Showing BioInteractions for Pyruvic acid (DB00119)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Pyruvic acid is a 4-aminobutyrate aminotransferase, mitochondrial inhibitor | ||
| 1 | 4-aminobutyrate aminotransferase, mitochondrial inhibitors | Alanine, Phenelzine, Pyridoxal phosphate, Vigabatrin |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Pyruvic acid is a Monocarboxylate transporter 2 substrate | ||
| 1 | Monocarboxylate transporter 2 inhibitors | Acetoacetic acid, alpha-D-quinovopyranose, alpha-Ketoisovalerate, D-Lactic acid, gamma-Hydroxybutyric acid, Lactic acid, Niflumic acid, Probenecid, Quercetin |
| 2 | Monocarboxylate transporter 2 substrates | Lactic acid |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Pyruvic acid is a Monocarboxylate transporter 2 inhibitor | ||
| 1 | Monocarboxylate transporter 2 inhibitors | Acetoacetic acid, alpha-D-quinovopyranose, alpha-Ketoisovalerate, D-Lactic acid, gamma-Hydroxybutyric acid, Lactic acid, Niflumic acid, Probenecid, Quercetin |
| 2 | Monocarboxylate transporter 2 substrates | Lactic acid |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Pyruvic acid is a Monocarboxylate transporter 1 substrate | ||
| 1 | Monocarboxylate transporter 1 inhibitors | Acetoacetic acid, alpha-D-quinovopyranose, alpha-Ketoisovalerate, D-Lactic acid, gamma-Hydroxybutyric acid, Lactic acid, Niflumic acid, Probenecid, Quercetin |
| 2 | Monocarboxylate transporter 1 substrates | Acetic acid, Acetoacetic acid, Aminohippuric acid, Arbaclofen Placarbil, D-Lactic acid, Foscarnet, Glutamic acid, Lactic acid, Methotrexate, Nateglinide, Niacin, Pravastatin, Salicylic acid, Taurocholic acid, Valproic acid |
| 3 | Monocarboxylate transporter 1 antagonists | Mersalyl |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Pyruvic acid is a Monocarboxylate transporter 1 inhibitor | ||
| 1 | Monocarboxylate transporter 1 inhibitors | Acetoacetic acid, alpha-D-quinovopyranose, alpha-Ketoisovalerate, D-Lactic acid, gamma-Hydroxybutyric acid, Lactic acid, Niflumic acid, Probenecid, Quercetin |
| 2 | Monocarboxylate transporter 1 substrates | Acetic acid, Acetoacetic acid, Aminohippuric acid, Arbaclofen Placarbil, D-Lactic acid, Foscarnet, Glutamic acid, Lactic acid, Methotrexate, Nateglinide, Niacin, Pravastatin, Salicylic acid, Taurocholic acid, Valproic acid |
| 3 | Monocarboxylate transporter 1 antagonists | Mersalyl |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Pyruvic acid is a Monocarboxylate transporter 10 substrate | ||
| 1 | Monocarboxylate transporter 10 inhibitors | Alanine, Arginine, Asparagine, Aspartic acid, Cysteine, Cystine, D-Alanine, D-Leucine, D-Phenylalanine, D-Serine, D-Tryptophan, D-Tyrosine, Droxidopa, Glutamic acid, Glycine, Histidine, Isoleucine, L-Glutamine, Lactic acid, Leucine, Levodopa, Liothyronine, Liotrix, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tryptophan, Tyrosine, Valine |
| 2 | Monocarboxylate transporter 10 substrates | 2-aminoisobutyric acid, beta-Alanine, D-Phenylalanine, Glutamic acid, Glycine, Histidine, Lactic acid, Lysine |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Pyruvic acid is a Monocarboxylate transporter 10 inhibitor | ||
| 1 | Monocarboxylate transporter 10 inhibitors | Alanine, Arginine, Asparagine, Aspartic acid, Cysteine, Cystine, D-Alanine, D-Leucine, D-Phenylalanine, D-Serine, D-Tryptophan, D-Tyrosine, Droxidopa, Glutamic acid, Glycine, Histidine, Isoleucine, L-Glutamine, Lactic acid, Leucine, Levodopa, Liothyronine, Liotrix, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tryptophan, Tyrosine, Valine |
| 2 | Monocarboxylate transporter 10 substrates | 2-aminoisobutyric acid, beta-Alanine, D-Phenylalanine, Glutamic acid, Glycine, Histidine, Lactic acid, Lysine |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Pyruvic acid is a Solute carrier organic anion transporter family member 2A1 inhibitor | ||
| 1 | Solute carrier organic anion transporter family member 2A1 inducers | Phenobarbital |
| 2 | Solute carrier organic anion transporter family member 2A1 inhibitors | beta-D-fructofuranose 1,6-bisphosphate, D-glyceraldehyde 3-phosphate, Furosemide, Glucose-6-Phosphate, Lactic acid, Phosphoenolpyruvate, Rifamycin |
| 3 | Solute carrier organic anion transporter family member 2A1 substrates | Alprostadil, Arachidonic Acid, Dinoprostone, Iloprost, Latanoprost |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Pyruvic acid is a Monocarboxylate transporter 4 substrate | ||
| 1 | Monocarboxylate transporter 4 substrates | Acetoacetic acid, alpha-Ketoisovalerate, D-Lactic acid, Formic acid, gamma-Hydroxybutyric acid, Glyoxylic acid, Lactic acid, Oxamic Acid, Phenylpyruvic acid |