyei S, Szigeti A, Boronkai A, Szabo Z, Bene J, Janaky T, Barna L, Sipos K, Minik O, Kravjak A, Ohmacht R, Melegh B, Zavodszky P, Than GN, Sumegi B, Bohn H, Than NG: Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK). Placenta. 2005 Jan;26(1):34-46. [PubMed:15664409 ]
  4. de Jong L, Meng Y, Dent J, Hekimi S: Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans. Genetics. 2004 Oct;168(2):845-54. [PubMed:15514058 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Thiamine uptake transmembrane transporter activity
Specific Function:
High-affinity transporter for the intake of thiamine.
Gene Name:
SLC19A2
Uniprot ID:
O60779
Molecular Weight:
55399.49 Da
References
  1. Liberman MC, Tartaglini E, Fleming JC, Neufeld EJ: Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype. J Assoc Res Otolaryngol. 2006 Sep;7(3):211-7. Epub 2006 Apr 27. [PubMed:16642288 ]
  2. Diaz GA, Banikazemi M, Oishi K, Desnick RJ, Gelb BD: Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome. Nat Genet. 1999 Jul;22(3):309-12. [PubMed:10391223 ]
  3. Fleming JC, Tartaglini E, Steinkamp MP, Schorderet DF, Cohen N, Neufeld EJ: The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter. Nat Genet. 1999 Jul;22(3):305-8. [PubMed:10391222 ]
  4. Labay V, Raz T, Baron D, Mandel H, Williams H, Barrett T, Szargel R, McDonald L, Shalata A, Nosaka K, Gregory S, Cohen N: Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness. Nat Genet. 1999 Jul;22(3):300-4. [PubMed:10391221 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP4B1
Uniprot ID:
P13584
Molecular Weight:
58990.64 Da
References
  1. Liu S, Stromberg A, Tai HH, Moscow JA: Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaglandin metabolism in breast cancer cells. Mol Cancer Res. 2004 Aug;2(8):477-87. [PubMed:15328374 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. [PubMed:12089365 ]
  2. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. [PubMed:12606755 ]
  2. Sinclair CJ, Chi KD, Subramanian V, Ward KL, Green RM: Functional expression of a high affinity mammalian hepatic choline/organic cation transporter. J Lipid Res. 2000 Nov;41(11):1841-8. [PubMed:11060354 ]
  3. Green RM, Lo K, Sterritt C, Beier DR: Cloning and functional expression of a mouse liver organic cation transporter. Hepatology. 1999 May;29(5):1556-62. [PubMed:10216142 ]
  4. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular Weight:
62751.08 Da
References
  1. Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. [PubMed:11160873 ]
  2. Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. [PubMed:10454528 ]
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Drug created on June 13, 2005 07:24 / Updated on December 03, 2015 09:51